CN103027763A - Vena cava filter coated with macromolecular coating and preparation method for macromolecular coating - Google Patents
Vena cava filter coated with macromolecular coating and preparation method for macromolecular coating Download PDFInfo
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- CN103027763A CN103027763A CN2012104645942A CN201210464594A CN103027763A CN 103027763 A CN103027763 A CN 103027763A CN 2012104645942 A CN2012104645942 A CN 2012104645942A CN 201210464594 A CN201210464594 A CN 201210464594A CN 103027763 A CN103027763 A CN 103027763A
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Abstract
The invention provides a vena cava filter coated with a macromolecular coating and a preparation method for the macromolecular coating. A recycling part, a pre-filtering part, a supporting part, an anti-shifting part and a filtering capturing part are all formed by cutting a same memory alloy material through laser; the filtering capturing part is characterized in that six V-shaped rods stretch out from a closed annular structure in a parallel form, the structure is equally divided by the V-shaped rods and is rotated, and a branch end is connected with a supporting part, so that a conical netted structure is formed; and the surface layers of the recycling part, the pre-filtering part, the supporting part, the anti-shifting part and the filtering capturing part are all coated with the macromolecular coatings. A metal filter provided by the invention adopts the unique hexahedral column structural design, so that the metal filter has excellent adherence property and is easier to recycle; the endothelialization process after the filter is planted into a vena cava vessel is effectively slowed down and the internal planting time of the filter is prolonged by the macromolecular coating; and the difficulty in recycling the filter is relieved and the harm to the vena cava of a patient caused by a recycling stage is reduced.
Description
Technical field
The present invention relates to a kind of preparation method that is covered with vena cava filter and the polymeric coating layer of polymeric coating layer, belong to vena cava filter and coating production technical field.
Background technology
Oneself becomes the commonly encountered diseases of harm humans health venous thrombosis, and sickness rate rises year by year, and important complication is that thrombosis comes off repeatedly, causes pulmonary embolism or pulmonary infarction, and mortality rate is high, seriously jeopardizes patient's life.Adopt traditional operation treatment, wound face is larger, dangerous large, adopted in recent years interventional therapy, it is to adopt the method for percutaneous puncture that the percutaneous IVCF is put art, by the conduit carrier, places the metal filter at postcava, filter can stop thrombosis up, prevention or minimizing pulmonary thromboembolism.Compare with traditional surgical operation, the percutaneous IVCF is put art simply, safely, effectively, is widely adopted in recent years.
Existing recyclable filter possibly can't reclaim smoothly owing to reasons such as tissue adhesion, blood vessel endotheliums; If reclaim by force, the complication such as may cause that caval vein is torn.
Existing not recyclable filter is along with the lengthening of Implantation Time, thrombosis or IVCF itself that the spreading of far-end thrombosis, IVCF catch bring out as human body foreign body, eventually to involving whole postcava tube chamber, cause the severe complications such as local thrombus formation, inferior vena cava obstruction, this type of filter causes that having the symptom caval vein to block incidence rate is 2% ~ 10%, and asymptomatic caval vein blocks incidence rate up to 30%.
Summary of the invention
The objective of the invention is the problem that can't reclaim smoothly owing to reasons such as tissue adhesion, blood vessel endotheliums in order to solve existing recyclable filter, and then a kind of preparation method that is covered with vena cava filter and the polymeric coating layer of polymeric coating layer is provided.
The objective of the invention is to be achieved through the following technical solutions:
A kind of vena cava filter that is covered with polymeric coating layer, comprise: recoverer, pre-filtering section, the support portion, anti-displacement portion, filter capture unit and polymeric coating layer, described recoverer, pre-filtering section, the support portion, anti-displacement portion and filtration capture unit all are to be formed by same memory alloy material cut, described filtration capture unit is stretched out six V shape poles by the circulus of a closure is parallel, with minute rotations such as V shape poles, the branch end is connected with the support portion, form the network structure of the conical surface, described filtration capture unit is petal for dividing equally hexagonal, the bifurcated that filters capture unit V shape pole end interconnects to intersect and extends parallel six roots of sensation support column, namely consisted of the support portion, be connected in the other end of support portion with the pre-filtering section of filtering the capture unit symmetrical configuration, end is recoverer in pre-filtering section, described recoverer, pre-filtering section, the support portion, the Surface mulch of anti-displacement portion and filtration capture unit has polymeric coating layer.
The preparation method of polymeric coating layer: choose mass fraction and be the first polymer of 50 ~ 95% and mass fraction and be 5 ~ 50% second polymer, described the first polymer and second polymer all are dissolved in N, dinethylformamide, N-Methyl pyrrolidone, in oxolane or the acetone, with the even dip-coating of completely reacted copolymer at recoverer 1, pre-filtering section 2, support portion 3, on the top layer of anti-displacement portion 4 and filtration capture unit 5, and in 55 ~ 65 ℃ baking oven dry 2 ~ 4 hours, then under<100mm mercury column vacuum condition, dried by the fire 2.5 ~ 3.5 hours, obtain white foam shape thin film; Then reheat to 170 ~ 180 ℃ form the layer of transparent adhesive film on the top layer; Namely form ganoine thin film after cooling.
The invention has the beneficial effects as follows that metallic filter, more easily reclaims so that it has good adherent property by unique hexahedro rod structure design.Be covered with polymeric coating layer on the metallic filter surface, this polymeric coating layer can effectively slow down the process of filter endothelialization behind the implant cavity vein blood vessel, increases filter Implantation Time in vivo; Prevent the generation of blood vessel endothelium, can alleviate the difficulty that reclaims filter, reduced the damage that recovery stage brings to patient's caval vein; Can effectively prevent local thrombus obstruction, inferior vena cava obstruction and complication thereof.
Description of drawings
A kind of structural representation that is covered with the vena cava filter of polymeric coating layer that Fig. 1 provides for the specific embodiment of the present invention;
Fig. 2 is that the integral body of filter is overlooked design sketch;
Fig. 3 is the generalized section of filter.
Fig. 4 is the implantation design sketch of filter.
The specific embodiment
The present invention is described in further detail below in conjunction with accompanying drawing: present embodiment is implemented under take technical solution of the present invention as prerequisite, has provided detailed embodiment, but protection scope of the present invention is not limited to following embodiment.
Such as Fig. 1 ~ shown in Figure 3, a kind of vena cava filter that is covered with polymeric coating layer that present embodiment is related, comprise: recoverer 1, pre-filtering section 2, support portion 3, anti-displacement portion 4, filter capture unit 5 and polymeric coating layer 6, described recoverer 1, pre-filtering section 2, support portion 3, anti-displacement portion 4 and filtration capture unit 5 all are to be formed by same memory alloy material cut, described filtration capture unit 5 is stretched out six V shape poles by the circulus of a closure is parallel, with minute rotations such as V shape poles, the branch end is connected with support portion 3, form the network structure of the conical surface, described filtration capture unit 5 is overlooked effect for dividing equally hexagonal petal effect.The bifurcated that filters capture unit 5 V shape pole ends interconnects to intersect and extends parallel six roots of sensation support column, namely consisted of support portion 3, be connected in the other end of support portion 3 with the pre-filtering section 2 of filtering capture unit 5 symmetrical configuration, are recoverers 1 at pre-filtering section 2 ends, described recoverer 1, pre-filtering section 2, support portion 3, anti-displacement portion 4 and the Surface mulch that filters capture unit 5 have polymeric coating layer 6.
The thickness of described polymeric coating layer 6 is between 1 μ m ~ 100 μ m.
The thickness of described polymeric coating layer 6 is 10 μ m.
The memory alloy material of described making recoverer 1, pre-filtering section 2, support portion 3, anti-displacement portion 4 and filtration capture unit 5 is rustless steel or cochrome or Nitinol.
Described filter integral body is spindle, and the filter two ends are closing-in structure, and petal into five equilibrium overlooked at two ends.
The preparation method of described polymeric coating layer 6: choose mass fraction and be the first polymer of 50 ~ 95% and mass fraction and be 5 ~ 50% second polymer, described the first polymer and second polymer all are dissolved in N, dinethylformamide, N-Methyl pyrrolidone, in oxolane or the acetone, with the even dip-coating of completely reacted copolymer at recoverer 1, pre-filtering section 2, support portion 3, on the top layer of anti-displacement portion 4 and filtration capture unit 5, and in 55 ~ 65 ℃ baking oven dry 2 ~ 4 hours, then under<100mm mercury column vacuum condition, dried by the fire 2.5 ~ 3.5 hours, obtain white foam shape thin film; Then reheat to 170 ~ 180 ℃ form the layer of transparent adhesive film on the top layer; Namely form ganoine thin film after cooling.
Described the first polymer is vinylidene, and described second polymer is hexafluoropropene, tetrafluoroethene, 1-hydrogen five fluorine propylene, perfluor (methyl vinyl ether), CTFE, five fluorine propylene, trifluoro-ethylene, Hexafluoro acetone or hexafluoro-isobutene.
The mass fraction of described the first polymer is 51 ~ 94%, and the mass fraction of second polymer is 6 ~ 49%.
The mass fraction of described the first polymer is 55%, and the mass fraction of second polymer is 45%.
The mass fraction of described the first polymer is 90%, and the mass fraction of second polymer is 10%.
The thickness of described polymeric coating layer 6 is between 1 μ m ~ 100 μ m.
Described macromolecular material is a kind of macromolecular material that shows inertia, and it mainly is fluorinated copolymer.This type coating can provide an inactive surfaces that contacts with mammal soma effectively at the amount on the device when device is transplanted into mammal, and contain a kind of film forming fluorinated copolymer, copolymer comprises the copolymer of first's polymerizate and second portion polymerizate, and wherein the relative amount of first and second portion polymerizate can make coating and thin film have the performance that can be effectively used to be coated with the transplantation medical device effectively.
As shown in Figure 2, the first from left width of cloth is a kind of whole side-looking design sketch that is covered with the vena cava filter of polymeric coating layer, and a right width of cloth is to divide equally hexagonal petal form to be the design sketch of overlooking of this filter.
As shown in Figure 3, be the coverage effect profile of polymeric coating layer.
As shown in Figure 4, be the vena cava filter implant cavity vein that is covered with polymeric coating layer, stop and catch the design sketch of thrombi.
The present invention adopts that marmem pipe material cutting is one-body molded can be compressed among the delivery sheath, be transported to the caval vein calibration position, self-expanding is adherent in caval vein after discharging, and finishes and implants all after dates, cooperates with catcher filter drawn in recovery sheath pipe by recoverer and takes out.
The above; only be the better specific embodiment of the present invention; these specific embodiment all are based on the different implementations under the general idea of the present invention; and protection scope of the present invention is not limited to this; anyly be familiar with those skilled in the art in the technical scope that the present invention discloses; the variation that can expect easily or replacement all should be encompassed within protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claims.
Claims (10)
1. vena cava filter that is covered with polymeric coating layer, it is characterized in that, comprise: recoverer, pre-filtering section, the support portion, anti-displacement portion, filter capture unit and polymeric coating layer, described recoverer, pre-filtering section, the support portion, anti-displacement portion and filtration capture unit all are to be formed by same memory alloy material cut, described filtration capture unit is stretched out six V shape poles by the circulus of a closure is parallel, with minute rotations such as V shape poles, the branch end is connected with the support portion, form the network structure of the conical surface, described filtration capture unit is petal for dividing equally hexagonal, the bifurcated that filters capture unit V shape pole end interconnects to intersect and extends parallel six roots of sensation support column, namely consisted of the support portion, be connected in the other end of support portion with the pre-filtering section of filtering the capture unit symmetrical configuration, end is recoverer in pre-filtering section, described recoverer, pre-filtering section, the support portion, the Surface mulch of anti-displacement portion and filtration capture unit has polymeric coating layer.
2. the vena cava filter that is covered with polymeric coating layer according to claim 1 is characterized in that, the thickness of described polymeric coating layer is 1 μ m ~ 100 μ m.
3. the vena cava filter that is covered with polymeric coating layer according to claim 2 is characterized in that, the thickness of described polymeric coating layer is 10 μ m.
4. the vena cava filter that is covered with polymeric coating layer according to claim 1 is characterized in that, the memory alloy material of described making recoverer, pre-filtering section, support portion, anti-displacement portion and filtration capture unit is rustless steel, cochrome or Nitinol.
5. the preparation method of the described polymeric coating layer of claim 1: it is characterized in that, choose mass fraction and be the first polymer of 50 ~ 95% and mass fraction and be 5 ~ 50% second polymer, described the first polymer and second polymer all are dissolved in N, dinethylformamide, N-Methyl pyrrolidone, in oxolane or the acetone, with the even dip-coating of completely reacted copolymer at recoverer 1, pre-filtering section 2, support portion 3, on the top layer of anti-displacement portion 4 and filtration capture unit 5, and in 55 ~ 65 ℃ baking oven dry 2 ~ 4 hours, then under<100mm mercury column vacuum condition, dried by the fire 2.5 ~ 3.5 hours, obtain white foam shape thin film; Then reheat to 170 ~ 180 ℃ form the layer of transparent adhesive film on the top layer; Namely form ganoine thin film after cooling.
6. the preparation method of polymeric coating layer according to claim 5: it is characterized in that, described the first polymer is vinylidene, and described second polymer is hexafluoropropene, tetrafluoroethene, 1-hydrogen five fluorine propylene, perfluor (methyl vinyl ether), CTFE, five fluorine propylene, trifluoro-ethylene, Hexafluoro acetone or hexafluoro-isobutene.
7. the preparation method of polymeric coating layer according to claim 5: it is characterized in that the mass fraction of described the first polymer is 51 ~ 94%, the mass fraction of second polymer is 6 ~ 49%.
8. the preparation method of polymeric coating layer according to claim 5: it is characterized in that the mass fraction of described the first polymer is 55%, the mass fraction of second polymer is 45%.
9. the preparation method of polymeric coating layer according to claim 5: it is characterized in that the mass fraction of described the first polymer is 90%, the mass fraction of second polymer is 10%.
10. the preparation method of polymeric coating layer according to claim 5: it is characterized in that the thickness of described polymeric coating layer is between 1 μ m ~ 100 μ m.
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104352287A (en) * | 2014-10-13 | 2015-02-18 | 陈奕龙 | Vena cava filter |
CN104970900A (en) * | 2015-06-26 | 2015-10-14 | 深圳市科奕顿生物医疗科技有限公司 | Filter capable of recycling thrombi |
CN106310392A (en) * | 2015-07-09 | 2017-01-11 | 首都医科大学附属北京世纪坛医院 | Coating solution, recoverable vena cava filter and preparation method thereof |
CN106308974A (en) * | 2015-06-30 | 2017-01-11 | 先健科技(深圳)有限公司 | Filter |
CN106491238A (en) * | 2015-09-07 | 2017-03-15 | 微创心脉医疗科技(上海)有限公司 | Filter unit |
CN107174386A (en) * | 2017-04-27 | 2017-09-19 | 广州启骏生物科技有限公司 | A kind of device for treating pulmonary hypertension |
WO2020062331A1 (en) * | 2018-09-26 | 2020-04-02 | 李雷 | Vena cava embolic filter |
CN111839806A (en) * | 2020-07-31 | 2020-10-30 | 上海心玮医疗科技有限公司 | High-compliance plug protector and filter screen manufacturing method thereof |
US10939986B2 (en) | 2016-04-28 | 2021-03-09 | Shenzhen Kyd Biomedical Tehcnology Co. Ltd. | Inferior vena cava filter |
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CN2486128Y (en) * | 2001-06-13 | 2002-04-17 | 徐林 | vena cava filter |
CN2569770Y (en) * | 2002-09-28 | 2003-09-03 | 维科医疗器械(苏州)有限公司 | Recoverable thrombus filter |
CN1669537A (en) * | 2003-12-19 | 2005-09-21 | 科迪斯公司 | Local vascular delivery of trichostatin A alone or in combination with sirolimus to prevent restenosis following vascular injury |
CN101843531A (en) * | 2010-05-25 | 2010-09-29 | 天健医疗科技(苏州)有限公司 | Medicament coated thrombus filter |
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CN2486128Y (en) * | 2001-06-13 | 2002-04-17 | 徐林 | vena cava filter |
CN2569770Y (en) * | 2002-09-28 | 2003-09-03 | 维科医疗器械(苏州)有限公司 | Recoverable thrombus filter |
CN1669537A (en) * | 2003-12-19 | 2005-09-21 | 科迪斯公司 | Local vascular delivery of trichostatin A alone or in combination with sirolimus to prevent restenosis following vascular injury |
CN101843531A (en) * | 2010-05-25 | 2010-09-29 | 天健医疗科技(苏州)有限公司 | Medicament coated thrombus filter |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104352287A (en) * | 2014-10-13 | 2015-02-18 | 陈奕龙 | Vena cava filter |
CN104352287B (en) * | 2014-10-13 | 2016-09-07 | 深圳市科奕顿生物医疗科技有限公司 | Vena cava filter |
CN104970900A (en) * | 2015-06-26 | 2015-10-14 | 深圳市科奕顿生物医疗科技有限公司 | Filter capable of recycling thrombi |
CN104970900B (en) * | 2015-06-26 | 2017-10-17 | 深圳市科奕顿生物医疗科技有限公司 | Recyclable thrombus filter |
CN106308974A (en) * | 2015-06-30 | 2017-01-11 | 先健科技(深圳)有限公司 | Filter |
CN106308974B (en) * | 2015-06-30 | 2018-08-03 | 先健科技(深圳)有限公司 | Filter |
CN106310392A (en) * | 2015-07-09 | 2017-01-11 | 首都医科大学附属北京世纪坛医院 | Coating solution, recoverable vena cava filter and preparation method thereof |
CN106491238A (en) * | 2015-09-07 | 2017-03-15 | 微创心脉医疗科技(上海)有限公司 | Filter unit |
US10939986B2 (en) | 2016-04-28 | 2021-03-09 | Shenzhen Kyd Biomedical Tehcnology Co. Ltd. | Inferior vena cava filter |
CN107174386A (en) * | 2017-04-27 | 2017-09-19 | 广州启骏生物科技有限公司 | A kind of device for treating pulmonary hypertension |
WO2020062331A1 (en) * | 2018-09-26 | 2020-04-02 | 李雷 | Vena cava embolic filter |
CN111839806A (en) * | 2020-07-31 | 2020-10-30 | 上海心玮医疗科技有限公司 | High-compliance plug protector and filter screen manufacturing method thereof |
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Application publication date: 20130410 |