CN103055417B - A kind of noinvasive transcutaneous electrostimulation instrument - Google Patents
A kind of noinvasive transcutaneous electrostimulation instrument Download PDFInfo
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- CN103055417B CN103055417B CN201210592267.5A CN201210592267A CN103055417B CN 103055417 B CN103055417 B CN 103055417B CN 201210592267 A CN201210592267 A CN 201210592267A CN 103055417 B CN103055417 B CN 103055417B
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Abstract
The invention discloses a kind of noinvasive percutaneous variable-frequency electric and stimulate multifunctional breath therapeutic instrument, comprising for monitoring breath state Real-Time Monitoring module, breath state when being in sleep state for Real-Time Monitoring monitored target, obtains sleep parameters; Electrical stimulation signal generation module, for providing at least two kinds of electrical stimulation pattern; Non-built-in mode percutaneous electrode, for conducting to the diaphram of monitored target or genioglossus by described chronic variable-frequency electric stimulus signal; Or described acute electrical stimulation signal is conducted to the diaphram of monitored target or genioglossus.It is multi-functional that this noinvasive percutaneous variable-frequency electric of the present invention stimulates multifunctional breath therapeutic instrument to integrate acute diaphragm pacing and the electricity irritation of chronic frequency conversion diaphram and acute genioglossus electricity irritation, the electricity irritation of chronic frequency conversion genioglossus etc., has treatment, prevention double effects.
Description
Technical field
The present invention relates to treatment chronic obstructive pulmonary disease (chronic obstructive pulmonary disease, etc. COPD) diaphragmatic fatigue caused and obstruction sleep apnea-hypopnea syndrome (Obstructive sleep apnea hypopnea syndrome, OSAHS), a kind of noinvasive transcutaneous electrostimulation instrument is particularly related to.
Background technology
COPD and OSAHS is commonly encountered diseases, frequently-occurring disease clinically, and all relates to and breathe some relevant skeletal muscle.The Oxygenation that respiratory muscle training can improve its night is carried out to COPD patient, alleviates dyspnea and improve respiratory muscle function, improving its mobility and quality of life simultaneously.External diaphragm pacing (External Ddiaphragm Pacemaker, EDP) is exactly the comparatively effective respiratory muscle training mode of one.At present, EDP treatment adopts persistence 2.5Hz or 10Hz electricity irritation compound physiologic frequency (40Hz) chronic electrical stimulation, can prevent and treat COPD diaphragmatic fatigue well, and can improve diaphragmatic function preferably.To OSAHS patient, due to epithelium healing relax, the narrow and small upper airway resistance caused increases is the factor that starts causing OSAHS, and Activities of Genioglossal Muscle is abnormal, pendant causes epithelium healing narrow after the root of the tongue is one of main reason, the length tension curve calibration ordinary person of genioglossus strengthens, namely effectively can reopen epithelium healing and stop the generation of obstructive respiration event, increasing of genioglossus EMG activity can significantly improve epithelium healing stability.Therefore, improve epithelium healing expansion muscle function and become the key for the treatment of this disease effectively and reasonably.Domestic have the percutaneous noinvasive double current impulsing stimulating instrument developed accordingly, can give patient's electricity irritation to promote the contraction of genioglossus immediately, at once improve ventilation when monitoring in sleep and having asphyxia to occur by program of just establishing, and stops asphyxia.
But above-mentioned two kinds of diseases likely exist, and are referred to as overlap syndrome simultaneously.And at present respectively for the therapeutic instrument function singleness of these two kinds of diseases, namely be merely able to provide a kind of electricity irritation for a kind of disease, and the electrical stimulation pattern of above-mentioned percutaneous noinvasive double current impulsing stimulating instrument is acute short-term symptomatic treatment, only there is interim open airway, recover the effect of breathing, without long-term treatment effects, also genioglossus contractility and anti-fatigue ability cannot be improved by treatment, more without the effect that prevention apnea occurs.Therefore, a kind of multifunction electric stimulation instrument electronic stimulation function of diaphragmatic fatigue and OSAHS united two into one is badly in need of now.
Summary of the invention
In view of this, the invention provides a kind of noinvasive transcutaneous electrostimulation instrument, it is by providing chronic variable-frequency electric stimulus modelity and acute electrical stimulation pattern, monitored target chronic variable-frequency electric stimulus signal or acute electrical stimulation signal can be given separately, also can give monitored target chronic variable-frequency electric stimulus signal and acute electrical stimulation signal simultaneously, namely the chronic variable-frequency electric that the diaphram that this therapeutic instrument can not only give the monitored target of suffering from copd is suitable for stimulates or acute electricity irritation, the chronic variable-frequency electric that the genioglossus also can suffering from the monitored target of OSAHS is suitable for stimulates or acute electricity irritation, namely the function of diaphragmatic fatigue and OSAHS electronic stimulation is combined, solve the problem of the function singleness of existing electro stimulation treatment apparatus.
The present invention is solved the problems of the technologies described above by following technological means:
The invention provides a kind of noinvasive transcutaneous electrostimulation instrument, comprising:
Real-Time Monitoring module, breath state when being in sleep state for Real-Time Monitoring monitored target, obtains sleep parameters;
Electrical stimulation signal generation module, for providing at least two kinds of electrical stimulation pattern, and when described monitored target is not in sleep state, start chronic variable-frequency electric stimulus modelity and produce chronic variable-frequency electric stimulus signal, or when described monitored target is in sleep state, judge that whether the breath state of described monitored target is normal according to the described sleep parameters analysis that Real-Time Monitoring obtains, if abnormal, then start acute electrical stimulation pattern and produce acute electrical stimulation signal;
Some non-built-in mode percutaneous electrodes, for conducting to the diaphram of described monitored target and/or genioglossus by described chronic variable-frequency electric stimulus signal; Or described acute electrical stimulation signal is conducted to the diaphram of described monitored target and/or genioglossus.
Implement beneficial effect of the present invention: the present invention by electricity irritation generation module when monitored target is not in sleep state, start chronic variable-frequency electric stimulus modelity and produce chronic variable-frequency electric stimulus signal, and by non-built-in mode percutaneous electrode, this chronic variable-frequency electric stimulus signal is conducted to the diaphram of monitored target and/or genioglossus, namely give by this chronic variable-frequency electric stimulus signal the variable-frequency electric that the diaphram of the monitored target of suffering from copd and/or OSAHS and/or genioglossus continue to stimulate, thus promote that diaphram/genioglossus muscle fiber types transforms, also enhance its contractility and anti-fatigue ability, or when monitored target is in sleep state, the breath state of monitored target is monitored by Real-Time Monitoring module, and when its breath state is abnormal, start acute electrical stimulation pattern by electricity irritation generation module and produce acute electrical stimulation signal, conducted to its diaphram and/genioglossus by non-built-in mode percutaneous electrode again, namely the instant pace-making of diaphram of the monitored target of suffering from copd and/or OSAHS is given by acute electrical stimulation signal, and/or give genioglossus acute electricity irritation, make monitored target can recover immediately to breathe, avoid abnormal conditions such as suffocating, that is to say that this noinvasive transcutaneous electrostimulation multifunction medical instrument of the present utility model can not only give the variable-frequency electric stimulation of the diaphram persistence of monitored target or instant pace-making, the variable-frequency electric that also can give the genioglossus persistence of monitored target stimulates or acute electricity irritation, can also give diaphram and the genioglossus chronic variable-frequency electric stimulation therapy/acute electronic stimulation of monitored target, namely this noinvasive transcutaneous electrostimulation multifunction medical instrument of the present utility model combines the function of diaphragmatic fatigue and OSAHS electronic stimulation simultaneously, and noinvasive transcutaneous electrostimulation multifunction medical instrument of the present utility model is by while the acute electricity irritation of monitored target genioglossus of suffering from OSAHS, the variable-frequency electric also giving its diaphram persistence stimulates, make to play assistant reinforcement open airway, strengthen the therapeutic effect of OSAHS, the i.e. acute diaphragm pacing of noinvasive transcutaneous electrostimulation multifunction medical instrument collection of the present utility model and the electricity irritation of chronic frequency conversion diaphram and acute genioglossus electricity irritation, frequency conversion genioglossus electricity irritation etc. are multi-functional to be integrated, both apnea was stopped by acute electronic stimulation, reverse anoxia, contractility and the anti-fatigue ability of diaphram and genioglossus is improved again by variable-frequency electric stimulation therapy, there is treatment, prevention double effects.
Accompanying drawing explanation
Below in conjunction with drawings and Examples, the invention will be further described.
Fig. 1 is the functional block diagram of an embodiment of a kind of noinvasive transcutaneous electrostimulation instrument of the present invention.
Detailed description of the invention
Below with reference to accompanying drawing, the present invention is described in detail.
Because COPD and OSAHS can be passed through electricity irritation related breathing flesh to reach the effect for the treatment of, such as COPD is by its diaphram of electricity irritation, OSAHS is by its genioglossus of electricity irritation, and EDP even can also play assistant reinforcement open airway, strengthen the therapeutic effect of OSAHS, therefore, by the electronic stimulation mode of the electronic stimulation mode of diaphragmatic fatigue in conjunction with OSAHS, thus obtain noinvasive transcutaneous electrostimulation instrument of the present invention.Below in conjunction with accompanying drawing 1 and specific embodiment, this noinvasive transcutaneous electrostimulation instrument of the present invention is described in detail.
See Fig. 1, for the functional block diagram of an embodiment of a kind of noinvasive transcutaneous electrostimulation instrument of the present invention, during concrete enforcement, this noinvasive transcutaneous electrostimulation instrument 1 of the present embodiment comprises Real-Time Monitoring module 11, electrical stimulation signal generation module 12, and some non-built-in mode percutaneous electrodes 13, wherein, Real-Time Monitoring module 11, breath state when being in sleep state for Real-Time Monitoring monitored target, obtain the sleep parameters of this monitored target, and export electrical stimulation signal generation module 12 to, this electrical stimulation signal generation module 12, for providing at least two kinds of electrical stimulation pattern, these at least two kinds of electrical stimulation pattern comprise chronic variable-frequency electric stimulus modelity and acute electrical stimulation pattern, and when monitored target is not in sleep state, start chronic variable-frequency electric stimulus modelity and produce chronic variable-frequency electric stimulus signal, and export non-built-in mode percutaneous electrode 13 to, or when monitored target is in sleep state, judge whether the breath state of this monitored target is normal according to the sleep parameters analysis that above-mentioned Real-Time Monitoring module 11 Real-Time Monitoring obtains, if abnormal, start acute electrical stimulation pattern and produce acute electrical stimulation signal, and export non-built-in mode percutaneous electrode 13 to, this non-built-in mode percutaneous electrode 13, chronic variable-frequency electric stimulus signal for this electrical stimulation signal generation module 12 being produced conducts to the diaphram of monitored target and/or genioglossus, or conducts the acute electrical stimulation signal that this electrical stimulation signal generation module 12 produces to the diaphram of monitored target and/or genioglossus.During concrete enforcement, in the present embodiment, this chronic variable-frequency electric stimulus signal adopts the train of pulse of the 2.5Hz/10Hz compound physiologic frequency 40Hz of persistence.
See Fig. 1, in the present embodiment, this Real-Time Monitoring module 11 comprises heat-sensitive type mouth and nose pneumatic sensor 111, for monitoring nostril when monitored target is in sleep state and oral cavity respiratory air flow, obtains oral cavity, the nostril breath signal of monitored target; Breast abdominal respiration sensor 112, for monitoring breast abdomen motion when monitored target is in sleep state, obtains the breast abdominal respiration signal of monitored target; And transcutaneous oxygen saturation sensor 113, for monitoring blood oxygen saturation when monitored target is in sleep state; The breath signal (comprising oral cavity, nostril breath signal and breast abdominal respiration signal) that in the present embodiment, this Real-Time Monitoring module 11 monitors and blood oxygen concentration parameter are sleep parameters.Only have when monitored target is in sleep state in the present embodiment, the breath state of this Real-Time Monitoring module 11 these monitored targets of Real-Time Monitoring, thus obtain sleep parameters.In the present embodiment, Real-Time Monitoring comprises Real-Time Monitoring and is in the initial breath state of dormant monitored target, also comprise Real-Time Monitoring monitored target be in acute electrical stimulation pattern under breath state.
In the present embodiment, the sleep-respiratory situation of this monitored target comprises abnormal and normal; Wherein extremely refer to that monitored target is when sleep state, it is breathed and occurs asphyxia or be tending towards suspending, or its blood oxygen concentration is lower than normal value.
See Fig. 1, in the present embodiment, this some non-built-in mode percutaneous electrode 13 comprises diaphragm pacing electrode 131, for receiving the chronic variable-frequency electric stimulus signal or acute electrical stimulation signal that above-mentioned electrical stimulation signal generation module 122 produces, and is conducted to the diaphram of monitored target; Genioglossus electrode 132, for receiving the chronic variable-frequency electric stimulus signal or acute electrical stimulation signal that above-mentioned electrical stimulation signal generation module 122 produces, and is conducted to the genioglossus of monitored target.
See Fig. 1, in the present embodiment, this electrical stimulation signal generation module 12 specifically comprises memorizer 123, programmable microprocessor 121 and electrical stimulation signal generator 122, this electrical stimulation signal generator 122 comprises some first output channels and some second output channels, this the first output channel genioglossus electrode 132 is electrically connected, and the second output channel is connected with diaphragm pacing electrode electricity, wherein, memorizer 123 is for storing the chronic variable-frequency electric stimulus signal parameter preset by monitored target or medical worker, and this chronic variable-frequency electric stimulus signal parameter comprises the gating parameter of the first output channel and/or the second output channel described in gating, programmable microprocessor 121 is for providing at least two kinds of electrical stimulation pattern, and when monitored target is not in sleep state, obtain the chronic variable-frequency electric stimulus signal parameter preset and trigger the chronic variable-frequency electric stimulus signal producing correspondence with electrical stimulation signal generator 122, or when this monitored target is in sleep state, judge that whether the breath state of this monitored target is normal according to the sleep parameters analysis that Real-Time Monitoring module 11 Real-Time Monitoring obtains, if abnormal, produce corresponding acute electrical stimulation signal parameter according to the sleep parameters that Real-Time Monitoring obtains, and trigger according to this acute electrical stimulation signal parameter the acute electrical stimulation signal that this electrical stimulation signal generator 122 produces correspondence, this acute electrical stimulation signal parameter comprises the gating parameter of this first output channel of gating and/or the second output channel, this electrical stimulation signal generator 122 is then for producing corresponding chronic variable-frequency electric stimulus signal according to the chronic variable-frequency electric stimulus signal parameter preset, and the first output channel in this chronic variable-frequency electric stimulus signal parameter of gating corresponding to gating parameter and/or the second output channel, this chronic variable-frequency electric stimulus signal is exported to corresponding genioglossus electrode 132 and/or diaphragm pacing electrode 131 again by described first output channel and/or the second output channel, or produce corresponding acute electrical stimulation signal according to the acute electrical stimulation signal parameter that this programmable microprocessor 121 produces, and the first output channel of gating parameter institute gating and/or the second output channel in this acute electrical stimulation signal parameter of gating, this acute electrical stimulation signal is exported to genioglossus electrode 132 and/or diaphragm pacing electrode 131 again by this first output channel and/or the second output channel.In the present embodiment, this memorizer 123 and programmable microprocessor 121 integrate, the form of single-chip microcomputer can be adopted realize, namely single-chip microcomputer is adopted to control electrical stimulation pattern, intelligence degree is high, all parameters all achieve total digitalization and regulate, and show by the display module of single-chip microcomputer.Simultaneously owing to adopting powerful single-chip microcomputer to be control core, decrease peripheral circuit, therefore substantially increase reliability, reduce volume, regulated by totally digitilized panel, very easy to use.Certainly also accessible site is together for this electrical stimulation signal generator 123.
In one embodiment, this programmable microprocessor 121 specifically comprises judging unit, and the sleep parameters for obtaining according to Real-Time Monitoring module 11 judges that whether the breath state of monitored target is normal, obtains judged result; Trigger element, for when the judged result of this judging unit be breath state abnormal time, produce corresponding acute electrical stimulation signal parameter according to this sleep parameters, and produce corresponding acute electrical stimulation signal according to this acute electrical stimulation signal parameter triggering electrical stimulation signal generator 122; Or when starting chronic variable-frequency electric stimulus modelity, obtaining the chronic variable-frequency electric stimulus signal parameter preset and producing corresponding chronic variable-frequency electric stimulus signal to trigger electrical stimulation signal generator 122.This memorizer then comprises program storage unit (PSU) and data storage cell, this program storage unit (PSU) is then for storing in whole processing procedure each program needing to call, and data storage cell is then for storing the chronic variable-frequency electric stimulus signal parameter that monitored target or medical worker preset; This memorizer also can comprise non-volatile memory cells, for storing the acute electrical stimulation signal parameter that programmable microprocessor 121 produces according to the sleep parameters that Real-Time Monitoring obtains, and the sleep parameters of monitored target under the acute electrical stimulation signal produced according to this acute electrical stimulation signal parameter.The present embodiment, by the various parameters in memorizer store electricity stimulating course, makes it have automatic Memory function, thus the parameter arranged when last time is started shooting can automatically perform when next time starts shooting, and uses convenient.And because the handling procedure etc. stored in this memorizer can be revised at any time, thus electrical stimulation signal parameter such as pacing parameter and impulse waveform just can be increased or adjustment according to the requirement of doctor, hardware need not be changed and just can realize product up-gradation.In the present embodiment, when this programmable microprocessor 121 is also for judging that when the sleep parameters obtained according to Real-Time Monitoring monitored target breath state reverts to normal, then control acute electrical stimulation pattern to close, namely export control signal control electrical stimulation signal generator 122 to close, then electrical stimulation signal generator 122 no longer produces acute electrical stimulation signal.
Some diaphragm pacing electrodes and some genioglossus electrodes 132 is provided with in the present embodiment, electrical stimulation signal generator 122 also comprises some first output channels and some second output channels, and this diaphragm pacing electrode 131 corresponds to the second output channel, genioglossus electrode 132 corresponds to the first output channel.And due to the one in monitored target possibility suffering from copd and OSAHS, possibility two kinds all suffers from.If monitored target only suffers from COPD, then only need give its diaphram electricity irritation, therefore, need gating second output channel; If monitored target only suffers from OSAHS, then only need give its genioglossus electricity irritation, therefore, need gating first output channel; If monitored target is suffering from copd and OSAHS simultaneously, then need gating first output channel and the second output channel simultaneously, namely for the output channel that different diseases and different electrical stimulation pattern need gating different.Therefore, the present embodiment, by arranging corresponding gating parameter in chronic variable-frequency electric stimulus signal parameter and acute electrical stimulation signal parameter, makes this electrical stimulation signal generator 122 can carry out the corresponding output channel of gating according to this gating parameter.Such as when needs give diaphram electricity irritation, then the second output channel of being connected with diaphragm pacing electrode 131 according to the gating parameter gating in this chronic variable-frequency electric stimulus signal parameter/acute electrical stimulation signal parameter of electrical stimulation signal generator 122, and by this second output channel, chronic variable-frequency electric stimulus signal/acute electrical stimulation signal is exported to this diaphragm pacing electrode 131.In like manner, when needs give genioglossus electricity irritation, then according to the first output channel that the gating parameter gating in chronic variable-frequency electric stimulus signal parameter/acute electrical stimulation signal parameter is connected with genioglossus electrode 132; When needing to give genioglossus and diaphram electricity irritation simultaneously, then distinguish the second output channel that gating is connected with diaphragm pacing electrode 131, and the first output channel be connected with genioglossus electrode 132.In the present embodiment, this chronic variable-frequency electric stimulus signal parameter and acute electrical stimulation signal parameter also comprise the intensity of this electrical stimulation signal under associative mode, direction, time span and cycle.
For the monitored target suffering from OSAHS, EDP also can play assistant reinforcement open airway, strengthen the therapeutic effect of OSAHS, namely when Real-Time Monitoring module 11 monitor its breath state abnormal time, carrying out outside acute electronic stimulation to its genioglossus, also can carry out chronic variable-frequency electric stimulation to its diaphram simultaneously, thus recover the therapeutic effect playing assistant reinforcement open airway, enhancing OSAHS while monitored target is breathed.
Therefore, in another specific embodiment, when monitored target is in sleep state, and when judging that the breath state of this monitored target is abnormal according to sleep parameters analysis, chronic variable-frequency electric stimulus modelity also can be started while this electrical stimulation signal generation module 12 starts acute electrical stimulation signal pattern, namely programmable microprocessor 121 is for producing acute electrical stimulation signal parameter with while triggering electrical stimulation signal generator 122 and producing acute electrical stimulation signal according to this sleep parameters, also can obtain default chronic variable-frequency electric stimulus signal parameter and produce chronic variable-frequency electric stimulus signal to trigger this electrical stimulation signal generator 122, electrical stimulation signal generator 122 is then for producing corresponding acute electrical stimulation signal according to this acute electrical stimulation signal parameter, and according to the first output channel that gating parameter gating in this acute electrical stimulation signal parameter is connected with genioglossus electrode, acute electrical stimulation signal is exported to genioglossus electrode 132 again by this first output channel, finally by this genioglossus electrode 13, this acute electrical stimulation signal is conducted to the genioglossus of monitored target, electrical stimulation signal generator 122 is also for producing chronic variable-frequency electric stimulus signal according to above-mentioned chronic variable-frequency electric stimulus signal parameter simultaneously, and according to the second output channel that gating parameter gating in this chronic variable-frequency electric stimulus signal parameter is connected with diaphragm pacing electrode 131, and export chronic variable-frequency electric stimulus signal to diaphragm pacing electrode 131 by this second output channel, by this diaphragm pacing electrode 131, this chronic variable-frequency electric stimulus signal is conducted to the diaphram of monitored target again.By giving monitored target genioglossus acute electricity irritation simultaneously in the present embodiment, and give the lasting variable-frequency electric stimulation of monitored target diaphram, make can not only recover to breathe, play assistant reinforcement open airway simultaneously, strengthen the therapeutic effect of OSAHS.
The noinvasive transcutaneous electrostimulation instrument of the present embodiment by electrical stimulation signal generation module 12 when monitored target is not in sleep state, start chronic variable-frequency electric stimulus modelity and produce chronic variable-frequency electric stimulus signal, and by non-built-in mode percutaneous electrode 13, this chronic variable-frequency electric stimulus signal is conducted to the diaphram of monitored target or genioglossus, namely the diaphram of the monitored target of suffering from copd and/or OSAHS and/or the electricity irritation of the successional 2.5Hz/10Hz compound 40Hz of genioglossus is given, its muscle fiber is made to have suitable reconstruct, contractility and anti-fatigue ability are improved, thus prevent epithelium healing subside and narrow, or when monitored target is in sleep state, the breath state of monitored target is monitored by Real-Time Monitoring module 11, and when its breath state is abnormal, start acute electrical stimulation pattern by electrical stimulation signal generation module 12 and produce acute electrical stimulation signal, conducted to its diaphram and/genioglossus by non-built-in mode percutaneous electrode 13 again, namely the diaphram of the monitored target of suffering from copd and/or OSAHS is given and/or the suitable electrical stimulation signal of genioglossus carries out electronic stimulation, thus the variable-frequency electric that the diaphram making this noinvasive transcutaneous electrostimulation instrument of the present invention can not only give monitored target continues stimulates/instant pace-making, variable-frequency electric stimulation/acute the electricity irritation that the genioglossus that also can give monitored target continues, variable-frequency electric stimulation/acute the electricity irritation that the diaphram of monitored target and genioglossus continue can also be given simultaneously, namely this noinvasive transcutaneous electrostimulation instrument of the present invention combines the function of diaphragmatic fatigue and OSAHS electronic stimulation.On the other hand, this noinvasive transcutaneous electrostimulation instrument of the present embodiment also produces while acute electrical stimulation signal carries out acute electronic stimulation to the monitored target suffering from OSAHS by electrical stimulation signal generation module 12 according to sleep parameters, also produce chronic variable-frequency electric stimulus signal by electrical stimulation signal generation module 12 according to default chronic variable-frequency electric stimulus signal parameter, thus also give its diaphram while suffering from the acute electricity irritation of this monitored target genioglossus of OSAHS with the variable-frequency electric continued stimulation, thus in termination asphyxia, the double effects of prevention and therapy is reached while recovering to breathe.
To sum up, it is multi-functional that the noinvasive transcutaneous electrostimulation multifunction medical instrument of the present embodiment integrates acute diaphragm pacing and the electricity irritation of chronic frequency conversion diaphram and acute genioglossus electricity irritation, the electricity irritation of frequency conversion genioglossus etc., both stopped apnea by acute electronic stimulation, reversed anoxia, improve again contractility and the anti-fatigue ability of diaphram and genioglossus by variable-frequency electric stimulation therapy, have and have treatment, prevention double effects.Below in conjunction with operation principle and specific embodiment, this noinvasive transcutaneous electrostimulation instrument to the present embodiment is described in detail.
When monitored target is not in sleep state, then electricity irritation generation module 12 starts chronic variable-frequency electric stimulus modelity and produces chronic variable-frequency electric stimulus signal, namely the chronic variable-frequency electric stimulus signal parameter that the monitored target of storage or medical worker are preset by programmable microprocessor 121 sends to electrical stimulation signal generator 122 to produce chronic variable-frequency electric stimulus signal to trigger it, the chronic variable-frequency electric stimulus signal parameter that then electrical stimulation signal generator 122 is preset according to this produces corresponding chronic variable-frequency electric stimulus signal, and the output channel corresponding according to the gating parameter gating in this chronic variable-frequency electric stimulus signal parameter exports the chronic variable-frequency electric stimulus signal produced to corresponding diaphragm pacing electrode 131 and/or genioglossus electrode 132, by diaphragm pacing electrode 131 and/or genioglossus electrode 132, this chronic variable-frequency electric stimulus signal is conducted to the diaphram of monitored target and/or genioglossus again.Such as, when the monitored target of suffering from copd is not in sleep state, the chronic variable-frequency electric stimulus signal parameter that then monitored target or medical worker are preset by programmable microprocessor 121 sends to electrical stimulation signal generator 122 to produce chronic variable-frequency electric stimulus signal to trigger it, this chronic variable-frequency electric stimulus signal parameter comprises the intensity of this chronic variable-frequency electric stimulus signal, direction, time span and cycle, and the gating parameter of the second output channel that gating electrical stimulation signal generator 122 is connected with diaphragm pacing electrode 131; 122, electrical stimulation signal generator produces corresponding chronic variable-frequency electric stimulus signal according to this chronic variable-frequency electric stimulus signal parameter, and gating second output channel, then export this chronic variable-frequency electric stimulus signal to this diaphragm pacing electrode 131; The chronic variable-frequency electric stimulus signal that this electrical stimulation signal generator 122 exports by 131, diaphragm pacing electrode conducts to the diaphram of monitored target.And when the monitored target suffering from SOAHS is not in sleep state, its principle is identical with above-mentioned principle, unlike, after electrical stimulation signal generator 122 produces chronic variable-frequency electric stimulus signal, it exports this chronic variable-frequency electric stimulus signal to genioglossus electrode 132 by the first output channel, and is conducted this chronic variable-frequency electric stimulus signal to the genioglossus of monitored target by this genioglossus electrode 132.If when monitored target suffers from this COPD and OSAHS simultaneously, after then this electrical stimulation signal generator 122 produces chronic variable-frequency electric stimulus signal, simultaneously the second output channel of being connected with diaphragm pacing electrode 131 of gating, and the first output channel to be connected with genioglossus electrode 132, and export this chronic variable-frequency electric stimulus signal to diaphragm pacing electrode 131 and genioglossus 132 respectively by these two passages, then conducted respectively by this diaphragm pacing electrode 131 and genioglossus electrode 132 and carry out electronic stimulation to the diaphram of monitored target and genioglossus.
When monitored target is in sleep state, then according to the sleep parameters analysis that Real-Time Monitoring module 11 Real-Time Monitoring obtains, programmable microprocessor 121 judges that whether this monitored target breath state is normal, if abnormal, start acute electrical stimulation pattern, namely the sleep parameters that programmable microprocessor 121 obtains according to this Real-Time Monitoring produces corresponding acute electrical stimulation signal parameter, this acute electrical stimulation signal parameter comprises the intensity of this acute electrical stimulation signal under acute electrical stimulation pattern, direction, time span and cycle, and the gating parameter of gating electrical stimulation signal generator 122 first output channel and/or the second output channel, 122, electrical stimulation signal generator produces corresponding acute electrical stimulation signal according to this acute electrical stimulation signal parameter, and the output channel corresponding according to above-mentioned gating parameter gating, this the acute electrical stimulation signal produced is exported to corresponding diaphragm pacing electrode 131 and/or genioglossus electrode 132 again by the output channel of gating, finally, by diaphragm pacing electrode 131 and/or genioglossus electrode 132, this acute electrical stimulation signal is conducted to the diaphram of monitored target and/or genioglossus, and when the sleep parameters obtained according to Real-Time Monitoring judges that monitored target carries out recovering normal after electronic stimulation through acute electrical stimulation signal, then programmable microprocessor 121 controls the closedown of acute electrical stimulation pattern, does not namely produce acute electrical stimulation signal parameter triggering electrical stimulation signal generator 122 and produces acute electrical stimulation signal.Such as, when the monitored target of suffering from copd is in sleep state, according to the sleep parameters analysis that Real-Time Monitoring module 11 Real-Time Monitoring obtains, programmable microprocessor 121 judges that whether the breath state of this monitored target is normal, if abnormal, produce acute electrical stimulation signal parameter according to this sleep parameters, this acute parameters of electrical stimulation comprises the intensity of this acute electrical stimulation signal under acute electrical stimulation pattern, direction, time span and cycle, and the gating parameter of the first output channel be connected with diaphragm pacing electrode 131 in gating electrical stimulation signal generator 122; 122, electrical stimulation signal generator produces corresponding acute electrical stimulation signal according to this acute electrical stimulation signal parameter, and according to the first output channel that this gating parameter gating is connected with diaphragm pacing electrode 131, then export this acute electrical stimulation signal produced to this diaphragm pacing electrode 131 by this first output channel; This acute electrical stimulation signal conducts to the diaphram of monitored target by 131, diaphragm pacing electrode.And when after electronic stimulation, when the sleep parameters again obtained according to Real-Time Monitoring judges that monitored target breath state reverts to normal, then control to close acute electrical stimulation pattern.When the monitored target suffering from SOAHS is in sleep state, its principle is identical with above-mentioned principle, unlike, after electrical stimulation signal generator 122 produces acute electrical stimulation signal, it exports this acute electrical stimulation signal to genioglossus electrode 132 by the second output channel be connected with genioglossus electrode 132, and is conducted this acute electrical stimulation signal to the genioglossus of monitored target by this genioglossus electrode 132.And when monitored target while when suffering from copd and OSAHS, then the acute electrical stimulation signal produced can be exported to diaphragm pacing electrode 131 and genioglossus electrode 132 respectively by the second output channel and the first output channel by this electrical stimulation signal generator 122, carries out electronic stimulation by this diaphragm pacing electrode 131 and genioglossus electrode 132 to the diaphram of monitored target and genioglossus simultaneously.
In another specific embodiment, when the monitored target suffering from SOAHS is in sleep state, and its breath state abnormal time, also chronic variable-frequency electric stimulus modelity can be started while this electrical stimulation signal generation module 12 starts acute electrical stimulation pattern, namely electrical stimulation signal generator 122 is producing while acute electrical stimulation signal parameter produces acute electrical stimulation signal according to programmable microprocessor 121, also can produce chronic variable-frequency electric stimulus signal according to the chronic variable-frequency electric stimulus signal parameter preset, and according to the gating parameter in the gating parameter in this acute electrical stimulation signal parameter and chronic variable-frequency electric stimulus signal parameter, the second output channel that difference gating is connected with genioglossus electrode 132 and the first output channel be connected with diaphragm pacing electrode 131, and export this acute electrical stimulation signal to genioglossus electrode 132 respectively by this first output channel, and export this chronic variable-frequency electric stimulus signal to diaphram electrode 131 by this second output channel, by this genioglossus electrode 132 acute electrical stimulation signal conducted again and carry out electronic stimulation to the genioglossus of monitored target, and by this electrode 131 this chronic variable-frequency electric stimulus signal conducted and carry out electronic stimulation to the diaphram of monitored target.And when after electronic stimulation, when the sleep parameters again obtained according to Real-Time Monitoring judges that monitored target breath state reverts to normal, then control to close acute electrical stimulation pattern and chronic variable-frequency electric stimulus modelity.
If monitored target is suffering from copd and OSAHS simultaneously, and monitor it when being in adnormal respiration, the acute electrical stimulation pattern in aforesaid way can be adopted, namely acute electrical stimulation signal is adopted to carry out electronic stimulation to diaphram and genioglossus respectively, also the acute electrical stimulation pattern in aforesaid way can be adopted in conjunction with chronic variable-frequency electric stimulus modelity, namely, while adopting acute electrical stimulation signal to carry out electronic stimulation to genioglossus, chronic variable-frequency electric stimulation mode is adopted to carry out electronic stimulation to its diaphram.
What finally illustrate is, above embodiment is only in order to illustrate technical scheme of the present invention and unrestricted, although be described in detail this patent with reference to preferred embodiment, those of ordinary skill in the art is to be understood that, can modify to technical scheme of the present invention or equivalent replacement, and not departing from aim and the scope of technical solution of the present invention, it all should be encompassed in the middle of right of the present invention.
Claims (8)
1. noinvasive percutaneous variable-frequency electric stimulates a multifunctional breath therapeutic instrument, it is characterized in that, comprising:
Real-Time Monitoring module (11), breath state when being in sleep state for Real-Time Monitoring monitored target, gets sleep parameters;
Electrical stimulation signal generation module (12), for providing at least two kinds of electrical stimulation pattern, and when described monitored target is in non-sleep state, start chronic variable-frequency electric stimulus modelity and produce chronic variable-frequency electric stimulus signal, and the diaphragm pacing electrode (131) be sent in some non-built-in mode percutaneous electrodes (13) or genioglossus electrode (132), or the diaphragm pacing electrode (131) be simultaneously sent in described some non-built-in mode percutaneous electrodes (13) and genioglossus motor (132), or when described monitored target is in sleep state, judge that whether the breath state of described monitored target is abnormal according to the described sleep parameters analysis that Real-Time Monitoring obtains, if abnormal, then start acute electrical stimulation pattern and produce acute electrical stimulation signal, and the diaphragm pacing electrode (131) be sent in some non-built-in mode percutaneous electrodes (13) or genioglossus electrode (132), or the diaphragm pacing electrode (131) be simultaneously sent in some non-built-in mode percutaneous electrodes (13) and genioglossus electrode (132), or when described monitored target is in sleep state, judge that whether the breath state of described monitored target is abnormal according to the described sleep parameters analysis that Real-Time Monitoring obtains, if abnormal, then start acute electrical stimulation pattern to produce acute electrical stimulation signal and be sent to described genioglossus electrode (132), simultaneously, start chronic variable-frequency electric stimulus modelity to produce chronic variable-frequency electric stimulus signal and be sent to described diaphram electrode (131),
Some non-built-in mode percutaneous electrodes (13), for conducting to the diaphram of described monitored target and/or genioglossus by described chronic variable-frequency electric stimulus signal; Or conduct to the diaphram of described monitored target and/or genioglossus by described acute electrical stimulation signal, described non-built-in mode percutaneous electrode (13) comprising:
Diaphragm pacing electrode (131), for receiving the chronic variable-frequency electric stimulus signal or acute electrical stimulation signal that described electrical stimulation signal generation module (12) produces, and conduction is to the diaphram of described monitored target;
Genioglossus electrode (132), for receiving the chronic variable-frequency electric stimulus signal or acute electrical stimulation signal that described electrical stimulation signal generation module (12) produces, and conduction is to the genioglossus of described monitored target.
2. noinvasive percutaneous variable-frequency electric as claimed in claim 1 stimulates multifunctional breath therapeutic instrument, it is characterized in that, when the monitored target suffering from OSAHS is in sleep state, and when judging according to the described sleep parameters that Real-Time Monitoring obtains the described monitored target breath state exception suffering from OSAHS
Described electrical stimulation signal generation module (12) produces acute electrical stimulation signal for starting acute electrical stimulation pattern, and exports described genioglossus electrode (132) and described diaphragm pacing electrode (131) to;
Described genioglossus electrode (132) is for conducting to the genioglossus of described monitored target by described acute electrical stimulation signal; Simultaneously
Described diaphragm pacing electrode (131) is for conducting described acute electrical stimulation signal to the diaphram of described monitored target.
3. noinvasive percutaneous variable-frequency electric as claimed in claim 2 stimulates multifunctional breath therapeutic instrument, it is characterized in that, described electricity irritation generation module (12) also for when the breath state of the described monitored target judged under acute electrical stimulation pattern according to described sleep parameters reverts to normal, closes described acute electrical stimulation pattern.
4. noinvasive percutaneous variable-frequency electric as claimed in claim 2 stimulates multifunctional breath therapeutic instrument, it is characterized in that, described electrical stimulation signal generation module (12) comprises memorizer, programmable microprocessor (121) and electrical stimulation signal generator (122), described electrical stimulation signal generator (122) comprises first and second output channels some, described first output channel is electrically connected with described genioglossus electrode, described second output channel is electrically connected with described diaphragm pacing electrode, wherein
Described memorizer is for storing default chronic variable-frequency electric stimulus signal parameter; Described chronic variable-frequency electric stimulus signal parameter comprises the gating parameter corresponding to described first output channel and/or the second output channel;
Described programmable microprocessor (121), for providing at least two kinds of electrical stimulation pattern, and when described monitored target is in non-sleep state, obtains the chronic variable-frequency electric stimulus signal parameter preset and produce corresponding chronic variable-frequency electric stimulus signal to trigger described electrical stimulation signal generator; Or when described monitored target is in sleep state, judge that whether the breath state of described monitored target is abnormal according to the described sleep parameters analysis that Real-Time Monitoring obtains, if abnormal, then the described sleep parameters obtained according to Real-Time Monitoring generates acute electrical stimulation signal parameter and produces corresponding acute electrical stimulation signal to trigger described electrical stimulation signal generator; Described acute electrical stimulation signal parameter comprises the gating parameter corresponding to described first output channel and/or the second output channel;
Described electrical stimulation signal generator (122), chronic variable-frequency electric stimulus signal parameter for presetting according to this produces corresponding chronic variable-frequency electric stimulus signal, and the first output channel in chronic variable-frequency electric stimulus parameter described in gating corresponding to gating parameter and/or the second output channel, then export described chronic variable-frequency electric stimulus signal to corresponding genioglossus electrode (132) and/or diaphragm pacing electrode (131) by described first output channel and/or the second output channel; Or produce corresponding acute electrical stimulation signal according to described acute electrical stimulation signal parameter, and the first output channel in acute electrical stimulation signal parameter described in gating corresponding to gating parameter and/or the second output channel, then export described acute electrical stimulation signal to corresponding genioglossus electrode (132) and/or diaphragm pacing electrode (131) by described first output channel and/or the second output channel.
5. noinvasive percutaneous variable-frequency electric as claimed in claim 4 stimulates multifunctional breath therapeutic instrument, it is characterized in that, when the monitored target suffering from OSAHS is in sleep state, and when judging according to the described sleep parameters analysis that Real-Time Monitoring obtains the breath state exception suffering from the described monitored target of OSAHS
Described programmable microprocessor (121) produces corresponding acute electrical stimulation signal for producing corresponding acute electrical stimulation signal parameter at the described sleep parameters obtained according to Real-Time Monitoring to trigger described electrical stimulation signal generator (122); Gating parameter in described acute electrical stimulation signal parameter corresponds to the first output channel and second output channel of described electrical stimulation signal generator;
Described electrical stimulation signal generator (122) produces corresponding acute electrical stimulation signal according to described acute electrical stimulation signal parameter, and the first output channel in acute electrical stimulation signal parameter described in gating corresponding to gating parameter and the second output channel, described acute electrical stimulation signal is exported to described genioglossus electrode (131) again by described first output channel, meanwhile, described acute electrical stimulation signal is exported to diaphragm pacing electrode (132) by described second output channel.
6. noinvasive percutaneous variable-frequency electric as claimed in claim 5 stimulates multifunctional breath therapeutic instrument, and it is characterized in that, described programmable microprocessor comprises:
Judging unit, the sleep parameters for obtaining according to described Real-Time Monitoring module (11) Real-Time Monitoring judges that whether the breath state of described monitored target is abnormal, obtains judged result;
Trigger element, during for being breath state exception when the judged result of described judging unit, producing acute electrical stimulation signal parameter according to described sleep parameters and producing corresponding acute electrical stimulation signal to trigger described electrical stimulation signal generator (122); And/or when starting chronic variable-frequency electric stimulus modelity, obtaining described default chronic variable-frequency electric stimulus signal parameter and triggering described electrical stimulation signal generator (122) and produce corresponding chronic variable-frequency electric stimulus signal.
7. noinvasive percutaneous variable-frequency electric as claimed in claim 5 stimulates multifunctional breath therapeutic instrument, it is characterized in that, described memorizer is also for storing described acute electrical stimulation signal parameter, and Real-Time Monitoring obtains, according to the sleep parameters of monitored target under the acute electrical stimulation signal that described acute electrical stimulation signal parameter produces.
8. noinvasive percutaneous variable-frequency electric stimulates multifunctional breath therapeutic instrument as claimed in any of claims 1 to 7 in one of claims, and it is characterized in that, described Real-Time Monitoring module (11) comprising:
Heat-sensitive type mouth and nose pneumatic sensor (111), for monitoring mouth and nose respiratory air flow when monitored target is in sleep state, obtaining the mouth and nose breath signal of monitored target, and exporting described electrical stimulation signal generation module (12) to;
Breast abdominal respiration sensor (112), for monitoring breast abdomen motion when monitored target is in sleep state, obtaining the breast abdominal respiration signal of monitored target, and exporting described electrical stimulation signal generation module (12) to;
Transcutaneous oxygen saturation sensor (113), for monitoring transcutaneous oxygen saturation when monitored target is in sleep state, and exports described electrical stimulation signal generation module (12) to.
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| CN104887234B (en) * | 2015-05-19 | 2018-02-09 | 中山大学 | The continuous airway obstruction appraisal procedure and device of a kind of low physiological stress |
| WO2018119071A1 (en) * | 2016-12-22 | 2018-06-28 | Aerin Medical, Inc. | Soft palate treatment |
| US11806071B2 (en) | 2016-12-22 | 2023-11-07 | Aerin Medical Inc. | Soft palate treatment |
| CN107789714A (en) * | 2017-10-26 | 2018-03-13 | 山东大学齐鲁医院 | A kind of multi-functional exhaled positive pressure nasal mask |
| CN110193139A (en) * | 2019-06-27 | 2019-09-03 | 北京雅果科技有限公司 | A kind of device and method for respiratory muscle electric stimulation |
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| CN2621723Y (en) * | 2003-04-03 | 2004-06-30 | 温州医学院 | Non-invasive percutaneous electrical stimulator for treating obstructive sleep apnea syndrome |
| CN203208538U (en) * | 2012-12-31 | 2013-09-25 | 中国人民解放军第三军医大学第一附属医院 | Noninvasive transcutaneous variable-frequency electrical simulation multifunctional respiratory treatment instrument |
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| AU2010318651A1 (en) * | 2009-11-10 | 2012-05-03 | Imthera Medical, Inc. | System for stimulating a hypoglossal nerve for controlling the position of a patient's tongue |
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| CN2621723Y (en) * | 2003-04-03 | 2004-06-30 | 温州医学院 | Non-invasive percutaneous electrical stimulator for treating obstructive sleep apnea syndrome |
| CN203208538U (en) * | 2012-12-31 | 2013-09-25 | 中国人民解放军第三军医大学第一附属医院 | Noninvasive transcutaneous variable-frequency electrical simulation multifunctional respiratory treatment instrument |
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