CN103041365B - Medicament for treating gastric ulcer - Google Patents
Medicament for treating gastric ulcer Download PDFInfo
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- CN103041365B CN103041365B CN201310021502.8A CN201310021502A CN103041365B CN 103041365 B CN103041365 B CN 103041365B CN 201310021502 A CN201310021502 A CN 201310021502A CN 103041365 B CN103041365 B CN 103041365B
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Abstract
The invention discloses a medicament for treating gastric ulcer. In the traditional herbal medicine, endothelium corneum gigeriae galli, fructus amomi, dandelion, radix bupleuri, thunberg fritillary bulb, white paeony root, bletilla striata and rhizoma nardostachyos are used as monarch drugs in a prescription and can stop pain and blood, invigorate stomach and recover gastric mucosa; scorched gastric mucosa, scorched hawthorn fruit, scorched medicated leaven, dried tangerine peels, houttuynia cordata and dry ginger are used as ministerial drugs in the prescription and can invigorate stomach to digest and conveniently and radically cure the gastric ulcer; pseudo-ginseng, Chinese rhubarb and Yunnan baiyao are used as adjuvant drugs in the prescription and can stop pain, diminish inflammation, stop the blood and accelerate the recovery of the gastric mucosa; and ginseng, red dates, persimmon frost and licorice root are used as conductant drugs and can regulate the stomach to make other components play a maximum role. The medicament has the advantages of high curing rate, no side effects, less possibility of recurrence and low curing cost.
Description
Technical field
The present invention relates to a kind of Chinese medicine, specifically, relate to a kind of medicine for the treatment of gastric ulcer.
Background technology
Peptic ulcer refers to the tissue injury that surpasses muscular layer of mucosa that gastrointestinal mucosa is caused by peptic digestion liquid autodigestion, can betide gastral any position, wherein common with stomach and duodenum, be gastric ulcer and duodenal ulcer, its cause of disease, clinical symptoms and Therapeutic Method are substantially similar, clarify a diagnosis main by gastroscopy.Gastric ulcer is modal a kind of in peptic ulcer, mainly refers to the tissue injury that surpasses muscular layer of mucosa that gastric mucosa is caused by peptic digestion liquid autodigestion.
Gastric ulcer symptom is not often true to type and can shows as upper abdominal pain and epigastric discomfort etc.The overwhelming majority people can there are various dyspeptic symptoms, but have also without any symptom, until develop complications.That its common complication mainly contains is hemorrhage, perforation, pyloric obstruction, canceration.Common gastrointestinal symptom and General Symptoms mainly contain burn feeling after belch, acid regurgitation, big belly, breastbone, feel sick, vomiting, poor appetite etc.After acid regurgitation and breastbone, burn feeling is due to cardiochalasia, feels sick, vomits many reflection ulcer and may point out ulcer in active stage.Frequent vomiting dyspepsia, prompting pyloric obstruction.Some patients were has autonomic nervous dysfunction's symptoms such as insomnia, hyperhidrosis.
The feature of gastric ulcer Upper abdominal pain:
1, chronic process: except minority is compared with the patient of Seek early medical advice, the most of patients course of disease has reached several years, the more than ten years or longer time.
2, periodically: Most patients Relapse rate outbreak, and stage of attack and catabasis with conversion in season, psychentonia, anxious state of mind, diet is uncomfortable or take the variation appearance alternate with each other with the relevant factors such as medicine of falling ill.Ulcer acute active stage, the repetitive process in healing, ulotic ulcer cycle of shape have gradually been reflected.Stage of attack, can reach several months even several weeks, and the catabasis can be grown to several months or several years.Seizure frequency and outbreak and catabasis hold time, because of patient's individual variation and the development of ulcer and therapeutic effect and to consolidate the measure of curative effect different.
3, rhythmicity: ulcer Theory of Pain Mechanism mainly stimulates ulcer surface relevant with too much gastric acid secretion, therefore the Peptic Ulcers pain of different parts has different regularity.Gastric ulcer pain is many continues 1～2 hour occurring half an hour after the meal, fades away, and after again having meal, pain repeats, so iterative cycles.When gastric ulcer is positioned at pyloric canal place or with duodenal ulcer simultaneously and while depositing, the pain rhythm and pace of moving things can be identical with duodenal ulcer.But the pain rhythmicity of the Peptic Ulcers of some specific type is not clearly, as old people's ulcer and postbulbar duodenal ulcer etc.It should be noted that when the rhythmicity of pain changes suddenly, should consider that the state of an illness develops to some extent, maybe may occur other complication.
4, the position of pain: gastric ulcer pain multidigit hits exactly or takes back under xiphoid-process, pain dimensions generally limits to, and there is tenderness part, but the position of pain might not be exactly the position at ulcer place.When ulcer deeply reaches placenta percreta or is penetrating ulcer, pain can diffuse to other positions of health such as chest, upper left abdomen, Fu Huo back, upper right.
5, the character of pain and degree: everyone differs to the tolerance degree of pain, therefore the objective standard of degree neither one of Peptic Ulcers pain, its character, also depending on patient's sensation, is described to hungry sample sense of discomfort, dull pain, belch, constriction, causalgia or severe pain and twinge etc. conventionally.
Pathogenic factor:
In gastral cavity, gastric acid and pepsin are digestion materials important in gastric juice.Gastric acid is highly acid material, has stronger aggressivity; Pepsin has the effect of aminosal, can destroy the protein on coat of the stomach, yet, under the existence of these factors of erosion, gastrointestinal tract still can be resisted and maintain the integrity of mucosa and the function of self, and it is mainly because Grastiodudenal mucosa also has series of defence and repair mechanism.We are referred to as damage mechanism by gastric acid and pepsic harmful aggressivity, and the defence that gastrointestinal tract self is had and repair mechanism are referred to as protection mechanism.Think that at present the protection mechanism of normal person's gastroduodenal mucosa is enough to resist gastric acid and pepsic erosion.But, when some factor has damaged that certain link in protection mechanism just may occur that gastric acid and protease corrode self mucosa and the formation that causes ulcer.When excessive gastric acid secretion also may cause ulcer to occur considerably beyond the defence of mucosa and repair.In recent years research shows, helicobacter pylori and NSAID (non-steroidal anti-inflammatory drug) be the infringement gastrointestinal protection mechanism most commonly encountered diseases that causes ulcer morbidity because of, gastric acid plays a crucial role in ulcer.In addition, medicine, stress, hormone also can cause the generation of ulcer, the appearance that various psychological factor and bad dietetic life custom can induced ulcers
Therapeutic Method mainly contains at present: Drug therapy, eliminating pylorus treatment, operative treatment.
1, the target of Drug therapy is eliminated exactly the cause of disease and is controlled symptom, promotes ulcer healing, prevention of recurrence and avoid complication.
The most frequently used medicine is divided into following a few class at present:
(1), gastric acid secretion inhibiting medicine: mainly contain clinically at present bisfentidine (H2-RA) and proton pump inhibitor (PPI).The gastric acid secretion that H2-RA can suppress basis and stimulate is conventional as cimetidine, ranitidine, famotidine and nizatidine; PPI acts on the key enzyme H+-K+ATP enzyme in the whole last step of parietal cell gastric acid secretion, makes its irreversible inactivation, and Acidinhibitor is stronger and effect is lasting.PPI promotes that speed, the healing rate of ulcer healing are higher, treatment when being applicable to various intractable ulcers or NSAID ulcer patient and can not stopping using NSAID, also can be used for Helicobacter pylori eradication for treatment with antibiotic synergism, be therefore the first-selected medication of gastric ulcer.Conventional PPI has omeprazole, lansoprazole, rabeprazole, esomeprazole, ilaprazole etc.
(2), mucosa protective agent: do not belonged at present a line medication of treat ulcer, but with press down after sour medicine coupling, it can improve ulcer healing quality, minimizing ulcer recurrence is common as sucralfate, denol, bismuth potassium citrate, misoprostol etc.
(3), digestive tract power reinforcing medicine: be mainly used in the patient of the symptoms such as appearance is felt sick, vomiting, abdominal distention to promote gastrointestinal emptying, relief of symptoms.
2, eliminating pylorus treatment
As previously mentioned, helicobacter pylori is one of major reason of gastric ulcer generation, so the patient of Helicobacter pylori, should give Helicobacter pylori eradication for treatment, and it not only can promote ulcer healing, can also prevent ulcer recurrence, thereby thoroughly cures ulcer.
There is no at present effectively eradicate helicobacter pylori of single medicine, therefore must drug combination.Anti-helicobacter pylori associated guideline and common recognition in the world in recent years, the first-line treatment scheme of recommendation is to take PPI as basis, to add two kinds of antibiotic Triple therapy schemes, 7 days～14 days course for the treatment of.Clinical confirmation its have that curative effect is high, toleration and the advantage such as compliance is good.There is the antibiosis of killing helicobacter pylori activity and have clarithromycin, amoxicillin, metronidazole (or tinidazole), tetracycline, furazolidone, some quinolione class as levofloxacin magnitude.In PPI and denol body, can suppress helicobacter pylori, have Synergistic biocidal effect with above-mentioned antibiosis.The treatment of ulcer is generally 4-6 week course for the treatment of, and part need to maintain 8 weeks, and the front treatment that is generally eliminating pylorus for 2 weeks continues to give the medicine after treatment of gastric acid secretion inhibiting and protection gastric mucosa subsequently.Because treatment cycle is relatively long, therefore need patient actively to coordinate, adhere to taking medicine, only in this way could effectively control the state of an illness of gastric ulcer.
3, operative treatment
The treatment of Peptic Ulcers is at present quite ripe, and general ulcer does not need underwent operative treatment, only under following situation, just needs row operative treatment: massive hemorrhage medicine can not be controlled; Perforation; Cicatricial pyloric obstruction; The intractable ulcer that Drug therapy is invalid; Highly suspect canceration.
That complication mainly contains is hemorrhage, perforation, pyloric obstruction, canceration.
As a kind of common type in peptic ulcer, an important feature of gastric ulcer is that itself and psychological Nervous and Mental Factors are closely related.Patient's stress is often larger, various indigestion symptom cross occurrence due to its clinical symptoms and functional gastrointestinal disorder, therefore some patient is after the eradication therapy of enough courses for the treatment of, through endoscopy, confirm that ulcer heals, but it is not good enough that indigestion symptom is alleviated, and its main cause is that patient's mental burden is heavier, poor sleep, in the past for a long time, dyspeptic symptom only can be more and more serious.
Summary of the invention
The technical problem to be solved in the present invention is to overcome above-mentioned defect, provides a kind of side effect little, and treatment cost is low, but therapeutic effect is significantly treated the medicine of gastric ulcer.
For addressing the above problem, the technical solution adopted in the present invention is:
A medicine for the treatment of gastric ulcer, is characterized in that: described medicine comprises the Chinese medicine of following weight portion: Fructus Hordei Germinatus (parched to brown) 10-20 gram, Fructus Crataegi (parched to brown) 10-20 gram, Massa Medicata Fermentata (parched to brown) 10-20 gram, Endothelium Corneum Gigeriae Galli 10-20 gram, Pericarpium Citri Reticulatae 10-20, Rhizoma Zingiberis 5-10 gram, Radix Notoginseng 5-10 gram, Radix Ginseng 10-20 gram, Fructus Amomi 10-20 gram, Herba Houttuyniae 5-10 gram, Radix Et Rhizoma Rhei 5-10 gram, Fructus Jujubae 10-20 gram, Mannosum Kaki 5-10 gram, Radix Glycyrrhizae 10-20 gram, Herba Taraxaci 10-20 gram, YUNNAN BAIYAO 5-10 gram, Radix Bupleuri 10-20 gram, Bulbus Fritillariae Thunbergii 5-10 gram, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20 gram, Radix Paeoniae Alba 10-20 gram, Radix Et Rhizoma Nardostachyos 5-10 gram.
As a kind of improvement:
Described medicine comprises the Chinese medicine of following weight portion:
15 grams of Fructus Hordei Germinatus (parched to brown)s, 15 grams of Fructus Crataegi (parched to brown)s, 15 grams of Massa Medicata Fermentata (parched to brown), 15 grams of Endothelium Corneum Gigeriae Galli, 15 grams of Pericarpium Citri Reticulataes, 8 grams of Rhizoma Zingiberiss, 8 grams of Radix Notoginseng, 15 grams of Radix Ginsengs, 15 grams of Fructus Amomis, 7 grams of Herba Houttuyniae, 7 grams of Radix Et Rhizoma Rhei, 15 grams, Fructus Jujubae, 8 grams of Mannosum Kakis, 15 grams, Radix Glycyrrhizae, 15 grams of Herba Taraxacis, 8 grams of YUNNAN BAIYAO, 15 grams of Radix Bupleuri, 7 grams of Bulbus Fritillariae Thunbergiis, 15 grams of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 15 grams of the Radix Paeoniae Albas, 7 grams of Radix Et Rhizoma Nardostachyos.
As further improvement:
Described medicine comprises the Chinese medicine of following weight portion:
10 grams of Fructus Hordei Germinatus (parched to brown)s, 10 grams of Fructus Crataegi (parched to brown)s, 10 grams of Massa Medicata Fermentata (parched to brown), 10 grams of Endothelium Corneum Gigeriae Galli, 10 grams of Pericarpium Citri Reticulataes, 5 grams of Rhizoma Zingiberiss, 5 grams of Radix Notoginseng, 10 grams of Radix Ginsengs, 10 grams of Fructus Amomis, 5 grams of Herba Houttuyniae, 5 grams of Radix Et Rhizoma Rhei, 10 grams, Fructus Jujubae, 5 grams of Mannosum Kakis, 10 grams, Radix Glycyrrhizae, 10 grams of Herba Taraxacis, 5 grams of YUNNAN BAIYAO, 10 grams of Radix Bupleuri, 5 grams of Bulbus Fritillariae Thunbergiis, 10 grams of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10 grams of the Radix Paeoniae Albas, 5 grams of Radix Et Rhizoma Nardostachyos.
As further improving:
Described medicine comprises the Chinese medicine of following weight portion:
20 grams of Fructus Hordei Germinatus (parched to brown)s, 20 grams of Fructus Crataegi (parched to brown)s, 20 grams of Massa Medicata Fermentata (parched to brown), 20 grams of Endothelium Corneum Gigeriae Galli, 20 grams of Pericarpium Citri Reticulataes, 10 grams of Rhizoma Zingiberiss, 10 grams of Radix Notoginseng, 20 grams of Radix Ginsengs, 20 grams of Fructus Amomis, 10 grams of Herba Houttuyniae, 10 grams of Radix Et Rhizoma Rhei, 20 grams, Fructus Jujubae, 10 grams of Mannosum Kakis, 20 grams, Radix Glycyrrhizae, 20 grams of Herba Taraxacis, 10 grams of YUNNAN BAIYAO, 20 grams of Radix Bupleuri, 10 grams of Bulbus Fritillariae Thunbergiis, 20 grams of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 20 grams of the Radix Paeoniae Albas, 10 grams of Radix Et Rhizoma Nardostachyos.
Wherein, Fructus Hordei Germinatus (parched to brown) have aid digestion, blood sugar lowering, antifungal, inhibition prolactin antagonist be released into, to radioactive protective action.In the present invention, mainly utilize the digestant effect of Fructus Hordei Germinatus (parched to brown) for gastric ulcer indigestion symptom.
Fructus Crataegi (parched to brown) has dyspepsia and intestinal stasis relieving effect, is good at treatment with the profit of rushing down of food stagnation, and the present invention mainly utilizes the effect of Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving to regulate the diseases such as patients w ith peptic ulcer disease belch, dyspepsia.
Massa Medicata Fermentata (parched to brown) has the effect of promoting digestion and removing stagnation, invigorating the spleen and regulating the stomach.Be mainly used in retention of food and drink, dyspepsia, distension and fullness in the abdomen, inappetence, vomiting dysentery, and married woman's abdominalgia with blood stasis in puerperal, the disease such as children's's enlarged abdomen is hard long-pending.Can be used for clinically treating chronic gastritis, atrophic gastritis, acute gastroenteritis, amebic dysentery, the various diseases such as abdominal distention, stomachache, diarrhoea and infantile simple dyspepsia, anorexia, food stagnation.
Endothelium Corneum Gigeriae Galli has the effect of promoting digestion and invigorating the stomach, and after human oral Endothelium Corneum Gigeriae Galli, gastric secretion, acidity and eupepsy all have and increase, and gastric motor function obviously strengthens, and shows the prolongation of stomach moving period and the enhancing of peristalsis.Due to the enhancing of stomach motion, therefore, gastric emptying rate is also accelerated greatly, and the present invention mainly utilizes Endothelium Corneum Gigeriae Galli to strengthen the motion function of patients w ith peptic ulcer disease stomach, increases Emptying Rate.
Pericarpium Citri Reticulatae for insufficiency of the spleen diet reduce, dyspepsia, and the disease such as nausea and vomiting.This product dampness and can spleen benefiting and stimulating the appetite, be applicable to the diseases such as weakness of the spleen and stomach, diet minimizing, dyspepsia, loose stool and diarrhea, smooth muscle is had to inhibitory action, have antiinflammatory, antiulcer, choleretic effect, the present invention mainly utilizes Pericarpium Citri Reticulatae treatment weakness of the spleen and stomach, dyspepsia, antiulcer effect treatment patients w ith peptic ulcer disease digestive function is weak and ulcer.
Rhizoma Zingiberis has warming spleen and stomach for dispelling cold, and recuperating depleted YANG is promoted blood circulation, dampness expectorant, and the effect of warming the lung to resolve fluid-retention, has certain inhibitory action, particularly gastric ulcer to digestive system and ulcer.
Radix Notoginseng has hemostasis, antithrombotic, promotion hemopoietic, antitumor, analgesic activity, can treat gastrorrhagia, the atrophic lesion of gastric mucosa.In the present invention, mainly utilize pathological changes on Radix Notoginseng hemostasis, paroxysmal pain effect treatment patients w ith peptic ulcer disease gastrorrhagia and gastric mucosa.
Radix Ginseng has strongly invigorating primordial QI, multiple arteries and veins is admittedly de-, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, the effect of the Fructus Alpiniae Oxyphyllae of calming the nerves, scalable function of nervous system, make anxiety cause disorderly nervous process to be recovered, the adaptability that improves body, mainly utilizes Radix Ginseng to neural effect in the present invention, reduction of patient anxiety causes disorderly nervous system.
Fructus Amomi has removing dampness appetizing, warming spleen and stopping diarrha, the antiabortive effect of regulating the flow of vital energy.Use Fructus Amomi 0.3g/Kg, 0.6g/Kg, 1.2g/kg gastric infusion, has obvious inhibitory action to constraint water seaoning mice stress ulcer; 0.6g/kg gavage, can significantly reduce the gastric secretion of rat; Test tube is tested and is shown, Fructus Amomi can obviously suppress gastric enzyme digestible protein.The present invention mainly utilizes Fructus Amomi to suppress gastric enzyme digestible protein, eliminates the root of gastric ulcer gastroxia.
Herba Houttuyniae has the effect of heat-clearing and toxic substances removing, removing pus and relieving carbuncle, inducing diuresis for treating stranguria syndrome, promotes stomach blood circulation, is beneficial to the healing at stomach ulcer place.
Radix Et Rhizoma Rhei has effects such as attacking stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, removing toxic substances, and the present invention mainly utilizes Radix Et Rhizoma Rhei to attack the long-pending stagnant effect that disappears, and eliminates the symptoms such as patients w ith peptic ulcer disease belch, abdominal distention.
Fructus Jujubae has the effects such as tonify deficiency QI invigorating, nourishing blood to tranquillize the mind, invigorating the spleen and regulating the stomach.The present invention mainly utilizes the effect of Fructus Jujubae invigorating the spleen and regulating the stomach, and then eliminates gastric acid burning to stomach.
Mannosum Kaki has the lung-heat of clearing away heart-fire, promoting the production of body fluid to quench thirst, and flat the coughing of reducing phlegm, controls the effect of throat dispute skin ulcer pain, blood stasis in the abdomen that can disappear, spleen invigorating gastric qi, controls regurgitation spitting of blood.
Radix Glycyrrhizae has QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, the effect of coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.The present invention mainly utilizes the effect of Radix Glycyrrhizae treatment weakness of the spleen and stomach, to alleviate patients w ith peptic ulcer disease stomach discomfort, and cushions the stimulation of other Chinese herbal medicine to stomach.
Herba Taraxaci decoct has remarkable protective effect to rat oral gavage to stress ulcer; To dehydrated alcohol, caused gastric mucosa damage also has remarkable protective effect; And the formation that can obviously resist pylorus ligation rat gastric ulcer.So Herba Taraxaci can be treated the disease of stomach such as stomach ulcer and gastric mucosa injury effectively.
YUNNAN BAIYAO is all right blood stasis dispelling promoting blood circulation and stopping pain except hemostasia effect, removing toxic substances and promoting subsidence of swelling, enhancing human body immunity function, in YUNNAN BAIYAO, separated two kinds of Saponin I that propose and VI demonstrate certain active anticancer in P--388, L--1210 and 9KB tissue culture system screening test.In the present invention, utilize YUNNAN BAIYAO enhancing human body immunity function, reduce malignant change of benign gastric ulcer probability.
Radix Bupleuri has expelling pathogenic factors from the exterior to expel the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, and the effect of elevate a turnable ladder yang-energy, the present invention mainly utilizes Radix Bupleuri to remove stagnation of QI in the intestines and stomach, and diet gathers.
Bulbus Fritillariae Thunbergii has removing heat-phlegm, the effect of powder detoxifcation.The present invention mainly utilizes Bulbus Fritillariae Thunbergii treatment stomachache acid regurgitation symptom.
The Pseudobulbus Bletillae (Rhizoma Bletillae) has the effect of tonifying the lung, hemostasis, detumescence, granulation promoting, sore.Control that epistaxis, incised wound are hemorrhage, swollen ulcer drug, ulcer pain, soup fire are burnt, rhagadia manus et pedis.
The Radix Paeoniae Alba has nourishing blood to suppress the hyperactive liver, slow middle pain relieving, and yin fluid astringing is received antiperspirant.Paeoniflorin in the Radix Paeoniae Alba all shows inhibition to the intestine in vitro of Cavia porcellus, rat with in stomach motion and rat uterus smooth muscle, and the caused contraction of energy antagonism oxytocin; With acetic acid injection, in mouse peritoneal, using writhing response as the index of pain, paeoniflorin has significant analgesic effect, and paeoniflorin is to because intense and stimulative digestive tract in rats ulcer of bringing out has obvious inhibitory action.
Radix Et Rhizoma Nardostachyos has promoting the circulation of QI to relieve pain, the effect of relieving stagnation and activating the spleen, external damp eliminating detumescence.For burnt QI stagnated by cold, incoordination between the spleen and stomach, inappetence, vomiting.
Before said medicine is taken, need the step through the general preparation such as immersion, decoction, slagging-off traditional Chinese medicine liquid, finally obtain the medicinal liquid that can take, once-a-day, early bfore meals, five days courses for the treatment of, after the course for the treatment of, drug withdrawal continues next course for the treatment of for five days again, after three courses for the treatment of, just can fully recover.
In order further to verify the drug effect of medicine of the present invention, choose respectively 70 in various degree patients w ith peptic ulcer disease test, substantially be divided into four groups, wherein one group is matched group 16 examples, use Western medicine cimetidine and the esomeprazole of traditional treatment gastric ulcer, its excess-three group is respectively I group (lighter) 21 examples, II group (moderate) 18 examples, III group (severe) 15 examples by ulcer level, all takes medicine of the present invention, and concrete data as shown in Table 1.
Table one
As can be seen from Table I, the lighter I of gastric ulcer degree group effective percentage reaches 100%, and cure rate is also up to 92.5%, and without recurrence, has no side effect, and cures cost also low; The heavier II of gastric ulcer degree group effective percentage and cure rate are also higher, more than 88%, and have no side effect, and relapse rate is low, cure cost low; The effective percentage of the III group that gastric ulcer degree is heavier and cure rate are also all more than 85%, and few side effects, and relapse rate is low, and healing cost is relatively low; The matched group of, moderate slight as comprising and severe gastric ulcer, although effective percentage be that absolutely cure rate is low, is difficult for root, and relapse rate is up to more than 30%, healing cost is also relatively high.
In sum, in Chinese crude drug of the present invention, Endothelium Corneum Gigeriae Galli, Fructus Amomi, Herba Taraxaci, Radix Bupleuri, Bulbus Fritillariae Thunbergii, the Radix Paeoniae Alba, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Et Rhizoma Nardostachyos are monarch drug, can pain relieving, hemostasis, stomach invigorating, gastric mucosa reparation; Fructus Hordei Germinatus (parched to brown), Fructus Crataegi (parched to brown), Massa Medicata Fermentata (parched to brown), Pericarpium Citri Reticulatae, Herba Houttuyniae, Rhizoma Zingiberis are ministerial drug, and invigorating the stomach and promoting digestion is convenient to fundamentally cure gastric ulcer; Radix Notoginseng, Radix Et Rhizoma Rhei, YUNNAN BAIYAO are adjuvant drug, can pain relieving, antiinflammatory, hemostasis, accelerate the reparation of gastric mucosa; Radix Ginseng, Fructus Jujubae, Mannosum Kaki, Radix Glycyrrhizae be for making medicine, can with middle tune stomach, and can make other composition performance maximum effect.Owing to having adopted technique scheme, medicine of the present invention has advantages of that cure rate is high, has no side effect, is difficult for recurrence and cure cost low.
The specific embodiment
Embodiment 1: a kind of medicine for the treatment of gastric ulcer, and described medicine comprises the Chinese medicine of following weight portion:
15 grams of Fructus Hordei Germinatus (parched to brown)s, 15 grams of Fructus Crataegi (parched to brown)s, 15 grams of Massa Medicata Fermentata (parched to brown), 15 grams of Endothelium Corneum Gigeriae Galli, 15 grams of Pericarpium Citri Reticulataes, 8 grams of Rhizoma Zingiberiss, 8 grams of Radix Notoginseng, 15 grams of Radix Ginsengs, 15 grams of Fructus Amomis, 7 grams of Herba Houttuyniae, 7 grams of Radix Et Rhizoma Rhei, 15 grams, Fructus Jujubae, 8 grams of Mannosum Kakis, 15 grams, Radix Glycyrrhizae, 15 grams of Herba Taraxacis, 8 grams of YUNNAN BAIYAO, 15 grams of Radix Bupleuri, 7 grams of Bulbus Fritillariae Thunbergiis, 15 grams of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 15 grams of the Radix Paeoniae Albas, 7 grams of Radix Et Rhizoma Nardostachyos.
By above-mentioned weight, get respectively described Chinese medicine material, after mixing, soak 30 minutes, then pour in crucible temperature fire into and decoct 1 hour, filtering medicinal residues, just drinkable medicinal liquid, once-a-day, take half an hour before breakfast, and five days is a course for the treatment of, takes after a course for the treatment of drug withdrawal five days, as do not fully not recovered and can take again a course for the treatment of, general recovery from illness one to three course for the treatment of.
Embodiment 2: a kind of medicine for the treatment of gastric ulcer, and described medicine comprises the Chinese medicine of following weight portion:
10 grams of Fructus Hordei Germinatus (parched to brown)s, 10 grams of Fructus Crataegi (parched to brown)s, 10 grams of Massa Medicata Fermentata (parched to brown), 10 grams of Endothelium Corneum Gigeriae Galli, 10 grams of Pericarpium Citri Reticulataes, 5 grams of Rhizoma Zingiberiss, 5 grams of Radix Notoginseng, 10 grams of Radix Ginsengs, 10 grams of Fructus Amomis, 5 grams of Herba Houttuyniae, 5 grams of Radix Et Rhizoma Rhei, 10 grams, Fructus Jujubae, 5 grams of Mannosum Kakis, 10 grams, Radix Glycyrrhizae, 10 grams of Herba Taraxacis, 5 grams of YUNNAN BAIYAO, 10 grams of Radix Bupleuri, 5 grams of Bulbus Fritillariae Thunbergiis, 10 grams of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10 grams of the Radix Paeoniae Albas, 5 grams of Radix Et Rhizoma Nardostachyos.
By above-mentioned weight, get respectively described Chinese medicine material, after mixing, soak 30 minutes, then pour in crucible temperature fire into and decoct 1 hour, filtering medicinal residues, just drinkable medicinal liquid, once-a-day, take half an hour before breakfast, and five days is a course for the treatment of, takes after a course for the treatment of drug withdrawal five days, as do not fully not recovered and can take again a course for the treatment of, general recovery from illness one to three course for the treatment of.
Embodiment 3: a kind of medicine for the treatment of gastric ulcer, and described medicine comprises the Chinese medicine of following weight portion:
20 grams of Fructus Hordei Germinatus (parched to brown)s, 20 grams of Fructus Crataegi (parched to brown)s, 20 grams of Massa Medicata Fermentata (parched to brown), 20 grams of Endothelium Corneum Gigeriae Galli, 20 grams of Pericarpium Citri Reticulataes, 10 grams of Rhizoma Zingiberiss, 10 grams of Radix Notoginseng, 20 grams of Radix Ginsengs, 20 grams of Fructus Amomis, 10 grams of Herba Houttuyniae, 10 grams of Radix Et Rhizoma Rhei, 20 grams, Fructus Jujubae, 10 grams of Mannosum Kakis, 20 grams, Radix Glycyrrhizae, 20 grams of Herba Taraxacis, 10 grams of YUNNAN BAIYAO, 20 grams of Radix Bupleuri, 10 grams of Bulbus Fritillariae Thunbergiis, 20 grams of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 20 grams of the Radix Paeoniae Albas, 10 grams of Radix Et Rhizoma Nardostachyos.
By above-mentioned weight, get respectively described Chinese medicine material, after mixing, soak 30 minutes, then pour in crucible temperature fire into and decoct 1 hour, filtering medicinal residues, just drinkable medicinal liquid, once-a-day, take half an hour before breakfast, and five days is a course for the treatment of, takes after a course for the treatment of drug withdrawal five days, as do not fully not recovered and can take again a course for the treatment of, general recovery from illness one to three course for the treatment of.
Classical case:
Case 1, Lee, man, 42 years old, Qingzhou City boss self-employed entrepreneurs, because long-time excessive drinking causes stomach discomfort, cardinal symptom: upper abdominal pain, dyspepsia, belch, acid regurgitation, nauseating, vomiting, be moderate gastric ulcer after diagnosing, take after medicine of the present invention after the course for the treatment of, symptom fades away, and appearance has no side effect during medication, after two courses for the treatment of, fully recover, nothing recurrence in a year.
Case 2, Wang, man, 50 years old, Qingzhou City innings deputy bureau director, due to work relationship, drink all the year round, cause stomach hurt like hell, concrete symptom: upper abdominal pain, belch, acid regurgitation, burn feeling after breastbone, feel sick, vomiting, in vomitus with the blood streak, through hospital diagnosis, be that moderate lays particular stress on gastric ulcer, take medicine of the present invention after the course for the treatment of, pain relief, belch, acid regurgitation, after breastbone, burn feeling disappears, feel sick, vomiting number of times greatly reduces, after two courses for the treatment of, above-mentioned symptom disappears substantially, after taking again a course for the treatment of, fully recover, so far without recurrence, and appearance has no side effect during treating.
Case 3, summer, female, 26 years old, Qingzhou City company clerk, because diet was irregular all the year round, cause stomach discomfort, once in a while with pain, cardinal symptom is epigastric discomfort, belch, acid regurgitation, big belly, feel sick, vomiting, poor appetite, is light moderate gastric ulcer after diagnosing, take medicine of the present invention after the course for the treatment of, transference cure, is almost recovered, in the period in a medicine appearance that has no side effect.
Case 4, Ma, man, 68 years old, Qingzhou City retired worker, excessive drinking all the year round, causes the serious ulcer of stomach, and with complication such as hemorrhage, perforation, through hospital diagnosis, be severe gastric ulcer, and at any time may canceration, patient selects expectant treatment, therefore adopt medicine of the present invention, patient takes pain relief after a course for the treatment of, bleeding disappears, and continues to take after two courses for the treatment of, and symptom disappears substantially, gastric ulcer recovery from illness, during appearances that have no side effect, recovery from illness is so far without recurring.
Case 5, Zheng, female, 45 years old, the performer of Qingzhou City modern drama troup, because operating pressure is large, adds climacteric, inappetence in a period of time, and diet is irregular, cause stomach discomfort, and with pain, belch, acid regurgitation, also feeling sick once in a while, vomit, is moderate gastric ulcer through hospital diagnosis, and patient takes medicine of the present invention after the course for the treatment of, symptom fades away, and appetite increases, and continues to take after the course for the treatment of, transference cure, diet is normal, and recovery from illness is so far without recurrence.
Claims (4)
1. a medicine for the treatment of gastric ulcer, is characterized in that, described medicine is comprised of the Chinese medicine of following weight portion:
Fructus Hordei Germinatus (parched to brown) 10-20 gram, Fructus Crataegi (parched to brown) 10-20 gram, Massa Medicata Fermentata (parched to brown) 10-20 gram, Endothelium Corneum Gigeriae Galli 10-20 gram, Pericarpium Citri Reticulatae 10-20 gram, Rhizoma Zingiberis 5-10 gram, Radix Notoginseng 5-10 gram, Radix Ginseng 10-20 gram, Fructus Amomi 10-20 gram, Herba Houttuyniae 5-10 gram, Radix Et Rhizoma Rhei 5-10 gram, Fructus Jujubae 10-20 gram, Mannosum Kaki 5-10 gram, Radix Glycyrrhizae 10-20 gram, Herba Taraxaci 10-20 gram, YUNNAN BAIYAO 5-10 gram, Radix Bupleuri 10-20 gram, Bulbus Fritillariae Thunbergii 5-10 gram, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20 gram, Radix Paeoniae Alba 10-20 gram, Radix Et Rhizoma Nardostachyos 5-10 gram.
2. medicine according to claim 1, is characterized in that, described medicine is comprised of the Chinese medicine of following weight portion:
15 grams of Fructus Hordei Germinatus (parched to brown)s, 15 grams of Fructus Crataegi (parched to brown)s, 15 grams of Massa Medicata Fermentata (parched to brown), 15 grams of Endothelium Corneum Gigeriae Galli, 15 grams of Pericarpium Citri Reticulataes, 8 grams of Rhizoma Zingiberiss, 8 grams of Radix Notoginseng, 15 grams of Radix Ginsengs, 15 grams of Fructus Amomis, 7 grams of Herba Houttuyniae, 7 grams of Radix Et Rhizoma Rhei, 15 grams, Fructus Jujubae, 8 grams of Mannosum Kakis, 15 grams, Radix Glycyrrhizae, 15 grams of Herba Taraxacis, 8 grams of YUNNAN BAIYAO, 15 grams of Radix Bupleuri, 7 grams of Bulbus Fritillariae Thunbergiis, 15 grams of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 15 grams of the Radix Paeoniae Albas, 7 grams of Radix Et Rhizoma Nardostachyos.
3. medicine according to claim 1, is characterized in that, described medicine is comprised of the Chinese medicine of following weight portion:
10 grams of Fructus Hordei Germinatus (parched to brown)s, 10 grams of Fructus Crataegi (parched to brown)s, 10 grams of Massa Medicata Fermentata (parched to brown), 10 grams of Endothelium Corneum Gigeriae Galli, 10 grams of Pericarpium Citri Reticulataes, 5 grams of Rhizoma Zingiberiss, 5 grams of Radix Notoginseng, 10 grams of Radix Ginsengs, 10 grams of Fructus Amomis, 5 grams of Herba Houttuyniae, 5 grams of Radix Et Rhizoma Rhei, 10 grams, Fructus Jujubae, 5 grams of Mannosum Kakis, 10 grams, Radix Glycyrrhizae, 10 grams of Herba Taraxacis, 5 grams of YUNNAN BAIYAO, 10 grams of Radix Bupleuri, 5 grams of Bulbus Fritillariae Thunbergiis, 10 grams of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10 grams of the Radix Paeoniae Albas, 5 grams of Radix Et Rhizoma Nardostachyos.
4. medicine according to claim 1, is characterized in that, described medicine is comprised of the Chinese medicine of following weight portion:
20 grams of Fructus Hordei Germinatus (parched to brown)s, 20 grams of Fructus Crataegi (parched to brown)s, 20 grams of Massa Medicata Fermentata (parched to brown), 20 grams of Endothelium Corneum Gigeriae Galli, 20 grams of Pericarpium Citri Reticulataes, 10 grams of Rhizoma Zingiberiss, 10 grams of Radix Notoginseng, 20 grams of Radix Ginsengs, 20 grams of Fructus Amomis, 10 grams of Herba Houttuyniae, 10 grams of Radix Et Rhizoma Rhei, 20 grams, Fructus Jujubae, 10 grams of Mannosum Kakis, 20 grams, Radix Glycyrrhizae, 20 grams of Herba Taraxacis, 10 grams of YUNNAN BAIYAO, 20 grams of Radix Bupleuri, 10 grams of Bulbus Fritillariae Thunbergiis, 20 grams of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 20 grams of the Radix Paeoniae Albas, 10 grams of Radix Et Rhizoma Nardostachyos.
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| CN101766774A (en) * | 2010-04-07 | 2010-07-07 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicine composite for treating duodenal ulcer and preparation method thereof |
| CN101773633A (en) * | 2010-04-08 | 2010-07-14 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicine composition for treating gastric ulcer and preparation method thereof |
| CN102824587A (en) * | 2011-07-07 | 2012-12-19 | 随洪涛 | Traditional Chinese medicinal formula for treating gastropathy |
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| CN101766774A (en) * | 2010-04-07 | 2010-07-07 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicine composite for treating duodenal ulcer and preparation method thereof |
| CN101773633A (en) * | 2010-04-08 | 2010-07-14 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicine composition for treating gastric ulcer and preparation method thereof |
| CN102824587A (en) * | 2011-07-07 | 2012-12-19 | 随洪涛 | Traditional Chinese medicinal formula for treating gastropathy |
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