CN103113333A - 一种维生素c乙基醚的合成方法 - Google Patents
一种维生素c乙基醚的合成方法 Download PDFInfo
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- CN103113333A CN103113333A CN2012105573195A CN201210557319A CN103113333A CN 103113333 A CN103113333 A CN 103113333A CN 2012105573195 A CN2012105573195 A CN 2012105573195A CN 201210557319 A CN201210557319 A CN 201210557319A CN 103113333 A CN103113333 A CN 103113333A
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- FGHJBMJPECRPCS-BYPYZUCNSA-N CCOC(C([C@H](CO)O)=[O]C1=O)=C1O Chemical compound CCOC(C([C@H](CO)O)=[O]C1=O)=C1O FGHJBMJPECRPCS-BYPYZUCNSA-N 0.000 description 1
- ZGSCRDSBTNQPMS-UJURSFKZSA-N CCOC([C@@H]([C@H](CO)O)OC1=O)=C1O Chemical compound CCOC([C@@H]([C@H](CO)O)OC1=O)=C1O ZGSCRDSBTNQPMS-UJURSFKZSA-N 0.000 description 1
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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Priority Applications (1)
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CN201210557319.5A CN103113333B (zh) | 2012-12-20 | 2012-12-20 | 一种维生素c乙基醚的合成方法 |
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CN201210557319.5A CN103113333B (zh) | 2012-12-20 | 2012-12-20 | 一种维生素c乙基醚的合成方法 |
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CN103113333A true CN103113333A (zh) | 2013-05-22 |
CN103113333B CN103113333B (zh) | 2015-07-08 |
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105367524A (zh) * | 2015-06-19 | 2016-03-02 | 上海珈叶实业有限公司 | 3-o-烷基抗坏血酸的制备方法 |
CN106565646A (zh) * | 2016-11-12 | 2017-04-19 | 北京华信龙悦科技有限公司 | 一种美白剂原料的合成方法 |
CN108997277A (zh) * | 2018-06-29 | 2018-12-14 | 浙江拓普药业股份有限公司 | 一种Vc乙基醚生产方法 |
CN110642816A (zh) * | 2019-09-25 | 2020-01-03 | 旖肽(上海)生物科技有限公司 | 结晶型3-o-乙基维生素c及其制备方法和应用 |
CN111638298A (zh) * | 2020-06-30 | 2020-09-08 | 山东省药学科学院 | 一种维生素c乙基醚中有关物质的高效液相色谱法测定方法 |
CN112142697A (zh) * | 2020-10-28 | 2020-12-29 | 浙江拓普药业股份有限公司 | 一种Vc乙基醚的生产工艺 |
CN112778246A (zh) * | 2021-01-12 | 2021-05-11 | 上海珈凯生物科技有限公司 | 一种维生素c乙基醚合成方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101302207A (zh) * | 2007-04-18 | 2008-11-12 | 日本海博克斯股份有限公司 | 3-o-烷基-5,6-o-(1-甲基乙叉基)-l-抗坏血酸的制造方法以及5,6-o-(1-甲基乙叉基)-l-抗坏血酸的制造方法 |
KR20090066910A (ko) * | 2007-12-20 | 2009-06-24 | 주식회사 메디켐코리아 | L-3-o-치환-아스코르브산의 개선된 제조방법 |
JP2010064966A (ja) * | 2008-09-09 | 2010-03-25 | Kyoei Kagaku Kogyo Kk | L−アスコルビン酸誘導体の製造方法 |
TW201040152A (en) * | 2009-05-07 | 2010-11-16 | Cosmol Co Ltd | Method for preparing ascorbic acid derivatives |
WO2012007748A1 (en) * | 2010-07-13 | 2012-01-19 | Astrazeneca Ab | New crystalline forms of n-[2-[[(2,3-difluoropheny)methyl)thio]-6-{[(1r,2s)-2,3-dihydroxy-1- methylpropyl]oxy}-4-pyrimidinyl]-1-azetidinesulfonamide |
-
2012
- 2012-12-20 CN CN201210557319.5A patent/CN103113333B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101302207A (zh) * | 2007-04-18 | 2008-11-12 | 日本海博克斯股份有限公司 | 3-o-烷基-5,6-o-(1-甲基乙叉基)-l-抗坏血酸的制造方法以及5,6-o-(1-甲基乙叉基)-l-抗坏血酸的制造方法 |
KR20090066910A (ko) * | 2007-12-20 | 2009-06-24 | 주식회사 메디켐코리아 | L-3-o-치환-아스코르브산의 개선된 제조방법 |
JP2010064966A (ja) * | 2008-09-09 | 2010-03-25 | Kyoei Kagaku Kogyo Kk | L−アスコルビン酸誘導体の製造方法 |
TW201040152A (en) * | 2009-05-07 | 2010-11-16 | Cosmol Co Ltd | Method for preparing ascorbic acid derivatives |
WO2012007748A1 (en) * | 2010-07-13 | 2012-01-19 | Astrazeneca Ab | New crystalline forms of n-[2-[[(2,3-difluoropheny)methyl)thio]-6-{[(1r,2s)-2,3-dihydroxy-1- methylpropyl]oxy}-4-pyrimidinyl]-1-azetidinesulfonamide |
Non-Patent Citations (3)
Title |
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MICHAEL E.JUNG,TERESA J.SHAW: "Total Synthesis of (R)-Glycerol Acetonide and the Antiepileptic and Hypotensive Drug (-)-γ-Amino-β-hydroxybutyric Acid (GABOB): Use of Vitamin C as a Chiral Starting Material", 《J.AM.CHEM.SOC.》 * |
NADIM S.SHAIKH等: "Mild and facile procedure for clay-catalyzed acetonide protection and deprotection of N(Boc)-amino alcohols and protection of 1,2-diols", 《TETRAHEDRON LETTERS》 * |
YASUNORI NIHRO等: "3-O-Alkylascorbic Acids as Free Radical Quenchers. 3. Protective Effect on Coronary Occlusion-Raperfusion Induced Arrhythmias in Anesthetized Rats", 《J.MED.CHEM.》 * |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105367524A (zh) * | 2015-06-19 | 2016-03-02 | 上海珈叶实业有限公司 | 3-o-烷基抗坏血酸的制备方法 |
CN106565646A (zh) * | 2016-11-12 | 2017-04-19 | 北京华信龙悦科技有限公司 | 一种美白剂原料的合成方法 |
CN108997277A (zh) * | 2018-06-29 | 2018-12-14 | 浙江拓普药业股份有限公司 | 一种Vc乙基醚生产方法 |
CN110642816A (zh) * | 2019-09-25 | 2020-01-03 | 旖肽(上海)生物科技有限公司 | 结晶型3-o-乙基维生素c及其制备方法和应用 |
CN111638298A (zh) * | 2020-06-30 | 2020-09-08 | 山东省药学科学院 | 一种维生素c乙基醚中有关物质的高效液相色谱法测定方法 |
CN112142697A (zh) * | 2020-10-28 | 2020-12-29 | 浙江拓普药业股份有限公司 | 一种Vc乙基醚的生产工艺 |
CN112778246A (zh) * | 2021-01-12 | 2021-05-11 | 上海珈凯生物科技有限公司 | 一种维生素c乙基醚合成方法 |
CN112778246B (zh) * | 2021-01-12 | 2022-02-25 | 上海珈凯生物科技有限公司 | 一种维生素c乙基醚合成方法 |
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CN103113333B (zh) | 2015-07-08 |
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Effective date of registration: 20131205 Address after: 322118, 333 Jiangnan Road, Dongyang, Zhejiang, Jinhua, Hengdian Applicant after: ZHEJIANG APELOA KANGYU PHARMACEUTICAL Co.,Ltd. Applicant after: SHANGHAI YUYUAN BIOLOGICAL MEDICINE RESEARCH AND DEVELOPMENT Co.,Ltd. Address before: 322118, 333 Jiangnan Road, Dongyang, Zhejiang, Jinhua, Hengdian Applicant before: ZHEJIANG APELOA KANGYU PHARMACEUTICAL Co.,Ltd. Applicant before: SHANGHAI APELOA PHARMACEUTICAL RES Co.,Ltd. |
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Effective date of registration: 20221010 Address after: 322118 No.333 Jiangnan Road, Hengdian, Dongyang City, Jinhua City, Zhejiang Province Patentee after: ZHEJIANG APELOA KANGYU PHARMACEUTICAL Co.,Ltd. Patentee after: Shanghai Puluochuangzhi Pharmaceutical Technology Co.,Ltd. Patentee after: APELOA PHARMACEUTICAL CO.,LTD. Address before: 322118 No.333 Jiangnan Road, Hengdian, Dongyang City, Jinhua City, Zhejiang Province Patentee before: ZHEJIANG APELOA KANGYU PHARMACEUTICAL Co.,Ltd. Patentee before: SHANGHAI YUYUAN BIOLOGICAL MEDICINE RESEARCH AND DEVELOPMENT Co.,Ltd. |
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