CN103028136A - Hydrocolloid dressing and preparation method thereof - Google Patents

Hydrocolloid dressing and preparation method thereof Download PDF

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Publication number
CN103028136A
CN103028136A CN2012105460074A CN201210546007A CN103028136A CN 103028136 A CN103028136 A CN 103028136A CN 2012105460074 A CN2012105460074 A CN 2012105460074A CN 201210546007 A CN201210546007 A CN 201210546007A CN 103028136 A CN103028136 A CN 103028136A
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China
Prior art keywords
hydrocolloid
polyisobutylene
dressing
composition
hydrocolloid dressing
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CN2012105460074A
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Chinese (zh)
Inventor
吴斌
孙云
张锐
朱思洁
张静
颜斯
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WUHAN GREENOVO BIOTECHNOLOGY Co Ltd
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WUHAN GREENOVO BIOTECHNOLOGY Co Ltd
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Priority to CN2012105460074A priority Critical patent/CN103028136A/en
Publication of CN103028136A publication Critical patent/CN103028136A/en
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Abstract

The invention provides hydrocolloid dressing and a preparation method thereof. The hydrocolloid dressing at least comprises backlining, hydrocolloid and a stripping layer, wherein the hydrocolloid is arranged on the backlining; the stripping layer is arranged on the hydrocolloid; the hydrocolloid comprises the following components in percentage by mass: 30 to 50 percent of polyisobutene, 15 to 25 percent of polycationic compound, 15 to 20 percent of polyanionic compound and 10 to 35 percent of neutral polymer; the polycationic compound consists of at least one of chitosan salt and diethyl amino ethyl glucan; the polyanionic compound consists of at least one of pectin, sodium carboxymethylcellulose, sodium alginate, carrageenin and xanthan gum; and the neutral polymer consists of at least one of gelatin, locust bean gum and guar gum. The hydrocolloid dressing can form a wet healing environment at the wound position, has a good wound healing effect and excellent water absorbency and stability, is suitable for high-leachability wounds, has excellent softness and autohension, and is convenient to use.

Description

A kind of bearing hydrocolloid dressing and preparation method thereof
Technical field
The present invention relates to a kind of dressing and preparation method thereof, particularly a kind of bearing hydrocolloid dressing and preparation method thereof.
Background technology
Bearing hydrocolloid dressing should have following features: (1) can absorb a large amount of transudates and noxious substance, also can keep certain form and intensity when moistening; (2) can keep the enough humidity of wound, reasonable resistance bacterium property and bacteriostasis are arranged; (3) more change dressings to the wound not damaged; (4) excellent storage stability has degradability, and the garbage of bearing hydrocolloid dressing does not produce pollution to environment.Bearing hydrocolloid dressing since can create moist healing environment with and the character of semipermeable membrane, particularly be widely used in the dressing at medical supplies.Compare with traditional dressing, the dressing that utilizes hydrocolloid to make has following advantage: heal comparatively fast, be convenient to medical personnel's operation, antibacterial can not see through, alleviates wound pain, reduce dressing change frequency.
Many traditional hydrocolloids are arranged in the market, and structure is by partial destruction after such hydrocolloid suction, and mechanical property significantly descends, very easily fracture, and humid stability is very poor.But in the clinical practice, the liquid seepage discharge of some common wounds is larger, fistula of operative incision surgical wound for example, but using such hydrocolloid causes splitting of dressing easily, and wound exposes, and has increased patient's misery, is unfavorable for that also medical personnel operate.Therefore, for such a large amount of exudative type wounds, the bearing hydrocolloid dressing that needs the medical worker constantly more to renew.Traditional bearing hydrocolloid dressing is in wound closure in addition, can form one deck jelly at wound, when medical worker's change dressings more, need to clear up the residual jelly of dressing, and this can cause further destruction to wound, cause wound fluid to increase, and increased medical worker's workload.
Some research work have been devoted to improve the humid stability of bearing hydrocolloid dressing at present.For example, usually improve the mechanical property of hydrocolloid and the stability after the suction by in hydrocolloid, sneaking into silicon oxide or ethylene-vinyl acetate copolymer or cross-linking dextran or cross filament.But these methods all are the water absorbing capacities by the reduction hydrocolloid, thereby improve its stability.Therefore, this class bearing hydrocolloid dressing and be not suitable for some high exudative wounds.
Summary of the invention
In order to solve the deficiencies in the prior art, it is good to the invention provides a kind of water absorption and humid stability, is fit to bearing hydrocolloid dressing of high exudative wound and preparation method thereof.
The technical solution adopted for the present invention to solve the technical problems is:
A kind of bearing hydrocolloid dressing, at least comprise backing, hydrocolloid and peel ply, hydrocolloid is arranged on the backing, peel ply is arranged on the hydrocolloid, the mass percent of each composition is in the described hydrocolloid: the shared mass fraction of polyisobutylene is 30% ~ 50%, polycationic compounds is 15% ~ 25%, and polyanionic compound is 15% ~ 20%, and neutral polymer is 10% ~ 35%; Polycationic compounds is by at least a composition the in chitosan salt and the diethyllaminoethyl glucosan, polyanionic compound is by at least a composition the in pectin, sodium carboxymethyl cellulose, sodium alginate, carrageenin and the xanthan gum, and neutral compound is by at least a composition the in gelatin, locust bean gum and the guar gum.
Preferred as such scheme, described polyisobutylene includes low-molecular-weight and high molecular weight polyisobutylene.
Described polycation is comprised of chitosan salt, and chitosan salt is the chitosan malate.
Described polyanionic compound is comprised of pectin.
Described backing is comprised of polyurethane film or non-woven fabrics.
A kind of preparation method of bearing hydrocolloid dressing as described above may further comprise the steps:
(1) preparation premixed solution: choose polyisobutylene by composition proportion, polyisobutylene includes low-molecular-weight and high molecular weight polyisobutylene, the ratio of mass fraction between the two is 4:1, low-molecular-weight and high molecular weight polyisobutylene are mixed and stirs, and obtains premixed solution;
(2) preparation premix powder: choose polycationic compounds, polyanionic compound and neutral compound by composition proportion, mix homogeneously also grinds, and obtains the premix powder;
(3) produce hydrocolloid: premix powder and premixed solution are stirred, and import the mold heated extrusion forming, obtain hydrocolloid, heating-up temperature adopts 150 ℃, and pressurization pressure is 13 ~ 14MPa;
(4) overlay film molding: adopt the step-by-step movement laminating machine to cover backing in the one side of hydrocolloid, another side covers upper peel ply, obtains bearing hydrocolloid dressing, and peel ply is release paper.
Preferred as such scheme, the molecular weight of described low-molecular-weight polyisobutylene is 10000-12000, the polyisobutene molecular weight of high molecular is 80000-100000.
The present invention than the beneficial effect that prior art has is: bearing hydrocolloid dressing provided by the invention and preparation method thereof, than traditional bearing hydrocolloid dressing, can form in the wound moist healing environment, wound is played good effect better, and its water absorption and stable state are good, be applicable to some high exudative wounds, and bearing hydrocolloid dressing has good flexibility and autohension, easy to use.
The specific embodiment
The invention will be further described below in conjunction with embodiment.
A kind of bearing hydrocolloid dressing, at least comprise backing, hydrocolloid and peel ply, hydrocolloid is arranged on the backing, peel ply is arranged on the hydrocolloid, the mass percent of each composition is in the described hydrocolloid: the shared mass fraction of polyisobutylene is 30% ~ 50%, polycationic compounds is 15% ~ 25%, and polyanionic compound is 15% ~ 20%, and neutral polymer is 10% ~ 35%; Polycationic compounds is by at least a composition the in chitosan salt and the diethyllaminoethyl glucosan, polyanionic compound is by at least a composition the in pectin, sodium carboxymethyl cellulose, sodium alginate, carrageenin and the xanthan gum, and neutral compound is by at least a composition the in gelatin, locust bean gum and the guar gum.
Preferred as such scheme, described polyisobutylene includes low-molecular-weight and high molecular weight polyisobutylene.Described polycation is comprised of chitosan salt, and chitosan salt is the chitosan malate.Described polyanionic compound is comprised of pectin.Described backing is comprised of polyurethane film or non-woven fabrics.
A kind of preparation method of bearing hydrocolloid dressing, at first prepare premixed solution: choose polyisobutylene by composition proportion, polyisobutylene includes low-molecular-weight and high molecular weight polyisobutylene, the ratio of mass fraction between the two is 4:1, low-molecular-weight and high molecular weight polyisobutylene are mixed and stir, obtain premixed solution; Next prepares the premix powder: choose polycationic compounds, polyanionic compound and neutral compound by composition proportion, mix homogeneously also grinds, and obtains the premix powder; Then produce hydrocolloid: premix powder and premixed solution are stirred, and import the mold heated extrusion forming, obtain hydrocolloid, heating-up temperature adopts 150 ℃, and pressurization pressure is 13 ~ 14MPa; Last overlay film molding: adopt the step-by-step movement laminating machine to cover backing in the one side of hydrocolloid, another side covers upper peel ply, obtains bearing hydrocolloid dressing, and peel ply is release paper.
Preferred as such scheme, the molecular weight of described low-molecular-weight polyisobutylene is 10000-12000, the polyisobutene molecular weight of high molecular is 80000-100000.
In present embodiment 1, at first prepare premixed solution: choose low-molecular-weight polyisobutylene 3.2 ㎏ by composition proportion, high molecular weight polyisobutylene 0.8 ㎏ mixes low-molecular-weight and high molecular weight polyisobutylene and stirs, and obtains premixed solution; Next prepares the premix powder: choose polycationic compounds chitosan malate 2.0 ㎏, polyanionic compound pectin 2.0 ㎏ and neutral compound guar gum 2.0 ㎏ by composition proportion, mix homogeneously also grinds, and obtains the premix powder; Then produce hydrocolloid: premix powder and premixed solution are stirred, and import the mold heated extrusion forming, obtain hydrocolloid, heating-up temperature adopts 150 ℃, and pressurization pressure is 13.7MPa; Last overlay film molding: adopt the step-by-step movement laminating machine to cover backing in the one side of hydrocolloid, another side covers upper peel ply, obtains bearing hydrocolloid dressing A, and peel ply is release paper.
In present embodiment 2, at first prepare premixed solution: choose low-molecular-weight polyisobutylene 3.2 ㎏ by composition proportion, high molecular weight polyisobutylene 0.8 ㎏ mixes low-molecular-weight and high molecular weight polyisobutylene and stirs, and obtains premixed solution; Next prepares the premix powder: choose polycationic compounds chitosan malate 2.0 ㎏, polyanionic compound pectin 2.0 ㎏ and neutral compound gelatin 2.0 ㎏ by composition proportion, mix homogeneously also grinds, and obtains the premix powder; Then produce hydrocolloid: premix powder and premixed solution are stirred, and import the mold heated extrusion forming, obtain hydrocolloid, heating-up temperature adopts 150 ℃, and pressurization pressure is 13.7MPa; Last overlay film molding: adopt the step-by-step movement laminating machine to cover backing in the one side of hydrocolloid, another side covers upper peel ply, obtains bearing hydrocolloid dressing B, and peel ply is release paper.
In present embodiment 3, at first prepare premixed solution: choose low-molecular-weight polyisobutylene 3.2 ㎏ by composition proportion, high molecular weight polyisobutylene 0.8 ㎏ mixes low-molecular-weight and high molecular weight polyisobutylene and stirs, and obtains premixed solution; Next prepares the premix powder: choose polycationic compounds chitosan malate 2.0 ㎏, polyanionic compound sodium carboxymethyl cellulose 2.0 ㎏ and neutral compound gelatin 2.0 ㎏ by composition proportion, mix homogeneously also grinds, and obtains the premix powder; Then produce hydrocolloid: premix powder and premixed solution are stirred, and import the mold heated extrusion forming, obtain hydrocolloid, heating-up temperature adopts 150 ℃, and pressurization pressure is 13.7MPa; Last overlay film molding: adopt the step-by-step movement laminating machine to cover backing in the one side of hydrocolloid, another side covers upper peel ply, obtains bearing hydrocolloid dressing D, and peel ply is release paper.
In present embodiment 4, at first prepare premixed solution: choose low-molecular-weight polyisobutylene 3.2 ㎏ by composition proportion, high molecular weight polyisobutylene 0.8 ㎏ mixes low-molecular-weight and high molecular weight polyisobutylene and stirs, and obtains premixed solution; Next prepares the premix powder: choose polycationic compounds chitosan glutamate salt 2.0 ㎏, polyanionic compound sodium carboxymethyl cellulose 2.0 ㎏ and neutral compound gelatin 2.0 ㎏ by composition proportion, mix homogeneously also grinds, and obtains the premix powder; Then produce hydrocolloid: premix powder and premixed solution are stirred, and import the mold heated extrusion forming, obtain hydrocolloid, heating-up temperature adopts 150 ℃, and pressurization pressure is 13.7MPa; Last overlay film molding: adopt the step-by-step movement laminating machine to cover backing in the one side of hydrocolloid, another side covers upper peel ply, obtains bearing hydrocolloid dressing C, and peel ply is release paper.
In present embodiment 5, at first prepare premixed solution: choose low-molecular-weight polyisobutylene 3.2 ㎏ by composition proportion, high molecular weight polyisobutylene 0.8 ㎏ mixes low-molecular-weight and high molecular weight polyisobutylene and stirs, and obtains premixed solution; Next prepares the premix powder: choose polycationic compounds chitosan glutamate salt 2.0 ㎏, polyanionic compound sodium alginate 2.0 ㎏ and neutral compound gelatin 2.0 ㎏ by composition proportion, mix homogeneously also grinds, and obtains the premix powder; Then produce hydrocolloid: premix powder and premixed solution are stirred, and import the mold heated extrusion forming, obtain hydrocolloid, heating-up temperature adopts 150 ℃, and pressurization pressure is 13.7MPa; Last overlay film molding: adopt the step-by-step movement laminating machine to cover backing in the one side of hydrocolloid, another side covers upper peel ply, obtains bearing hydrocolloid dressing E, and peel ply is release paper..
In present embodiment 6, at first prepare premixed solution: choose low-molecular-weight polyisobutylene 3.2 ㎏ by composition proportion, high molecular weight polyisobutylene 0.8 ㎏ mixes low-molecular-weight and high molecular weight polyisobutylene and stirs, and obtains premixed solution; Next prepares the premix powder: choose polycationic compounds chitosan glutamate salt 2.0 ㎏, polyanionic compound carrageenin 2.0 ㎏ and neutral compound guar gum 2.0 ㎏ by composition proportion, mix homogeneously also grinds, and obtains the premix powder; Then produce hydrocolloid: premix powder and premixed solution are stirred, and import the mold heated extrusion forming, obtain hydrocolloid, heating-up temperature adopts 150 ℃, and pressurization pressure is 13.7MPa; Last overlay film molding: adopt the step-by-step movement laminating machine to cover backing in the one side of hydrocolloid, another side covers upper peel ply, obtains bearing hydrocolloid dressing F, and peel ply is release paper.
The humid stability of the hydrocolloid of the bearing hydrocolloid dressing A ~ F that makes for above-described embodiment 1 ~ 6 and water absorption are measured, and assay method is as follows:
Humid stability is measured: the hydrocolloid to be tested of choosing area and be 2.5 ㎝ *, 2.5 ㎝ is weighed, and institute weighs and is designated as W 1, the hydrocolloid to be tested of finishing weighing joins and is equipped with in the centrifuge tube of phosphate buffer that pH value is 7.4 40ml; Then centrifuge tube is rotated 18h with 50z/min, obtain sample.At last sample is weighed behind the dry 6h in the drying baker of 80 ℃ of constant temperature and constant humidity 10%, institute weighs and is designated as W 2
Humid stability is calculated as follows equation: humid stability=W 2/ W 1* 100.
Water absorption is measured: the hydrocolloid to be tested of choosing area and be 2.5 ㎝ *, 2.5 ㎝ is weighed, and institute weighs and is designated as W 3, the hydrocolloid to be tested of finishing weighing joins and is equipped with in the centrifuge tube of phosphate buffer that pH value is 7.4 40ml; Then centrifuge tube is left standstill 24h, obtain sample.With samples weighing, institute weighs and is designated as W at last 4
Water absorption is calculated as follows equation: water absorption=W 4/ W 3* 100.
The hydrocolloid humid stability of dressing A-F of the present invention and water absorption test result are as showing-1:
Table-1

Claims (7)

1. bearing hydrocolloid dressing, it is characterized in that: comprise at least backing, hydrocolloid and peel ply, hydrocolloid is arranged on the backing, peel ply is arranged on the hydrocolloid, the mass percent of each composition is in the described hydrocolloid: the shared mass fraction of polyisobutylene is 30% ~ 50%, polycationic compounds is 15% ~ 25%, and polyanionic compound is 15% ~ 20%, and neutral polymer is 10% ~ 35%; Polycationic compounds is by at least a composition the in chitosan salt and the diethyllaminoethyl glucosan, polyanionic compound is by at least a composition the in pectin, sodium carboxymethyl cellulose, sodium alginate, carrageenin and the xanthan gum, and neutral compound is by at least a composition the in gelatin, locust bean gum and the guar gum.
2. bearing hydrocolloid dressing according to claim 1, it is characterized in that: described polyisobutylene includes low-molecular-weight and high molecular weight polyisobutylene.
3. bearing hydrocolloid dressing according to claim 1, it is characterized in that: described polycation is comprised of chitosan salt, and chitosan salt is the chitosan malate.
4. bearing hydrocolloid dressing according to claim 1, it is characterized in that: described polyanionic compound is comprised of pectin.
5. bearing hydrocolloid dressing according to claim 1, it is characterized in that: described backing is comprised of polyurethane film or non-woven fabrics.
6. the preparation method of a bearing hydrocolloid dressing as claimed in claim 1 is characterized in that may further comprise the steps:
(1) preparation premixed solution: choose polyisobutylene by composition proportion, polyisobutylene includes low-molecular-weight and high molecular weight polyisobutylene, the ratio of mass fraction between the two is 4:1, low-molecular-weight and high molecular weight polyisobutylene are mixed and stirs, and obtains premixed solution;
(2) preparation premix powder: choose polycationic compounds, polyanionic compound and neutral compound by composition proportion, mix homogeneously also grinds, and obtains the premix powder;
(3) produce hydrocolloid: premix powder and premixed solution are stirred, and import the mold heated extrusion forming, obtain hydrocolloid, heating-up temperature adopts 150 ℃, and pressurization pressure is 13 ~ 14MPa;
(4) overlay film molding: adopt the step-by-step movement laminating machine to cover backing in the one side of hydrocolloid, another side covers upper peel ply, obtains bearing hydrocolloid dressing, and peel ply is release paper.
7. preparation method according to claim 6, it is characterized in that: the molecular weight of described low-molecular-weight polyisobutylene is 10000-12000, the polyisobutene molecular weight of high molecular is 80000-100000.
CN2012105460074A 2012-12-14 2012-12-14 Hydrocolloid dressing and preparation method thereof Pending CN103028136A (en)

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Cited By (10)

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Publication number Priority date Publication date Assignee Title
CN103623457A (en) * 2013-12-09 2014-03-12 长春吉原生物科技有限公司 Special-shaped hydrogel functional dressing and preparation method thereof
CN104784741A (en) * 2015-04-23 2015-07-22 武汉市思泰利医疗器械发展有限公司 Functional medical dressing containing chitosan and hydrocolloid
CN104874014A (en) * 2015-05-22 2015-09-02 苏州市贝克生物科技有限公司 Preparation method of medical hemostatic occlusion dressing
CN104906625A (en) * 2015-05-22 2015-09-16 苏州市贝克生物科技有限公司 Method for preparing medical hydrogel
CN105288709A (en) * 2015-11-05 2016-02-03 上海典范医疗科技有限公司 Wet wound dressing and preparation method thereof
CN105833329A (en) * 2015-12-21 2016-08-10 马盟 Hydrocolloid dressing and preparation method thereof
CN106039382A (en) * 2016-05-25 2016-10-26 东华大学 Glucan-based transparent hydrogel dressing and preparation method thereof
CN108774874A (en) * 2018-06-25 2018-11-09 合肥中科卫云健康科技有限公司 A kind of preparation method of the hydrophilic nonwoven polypropylene fabric material containing nano silver
CN109276743A (en) * 2018-11-08 2019-01-29 广州润虹医药科技股份有限公司 A kind of fast-acting nemostatic yarn and its preparation method and application promoting wound healing
CN114306720A (en) * 2022-01-04 2022-04-12 武汉同向医疗器械有限公司 Wound dressing containing aloe gel and preparation method thereof

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CN101370530A (en) * 2006-01-18 2009-02-18 科洛普拉斯特公司 Layered adhesive construction with adhesive layers having different hydrocolloid composition
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Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103623457A (en) * 2013-12-09 2014-03-12 长春吉原生物科技有限公司 Special-shaped hydrogel functional dressing and preparation method thereof
CN104784741A (en) * 2015-04-23 2015-07-22 武汉市思泰利医疗器械发展有限公司 Functional medical dressing containing chitosan and hydrocolloid
CN104874014A (en) * 2015-05-22 2015-09-02 苏州市贝克生物科技有限公司 Preparation method of medical hemostatic occlusion dressing
CN104906625A (en) * 2015-05-22 2015-09-16 苏州市贝克生物科技有限公司 Method for preparing medical hydrogel
CN105288709B (en) * 2015-11-05 2018-05-22 上海典范医疗科技有限公司 wet wound dressing and preparation method thereof
CN105288709A (en) * 2015-11-05 2016-02-03 上海典范医疗科技有限公司 Wet wound dressing and preparation method thereof
CN105833329A (en) * 2015-12-21 2016-08-10 马盟 Hydrocolloid dressing and preparation method thereof
CN106039382A (en) * 2016-05-25 2016-10-26 东华大学 Glucan-based transparent hydrogel dressing and preparation method thereof
CN108774874A (en) * 2018-06-25 2018-11-09 合肥中科卫云健康科技有限公司 A kind of preparation method of the hydrophilic nonwoven polypropylene fabric material containing nano silver
CN108774874B (en) * 2018-06-25 2020-11-03 合肥中科卫云健康科技有限公司 Preparation method of nano-silver-containing hydrophilic polypropylene fiber non-woven fabric
CN109276743A (en) * 2018-11-08 2019-01-29 广州润虹医药科技股份有限公司 A kind of fast-acting nemostatic yarn and its preparation method and application promoting wound healing
CN109276743B (en) * 2018-11-08 2021-07-27 广州润虹医药科技股份有限公司 Quick-acting hemostatic yarn for promoting wound healing and preparation method and application thereof
CN114306720A (en) * 2022-01-04 2022-04-12 武汉同向医疗器械有限公司 Wound dressing containing aloe gel and preparation method thereof

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Application publication date: 20130410