CN103063856A - Full-automatic fecal occult blood analyzer - Google Patents
Full-automatic fecal occult blood analyzer Download PDFInfo
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- CN103063856A CN103063856A CN2013100005937A CN201310000593A CN103063856A CN 103063856 A CN103063856 A CN 103063856A CN 2013100005937 A CN2013100005937 A CN 2013100005937A CN 201310000593 A CN201310000593 A CN 201310000593A CN 103063856 A CN103063856 A CN 103063856A
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Abstract
The invention relates to a full-automatic fecal occult blood analyzer, and belongs to measurement devices used for immunization test. The analyzer comprises a main case, an upper cover, a reaction disc component, a sample disc component, a reagent loading bracket, a probe component, a mechanical arm component and a base plate, wherein the probe component and the mechanical arm component are connected with the base plate respectively. The full-automatic fecal occult blood analyzer has the advantages that the full-automatic sample detection can be realized, the test velocity is fast, the possibility that a tester comes into contact with the sample is lowered, so that the environmental protection is facilitated and the hemoglobin concentration in excrement can be measured quantitatively.
Description
Technical field
The present invention relates to the measurement mechanism for the immunization test.
Background technology
The fecal occult blood test item is one of medical laboratory's routine inspection project, and be regarded as checking clinically that hemorrhage of digestive tract and enteron aisle worsen one of the most frequently used index of tumour, not only diagnosis, antidiastole, the observation of curative effect of disease and the post analysis of healing there are important clinical meaning, and the assessment of health status is also had certain value.
At present fecal occult blood analytical review mainly contains two kinds of methods:
1), chemical method: chemical method has benzidine method, ortho-aminotoluene method, leucobase of malachite green method, guaiaci lignum, pyramidon method etc., and is comparatively practical with the ortho-aminotoluene method.Its principle makes its release new ecological oxygen based on the hydrogen peroxide of the iron content protoheme in the haemoglobin in can catalytic reagent, the above-mentioned chromogen substance of oxidation and developing the color.What of haemoglobin are the depth of colour developing reacted, that is the size of amount of bleeding.Although chemical method is simple, lack specificity on the method.Be subjected to diet and drug influence larger, resultant error is also larger.This method that adopts has seldom been arranged now.
2), immunization: immunological method, such as immune monoclonal antibody method, enzyme linked immunosorbent assay, immune spot-ing, latex immunochemistry coacervation, radioimmunodiffusion, oppositely brief introduction Hemagglutination Method, colloid gold label sandwich immunoassay method of inspection etc.This type of is tested used antibody and is divided into two large classes, i.e. antihuman hemoglobin antibody and anti-human erythrocyte matrix antibody.Single antibody act is to solve in recent years the immunological method that occult blood experiment comparatively generally adopts and very high specificity is arranged, and does not need to keep on a diet.By a kind of method comparatively confirmed of world health organisation recommendations as occult blood test.
More than two kinds of methods also need at present clinically operating personnel to carry out stirring behind hand sampling, the dilute with water, get supernatant, the test strips that will detect again usefulness immerses, then its change color of visual inspection is come the yin and yang attribute of judgement sample, 1), specimen sample, dilution, test strips soak, observe there is following shortcoming though the method is simple:, all manually-operateds can not realize robotization, speed is slow, efficient is low; 2), operating personnel contact with sample and cause easily cross pollution, and are also easily offensive in vision and sense of smell, and are unfavorable for environmental protection; 3), measurement sensitivity is low, micro-occult blood can't detect, and can only qualitative analysis can not quantitatively detect.
Summary of the invention
The invention provides a kind of full-automatic fecal occult blood analyser, with solve the efficient that present manual inspection method exists low, easily pollute and inaccurate problem.
The technical solution used in the present invention is:
Comprise casing and loam cake, reaction tray assembly, sample disk assembly, reagent loading dock, probe assembly is fixedly connected with base plate respectively with mechanical arm assembly,
The structure of described reaction tray assembly is: round turntable is connected by belt with the first rotary drive mechanism, arrange 40 disposal reaction cups changing on the circumference of described round turntable, be fixedly connected with the optical measurement mechanism that reaction cup is carried out turbidimetry on the below base plate of rotating disk;
Described the first rotary drive mechanism drives rotating disk and realizes the rotation location, the reaction cup of assigned address is stopped at reagent adding position, application of sample position, stirs position, reaction cup change bit and optical measurement position, and reagents pin and sample needle application of sample, stirring rod stir, reaction cup is changed, operation is measured by optical measurement mechanism;
The structure of described sample disk assembly is: the sample storage frame is connected by belt with the second rotary drive mechanism, the inner ring of described sample storage frame, outward respectively be evenly arranged in circle hole and an outer circle hole;
Described the second rotary drive mechanism drives the sample storage frame and realizes the rotation location, and interior circle hole and the outer circle hole of assigned address is stopped at the suction sample position, cooperates sample needle to finish the suction sample;
Described reagent loading dock is used for loaded reagent, and the wait reagent needles is drawn reagent;
The structure of described probe assembly is: specimen needle is fixedly connected with the first mechanical arm with reagent needles, and the first mechanical arm is connected with the first driver module, and the probe service sink is fixedly connected with base plate, and fixedly stirring rod is fixedly connected with the second mechanical arm;
Described probe assembly is used for finishing application of sample, reagent adding, the stirring operation of test event, also can finish the cleaning operation of sample needle, reagent needles, stirring rod, described stirring rod links to each other with direct current generator, direct current generator drives stirring rod and does the Stirring motion, and described stirring rod makes it even mixing for the reactant liquor in the reaction cup is stirred;
The structure of the first driver module is in the described probe assembly: motor one is fixedly connected with base plate, motor one drives spline by synchronizing wheel one, synchronizing wheel two and Timing Belt, fixed head is by column and base plate, motor two is fixedly connected with fixed head, motor two is connected with leading screw by synchronizing wheel three, synchronizing wheel four-function Timing Belt, leading screw is by screw set and spline joint, and spline is fixedly connected with the first mechanical arm, the second mechanical arm.
Described mechanical arm assembly comprises mechanical grip and drives the second driver module that jaw moves; Described mechanical grip is loaded in the new reaction cup on the round turntable.
The object of the invention is to improve the efficient of clinical examination, and full-automatic clinical detection replaces manual operations, improves measuring accuracy, accuracy, sensitivity, and carrying out the qualitative analysis that quantitative test replaces in the past provides valuable occult blood analysis indexes for clinical.
The present invention has following advantage:
1, sample dilution, result detect whole realization robotizations, speed is fast, efficient is high;
2, operating personnel do not contact with sample, and the sample of trace can not allow the people feel nauseating in vision and sense of smell, and can avoid cross pollution also to be beneficial to environmental protection.
3, measurement sensitivity is high, and micro-occult blood also can accurately detect, and can quantitatively detect as clinical valuable occult blood analysis indexes is provided.
Description of drawings
Fig. 1 is structural representation of the present invention;
Fig. 2 is reaction tray assembly of the present invention, sample disk assembly, reagent loading dock, the structural representation of probe assembly and mechanical arm assembly, base plate 2;
Fig. 3 is the structural representation of the first driver module 24 in the probe assembly 4 of the present invention.
Embodiment
The structure of described reaction tray assembly 1 is: round turntable 6 is connected by belt with the first rotary drive mechanism 7, arrange 40 disposal reaction cups 8 changing on the circumference of described round turntable 6, be fixedly connected with the optical measurement mechanism 9 that reaction cup 8 is carried out turbidimetry on the below base plate 25 of rotating disk 6;
Described the first rotary drive mechanism 7 drives rotating disk 6 and realizes the rotation location, the reaction cup 8 of assigned address is stopped at reagent adding position, application of sample position, stirs position, reaction cup change bit and optical measurement position, and reagents pin and sample needle application of sample, stirring rod stir, reaction cup is changed, operation is measured by optical measurement mechanism; A branch of directional light passes from reaction cup in the measurement passage of described optical measurement mechanism, thereby makes above-mentioned reaction cup finish turbidimetry;
The structure of described sample disk assembly 2 is: sample storage frame 10 is connected by belt with the second rotary drive mechanism 11, the inner ring of described sample storage frame 10, respectively is evenly arranged 40 interior circle holes 21 and outer circle hole 20 outward;
Described the second rotary drive mechanism 11 drives sample storage framves 10 and realizes the rotation location, and interior circle hole 21 and the outer circle hole 20 of assigned address is stopped at the suction sample position, cooperates sample needle to finish the suction sample;
Described reagent loading dock 3 is used for loaded reagent, and wait reagent needles 14 is drawn reagent;
The structure of described probe assembly 4 is: specimen needle 13 is fixedly connected with the first mechanical arm 15 with reagent needles 14, the first mechanical arm 15 is connected with the first driver module 24, probe service sink 16 is fixedly connected with base plate 25, and fixedly stirring rod 17 is fixedly connected with the second mechanical arm 18;
Described probe assembly 4 is used for finishing application of sample, reagent adding, the stirring operation of test event, also can finish the cleaning operation of sample needle, reagent needles, stirring rod, described stirring rod 17 links to each other with direct current generator 12, direct current generator drives stirring rod 17 and does the Stirring motion, and described stirring rod 17 makes it even mixing for the reactant liquors in the reaction cup 8 are stirred;
The structure of the first driver module 24 is in the described probe assembly 4: motor 1 is fixedly connected with base plate 25, motor 1 drives spline 40 by synchronizing wheel 1, synchronizing wheel 2 29 and Timing Belt 28, fixed head 36 is by column 32 and base plate 25, motor 2 33 is fixedly connected with fixed head 36, motor 2 33 is connected with leading screw 38 by synchronizing wheel 3 34, synchronizing wheel 4 37 usefulness Timing Belts 35, leading screw 38 is connected connection by screw set 39 with spline, spline 40 is fixedly connected with the first mechanical arm 15, the second mechanical arm 18.
Described mechanical arm assembly 5 comprises mechanical grip 19 and drives the second driver module 31 that jaw moves; Described mechanical grip 19 is loaded in new reaction cup 8 on the round turntable 6.
The control circuit that the present invention is used for and control software thereof are prior art, no longer describe in detail here.
Using method of the present invention is as follows:
A, instrument start, system initialization specifically comprises: reaction tray assembly 1, sample disk assembly 2, probe assembly 4 and mechanical arm assembly 5 carry out mechanical return, and optical measurement mechanism 9 illuminators power on, and then just allow to begin test;
B, system prompt are placed the new reaction cup in reaction tray;
C, the from the 1st to the 2nd work period, reagent needles 14 is drawn reagent and is injected 1 to No. 2 reaction cup and draw reagent from reagent bottle from reagent bottle within each work period, then reagent is injected reaction cup, cleaning reagent pin 14 after each application of sample is finished;
D, in the 3rd work period, specimen needle is drawn sample and is injected reaction cup No. 1 from sample tube, cleaning specimen needle 13 after application of sample is finished;
E, in the 4th work period, stirring rod is inserted in No. 1 reaction cup and is stirred and evenly mixed, stir finish after the cleaning stirring rod;
F, after the 4th work period, reagent needles 14 is drawn reagent, specimen needle 13 is drawn samples, then simultaneously in different reaction cup reagent adding, add sample and stirring;
G, in the 6th work period, the reactant liquor in 9 pairs of reaction cup of optical measurement mechanism carries out turbidimetry, carries out photometry first time, carries out photometry second time the 21st work period, measurement result is also exported in calculating;
H, carry out reaction cup the 22nd work period and change.
Claims (1)
1. full-automatic fecal occult blood analyser is characterized in that: comprise casing and loam cake, and reaction tray assembly, sample disk assembly, reagent loading dock, probe assembly is fixedly connected with base plate respectively with mechanical arm assembly,
The structure of described reaction tray assembly is: round turntable is connected by belt with the first rotary drive mechanism, arrange 40 disposal reaction cups changing on the circumference of described round turntable, be fixedly connected with the optical measurement mechanism that reaction cup is carried out turbidimetry on the below base plate of rotating disk;
The structure of described sample disk assembly is: the sample storage frame is connected by belt with the second rotary drive mechanism, the inner ring of described sample storage frame, outward respectively be evenly arranged in circle hole and an outer circle hole;
The structure of described probe assembly is: specimen needle is fixedly connected with the first mechanical arm with reagent needles, and the first mechanical arm is connected with the first driver module, and the probe service sink is fixedly connected with base plate, and fixedly stirring rod is fixedly connected with the second mechanical arm;
The structure of the first driver module is in the described probe assembly: motor one is fixedly connected with base plate, motor one drives spline by synchronizing wheel one, synchronizing wheel two and Timing Belt, fixed head is by column and base plate, motor two is fixedly connected with fixed head, motor two is connected with leading screw by synchronizing wheel three, synchronizing wheel four-function Timing Belt, leading screw is by screw set and spline joint, and spline is fixedly connected with the first mechanical arm, the second mechanical arm;
Described mechanical arm assembly comprises mechanical grip and drives the second driver module that jaw moves; Described mechanical grip is loaded in the new reaction cup on the round turntable.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310000593.7A CN103063856B (en) | 2013-01-04 | 2013-01-04 | Full-automatic fecal occult blood analyzer |
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| CN201310000593.7A CN103063856B (en) | 2013-01-04 | 2013-01-04 | Full-automatic fecal occult blood analyzer |
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| CN103063856A true CN103063856A (en) | 2013-04-24 |
| CN103063856B CN103063856B (en) | 2014-04-30 |
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103344643A (en) * | 2013-07-05 | 2013-10-09 | 深圳普门科技有限公司 | Semi-automatic external detection equipment and method for measuring specific egg white by turbidimetry |
| CN103439522A (en) * | 2013-09-04 | 2013-12-11 | 深圳市锦瑞电子有限公司 | Specific protein analyzer |
| CN103433256A (en) * | 2013-09-04 | 2013-12-11 | 深圳市锦瑞电子有限公司 | Cleaning device and cleaning method for sampling needle of specific protein analysis meter |
| CN103808718A (en) * | 2014-03-06 | 2014-05-21 | 济南齐力医疗器械有限公司 | Multichannel biochemical analyzer |
| CN106018521A (en) * | 2016-08-05 | 2016-10-12 | 苏州天键衡电子信息科技有限公司 | Acidity and alkalinity continuous detection apparatus |
| CN108132179A (en) * | 2016-03-17 | 2018-06-08 | 梁怡芃 | A kind of inspection fecal content object automatic pretreatment apparatus |
| CN109212234A (en) * | 2018-08-31 | 2019-01-15 | 深圳市国赛生物技术有限公司 | A kind of POCT glycolated hemoglobin analysis and POCT glycosylated hemoglobin analysis system |
| CN109406799A (en) * | 2017-08-16 | 2019-03-01 | 北京普利生仪器有限公司 | Sample analysis apparatus, reagent adding device, and control method thereof |
| CN109470836A (en) * | 2018-10-23 | 2019-03-15 | 中国科学院合肥物质科学研究院 | A kind of Soil K+adsorption alkali-hydrolyzable nitrogen batch detection device |
| CN110456088A (en) * | 2019-08-27 | 2019-11-15 | 前海奥斯韦尔生物科技(深圳)有限公司 | Specific protein analyzer |
| US10684300B2 (en) | 2015-10-30 | 2020-06-16 | W.H.P.M Bioresearch and Technology Co., Ltd. | Rotating disc type fecal occult blood detection analyzer |
| CN114486660A (en) * | 2022-01-27 | 2022-05-13 | 山西医科大学第二医院 | Intestinal tract preparation evaluation detection device and method for patient before enteroscopy |
| CN115436650A (en) * | 2022-11-08 | 2022-12-06 | 山东康华生物医疗科技股份有限公司 | Full-automatic colloidal gold analyzer |
| CN115616236A (en) * | 2022-11-08 | 2023-01-17 | 山东康华生物医疗科技股份有限公司 | Gold mark instrument |
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| CN1866028A (en) * | 2006-04-21 | 2006-11-22 | 珠海森龙生物科技有限公司 | Linkage system of sample charging mechanism of biochemical analyzer |
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Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103344643A (en) * | 2013-07-05 | 2013-10-09 | 深圳普门科技有限公司 | Semi-automatic external detection equipment and method for measuring specific egg white by turbidimetry |
| CN103439522A (en) * | 2013-09-04 | 2013-12-11 | 深圳市锦瑞电子有限公司 | Specific protein analyzer |
| CN103433256A (en) * | 2013-09-04 | 2013-12-11 | 深圳市锦瑞电子有限公司 | Cleaning device and cleaning method for sampling needle of specific protein analysis meter |
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| CN103808718A (en) * | 2014-03-06 | 2014-05-21 | 济南齐力医疗器械有限公司 | Multichannel biochemical analyzer |
| US10684300B2 (en) | 2015-10-30 | 2020-06-16 | W.H.P.M Bioresearch and Technology Co., Ltd. | Rotating disc type fecal occult blood detection analyzer |
| CN108132179A (en) * | 2016-03-17 | 2018-06-08 | 梁怡芃 | A kind of inspection fecal content object automatic pretreatment apparatus |
| CN108132179B (en) * | 2016-03-17 | 2020-05-12 | 巨爱宁 | Automatic pretreatment device for inspecting excrement content |
| CN106018521A (en) * | 2016-08-05 | 2016-10-12 | 苏州天键衡电子信息科技有限公司 | Acidity and alkalinity continuous detection apparatus |
| CN109406799A (en) * | 2017-08-16 | 2019-03-01 | 北京普利生仪器有限公司 | Sample analysis apparatus, reagent adding device, and control method thereof |
| CN109406799B (en) * | 2017-08-16 | 2022-03-04 | 北京普利生仪器有限公司 | Sample analysis apparatus, reagent adding device, and control method thereof |
| CN109212234A (en) * | 2018-08-31 | 2019-01-15 | 深圳市国赛生物技术有限公司 | A kind of POCT glycolated hemoglobin analysis and POCT glycosylated hemoglobin analysis system |
| CN109212234B (en) * | 2018-08-31 | 2021-07-20 | 深圳市国赛生物技术有限公司 | POCT (Point of Care testing) glycosylated hemoglobin analyzer and POCT glycosylated hemoglobin analysis system |
| CN109470836A (en) * | 2018-10-23 | 2019-03-15 | 中国科学院合肥物质科学研究院 | A kind of Soil K+adsorption alkali-hydrolyzable nitrogen batch detection device |
| CN110456088A (en) * | 2019-08-27 | 2019-11-15 | 前海奥斯韦尔生物科技(深圳)有限公司 | Specific protein analyzer |
| CN114486660A (en) * | 2022-01-27 | 2022-05-13 | 山西医科大学第二医院 | Intestinal tract preparation evaluation detection device and method for patient before enteroscopy |
| CN115436650A (en) * | 2022-11-08 | 2022-12-06 | 山东康华生物医疗科技股份有限公司 | Full-automatic colloidal gold analyzer |
| CN115616236A (en) * | 2022-11-08 | 2023-01-17 | 山东康华生物医疗科技股份有限公司 | Gold mark instrument |
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