CN103114035A - Device for fully-enclosed extraction, transfer and storage of nucleic acids - Google Patents
Device for fully-enclosed extraction, transfer and storage of nucleic acids Download PDFInfo
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- CN103114035A CN103114035A CN201310080221XA CN201310080221A CN103114035A CN 103114035 A CN103114035 A CN 103114035A CN 201310080221X A CN201310080221X A CN 201310080221XA CN 201310080221 A CN201310080221 A CN 201310080221A CN 103114035 A CN103114035 A CN 103114035A
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Abstract
The invention discloses a device for fully-enclosed extraction, transfer and storage of nucleic acids. The device comprises a sucker and a reaction tube, wherein the sucker comprises a lance pointed end, an O-shaped sealing ring, a spring, a sleeve and a sucker insulated plug, wherein the lance pointed end comprises a lance pointed pipe and a lance pointed needle, wherein an annular groove is formed in the upper part of the inner wall of the sleeve, an annular baffle plate is arranged on the lower part of the inner wall of the sleeve, the lance pointed end is arranged in a cavity of the sleeve, the O-shaped sealing ring is embedded between the lance pointed pipe of the lance pointed head and the sleeve, the spring is sheathed on the outer side of the lance pointed needle, the sucker insulated plug is fixedly connected at the bottom of the cavity of the sleeve, the reaction tube comprises a reagent insulated plug and a reagent storage box and is in a sealing state, and the reagent insulated plug of the reaction tube is in contact with the sucker insulated plug of the sucker. The device can solve the problem that high-concentration aerosol is easy to escape in a process of absorbing nucleic acid amplification afterproducts, thus resulting in the cross contamination.
Description
Technical field
The present invention relates to the medical devices of molecular diagnosis, specifically, relate to the device of a kind of totally-enclosed extraction, transfer and storage nucleic acid.
Background technology
Nucleic acid amplification is the conventional means of molecular diagnosis, the effect by enzyme and primer in reaction tubes of the nucleic acid molecule of sample to be tested can be index and doubly increase, amplify thus thing to be detected and be used for follow-up signal-obtaining experiment, yet the nucleic acid molecule that the drawback of nucleic acid amplification is high density easily exists with aerocolloidal form, make the aerosol loss can cause the crossed contamination of sample room in air in case open the reaction tubes lid, produce false-positive result.At present all molecular diagnosis products that relate to nucleic acid amplification technologies all adopt 2 kinds of modes to prevent this crossed contamination, (1) adopt covered signal interpretation mode, as utilize the mode of real-time quantitative fluorescence PCR, (2) to adopt the mode of totally-enclosed cartridge type will move liquid, nucleic acid amplification and signal interpretation and carry out in a reaction cartridge; Yet and shortcoming also clearly (1) be limited by can not testing signal of uncapping, detection method is single, (2) totally-enclosed cartridge consumptive material has increased cost greatly, is unfavorable for promoting.Therefore both how to acquire the detection of can (reaction tubes) uncapping, the molecular diagnosis new approaches of not crossed contamination seem particularly urgent again.
Summary of the invention
Technical problem:Technical problem to be solved by this invention is: the device of a kind of totally-enclosed extraction, transfer and storage nucleic acid is provided, uncaps with solution and draw in the process of nucleic acid amplification after product, the high density aerosol is easily overflowed, and causes the problem of crossed contamination.
Technical scheme:For solving the problems of the technologies described above, the technical solution used in the present invention is as follows:
The device of a kind of totally-enclosed extraction, transfer and storage nucleic acid, this device comprises suction nozzle and reaction tubes, described suction nozzle comprises rifle tip, O RunddichtringO, spring, sleeve and suction nozzle batching pig, the rifle tip comprises rifle point pipe and is fixedly connected on the rifle prong of rifle point pipe bottom surface, the bottom of rifle prong is most advanced and sophisticated, be provided with the cavity that communicates in rifle point pipe and rifle prong, the top of sleeve lining is provided with annular recesses, the bottom of sleeve lining is provided with ring baffle, the internal diameter of ring baffle is less than the external diameter of rifle point pipe, and the internal diameter of ring baffle is greater than the external diameter of rifle prong; The rifle tip is arranged in the inner chamber of sleeve, and the O RunddichtringO is embedded between the rifle point pipe and sleeve of rifle tip, and the O RunddichtringO is arranged in annular recesses; Spring housing is contained in the rifle prong outside, and the bottom surface of the top of spring and rifle point pipe offsets, and bottom and the ring baffle of spring offset, and the suction nozzle batching pig is fixedly connected on the bottom of barrel bore, and the suction nozzle batching pig is positioned at below ring baffle;
Described reaction tubes comprises that reagent batching pig and top are the reagent storage box of opening, the reagent batching pig is fixedly connected on the opening of reagent storage box, reaction tubes is sealed state, and reaction tubes is positioned at below suction nozzle, and the suction nozzle batching pig of the reagent batching pig of reaction tubes and suction nozzle touches mutually.
Further, described rifle point pipe, rifle prong, O RunddichtringO, sleeve, the coaxial setting of ring baffle.
Further, described rifle point pipe is made by PP or PE material, and the rifle prong is made by stainless steel.
Further, the outside surface of described O RunddichtringO scribbles the medical ventolin coating.
Beneficial effect:Compared with prior art, technical scheme of the present invention has following beneficial effect:
(1) full-enclosed structure design effectively prevents the pollution of nucleic acid in transfer process.Compare with traditional suction pipette head, device of the present invention is to improve on the basis of traditional suction pipette head, and has increased a rifle point enclosed appts, and the sealing device comprises O RunddichtringO, spring, sleeve and suction nozzle batching pig.The O RunddichtringO is embedded between the rifle point pipe and sleeve of rifle tip, and the O RunddichtringO is arranged in the annular recesses of sleeve.The O RunddichtringO has been isolated inner chamber and the external environment of sleeve.The suction nozzle batching pig is fixedly connected on the bottom of barrel bore.The suction nozzle batching pig also plays sealing function, has isolated inner chamber and the external environment of sleeve.Like this, by suction nozzle batching pig and O RunddichtringO are set, seal sleeve, thereby made the rifle prong that is arranged in sleeve also be isolated from the outside.In use, the suction nozzle batching pig is positioned on the reagent batching pig, and both contact.Like this, after the rifle prong passes the suction nozzle batching pig, directly pierce through the reagent batching pig, enter in the reagent storage box, can not contact with the external world.This suction nozzle and reaction tubes have been combined to form an enclosed environment, have prevented the amplified production aerosol effusion in the reaction tubes, have also eliminated crossed contamination, have improved the accuracy of Bioexperiment and medical diagnosis on disease.Like this, device of the present invention can guarantee suction pipette head in imbibition, moving the process of liquid and liquid feeding, and reagent can not contact with extraneous air and produce crossed contamination.
(2) suitability is strong, and suction nozzle can coordinate current pipettor manually or automatically commonly used, goes forward side by side to exercise and uses.
(3) simple in structure, low cost of manufacture.The inventive system comprises suction nozzle and reaction tubes, suction nozzle comprises rifle tip, O RunddichtringO, spring, sleeve and suction nozzle batching pig, and reaction tubes comprises reagent batching pig and reagent storage box.Whole apparatus structure is simple.The material of making simultaneously this device is all the medical material of commonly using, low cost of manufacture, and difficulty of processing is low, is easy to assembling.
Description of drawings
Fig. 1 is the structural representation that rifle tip of the present invention is arranged in sleeve.
Structural representation when Fig. 2 is rifle tip insertion reaction pipe of the present invention.
Fig. 3 is the structural representation of suction nozzle of the present invention.
Fig. 4 is the structural representation of reaction tubes of the present invention.
Have in figure: rifle tip 1, rifle point pipe 101, rifle prong 102, O RunddichtringO 2, spring 3, sleeve 4, suction nozzle batching pig 5, reagent batching pig 6, reagent storage box 7, ring baffle 8.
Embodiment
Below in conjunction with accompanying drawing, technical scheme of the present invention is described in detail.
As shown in Figures 1 to 4, the device of a kind of totally-enclosed extraction of the present invention, transfer and storage nucleic acid comprises suction nozzle and reaction tubes.Suction nozzle comprises rifle tip 1, O RunddichtringO 2, spring 3, sleeve 4 and suction nozzle batching pig 5.Rifle tip 1 comprises rifle point pipe 101 and is fixedly connected on the rifle prong 102 of rifle point pipe 101 bottom surfaces.The rifle tip adopts injection molding to form.As preferably, sleeve 4 by the English full name of PP(is: Polypropylene, Chinese translation: polypropylene, be called for short PP in literary composition) or the English full name of PE(be: Polyethylene, Chinese translation: polyethylene, being called for short PE in literary composition) material makes, and rifle point pipe 101 is made by PP or PE material, and rifle prong 102 is made by stainless steel.The bottom of rifle prong 102 is most advanced and sophisticated.Like this, rifle prong 102 is easily poked suction nozzle batching pig 5 and reagent batching pig 6.Be provided with the cavity that communicates in rifle point pipe 101 and rifle prong 102.The top of sleeve 4 inwalls is provided with annular recesses, and the bottom of sleeve 4 inwalls is provided with ring baffle 8.The internal diameter of ring baffle 8 is less than the external diameter of rifle point pipe 101, and the internal diameter of ring baffle 8 is greater than the external diameter of rifle prong 102.Like this, rifle prong 102 can pass the inner chamber of ring baffle 8, and rifle point pipe 101 can not pass the inner chamber of ring baffle 8.Rifle tip 1 is arranged in the inner chamber of sleeve 4.O RunddichtringO 2 is embedded between the rifle point pipe 101 and sleeve 4 of rifle tip, and O RunddichtringO 2 is arranged in annular recesses.O RunddichtringO 2 plays sealing function, has isolated inner chamber and the external environment of sleeve 4.Spring 3 is sleeved on rifle prong 102 outsides, and the bottom surface of the top of spring 3 and rifle point pipe 101 offsets, and the bottom of spring 3 and ring baffle 8 offset.Suction nozzle batching pig 5 is fixedly connected on the bottom of sleeve 4 inner chambers, and suction nozzle batching pig 5 is positioned at ring baffle 8 belows.Suction nozzle batching pig 5 also plays sealing function, has isolated inner chamber and the external environment of sleeve 4.Reaction tubes comprises that reagent batching pig 6 and top are the reagent storage box 7 of opening.Reagent batching pig 6 is fixedly connected on the opening of reagent storage box 7, and reagent batching pig 6 has sealed reagent storage box 7, and making reaction tubes is sealed state.Reagent batching pig 6 shapes are preferably patty.Reagent batching pig 6 is placed on the upper opening of reagent storage box 7, prevents that in the nucleic acid amplification reaction pipe, aerosol spills in outside atmosphere.Reaction tubes is positioned at below suction nozzle, and the suction nozzle batching pig 5 of the reagent batching pig 6 of reaction tubes and suction nozzle touches mutually.
Further, described rifle point pipe 101, rifle prong 102, O RunddichtringO 2, sleeve 4, the coaxial setting of ring baffle 8.Being conducive to like this rifle tip 1 draws reagent and add reagent in reagent storage box 7 from reagent storage box 7.
Further, the outside surface of described O RunddichtringO 2 scribbles the medical ventolin coating.This coating can play effect lubricated and sealing.
Further, as preferred version, described suction nozzle batching pig 5 is made by medical grade rubber or medical natural rubber.Described reagent batching pig 6 is made by medical grade rubber or medical natural rubber.Medical grade rubber or medical natural rubber material have good springiness, the characteristics that easily pierce through.Reagent storage box 7 is made by PP or PE material.Reagent storage box 7 is preferably single hose, and perhaps 96 hole reactions are board-like.
The device installation process of the totally-enclosed extraction of said structure, transfer and storage nucleic acid is: after smearing the medical ventolin coating on O RunddichtringO 2 surfaces, O RunddichtringO 2 is positioned in annular recesses on sleeve 4 inwalls, spring 3 is packed in sleeve 4 by sleeve 4 tops, again rifle tip 1 is positioned in sleeve 4, make spring 3 be sleeved on rifle prong 102 outsides, and make spring 3 between the bottom surface and ring baffle 8 of rifle point pipe 101, the lower end of sleeve 4 seals with suction nozzle batching pig 5, thereby completes the assembling of suction nozzle.Seal with the opening of reagent batching pig 6 with reagent storage box 7, complete the assembling of reaction tubes.
The working process of the device of the totally-enclosed extraction of said structure, transfer and storage nucleic acid is: when imbibition or liquid feeding, suction nozzle is installed on pipettor, and the lower end of suction nozzle is vertical, and the upper port of aiming at reaction tubes; Pipettor is when pressing down, make rifle prong 102 penetrate suction nozzle batching pig 5 and reagent batching pig 6 downwards, enter in closed nucleic acid amplification reaction pipe, can carry out imbibition or liquid feeding to the reagent in closed nucleic acid amplification reaction pipe, then upwards promote rifle tip 1, the pressure that is subject on spring 3 discharges gradually, rifle prong 102 is not being got back to sleeve 4 when interior fully, due to the compressing that is subject to spring 3, suction nozzle batching pig 5 and reagent batching pig 6 be close contact always, until rifle prong 102 returns in sleeve 4 fully.When rifle prong 102 returns in sleeve 4 fully, spring 3 does not have pressure, and sleeve 4 will move upward with rifle tip 1, and sleeve 4 separates with the enclosed nucleic acid amplification reaction pipe of bottom.Because reagent batching pig 6 and suction nozzle batching pig 5 all adopt medical grade rubber or medical natural rubber to make, so after rifle prong 102 is extracted, the reagent batching pig 6 that rifle prong 102 passes and the hole of suction nozzle batching pig 5 are with auto-closing, and sealed reagent storage box 7 and sleeve 4 avoid reagent to leak.Adopt this device in whole imbibition, moving liquid and liquid feeding process, can avoid reagent to contact with outside air, prevented crossed contamination.
The below lifts a specific embodiment, is described below:
To pressing down rifle tip 1, rifle prong 102 is deep in reagent storage box 7 after penetrating suction nozzle batching pig 5 and reagent batching pig 6, realizes the action of imbibition and liquid feeding.After action is completed, upwards promote rifle tip 1, get back to sleeve 4 fully when interior until rifle prong 102, when continuing to promote rifle tip 1, when spring 3 is not under pressure, sleeve 4 will move upward with rifle tip 1, separate with the enclosed nucleic acid amplification reaction pipe of bottom.In whole imbibition, moving liquid and liquid feeding process, the reagent in rifle prong 102 and reaction tubes can not be exposed in outside atmosphere.
Claims (9)
1. totally-enclosed extraction, shift and store the device of nucleic acid, it is characterized in that, this device comprises suction nozzle and reaction tubes, described suction nozzle comprises rifle tip (1), O RunddichtringO (2), spring (3), sleeve (4) and suction nozzle batching pig (5), rifle tip (1) comprises rifle point pipe (101) and is fixedly connected on the rifle prong (102) of rifle point pipe (101) bottom surface, the bottom of rifle prong (102) is most advanced and sophisticated, be provided with the cavity that communicates in rifle point pipe (101) and rifle prong (102), the top of sleeve (4) inwall is provided with annular recesses, the bottom of sleeve (4) inwall is provided with ring baffle (8), the internal diameter of ring baffle (8) is less than the external diameter of rifle point pipe (101), the internal diameter of ring baffle (8) is greater than the external diameter of rifle prong (102), rifle tip (1) is arranged in the inner chamber of sleeve (4), and O RunddichtringO (2) is embedded between the rifle point pipe (101) and sleeve (4) of rifle tip, and O RunddichtringO (2) is arranged in annular recesses, spring (3) is sleeved on outside rifle prong (102), and the bottom surface of the top of spring (3) and rifle point pipe (101) offsets, the bottom of spring (3) and ring baffle (8) offset, suction nozzle batching pig (5) is fixedly connected on the bottom of sleeve (4) inner chamber, and suction nozzle batching pig (5) is positioned at below ring baffle (8),
Described reaction tubes comprises that reagent batching pig (6) and top are the reagent storage box (7) of opening, reagent batching pig (6) is fixedly connected on the opening of reagent storage box (7), reaction tubes is sealed state, reaction tubes is positioned at below suction nozzle, and the suction nozzle batching pig (5) of the reagent batching pig (6) of reaction tubes and suction nozzle touches mutually.
2. according to the device of totally-enclosed extraction claimed in claim 1, transfer and storage nucleic acid, it is characterized in that described rifle point pipe (101), rifle prong (102), O RunddichtringO (2), sleeve (4), the coaxial setting of ring baffle (8).
3. the device of totally-enclosed extraction according to claim 1, transfer and storage nucleic acid, is characterized in that, described rifle point pipe (101) is made by PP or PE material, and rifle prong (102) is made by stainless steel.
4. the device of totally-enclosed extraction according to claim 1, transfer and storage nucleic acid, is characterized in that, the outside surface of described O RunddichtringO (2) scribbles the medical ventolin coating.
5. the device of totally-enclosed extraction according to claim 1, transfer and storage nucleic acid, is characterized in that, described sleeve (4) is made by PP or PE material.
6. the device of totally-enclosed extraction according to claim 1, transfer and storage nucleic acid, is characterized in that, described suction nozzle batching pig (5) is made by medical grade rubber or medical natural rubber.
7. the device of totally-enclosed extraction according to claim 1, transfer and storage nucleic acid, is characterized in that, described reagent batching pig (6) is made by medical grade rubber or medical natural rubber.
8. the device of totally-enclosed extraction according to claim 1, transfer and storage nucleic acid, is characterized in that, described reagent storage box (7) is made by PP or PE material.
9. the device of totally-enclosed extraction according to claim 1, transfer and storage nucleic acid, is characterized in that, described reagent storage box (7) is single hose, and perhaps 96 hole reactions are board-like.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310080221.XA CN103114035B (en) | 2013-03-14 | 2013-03-14 | Device for fully-enclosed extraction, transfer and storage of nucleic acids |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310080221.XA CN103114035B (en) | 2013-03-14 | 2013-03-14 | Device for fully-enclosed extraction, transfer and storage of nucleic acids |
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| Publication Number | Publication Date |
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| CN103114035A true CN103114035A (en) | 2013-05-22 |
| CN103114035B CN103114035B (en) | 2014-04-02 |
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| CN201310080221.XA Active CN103114035B (en) | 2013-03-14 | 2013-03-14 | Device for fully-enclosed extraction, transfer and storage of nucleic acids |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105039135A (en) * | 2015-06-29 | 2015-11-11 | 诸暨脉达生物科技有限公司 | Semiautomatic paraffin pre-sealing and sample-adding device and using method thereof |
| CN105940105A (en) * | 2014-06-17 | 2016-09-14 | 深圳迈瑞生物医疗电子股份有限公司 | Nucleic acid extraction device and method |
| CN106318865A (en) * | 2016-10-25 | 2017-01-11 | 西安交通大学 | Portable device for nucleic acid extraction and gene amplification |
| CN106434639A (en) * | 2016-12-01 | 2017-02-22 | 山东森芃生物科技有限公司 | DNA extracting method needing no tube transferring |
| CN108531377A (en) * | 2018-06-26 | 2018-09-14 | 广东省第二人民医院（广东省卫生应急医院） | It is a kind of can pre-filled reagent diaphragm type nucleic acid amplification airtight reactor tube |
| CN109856413A (en) * | 2019-03-29 | 2019-06-07 | 广东合鑫生物科技有限公司 | A kind of reagent pipetting volume device and reagent pipetting volume system |
| CN110102242A (en) * | 2019-06-12 | 2019-08-09 | 成都恩普生医疗科技有限公司 | A kind of reaction cup and mixing method of collection encapsulation and mixing one |
| CN114058472A (en) * | 2020-07-30 | 2022-02-18 | 苏州中加康美科技有限公司 | Nucleic acid reagent reaction unit |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105940105A (en) * | 2014-06-17 | 2016-09-14 | 深圳迈瑞生物医疗电子股份有限公司 | Nucleic acid extraction device and method |
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| CN109856413A (en) * | 2019-03-29 | 2019-06-07 | 广东合鑫生物科技有限公司 | A kind of reagent pipetting volume device and reagent pipetting volume system |
| CN110102242A (en) * | 2019-06-12 | 2019-08-09 | 成都恩普生医疗科技有限公司 | A kind of reaction cup and mixing method of collection encapsulation and mixing one |
| CN110102242B (en) * | 2019-06-12 | 2023-09-05 | 成都恩普生医疗科技有限公司 | Reaction cup integrating packaging and mixing method |
| CN114058472A (en) * | 2020-07-30 | 2022-02-18 | 苏州中加康美科技有限公司 | Nucleic acid reagent reaction unit |
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| CN103114035B (en) | 2014-04-02 |
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