CN103041307A - Traditional Chinese medicine composition for curing chronic ulcerative colitis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for curing chronic ulcerative colitis and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for curing chronic ulcerative colitis. Bulk drugs of the traditional Chinese medicine composition include prepared rehmannia roots, vine of multiflower knotweed, myrrh, Chinese yam, rhizoma polygonati, myrobalan, asarum, rheum officinale, roots of Chinese pulsatilla, radix gentianae, folium isatidis, zedoary, roots of common vladimiria, fructus viticis, roots of red-rooted salvia, grifola, rhizoma bletillae, gallnut, pinellia ternate, alpinia oxyphylla, wadalee-gum-tree, saururus chinensis, groundsel, birthwort and perfoliote knotweed herb. The invention has the advantages that the traditional Chinese medicine composition has excellent curative effect, is quick to be effective, has low possibility of recurrence, has no toxic and side effect or side reaction, and has no drug resistance.
Description
Technical field
The present invention relates to the Chinese medicine technical field, relate in particular to a kind of Chinese medicine composition that is used for the treatment of chronic ulcerative colitis and preparation method thereof.
Background technology
Chronic ulcerative colitis (ulcerative colitis, UC) be a kind of agnogenic chronic nonspecific inflammatory bowel, chronic inflammatory disease and ulcer take intestinal mucosa sexually revise as feature, this disease clinical disease displacement is in large intestine, being the seriality diffusivity distributes, take colonic mucosa chronic inflammatory disease and ulcer as pathological characteristic, the part often exists obvious microcirculation disturbance.Clinical take symptoms such as diarrhoea, mucus bloody purulent stool, stomachache and tenesmus as feature, because of repeatedly outbreak, mucosa constantly destroys and repairs, causing normal configuration destroys, the colon distortion is shortened even the enteric cavity constriction, small number of patients generation colon carcinogenesis, Patients With Ulcerative Colitis colon cancer incidence rate compared with normal crowd is high 3~5 times generally.
The chronic ulcerative colitis etiology and pathogenesis is still not clear, and it is relevant with human body autoimmune mechanism, nature-nurture factor etc. that modern medicine is thought, pathological changes is mainly involved the sigmoid colorectum section.Many employing immunomodulators such as azathioprine, cyclosporin A are improved the effect of chronic ulcerative colitis symptom on the conventional western medical treatment.The cytokine monoclonal antibody of research in recent years and recombinant cytokine have been obtained breakthrough to the treatment of chronic ulcerative colitis, but late result waits to observe.Other are uncertain such as late results such as Biotherapeutics, intestinal microbial population adjustment.Adrenal Glucocorticoid is commonly used clinical with its non-specific antiinflammatory and immunosuppressive action, most of energy relief of symptoms, but be easy to recurrence after the drug withdrawal, and certain side effect is arranged.Other immunomodulator is not made routine administration because of its toxic and side effects yet, therefore, adopt western medicine should the disease initial stage very fast relief of symptoms, the clinical remission rate is high, but because easily recurrence, long-term prescription untoward reaction increase after the drug withdrawal, the drug resistance phenomenon occurs, reduced Quality of Life, curative effect is unsatisfactory.
The traditional Chinese medical science thinks that chronic ulcerative colitis surely belongs to the sick categories such as " having loose bowels ", " stomachache "." Required Readings for Medical Professionals " cloud: " having loose bowels, it is wet all to be formed in, wet all originally in insufficiency of the spleen." " Jing Yue's complete work is had loose bowels " cloud: " if intemperance of taking food, daily life frequently so that taste are injured, then instead for wet, Gu Fanwei's water stagnates, the gas of refining can not failing, and is cause to close dirty decline and dysentery is done." " have loose bowels originally, invariably because taste ... namely send out with touching, the dirty disease of this liver spleen two also.Lid is with the liver Wood restricts earth, the spleen being damaged and right ".As seen, irritability is not dredged, and contains in the weakness of the spleen and stomach, turbid damp to wait to be the principal element of this onste.Taste are impaired, and function of intestinal canal is disorderly, wet tired spleen soil, so that dysfunction of the spleen in transportation.The spleen has the function to transport and transform nutrients, and it is wet to like dry evil, and intestine and small intestine master department secretes, conducts; Liver controlling conveyance and dispersion is regulated spleen fortune, if spleen transporting not, depression of liver-QI, intestine and small intestine can not separating clear and excreting turbids, can't the development of evil in febrile disease, instead for wet, Gu Fanwei's water stagnates, close dirt and under must become to have loose bowels.Temper is impaired, and is wet from interior life, and with the passing of time humidity hysteresis how from transconversion into heat, damp and hotly accumulates steaming, stops up to stagnate between intestinal, and the blood network with the QI and blood knot of fighting, damages in conduction mistake department, the airsetting stasis, and blood loses the meat corruption, and internal ulceration becomes infections.Can involve in kidney with the passing of time again, asthenia of both the spleen and kidney, deficient vital QI leading to lingering of pathogen, touching difficulty is more.
Western medicine mainly is take symptomatic treatment as main, can not change patient's integral status.Chinese medicine has the advantage of whole adjustment, individualized treatment, compare with western medical treatment, the traditional Chinese medical science adopts different mechanism of action treatment chronic ulcerative colitis, it adjusts the whole body functional status by a plurality of target position, realizes the treatment to chronic ulcerative colitis, has good effect, instant effect, have no side effect and side reaction, recurrence is difficult, the advantage that has no drug resistance.
Summary of the invention
Technical problem to be solved by this invention is, a kind of Chinese medicine composition that is used for the treatment of chronic ulcerative colitis is provided, and with respect to Western medicine, it has good effect, instant effect, and difficult recurrence has no side effect and side reaction, difficult recurrence, the advantage that has no drug resistance.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine composition that is used for the treatment of chronic ulcerative colitis, its crude drug comprises Radix Rehmanniae Preparata, Caulis Polygoni Multiflori, Myrrha, Rhizoma Dioscoreae, Rhizoma Polygonati, Fructus Chebulae, Herba Asari, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Gentianae, Folium Isatidis, Rhizoma Wenyujin Concisum, Radix Vladimiriae, Fructus Viticis, Radix Salviae Miltiorrhizae, Polyporus, Pseudobulbus Bletillae (Rhizoma Bletillae), Galla Chinensis, the Rhizoma Pinelliae, Fructus Alpiniae Oxyphyllae, catechu, Rhizoma Saururi (Herba Saururi), Herba Senecionis Scandentis, Fructus Aristolochiae, Herba Polygoni cymosi.
Wherein, the weight portion of described each crude drug of Chinese medicine composition is respectively Radix Rehmanniae Preparata 33 weight portions ~ 43 weight portions, Caulis Polygoni Multiflori 27 weight portions ~ 37 weight portions, Myrrha 16 weight portions ~ 26 weight portions, Rhizoma Dioscoreae 41 weight portions ~ 51 weight portions, Rhizoma Polygonati 36 weight portions ~ 46 weight portions, Fructus Chebulae's 20 weight portions ~ 30 weight portions, Herba Asari 13 weight portions ~ 23 weight portions, Radix Et Rhizoma Rhei 22 weight portions ~ 32 weight portions, the Radix Pulsatillae 51 weight portions ~ 61 weight portions, Radix Gentianae 35 weight portions ~ 45 weight portions, Folium Isatidis 72 weight portions ~ 82 weight portions, Rhizoma Wenyujin Concisum 28 weight portions ~ 38 weight portions, Radix Vladimiriae 12 weight portions ~ 22 weight portions, Fructus Viticis 19 weight portions ~ 29 weight portions, Radix Salviae Miltiorrhizae 31 weight portions ~ 41 weight portions, Polyporus 29 weight portions ~ 39 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 30 weight portions ~ 40 weight portions, Galla Chinensis 25 weight portions ~ 35 weight portions, the Rhizoma Pinelliae 21 weight portions ~ 31 weight portions, Fructus Alpiniae Oxyphyllae 34 weight portions ~ 44 weight portions, catechu 16 weight portions ~ 26 weight portions, Rhizoma Saururi (Herba Saururi) 41 weight portions ~ 51 weight portions, Herba Senecionis Scandentis 22 weight portions ~ 32 weight portions, Fructus Aristolochiae 19 weight portions ~ 29 weight portions, Herba Polygoni cymosi 27 weight portions ~ 37 weight portions.
Wherein, the weight portion of described each crude drug of Chinese medicine composition is respectively Radix Rehmanniae Preparata 35 weight portions ~ 41 weight portions, Caulis Polygoni Multiflori 29 weight portions ~ 35 weight portions, Myrrha 18 weight portions ~ 24 weight portions, Rhizoma Dioscoreae 43 weight portions ~ 49 weight portions, Rhizoma Polygonati 38 weight portions ~ 44 weight portions, Fructus Chebulae's 22 weight portions ~ 28 weight portions, Herba Asari 15 weight portions ~ 21 weight portions, Radix Et Rhizoma Rhei 24 weight portions ~ 30 weight portions, the Radix Pulsatillae 53 weight portions ~ 59 weight portions, Radix Gentianae 37 weight portions ~ 43 weight portions, Folium Isatidis 74 weight portions ~ 80 weight portions, Rhizoma Wenyujin Concisum 30 weight portions ~ 36 weight portions, Radix Vladimiriae 14 weight portions ~ 20 weight portions, Fructus Viticis 21 weight portions ~ 27 weight portions, Radix Salviae Miltiorrhizae 33 weight portions ~ 39 weight portions, Polyporus 31 weight portions ~ 37 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 32 weight portions ~ 38 weight portions, Galla Chinensis 27 weight portions ~ 33 weight portions, the Rhizoma Pinelliae 23 weight portions ~ 29 weight portions, Fructus Alpiniae Oxyphyllae 36 weight portions ~ 42 weight portions, catechu 18 weight portions ~ 24 weight portions, Rhizoma Saururi (Herba Saururi) 43 weight portions ~ 49 weight portions, Herba Senecionis Scandentis 24 weight portions ~ 30 weight portions, Fructus Aristolochiae 21 weight portions ~ 27 weight portions, Herba Polygoni cymosi 29 weight portions ~ 35 weight portions.
Wherein, the dosage form of described Chinese medicine composition is powder, granule, oral liquid, pill, capsule, tablet.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, is specially:
The first step, with the Radix Pulsatillae, Radix Gentianae, Folium Isatidis, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Saururi (Herba Saururi), Herba Senecionis Scandentis and Herba Polygoni cymosi are pulverized, be mixed in proportion, obtain mixture, the adding determining alcohol is 70% ~ 80% the even moistening of ethanol, the mass ratio of mixture and ethanol is 1:1 ~ 1:2, and airtight placement 12h ~ 18h drops in the percolate pot, continue to add determining alcohol with respect to 2 ~ 4 times of mixture qualities and be 70% ~ 80% ethanol, continue dipping 6h ~ 12h, percolation, flow are per minute 5 ~ 7ml, collect percolate, to filter, filtrate is-0.06 at pressure~-0.04MPa, temperature is that concentrating under reduced pressure becomes the extractum of 65 ℃ of relative densities 1.15 ~ 1.20 under 65 ℃ of conditions;
Second step, with macroporous resin adsorption on the extractum, the quality of extractum and the mass ratio of macroporous adsorbent resin are 1:1 ~ 2, use first the water elution with respect to 0.3 ~ 0.5 times of the quality of macroporous adsorbent resin, using determining alcohol with respect to 4 ~ 6 times of the quality of macroporous adsorbent resin is 60% ~ 80% ethanol elution again, collects eluent, the concentrating under reduced pressure desolventizing, obtain and get dry extract, be ground into fine powder;
The 3rd step, remaining component is pulverized, be mixed in proportion, obtain mixture, decoct with water 3 times, the 1st amount of water is 8 times of mixture quality, decocts 2h, the 2nd time and the 3rd amount of water are 6 times of mixture quality, decoction liquor after each the decoction is all filtered, and merges filtrate, adds determining alcohol and is 70%~80% ethanol to alcohol volume content and reach 50%~60%, hold over night, again filter, filtrate be-0.08 at pressure~-0.06MPa, temperature are under 75 ℃ of conditions, concentrate desolventizing, obtain and get dry extract, be ground into fine powder;
In the 4th step, the fine powder and the 3rd that second step is obtained goes on foot the fine powder mixing that obtains, and spray drying according to needed dosage form, according to the conventional preparation method of each dosage form, is prepared into powder, granule, oral liquid, pill, capsule, tablet.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is granule, is specially:
The first step, with the Radix Pulsatillae, Radix Gentianae, Folium Isatidis, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Saururi (Herba Saururi), Herba Senecionis Scandentis and Herba Polygoni cymosi are pulverized, be mixed in proportion, obtain mixture, the adding determining alcohol is 70% ~ 80% the even moistening of ethanol, the mass ratio of mixture and ethanol is 1: 1 ~ 1:2, and airtight placement 12h ~ 18h drops in the percolate pot, continue to add determining alcohol with respect to 2 ~ 4 times of mixture qualities and be 70% ~ 80% ethanol, continue dipping 6h ~ 12h, percolation, flow are per minute 5 ~ 7ml, collect percolate, to filter, filtrate is-0.06 at pressure~-0.04MPa, temperature is that concentrating under reduced pressure becomes the extractum of 65 ℃ of relative densities 1.15 ~ 1.20 under 65 ℃ of conditions;
Second step, with macroporous resin adsorption on the extractum, the quality of extractum and the mass ratio of macroporous adsorbent resin are 1:1 ~ 2, use first the water elution with respect to 0.3 ~ 0.5 times of the quality of macroporous adsorbent resin, using determining alcohol with respect to 4 ~ 6 times of the quality of macroporous adsorbent resin is 60% ~ 80% ethanol elution again, collects eluent, the concentrating under reduced pressure desolventizing, obtain and get dry extract, be ground into fine powder;
The 3rd step, remaining component is pulverized, be mixed in proportion, obtain mixture, decoct with water 3 times, the 1st amount of water is 8 times of mixture quality, decocts 2h, the 2nd time and the 3rd amount of water are 6 times of mixture quality, decoction liquor after each the decoction is all filtered, and merges filtrate, adds determining alcohol and is 70%~80% ethanol to alcohol volume content and reach 50%~60%, hold over night, again filter, filtrate be-0.08 at pressure~-0.06MPa, temperature are under 75 ℃ of conditions, concentrate desolventizing, obtain and get dry extract, be ground into fine powder;
In the 4th step, the fine powder and the 3rd that second step is obtained goes on foot the fine powder mixing that obtains, spray drying, and adding determining alcohol is 75% ~ 85% ethanol soft material processed, granulate with oscillating granulator, oven dry under 60 ℃, granulate gets medicinal granule of the present invention.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is powder, is specially:
The first step, with the Radix Pulsatillae, Radix Gentianae, Folium Isatidis, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Saururi (Herba Saururi), Herba Senecionis Scandentis and Herba Polygoni cymosi are pulverized, be mixed in proportion, obtain mixture, the adding determining alcohol is 70% ~ 80% the even moistening of ethanol, the mass ratio of mixture and ethanol is 1: 1 ~ 1:2, and airtight placement 12h ~ 18h drops in the percolate pot, continue to add determining alcohol with respect to 2 ~ 4 times of mixture qualities and be 70% ~ 80% ethanol, continue dipping 6h ~ 12h, percolation, flow are per minute 5 ~ 7ml, collect percolate, to filter, filtrate is-0.06 at pressure~-0.04MPa, temperature is that concentrating under reduced pressure becomes the extractum of 65 ℃ of relative densities 1.15 ~ 1.20 under 65 ℃ of conditions;
Second step, with macroporous resin adsorption on the extractum, the quality of extractum and the mass ratio of macroporous adsorbent resin are 1:1 ~ 2, use first the water elution with respect to 0.3 ~ 0.5 times of the quality of macroporous adsorbent resin, using determining alcohol with respect to 4 ~ 6 times of the quality of macroporous adsorbent resin is 60% ~ 80% ethanol elution again, collects eluent, the concentrating under reduced pressure desolventizing, obtain and get dry extract, be ground into fine powder;
The 3rd step, remaining component is pulverized, be mixed in proportion, obtain mixture, decoct with water 3 times, the 1st amount of water is 8 times of mixture quality, decocts 2h, the 2nd time and the 3rd amount of water are 6 times of mixture quality, decoction liquor after each the decoction is all filtered, and merges filtrate, adds determining alcohol and is 70%~80% ethanol to alcohol volume content and reach 50%~60%, hold over night, again filter, filtrate be-0.08 at pressure~-0.06MPa, temperature are under 75 ℃ of conditions, concentrate desolventizing, obtain and get dry extract, be ground into fine powder;
In the 4th step, the fine powder and the 3rd that second step is obtained goes on foot the fine powder mixing that obtains, and spray drying obtains powder.
The present invention also provides a kind of Chinese medicinal composition granules that is used for the treatment of chronic ulcerative colitis, and its crude drug comprises Radix Rehmanniae Preparata, Caulis Polygoni Multiflori, Myrrha, Rhizoma Dioscoreae, Rhizoma Polygonati, Fructus Chebulae, Herba Asari, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Gentianae, Folium Isatidis, Rhizoma Wenyujin Concisum, Radix Vladimiriae, Fructus Viticis, Radix Salviae Miltiorrhizae, Polyporus, Pseudobulbus Bletillae (Rhizoma Bletillae), Galla Chinensis, the Rhizoma Pinelliae, Fructus Alpiniae Oxyphyllae, catechu, Rhizoma Saururi (Herba Saururi), Herba Senecionis Scandentis, Fructus Aristolochiae, Herba Polygoni cymosi.
The present invention also provides a kind of Chinese medicine composition composition powders that is used for the treatment of chronic ulcerative colitis, and its crude drug comprises Radix Rehmanniae Preparata, Caulis Polygoni Multiflori, Myrrha, Rhizoma Dioscoreae, Rhizoma Polygonati, Fructus Chebulae, Herba Asari, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Gentianae, Folium Isatidis, Rhizoma Wenyujin Concisum, Radix Vladimiriae, Fructus Viticis, Radix Salviae Miltiorrhizae, Polyporus, Pseudobulbus Bletillae (Rhizoma Bletillae), Galla Chinensis, the Rhizoma Pinelliae, Fructus Alpiniae Oxyphyllae, catechu, Rhizoma Saururi (Herba Saururi), Herba Senecionis Scandentis, Fructus Aristolochiae, Herba Polygoni cymosi.
The present invention also provide above-mentioned Chinese medicine composition for the preparation of the treatment chronic ulcerative colitis medicine in application.
Beneficial effect of the present invention:
The invention provides a kind of Chinese medicine composition that is used for the treatment of chronic ulcerative colitis, with respect to Western medicine, it has good effect, instant effect, and difficult recurrence has no side effect and side reaction, difficult recurrence, the advantage that has no drug resistance.
The specific embodiment
Primary disease be suffer from abdominal pain, tenesmus, bloody purulent stool be primary symptom, belongs to " dysentery ", " having loose bowels " category in Chinese medicine, many diseases caused by exogenous pathogenic factor of cause of disease six climate exopathogens epidemic disease poison, internal injury diet seven emotions make spleen injury, the lifting imbalance, pure and impure mixed mutually, under the pressure of large intestine, make living damp and hot, the retardance QI and blood, blood loses the meat corruption, stops up to stagnate into pus, internal ulceration becomes infections, and take weakness of the spleen and stomach as this, damp-heat accumulation is mark, sick position is at spleen, stomach, large intestine, and is closely related with liver, kidney.The pathogenic characteristic of primary disease is deficiency in origin and excess in superficiality, coldheat complex, and simulataneous insufficiency and excessive, take insufficiency of the spleen as this, damp and hot for marking.
Insufficiency of the spleen is this pathogenetic pathologic basis.Li Dongyuan says: " abundance of vigour is all hindered also by the nothing of taste ".Spleen both decreased, and " can not transport, then QI and blood spirit is lost therefrom day, and the internal organs venation day is decreased therefrom, and therefore the muscle body day is cut.So tiredness with somnolence is arranged, myasthenia of limbs, shallow complexion, polyphagia with emaciation disappears and itches, the diease occurrence that generalized edema with distention of the chest and abdomen is let out dysentery is here "." bright doctor's fingers and palms spleen-stomach syndrome " points out " water paddy normally transporting absorbs for weakness of the spleen and stomach, failure of the spleen to transport and transform, and instead for wet, Gu Fanwei's water stagnates, and continues because of eating accumulation, produces the wet drink of expectorant heat and waits pathological change "." medical science must be read " one speech covers says " rush down all be formed in wet, wet all this in insufficiency of the spleen ".Insufficiency of the spleen resulting in production of dampness, domination of damp pathogen then turn can the impairment of the spleen.Red ripple unit heavily fortified point also point out " spleen soil powerhouse self energy wins wet, does not then rush down without wet, insufficiency of the spleen generally by congenital enjoy compose deficiency lose the day after tomorrow in addition support, tired, worry impairing spleen and falling ill, for a long time under disease and kidney can cause asthenia of both the spleen and kidney.
Damp is the main cause of disease of primary disease, likes dryly because of the spleen being adverse to dampness, and all drenching with rain paddled, and the sense mist reveals heat-damp in summer, occupies for a long time the heresy of humidity, and skin is subjected to cold-damp, all can make damp attack body.The easiest being stranded of the damp of six climate exopathogens held back the spleen sun, affects the transporting of spleen, gastrointestinal dysfunction, and water paddy is mixed mutually and descends, and clear QI being mixed up with turbid QI causes and has loose bowels.
Eating and drinking without temperance or eat unclean thing by mistake is given birth to damp and hotly as usually having a liking for the pungent delicious food savoury of food wine meat, making, and wet steaming is strongly fragrant, intestinal mechanism of qi retardance, coagulation of QI-blood turns to pus and blood and red white under the dysentery, also can injure taste because the attitude food is raw and cold usually, cause insufficiency of spleen-YANG, transporting mistake department, retention of water-damp in the body, conversion of dampness into cold, accumulate in the cold-damp, in the Kui Sai intestinal, internal organs gas is obstructed, stagnation of QI blood addiction turns to pus and blood, and red white under the dysentery.
Damaged by excess of seven emotions focuses on the liver spleen.Depressed rage impairing the liver, the liver failing to maintain the normal flow of QI, the horizontal soil of taking advantage of of wood, taste are restricted, dysfunction of the spleen in transportation and transformation, or it is depressed to be worried, dysfunction of the spleen, and water paddy difficultyization, retention of water-damp in the body, with the passing of time cementing, mechanism of qi is obstructed, and stagnation of QI blood is tired, can gradually become dysentery red white.
No matter " pathogen usually intruding into collateral in protracted disease " " the many stasis of bloods of prolonged illness " are that the damp and hot poison of diseases caused by exogenous pathogenic factor is evil, or interior impairing the liver spleen kidney, all have the blood stasis of blood to stagnate in the intestinal network, and mechanism of qi is stopped up resistance in the intestinal, turbid poison is stopped up stagnant, stagnation of QI-blood, and development of evil in febrile disease mistake department, blood stasis intestinal network, the fat network is impaired, corruption is turbid fights mutually, and blood loses the meat corruption, turns to pus and blood, and internal ulceration becomes infections.Just as saying in the Wang Qingren errors in Medicine Corrected: " the abdomen tripe is done to rush down, and person more of a specified duration must blood stasis be ", " have loose bowels with the passing of time, hundred sides are not imitated, and are that blood stasis is too much.
Theoretical based on above-mentioned Chinese traditional treatment, the present invention focuses on heat-clearing and toxic substances removing, invigorating the spleen and regulating the stomach, blood circulation promoting and blood stasis dispelling in treatment, propose a kind of Chinese medicine composition that is used for the treatment of chronic ulcerative colitis, its crude drug comprises Radix Rehmanniae Preparata, Caulis Polygoni Multiflori, Myrrha, Rhizoma Dioscoreae, Rhizoma Polygonati, Fructus Chebulae, Herba Asari, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Gentianae, Folium Isatidis, Rhizoma Wenyujin Concisum, Radix Vladimiriae, Fructus Viticis, Radix Salviae Miltiorrhizae, Polyporus, Pseudobulbus Bletillae (Rhizoma Bletillae), Galla Chinensis, the Rhizoma Pinelliae, Fructus Alpiniae Oxyphyllae, catechu, Rhizoma Saururi (Herba Saururi), Herba Senecionis Scandentis, Fructus Aristolochiae, Herba Polygoni cymosi.
Preferably, described Chinese medicine composition only is made of the above-mentioned raw materials medicine.
In the side, the Radix Rehmanniae Preparata sweet in the mouth is and warm in nature, and sweet Wen Zhirun is to nourish blood, wet perfume (or spice) is with promoting the circulation of blood, and invigorating middle warmer has row, in the row benefit is arranged, arrogate to oneself and blood system, enrich blood and invigorate blood circulation, reducing swelling and alleviating pain, blood-activating and qi-promoting, the Caulis Polygoni Multiflori gentle network that can nourish blood, relieving spasm to stop pain, treatment dysentery stomachache, Caulis Polygoni Multiflori has obvious inhibitory action to the acute inflammation edema, can suppress the hypertrophy of granuloma induced by implantation of cotton pellets, has preferably spasmolysis and analgesia effect, water decoction can make the cellular immune function that is in low state recover normal, the protection gastrointestinal mucosa is regulated the gastrointestinal function, and alleviates crampy gastrointestinal pain, Myrrha breaks stagnated blood, the removing heat from blood detumescence, removing the necrotic tissue and promoting granulation has the microcirculation of improvement, anticoagulant, antithrombotic forms, Antifungi, antiinflammatory, granulation promoting, the effects such as analgesia, Rhizoma Dioscoreae spleen reinforcing nourishing the stomach, the kidney invigorating arresting seminal emission contains allantoin in the composition, topical application can promote the healing of ulcer surface; Contained tannin has the effect of relieving diarrhea with astringents; Rhizoma Polygonati spleen invigorating QI invigorating; regulate body non-specific cell immunologic function; holder skin ulcer granulation promoting; promote the ulcer surface healing; prevention hyperplastic polyp or cicatrix excessively form; the Fructus Chebulae is sour and astringent; but relieving diarrhea with astringents dysentery; the sterilization skin ulcer; the all hot using warming therapy product of Herba Asari; but the kidney warming warms up spleen and helps the fortune cold relieving; the Radix Et Rhizoma Rhei purging heat and dredging bowels; removing pathogenic heat from blood and toxic substance from the body; eliminating blood stasis and inducing menstruation; can suppress IL-1; IL-6; IL-8; TNF; prostaglandin; the excessive generation of the inflammation factors such as endotoxin; Radix Pulsatillae bitter in the mouth is cold in nature; enter positive bright blood system; heat-clearing and toxic substances removing; eliminating pathogenic heat from blood to cure dysentery; Radix Gentianae; Folium Isatidis has obvious inhibitory action to various pathogens; can kill ameba and grow body; strengthen leukocyte and phagocytic function; effect with antiinflammatory and repairing ulcer; Rhizoma Wenyujin Concisum is invigorated blood circulation; circulation of qi promoting; the pain relieving promoting tissue regeneration and ulcer healing; the Radix Vladimiriae regulating qi-flowing for harmonizing stomach; the dehumidifying of being amusing; the Fructus Viticis dispersing the stagnated live-QI to relieve the stagnation of QI; the easing the affected liver emergency makes irritability be able to bar to reach; the Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling; promoting the circulation of blood is nourished blood and can be improved the blood circulation of gastrointestinal mucosa, promotes the reparation of mucosa, the Polyporus invigorating spleen to remove dampness; be apt to control again acute appendicitis; the Pseudobulbus Bletillae (Rhizoma Bletillae) astringing to arrest bleeding, promoting tissue regeneration and ulcer healing can promote the growth of intestinal mucosa wound surface granulation and healing; rotten to the corn to inflammation; ulcer has good sore effect; the Galla Chinensis relieving diarrhea with astringents; the detoxifcation sore, Rhizoma Pinelliae drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI; dissolving lump and resolving mass; can suppress gastric secretion and pepsin activity, reduce total acidity gastric juice and free acidity, acute mucosal lesion is had protection and promotes repair; to the indometacin type; pyloric ligation ulcers; chronic acetic acid type ulcer has significant preventive and therapeutic effect; the water logging stress ulcer is also had certain inhibitory action, and Fructus Alpiniae Oxyphyllae is warming spleen and stopping diarrha; the warming the kidney controlling nocturnal emission with astringent drugs, catechu removing dampness sore; hemostasia and promoting granulation; the Rhizoma Saururi (Herba Saururi) inducing diuresis to remove edema; heat-clearing and toxic substances removing; the Herba Senecionis Scandentis heat-clearing and toxic substances removing; control acute appendicitis, the Fructus Aristolochiae bowel relieving hemorrhoid that disappear, Herba Polygoni cymosi heat-clearing and toxic substances removing; inducing diuresis to remove edema; all medicines share, and play altogether heat-clearing and toxic substances removing; invigorating the spleen and regulating the stomach; the effect of blood circulation promoting and blood stasis dispelling.
Chinese medicine composition provided by the invention has the intestinal of improvement and mesenteric mesaraic microcirculation, increase blood flow, remove visceral smooth muscle spasm and infection, ischemia resisting anoxia, promote tissue repair and regeneration, promote conversion and the absorption of proliferative lesion, improve the multiple effects such as body's immunity.Particularly by improving this effect of microcirculation, improved local patholoic change blood fortune and histotrophic nutrition state, made inflammation local absorption, ulcer healing, thereby reach therapeutic purposes.
The pharmacology of each crude drug is as follows:
Radix Rehmanniae Preparata: have another name called Radix Rehmanniae Preparata, sweet in the mouth, slightly warm in nature enters liver, kidney channel, has the YIN nourishing of enriching blood, and beneficial essence is filled out the effect of marrow, is used for blood deficiency and yellow complexion; Dizzy, cardiopalmus, insomnia, menoxenia is collapsed more than; Hepatic and renal YIN deficiency, night sweat, sufficient knee joint pain, soreness of the waist and knees, Hiccough and deaf, the head is dim-sighted; The seminal emission sexual impotence; Infertility; Menoxenia; Metrostaxis; Early whitening of beard and hair; Quench one's thirst; Constipation; The cards such as dyspnea with rapid and short breath of suffering from a deficiency of the kidney.
Caulis Polygoni Multiflori: sweet in the mouth, little hardship, property is flat; GUIXIN, Liver Channel have the effect of energy tranquilizing by nourishing the heart, dispelling wind and removing obstruction in the collateral, cure mainly insomnia and dreamful sleep, blood deficiency general pain, numbness of the skin, rheumatic arthralgia, the cards such as wind skin ulcer scabies.
Myrrha: latin name Myrrha, bitter in the mouth, suffering, property is flat, enters liver, spleen, the heart, kidney channel, and the effect of promoting blood circulation and stopping pain, detumescence and promoting granulation is arranged, and cures mainly the cards such as breast abdomen stasis of blood pain, dysmenorrhea, amenorrhea, lump in the abdomen, traumatic injury, carbuncle skin infection, acute appendicitis, conjunctival congestion and swelling pain.
Rhizoma Dioscoreae: latin name Dioscoreae Rhizoma, sweet in the mouth, property is put down, enter lung, spleen, kidney channel, have strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help that the five internal organs, bone and muscle strengthening, long will are calmed the nerves, the effect of life lengthening, cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity are weak, the red card such as swollen, fat of the frequent micturition of quenching one's thirst, the premature ejaculation of passing out semen, leukorrhagia nebulousurine, skin.
Rhizoma Polygonati: latin name Polygonati Rhizoma, sweet in the mouth, property is flat, enter lung, spleen, kidney channel, has the yin nourishing of fostering the spirit of nobility, spleen invigorating lung moistening, the effect of enriching kidney essence, be used for the taste deficiency of qi and yin, lack of appetite is unable, lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, quenching one's thirst of yin asthenia generating intrinsic heat, the cards such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.
The Fructus Chebulae: latin name Chebulae Fructus, sour in the mouth, puckery, property is flat, returns lung, and large intestine channel has relieving diarrhea with astringents, astringing lung-QI and relieving cough, the effect of pathogenic fire reducing sore-throat relieving is used for the chronic diarrhea chronic dysentery, the proctoptosis of having blood in stool, cough and asthma due to lung deficiency, chronic cough is more than, the cards such as pharyngalgia hoarseness.
Herba Asari: latin name Asari Radix et Rhizoma, acrid in the mouth, warm in nature, return lung, kidney channel, have the expelling wind and cold pain relieving, the effect that warming the lung to resolve fluid-retention is sensible, cure mainly affection of exogenous wind-cold, headache, toothache, wind and cold temperature numbness, affection of exogenous wind-cold, in stop lung cold cough with asthma due to the cold fluid-retention, nasal obstruction nasal sinusitis, wind-eye corneal nebula, the deafness pharyngalgia, the cards such as aphtha halitosis, Herba Asari has expelling wind and cold, the sensible effect of warming the lung, has the effect of antihistamine antiallergic action, can reduce the release of Anaphylactic mediator, thereby suppress the activation of the expression suppressor T cell of IL-2 receptor.
Radix Et Rhizoma Rhei: latin name Rhei Radix et Rhizoma, bitter in the mouth, cold in nature, return the stomach warp; Large intestine channel; Liver Channel; Spleen channel, have attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; The effect of detoxifcation cures mainly the excess-heat constipation; The accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhea; The edema abdominal distention; Dysuria; Conjunctival congestion; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Gastropyretic vomiting; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Blood-retention; Amenorrhea; The stasis of blood stagnated and suffered from abdominal pain puerperal; Lump in the abdomen; Traumatic injury; Pyretic toxicity carbuncle and ulcer; Erysipelas; The cards such as scald.
The Radix Pulsatillae: bitter in the mouth, cold in nature, enter stomach, large intestine channel, the effect of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery is arranged, be mainly used in the intestines and stomach damp and hot stagnant heating stomachache, dysentery pus and blood, the treatment of the symptoms such as tenesmus are arranged, hematodiarrhoea hematochezia effect to the large intestine heat in blood is better, and the Radix Pulsatillae all has certain inhibitory action to dysentery bacterium, Bacillus typhi, bacillus subtilis, escherichia coli, Staphyloccocus aureus.
Radix Gentianae: latin name Gentianae Radix et Rhizoma, bitter in the mouth, cold in nature, return liver, gallbladder meridian, have the effect of heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire, cure mainly jaundice due to damp-heat, swelling of the vulva pudendal pruritus, leukorrhagia, eczema pruritus, liver-fire conjunctival congestion, Hiccough and deaf, hypochondriac pain bitter taste, persistent erection of the penis, the cards such as convulsion with spasms.Cortex Lycii: latin name Lycii Cortex, cold in nature, sweet in the mouth has removing heat from blood except steaming, and the effect of lung heat clearing pathogenic fire reducing cures mainly the cards such as deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, cough due to lung-heat, spitting of blood, epistaxis.
Folium Isatidis: latin name Isatidis Folium, bitter in the mouth, property Great Cold, GUIXIN, liver, gallbladder, stomach warp have antipyretic and detoxicated, cooling blood and dissolving purpura, the effect of jaundice eliminating, the excess-heat that can clearing heat in QI system divides, can separate again the pyretic toxicity of blood system, the high febrile perspiration that is mainly used in due to the pestilence calentura goes out the excessive thirst taking fluids profusely; The speckle of sending out that fire-toxin is flourishing is gone mad the symptoms such as haematemesis; The unconsciousness due to high fever of measles, the rash color is purple dark; Dampness-heat in the liver and gallbladder is accumulate the jaundice of steaming; The deafness and tinnitus of liver and gall fire liter; The cards such as the pharyngalgia due to the fire stagnation pyretic toxicity, aphtha of the mouth and tongue, hepatitis.
Rhizoma Wenyujin Concisum: latin name Rhizoma Wenyujin Concisum, acrid in the mouth, hardship, warm in nature, return liver, spleen channel, have the removing blood stasis circulation of qi promoting, the effect of inducing menstruation to relieve menalgia cures mainly amenorrhea due to stagnation of blood, menalgia, the breast side of body twinges, rheumatic arthralgia, shoulder arm pain, the cards such as injury from falling down.
Radix Vladimiriae: latin name Radix Dolomiaeae, warm in nature, acrid in the mouth, hardship are returned spleen, stomach, large intestine, gallbladder meridian, have promoting the circulation of QI to relieve pain, the stomach function regulating relieving distension, the effect of antidiarrheal cures mainly the cards such as abdominal swelling, inappetence, stomachache, dysentery tenesmus.
Fructus Viticis: acrid in the mouth, hardship, cold nature is returned bladder, liver, stomach warp, has dispelling wind and heat pathogens, and the clear sharp head's effect cures mainly anemopyretic cold headache, gingivitis, the many tears of conjunctival congestion, poor vision, the card such as have a dizzy spell.
Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature, GUIXIN, Liver Channel have promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, the removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, the effect of nourishing blood to tranquillize the mind cures mainly menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, the cards such as angina pectoris.
Polyporus: sweet in the mouth, light, property is flat, enters kidney, urinary bladder channel, has the effect of promoting diuresis to eliminate damp pathogen, is mainly used in the edema of retention of water-damp, dysuria, and the having loose bowels, vomit of stagnation of dampness due to deficiency of the spleen; The cards such as the leucorrhea of damp invasion of lower energizer, nebulousurine.
Pseudobulbus Bletillae (Rhizoma Bletillae): latin name Bletillac Rhizoma, bitter in the mouth, sweet, puckery, cold nature is returned lung, liver, stomach warp; have the tonifying the lung hemostasis, detumescence and promoting granulation, the effect of sore cures mainly lung and hinders hemoptysis; epistaxis, incised wound is hemorrhage, swollen ulcer drug; ulcer pain, the soup fire is burnt, the cards such as rhagadia manus et pedis; Pseudobulbus Bletillae (Rhizoma Bletillae) includes Rhizoma Bletillae gel, can make leukocyte recruitment, forms artificial thrombosis; reach the effect of rapid hemostasis, the phlegmatic temperament that Pseudobulbus Bletillae (Rhizoma Bletillae) contains can cover form thin film at wound surface and reach hemorrhage of protection and stop blooding.
Galla Chinensis: latin name Galla Chinensis, sour in the mouth, puckery, cold in nature, return lung, large intestine, kidney channel, have the effect of astringent or styptic treatment for spontaneous sweating, the supplementing QI for promoting the production of body fluid of convergence, kidney calming, cure mainly: chronic cough of deficiency lung; Spontaneous sweating; The chronic dysentery chronic diarrhea; Proctoptosis; Seminal emission; Nebulousurine; Various hemorrhage; The cards such as carbuncle furuncle, Galla Chinensis energy enhancing body can strengthen the immunologic function of cell to the defence capability of nonspecific stimulation, and this pathogenic bacterium are had inhibitory action, and can the antiviral growth.
The Rhizoma Pinelliae: latin name Pinellia Tuber, acrid in the mouth, warm in nature, enter spleen, stomach warp, have drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the effect of dissolving lump and resolving mass, the hot loose warm-dryness syndrome of this product is poisonous, mainly enters that taste are double to enter lung, the water of manageing it is wet, lowering the adverse flow of QI, and the kind taste damp-phlegm of dispelling, water is wet to go then the strong and sputum of spleen from disappearing, contrary gas harmonization of the stomach falls then and the feeling of fullness vomiting from ending, so be drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the good medicine of dissolving lump and resolving mass, be used for the abundant expectoration cough, breast gastral cavity painful abdominal mass is vexed, the thoracic obstruction, blocked-up chest, goiter scrofula, skin infection swell and ache, globus hystericus, the cards such as adverse rising of stomach-QI, nausea and vomiting.
Fructus Alpiniae Oxyphyllae: acrid in the mouth, warm in nature, return spleen, kidney channel, have warming the kidney controlling nocturnal emission with astringent drugs reducing urination, the warming spleen and stopping diarrha effect of taking the photograph saliva cures mainly enuresis due to deficiency of the kidney, frequent micturition, the seminal emission nebulousurine, spleen-cold syndrome is had loose bowels, the effect of cold type of pain in the abdomen.
Catechu: bitter in the mouth, puckery, cold nature is returned lung meridian, has the effect of removing dampness promoting tissue regeneration and ulcer healing, is used for ulcer being unable to heal, eczema, aphtha is fallen cards such as pouncing on the pain of injury, traumatic hemorrhage.
Rhizoma Saururi (Herba Saururi): latin name Saururi Herba, sweet in the mouth, suffering, cold in nature, return lung, urinary bladder channel, have clearing away heat and promoting diuresis; The effect of removing toxic substances and promoting subsidence of swelling cures mainly pyretic stranguria; Stranguria with blood; Edema; Foot gas; Jaundice; Dysentery; Leukorrhagia; Carbuncle sore tumefacting virus; Eczema; The cards such as venom.
Herba Senecionis Scandentis: latin name Senecionis Scandentis Hebra, cold in nature, bitter in the mouth is returned lung, Liver Channel, has heat-clearing and toxic substances removing, an effect of the dampness removing that makes eye bright, and has the cards such as carbuncle sore tumefacting virus, cold, fever, conjunctival congestion and swelling pain, dysentery, skin eczema.
Fructus Aristolochiae: latin name Fructus Aristolochiae, bitter in the mouth, cold nature is returned lung, large intestine channel, has the lung heat clearing sending down the abnormal ascending QI, relieving cough and asthma, the disappear effect of hemorrhoid of bowel relieving is used for dyspnea and cough due to lung-heat, sputum mixed with blood, the hot hemorrhoidal bleeding of intestinal, the cards such as swelling and pain of hemorrhoid.
Herba Polygoni cymosi: sour in the mouth, cold nature is returned lung, urinary bladder channel, has the effect of heat-clearing and toxic substances removing, inducing diuresis to remove edema, cough-relieving, cures mainly laryngopharynx swelling and pain, cough due to lung-heat, children's's pertussis, edema oliguria, damp-heat dysentery, the cards such as eczema.
The weight portion of described each crude drug of Chinese medicine composition is respectively Radix Rehmanniae Preparata 33 weight portions ~ 43 weight portions, Caulis Polygoni Multiflori 27 weight portions ~ 37 weight portions, Myrrha 16 weight portions ~ 26 weight portions, Rhizoma Dioscoreae 41 weight portions ~ 51 weight portions, Rhizoma Polygonati 36 weight portions ~ 46 weight portions, Fructus Chebulae's 20 weight portions ~ 30 weight portions, Herba Asari 13 weight portions ~ 23 weight portions, Radix Et Rhizoma Rhei 22 weight portions ~ 32 weight portions, the Radix Pulsatillae 51 weight portions ~ 61 weight portions, Radix Gentianae 35 weight portions ~ 45 weight portions, Folium Isatidis 72 weight portions ~ 82 weight portions, Rhizoma Wenyujin Concisum 28 weight portions ~ 38 weight portions, Radix Vladimiriae 12 weight portions ~ 22 weight portions, Fructus Viticis 19 weight portions ~ 29 weight portions, Radix Salviae Miltiorrhizae 31 weight portions ~ 41 weight portions, Polyporus 29 weight portions ~ 39 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 30 weight portions ~ 40 weight portions, Galla Chinensis 25 weight portions ~ 35 weight portions, the Rhizoma Pinelliae 21 weight portions ~ 31 weight portions, Fructus Alpiniae Oxyphyllae 34 weight portions ~ 44 weight portions, catechu 16 weight portions ~ 26 weight portions, Rhizoma Saururi (Herba Saururi) 41 weight portions ~ 51 weight portions, Herba Senecionis Scandentis 22 weight portions ~ 32 weight portions, Fructus Aristolochiae 19 weight portions ~ 29 weight portions, Herba Polygoni cymosi 27 weight portions ~ 37 weight portions.
The weight portion of described each crude drug of Chinese medicine composition further preferably is respectively Radix Rehmanniae Preparata 35 weight portions ~ 41 weight portions, Caulis Polygoni Multiflori 29 weight portions ~ 35 weight portions, Myrrha 18 weight portions ~ 24 weight portions, Rhizoma Dioscoreae 43 weight portions ~ 49 weight portions, Rhizoma Polygonati 38 weight portions ~ 44 weight portions, Fructus Chebulae's 22 weight portions ~ 28 weight portions, Herba Asari 15 weight portions ~ 21 weight portions, Radix Et Rhizoma Rhei 24 weight portions ~ 30 weight portions, the Radix Pulsatillae 53 weight portions ~ 59 weight portions, Radix Gentianae 37 weight portions ~ 43 weight portions, Folium Isatidis 74 weight portions ~ 80 weight portions, Rhizoma Wenyujin Concisum 30 weight portions ~ 36 weight portions, Radix Vladimiriae 14 weight portions ~ 20 weight portions, Fructus Viticis 21 weight portions ~ 27 weight portions, Radix Salviae Miltiorrhizae 33 weight portions ~ 39 weight portions, Polyporus 31 weight portions ~ 37 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 32 weight portions ~ 38 weight portions, Galla Chinensis 27 weight portions ~ 33 weight portions, the Rhizoma Pinelliae 23 weight portions ~ 29 weight portions, Fructus Alpiniae Oxyphyllae 36 weight portions ~ 42 weight portions, catechu 18 weight portions ~ 24 weight portions, Rhizoma Saururi (Herba Saururi) 43 weight portions ~ 49 weight portions, Herba Senecionis Scandentis 24 weight portions ~ 30 weight portions, Fructus Aristolochiae 21 weight portions ~ 27 weight portions, Herba Polygoni cymosi 29 weight portions ~ 35 weight portions.
The weight portion of described each crude drug of Chinese medicine composition most preferably is respectively Radix Rehmanniae Preparata 38 weight portions, Caulis Polygoni Multiflori 32 weight portions, Myrrha 21 weight portions, Rhizoma Dioscoreae 46 weight portions, Rhizoma Polygonati 41 weight portions, Fructus Chebulae's 25 weight portions, Herba Asari 18 weight portions, Radix Et Rhizoma Rhei 27 weight portions, the Radix Pulsatillae 56 weight portions, Radix Gentianae 40 weight portions, Folium Isatidis 77 weight portions, Rhizoma Wenyujin Concisum 33 weight portions, Radix Vladimiriae 17 weight portions, Fructus Viticis 24 weight portions, Radix Salviae Miltiorrhizae 36 weight portions, Polyporus 34 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 35 weight portions, Galla Chinensis 30 weight portions, the Rhizoma Pinelliae 26 weight portions, Fructus Alpiniae Oxyphyllae 39 weight portions, catechu 21 weight portions, Rhizoma Saururi (Herba Saururi) 46 weight portions, Herba Senecionis Scandentis 27 weight portions, Fructus Aristolochiae 24 weight portions, Herba Polygoni cymosi 32 weight portions.
Chinese medicine composition provided by the invention is oral drugs, and its dosage form can for powder, granule, oral liquid, pill, capsule, tablet etc., be preferably granule and powder.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, is specially:
The first step, with the Radix Pulsatillae, Radix Gentianae, Folium Isatidis, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Saururi (Herba Saururi), Herba Senecionis Scandentis and Herba Polygoni cymosi are pulverized, be mixed in proportion, obtain mixture, the adding determining alcohol is 70% ~ 80% the even moistening of ethanol, the mass ratio of mixture and ethanol is 1:1 ~ 1:2, and airtight placement 12h ~ 18h drops in the percolate pot, continue to add determining alcohol with respect to 2 ~ 4 times of mixture qualities and be 70% ~ 80% ethanol, continue dipping 6h ~ 12h, percolation, flow are per minute 5 ~ 7ml, collect percolate, to filter, filtrate is-0.06 at pressure~-0.04MPa, temperature is that concentrating under reduced pressure becomes the extractum of 65 ℃ of relative densities 1.15 ~ 1.20 under 65 ℃ of conditions;
Second step, with macroporous resin adsorption on the extractum, the quality of extractum and the mass ratio of macroporous adsorbent resin are 1:1 ~ 2, use first the water elution with respect to 0.3 ~ 0.5 times of the quality of macroporous adsorbent resin, using determining alcohol with respect to 4 ~ 6 times of the quality of macroporous adsorbent resin is 60% ~ 80% ethanol elution again, collects eluent, the concentrating under reduced pressure desolventizing, obtain and get dry extract, be ground into fine powder;
The 3rd step, remaining component is pulverized, be mixed in proportion, obtain mixture, decoct with water 3 times, the 1st amount of water is 8 times of mixture quality, decocts 2h, the 2nd time and the 3rd amount of water are 6 times of mixture quality, decoction liquor after each the decoction is all filtered, and merges filtrate, adds determining alcohol and is 70%~80% ethanol to alcohol volume content and reach 50%~60%, hold over night, again filter, filtrate be-0.08 at pressure~-0.06MPa, temperature are under 75 ℃ of conditions, concentrate desolventizing, obtain and get dry extract, be ground into fine powder;
In the 4th step, the fine powder and the 3rd that second step is obtained goes on foot the fine powder mixing that obtains, and spray drying according to needed dosage form, according to the conventional preparation method of each dosage form, is prepared into powder, granule, oral liquid, pill, capsule, tablet.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is granule, is specially:
The first step, with the Radix Pulsatillae, Radix Gentianae, Folium Isatidis, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Saururi (Herba Saururi), Herba Senecionis Scandentis and Herba Polygoni cymosi are pulverized, be mixed in proportion, obtain mixture, the adding determining alcohol is 70% ~ 80% the even moistening of ethanol, the mass ratio of mixture and ethanol is 1: 1 ~ 1:2, and airtight placement 12h ~ 18h drops in the percolate pot, continue to add determining alcohol with respect to 2 ~ 4 times of mixture qualities and be 70% ~ 80% ethanol, continue dipping 6h ~ 12h, percolation, flow are per minute 5 ~ 7ml, collect percolate, to filter, filtrate is-0.06 at pressure~-0.04MPa, temperature is that concentrating under reduced pressure becomes the extractum of 65 ℃ of relative densities 1.15 ~ 1.20 under 65 ℃ of conditions;
Second step, with macroporous resin adsorption on the extractum, the quality of extractum and the mass ratio of macroporous adsorbent resin are 1:1 ~ 2, use first the water elution with respect to 0.3 ~ 0.5 times of the quality of macroporous adsorbent resin, using determining alcohol with respect to 4 ~ 6 times of the quality of macroporous adsorbent resin is 60% ~ 80% ethanol elution again, collects eluent, the concentrating under reduced pressure desolventizing, obtain and get dry extract, be ground into fine powder;
The 3rd step, remaining component is pulverized, be mixed in proportion, obtain mixture, decoct with water 3 times, the 1st amount of water is 8 times of mixture quality, decocts 2h, the 2nd time and the 3rd amount of water are 6 times of mixture quality, decoction liquor after each the decoction is all filtered, and merges filtrate, adds determining alcohol and is 70%~80% ethanol to alcohol volume content and reach 50%~60%, hold over night, again filter, filtrate be-0.08 at pressure~-0.06MPa, temperature are under 75 ℃ of conditions, concentrate desolventizing, obtain and get dry extract, be ground into fine powder;
In the 4th step, the fine powder and the 3rd that second step is obtained goes on foot the fine powder mixing that obtains, spray drying, and adding determining alcohol is 75% ~ 85% ethanol soft material processed, granulate with oscillating granulator, oven dry under 60 ℃, granulate gets medicinal granule of the present invention.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is powder, is specially:
The first step, with the Radix Pulsatillae, Radix Gentianae, Folium Isatidis, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Saururi (Herba Saururi), Herba Senecionis Scandentis and Herba Polygoni cymosi are pulverized, be mixed in proportion, obtain mixture, the adding determining alcohol is 70% ~ 80% the even moistening of ethanol, the mass ratio of mixture and ethanol is 1: 1 ~ 1:2, and airtight placement 12h ~ 18h drops in the percolate pot, continue to add determining alcohol with respect to 2 ~ 4 times of mixture qualities and be 70% ~ 80% ethanol, continue dipping 6h ~ 12h, percolation, flow are per minute 5 ~ 7ml, collect percolate, to filter, filtrate is-0.06 at pressure~-0.04MPa, temperature is that concentrating under reduced pressure becomes the extractum of 65 ℃ of relative densities 1.15 ~ 1.20 under 65 ℃ of conditions;
Second step, with macroporous resin adsorption on the extractum, the quality of extractum and the mass ratio of macroporous adsorbent resin are 1:1 ~ 2, use first the water elution with respect to 0.3 ~ 0.5 times of the quality of macroporous adsorbent resin, using determining alcohol with respect to 4 ~ 6 times of the quality of macroporous adsorbent resin is 60% ~ 80% ethanol elution again, collects eluent, the concentrating under reduced pressure desolventizing, obtain and get dry extract, be ground into fine powder;
The 3rd step, remaining component is pulverized, be mixed in proportion, obtain mixture, decoct with water 3 times, the 1st amount of water is 8 times of mixture quality, decocts 2h, the 2nd time and the 3rd amount of water are 6 times of mixture quality, decoction liquor after each the decoction is all filtered, and merges filtrate, adds determining alcohol and is 70%~80% ethanol to alcohol volume content and reach 50%~60%, hold over night, again filter, filtrate be-0.08 at pressure~-0.06MPa, temperature are under 75 ℃ of conditions, concentrate desolventizing, obtain and get dry extract, be ground into fine powder;
In the 4th step, the fine powder and the 3rd that second step is obtained goes on foot the fine powder mixing that obtains, and spray drying obtains powder.
The present invention also provide above-mentioned Chinese medicine composition for the preparation of the treatment chronic ulcerative colitis medicine in application.
Below adopt embodiment to describe embodiments of the present invention in detail, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can fully understand and implements according to this.
The concrete preparation of embodiment 1 granule 1
With Radix Pulsatillae 56g; Radix Gentianae 40g; Folium Isatidis 77g; Pseudobulbus Bletillae (Rhizoma Bletillae) 35g; Rhizoma Saururi (Herba Saururi) 46g; Herba Senecionis Scandentis 27g and Herba Polygoni cymosi 32g pulverize; mix; obtain mixture; adding 350g determining alcohol is 80% the even moistening of ethanol; airtight placement 15h; drop in the percolate pot; the determining alcohol that continues adding 900g is 80% ethanol; continue dipping 12h; percolation; flow is per minute 6ml; collect percolate; filter; filtrate at pressure is-0.06MPa; temperature is under 65 ℃ of conditions; concentrating under reduced pressure becomes the extractum of 65 ℃ of relative densities 1.20; with D101 type macroporous resin adsorption on the extractum; the quality of extractum and the mass ratio of macroporous adsorbent resin are 1:1; use first the water elution with respect to 0.4 times of the quality of macroporous adsorbent resin; using determining alcohol with respect to 5 times of the quality of macroporous adsorbent resin is 70% ethanol elution again; collect eluent; the concentrating under reduced pressure desolventizing; obtain and get dry extract; be ground into fine powder; with Radix Rehmanniae Preparata 38g; Caulis Polygoni Multiflori 32g; Myrrha 21g; Rhizoma Dioscoreae 46g; Rhizoma Polygonati 41g; Fructus Chebulae 25g; Herba Asari 18g; Radix Et Rhizoma Rhei 27g; Rhizoma Wenyujin Concisum 33g; Radix Vladimiriae 17g; Fructus Viticis 24g; Radix Salviae Miltiorrhizae 36g; Polyporus 34g; Galla Chinensis 30g; Rhizoma Pinelliae 26g; Fructus Alpiniae Oxyphyllae 39g; catechu 21g; Fructus Aristolochiae 24g pulverizes; mix; obtain mixture; decoct with water 3 times; the 1st time amount of water is 4.3kg, decocts 2h, and the 2nd time and the 3rd amount of water are 3.2kg; decoction liquor after each the decoction is all filtered; merge filtrate, add determining alcohol and be 80% ethanol to alcohol volume content and reach 50%, hold over night; again filter; with filtrate at pressure be-0.08MPa; temperature is under 75 ℃ of conditions, concentrates desolventizing, obtains to get dry extract; be ground into fine powder; the fine powder that obtains is previously mixed, spray drying, adding determining alcohol is 75% ethanol soft material processed; granulate with oscillating granulator; 60 ℃ of lower oven dry, granulate gets granule; splitting claims dress, every bag of 10g.
The concrete preparation of embodiment 2 granules 2
With Radix Pulsatillae 53g; Radix Gentianae 37g; Folium Isatidis 74g; Pseudobulbus Bletillae (Rhizoma Bletillae) 32g; Rhizoma Saururi (Herba Saururi) 43g; Herba Senecionis Scandentis 24g and Herba Polygoni cymosi 29g pulverize; mix; obtain mixture; adding 300g determining alcohol is 80% the even moistening of ethanol; airtight placement 15h; drop in the percolate pot; the determining alcohol that continues adding 900g is 80% ethanol; continue dipping 12h; percolation; flow is per minute 6ml; collect percolate; filter; filtrate at pressure is-0.06MPa; temperature is under 65 ℃ of conditions; concentrating under reduced pressure becomes the extractum of 65 ℃ of relative densities 1.20; with D101 type macroporous resin adsorption on the extractum; the quality of extractum and the mass ratio of macroporous adsorbent resin are 1:1; use first the water elution with respect to 0.4 times of the quality of macroporous adsorbent resin; using determining alcohol with respect to 5 times of the quality of macroporous adsorbent resin is 75% ethanol elution again; collect eluent; the concentrating under reduced pressure desolventizing; obtain and get dry extract; be ground into fine powder; with Radix Rehmanniae Preparata 35g; Caulis Polygoni Multiflori 29g; Myrrha 18g; Rhizoma Dioscoreae 43g; Rhizoma Polygonati 38g; Fructus Chebulae 22g; Herba Asari 15g; Radix Et Rhizoma Rhei 24g; Rhizoma Wenyujin Concisum 30g; Radix Vladimiriae 14g; Fructus Viticis 21g; Radix Salviae Miltiorrhizae 33g; Polyporus 31g; Galla Chinensis 27g; Rhizoma Pinelliae 23g; Fructus Alpiniae Oxyphyllae 36g; catechu 18g; Fructus Aristolochiae 21g pulverizes; mix; obtain mixture; decoct with water 3 times; the 1st time amount of water is 3.8kg, decocts 2h, and the 2nd time and the 3rd amount of water are 2.9kg; decoction liquor after each the decoction is all filtered; merge filtrate, add determining alcohol and be 80% ethanol to alcohol volume content and reach 50%, hold over night; again filter; with filtrate at pressure be-0.08MPa; temperature is under 75 ℃ of conditions, concentrates desolventizing, obtains to get dry extract; be ground into fine powder; the fine powder that obtains is previously mixed, spray drying, adding determining alcohol is 75% ethanol soft material processed; granulate with oscillating granulator; 60 ℃ of lower oven dry, granulate gets granule; splitting claims dress, every bag of 10g.
The concrete preparation of embodiment 3 granules 3
With Radix Pulsatillae 59g; Radix Gentianae 43g; Folium Isatidis 80g; Pseudobulbus Bletillae (Rhizoma Bletillae) 38g; Rhizoma Saururi (Herba Saururi) 49g; Herba Senecionis Scandentis 30g and Herba Polygoni cymosi 35g pulverize; mix; obtain mixture; adding 350g determining alcohol is 80% the even moistening of ethanol; airtight placement 15h; drop in the percolate pot; the determining alcohol that continues adding 900g is 80% ethanol; continue dipping 12h; percolation; flow is per minute 6ml; collect percolate; filter; filtrate at pressure is-0.06MPa; temperature is under 65 ℃ of conditions; concentrating under reduced pressure becomes the extractum of 65 ℃ of relative densities 1.20; with D101 type macroporous resin adsorption on the extractum; the quality of extractum and the mass ratio of macroporous adsorbent resin are 1:1; use first the water elution with respect to 0.4 times of the quality of macroporous adsorbent resin; using determining alcohol with respect to 5 times of the quality of macroporous adsorbent resin is 75% ethanol elution again; collect eluent; the concentrating under reduced pressure desolventizing; obtain and get dry extract; be ground into fine powder; with Radix Rehmanniae Preparata 41g; Caulis Polygoni Multiflori 35g; Myrrha 24g; Rhizoma Dioscoreae 49g; Rhizoma Polygonati 44g; Fructus Chebulae 28g; Herba Asari 21g; Radix Et Rhizoma Rhei 30g; Rhizoma Wenyujin Concisum 36g; Radix Vladimiriae 20g; Fructus Viticis 27g; Radix Salviae Miltiorrhizae 39g; Polyporus 37g; Galla Chinensis 33g; Rhizoma Pinelliae 29g; Fructus Alpiniae Oxyphyllae 42g; catechu 24g; Fructus Aristolochiae 27g pulverizes; mix; obtain mixture; decoct with water 3 times; the 1st time amount of water is 3.8kg, decocts 2h, and the 2nd time and the 3rd amount of water are 2.9kg; decoction liquor after each the decoction is all filtered; merge filtrate, add determining alcohol and be 80% ethanol to alcohol volume content and reach 50%, hold over night; again filter; with filtrate at pressure be-0.08MPa; temperature is under 75 ℃ of conditions, concentrates desolventizing, obtains to get dry extract; be ground into fine powder; the fine powder that obtains is previously mixed, spray drying, adding determining alcohol is 75% ethanol soft material processed; granulate with oscillating granulator; 60 ℃ of lower oven dry, granulate gets granule; splitting claims dress, every bag of 10g.
The concrete preparation of embodiment 4 powders 1
With Radix Pulsatillae 56g, Radix Gentianae 40g, Folium Isatidis 77g, Pseudobulbus Bletillae (Rhizoma Bletillae) 35g, Rhizoma Saururi (Herba Saururi) 46g, Herba Senecionis Scandentis 27g and Herba Polygoni cymosi 32g pulverize, mix, obtain mixture, adding 350g determining alcohol is 80% the even moistening of ethanol, airtight placement 15h, drop in the percolate pot, the determining alcohol that continues adding 900g is 80% ethanol, continue dipping 12h, percolation, flow is per minute 6ml, collect percolate, filter, filtrate at pressure is-0.06MPa, temperature is under 65 ℃ of conditions, concentrating under reduced pressure becomes the extractum of 65 ℃ of relative densities 1.20, with D101 type macroporous resin adsorption on the extractum, the quality of extractum and the mass ratio of macroporous adsorbent resin are 1:1, use first the water elution with respect to 0.4 times of the quality of macroporous adsorbent resin, using determining alcohol with respect to 5 times of the quality of macroporous adsorbent resin is 70% ethanol elution again, collect eluent, the concentrating under reduced pressure desolventizing, obtain and get dry extract, be ground into fine powder, with Radix Rehmanniae Preparata 38g, Caulis Polygoni Multiflori 32g, Myrrha 21g, Rhizoma Dioscoreae 46g, Rhizoma Polygonati 41g, Fructus Chebulae 25g, Herba Asari 18g, Radix Et Rhizoma Rhei 27g, Rhizoma Wenyujin Concisum 33g, Radix Vladimiriae 17g, Fructus Viticis 24g, Radix Salviae Miltiorrhizae 36g, Polyporus 34g, Galla Chinensis 30g, Rhizoma Pinelliae 26g, Fructus Alpiniae Oxyphyllae 39g, catechu 21g, Fructus Aristolochiae 24g pulverizes, mix, obtain mixture, decoct with water 3 times, the 1st time amount of water is 4.3kg, decoct 2h, the 2nd time and the 3rd amount of water are 3.2kg, and the decoction liquor after each the decoction is all filtered, and merges filtrate, add determining alcohol and be 80% ethanol to alcohol volume content and reach 50%, hold over night is filtered again, with filtrate at pressure is-0.08MPa, temperature is under 75 ℃ of conditions, concentrated desolventizing, obtain and get dry extract, be ground into fine powder, the fine powder that obtains is previously mixed, spray drying obtains powder.
Embodiment 5 acute toxicity testings
Kunming mouse, 20 (SPF level), male and female half and half, 20 ± 2g is provided by Qingdao City's laboratory animal and zoopery center, and raising temperature is 25 ± 1 ℃, and experimental session freely obtains water and food, and illumination, dark 12h are alternately.
After detecting mice fasting 12h, gavage the granule 1 of the embodiment of the invention 1 preparation, concrete gavage method is for to be dissolved in granule in the distilled water, obtaining crude drug concentration is the solution of 4g/ml, gavages mice, mice day the gavage amount be 120g crude drug/kg, be adult's (60Kg) consumption per day (240 times of 0.5g crude drug/Kg), the administration secondary, the time is respectively at 9 o'clock in the morning and at 5 o'clock in afternoon, and the 24h mice begins feed after the first administration.The tight reaction of observing mice after the administration, and activity, gait, the feed, two of observing day by day mice just wait situation, record dead animal number was observed 7 altogether.
After the administration in the 24h mice spirit slightly poor, crispatura one, movable than slightly reducing before the administration, two just occur obviously unusual.Mice is movable after the feed recovers, gait freely, hair color is glossy.Body weight is without unusually changing and having no animal dead in the administration 7 days.
Embodiment 6 animal experimental datas
Laboratory animal
40 of healthy kunming mices, male and female half and half, weight 20 ± 2g is provided by Qingdao City's laboratory animal and zoopery center.
Medicine and reagent
The Chinese medicinal composition granules 1 of the embodiment of the invention 1 preparation is dissolved in it in distilled water, is mixed with the solution that crude drug concentration is 5g/ml; Dextran sulfate sodium (DSS), Zhong Hai Pharmaceutical Technology Co., Ltd in Jinan provides, and is dissolved in the solution for standby that distilled water is mixed with 30g/L; Sulfasalazine (SASP), Shanghai Xinyi Jiahua Pharmaceutical Co., Ltd. produces, and grinds 100 mesh sieves, and the suspension that is mixed with 0.025g/ml with distilled water is for subsequent use; TNF-α and IL-10 enzyme-linked immunosorbent assay (ELISA) test kit, the rich neoplasm technology company limited in Qingdao provides; The test kit of occulting blood, the precious careless Chinese medicine in Beijing technology development center provides.
Modeling and grouping
40 kunming mices adopt the table of random number method to be divided into blank group, model control group, SASP group and treatment by Chinese herbs group, 10 every group, male and female half and half.Each organizes the contrast of Mice Body quality, difference not statistically significant (P>0.05).
Except the blank group, mice is freely drunk 30g/L DSS solution 10d, gives simultaneously normal diet and feeds, and the blank group freely supplies the drink tap water.Observe every day such as mice stool character, diet, hair, active state etc., survey the Mice Body quality next day of from the modeling, find that stool is surveyed by the next day shown in the test kit from obviously changing to occult blood.With animal loose stool appears, any one standard as the modeling success in the positive of occulting blood or the naked eyes hemafecia.
Respectively organize mice before the modeling and all be quick on the draw, the happiness activity, hair color is pure white glossy, initiatively looks for food; The feces quality is harder, and crineous is the elliposoidal granule; The fecal occult blood experiment is all negative.The phenomenons such as after the modeling, except the blank group, each treated animal engendered in experiment on the 5th day becomes thin, and autonomic activities reduces, and happiness flocks together, and lazy moving, the delay of response of loss of appetite, asthenia, hogback, perpendicular hair, fur are not bright and clean; Feces is soft, shapeless loose stool or mucus bloody purulent stool, color is more shallow, and is obvious with normal mice feces difference; The fecal occult blood experiment is visible positive.10d rear section Mice Body quality is all than increasing to some extent before the modeling, and still lazy moving, the Mus hair is matt, and food-intake is lower than normally; Times of defecation increases, visible loose stool, mucus just, the stool blood experiment is positive, shows the modeling success.
Administering mode
Each is organized in experiment 11d and begins to gavage administration, blank group and model group gavage with normal saline 0.02ml/g, the SASP group gavages with the amount of the sulfasalazine suspension 0.02ml/g of quality 0.025g/mL, the crude drug concentration for the treatment of group preparation in this experiment gavages as the amount of 5g/ml granule oral liquid 0.02ml/g, be equivalent to 200 times of adult (60kg) day maximal dose 0.5g/kg, each is organized and gavages 1 every day, gavages altogether 10d.
Detect index
During each group treatment, the next day observe weight, the character of defecating and the situation of occulting blood, diet, activity etc. of mice, and in the standards of grading that 1d, 10d, 20d provide according to table 1 each group mice is carried out disease activity index (DAI) and marks.DAI=(the weight decline mark+stool character mark+mark of having blood in stool)/3.Put to death mice on the 21st day, separate colon, cut off enteric cavity along the mesentery edge, normal saline flushing is divided into 2 sections behind the tissue morphology of perusal colon.Leave and take the obvious position of pathological changes for one section and make the colon specimen, conventional film-making, HE dyeing, the descending histological examination of mirror; Measure the content of cytokine IL-10, TNF-α after another section homogenate.
Table 1 disease activity index standards of grading
Scoring | Weight rate of descent/% | The stool character | Have blood in stool |
0 | Nothing | Normally | Occult blood (-) |
1 | 1~≤5 | Half loose stool | Occult blood (+) |
2 | <5~≤10 | - | - |
3 | <10~≤15 | Loose stool | The naked eyes hemafecia |
4 | >15 | - | - |
Annotate: normal stool refers to the molding stool, and half loose stool refers to not adhere to pasty state, the half form stool of anus, and loose stool refers to adhere to rare watery stool of anus.
Statistical method
Measurement data adopts
χ is relatively adopted in expression between group
2Check, all data all adopt the SPSS12.0 statistical software to process.
The result
Each organizes the contrast of mice ordinary circumstance
From testing the 15th day, each modeling group ordinary circumstance all has improvement in various degree until treat end.Model control group mice mucus bloody purulent stool disappears, and to discharge shapeless loose stool as main, visible watery stool still increases before the activity individually, and appetite strengthens, but the bodily form becomes thin, and react slower, the fur tarnish; Indivedual stool in mice are occulted blood to test and are the weak positive, SASP group mice is discharged the shaping soft stool, feces water content compared with normal graininess stool is many, but visible indivedual mice stool is stiff, the autonomic activities showed increased, and appetite strengthens, Weight gain, the bodily form recovers, and the phenomenon that flocks together is rare, and the fur glossiness approaches normal; The fecal occult blood experiment is all negative, and the visible mice for the treatment of group is discharged shaped particles shape stool, and with normal phase ratio, no significant difference, autonomic activities showed increased, appetite strengthens, Weight gain, and the bodily form recovers, and the phenomenon that flocks together is rare, and the fur glossiness approaches normal; The fecal occult blood experiment is all negative.
Each organizes mice DAI appraisal result, the results are shown in Table 2.
Table 2 is respectively organized mice DAI appraisal result
Group | n | Before the modeling | Tested the 10th day | Tested the 20th day |
The blank group | 10 | 0.00±0.00 | 0.00±0.00 | 0.00±0.00 |
Model control group | 10 | 0.00±0.00 | 1.72±0.41 | 1.43±0.36 |
The SASP group | 10 | 0.00±0.00 | 1.52±0.33 | 0.51±0.19 |
The treatment by Chinese herbs group | 10 | 0.00±0.00 | 1.36±0.26 | 0.11±0.06 |
As can be seen from Table 2, adopt Chinese medicine composition of the present invention that chronic ulcerative colitis is had certain curative effect.
Each organizes mice pathological changes colon homogenate IL-10, the contrast of TNF-alpha content, the results are shown in Table 3.
Table 3 is respectively organized mice pathological changes colon homogenate IL-10, TNF-alpha content contrast (ngl
-1)
Group | n | IL-10 | TNF-α |
The blank group | 10 | 131.6±4.9 | 53.1±2.7 |
Model control group | 10 | 87.2±2.6 | 79.2±3.2 |
The SASP group | 10 | 112.8±3.1 | 64.0±3.5 |
The treatment by Chinese herbs group | 10 | 126.3±3.7 | 56.3±2.1 |
As can be seen from Table 3, compare with the blank group, the content of the IL-10 of model control group significantly reduces, the content of TNF-α significantly raises, and through after the Drug therapy, the content of the IL-10 of SASP group and treatment by Chinese herbs group raises, the content of TNF-α, and large than the SASP group that raise of the content for the treatment of by Chinese herbs group IL-10, the content for the treatment of by Chinese herbs group TNF-α large than the SASP group, proof, Chinese medicine composition of the present invention is improved IL-10 and reduces the effect of TNF-alpha content, thereby promotes the anti-inflammatory factors secretion, regulates immunoreation, reduce the release of inflammatory mediator, the control intestinal inflammation.
Embodiment 7 clinical experiment data
Physical data
173 routine patients are the patient in June, 2007 ~ 2010 year March, are divided into treatment group 92 example and matched group 81 examples according to the table of random number method.Male 57 examples in the treatment group, women 35 examples; 22 ~ 65 years old age, average 49.3 years old; The course of disease 6 months~10 years, average 7.1 years; Male 43 examples in the matched group, women 38 examples; 18 ~ 62 years old age, average 46.3 years old; The course of disease 8 months~9 years, average 6.3 years.
Diagnostic criteria and inclusive criteria
The doctor trained in Western medicine standard
Clinical manifestation: 1. persistence or repeated relapsing mucus hemafecia, stomachache, with General Symptoms in various degree, small number of patients only has constipation; 2. colonoscopy finding: the A. mucosa has congested, the edema of multiple front ulcer companion; B. the coarse graininess that is of mucosa, blood vessel is fuzzy, and is crisp easily hemorrhage, or with purulent secretion; C. visible false polyp, haustra of colon rust or disappearance; 3. mucosa biological tissue pathologic finding: be struvite variation, that simultaneously visible erosion, ulcer, lacunar abscess, body of gland are arranged is unusual, goblet cell reduces and the epithelium variation.According to clinical manifestation, it is diagnosable primary disease that colonoscopy has among A~C 1 and/or mucosa biological tissue pathological examination.
TCM syndrome diagnostic criteria
Have the performances such as in various degree stomachache, diarrhoea and mucus bloody purulent stool, abdominal distention, tenesmus, touching with the state of an illness, outbreak is common feature repeatedly.
Exclusion standard
Severe complication is arranged, such as local stenosis, block, bore a hole, colorectal cancer sexually transmitted disease (STD) change person; Serious endocrinopathy such as diabetes, abnormal thyroid function etc. are arranged; Hepatic and kidney function obstacle and hemopoietic system serious disease person.
Therapeutic Method
The granule of the oral embodiment of the invention 1 preparation for the treatment of group, each 10g, every day 2 times, each 1 time sooner or later, it is dissolved in the distilled water, oral administration, matched group according to the state of an illness divide gently, in, severe, slight oral sulfasalazine (Shanghai Xinyi Jiahua Pharmaceutical Co., Ltd.'s production), 0.25g a slice, 3 piece/timess, 3 times on the 1st; The concurrent infection person adds the secondary infection that maybe may cause with infection control with broad ectrum antibiotic.
More than 2 groups all to treat 1 month be 1 course for the treatment of, check intestinal mirrors carried out the short term effect evaluation after finished 2 courses for the treatment of.All cases is observed and was followed up a case by regular visits to 1 year, Estimating curative effect stability.
Curative effect determinate standard
Formulate with reference to " new Chinese medicine guideline of clinical investigations ".Clinical recovery: tcm clinical practice symptom, sign disappear or basic the disappearance.The intestinal mirror is rechecked and is seen that the recovery of mucosa pathological changes is normal, or the ulcer place has formed cicatrix.Produce effects: tcm clinical practice symptom, sign are obviously improved.The intestinal mirror is rechecked and is seen that mucosa pathological changes recovery extent reaches two more than the rank.Effectively: tcm clinical practice symptom, sign all take a favorable turn.The intestinal mirror is rechecked and is seen that mucosa pathological changes recovery extent reaches one more than the rank.Invalid: all without obviously improving, even increase the weight of, the improvement of enteroscopy mucosa pathological changes does not reach above standard, even increases the weight of for tcm clinical practice symptom, sign.
Statistical method
Measurement data adopts
χ is relatively adopted in expression between group
2Check, all data all adopt the SPSS12.0 statistical software to process.
The result
Two groups of Clinical efficacy comparisons the results are shown in Table 4.
Table 4 liang group Clinical efficacy comparison
Group | n | Clinical cure | Produce effects | Effectively | Invalid | Total effective rate % |
Treatment group | 92 | 46 | 31 | 11 | 4 | 95.65 |
Matched group | 81 | 22 | 29 | 17 | 13 | 83.95 |
2 groups of Clinical efficacy comparison differences have statistical significance (P<0.01), adopt the better effects if of traditional Chinese medicine composition for treating chronic ulcerative colitis of the present invention.
Late result is relatively treated after 1 year for two groups and is followed up a case by regular visits to curing patient and produce effects patient, the results are shown in Table 5.
Table 5 liang group late result relatively
Group | n | Recurrence | Relapse rate % |
Treatment group | 77 | 9 | 11.69% |
Matched group | 51 | 20 | 39.22% |
2 groups of late result comparing differences have statistical significance (P<0.01), adopt traditional Chinese medicine composition for treating of the present invention, and the Patients on Recurrence rate is significantly less than western medicine.
Embodiment 8 model cases
Zhao, man, 38 years old, workman.The first visit date: on July 21st, 2009, main suit: Recurrent Abdominal Pain, diarrhoea 2 years.Namely felt hypogastric region because suffering from diarrhoea after the crapulence ice medicated beer, rising per morning before 2 months and have a dull ache, pain is then wanted to rush down, tenesmus, and row's mucus loose stool increases the weight of during emotional lability, and every day 3~5 times, companion's gastral cavity is vexed, abdominal distention, fatigue and weakness, red tongue greasy fur, stringy and thready pulse.Effect is relatively poor after taking Chinese medicine and western medicine, and repeatedly the particularity pathogen is not found in stool examination on inspection, stool routine examination: leukocyte (+++), erythrocyte (++); Fibercolonscopy: descending colon, sigmoid colon, internal rectum mucosa be obvious congestion and edema all, is dispersed in ulcer, and the rotten to the corn face in a place touches hemorrhage.Report prompting: chronic ulcerative colitis, take the granule 1 of the embodiment of the invention 1 preparation, each 10g, every day 3 times, 1 month is 1 course for the treatment of, treats continuously 2 courses for the treatment of, symptom alleviates gradually after being used in conjunction 14 days, continuous with transference cure after 6 weeks, colonoscope is checked intestinal wall without redness, shallow table ulcer healing.Advise that it is avoided eating anything raw or cold, the product of the stimulation such as pungent, keep happy, follow up a case by regular visits to and had no recurrence in 1 year.
This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away to any simple modification, equivalent variations and remodeling that above embodiment does, still belongs to the protection domain of technical solution of the present invention according to technical spirit of the present invention.
Claims (10)
1. Chinese medicine composition that is used for the treatment of chronic ulcerative colitis, it is characterized in that: the crude drug of described Chinese medicine composition comprises Radix Rehmanniae Preparata, Caulis Polygoni Multiflori, Myrrha, Rhizoma Dioscoreae, Rhizoma Polygonati, Fructus Chebulae, Herba Asari, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Gentianae, Folium Isatidis, Rhizoma Wenyujin Concisum, Radix Vladimiriae, Fructus Viticis, Radix Salviae Miltiorrhizae, Polyporus, Pseudobulbus Bletillae (Rhizoma Bletillae), Galla Chinensis, the Rhizoma Pinelliae, Fructus Alpiniae Oxyphyllae, catechu, Rhizoma Saururi (Herba Saururi), Herba Senecionis Scandentis, Fructus Aristolochiae, Herba Polygoni cymosi.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that: the weight portion of described each crude drug of Chinese medicine composition is respectively Radix Rehmanniae Preparata 33 weight portions ~ 43 weight portions, Caulis Polygoni Multiflori 27 weight portions ~ 37 weight portions, Myrrha 16 weight portions ~ 26 weight portions, Rhizoma Dioscoreae 41 weight portions ~ 51 weight portions, Rhizoma Polygonati 36 weight portions ~ 46 weight portions, Fructus Chebulae's 20 weight portions ~ 30 weight portions, Herba Asari 13 weight portions ~ 23 weight portions, Radix Et Rhizoma Rhei 22 weight portions ~ 32 weight portions, the Radix Pulsatillae 51 weight portions ~ 61 weight portions, Radix Gentianae 35 weight portions ~ 45 weight portions, Folium Isatidis 72 weight portions ~ 82 weight portions, Rhizoma Wenyujin Concisum 28 weight portions ~ 38 weight portions, Radix Vladimiriae 12 weight portions ~ 22 weight portions, Fructus Viticis 19 weight portions ~ 29 weight portions, Radix Salviae Miltiorrhizae 31 weight portions ~ 41 weight portions, Polyporus 29 weight portions ~ 39 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 30 weight portions ~ 40 weight portions, Galla Chinensis 25 weight portions ~ 35 weight portions, the Rhizoma Pinelliae 21 weight portions ~ 31 weight portions, Fructus Alpiniae Oxyphyllae 34 weight portions ~ 44 weight portions, catechu 16 weight portions ~ 26 weight portions, Rhizoma Saururi (Herba Saururi) 41 weight portions ~ 51 weight portions, Herba Senecionis Scandentis 22 weight portions ~ 32 weight portions, Fructus Aristolochiae 19 weight portions ~ 29 weight portions, Herba Polygoni cymosi 27 weight portions ~ 37 weight portions.
3. Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that: the weight portion of described each crude drug of Chinese medicine composition is respectively Radix Rehmanniae Preparata 35 weight portions ~ 41 weight portions, Caulis Polygoni Multiflori 29 weight portions ~ 35 weight portions, Myrrha 18 weight portions ~ 24 weight portions, Rhizoma Dioscoreae 43 weight portions ~ 49 weight portions, Rhizoma Polygonati 38 weight portions ~ 44 weight portions, Fructus Chebulae's 22 weight portions ~ 28 weight portions, Herba Asari 15 weight portions ~ 21 weight portions, Radix Et Rhizoma Rhei 24 weight portions ~ 30 weight portions, the Radix Pulsatillae 53 weight portions ~ 59 weight portions, Radix Gentianae 37 weight portions ~ 43 weight portions, Folium Isatidis 74 weight portions ~ 80 weight portions, Rhizoma Wenyujin Concisum 30 weight portions ~ 36 weight portions, Radix Vladimiriae 14 weight portions ~ 20 weight portions, Fructus Viticis 21 weight portions ~ 27 weight portions, Radix Salviae Miltiorrhizae 33 weight portions ~ 39 weight portions, Polyporus 31 weight portions ~ 37 weight portions, Pseudobulbus Bletillae (Rhizoma Bletillae) 32 weight portions ~ 38 weight portions, Galla Chinensis 27 weight portions ~ 33 weight portions, the Rhizoma Pinelliae 23 weight portions ~ 29 weight portions, Fructus Alpiniae Oxyphyllae 36 weight portions ~ 42 weight portions, catechu 18 weight portions ~ 24 weight portions, Rhizoma Saururi (Herba Saururi) 43 weight portions ~ 49 weight portions, Herba Senecionis Scandentis 24 weight portions ~ 30 weight portions, Fructus Aristolochiae 21 weight portions ~ 27 weight portions, Herba Polygoni cymosi 29 weight portions ~ 35 weight portions.
4. such as the described Chinese medicine composition of claims 1 to 3, it is characterized in that: the dosage form of described Chinese medicine composition is powder, granule, oral liquid, pill, capsule, tablet.
5. the preparation method of the described Chinese medicine composition of claim 1 to 4, it is characterized in that: preparation method is specially,
The first step, with the Radix Pulsatillae, Radix Gentianae, Folium Isatidis, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Saururi (Herba Saururi), Herba Senecionis Scandentis and Herba Polygoni cymosi are pulverized, be mixed in proportion, obtain mixture, the adding determining alcohol is 70% ~ 80% the even moistening of ethanol, the mass ratio of mixture and ethanol is 1:1 ~ 1:2, and airtight placement 12h ~ 18h drops in the percolate pot, continue to add determining alcohol with respect to 2 ~ 4 times of mixture qualities and be 70% ~ 80% ethanol, continue dipping 6h ~ 12h, percolation, flow are per minute 5 ~ 7ml, collect percolate, to filter, filtrate is-0.06 at pressure~-0.04MPa, temperature is that concentrating under reduced pressure becomes the extractum of 65 ℃ of relative densities 1.15 ~ 1.20 under 65 ℃ of conditions;
Second step, with macroporous resin adsorption on the extractum, the quality of extractum and the mass ratio of macroporous adsorbent resin are 1:1 ~ 2, use first the water elution with respect to 0.3 ~ 0.5 times of the quality of macroporous adsorbent resin, using determining alcohol with respect to 4 ~ 6 times of the quality of macroporous adsorbent resin is 60% ~ 80% ethanol elution again, collects eluent, the concentrating under reduced pressure desolventizing, obtain and get dry extract, be ground into fine powder;
The 3rd step, remaining component is pulverized, be mixed in proportion, obtain mixture, decoct with water 3 times, the 1st amount of water is 8 times of mixture quality, decocts 2h, the 2nd time and the 3rd amount of water are 6 times of mixture quality, decoction liquor after each the decoction is all filtered, and merges filtrate, adds determining alcohol and is 70%~80% ethanol to alcohol volume content and reach 50%~60%, hold over night, again filter, filtrate be-0.08 at pressure~-0.06MPa, temperature are under 75 ℃ of conditions, concentrate desolventizing, obtain and get dry extract, be ground into fine powder;
In the 4th step, the fine powder and the 3rd that second step is obtained goes on foot the fine powder mixing that obtains, and spray drying according to needed dosage form, according to the conventional preparation method of each dosage form, is prepared into powder, granule, oral liquid, pill, capsule, tablet.
6. the preparation method of the described Chinese medicine composition of claim 1 to 4, it is characterized in that: when the dosage form of described Chinese medicine composition was granule, preparation method was specially,
The first step, with the Radix Pulsatillae, Radix Gentianae, Folium Isatidis, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Saururi (Herba Saururi), Herba Senecionis Scandentis and Herba Polygoni cymosi are pulverized, be mixed in proportion, obtain mixture, the adding determining alcohol is 70% ~ 80% the even moistening of ethanol, the mass ratio of mixture and ethanol is 1:1 ~ 1:2, and airtight placement 12h ~ 18h drops in the percolate pot, continue to add determining alcohol with respect to 2 ~ 4 times of mixture qualities and be 70% ~ 80% ethanol, continue dipping 6h ~ 12h, percolation, flow are per minute 5 ~ 7ml, collect percolate, to filter, filtrate is-0.06 at pressure~-0.04MPa, temperature is that concentrating under reduced pressure becomes the extractum of 65 ℃ of relative densities 1.15 ~ 1.20 under 65 ℃ of conditions;
Second step, with macroporous resin adsorption on the extractum, the quality of extractum and the mass ratio of macroporous adsorbent resin are 1:1 ~ 2, use first the water elution with respect to 0.3 ~ 0.5 times of the quality of macroporous adsorbent resin, using determining alcohol with respect to 4 ~ 6 times of the quality of macroporous adsorbent resin is 60% ~ 80% ethanol elution again, collects eluent, the concentrating under reduced pressure desolventizing, obtain and get dry extract, be ground into fine powder;
The 3rd step, remaining component is pulverized, be mixed in proportion, obtain mixture, decoct with water 3 times, the 1st amount of water is 8 times of mixture quality, decocts 2h, the 2nd time and the 3rd amount of water are 6 times of mixture quality, decoction liquor after each the decoction is all filtered, and merges filtrate, adds determining alcohol and is 70%~80% ethanol to alcohol volume content and reach 50%~60%, hold over night, again filter, filtrate be-0.08 at pressure~-0.06MPa, temperature are under 75 ℃ of conditions, concentrate desolventizing, obtain and get dry extract, be ground into fine powder;
In the 4th step, the fine powder and the 3rd that second step is obtained goes on foot the fine powder mixing that obtains, spray drying, and adding determining alcohol is 75% ~ 85% ethanol soft material processed, granulate with oscillating granulator, oven dry under 60 ℃, granulate gets medicinal granule of the present invention.
7. the preparation method of the described Chinese medicine composition of claim 1 to 4, it is characterized in that: when the dosage form of described Chinese medicine composition was powder, preparation method was specially,
The first step, with the Radix Pulsatillae, Radix Gentianae, Folium Isatidis, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Saururi (Herba Saururi), Herba Senecionis Scandentis and Herba Polygoni cymosi are pulverized, be mixed in proportion, obtain mixture, the adding determining alcohol is 70% ~ 80% the even moistening of ethanol, the mass ratio of mixture and ethanol is 1: 1 ~ 1:2, and airtight placement 12h ~ 18h drops in the percolate pot, continue to add determining alcohol with respect to 2 ~ 4 times of mixture qualities and be 70% ~ 80% ethanol, continue dipping 6h ~ 12h, percolation, flow are per minute 5 ~ 7ml, collect percolate, to filter, filtrate is-0.06 at pressure~-0.04MPa, temperature is that concentrating under reduced pressure becomes the extractum of 65 ℃ of relative densities 1.15 ~ 1.20 under 65 ℃ of conditions;
Second step, with macroporous resin adsorption on the extractum, the quality of extractum and the mass ratio of macroporous adsorbent resin are 1:1 ~ 2, use first the water elution with respect to 0.3 ~ 0.5 times of the quality of macroporous adsorbent resin, using determining alcohol with respect to 4 ~ 6 times of the quality of macroporous adsorbent resin is 60% ~ 80% ethanol elution again, collects eluent, the concentrating under reduced pressure desolventizing, obtain and get dry extract, be ground into fine powder;
The 3rd step, remaining component is pulverized, be mixed in proportion, obtain mixture, decoct with water 3 times, the 1st amount of water is 8 times of mixture quality, decocts 2h, the 2nd time and the 3rd amount of water are 6 times of mixture quality, decoction liquor after each the decoction is all filtered, and merges filtrate, adds determining alcohol and is 70%~80% ethanol to alcohol volume content and reach 50%~60%, hold over night, again filter, filtrate be-0.08 at pressure~-0.06MPa, temperature are under 75 ℃ of conditions, concentrate desolventizing, obtain and get dry extract, be ground into fine powder;
In the 4th step, the fine powder and the 3rd that second step is obtained goes on foot the fine powder mixing that obtains, and spray drying obtains powder.
8. Chinese medicinal composition granules that is used for the treatment of chronic ulcerative colitis, it is characterized in that: the crude drug of described granule comprises Radix Rehmanniae Preparata, Caulis Polygoni Multiflori, Myrrha, Rhizoma Dioscoreae, Rhizoma Polygonati, Fructus Chebulae, Herba Asari, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Gentianae, Folium Isatidis, Rhizoma Wenyujin Concisum, Radix Vladimiriae, Fructus Viticis, Radix Salviae Miltiorrhizae, Polyporus, Pseudobulbus Bletillae (Rhizoma Bletillae), Galla Chinensis, the Rhizoma Pinelliae, Fructus Alpiniae Oxyphyllae, catechu, Rhizoma Saururi (Herba Saururi), Herba Senecionis Scandentis, Fructus Aristolochiae, Herba Polygoni cymosi.
9. Chinese medicine composition composition powders that is used for the treatment of chronic ulcerative colitis, it is characterized in that: the crude drug of described powder comprises Radix Rehmanniae Preparata, Caulis Polygoni Multiflori, Myrrha, Rhizoma Dioscoreae, Rhizoma Polygonati, Fructus Chebulae, Herba Asari, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Gentianae, Folium Isatidis, Rhizoma Wenyujin Concisum, Radix Vladimiriae, Fructus Viticis, Radix Salviae Miltiorrhizae, Polyporus, Pseudobulbus Bletillae (Rhizoma Bletillae), Galla Chinensis, the Rhizoma Pinelliae, Fructus Alpiniae Oxyphyllae, catechu, Rhizoma Saururi (Herba Saururi), Herba Senecionis Scandentis, Fructus Aristolochiae, Herba Polygoni cymosi.
The described Chinese medicine composition of claim 1 to 4 for the preparation of the treatment chronic ulcerative colitis medicine in application.
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103211993A (en) * | 2013-04-25 | 2013-07-24 | 青岛农业大学 | Traditional Chinese medicine composition for treating porcine transmissible gastroenteritis |
CN105412609A (en) * | 2015-12-30 | 2016-03-23 | 张晓莉 | Traditional Chinese medicine for treating hepatic stagnation and spleen deficiency type ulcerative colitis and preparation method |
CN105726903A (en) * | 2016-03-05 | 2016-07-06 | 陈红 | Pharmaceutical preparation for treating colitis and application thereof |
CN105770101A (en) * | 2016-04-06 | 2016-07-20 | 梁海月 | Medicine for treating ulcerative colitis |
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CN101259245A (en) * | 2008-04-21 | 2008-09-10 | 北京中科仁和科技有限公司 | Chinese medicinal composition for treating ulcerative colitis and preparation thereof |
CN101954035A (en) * | 2010-09-12 | 2011-01-26 | 刘秀娥 | Chinese medicinal decoction for treating chronic colitis |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101259245A (en) * | 2008-04-21 | 2008-09-10 | 北京中科仁和科技有限公司 | Chinese medicinal composition for treating ulcerative colitis and preparation thereof |
CN101954035A (en) * | 2010-09-12 | 2011-01-26 | 刘秀娥 | Chinese medicinal decoction for treating chronic colitis |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103211993A (en) * | 2013-04-25 | 2013-07-24 | 青岛农业大学 | Traditional Chinese medicine composition for treating porcine transmissible gastroenteritis |
CN105412609A (en) * | 2015-12-30 | 2016-03-23 | 张晓莉 | Traditional Chinese medicine for treating hepatic stagnation and spleen deficiency type ulcerative colitis and preparation method |
CN105726903A (en) * | 2016-03-05 | 2016-07-06 | 陈红 | Pharmaceutical preparation for treating colitis and application thereof |
CN105770101A (en) * | 2016-04-06 | 2016-07-20 | 梁海月 | Medicine for treating ulcerative colitis |
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