CN103071060B - Traditional Chinese medicine preparation for treating ankylosing spondylitis - Google Patents
Traditional Chinese medicine preparation for treating ankylosing spondylitis Download PDFInfo
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- CN103071060B CN103071060B CN201310015033.9A CN201310015033A CN103071060B CN 103071060 B CN103071060 B CN 103071060B CN 201310015033 A CN201310015033 A CN 201310015033A CN 103071060 B CN103071060 B CN 103071060B
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating ankylosing spondylitis. The traditional Chinese medicine preparation is prepared from the following raw materials in part by weight: 2-7 parts of radix dipsaci, 5-7 parts of eucommia ulmoides oliv, 3-7 parts of rhizoma drynariae, 3-6 parts of rhizoma cibotii, 2-5 parts of rhizoma polygonati, 1-3 parts of the fruit of Chinese wolfberry, 1-4 parts of parasitic loranthus, 1-3 parts of gastrodia elata, 1-5 parts of radix angelicae pubescentis and 3-8 parts of golden cypress. According to the invention, each raw material can effectively give play to an effect of notifying the kidney and straightening the waist through differential compatibility so as to achieve a purpose of treating the ankylosing spondylitis; and the traditional Chinese medicine preparation disclosed by the invention has the advantages of good curative effect, low cost and no toxic and side effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation that is used for the treatment of ankylosing spondylitis, belong to the field of Chinese medicines.
Background technology
Ankylosing spondylitis (Ankylosing Spondylitis, AS) is a kind of chronic progressive disease, mainly invades sacroiliac joint, spinal column apophysis, the other soft tissue of spinal column and periphery joint, and the extra-articular manifestation that can occur together.Hidden the attacking of primary disease morbidity.Patient engenders lower back or sacroiliac pain and/or sends out stiffly, and half nyctalgia is waken up, and stands up difficulty, rise morning or sitting after play immediately waist and send out obviously stiffly, but alleviate after activity.Some patients feel buttocks dull pain or sacroiliac severe pain, radiate once in a while to periphery.Cough, sneeze, twist flank pain suddenly and can increase the weight of.Disease early pain is many is discontinuity in a side, and after the several months, pain is many is persistence at bilateral.With disease progression, by lumbar vertebra, to breast cervical spine, developed, occur corresponding site pain, limitation of activity or deformity of spine.Can there is deformity of spine and ankylosis in severe patient.Become the disease of serious harm human body health.
China's prevalence preliminary survey is 0.26%.Thought that primary disease male was common, men and women's ratio is 10.6:1 in the past; The ratio of now reporting men and women is 5:1, only women morbidity slowly and the state of an illness lighter.Age of onset is conventionally at 13~31 years old, after 30 years old and within 8 years old, to send out in the past patient rare.
The medicine for the treatment of ankylosing spondylitis has non-steroidal anti-inflammatory drugs, slow-acting drug, glucocorticoid, biological preparation, Chinese patent medicine etc. at present.Non-steroidal anti-inflammatory drugs, in treatment AS, played positive role, but the gastrointestinal side effect of medicine makes it in clinical practice, be subject to larger restriction to improving patient's quality of life.Slow-acting drug is brought into play certain effect slowing down and stop aspect disease progression, but except digestive tract side effects, also has hepatorenal damage, bone marrow depression, lung damage etc.Glucocorticoid is to AS, more harm than good, generally not conventional use.The biological preparation of coming in, can better control the state of an illness, but increases infection chance, and expensive, is very restricted.
Treatment by Chinese herbs ankylosing spondylitis has unique curative effect and advantage, and because Chinese medicine great majority have no side effect, untoward reaction is little, so treatment by Chinese herbs ankylosing spondylitis is more and more concerned.
Summary of the invention
Based on above-mentioned technical problem, the invention provides a kind of Chinese medicine preparation for the treatment of ankylosing spondylitis.
Its technical solution is:
Treat a Chinese medicine preparation for ankylosing spondylitis, it is to be made by the crude drug of following weight portion:
Radix Dipsaci 2-7 part, Cortex Eucommiae 5-7 part, Rhizoma Drynariae 3-7 part, Rhizoma Cibotii 3-6 part, Rhizoma Polygonati 2-5 part, Fructus Lycii 1-3 part, Herba Taxilli 1-4 part, Rhizoma Gastrodiae 1-3 part, Radix Angelicae Pubescentis 1-5 part, Cortex Phellodendri 3-8 part.
Preparation method is as follows:
A takes respectively Radix Dipsaci, the Cortex Eucommiae, Rhizoma Drynariae, Rhizoma Cibotii, Rhizoma Polygonati, Fructus Lycii, Herba Taxilli, Rhizoma Gastrodiae, Radix Angelicae Pubescentis and Cortex Phellodendri according to above-mentioned weight portion proportioning;
B adds 8 times of weight water soakings 1 hour by load weighted crude drug Radix Dipsaci, the Cortex Eucommiae, Rhizoma Drynariae, Rhizoma Cibotii, Rhizoma Polygonati and Fructus Lycii, then decocts 40 minutes, filters, and obtains filtrate one and medicinal residues; The another device of filtrate one stores, and medicinal residues add 4 times of weight water again, decocts 60 minutes, filters, and obtains filtrate two;
C mixes filtrate one with filtrate two, be condensed into relative density and be 1.20-1.35 thick paste at 80 ℃;
D is broken into medicamental pulverata by residue 4 taste crude drug Herba Taxillis, Rhizoma Gastrodiae, Radix Angelicae Pubescentis and Cortex Phellodendri powder, in the thick paste that then medicamental pulverata is added step c to make, mixes and makes soft material.
Further, available pellet processing machine is processed into concentrated pill by the soft material making in steps d.
In addition, above-mentioned Chinese medicine preparation also can be made into decoction, and preparation method is as follows:
The crude drug of above-mentioned weight portion is put into medicine decocting tank in the lump, soak, amount of water is advisable to surpass liquid level 2~3cm; Then boil with high heat, then use slow fire instead and decoct.When decocting into 180-200 milliliter medicine juice for every dose, stop, elimination medicinal residues, take concoction.
Pharmacology of the present invention and effect are as follows:
Ankylosing spondylitis belongs to caused by liver and kidney deficiency card.Card is shown in: lumbosacral region, lower back limitation of activity, and pain, morning is stiff, talalgia, soreness of the waist and knees, limbs are tired, and extremities joint swells and ache, xerostomia.Red tongue, white and thin fur or slightly yellow, deep-thready pulse, or heavy sliding.In the crude drug that the present invention chooses: Radix Dipsaci has invigorating the liver and kidney, sharp joint, the effect of invigorating blood circulation; The Cortex Eucommiae has invigorating the liver and kidney, bone and muscle strengthening, the effect of blood pressure lowering; Rhizoma Drynariae has the kidney invigorating bone strengthening, continuous effect of hindering pain relieving; Rhizoma Cibotii has invigorating the liver and kidney, except rheumatism, and strong waist foot, the effect in sharp joint; Rhizoma Polygonati has boosting qi and nourishing yin, spleen invigorating, lung moistening, the effect of kidney tonifying; Fructus Lycii has function for tonifying kidney; Herba Taxilli has invigorating the liver and kidney, the effect of bone and muscle strengthening; Rhizoma Gastrodiae has suppressing the hyperactive liver to relieve the wind syndrome, the effect of wind-expelling pain-stopping; Radix Angelicae Pubescentis has expelling wind and dampness, the effect of dispersing cold for relieving pain; Cortex Phellodendri has heat clearing and damp drying, and eliminating fire and detoxication, except the effect of hectic fever due to YIN-deficiency clearind deficient heat.Above-mentioned raw materials medicine, through dialectical compatibility, can effectively have been given play to the effect of replenishing kidney, strengthening waist, to reach the object of curing ankylosing spondylitis, and good effect, expense is low, has no side effect.
Clinical data
According to the New York diagnosing ankylosing spondylitis standard (1984) of revision, select outpatient service, inpatient totally 100 examples, according to random method, be divided into each 50 examples for the treatment of group and matched group.In treatment group, male 41 examples, female's 9 examples, 19 years old-50 years old age; In matched group, male 42 examples, female's 8 examples, 19 years old-50 years old age.At aspects such as the state of an illness, sex, age, the courses of disease, learn by statistics processing no significant difference for two groups.
Case inclusion criteria: the course of disease of 1. descending lumbago and backache at least continues 3 months, pain is with improving action, but can not alleviate after having a rest; 2. lumbar vertebra is at front and back and lateroflexion direction limitation of activity; 3. thorax expands the normal value that is less than same age and sex in scope; 4. bilateral sacroiliitis II~IV level.If 4. patient possesses and respectively additional 1.~in 3. any one can be diagnosed as ankylosing spondylitis.
Therapeutic Method
Matched group: leflunomide 10mg/d, sulfasalazine enteric coatel tablets 1.0g/ time, every day 2 times, celecoxib capsule 0.2g/ time, twice of every day is oral.Treatment group adds with medicine decoction of the present invention on matched group medication basis, every day 2 times.It within 3 months, is a course for the treatment of.
Observation index and method
Standard with reference to < < new Chinese medicine guideline of clinical investigations > >.Effective: cardinal symptom, whole improvement rate >=75% of sign, erythrocyte sedimentation rate, CRP normally or obviously improve or approach normal; Progressive: cardinal symptom, sign improvement rate >=50%, erythrocyte sedimentation rate, CRP are improved; Effective: whole improvement rate >=30% of cardinal symptom, sign, erythrocyte sedimentation rate, CRP are improved or without improvement; Invalid: cardinal symptom, sign improvement rate < 30%, erythrocyte sedimentation rate, CRP are without improvement.Effective 20 examples for the treatment of group (adding by medicine group of the present invention), progressive 18 examples, effective 12 examples, invalid 0 example, obvious effective rate 40%, total effective rate 100%; Effective 14 examples of matched group, progressive 17 examples, effective 13 examples, invalid 6 examples, obvious effective rate 28%, total effective rate 88%.Between two groups, difference has very significant, and treatment group is obviously better than matched group.
The specific embodiment
Embodiment 1
A kind of Chinese medicine for the treatment of ankylosing spondylitis, adopt the crude drug of following weight portion proportioning to be prepared from, crude drug comprises 2 parts of Radix Dipsacis, 5 parts of the Cortexs Eucommiae, 3 parts of Rhizoma Drynariae, 3 parts of Rhizoma Cibotii, 2 parts of Rhizoma Polygonatis, 1 part of Fructus Lycii, 1 part of Herba Taxilli, 1 part, Rhizoma Gastrodiae, 1 part of Radix Angelicae Pubescentis, 3 parts of Cortex Phellodendris.
Preparation method is as follows: first load weighted material medicine Radix Dipsaci, the Cortex Eucommiae, Rhizoma Drynariae, Rhizoma Cibotii, Rhizoma Polygonati, Fructus Lycii are added to 8 times of weight water soakings 1 hour, decoct 40 minutes, filter, obtain filtrate one and medicinal residues.The another device of filtrate one stores, and medicinal residues add 4 times of weight water again, boils 60 minutes, filters, and obtains filtrate two.Filtrate one is mixed with filtrate two, and at 80 ℃, being concentrated into relative density is 1.20-1.35 thick paste, and other weight portion medicine Herba Taxillis, Rhizoma Gastrodiae, Radix Angelicae Pubescentis and Cortex Phellodendri are ground into respectively medicamental pulverata, then mix, and last and thick paste mixes and makes soft material with blender.
Embodiment 2
A kind of Chinese medicine for the treatment of ankylosing spondylitis, adopt the crude drug of following weight portion proportioning to be prepared from, crude drug comprises 5 parts of Radix Dipsacis, 6 parts of the Cortexs Eucommiae, 5 parts of Rhizoma Drynariae, 4.5 parts of Rhizoma Cibotii, 4 parts of Rhizoma Polygonatis, 2 parts of Fructus Lycii, 3 parts of Herba Taxillis, 2 parts, Rhizoma Gastrodiae, 3 parts of Radix Angelicae Pubescentiss, 5 parts of Cortex Phellodendris.
Preparation method is as follows: first load weighted material medicine Radix Dipsaci, the Cortex Eucommiae, Rhizoma Drynariae, Rhizoma Cibotii, Rhizoma Polygonati, Fructus Lycii are added to 8 times of weight water soakings 1 hour, decoct 40 minutes, filter, obtain filtrate one and medicinal residues.The another device of filtrate one stores, and medicinal residues add 4 times of weight water again, boils 60 minutes, filters, and obtains filtrate two.Filtrate one is mixed with filtrate two, at 80 ℃, be concentrated into the thick paste that relative density is 1.20-1.35, other weight portion medicine Herba Taxillis, Rhizoma Gastrodiae, Radix Angelicae Pubescentis and Cortex Phellodendri are ground into respectively medicamental pulverata, then mix, last and thick paste mixes and makes soft material with blender, then makes concentrated pill with pellet processing machine.
Embodiment 3
A kind of Chinese medicine for the treatment of ankylosing spondylitis, adopt the crude drug of following proportioning to be prepared from, crude drug comprises 7 parts of Radix Dipsacis, 7 parts of the Cortexs Eucommiae, 7 parts of Rhizoma Drynariae, 6 parts of Rhizoma Cibotii, 5 parts of Rhizoma Polygonatis, 3 parts of Fructus Lycii, 4 parts of Herba Taxillis, 3 parts, Rhizoma Gastrodiae, 5 parts of Radix Angelicae Pubescentiss, 8 parts of Cortex Phellodendris.
Material medicine Radix Dipsaci, the Cortex Eucommiae, Rhizoma Drynariae, Rhizoma Cibotii, Rhizoma Polygonati, Fructus Lycii are added to 8 times of weight water soakings 1 hour, decoct 40 minutes, filter, obtain filtrate one and medicinal residues.The another device of filtrate one stores, and medicinal residues add 4 times of weight water again, boils 60 minutes, filters, and obtains filtrate two.Filtrate one is mixed with filtrate two, at 80 ℃, being concentrated into relative density is 1.20-1.35 thick paste, and other weight portion medicine Herba Taxillis, Rhizoma Gastrodiae, Radix Angelicae Pubescentis and Cortex Phellodendri are ground into respectively medicamental pulverata, then mix, last and thick paste mixes and makes soft material with blender, then makes concentrated pill with pellet processing machine.
Claims (1)
1. treat a Chinese medicine preparation for ankylosing spondylitis, it is characterized in that being made by the crude drug of following weight portion:
Radix Dipsaci 2-7 part, Cortex Eucommiae 5-7 part, Rhizoma Drynariae 3-7 part, Rhizoma Cibotii 3-6 part, Rhizoma Polygonati 2-5 part, Fructus Lycii 1-3 part, Herba Taxilli 1-4 part, Rhizoma Gastrodiae 1-3 part, Radix Angelicae Pubescentis 1-5 part, Cortex Phellodendri 3-8 part.
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CN104225532B (en) * | 2014-09-12 | 2018-03-16 | 郑州中医骨伤病医院 | Treat the jianpiwenshen pills of ankylosing spondylitis |
CN104784481A (en) * | 2015-03-30 | 2015-07-22 | 王艳菊 | Traditional Chinese medicine preparation for treating ankylosing spondylitis and nursing method |
CN107088207A (en) * | 2016-02-18 | 2017-08-25 | 魏晓露 | It is a kind of to treat Chinese medicine composition of ankylosing spondylitis and its preparation method and application |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1682811A (en) * | 2005-02-22 | 2005-10-19 | 黄资源 | Ridge and bone strengthening pill for treating ankylosing spondylitis |
CN102125625A (en) * | 2010-01-20 | 2011-07-20 | 甄洪亮 | Traditional Chinese medicine for treating ankylosing spondylitis |
CN102764393A (en) * | 2011-05-01 | 2012-11-07 | 闫凤宝 | Medicine for treating ankylosing spondylitis |
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CN1682811A (en) * | 2005-02-22 | 2005-10-19 | 黄资源 | Ridge and bone strengthening pill for treating ankylosing spondylitis |
CN102125625A (en) * | 2010-01-20 | 2011-07-20 | 甄洪亮 | Traditional Chinese medicine for treating ankylosing spondylitis |
CN102764393A (en) * | 2011-05-01 | 2012-11-07 | 闫凤宝 | Medicine for treating ankylosing spondylitis |
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