CN103044024B - Bone implanting prosthetic zirconia base composite ceramics and bone implanting prosthetic prepared therefrom - Google Patents
Bone implanting prosthetic zirconia base composite ceramics and bone implanting prosthetic prepared therefrom Download PDFInfo
- Publication number
- CN103044024B CN103044024B CN201210529626.2A CN201210529626A CN103044024B CN 103044024 B CN103044024 B CN 103044024B CN 201210529626 A CN201210529626 A CN 201210529626A CN 103044024 B CN103044024 B CN 103044024B
- Authority
- CN
- China
- Prior art keywords
- composite ceramics
- implanting prosthetic
- zro
- base composite
- zrc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 title claims abstract description 78
- 239000002131 composite material Substances 0.000 title claims abstract description 78
- 239000000919 ceramic Substances 0.000 title claims abstract description 69
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 34
- 239000003381 stabilizer Substances 0.000 claims abstract description 10
- 239000000843 powder Substances 0.000 claims description 10
- 239000003595 mist Substances 0.000 claims description 6
- 238000013001 point bending Methods 0.000 claims description 6
- 238000005245 sintering Methods 0.000 claims description 6
- 239000000758 substrate Substances 0.000 claims description 6
- 238000005056 compaction Methods 0.000 claims description 4
- 210000000629 knee joint Anatomy 0.000 claims description 4
- 238000011540 hip replacement Methods 0.000 claims description 3
- 210000003127 knee Anatomy 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000001694 thigh bone Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 abstract description 2
- 239000008187 granular material Substances 0.000 description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 238000005452 bending Methods 0.000 description 10
- RKTYLMNFRDHKIL-UHFFFAOYSA-N copper;5,10,15,20-tetraphenylporphyrin-22,24-diide Chemical compound [Cu+2].C1=CC(C(=C2C=CC([N-]2)=C(C=2C=CC=CC=2)C=2C=CC(N=2)=C(C=2C=CC=CC=2)C2=CC=C3[N-]2)C=2C=CC=CC=2)=NC1=C3C1=CC=CC=C1 RKTYLMNFRDHKIL-UHFFFAOYSA-N 0.000 description 10
- 239000008367 deionised water Substances 0.000 description 9
- 229910021641 deionized water Inorganic materials 0.000 description 9
- 238000002156 mixing Methods 0.000 description 8
- 239000002245 particle Substances 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 7
- 238000003825 pressing Methods 0.000 description 7
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 6
- 230000032683 aging Effects 0.000 description 6
- 239000013078 crystal Substances 0.000 description 6
- 238000002441 X-ray diffraction Methods 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- 238000000498 ball milling Methods 0.000 description 5
- 238000001816 cooling Methods 0.000 description 5
- 238000007656 fracture toughness test Methods 0.000 description 5
- 238000010335 hydrothermal treatment Methods 0.000 description 5
- 238000000465 moulding Methods 0.000 description 5
- 238000001556 precipitation Methods 0.000 description 5
- 210000004394 hip joint Anatomy 0.000 description 4
- 238000007689 inspection Methods 0.000 description 4
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 3
- 229910021529 ammonia Inorganic materials 0.000 description 3
- 238000001354 calcination Methods 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- -1 polyethylene Polymers 0.000 description 3
- 229920000573 polyethylene Polymers 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 238000001291 vacuum drying Methods 0.000 description 3
- 208000012659 Joint disease Diseases 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- VCRLKNZXFXIDSC-UHFFFAOYSA-N aluminum oxygen(2-) zirconium(4+) Chemical compound [O--].[O--].[Al+3].[Zr+4] VCRLKNZXFXIDSC-UHFFFAOYSA-N 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 238000000975 co-precipitation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000007704 wet chemistry method Methods 0.000 description 1
Abstract
The present invention relates to bone implanting prosthetic zirconia base composite ceramics and bone implanting prosthetic prepared therefrom.This zirconia base composite ceramics comprises following composition: the ZrO of 60-95mol%
2, 1-20mol% one or more stabilizing agents of ZrC and 1-12mol%, wherein said stabilizing agent is selected from by Y
2o
3, Al
2o
3, CaO, MgO and CeO
2the group formed.
Description
Technical field
The present invention relates to bone implanting prosthetic zirconia base composite ceramics, include bone implanting prosthetic prepared by this zirconia base composite ceramics further.
Background technology
Adopt artificial prosthesis to replace primary selection that impaired hip joint or knee joint have become clinical treatment hip joint disease and diseases of knee joint.At present, be used for clinically replacing impaired hip joint or kneed artificial prosthesis has metal pair polyethylene, metal to metal type and pottery to polyethylene and ceramic-on-ceramic type.Wherein, pottery obtains more and more common application to polyethylene and ceramic-on-ceramic type due to significantly reduced wear extent.The ceramic material mainly following three kinds adopted: aluminium oxide ceramics, aluminium oxide-zirconium oxide composite ceramics and zirconia ceramics.
The invention provides the new zirconia base composite ceramics being used for preparing bone implanting prosthetic.
Summary of the invention
The present invention relates to bone implanting prosthetic zirconia base composite ceramics, comprise following composition: the ZrO of 60-95mol%
2, 2-20mol% ZrC, and one or more stabilizing agents of 2-12mol%, wherein said stabilizing agent is selected from by Y
2o
3, Al
2o
3, CaO, MgO and CeO
2the group formed.
According to one embodiment of the invention, bone implanting prosthetic zirconia base composite ceramics of the present invention is become to be grouped into by following: the ZrO of 78-93mol%
2, 5-20mol% one or more stabilizing agents of ZrC and 2-12mol%, wherein said stabilizing agent is selected from by Y
2o
3, Al
2o
3, CaO, MgO and CeO
2the group formed.
According to another embodiment of the present invention, bone implanting prosthetic zirconia base composite ceramics of the present invention is become to be grouped into by following: the ZrO of 85-93mol%
2, 5-13mol% the Y of ZrC and 2-5mol%
2o
3formed.According to another embodiment of the present invention, bone implanting prosthetic zirconia base composite ceramics of the present invention is become to be grouped into by following: the ZrO of 87-91mol%
2, 7-10mol% the Y of ZrC and 2-4mol%
2o
3formed.
According to another embodiment of the present invention, bone implanting prosthetic zirconia base composite ceramics of the present invention is become to be grouped into by following: the ZrO of 78-91mol%
2, 5-20mol% the Y of ZrC, 1-3mol%
2o
3, 3-9mol% CeO
2.According to another embodiment of the present invention, bone implanting prosthetic zirconia base composite ceramics of the present invention is become to be grouped into by following: the ZrO of 78-91mol%
2, 5-10mol% the Y of ZrC, 1-3mol%
2o
3, 3-9mol% CeO
2.According to embodiment of the present invention, bone implanting prosthetic zirconia base composite ceramics of the present invention is become to be grouped into by following: the ZrO of 78-89mol%
2, 5-10mol% the Y of ZrC, 1-3mol%
2o
3, 5-9mol% CeO
2.According to embodiment of the present invention, bone implanting prosthetic zirconia base composite ceramics of the present invention is become to be grouped into by following: the ZrO of 78-85mol%
2, 7-10mol% the Y of ZrC, 1-3mol%
2o
3, 7-9mol% CeO
2.According to embodiment of the present invention, bone implanting prosthetic zirconia base composite ceramics of the present invention is become to be grouped into by following: the ZrO of 80-84mol%
2, 8-10mol% the Y of ZrC, 1-3mol%
2o
3, 7-9mol% CeO
2.
According to embodiment of the present invention, grain size≤5 micron of bone implanting prosthetic zirconia base composite ceramics of the present invention, preferably≤4 microns.
According to embodiment of the present invention, ZrC is dispersed in bone implanting prosthetic zirconia base composite ceramics of the present invention, not only increases the mechanical property of zirconia base composite ceramics, also further improves the aging resistance of zirconia base composite ceramics.
The invention further relates to the preparation method of bone implanting prosthetic zirconia base composite ceramics, comprising: 1) adopt coprecipitation or wet chemistry method to prepare ZrO
2with the composite powder of stabilizing agent, powder size is less than 100 nanometers, is preferably less than 60 nanometers; 2) by 1) in the composite powder that obtains and granularity be less than 100 nanometers, be preferably less than 50 nanometers, ZrC powder in deionized water after ball milling mixing 1-48 hour, dry; 3) by 2) in the powder that obtains suppress under uniaxial pressure under the pressure of 20-100MPa, obtain a base substrate; 4) by 3) in molded body cold isostatic compaction under 200-280MPa pressure of obtaining, obtain secondary base substrate; 5) by 4) in secondary base substrate after cold isostatic compaction put into the sintering furnace of Ar gas shielded, at 1350-1500 DEG C of sintering 1-5 hour.
The invention still further relates to the bone implanting prosthetic prepared by bone implanting prosthetic zirconia base composite ceramics.Zirconia base composite ceramics of the present invention also may be used for other industrial use.
Detailed description of the invention
Set forth the present invention particularly further by following examples, but the invention is not restricted to these embodiments.
Embodiment 1 prepares ZrO
2/ Y
2o
3composite granule
By the ZrOCl of concentration 15wt%
2.8H
2o aqueous solution and concentration are the YCl of 20wt%
3according to ZrO
2: Y
2o
3mol ratio be 1: 0.02 ratio mixing.Be heated to 65 DEG C, under constantly stirring, dropwise add ammonia to pH is 8.5, generates white colloidal precipitation.Filter out white colloidal precipitate, do not measure chloride ion with inspection in deionized water wash to filtrate.After 50 DEG C of vacuum dryings, with the ramp to 800 of 100 DEG C/h DEG C calcining 2 hours.Namely the ZrO that particle mean size is 20 nanometers is obtained
2-2mol%Y
2o
3composite granule.
Embodiment 2a preparation preparation ZrO
2/ Y
2o
3/ CeO
2composite granule
By the ZrOCl of concentration 15wt%
2.8H
2o aqueous solution, concentration are the CeCl of 15wt%
4aqueous solution and concentration are the YCl of 20wt%
3according to ZrO
2: Y
2o
3: CeO
2mol ratio be 1: 0.02: 0.04 ratio mixing.Be heated to 75 DEG C, under constantly stirring, dropwise add ammonia to pH is 8.8, generates colloidal precipitation.Filter out colloidal precipitation, do not measure chloride ion with inspection in deionized water wash to filtrate.After 50 DEG C of vacuum dryings, with the ramp to 800 of 100 DEG C/h DEG C calcining 2 hours.Namely the ZrO that particle mean size is 50 nanometers is obtained
2-2mol%Y
2o
3-4mol%CeO
2composite granule.
Embodiment 2b preparation preparation ZrO
2/ Y
2o
3/ CeO
2composite granule
By the ZrOCl of concentration 15wt%
2.8H
2o aqueous solution, concentration are the CeCl of 15wt%
4aqueous solution and concentration are the YCl of 20wt%
3according to ZrO
2: Y
2o
3: CeO
2mol ratio be 1: 0.02: 0.08 ratio mixing.Be heated to 75 DEG C, under constantly stirring, dropwise add ammonia to pH is 8.8, generates colloidal precipitation.Filter out colloidal precipitation, do not measure chloride ion with inspection in deionized water wash to filtrate.After 50 DEG C of vacuum dryings, with the ramp to 800 of 100 DEG C/h DEG C calcining 2 hours.Namely the ZrO that particle mean size is 55 nanometers is obtained
2-2mol%Y
2o
3-8mol%CeO
2composite granule.
Embodiment 3 prepares ZrO
2-Y
2o
3-ZrC composite ceramics
By ZrO prepared by embodiment 1
2/ Y
2o
3composite granule and particle mean size are that the ZrC of 30 nanometers is according to 94mol% (ZrO
2/ Y
2o
3): the ball milling mixing and carry out mist projection granulating in deionized water of the ratio of 6mol% (ZrC), obtains the granule that granularity is 60 microns.Dry-pressing formed under 50MPa pressure again, then after the quiet molding such as 250MPa is cold, then in the high temperature furnace of Ar gas shielded, be incubated 2 hours with the ramp to 1400 of 3 DEG C/minute DEG C.To obtain ZrO after the speed of 1 DEG C/minute cooling
2-Y
2o
3-ZrC composite ceramics.
The crystal structure of this composite ceramics of X-ray diffraction analysis is Tetragonal, is 0.35 μm in the grain size of this composite ceramics of sem analysis.Carry out three-point bending resistance intensity and fracture toughness test at mechanics machine, bending strength is 1180MPa, and fracture toughness is 11.8MPa.m1/2.This composite ceramics is through the pressure of 0.2MPa in water vapour 134 DEG C of hydrothermal treatment consists 5 hours, and its bending strength is 1120MPa, and toughness is 11.2MPa.m1/2, and monoclinic phase content is 4.2%, and predominate texture is still Tetragonal.There is good aging resistance.
Embodiment 4a prepares ZrO
2-Y
2o
3-CeO
2-ZrC composite ceramics
ZrO prepared by embodiment 2a
2/ Y
2o
3/ CeO
2composite granule and particle mean size are that the ZrC of 30 nanometers is according to 94mol% (ZrO
2/ Y
2o
3/ CeO
2): the ratio of 6mol% (ZrC) wet-mixed and carry out mist projection granulating in deionized water, obtains the granule that granularity is 60 microns.Dry-pressing formed under 50MPa pressure again, then after the quiet molding such as 250MPa is cold, then in the high temperature furnace of Ar gas shielded, be incubated 2 hours with the ramp to 1400 of 3 DEG C/minute DEG C.To obtain ZrO after the speed of 1 DEG C/minute cooling
2-Y
2o
3-CeO
2-ZrC composite ceramics.
The crystal structure of this composite ceramics of X-ray diffraction analysis is Tetragonal, and the grain size through this composite ceramics of sem analysis is 0.35 μm.Mechanics machine carries out three-point bending resistance intensity and fracture toughness test, and bending strength is 1200MPa, and fracture toughness is 12MPa.m1/2.
This composite ceramics is through the pressure of 0.2MPa in water vapour 134 DEG C of hydrothermal treatment consists 5 hours, and its bending strength is 1120MPa, and toughness is 11.5MPa.m1/2, and monoclinic phase content is 4%, and predominate texture is still Tetragonal.There is good aging resistance.
Embodiment 4b prepares ZrO
2-Y
2o
3-CeO
2-ZrC composite ceramics
ZrO prepared by embodiment 2a
2/ Y
2o
3/ CeO
2composite granule and particle mean size are that the ZrC of 30 nanometers is according to 91mol% (ZrO
2/ Y
2o
3/ CeO
2): the ball milling mixing and carry out mist projection granulating in deionized water of the ratio of 9mol% (ZrC), obtains the granule that granularity is 60 microns.Dry-pressing formed under 50MPa pressure again, then after the quiet molding such as 250MPa is cold, then in the high temperature furnace of Ar gas shielded, be incubated 2 hours with the ramp to 1400 of 3 DEG C/minute DEG C.To obtain ZrO after the speed of 1 DEG C/minute cooling
2-Y
2o
3-CeO
2-ZrC composite ceramics.
The crystal structure of this composite ceramics of X-ray diffraction analysis is Tetragonal, is 0.35 micron in the grain size of this composite ceramics of sem analysis.Carry out three-point bending resistance intensity and fracture toughness test at mechanics machine, bending strength is 1300MPa, and fracture toughness is 12.8MPa.m1/2.This composite ceramics is through the pressure of 0.2MPa in water vapour 134 DEG C of hydrothermal treatment consists 5 hours, and its bending strength is 1260MPa, and toughness is 12.5MPa.m1/2, and monoclinic phase content is 2%, and predominate texture is still Tetragonal.There is good aging resistance.
Embodiment 4c prepares ZrO
2-Y
2o
3-CeO
2-ZrC composite ceramics
ZrO prepared by embodiment 2b
2/ Y
2o
3/ CeO
2composite granule and particle mean size are that the ZrC of 30 nanometers is according to 94mol% (ZrO
2/ Y
2o
3/ CeO
2): the ball milling mixing and carry out mist projection granulating in deionized water of the ratio of 6mol% (ZrC), obtains the granule that granularity is 60 microns.Dry-pressing formed under 50MPa pressure again, then after the quiet molding such as 250MPa is cold, then in the high temperature furnace of Ar gas shielded, be incubated 2 hours with the ramp to 1400 of 3 DEG C/minute DEG C.To obtain ZrO after the speed of 1 DEG C/minute cooling
2-Y
2o
3-CeO
2-ZrC composite ceramics.
The crystal structure of this composite ceramics of X-ray diffraction analysis is Tetragonal, is 0.35 μm in the grain size of this composite ceramics of sem analysis.Carry out three-point bending resistance intensity and fracture toughness test at mechanics machine, bending strength is 1210MPa, and fracture toughness is 12.2MPa.m1/2.This composite ceramics is through the pressure of 0.2MPa in water vapour 134 DEG C of hydrothermal treatment consists 5 hours, and its bending strength is 1150MPa, and toughness is 11.8MPa.m1/2, and monoclinic phase content is 3%, and predominate texture is still Tetragonal.There is good aging resistance.
Embodiment 4d prepares ZrO
2-Y
2o
3-CeO
2-ZrC composite ceramics
ZrO prepared by embodiment 2b
2/ Y
2o
3/ CeO
2composite granule and particle mean size are that the ZrC of 30 nanometers is according to 91mol% (ZrO
2/ Y
2o
3/ CeO
2): the ball milling mixing and carry out mist projection granulating in deionized water of the ratio of 9mol% (ZrC), obtains the granule that granularity is 60 microns.Dry-pressing formed under 50MPa pressure again, then after the quiet molding such as 250MPa is cold, then in the high temperature furnace of Ar gas shielded, be incubated 2 hours with the ramp to 1400 of 3 DEG C/minute DEG C.To obtain ZrO after the speed of 1 DEG C/minute cooling
2-Y
2o
3-CeO
2-ZrC composite ceramics.
The crystal structure of this composite ceramics of X-ray diffraction analysis is Tetragonal, is 0.35 micron in the grain size of this composite ceramics of sem analysis.Carry out three-point bending resistance intensity and fracture toughness test at mechanics machine, bending strength is 1320MPa, and fracture toughness is 12.9MPa.m1/2.This composite ceramics is through the pressure of 0.2MPa in water vapour 134 DEG C of hydrothermal treatment consists after 5 hours, and its bending strength is 1310MPa, and toughness is 12.9MPa.m1/2, and inspection does not measure monoclinic phase content, and crystal structure is still Tetragonal.There is good aging resistance.
The capital preparation of embodiment 5 hip replacement zirconia-based ceramics
In above-mentioned example 3-4d, when dry-pressing formed, adopt the rubber mold of hip replacement femoral head shape.Thus obtain spherical zirconia base composite ceramics sintered body after sintering.This spherical sintered body is prepared into hip joint composite ceramics femoral head prosthesis through attrition process.
The preparation of zirconia-based ceramics prosthese of embodiment 6 knee prosthesis
In above-mentioned example 3-4d, when dry-pressing formed, adopt the rubber mold of knee-joint prosthesis tibial plateau holder shape.Thus obtain the zirconia base composite ceramics sintered body of tibial plateau holder shape after sintering.Knee prosthesis zirconia base composite ceramics prosthese is prepared into through attrition process.
Claims (10)
1. bone implanting prosthetic zirconia base composite ceramics, is become to be grouped into by following: the ZrO of 78-93mol%
2, 5-20mol% one or more stabilizing agents of ZrC and 2-12mol%, wherein said stabilizing agent is selected from by Y
2o
3, Al
2o
3, CaO, MgO and CeO
2the group formed.
2. bone implanting prosthetic zirconia base composite ceramics according to claim 1, is become to be grouped into by following: the ZrO of 85-93mol%
2, 5-13mol% the Y of ZrC and 2-5mol%
2o
3.
3. bone implanting prosthetic zirconia base composite ceramics according to claim 2, is become to be grouped into by following: the ZrO of 87-91mol%
2, 7-10mol% the Y of ZrC and 2-4mol%
2o
3.
4. bone implanting prosthetic zirconia base composite ceramics according to claim 1, is become to be grouped into by following: the ZrO of 78-91mol%
2, 5-10mol% the Y of ZrC, 1-3mol%
2o
3with the CeO of 3-9mol%
2.
5. bone implanting prosthetic zirconia base composite ceramics according to claim 4, is become to be grouped into by following: the ZrO of 78-89mol%
2, 5-10mol% the Y of ZrC, 1-3mol%
2o
3with the CeO of 5-9mol%
2.
6. bone implanting prosthetic zirconia base composite ceramics according to claim 5, is become to be grouped into by following: the ZrO of 78-85mol%
2, 7-10mol% the Y of ZrC, 1-3mol%
2o
3with the CeO of 7-9mol%
2.
7., according to the bone implanting prosthetic zirconia base composite ceramics of above-mentioned arbitrary claim, its grain size is less than 0.5 micron.
8. bone implanting prosthetic zirconia base composite ceramics according to claim 7, its three-point bending resistance intensity is greater than 1000MPa, and fracture toughness is greater than 10MPa.m
1/2.
9. the method for the bone implanting prosthetic zirconia base composite ceramics that manufacturing claims 1-8 is arbitrary, comprising: 1) prepare ZrO
2with the composite powder of stabilizing agent, powder size is less than 100 nanometers; 2) by 1) in the composite powder that obtains and granularity be less than the ZrC powder of 100 nanometers after wet-mixed 1-48 hour, mist projection granulating; 3) by 2) in the powder that obtains after pelletize suppress under uniaxial pressure under the pressure of 20-100MPa, obtain a base substrate; 4) by 3) in molded body cold isostatic compaction under 200-280MPa pressure of obtaining, obtain secondary base substrate; 5) by 4) in secondary base substrate after cold isostatic compaction put into the sintering furnace of Ar gas shielded, at 1350-1500 DEG C of sintering 1-5 hour.
10. bone implanting prosthetic prepared by the bone implanting prosthetic zirconia base composite ceramics utilizing claim 1-8 arbitrary, comprises hip replacement artificial thigh bone and liner and knee prosthesis knee-joint prosthesis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210529626.2A CN103044024B (en) | 2012-12-11 | 2012-12-11 | Bone implanting prosthetic zirconia base composite ceramics and bone implanting prosthetic prepared therefrom |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210529626.2A CN103044024B (en) | 2012-12-11 | 2012-12-11 | Bone implanting prosthetic zirconia base composite ceramics and bone implanting prosthetic prepared therefrom |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103044024A CN103044024A (en) | 2013-04-17 |
| CN103044024B true CN103044024B (en) | 2015-08-19 |
Family
ID=48056912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210529626.2A Active CN103044024B (en) | 2012-12-11 | 2012-12-11 | Bone implanting prosthetic zirconia base composite ceramics and bone implanting prosthetic prepared therefrom |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103044024B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103232237A (en) * | 2013-04-18 | 2013-08-07 | 上海大学 | Preparation method of normal-pressure-sintered transparent zirconium oxide ceramic material |
| CN104193331B (en) * | 2014-07-30 | 2016-07-06 | 北京固圣生物科技有限公司 | Bone implants prosthese zirconia base composite ceramics and bone prepared therefrom implants prosthese |
| CN105984019A (en) * | 2015-02-13 | 2016-10-05 | 苏州博恩瑞科生物材料有限公司 | Pressing forming method of ceramic friction pair |
| CN106187174A (en) * | 2015-03-31 | 2016-12-07 | 丁永新 | The preparation method of artificial joint bulb zirconia ceramics |
| CN105948740A (en) * | 2016-04-29 | 2016-09-21 | 华泽庆 | Preparation method of zirconia bio-ceramic material with diatomite and various toughening agents |
| CN107213528A (en) * | 2017-05-31 | 2017-09-29 | 苏州蔻美新材料有限公司 | A kind of preparation method of degradable bone implant |
| CN110540426B (en) * | 2019-10-11 | 2022-04-08 | 石家庄高新区亿成科技有限公司 | Zirconia-based biological ceramic material and preparation method and application thereof |
| CN115304372A (en) * | 2021-05-07 | 2022-11-08 | 苏州宸泰医疗器械有限公司 | Zirconia composite ceramic and bone implant prosthesis prepared from same |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1699270A (en) * | 2005-05-17 | 2005-11-23 | 杭州市萧山区中医院 | Preparation method of hydroxyapatite/zirconium dioxide biological ceramic composite material and its products |
| CN102665971A (en) * | 2009-09-30 | 2012-09-12 | 生物涂层有限公司 | Method for the realization of biologically compatible prosthesis |
-
2012
- 2012-12-11 CN CN201210529626.2A patent/CN103044024B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1699270A (en) * | 2005-05-17 | 2005-11-23 | 杭州市萧山区中医院 | Preparation method of hydroxyapatite/zirconium dioxide biological ceramic composite material and its products |
| CN102665971A (en) * | 2009-09-30 | 2012-09-12 | 生物涂层有限公司 | Method for the realization of biologically compatible prosthesis |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103044024A (en) | 2013-04-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103044024B (en) | Bone implanting prosthetic zirconia base composite ceramics and bone implanting prosthetic prepared therefrom | |
| JP6688838B2 (en) | Zirconia sintered body, zirconia composition and calcined body | |
| Palmero et al. | Towards long lasting zirconia-based composites for dental implants. Part I: Innovative synthesis, microstructural characterization and in vitro stability | |
| Nevarez-Rascon et al. | On the wide range of mechanical properties of ZTA and ATZ based dental ceramic composites by varying the Al2O3 and ZrO2 content | |
| CN104193331B (en) | Bone implants prosthese zirconia base composite ceramics and bone prepared therefrom implants prosthese | |
| Ai et al. | Microstructure and properties of Al2O3 (n)/ZrO2 dental ceramics prepared by two-step microwave sintering | |
| WO2008013099A1 (en) | Sintered zirconia having high light transmission and high strength, use of the same and process for production thereof | |
| JP2011225567A (en) | Composite ceramic material containing zirconia | |
| Fan et al. | Microstructure and cytotoxicity of Al2O3-ZrO2 eutectic bioceramics with high mechanical properties prepared by laser floating zone melting | |
| Yang et al. | Influence of nano-ZrO2 additive on the bending strength and fracture toughness of fluoro-silicic mica glass–ceramics | |
| CN114829319A (en) | Method for producing workable zirconia composite sintered body, raw material composition for workable zirconia composite sintered body, and workable zirconia composite calcined body | |
| Shuai et al. | Hydroxyapatite whisker reinforced 63s glass scaffolds for bone tissue engineering | |
| Tan et al. | Physical and biological implications of accelerated aging on stereolithographic additive-manufactured zirconia for dental implant abutment | |
| Wang et al. | Fabrication of highly translucent yttria-stabilized zirconia ceramics using stereolithography-based additive manufacturing | |
| Kwon et al. | Evaluation of mechanical properties of dental zirconia in different milling conditions and sintering temperatures | |
| CN109678524A (en) | A kind of silicon nitride ceramics implantation material and preparation method thereof that performance is controllable | |
| US9353010B2 (en) | Alumina-zirconia ceramic implants and related materials, apparatus, and methods | |
| JP2002362972A (en) | Zirconia ceramics for living organism and method of manufacturing for the same | |
| CN109467441A (en) | The preparation method of bio-medical silicon nitride compositions and silicon nitride ceramics | |
| US20240033186A1 (en) | Zirconia sintered body containing needle-shaped metal oxide | |
| Gunduz et al. | Effect of yttria-doping on mechanical properties of bovine hydroxyapatite (BHA) | |
| WO2023127792A1 (en) | Zirconia sintered body and method for producing same | |
| CN115304370A (en) | Zirconia-yttrium aluminum garnet composite ceramic and bone implant prosthesis prepared from same | |
| Parvin | Structural and mechanical properties of Al2O3-ZrO2 dental bioceramics | |
| Hussein | Synthesis of Nano Calcium Oxide from Cockle Shells as Stabilizer for Fabrication of Zirconia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| PP01 | Preservation of patent right | ||
| PP01 | Preservation of patent right |
Effective date of registration: 20200605 Granted publication date: 20150819 |
|
| PD01 | Discharge of preservation of patent |
Date of cancellation: 20201106 Granted publication date: 20150819 |
|
| PD01 | Discharge of preservation of patent | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20210322 Address after: 400000 6-1, unit 1, building 7, No.2, Aoyun Road, Jiulongpo District, Chongqing Patentee after: Zheng Bin Address before: 100094 door 2, building 1, 103 Beiqing Road, Haidian District, Beijing Patentee before: BEIJING GUSHENG BIOTECHNOLOGY Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20220406 Address after: 215000 room 510-c18, building 2, No. 8, Jinfeng Road, science and Technology City, high tech Zone, Suzhou, Jiangsu Province Patentee after: Suzhou chentai Medical Instrument Co.,Ltd. Address before: 400000 6-1, unit 1, building 7, No.2, Aoyun Road, Jiulongpo District, Chongqing Patentee before: Zheng Bin |
|
| TR01 | Transfer of patent right |