CN103100072B - 治疗直肠炎、盲肠炎和抑制直肠癌的中药组合物 - Google Patents
治疗直肠炎、盲肠炎和抑制直肠癌的中药组合物 Download PDFInfo
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Abstract
本发明的中药组合物,按重量份计为:柴胡6-15份、扁豆6-15份、香附6-15份、枳实10-20份、半夏6-15份、茯苓6-15份、干姜10-15份、黄连10-15份、乌梅15-20份、木通3-6份、甘草2-4份、葛根6-15份,主要是在制备用于治疗直肠炎、盲肠炎和抑制直肠癌的药物中的应用。本发明是基于中医辨证施治的原则,标本兼治,虚实并治,内外通调,缓急兼收,筛选出理气泄热,解毒散结的天然植物药,根据中医理论组方,按照一定的量配比制备而成。本发明提供了一种疗效显著、成本低廉的治疗直肠炎、盲肠炎和抑制直肠癌的中药组合物,无任何毒副作用,患者使用安全、方便。
Description
技术领域
本发明涉及医药领域,特别涉及治疗直肠炎、盲肠炎和抑制直肠癌的中药组合物。
背景技术
随着人们生活水平的提高和生活方式的改变,消化道疾病是临床常见病之一,发病率呈逐年上升趋势,尤其是肠炎。肠炎是细菌、病毒、真菌和寄生虫等引起的胃肠炎、直肠炎和结肠炎。临床上主要表现有恶心、呕吐、腹痛、腹泻、浠水便或粘液脓血便。肠炎按病程长短不同,分为急性和慢性两类。慢性肠炎病程一般在两个月以上,临床常见的有慢性细菌性痢疾、慢性阿米巴痢疾、血吸虫病、非特异性溃疡性结肠炎和限局性肠炎等。全世界每年肠炎发病约30-50亿人次,尤其以发展中国家发病率和病死率为高,特别是儿童。根据世界卫生组织统计,在发展中国家,慢性腹泻是儿童发病率最高的传染病,病死率约20‰,仅在亚非拉地区,每年就要夺去约460万婴幼儿生命。
直肠炎是一种常见的肠炎疾病,多为慢性直肠炎,易反复发作,治愈难,对很多直肠炎患者都造成了不小的困扰。直肠炎是由于饮食不慎,如过度饮酒,过量食用刺激性强的食物等,不当的长期服用减肥药品,***内腐蚀性药物过多,细菌感染等引起的。轻者仅粘膜发炎,重者累及粘膜下层、肌层,甚至直肠周围组织,有时是一部分直肠粘膜受累,有时直肠粘膜全部发炎,还可能累及结肠粘膜也产生炎症。中医认为直肠炎与“湿热内瘟”、“饮食停滞”、“脾胃虚弱”和“虫积湿滞”有关。直肠炎常见于体质虚弱抵抗力低下,心、肺、肝、胃肠道疾病、呼吸道感染等,大便秘结、腹泻、痔,肛管直肠脱垂,肛瘘、息肉病、***直肠狭窄、直肠肿瘤、直肠损伤、异物等,都可使直肠发炎,严重的需立刻去医院进行手术治疗。
直肠炎症虽然在直肠部位,然而其炎症会影响整个肠道,长期的直肠炎刺激,会形成溃疡等病变。直肠是大便必经的最后通道,长期的炎症刺激,不但会产生各种致病菌,还会使大便中的致癌物质被激活,进一步引起直肠细胞的癌变。
盲肠炎不同于一般的肠炎疾病,是急性腹痛最常见的病因之一,每个人一生中平均有7%的机率会发生盲肠炎,以十至三十岁最多,而五岁以下及五十岁以上则相对少见。盲肠炎大多是阑尾在盲肠的出口受阻,继发细菌感染所致;但另有30%病例未见阻塞,其发炎可能因病毒、寄生虫或细菌感染、创伤或开刀后粪便滞留所致。临床表现通常先是心窝处或肚脐周围模糊痛,然后逐渐往右下腹转移,伴有低度发烧、恶心、呕吐、疲倦等症状。若治疗不及时,会并发广泛性腹膜炎,严重者可能引起败血症而死亡,近年来,临床发病率有不断上升的趋势。
现代医学对临床某一症状治疗,往往难以达到预期效果,找不到合适的治疗方法。各种肠炎疾病,尤其是慢性肠炎,因其病因复杂,病程较长,无特效药物,西医治疗效果不佳,毒副作用多。各种西药制剂虽然短期内效果明显,但制剂价格昂贵,需长期服用维持治疗,患者经济压力大。如一些激素类药物以及联用免疫调节剂口服治疗慢性肠炎时,对短期缓解症状效果显著,但长期服用会产生满月脸、痤疮、失眠、机体抗感染能力降低等副作用,且不能防止复发;免疫调节剂由于具有细胞毒性作用,长期应用可引起肝肾毒性,白细胞下降等严重后果,所以用药需谨慎。对慢性疾病求诊于中医辨证施治是可取思路,但目前常用的中药方剂和剂型虽然有一定疗效,也不是很理想。各种中药方剂可能限于具体观察的人群情况不同,长期较大病例数的临床观察不足,致使疗效不甚稳定,难以推广和固定组方。
这些情况表明,现有治疗肠炎疾病,具体为直肠炎和盲肠炎,所用的西药毒副作用大,干扰全身各***的生理功能;一般的临用中药疗程长,效果不明显,不利于患者生理和心理的创伤修复。所以迫切需要研制一种疗效显著、稳定,并且毒副作用小,价廉易用的药物制剂。
发明内容
本发明的目的就是针对上述临床中现有治疗肠炎疾病存在的问题,提供一种便捷有效的中药组合物。从肠道的生理特点和肠炎疾病的病理出发,改善机体内阴阳偏盛偏衰的状况,调和脾胃、肝肾,使气血营和畅通,加之中药均含有微量的矿物元素,进入人体后,供机体选择其有效成分,并参与人体新陈代谢,从整体上调理人体阴阳、脏腑、气血的平衡,使免疫功能提高,祛病固本。又因中草药对人体副作用较小,且能标本兼治,因此选择中药治疗肠道疾病,是行之有效的选择。
本发明选择柴胡、扁豆、香附、枳实、半夏、茯苓、干姜、黄连、乌梅、木通、甘草、葛根12种中药进行组合,依据中药相生相克的原则,将这些药物有效组合,使得各药物功效产生协同作用,从而达到清热燥湿,调和气血的功效,改善机体内阴阳偏盛偏衰的状况,使脾胃、肝肾营和有度。其中,柴胡苦辛微寒,具有透表泄热、疏肝解郁、升举阳气之功;扁豆甘淡温和,可健脾和中、消暑化湿;香附辛微苦甘,可理气解郁、治肝胃不和、气郁不舒;枳实苦寒,可破气、散痞、泻痰、消积、治胸腹胀满;半夏性温、味辛,可燥湿化痰、降逆止呕、消痞散;茯苓味甘、淡平,入心、肺、脾经,具有渗湿利水、健脾和胃、宁心安神的功效;干姜辛热、温中散寒,可回阳通脉、温肺化饮;黄连清热燥湿、泻火解毒;乌梅酸涩、功善收敛,上能敛肺气、下能涩大肠,入胃又能生津、安蛔;木通性味苦、凉,可泻火行水、通利血脉、消散胸中烦热、喉痹咽痛;甘草味甘、平,和中缓急、润肺、解毒、调和诸药;葛根味甘、辛,解肌退热、透疹、生津止渴、升阳止泻。
本发明的药物用量,按重量份计为:柴胡6-15份、扁豆6-15份、香附6-15份、枳实10-20份、半夏6-15份、茯苓6-15份、干姜10-15份、黄连10-15份、乌梅15-20份、木通3-6份、甘草2-4份、葛根6-15份。
优选为:柴胡10份、扁豆10份、香附10份、枳实15份、半夏10份、茯苓6-15份、干姜13份、黄连13份、乌梅18份、木通5份、甘草3份、葛根10份。
本发明的中药组合物,主要是在制备用于治疗直肠炎、盲肠炎和抑制直肠癌的药物中的应用。
本发明的中药组合物的剂型为散剂、片剂、草药汤剂、胶剂或口服液制剂。
所述中药组合物的散剂的制备方法,包括以下步骤:
1)粉碎:将所述组份按配比混合,投入粉碎机粉碎成细粉,至粒度为80-110目;
2)混合:将步骤1)所得细粉投入混合搅拌机充分混合;
3)加热:将步骤2)所得在65-80℃下加热25-40分钟;
4)储存:将步骤3)所得冷却后,袋装或瓶装,置放于阴凉干燥处。
所述中药组合物的草药汤剂的制备方法,包括以下步骤:
1)备料:将所述组份按配比混合后碾碎,每剂中药饮片不长于3cm;
2)浸泡:将步骤1)所得置于煎药容器,用冷水中浸泡20-30分钟,用水量浸过药面1-3cm;
3)煎药:将步骤2)所得先用猛火煎至充分沸腾1-3分钟,然后收至文火,煎30-60分钟;
4)用药:将步骤3)所得用消毒纱布过滤得所需药液,倒入杯内,温热服用。
在草药汤剂的制备过程中,所用的煎药容器为砂锅或搪瓷器皿,不宜使用铁锅或铝锅,以免中药所含的部分活性成分物质与金属器皿发生化学反应,影响药用效果。
煎药所用的水为凉开水、井水或者泉水。由于凉开水一般是由自来水烧沸后冷却而来,而自来水经过了漂白粉处理,含有大量的氯元素,若直接用自来水熬制,氯离子可能与中药成分发生化学反应,对中药的药效造成影响。还可直接取用井水或者泉水熬制,效果更佳。
本发明是基于中医辨证施治的原则,标本兼治,虚实并治,内外通调,缓急兼收,筛选出理气泄热,解毒散结的天然植物药,根据中医理论组方,按照一定的量配比制备而成。提供了一种疗效显著、成本低廉的治疗直肠炎、盲肠炎和抑制直肠癌的中药组合物,无任何毒副作用,患者使用安全、方便。
具体实施方式
多年来,为验证本发明药剂的积极效果,发明人在临床上进行了大量的试验,在适用于发明人居住地所在周边地区的患者后,收到了明显的效果。根据收治患者的情况,总结如下:收治患者共62例,其中,男性患者38例,女性患者24例,男女比例为1.6∶1;年龄14-35岁18例,36-65岁44例。具体的,直肠炎患者22例,盲肠炎患者34例,直肠癌患者6例。
现选择部分临床试验报告如下:
1.诊疗评定标准:
痊愈:临床症状消失,停药半年未见复发。
有效:症状减轻,但未完全好转。
无效:症状无明显改变。
2.诊断标准:中医辨证分型,西医检验诊断效果。
3.治疗方法:将本发明的中药组合物制成散剂、片剂、草药汤剂、胶剂或口服液制剂服用。
4.药用方法:本发明的用药量取决于具体剂型、病人年龄、体重和健康状况等因素,由于所述中药组合物的剂型可为散剂、片剂、草药汤剂、胶剂或口服液制剂。故具体用量需要根据病人的病理特征、具体病因等实际情况,因病施治。
作为药用指导:取柴胡6-15g、扁豆6-15g、香附6-15g、枳实10-20g、半夏6-15g、茯苓6-15g、干姜10-15g、黄连10-15g、乌梅15-20g、木通3-6g、甘草2-4g、葛根6-15g。将上述中药料混合后,按草药汤剂的制备方法熬制后服用,早晚各一次。
优选的,各组分的量为:柴胡10g、扁豆10g、香附10g、枳实15g、半夏10g、茯苓6-15g、干姜13g、黄连13g、乌梅18g、木通5g、甘草3g、葛根10g。
5.临床资料汇总:
以下各选取一个典型病例具体说明:
典型病例1:刘某,女,40岁,腹痛、腹泻、大便不成型、时有便血现象,肠鸣及排便不畅、全身乏力、恶寒、头昏等症,经医院消炎补液后症状缓解。平常时常复发,稍有饮食不当,如吃些辛辣食物就会大便不畅,常伴有粘液便,后来转化为脓血便,经就医检查后确诊为直肠炎。住院服用西药,灌肠等治疗均有效,但停药后,胃肠稍受刺激就会复发。经使用下述配发:
柴胡6g、扁豆6g、香附6g、枳实10g、半夏6g、茯苓6g、干姜10g、黄连10g、乌梅15g、木通3g、甘草2g、葛根6g。将上述中药料混合后,熬成草药汤剂服用,早晚各一次。
服药十天后,患者大便就成形,大便次数减少;服药一个月后脓血便现象消失;服药两个月后去医院检查,肠粘膜恢复正常;继续巩固服药一个月,患者痊愈,未再复发。
典型病例2:张某,男,42岁,用药两周前脐周围肿痛,感觉恶心、厌食,自认为是胃痛。后来出现发烧,连日不退,且大便不通,经肌注青霉素3天,未见好转,表现为神志不清,精神萎顿,表情漠然。经诊治,其腹壁紧张、压痛,肌肤甲错,右下肢拳曲而卧,脉象沉细,舌苔根薄而黄腻。经使用下述配发:
柴胡15g、扁豆15g、香附15g、枳实20g、半夏15g、茯苓15g、干姜15g、黄连15g、乌梅20g、木通6g、甘草4g、葛根15g。将上述中药料混合后,熬成草药汤剂服用,早晚各一次。
服用本发明药物一周,患者大便通畅,腹部痛感渐轻,腹壁紧张感变缓,压痛消弱,开始少量饮食;10日后,腹痛轻微,体温渐趋正常,胃纳转馨;服用本组合药物20日,体征恢复正常,患者痊愈。
典型病例3:赵某,男,52岁,临床病症为排便不规律,大便变形、变细、里急后重、便血量大,腹部时有痛感,伴有体重减轻、精神不振、食欲下降,据悉曾患有直肠炎。由于间断性腹部绞痛加重,到医院就医一段时间后,以上症状并未减轻,后被确诊为直肠癌。患者面临巨大的身体痛苦和精神压力,由于就医的经济压力过大,患者遂回家休养。后以尝试的心态使用了下属中药配方:
柴胡10g、扁豆10g、香附10g、枳实15g、半夏10g、茯苓6g、干姜13g、黄连13g、乌梅18g、木通5g、甘草3g、葛根10g。将上述中药料混合后,熬成草药汤剂服用,早晚各一次。
服用本药物1个月后,患者便血情况减缓,便血次数减少,食欲稍增;3个月后,里急后重的情况明显减少,腹痛的间隔时间变长,大便成形、颜色变浅;8个月后,患者饭量增加,身上感觉有劲了,逐渐精神起来,其他症状基本消失;继续巩固服用本组合药,1年后,患者体重较病前有所增加,所有症状消失。
最后说明的是,以上实施例仅用以说明本发明的技术方案而非限制,尽管参照较佳实施例对本发明进行了详细说明,本领域的普通技术人员应当理解,可以对本发明的技术方案进行修改或者等同替换,而不脱离本发明技术方案的宗旨和范围,其均应涵盖在本发明的权利要求范围当中。
Claims (10)
1.适用于肠炎的中药组合物,其特征在于,由以下重量份的原药制成:柴胡6—15份、扁豆6—15份、香附6—15份、枳实10—20份、半夏6—15份、茯苓6—15份、干姜10—15份、黄连10—15份、乌梅15—20份、木通3—6份、甘草2—4份、葛根6—15份。
2.根据权利要求1所述的适用于肠炎的中药组合物,其特征在于,由以下重量份的原药制成:柴胡10份、扁豆10份、香附10份、枳实15份、半夏10份、茯苓6—15份、干姜13份、黄连13份、乌梅18份、木通5份、甘草3份、葛根10份。
3.权利要求1或2任一项所述的中药组合物在制备用于治疗直肠炎的药物中的应用。
4.权利要求1或2任一项所述的中药组合物在制备用于治疗盲肠炎的药物中的应用。
5.权利要求1或2任一项所述的中药组合物在制备用于抑制直肠癌的药物中的应用。
6.权利要求1或2任一项所述的适用于肠炎的中药组合物的制剂,其特征在于,所述中药组合物的剂型为散剂、片剂、草药汤剂或口服液制剂。
7.根据权利要求6所述的中药组合物的制剂,其特征在于,所述中药组合物散剂的制备方法,包括以下步骤:
1)粉碎:将所述组份按配比混合,投入粉碎机粉碎成细粉,至粒度为80—110目;
2)混合:将步骤1)所得细粉投入混合搅拌机充分混合;
3)加热:将步骤2)所得在65—80℃下加热25—40分钟;
4)储存:将步骤3)所得冷却后,袋装或瓶装,置放于阴凉干燥处。
8.根据权利要求6所述的中药组合物的制剂,其特征在于,所述中药组合物的草药汤剂的制备方法,包括以下步骤:
1)备料:将所述组份按配比混合后碾碎,每剂中药饮片不长于3cm;
2)浸泡:将步骤1)所得置于煎药容器,用冷水中浸泡20—30分钟,用水量浸过药面1—3cm;
3)煎药:将步骤2)所得先用猛火煎至充分沸腾1—3分钟,然后收至文火,煎30-60分钟;
4)用药:将步骤3)所得用消毒纱布过滤得所需药液,倒入杯内,温热服用。
9.根据权利要求8所述的中药组合物的制剂,其特征在于,所述煎药容器为砂锅或搪瓷器皿。
10.根据权利要求8所述的中药组合物的制剂,其特征在于,煎药所用的水为凉开水、井水或者泉水。
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