CN103041090B - Chinese medicament oral liquid for treating pelvic inflammation and preparation method thereof - Google Patents
Chinese medicament oral liquid for treating pelvic inflammation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicament oral liquid for treating pelvic inflammation and a preparation method thereof, and belongs to the field of Chinese medicaments. The Chinese medicament is prepared from the following raw materials: 9-25 parts of processed rhizoma cyperi, 9-25 parts of szechwan Chinaberry fruit, 9-25 parts of rhizoma corydalis, 9-25 parts of trogopterus dung, 9-25 parts of Chinese angelica, 9-25 parts of combined spicebush roots, 6-15 parts of bitter orange, 6-15 parts of costustoot and 3-9 parts of myrrh. The Chinese medicament oral liquid has the functions of promoting blood circulation to remove blood stasis and clearing heat and promoting dieresis, and is a Chinese medicament composition which is safe and reliable, high in using rate of effective components and quick in effect taking and has no any toxic and side effects.
Description
Technical field
The present invention relates to a kind of Chinese medicine oral liquid for the treatment of pelvic inflammatory disease, belong to the field of Chinese medicines.
Background technology
Pelvic inflammatory disease refers to the inflammatory damage of reproductive tract in women and proximity structure thereof, and pelvic inflammatory disease is a kind of commonly encountered diseases, the frequently-occurring disease of gynecological clinic, and relapse rate is high.Be more common in Women of Childbearing Age, wherein common in young sexual maturity women of 20-35 year.World Health Organization (WHO) estimates, sexually transmitted disease (STD) is spread unchecked and is caused every year newly-increased more than 300,000,000 3 thousand ten thousand std patients in the whole world, wherein have 10% ~ 20% will develop into chronic pelvic inflammatory disease, patient's the physical and mental health of consequently having brought the serious impression of a series of families and social problem such as long-term chronic pelvic inflammatory disease, sterility and infertility or ectopic pregnancy.
The western medical treatment Main Means of at present this disease being taked is application antibiotic, but apply merely the case most unsatisfactory curative effect of antibiotic western medical treatment to the extensive adhesion of laparoscopy confirmation formation pelvic inflammatory disease, severe bilateral adnexa pathological changes, obvious inflammatory mass, abscess etc., transfer chronic or repeatability pelvic inflammatory disease more to, finally cause the severe complication such as infertility and intractable pelvic pain.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine oral liquid for the treatment of pelvic inflammatory disease, it has effect of blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis.
The present invention is achieved through the following technical solutions:
Treat a Chinese medicine oral liquid for pelvic inflammatory disease, made by the each raw material of following weight portion: 9 ~ 25 parts of Rhizoma Cyperi (processed), 9 ~ 25 parts of Fructus Toosendans, 9 ~ 25 parts of Rhizoma Corydalis, 9 ~ 25 parts of Oletum Trogopteroris, 9 ~ 25 parts of Radix Angelicae Sinensis, 9 ~ 25 parts of the Radixs Linderae, 6 ~ 15 parts of Fructus Aurantiis, 6 ~ 15 parts of the Radix Aucklandiae, 3 ~ 9 parts of Myrrhas.
Preferably, each parts by weight of raw materials is: 18 parts of Rhizoma Cyperi (processed), 18 parts of Fructus Toosendans, 18 parts of Rhizoma Corydalis, 18 parts of Oletum Trogopteroris, 18 parts of Radix Angelicae Sinensis, 18 parts of the Radixs Linderae, 9 parts of Fructus Aurantiis, 9 parts of the Radix Aucklandiae, 6 parts of Myrrhas.
Pharmacological action:
Rhizoma Cyperi (processed): acrid in the mouth, micro-hardship, sweet, property is flat.There is depressed liver-energy dispersing and QI regulating, effect of menstruction regulating and pain relieving.
Fructus Toosendan: bitter in the mouth, cold in nature; Slightly poisonous.Return liver, small intestinal, urinary bladder channel.Have catharsis liver-heat, promoting the circulation of QI to relieve pain, have the effect except damp and hot, clearing away liver-fire, pain relieving, parasite killing.
Rhizoma Corydalis: bitter in the mouth, pungent, warm in nature; Return liver, the heart, stomach warp.There is promoting blood circulation to remove blood stasis, effect of promoting the circulation of QI to relieve pain.
Oletum Trogopterori: sweet in the mouth, warm in nature.There is effect of promoting blood circulation to remove blood stasis.
Radix Angelicae Sinensis: sweet in the mouth, pungent, bitter, warm in nature.Return liver, the heart, spleen channel.Enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, the effect of moisturizing laxation.
The Radix Linderae: pungent, temperature.Return lung, spleen, kidney, urinary bladder channel.There are promoting the circulation of QI to relieve pain, effect of warming kidney for dispelling cold.
Fructus Aurantii: bitter in the mouth, acid, cold nature.There is dispelling the stagnated QI, row expectorant, effect of removing food stagnancy.
The Radix Aucklandiae: acrid in the mouth, hardship, warm in nature.Return spleen, stomach, liver, lung meridian.In reasonable controlled atmosphere, effect of drying dampness to eliminate phlegm.
Myrrha: bitter in the mouth, pungent, property is flat.Enter liver, spleen, the heart, kidney channel.There is loose blood blood stasis removing, effect of subduing swelling and relieving pain.
The present invention's various raw materials used can be bought and obtain from market, and its specification is that pharmaceutical grade or food stage all can.
Another technical problem to be solved by this invention is to provide a kind of preparation method of preparing above-mentioned Chinese medicine oral liquid.
Another technical problem to be solved by this invention is achieved through the following technical solutions:
A preparation method for the treatment of the Chinese medicine oral liquid of pelvic inflammatory disease, comprising:
(1), by Rhizoma Cyperi (processed), Fructus Toosendan, Rhizoma Corydalis, Oletum Trogopterori, Radix Angelicae Sinensis, the Radix Linderae, Fructus Aurantii, the Radix Aucklandiae, Myrrha, above nine tastes take raw material for standby in proportion.
(2) Rhizoma Cyperi (processed), Rhizoma Corydalis, Radix Angelicae Sinensis, the Radix Linderae, the Radix Aucklandiae, Myrrha section, decoct with water 2 hours for the first time 3 times, second and third time each 1 hour, collecting decoction, filtered, filtrate is concentrated and add 2mol/L hydrochloric acid solution to regulate in right amount pH value to 7.0 in the time of 80 ℃, then adds equivalent ethanol, is stirred to dissolve, filter, filtrate regulates pH value to 2.0 with 2mol/L hydrochloric acid solution, and 60 ℃ are incubated 30 minutes, leave standstill 12 hours, filter, precipitation is washed till pH value 7.0 with ethanol, waves most ethanol for subsequent use;
(3) Fructus Toosendan, Oletum Trogopterori, Fructus Aurantii added water after warm macerating half an hour, decoct secondary, each 1.5 hours, collecting decoction, filter, it is 1.20～1.25(70～80 ℃ surveys that filtrate is concentrated into relative density), while being chilled to 40 ℃, slowly add ethanol, make to reach 75% containing alcohol amount, fully stir, leave standstill 12 hours, leaching supernatant, residue adds 75% appropriate amount of ethanol, stir evenly, leave standstill 12 hours, filter, merge ethanol, reclaim ethanol extremely without alcohol taste, add Rhizoma Cyperi (processed), Rhizoma Corydalis, Radix Angelicae Sinensis, the Radix Linderae, the Radix Aucklandiae, Myrrha extract, and it is appropriate to add water, regulate pH value to 7.0 with 40% sodium hydroxide solution, stir evenly, cold preservation (4～8 ℃) 72 hours, filter, filtrate adds sucrose 300g, be stirred to dissolve, add again essence appropriate and regulate pH value to 7.0, add water and make 1000ml, stir evenly, leave standstill 12 hours, filter, fill, sterilizing, obtain.
It is raw material that the present invention adopts pure Chinese medicine, according to the pathogenic factor of pelvic inflammatory disease and Clinical symptoms, carries out prescription and be prepared from the basis that is not raw-material activity under instruction of Chinese Medicine theory.Show through clinical efficacy, this medicine has definite curative effect to pelvic inflammatory disease, is a kind of ideal treatment medication of Patients with Pelvic Inflammatory Disease.
Model case
Case 1: Mrs Yang, 30 years old, medical history: the few abdomen pain falling inflation of patient and lumbosacral region swelling and pain more than 1 year, increase the weight of menstrual period, closely half a year, leucorrhea amount was many, yellow skin.Gynaecological examination: pudendum (gynaecological examination: pudendum (), vagina is smooth, inside sees medium yellow leucorrhea, odorless) cervix uteri: I erosion, position after the body of palace, mobility is poor, tenderness, double accessory thickens tenderness, and leucorrhea is common: cleannes III, have no drip mould, examine as chronic pelvic inflammatory disease, by Drug therapy of the present invention a week, after treatment, patient conscious stomachache and the swollen pain of lumbosacral region acid obviously reduced, gynaecological examination check: uterus tenderness disappears, and double accessory tenderness alleviates.
Case 2: Mrs Liu, 25 years old patient main suit, suffers from chronic pelvic inflammatory disease 1 year, recently feels abdominal part falling inflation, and pain, while are with the symptom such as the soreness of waist, pain in the lumbar region.After taking two courses for the treatment of of medicine of the present invention, patient's above-mentioned symptom disappears.Follow up a case by regular visits to 1 year without recurrence.
Case 3: Mrs Wang, 35 years old, medical history: patient's hypogastralgia 3 years, profuse leukorrhea, color is white, matter is rare, time the taste of begging, soreness of waist pain, two is just normal.Check: hypogastric region tenderness, without rebound tenderness, full abdomen dance patho-tumor.Light red tongue is fat, and limit has tooth to print, and thick fur is white, a little less than moderate pulse.Diagnosis: pelvic inflammatory disease, the traditional Chinese medical science: leukorrheal diseases.Take the present invention and treat transference cure after 3 weeks.
The specific embodiment
Embodiment 1 the present invention treats the preparation of pelvic inflammatory disease Chinese medicine oral liquid
Take each raw material (unit: g): Rhizoma Cyperi (processed) 18, Fructus Toosendan 18, Rhizoma Corydalis 18, Oletum Trogopterori 18, Radix Angelicae Sinensis 18, the Radix Linderae 18, Fructus Aurantii 9, the Radix Aucklandiae 9, Myrrha 6 by following weight.
Preparation method:
(1), by Rhizoma Cyperi (processed), Fructus Toosendan, Rhizoma Corydalis, Oletum Trogopterori, Radix Angelicae Sinensis, the Radix Linderae, Fructus Aurantii, the Radix Aucklandiae, Myrrha, above nine tastes take raw material for standby in proportion.
(2) Rhizoma Cyperi (processed), Rhizoma Corydalis, Radix Angelicae Sinensis, the Radix Linderae, the Radix Aucklandiae, Myrrha section, decoct with water 2 hours for the first time 3 times, second and third time each 1 hour, collecting decoction, filtered, filtrate is concentrated and add 2mol/L hydrochloric acid solution to regulate in right amount pH value to 7.0 in the time of 80 ℃, then adds equivalent ethanol, is stirred to dissolve, filter, filtrate regulates pH value to 2.0 with 2mol/L hydrochloric acid solution, and 60 ℃ are incubated 30 minutes, leave standstill 12 hours, filter, precipitation is washed till pH value 7.0 with ethanol, waves most ethanol for subsequent use;
(3) Fructus Toosendan, Oletum Trogopterori, Fructus Aurantii added water after warm macerating half an hour, decoct secondary, each 1.5 hours, collecting decoction, filter, it is 1.20～1.25(70～80 ℃ surveys that filtrate is concentrated into relative density), while being chilled to 40 ℃, slowly add ethanol, make to reach 75% containing alcohol amount, fully stir, leave standstill 12 hours, leaching supernatant, residue adds 75% appropriate amount of ethanol, stir evenly, leave standstill 12 hours, filter, merge ethanol, reclaim ethanol extremely without alcohol taste, add Rhizoma Cyperi (processed), Rhizoma Corydalis, Radix Angelicae Sinensis, the Radix Linderae, the Radix Aucklandiae, Myrrha extract, and it is appropriate to add water, regulate pH value to 7.0 with 40% sodium hydroxide solution, stir evenly, cold preservation (4～8 ℃) 72 hours, filter, filtrate adds sucrose 300g, be stirred to dissolve, add again essence appropriate and regulate pH value to 7.0, add water and make 1000ml, stir evenly, leave standstill 12 hours, filter, fill, sterilizing, obtain.
Usage: oral, 3 times on the one, each 40 milliliters
Embodiment 2 the present invention treat the preparation of pelvic inflammatory disease Chinese medicine oral liquid
Take each raw material (unit: g): Rhizoma Cyperi (processed) 20, Fructus Toosendan 20, Rhizoma Corydalis 18, Oletum Trogopterori 18, Radix Angelicae Sinensis 20, the Radix Linderae 18, Fructus Aurantii 12, the Radix Aucklandiae 12, Myrrha 6 by following weight.
Preparation method:
(1), by Rhizoma Cyperi (processed), Fructus Toosendan, Rhizoma Corydalis, Oletum Trogopterori, Radix Angelicae Sinensis, the Radix Linderae, Fructus Aurantii, the Radix Aucklandiae, Myrrha, above nine tastes take raw material for standby in proportion.
(2) Rhizoma Cyperi (processed), Rhizoma Corydalis, Radix Angelicae Sinensis, the Radix Linderae, the Radix Aucklandiae, Myrrha section, decoct with water 2 hours for the first time 3 times, second and third time each 1 hour, collecting decoction, filtered, filtrate is concentrated and add 2mol/L hydrochloric acid solution to regulate in right amount pH value to 7.0 in the time of 80 ℃, then adds equivalent ethanol, is stirred to dissolve, filter, filtrate regulates pH value to 2.0 with 2mol/L hydrochloric acid solution, and 60 ℃ are incubated 30 minutes, leave standstill 12 hours, filter, precipitation is washed till pH value 7.0 with ethanol, waves most ethanol for subsequent use;
(3) Fructus Toosendan, Oletum Trogopterori, Fructus Aurantii added water after warm macerating half an hour, decoct secondary, each 1.5 hours, collecting decoction, filter, it is 1.20～1.25(70～80 ℃ surveys that filtrate is concentrated into relative density), while being chilled to 40 ℃, slowly add ethanol, make to reach 75% containing alcohol amount, fully stir, leave standstill 12 hours, leaching supernatant, residue adds 75% appropriate amount of ethanol, stir evenly, leave standstill 12 hours, filter, merge ethanol, reclaim ethanol extremely without alcohol taste, add Rhizoma Cyperi (processed), Rhizoma Corydalis, Radix Angelicae Sinensis, the Radix Linderae, the Radix Aucklandiae, Myrrha extract, and it is appropriate to add water, regulate pH value to 7.0 with 40% sodium hydroxide solution, stir evenly, cold preservation (4～8 ℃) 72 hours, filter, filtrate adds sucrose 300g, be stirred to dissolve, add again essence appropriate and regulate pH value to 7.0, add water and make 1000ml, stir evenly, leave standstill 12 hours, filter, fill, sterilizing, obtain.
Usage: oral, 3 times on the one, each 40 milliliters.
Claims (2)
1. treat the preparation method of the Chinese medicine oral liquid of pelvic inflammatory disease for one kind, it is characterized in that being prepared from by following methods: (1), by 9 ~ 25 parts of Rhizoma Cyperi (processed), 9 ~ 25 parts of Fructus Toosendans, 9 ~ 25 parts of Rhizoma Corydalis, 9 ~ 25 parts of Oletum Trogopteroris, 9 ~ 25 parts of Radix Angelicae Sinensis, 9 ~ 25 parts of the Radixs Linderae, 6 ~ 15 parts of Fructus Aurantiis, 6 ~ 15 parts of the Radix Aucklandiae, 3 ~ 9 parts of Myrrhas, above nine tastes take raw material for standby in proportion;
(2) by Rhizoma Cyperi (processed), Rhizoma Corydalis, Radix Angelicae Sinensis, the Radix Linderae, the Radix Aucklandiae, Myrrha section, decoct with water 3 times, 2 hours for the first time, second and third time each 1 hour, collecting decoction, filter, filtrate is concentrated and add 2mol/L hydrochloric acid solution to regulate in right amount pH value to 7.0 in the time of 80 ℃, then adds equivalent ethanol, be stirred to dissolve, filter, filtrate regulates pH value to 2.0 with 2mol/L hydrochloric acid solution, and 60 ℃ are incubated 30 minutes, leave standstill 12 hours, filter, precipitation is washed till pH value 7.0 with ethanol, waves most ethanol for subsequent use;
(3) Fructus Toosendan, Oletum Trogopterori, Fructus Aurantii added water after warm macerating half an hour, decoct secondary, each 1.5 hours, collecting decoction, filter, filtrate is concentrated into and in the time of 70～80 ℃, surveys relative density is 1.20～1.25, while being chilled to 40 ℃, slowly add ethanol, make to reach 75% containing alcohol amount, fully stir, leave standstill 12 hours, leaching supernatant, residue adds 75% appropriate amount of ethanol, stir evenly, leave standstill 12 hours, filter, merge ethanol, reclaim ethanol extremely without alcohol taste, add Rhizoma Cyperi (processed), Rhizoma Corydalis, Radix Angelicae Sinensis, the Radix Linderae, the Radix Aucklandiae, Myrrha extract, and it is appropriate to add water, regulate pH value to 7.0 with 40% sodium hydroxide solution, stir evenly, cold preservation 72 hours at 4～8 ℃, filter, filter
Liquid adds sucrose 300g, is stirred to dissolve, then adds essence appropriate and regulate pH value to 7.0, adds water and makes 1000ml, stirs evenly, and leaves standstill 12 hours, filtration, and fill, sterilizing, to obtain final product.
2. the preparation method of a kind of Chinese medicine oral liquid for the treatment of pelvic inflammatory disease according to claim 1, is characterized in that, is prepared from by following methods:
(1) 18 parts of Rhizoma Cyperi (processed), 18 parts of Fructus Toosendans, 18 parts of Rhizoma Corydalis, 18 parts of Oletum Trogopteroris, 18 parts of Radix Angelicae Sinensis, 18 parts of the Radixs Linderae, 9 parts of Fructus Aurantiis, 9 parts of the Radix Aucklandiae, 6 parts of Myrrhas, above nine tastes take raw material for standby in proportion;
(2) Rhizoma Cyperi (processed), Rhizoma Corydalis, Radix Angelicae Sinensis, the Radix Linderae, the Radix Aucklandiae, Myrrha section, decoct with water 2 hours for the first time 3 times, second and third time each 1 hour, collecting decoction, filtered, filtrate is concentrated and add 2mol/L hydrochloric acid solution to regulate in right amount pH value to 7.0 in the time of 80 ℃, then adds equivalent ethanol, is stirred to dissolve, filter, filtrate regulates pH value to 2.0 with 2mol/L hydrochloric acid solution, and 60 ℃ are incubated 30 minutes, leave standstill 12 hours, filter, precipitation is washed till pH value 7.0 with ethanol, waves most ethanol for subsequent use;
(3) Fructus Toosendan, Oletum Trogopterori, Fructus Aurantii added water after warm macerating half an hour, decoct secondary, each 1.5 hours, collecting decoction, filter, filtrate is concentrated into and in the time of 70～80 ℃, surveys relative density is 1.20～1.25, while being chilled to 40 ℃, slowly add ethanol, make to reach 75% containing alcohol amount, fully stir, leave standstill 12 hours, leaching supernatant, residue adds 75% appropriate amount of ethanol, stir evenly, leave standstill 12 hours, filter, merge ethanol, reclaim ethanol extremely without alcohol taste, add Rhizoma Cyperi (processed), Rhizoma Corydalis, Radix Angelicae Sinensis, the Radix Linderae, the Radix Aucklandiae, Myrrha extract, and it is appropriate to add water, regulate pH value to 7.0 with 40% sodium hydroxide solution, stir evenly, cold preservation 72 hours at 4～8 ℃, filter, filtrate adds sucrose 300g, be stirred to dissolve, add again essence appropriate and regulate pH value to 7.0, add water and make 1000ml, stir evenly, leave standstill 12 hours, filter, fill, sterilizing, obtain.
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| CN201310012022.5A CN103041090B (en) | 2013-01-14 | 2013-01-14 | Chinese medicament oral liquid for treating pelvic inflammation and preparation method thereof |
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| CN103405643B (en) * | 2013-07-26 | 2015-04-22 | 屈力军 | Chinese herbal medicine preparation for curing endometrial disease, infertility and habitual abortion |
| CN105250964A (en) * | 2015-11-10 | 2016-01-20 | 张霞 | Traditional Chinese medicine capable of promoting blood circulation to remove blood stasis and preparation method thereof |
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| CN101732662B (en) * | 2009-12-29 | 2011-09-21 | 广东德鑫制药有限公司 | Chinese medicinal composition for treating pelvic inflammatory disease and preparation method thereof |
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