CN103027231A

CN103027231A - Compound probiotics fermented Chinese herbal medicine active health care liquid and preparation method thereof

Info

Publication number: CN103027231A
Application number: CN2013100002892A
Authority: CN
Inventors: 蒋常德; 胡艳晖; 蒋芝诺
Original assignee: Individual
Current assignee: Hunan Modern Resource Biotechnology Co ltd
Priority date: 2013-01-01
Filing date: 2013-01-01
Publication date: 2013-04-10
Anticipated expiration: 2033-01-01
Also published as: CN103027231B

Abstract

The invention provides compound probiotics fermented Chinese herbal medicine active health care liquid and a preparation method thereof. The health care liquid is prepared by the following raw materials: folium ginkgo, gingko pollen, fructus lycii, tea leaves, bacillus natto, saccharomyces cerevisiae, lactobacilli, acetobacter xylinum, bifidobactirium, white granulated sugar, brown sugar, defatted soy flour, honey, oligosaccharide, sodium chloride, deionized water and the like. The compound probiotics fermented Chinese herbal medicine active health care liquid integrates disease treatment and health care functions of several single products, contains Chinese herbal medicine active ingredients with the functions of preventing and treating hyperlipidemia, hyperglycemia and hypertension, preventing tumors and cancers, enhancing memory, protecting livers, improving immunity, preventing and treating coronary heart diseases, and also contains probiotics groups and metabolic products of the probiotics groups which can regulate balance in the stomach and intestines, resist aging, prolong the life, facilitate digestion, expel toxin for beauty, and prevent and treat thrombi, constipation and diarrhea. The health care liquid integrates health care and treatment, is very wide in market prospect, and conforms to the existing medical viewpoint of people that the prevention, health care, treatment and recovery are combined.

Description

A kind of composite probiotics ferment Chinese herbal medicine active health liquid and preparation method thereof

Technical field

The invention belongs to probio biological medicine health product technology field, be specifically related to a kind of composite probiotics ferment Chinese herbal medicine active health liquid and preparation method thereof.

Background technology

Modern society, people's material life has had very large change, overnutrition, do not get enough athletic exercise, operating pressure is large, environmental pollution causes people's health sub-health state to occur, be added into too much anticorrisive agent in the food that we take in every day, pigment, essence, also has residual agricultural chemicals, veterinary drug, the harmful substances such as hormone, and antibiotic abuse, cause the interior beneficial bacterium of our body in continuous minimizing, and harmful bacteria is in continuous increase, produce and accumulated a large amount of toxin, thereby All kinds of diseases and ailments break out to cause human body, tumour, cancer, hypertension, high fat of blood, hyperglycaemia, coronary heart disease, cerebral thrombus, the incidence of disease of the diseases such as enterogastritis is more and more higher, change the state of an illness by a large amount of drug administrations, often cure the symptoms, not the disease, long-term prescription can produce very large side effect, and the patient produces dependence to medicine in the course of time, this not only increases the life spending, also can cause organ to be damaged because of long-term prescription.

Chinese medicine originates from China, the history in existing thousands of years, it is the summary of experience that ancient times, the working people fought back the disease, the effect that the various active materials of Chinese medicine play preventing and treating diseases is proved by practice, Chinese herbal medicine is to the long action time of preventing and curing diseases, but the problems such as existence takes effect slow, and effect is unstable, and Chinese herbal medicine active ingredient utilization rate is low.

The traditional Chinese medicine that China is traditional combines with biotechnology, directly utilize the beneficial flora fermentation of Chinese herbal medicine, can destroy the cell membrane of Chinese herbal medicine, greatly improve the utilization rate of the effective ingredient of Chinese herbal medicine, and produce during the fermentation multiple somatomedin and new active material, can play the drug effect that improves Chinese herbal medicine, accelerate the speed that takes effect, reduce the consumption of Chinese herbal medicine.

At present, the theory of " with bacterium bacterium processed; eliminate vivotoxin; the balance bacterium gets healthy " is proposed in the world, real health comes from the balance of little ecology in the human body, wherein the quantity of profitable strain and pernicious bacteria is being maintained the balance of the little ecology of human body, colony balance all has positive effect to the nutritional status of human body, physiological function, bacterium infection, drug effect, toxin reaction, immune response, aging course etc., Given this, people begin to seek can diseases prevention, cure the disease, and does not produce again the health products of the medicine-food two-purpose of toxic and side effect.

Summary of the invention

The objective of the invention is for the deficiencies in the prior art, biotechnology and Chinese Chinese traditional herbs technology are combined, provide that a kind of complex probiotics viable bacteria content is high, the vegetable Chinese herbal medicine material usage is few, active high, stability is high, action effect is fast, have reducing blood lipid, hypotensive, prevent and treat coronary heart disease, antitumor, anti-cancer, radioresistance, the memory of improving, liver protecting, anti-ageing, promote longevity, aid digestion, toxin-expelling and face nourishing, excitor nerve, cardiac stimulant expander, excited breathing, diuresis, prevent and treat the Chinese herbal medicine active fermentation health promoting liquid of the effects such as diabetes.

Another object of the present invention provides the preparation method of this composite probiotics ferment Chinese herbal medicine active health liquid.

To achieve these goals, the technical solution used in the present invention is: a kind of composite probiotics ferment Chinese herbal medicine active health liquid is characterized in that the raw material for preparing this health promoting liquid is by weight: gingko pollen 1-3 part, matrimony vine 4-20 part, ginkgo leaf 5-20 part, tealeaves 2-10 part, bafillus natto 10-20 part, saccharomyces cerevisiae 10-40 part, lactobacillus 5-15 part, acetobacter xylinum 5-10 part, Bifidobacterium 10-20 part, white granulated sugar 20-40 part, brown sugar 10-40 part, defatted soy flour 10-20 part, honey 10-20 part, compound sugar 2-10 part, sodium chloride 2-4 part, 800 parts of deionized waters.

In order to achieve the above object, composite probiotics ferment Chinese herbal medicine active health liquid of the present invention and preparation method thereof comprises the steps:

⑴ the preliminary treatment of, ginkgo leaf: 5-20 part ginkgo leaf powder is broken to the 20-40 order, and deionized water 60 degree that add 20 times were precooked 5 minutes, dewatered with 8 layers of filtered through gauze;

⑵, in fermentation tank, add through pretreated ginkgo leaf powder, adds 800 parts of deionized waters, after 100 degree are incubated 30 minutes, add matrimony vine 4-20 part, tealeaves 2-10 part, white granulated sugar 20-40 part, brown sugar 10-40 part, honey 10-20 part, defatted soy flour 10-20 part, compound sugar 2-10 part, sodium chloride 2-4 part is incubated 20 minutes behind the mixing again under 100 degree, then be cooled to 80 degree, add gingko pollen 1-3 part, be incubated 20 minutes, be down to rapidly 40 degree;

⑶, the cooling fluid of producing at step ⑵ add saccharomyces cerevisiae 10-40 part, acetobacter xylinum 5-10 part, the logical filtrated air of 28-33 degree stirs (rotating speed 120r/min) and cultivated 12-48 hour, treat that saccharomycete content surpasses 100,000,000 CFU/ml in the zymotic fluid, flavonoid of ginkgo biloba is not less than 0.2mg/ml, emits bacterium liquid and obtain fermentation filtrate with four layer of 100 purpose filter-cloth filtering under aseptic condition;

⑷, in the resulting fermentation filtrate of step ⑶, add bafillus natto 10-20 part, lactobacillus 5-15 part, Bifidobacterium 10-20 part, the 25-35 degree was cultivated 240-300 hour, opened every 48 hours and stirred 5min(rotating speed 120r/min); Treat that pH is down to 2.9-3.2, can stop fermentation, put tank, can, packed products behind the stirring 30min.

Wherein, the described matrimony vine of step ⑵ is through pulverizing 100 orders or processing through making beating.

Wherein, the described gingko pollen of step ⑵ is crossed the 400-500 mesh sieve through ultramicro grinding broken wall and anti-oxidant treatment.

Wherein, the described compound sugar of step ⑵ is fructose oligosaccharides, soyabean oligosaccharides, lactulo-oligosaccharide, the isomaltose compound sugar, one or more in GOS, mannan-oligosaccharides, gentian oligose, wood sugar compound sugar, the inulin are some prebioticses that can promote bifidobacterium growth.

Wherein, the described tealeaves of step ⑵ is one or more in oolong tea, black tea, the green tea.

Wherein, the described lactobacillus of step ⑷ is at least three kinds of equal proportion Mixed Microbes in lactobacillus bulgaricus, lactobacillus acidophilus, Lactobacillus casei, lactobacillus reuteri, Lactobacillus plantarum, streptococcus thermophilus, the Lactobacillus rhamnosus etc., preferred lactobacillus bulgaricus, lactobacillus acidophilus, Lactobacillus casei, four kinds of equal proportion Mixed Microbes of lactobacillus reuteri.

Wherein, the described Bifidobacterium of step ⑷ is bifidobacterium adolescentis, bifidobacterium infantis, bifidobacterium bifidum, at least two kinds of equal proportion Mixed Microbes in the bifidobacterium longum, preferred bifidobacterium adolescentis, two kinds of equal proportion Mixed Microbes of bifidobacterium infantis.

Saccharomyces cerevisiae in step ⑶, ⑷, lactobacillus, acetobacter xylinum, bafillus natto, Bifidobacterium can adopt prior art to cultivate, and the invention provides following methods:

The preparation of saccharomyces cerevisiae liquid spawn

Take out the culture presevation pipe, draw flat board with the PDA solid medium and recover, 30 degree were cultivated 48 hours.In 150 milliliters of PDA culture mediums of the single colony inoculation of picking, 30 degree concussions were cultivated 24 hours in incubator under flat board.Seed adopts 5% inoculum concentration, is seeded to (liquid amount is 2L) in the large triangular flask of 5L, and 30 degree concussions were cultivated 20-28 hour, detected its bacterial concentration, and bacterial content surpasses 500,000,000/milliliter, namely can be used as yeast liquid body bacterial classification inoculation.Wherein said PDA culture medium: potato 200g, sucrose 20g, water 1000mL adds agar 2% in the solid medium.Wherein said saccharomycete seed culture medium: glucose 10 g/L, yeast extract 3 g/L, peptone 5 g/L, ammonium sulfate 5 g/L, magnesium sulfate 0.5 g/L.The condition of each medium sterilization is: 0.10-0.15MPa, sterilized 30 minutes for 121 ℃.

The preparation of lactobacillus liquid spawn

Take out the culture presevation pipe, draw flat board with the MRS solid medium and recover, 37 degree anaerobism were cultivated 48 hours.In 250 milliliters of MRS culture mediums of the single colony inoculation of picking, 37 degree anaerobism were cultivated 24 hours in incubator under flat board.Seed adopts 5% inoculum concentration, is seeded to (liquid amount is 9L) in the large triangular flask of 10L, and 37 degree anaerobism were cultivated 20-28 hour, detected its bacterial concentration, and bacterial content surpasses 10,000,000,000/milliliter, namely can be used as the lactobacillus liquid-spawn inoculation.Wherein said MRS culture medium: peptone 10g/L, yeast extract 5 g/L, beef extract 10 g/L, glucose 20 g/L, sodium acetate 5 g/L, dibasic ammonium citrate 2 g/L, Tween-80 1 ml/L, magnesium sulfate 0.6 g/L, manganese sulfate 0.05 g/L, dipotassium hydrogen phosphate 2 g/L, agar 20 g/L, calcium carbonate 20 g/L add agar 2% in the solid medium.Wherein said lactic acid bacteria seed culture medium: glucose 5%, peptone 1.5%, beef extract 0.75%, sodium chloride 0.1%, manganese sulfate 0.001%, magnesium sulfate 0.02%, sodium acetate 0.05%, calcium carbonate 1%, pH6.0.The condition of each medium sterilization is: 0.10-0.15MPa, sterilized 30 minutes for 121 ℃.

The preparation of acetobacter xylinum bacterial classification

Take out the culture presevation pipe, draw flat board with the acetobacter xylinum solid medium and recover, 30 degree were cultivated 48 hours.In the single colony inoculation to 50 of the picking milliliter acetobacter xylinum culture medium, 30 degree concussions were cultivated 24 hours in incubator under flat board.Seed adopts 5% inoculum concentration, is seeded to (liquid amount is 2L) in the large triangular flask of 5L, and 30 degree 150r/min concussions were cultivated 20-28 hour, detected its bacterial concentration, and bacterial content surpasses 1,000,000,000/milliliter, namely can be used as the acetobacter xylinum liquid-spawn inoculation.Wherein said acetobacter xylinum solid medium: glucose 50.0, peptone 10.0, citric acid 1.5, sodium hydrogen phosphate 1.0, potassium dihydrogen phosphate 3.0, magnesium sulfate 0.3, agar 18.0, deionized water 1L, pH6.8 sterilized 20 minutes for 121 ℃.The acetobacter xylinum liquid seed culture medium: glucose 20.0, peptone 4.0, citric acid 2.0, sodium dihydrogen phosphate 2.7, magnesium sulfate 0.25, deionized water 1L, pH6.8 sterilized 20 minutes for 12l ℃.

The preparation of bafillus natto liquid spawn

Take out the culture presevation pipe, draw flat board with the LB solid medium and recover, 37 degree were cultivated 48 hours.In 50 milliliters of LB culture mediums of the single colony inoculation of picking, 37 degree concussions were cultivated 24 hours in incubator under flat board.Seed adopts 5% inoculum concentration, is seeded to (liquid amount is 2L) in the large triangular flask of 5L, and 37 degree concussions were cultivated 20-28 hour, detected its bacterial concentration, and gemma content surpasses 6,000,000,000/milliliter, namely can be used as the bafillus natto liquid-spawn inoculation.Wherein said LB culture medium: peptone 5g, beef extract 3g, sodium chloride 5g, water 1000mL, pH7.2 adds agar 2% in the solid medium.Wherein said bafillus natto liquid spawn culture medium: glucose 10g/L, corn flour 8 g/L, bean cake powder 25 g/L, magnesium sulfate 0.5 g/L, manganese sulfate 0.5 g/L, sodium dihydrogen phosphate 0.5 g/L, sodium hydrogen phosphate 2.3 g/L, pH7.2.The condition of each medium sterilization is: 0.10-0.15MPa, sterilized 30 minutes for 121 ℃.

The preparation of bifidobacterium species

Take out the culture presevation pipe, draw flat board with the Bifidobacterium solid medium and recover, 37 degree anaerobism were cultivated 72 hours.In 50 milliliters of Medium of Bifidobacteriums of the single colony inoculation of picking, 37 degree anaerobism were cultivated 48 hours in incubator under flat board.Seed adopts 5% inoculum concentration, is seeded to (liquid amount is 9.5L) in the large triangular flask of 10L, and 37 degree anaerobism were cultivated 20-28 hour, detected its bacterial concentration, and bacterial content surpasses 1,000,000,000/milliliter, namely can be used as the Bifidobacterium liquid-spawn inoculation.Wherein said Medium of Bifidobacterium: peptone 5.0g/L, yeast extract 5 g/L, beef extract 5.0 g/L, tryptone 10.0g/L, glucose 10.0 g/L, sodium acetate 5.0 g/L, dibasic ammonium citrate 2.0 g/L, Tween-80 1.0 ml/L, magnesium sulfate 0.1 g/L, zinc sulfate 0.25 g/L, dipotassium hydrogen phosphate 2 g/L add agar 2% in the solid medium.The condition of medium sterilization is: 0.10-0.15MPa, sterilized 30 minutes for 121 ℃.

Health promoting liquid raw material of the present invention contains ginkgo leaf in forming, and the chemical composition of ginkgo leaf comprises flavonoids, terpene lactones, polyisoamylene alcohols, organic acid etc.Wherein GINKGO BILOBA EXTRACT and terpene lactones are the main compositions of ginkgo leaf, have anti-oxidant, improve cardiovascular and cerebrovascular circulation, antitumor, reduce cholesterol, liver protecting, improve the effects such as memory, preventing thrombosis, so ginkgo leaf has very high edible medicinal and is worth.

Ginkgo leaf contains antagonism platelet activating factor (PAF).Studies show that ginkolide B is the strong antagonist of platelet activating factor, can suppress well the formation of platelet aggregation and anti-tampon.PAF is efficient pro-inflammatory mediator, can produce, secrete by various kinds of cell such as inflammatory cell, vascular endothelial cell and blood platelets, be the derivant of the present the strongest platelet aggregation of finding, closely related with the genesis of the various diseases such as asthma, shock, ischemic, allergy, graft-rejection.Ginkgo biloba p.e has the blocking effect of high selectivity to paf receptor.Zoopery proves that ginkgo biloba p.e has the reduction viscosity of blood, delays the effect of blood clotting and inhibition platelet aggregation.

Extract in the ginkgo leaf has effect for reducing blood fat.Ginkgo biloba p.e can effectively reduce blood T-CHOL, triglycerides, the effect of increasing high density lipoprotein, high fat of blood and atherosclerotic and cardiovascular and cerebrovascular disease are closely related, and HDL has study of anti-atherogenic effect, can directly stop the formation of thrombus.Other has report, and ginkgo biloba p.e can also anti peroxidation of lipid, improves Hemorheology, the formation that prevention of arterial is atherosis.

Active material in the ginkgo leaf has anti-oxidant, anti-aging effects.Flavonoids in the ginkgo leaf and ginkgolide compound have good scavenging action to the noxious material (oxygen radical) that cardiovascular cell produces, oxygen radical comprises superoxide anion, hydroxy radical, NO free radical, hydrogen peroxide and singlet oxygen, can strengthen the effect of activities of antioxidant enzymes and improve microcirculation etc., also have anti peroxidation of lipid and antidotal effect.Wu Shuliang etc. are with impact and the anti-aging effects of quantitative stereoscopy method research Ginkgo biloba Leaves on Mice hippocampal neurons ultrastructure, observe two groups of mouse in the variation of the morphological parameters such as different times hippocampal neuron cell space, karyon, kernel, result's methods analyst of Successive Regression, the result shows: the ginkgo leaf group is to along with the mouse increase in age, and the result that nucleus volume reduces, neurone loss increases this phenomenon is not obvious.Illustrate that ginkgo biloba p.e can affect the ultra microstructure of hippocampus neurons in mice, has antioxidation.

Ginkgo biloba p.e has antitumor, antitumaous effect.Malignant tumour is one of four large killers of harm humans health, and its incidence of disease is rising year by year, and it is also not very desirable that alone Western medicine is treated its curative effect of tumour, and therefore, developing anti-tumor medicaments becomes inevitable trend from traditional Chinese medicine.Ginkgo biloba p.e can improve body immunity and once strong bone-marrow-derived lymphocyte antibody generation, strengthens the phagocytic function of macrophage.Under the finite concentration condition, ginkgo biloba p.e can improve the CIK cell to the lethality of tumour cell, and K562 and SGC7901 are easier in the CIK cell killing after ginkgo biloba p.e is processed.This force of Japan pine is separated from ginkgo leaf and is obtained heptadecene salicylic acid and bilobetin, and the two all has good inhibition activity to cancer cell, and particularly bilobetin has surpassed RA to the inhibition of the carcinogenic startup factor.

Active material in the ginkgo leaf has the learning and memory function of improvement.Ginkgo biloba p.e can make the patient reaction realize quickening, memory improvement.Chen Changxun etc. are by the mouse experiment with NaN02 and hyoscine infringement memory, the result shows that ginkgo biloba p.e can make the stop of mouse obviously prolong incubation period, normal mouse is also had the effect that promotes learning and memory, and its mechanism of action may be relevant with the cholinergic nerve that affects maincenter; Can also prolong the time-to-live of NaN02 poisoning mouse, this oxygen lack resistant function and its increase cerebral blood flow (CBF) and when improving anoxic brain energy metabolism may have certain relation.Height waits eastwards by animal model and has confirmed that ginkgolides can recover cholinergic damage memory function, also can prevent the reduction of choline acetyl transfers enzyme activity, strengthens the ability of learning and memory that is caused by basal ganglia lesion.Zhou Lanlan etc. take the experiment of ginkgo biloba p.e by mouse, the result shows that its active ingredient can obviously strengthen the memory function of mouse, also can improve the memory disorders that cause because of cerebral ischemia, this is with relevant to the inhibitory action of superoxide dismutase in the brain tissue and peroxidase activity.

Lactone in the ginkgo leaf has the effect of protection liver.There is the experimental study example to show; ginkolide B has the hepatic injury effect due to the protection endotoxin; can obviously improve the ATP content of hepatic tissue; Flavonoid substances can significantly suppress the level of its end product of lipid hyperoxygen MDA (MDA); and be the doses dependence, thereby the hepatic injury when protecting the rat acute endotoxemia.

Ginkgo biloba p.e has spasmolysis and anti-allergic effects.Can the relax effect of guinea pig in vitro bronchial smooth muscle of ginkgo biloba p.e, and can antihistaminicum and acetylcholine due to bronchoconstriction and by the Experimental Asthma In Guinea-pigs due to the histamine, namely have cough suppressing effect.Its Flavonoid substances bronchus that also can relax, this effect can be by the inderal antagonisms, may be relevant with adrenoreceptor.PAF is one of medium of the diseases such as shock, asthma, anaphylactia, dermatitis and rheumatism, and ginkgolides can be treated the disease relevant with PAF.

Ginkgo biloba p.e has the effect that improves cardiovascular and cerebrovascular and peripheral circulation.Experimental studies have found that, active ingredient in the ginkgo leaf can be improved the effect of myocardium recovery function and myocardial ischemia, its brass class material has the expansion coronary vasodilator, increases CBF, improves peripheral circulation, activates brain tissue metabolism, prevents the effect of Hypoxia and ischemia and encephaledema, also to because the peripheral circulation that blood vessel aging and blood supply insufficiency cause is bad, dizzy, headache, insomnia, failure of memory etc. have therapeutic action.Thereby can be used for the treatment of the diseases such as coronary heart diseases and angina pectoris, hypertension.

Contain gingko pollen in the raw material of health promoting liquid of the present invention, gingko pollen is not only the source of life of ginkgo, and really deserves to be called " miniature nutrition treasure-house ".According to surveying and determination, the protein content of every hectogram pollen can wherein contain tens seed amino acids, and be free state up to 25～30 grams, very easily is absorbed by the body.This is that other any wholefood is incomparable.Also contain 40% sugar and a certain amount of unrighted acid in the pollen, and abundant B family vitamin and vitamin A, vitamin D, vitamin E, vitamin K etc., wherein support one's family E, vitamin K all by scientist confirm can delaying human body the cell ageing process, the important substance of the effect of promoting longevity is arranged.Pollen also contains ten plurality of inorganic salt and 30 various trace elements and 18 kinds of enzymes such as iron, zinc, calcium, magnesium, potassium, also contains hormone, auxin, antibiotic of nucleic acid and some delaying human body caducity etc.Therefore say that pollen is a kind of Almightiness type nutraceutical.

Gingko pollen is not only a kind of nutraceutical, and good medical function is arranged.Clinical experimental data shows, contains a large amount of flavones in the gingko pollen, and lactone isoreactivity material has certain result for the treatment of to angiocardiopathies such as hypertension, highs fat of blood.

Gingko pollen also is proved to be the reinforcing agent of the distinguished muscle power of a kind of effect and endurance.Also contain a kind of dynamical bioactivator because of it, can improve the metabolism of human tissue organ, strengthen cardiovascular function, delay senility, so gingko pollen is again a kind of fat reducing and long life food.

Contain matrimony vine in the raw material of health promoting liquid of the present invention, FRUCTUS LYCII contains 19 seed amino acid compositions, and wherein 8 kinds is needed by human.FRUCTUS LYCII contains 21 kinds of trace elements, comprises germanium---rarely found anticancer trace mineral in the food.FRUCTUS LYCII is than containing more protein (wherein 13% exist with amino acid whose form) in the whole wheat.FRUCTUS LYCII contains oxidation resistant carotenoid, such as beta carotene (this is than contained abundanter in the carrot), zeaxanthin (having the eyeshield effect).FRUCTUS LYCII is that to contain carotenoid in all foods the abundantest.FRUCTUS LYCII is rich in vitamin C, vitamin B compound, vitamin E.FRUCTUS LYCII contains a kind of medium of anti-inflammatory---cupreol.This material can reduce cholesterol, is used for the treatment of impotence and prostatosis.FRUCTUS LYCII contains the aliphatic acid of needed by human, to keep hormone system, brain and neural normal operation.FRUCTUS LYCII contains a kind of mixture---cyperolone, and it is very beneficial to heart and blood pressure, can alleviate dysmenorrhoea, is used for the treatment of cervical carcinoma.FRUCTUS LYCII contains a kind of natural mixture---physalin, and is all very active to resisting most of leukaemia.Contain betaine in the FRUCTUS LYCII, can keeping tensions down, strengthen memory, promote muscle development, the prevention fatty liver.Betaine provides methyl groups for health, reduces the amount of homocysteine, has reduced a cardiopathic major risk factors.It can also protect DNA.FRUCTUS LYCII contains polysaccharide, and it can strengthen immune system, is a kind of born anti-ageing hormone.FRUCTUS LYCII contains very many antioxidants.Antioxidant can prevent the generation of free radical, strengthens immune system, delays senility.In External Mongolia, China, Japan and Switzerland, there is scientist in experiment wolfberry juice to be used as a kind of anticarcinogen.This material has in FRUCTUS LYCII and folium lycii, can kill a lot of cancer cells.Many experiments and clinical research find that wolfberry juice contains ecosystem germanium, and germanium has antitumaous effect.Germanium can inspire the generation of human body G-interferon, and interferon can be suppressed and kill cancer cell.Germanium can also receive the hydrogen ion of separating from cancer cell.Do not had hydrogen ion, cancer cell just is difficult to survival.The researcher of Japan points out that primary germanium and other drug are used, and is very effective to liver cancer, lung cancer, the cancer of the uterus, cervical carcinoma, carcinoma of testis.In several seminar for the elderly, all people that participate in experiment are once a day, adhere to eating the FRUCTUS LYCII in three weeks, and experiment has produced a lot of useful results.67% patient's changing function has increased by 2 times, and patient's interleukin 2 has increased by 1 times.In addition, all patients' spiritual complexion has all been got well a lot, and patient's appetite of 95% has all improved, and 95% patient has slept, and 35% patient's sexual life has recovered.And experiment shows that FRUCTUS LYCII does not definitely have toxicity.

Raw material among the present invention contains tealeaves, contains 400 Multiple components such as caffeine, tannin, Tea Polyphenols, protein, carbohydrate, free amino acid, chlorophyll, carrotene, aromatic oil, enzyme, provitamin A, Cobastab, vitamin C, vitamin E, citrin and inorganic salts, trace element in the tealeaves.Recent studies is found, is often drunk tea and can produce refreshing effect to the mind.Contain the alkaloid about 5% in the tealeaves, its main component is caffeine, and this caffeine has when making tea in the 80% solvable water inlet, and energy excitor nerve maincenter enhances metabolism after drinking, and strengthens cardiac function; And can promote gastric secretion, and aid digestion, separate greasy; Can also strengthen striate contractile function, thereby can make people's relieving fatigue, raise labour efficiency.

Tealeaves has the effect of replenishing body fluid and clearing away heat pathogen, drinks black tea summer and can quench the thirst and relieve summer heat, and is because the Polyphenols in the tea, carbohydrate, amino acid, pectin etc. and mouth saliva produce chemical reaction, and exciting salivary secretion, causes the oral cavity to feel moist, and produces refrigerant sense; The heat center of simultaneously caffeine control hypothalamus, regulate body temperature, it also stimulates kidney to promote the drainage of heat and dirt, keeps the physiological equilibrium in the body.

Tealeaves has the effect of diuresis detoxifcation, under the caffeine in tealeaves and the aromatic substance synergy, increases the CBF of kidney, improves glomerular filtration rate, the nephrectasia capilary, and suppress renal tubule to the again absorption of water, so facilitate the urine amount to increase.So be conducive to get rid of lactic acid in the body, uric acid (relevant with gout), too much salinity (relevant with hypertension), nuisance etc., and relax the oedema that heart disease or ephritis cause.According to the tea polybase energy Adsorption of Heavy Metals and the alkaloid that experiment showed, in the tealeaves, and the precipitation decomposition, detoxication had.

Tealeaves has the effect of strong bone.Japan-US state doctors'associations delivered the male sex 497 people, women 540 people were investigated more than 10 years Mays 13 in 2002, and people's bone of pointing out to drink black tea is strong, and the Polyphenols in the black tea (also having in the green tea) has the vigor that suppresses to destroy the osteocyte material.In order to prevent and treat the common osteoporosis of women, every day is taken a cuvette black tea in suggestion, adheres to the several years successful.

The effect that tealeaves has is anti-oxidant, delay senility.In in the past 5 years, U.S. government has subsidized 150 multinomial researchs about green tea and black tea and chemical composition thereof, and result of study shows, the antioxidant in green tea and the black tea is the propagation path of chemical substance in the destruction of cancer cells thoroughly.The Mittelman doctor says in the bass Israel deaconess medical centre blood vessel epidemiology director China ink of Boston: " effect of black tea and green tea is roughly suitable, but the antioxidant of black tea than the green tea complexity many, especially useful especially to heart ".The USA Magazine report, the anti-ageing effect of black tea is better than garlic, broccoli and carrot etc.

Tealeaves has anticancer, vasodilatory effect.The catechin that contains in the tealeaves and glycosides displayed have the effect that increases capilary elasticity, reduces blood fat and dissolved fat, thereby can prevent in the Hemostatic Oral Liquid or the gathering of cholesterol and neutral fat in the liver, to preventing vascular sclerosis certain effect are arranged.United States Medicine circle has a research relevant with black tea recently.Research finds that the cardiac drinks 4 cups of black tea every day, and the vasodilation degree can be increased to 10% from 6%.Ordinary person is behind irriate, and then diastolic dimension can increase by 13%.

Contain abundant active saccharomyces cerevisiae in the health promoting liquid among the present invention, saccharomyces cerevisiae is rich in the Cobastab group, can effectively improve archenteric flora balance in the human body, strengthens immunity of organisms, abundant nutriment is provided, thereby reaches the control disease of digestive tract and improve the multiple actions such as immunity.

The human gastrointestinal tract endoparasitism a large amount of microorganisms, these microorganisms can keep normal growth metabolism under suitable nutrition substrate, this will be conducive to safeguard the metabolic balance between each fungus strain, and provide a good micro-ecological environment for human body pipe intestinal digesting absorption function, can be fully absorbed and utilize in intestines and stomach so that enter the various nutrients of human body, saccharomycete is facultative anaerobe, can be in human body growth and breeding, the oxygen that can consume in the enteron aisle forms anaerobic environment, and auxiliary lactobacillus metabolism produces the organic acids such as lactic acid, be conducive to lactic acid bacteria, Bifidobacterium is waited the growth of beneficial bacterium, suppresses Escherichia coli, the growth of the harmful bacterias such as salmonella, thereby improve gastrointestinal tract environment and flora structure, promote stomach and intestine to the digestion of nutriment, absorb and utilization.Contain superoxide dismutase (SOD), glutathione in the saccharomycete, and they all are important antioxidant and free radical quenchants.Superoxide dismutase (SOD) in the saccharomycete can resist and block the infringement that cell is caused because of oxygen radical, and in time repairs damaged cell.Glutathione is higher at the yeast cells intensive amount, can eliminate free radical, can play strong protective effect.Glutathione also has the integration detoxication, can combine with toxic compounds, heavy metal ion or the carcinogen etc. in the body, and promotes it to excrete, in playing and detoxication.Glutathione can stop oxygenated haemoglobin, is conducive to the performance of enzymatic activity, and makes again activity recovery of enzyme.Metabolism of yeasts can produce plurality of enzymes and multiple metabolite, and the polymer substance in the degraded Chinese herbal medicine can reduce the chymeviscosity in the enteron aisle, promotes stomach and intestine to digestion, absorption and the utilization of nutriment.Yeast cells is rich in the multiple nutrients material that growth of animals or poultry needs, and protein content reaches 45%～60%, can compare favourably with soybean protein; Amino acid forms rationally, 8 seed amino acid content of needed by human are all very high, be rich in B family vitamin such as nicotinic acid, choline, riboflavin, pantothenic acid, folic acid etc., human body can reach more than 60% to its absorptivity, it is a kind of desirable VB2 supplementary source, be human body and lactic acid bacteria, Bifidobacterium provides multiple nutritional components.

Contain lactobacillus and the Bifidobacterium of a large amount of activity in the health promoting liquid among the present invention, lactobacillus and Bifidobacterium can promote the absorption of the nutriments such as protein, monose and calcium, magnesium, produce a large amount of benefit materials such as vitamin B complex; Make the formation of gut flora that useful variation occur, improve the human gastrointestinal tract function, recover colony balance in the human body intestinal canal, form the antibacterial biological barrier, safeguard health; Suppress the breeding of spoilage organisms, clear up the toxin that spoilage organisms produces, remove enteron aisle rubbish; Suppress cholesterol absorption, reducing blood lipid, hypotensive activity; Also has antitumor, pre-anti-cancer effect; Can improve the SOD enzyme activity, eliminate human free radical, anti-ageing, the effect of promoting longevity of tool; Effectively prevention female genitourinary system bacterium infects; Control toxins in human body level, the protection liver also strengthens detoxifcation, the functions of expelling toxin of liver.

Lactobacillus and Bifidobacterium have absorbefacient effect.Lactobacillus and Bifidobacterium can produce lactic acid and acetic acid after fermenting in the human body intestines, can improve the utilization rate of calcium, phosphorus, iron, promote the absorption of iron and vitamin D.The bifidobacterium fermentation lactose produces galactolipin, is to consist of cerebronic composition in the cerebral nervous system, with the ramp of baby due hindbrain substantial connection is arranged.Lactobacillus and Bifidobacterium can produce the nutriment of the needed by human such as vitamin B1, B2, B6, B12 and alanine, valine, aspartic acid and threonine, have the important trophism that can not be ignored for human body.

Lactobacillus and Bifidobacterium have antidotal effect.Little Ecological Investigation American-European and Japan shows, the bifidobacteria in the long lived elder ight soil with in, quite young.China scientist also got identical result to the investigation of Bama Area In Guangxi long lived elder.The antidotal reason of Bifidobacterium is because Bifidobacterium can suppress the spoilage organisms growth, reduces the generation of the harmful substances such as ammonia, hydrogen sulfide, indoles and scatol in its metabolite.

Lactobacillus and Bifidobacterium can be treated chronic diarrhea.By clinical observation studies show that to Chronic Diarrhea Patients with lactobacillus and Bifidobacterium, after two weeks of taking medicine, patient's times of defecation, shape anomaly, clinical symptom disappearance is 90.3% to total effective rate, recurrence rate is low.Many domestic hospitals are with lactobacillus and the bifidobacterium preparations choice drug as the treatment chronic diarrhea.Antibiotic-associated Colitis is actually antibiotic use, make originally pass by on one's way bacterium or foreign nationality bacterium (such as enterobacteria) become dominant population, after their a large amount of propagation or the relevant toxin of secretion and the intestinal epithelial cell receptors bind CAMP enzymatic activity is raise, large water gaging salt electrolyte is lost, and causes symptom of diarrhea.Propagation lactobacillus and Bifidobacterium have been fostered the ancestral home bacterium in the enteron aisle, and body field planting drag is raise, and are conducive to the field planting of antagonism pathogenic bacteria and conditioned pathogen.Lactobacillus and Bifidobacterium can be treated the pseudomembranous enteritis of using antibiotic to cause because of a large amount of.Someone adopts lactobacillus and bifidobacterium preparations treatment pseudomembranous enteritis 380 examples, clinical total cure rate no significant difference, but clinical side effects and recurrence rate all obviously reduce.

Bifidobacterium can be treated constipation.Constipation refers to that defecation frequency reduces or the ight soil drying is difficult to resolve (general more than two days without defecation), and it can be divided into organic constipation and functional consitipation two large classes haply according to the cause of disease.Lactobacillus and Bifidobacterium are mainly used in this class symptom of functional consitipation.Cause that functional consitipation is in general closely related with the imbalance of enteron aisle bacterium, mostly reciprocal causation.Becoming it is that the spoilage organisms such as enteron aisle foreign nationality bacterium (or the bacterium that passes by on one's way) increases, and it produces the materials such as corresponding toxic metabolite product such as amine, phenol, indoles.By adjusting normal intestinal flora, recover the normal intestinal flora balance, spoilage organisms quantity is greatly reduced, and its toxic metabolite product absorbs minimizing, thereby the constipation symptom is alleviated.Especially replenish the ancestral home bacterium such as Bifidobacterium, it produces acetic acid and lactic acid pH value is 2.8 ~ 3.1, make enteron aisle be acid, its result can control by harmful microbial abnormal fermentation, and the stimulation enterocinesia, thereby reduce the taken in excess of moisture and the relief of constipation symptom can also be brought back to life body's immunity, be conducive to adjust endocrine-immunologic function and recover, thus the symptoms such as recovery intestines peristalsis function relief of constipation.

Lactobacillus and Bifidobacterium can prevent curing oncoma and cancer.Aflatoxins is the Mycophyta toxin of frequent contaminated food products, but its induced hepatocellular carcinoma.Experimental result confirms Bifidobacterium Binding in vivo aflatoxins ability.Lactobacillus can be combined with cancer derivants such as inferior ammonium nitrate or nitrosoguanidines with Bifidobacterium in addition, covers the active gene of mutagens, or makes the degraded of mutagens active gene, causes it and promotes active.Experimental results show that Bifidobacterium and bacon or fried food mutagen have high adsorption, thereby the protection body cell is avoided these carcinogen infringements.Lactobacillus and Bifidobacterium can suppress the many spoilage organisms growths of enteron aisle, thereby reduce some carcinogens generations by adjusting normal intestinal flora, thereby greatly reduce the incidence of alimentary tract cancer.The recent domestic scholar reports that lactobacillus and Bifidobacterium have the activate the phagocytic capacity that activates macrophage in body or LAK cell, and produces the directly kill tumor cell such as a certain amount of cell factor such as TNF-a INF-V.Suppress intratumoral vasculature and form, destroy the tumor tissues capilary, finally cause hemorrhage, downright bad.The physiological bacteriums such as Bifidobacterium can be by apoptosis of tumor cells the related gene of expression, the apoptosis of induced tumor cell and reach the effect that suppresses tumor growth.Aging and heterogeneousization of induced tumor cell.In order to impel in the body LAK and day phagocytal identification and catch and kill.Reach the purpose of removing tumour cell.Can increase body to the tolerance of the radioactive ray of radiotherapy, improve the gastrointestinal side effects such as the feeling sick of chemicotherapy patient, vomiting.

Lactobacillus and Bifidobacterium have the effect of liver protecting.The harmful bacteria of human body intestinal canal produces and discharges toxin and enters in the blood, can produce very major injury for liver.Lactobacillus and bifidobacterium preparations can suppress toxigenic harmful bacteria quantity, thereby the liver patient is played good therapeutic action.8 domestic large hospitals adopt lactobacillus and bifidobacterium preparations that 365 routine chronic hepatitis patients are advanced the treatment of 8 weeks, and discovery patient liver function is obviously improved.Bifidobacterium can also be used for the treatment of hepatic coma, and can suppress hepatitis B, promotes large and small three sun to turn out cloudy.

Lactobacillus and Bifidobacterium can prevention and cure of cardiovascular diseases.Cholesterol level can cause artery sclerosis and hypertensive generation in the blood of human body, the beneficial bacterium such as lactobacillus and Bifidobacterium can affect the metabolism of cholesterol, be translated into the non-absorbent steroids of human body, reduce the concentration of Blood Cholesterol, thereby hypertension and artery sclerosis are had certain preventive and therapeutic effect.

Lactobacillus and Bifidobacterium can be improved the anti-lactose of dairy products, improve digestibility, strengthen the non-specific and specific immune response of body, can control the effect of endotoxemia, can improve the host to the tolerance of radioactive ray.

Contain a large amount of acetobacter xylinums in the health promoting liquid of the present invention, acetobacter xylinum is aerophile bacterium, and needing could rapidly a large amount of growth under the condition of aerobic.But the acetic acid bacteria of it and other is different, and under the condition of anoxic, it can utilize glucose to carry out anaerobic fermentation, and can make conversion of glucose is acetic acid and lactic acid, can the promptly mortality because of anoxic.And acetobacter xylinum can make rapidly glucose oxidase become gluconic acid, 2-ketone gluconic acid under the condition of aerobic, and Oxidation of Alcohol is acetic acid; Because these characteristics, it except amount reproduction in the situation of nutrient solution top layer oxygen amount foot forms mycoderm, also can form floccule in bacterium liquid in zymotic fluid, keep a considerable amount of thalline.Under the condition of aerobic, acetobacter xylinum has very strong oxidability to glucose, and concrete ways is: glucose → gluconic acid → glucuronic acid → glucaric acid → glucaric acid Isosorbide-5-Nitrae lactone, product is detoxifcation, anticancer function factor in the middle of it.Glucuronic acid, it is one of topmost detoxifcation material among the human liver.Glucuronic acid can combine with the endogenous noxious material that toxin or the body metabolism of external source produce, become water miscible glucosiduronate, and excrete together, may cause that the toxin various pathologies of health or that pathology has occured in time removed the good result that plays diseases prevention and cure the disease thereby make.The another kind of functional components glucaric acid 1 that exists in the health promoting liquid, 4 lactones can make the destruction of heparin, hyaluronic acid, mucoitin sulfate and glucuronic acid greatly reduce, help health more effectively to discharge toxin, cancer-resisting, and caused other discomfort of releasing arthritis, gout, asthma and linked groups's function reduction.Gluconic acid can be combined with heavy metal and be formed water-soluble compound, helps human body to discharge harmful heavy metal element.

In addition, acetobacter xylinum has very strong cellulosic synthesis capability, and an acetobacter xylinum cell per hour can be linked to be cellulose to 100,000,000 glucose units, and can produce the cellulose of 3-4cm every day.These bacteria celluloses are not are not digested and assimilated for human body fully, have satiety after the food, can reduce appetite and as diet food low in calories.And can increase faecal volume, the dilution poisonous substance promotes enterocinesia and defecation, anti-treating constipation.Oneself has many studies confirm that now, and the more food (they are the prebioticses that grow easily probio) of fiber content helps to prevent type ii diabetes.The German Research personnel find that in new research full cereal preparation and a lot of contained non-soluble fiber of vegetables can improve human body to the situation of utilizing of insulin, thereby help to prevent type ii diabetes.Insulin can be regulated blood sugar, and it is the omen that human body is suffered from type ii diabetes that insulin sensitivity descends.Some researchs in the past are own through showing, the diet that non-soluble fiber content is high helps to reduce the risk of suffering from diabetes.For finding out association wherein, the women that the German human nutrient research researcher of institute is 17 overweights has designed different diet programs, to explore the function of non-soluble fiber.The researcher allows the women that participates in the experiment eat for three days on end first the bread that is rich in non-soluble fiber, eats the few bread of fiber content in after this 3 days again.Comparative analysis shows that the diet that is rich in non-soluble fiber has improved these women's insulin sensitivity.They are published in achievement in research on " diabetes care ".

Contain a large amount of bafillus nattos in the health promoting liquid of the present invention; bafillus natto is to have beneficial bacterium acidproof, heat-resistant quality; four hours survival rates are 100% under hydrochloric acid in gastric juice; having simultaneously powerful pathogen and suppress ability, is in the middle of the various beneficial bacterium, to environment tolerance one of the bacterial classification of small intestine that preferably can go directly; can change human body intestinal canal flora ecology after oral; help digest function normalization, so that defecation is smooth and easy, keep the body physiological environmental protection.Energy regulating intestinal canal flora, the enhancing animal cell immunity is put should.And can generate multiple protein enzyme, carbohydrase, lipase, amylase, some complicated compound in the degrading plant raw material, thereby the digestibility of raising raw material.

The Nattokinase that bafillus natto produces is the plasmase that directly decomposes thrombus.Have powerful thrombolytic effect, also be eager to excel than the ability of urokinase, every gram natto thrombolytic effect is equivalent to urinate sharp 1600FU, non-inactivation in stomach and intestine.Nattokinase is compared with urokinase the long action time of thrombus 3 minutes～5 minute action time, and the Nattokinase effect reaches 8 hours, and safely, have no side effect.Often eat bafillus natto and also the thrombolysis in the capillary can be fallen, effectively improve microcirculation disorder.

Saccharomycete, acetobacter xylinum, lactobacillus, Bifidobacterium, bafillus natto that health promoting liquid fermentation of the present invention is used are through careful screening, are the symbiosis of mutual reciprocity and mutual benefit in Chinese herbal medicine fermented liquid.In the fermentation incipient stage, because acetobacter xylinum can not directly utilize sucrose or utilize the speed of sucrose very slow, by saccharomycete sucrose is degraded to glucose and fructose, the one-step fermentation of going forward side by side produces ethanol, acetobacter xylinum begins the raised growth breeding after glucose, fructose and ethanol have then been arranged in nutrient solution, glucose and fructose oxidation are produced the metabolites such as gluconic acid, acetic acid, and the oxidation of ethanol that yeast produces is generated acetic acid.Play an important role in the saccharomycetic breeding of the preliminary stage of whole fermentation.Have data to show, the ethanol that saccharomycete produces can stimulate the growth of acetobacter xylinum, produces more cellulose membrane and acetic acid, and the acetic acid that acetobacter xylinum produces can stimulate saccharomycete to produce ethanol, and the existence of acetic acid, ethanol can be protected acetobacter xylinum and saccharomycete.

At this health promoting liquid fermentation initial stage, saccharomycete can amount reproduction under the condition of aerobic and is produced many metabolites that are beneficial to man, as, vitamin B1, vitamin B2, citric acid, the organic acids such as butanedioic acid, protein and amino acid, fat, nucleic acid material, multiple hormone etc.When under anaerobic conditions, saccharomycete can become alcohol and carbon dioxide to carbohydrate fermentations such as glucose, meanwhile lentamente growth.Saccharomycete and bafillus natto can produce the polymer substance that various enzymes (such as cellulase, protease, carbohydrase, amylase) decompose Chinese herbal medicine, and glycometabolism is produced various materials, and the nutriment of growth is provided for pyroligneous acid bacterium, lactic acid bacteria, Bifidobacterium.

Chinese herbal medicine leaches liquid behind multiple probiotics fermention, and color all improves significantly.The blue or green gas of original ginkgo leaf, flavour of a drug disappear, and bitter taste significantly descends, and has obvious flowers and fruits fragrant and sweet, and flavour is pure and mild tasty and refreshing, by the antioxidation activity of chemiluminescence determination health promoting liquid, find that its biologically active greatly improves after fermentation.To the analysis showed that the Ginkgolides material in the health promoting liquid forms, the content of the bitter principle flavonols glycoside material in the zymotic fluid obviously descends, be reduced to half of contrast such as rutin, and the stronger flavonols content of resistance to oxidation increases, and has increased nearly one times such as quercetin content.Tentatively verify, under the effect of the secreted beta-glycosidase of probio.The glycosyl of flavonols glycoside is dissociated in the health promoting liquid, is degraded to flavonols.The structural change of flavone compound, the increase of phenolic hydroxyl group total amount in the zymotic fluid is the main cause of the resistance to oxidation enhancing of fermented health-care liquor, in addition, because the flavonols glycoside is bitter substance main in the ginkgo leaf, its degraded also is the major reason that green tea promotes after fermentation.Along with the prolongation of fermentation time, the content of general flavone is the trend of rising in the health promoting liquid, all the raising of health promoting liquid resistance to oxidation is had contribution.

Behind the probiotics fermention Chinese herbal medicine in the health promoting liquid of the present invention, show the content of trace element zinc, copper, selenium, germanium, iron, manganese, nickel and cobalt to the human body beneficial through testing result than the height that leaches without the Chinese herbal medicine that ferments in the water, and the content of harmful ginkgoic acid, lead and chromium seldom.

The active material that contains a large amount of Chinese herbal medicines in the health promoting liquid of the present invention, such as GINKGO BILOBA EXTRACT, ginkgolides, polysaccharides from ginkgo biloba, caffeine, tannin, Tea Polyphenols, protein, carbohydrate, free amino acid, chlorophyll, carrotene, aromatic oil, enzyme, carotenoid, cupreol, betaine, vitamin A, Cobastab, vitamin C, vitamin E, citrin and inorganic salts, primary germanium, trace element waits hundreds of kind extract, these Chinese herbal medicine active matters can not only play the effect of preventing and treating diseases, can also promote the acetobacter xylinum in the health promoting liquid, saccharomycete, lactobacillus, Bifidobacterium, the symbiotic fermentation effect of Bacillus natto, and produce a large amount of intermediate products, such as glucuronic acid, gluconic acid, acetic acid, alcohol, lactic acid, amino acid, protein, folic acid, Nattokinase, superoxide dismutase (SOD), glutathione, lactobacillin, lactase, glucaric acid 1,4 lactones, bacteria cellulose, bifid rhzomorph, lichenic acid, Vc, with multiple B family vitamin etc.Health promoting liquid of the present invention is by distinctive fermentation mode, and with various viable bacterias, the Chinese herbal medicine active material reaches various metabolites and organically combines, and has the following advantages:

⑴, safeguard the normal intestinal flora balance, suppress the growth of pathogen, anti-treating constipation, diarrhoea, and gastrointestinal disorders etc.;

⑵, antitumor, anti-curing cancers; Mainly be because the gut flora situation is improved, and the Chinese herbal medicine active material has suppressed the carcinogen generation, the content of indole and phenol in the reduction intestines; Activated immunologic function, inhibition cancer cell propagation;

⑶, be rich in vitamin, amino acid and raising body to the absorption of healthy trace elements with household;

⑷, improve cardiovascular and cerebrovascular circulation, softening blood vessel reduces the Blood Cholesterol level, prevents and treats hypertension, high fat of blood, prevention coronary heart disease;

⑸, enhancing human immunologic function, Antioxidants is high, eliminates human free radical, and is anti-ageing, promotes longevity;

⑹, produce refreshing effect to the mind, improve memory, strengthen the non-specific and specific immune response of body;

⑺, control volume level of endotoxin, liver protecting strengthens liver detoxification, toxin expelling effect;

⑻, improve human body to the tolerance of radioactive ray.

Composite probiotics ferment Chinese herbal medicine active health liquid of the present invention is compounded with the disease-treatment and health-care function of multiple single product, namely contain anticancer, as to strengthen the functions such as memory, control " three height ", raising immunity medicinal herb components, has again the beneficial flora that can regulate the stomach and intestine inner equilibrium, integrate health care and treat, meet the medical science viewpoint that current people's prevention, health care, treatment combine with rehabilitation, market prospects will be more extensive.

Security and preventing and treating diseases effect below in conjunction with test explanation composite probiotics ferment Chinese herbal medicine active health liquid of the present invention (abbreviation health promoting liquid).

One, the safety testing effect of health promoting liquid of the present invention

Compound probiotic Chinese herbal medicine active health liquid of the present invention in Shaoyang institute through rat acute toxicity test, conclusion The results shows that health promoting liquid is to rat (by feed health promoting liquid of the present invention 14 days of 0.6ml/10g body weight) effect: rat all survives, activity freely, hair smoothing, diet is normal, respiratory tract, eye and oral cavity etc. are located without outside the secretion, do not find any poisoning symptom, and body weight all has increase.With blank group control group, relatively, the rat body weight of this health promoting liquid of feeding obviously increases (P＜0.001).14 day observation period finished, and the rat dislocation put to death dissect, and visually observed the internal organs such as the heart, liver, spleen, lung, kidney, brain, intestines, small intestine and was showed no obvious abnormalities performance.In addition, rat chest gland coefficient and Spleen coefficient result show, compare with the blank group, and health promoting liquid rats in test groups Spleen coefficient obviously increases (P＜0.01), points out this health promoting liquid to have immunological enhancement, true border non-toxic type material, and degree of safety is large.

Compound probiotic Chinese herbal medicine active health liquid of the present invention in Guangxi University through acute toxicity test in mice, conclusion The results shows that health promoting liquid is to mouse (by feed health promoting liquid of the present invention 14 days of 0.4ml/10g body weight) effect: mouse all survives, activity freely, hair smoothing, diet is normal, respiratory tract, eye and oral cavity etc. are located without outside the secretion, do not find any poisoning symptom, and body weight all has increase.With blank group control group, relatively, the Mouse Weight of this health promoting liquid of feeding obviously increases (P＜0.001).14 day observation period finished, and the mouse dislocation put to death dissect, and visually observed the internal organs such as the heart, liver, spleen, lung, kidney, brain, intestines, small intestine and was showed no obvious abnormalities performance.Point out the true border of this health promoting liquid non-toxic type material, degree of safety is large.

Two, this health promoting liquid is in the effect of preventing and treating on hypertension and the coronary heart disease

Hypertensive diagnostic criteria: in the situation of not taking medicine, measuring condition meets the blood pressure diagnostic criteria, and adult (over 18 years old) systolic pressure 〉=140mmHg or diastolic pressure 〉=90mmHg are hypertension;

Blood pressure level is classified as follows:

Ideal bp: systolic pressure＜120, diastolic pressure＜80;

Normal arterial pressure: systolic pressure＜130, diastolic pressure＜85;

Normal high value: systolic pressure 130-139, diastolic pressure 85-89;

1 grade of hypertension: systolic pressure 140-159, diastolic pressure 90-99;

2 grades of hypertension: systolic pressure 160-179, diastolic pressure 100-109;

3 grades of hypertension: systolic pressure 〉=180, diastolic pressure 〉=110;

ISH: systolic pressure 〉=140, diastolic pressure＜90;

Subgroup: critical systolic hypertension: systolic pressure 140-149, diastolic pressure＜90;

The dangerous definition of hypertension layering:

1, high dangerous group: 3 grades of hypertension or hypertension 1-2 level companion's target organ damage (such as diabetes, the heart, brain, kidney, angiosis) and relevant clinical disease;

2, high-risk group: hypertension 1-2 level, accompany at least 3 target organ damages, hazards;

3, middle danger group: 1 grade of hypertension, accompany 1-2 target organ damage, hazards, or 2 grades of hypertension are without being no more than 2 target organ damages, hazards;

4, low danger group: 1 grade of hypertension is not mixed with above-mentioned hazards.

To the hyperpietic (men and women half and half) of above-mentioned standard, it is as follows to take health promoting liquid result for the treatment of of the present invention: after the meal oral 50ml once, drink-service after mixing with the warm water of one times of health promoting liquid, three times on the one, 15 days courses for the treatment of are through 1-2 the course for the treatment of.The component curative effect:

Normal high value: 1628 people reach normal arterial pressure 32 people, reach ideal bp 1596 people;

1 grade of hypertension: 940 people reach normal high value 2 people, reach normal arterial pressure 113 people, reach ideal bp 825 people;

2 grades of hypertension: 328 people reach normal high value 28 people, reach normal arterial pressure 84 people, reach ideal bp 216 people;

3 grades of hypertension: 168 people reach 2 grades of hypertension 1 people, reach 1 grade of hypertension 11 people, reach normal high value 19 people, reach normal arterial pressure 68 people, reach ideal bp 69 people;

Low danger group: 1628 people reach normal group 32 people, reach desirable group 1596 people;

Middle danger group: 940 people have reached normal group 115 people.Reach desirable group 825 people;

High-risk group: 328 people reach normal group 112 people, reach desirable group 216 people;

High danger group: 168 people reach high-risk group of 1 people, reach middle danger and organize 4 people, reach low dangerous group 7 people, reach normal group 87 people, reach desirable group 69 people.

Case 1

Grandson, woman, 65 years old, Shaoyang, Hunan Province retired professor of institute, disease time: on November 15th, 2009, the highest 170/100mmHg of hypertension, throughout the year constipation.The treatment history: once used captopril, three smart these Lepings etc., antihypertensive effect is bad, still has discomfort.28 days to 2010 January in 2010, cut off all Western medicine on February 28,, drinks after meal 50ml health promoting liquid of the present invention (eating method: the warm water with one times of health promoting liquid mixes rear drink-service) every day, and it is normal that blood pressure recovers, and the constipation symptom also disappears.

Case 2

Wu, man, 58 years old, the boss of individual enterprise, hypertension, coronary heart disease 4 years.Once used multiple western medicines in treatment, effect is bad.Have a medical check-up: spirit is not good enough, lip, the slight cyanosis of complexion, blood pressure 152/92mmHg.Heart: border of cardiac dullness enlarges two horizontal fingers left, hear sounds blunt and a little less than.Diagnosis: coronary heart disease companion heart failure.2 days to 2011 April in 2011, cut off all Chinese and Western medicines on June 10,, drinks after meal 50ml health promoting liquid of the present invention every day, and it is normal that health is recovered, and it is normal that hear sounds and cardiac size recover.

Case 3

Lee, the man, 50 years old, the Changsha government civilian, disease time: more than 2 years, hypertension 160/100mmHg during treatment, treatment history: once used Compound Reserpine, Danshen Tablets, poor effect.The main suit: head is sick dizzy, insomnia.4 days to 2010 November in 2010, drank after meal 50ml health promoting liquid of the present invention on November 20, every day, and blood pressure is replied normal, and sleep is good.

Three, the effect of this health promoting liquid on anti-treating constipation

It is as follows to take health promoting liquid treatment constipation effect of the present invention: to constipation 219 people, oral 50ml once after the meal, mix rear drink-service, three times on the one, seven days courses for the treatment of with the warm water of one times of health promoting liquid, through 1-2 the course for the treatment of, always effectively can reach 100%, cure rate reaches more than 80%, after the healing, at least drank health promoting liquid one time, and the constipation symptom substantially no longer occurred in per two days.

Case 1

Tight certain, man, 68 years old, Longhui County, the Hunan Province retired cadre of government suffered from the habitual constipation more than 10 years, though through curing, but poor effect, in July, 2011, one after each meal every day health promoting liquid 50ml of the present invention is after three days, constipation improves, constipation transference cure after one week, drink once later every day, constipation do not occur so far again.

Case 2

Zhang, the woman, 38 years old, certain company technique senior executive, cancer of the stomach is with the stomach Partial Resection the year before, nearly constipation half a year, in October, 2011, one after each meal every day health promoting liquid 50ml of the present invention, two days later, constipation improves, constipation transference cure after the week, and drink once later every day, constipation do not occur so far again.

Case 3

Grandson, the woman, 27 years old, the Shaoyang City government civilian had a delicate constitution, puerperal constipation, in February, 2010, one after each meal every day health promoting liquid 50ml of the present invention, after one day, constipation improves, constipation transference cure after one week, drink once later every day, has rosy cheeks, and constipation do not occur so far again.

The specific embodiment

Substantive distinguishing features of the present invention can be embodied from the following examples, but these embodiment only as an illustration, rather than limits the invention.

Embodiment 1

The raw material for preparing this composite probiotics ferment Chinese herbal medicine active health liquid is by weight: 2 parts of gingko pollens, 12 parts of matrimony vines, 8 parts of ginkgo leaves, 4 parts of black teas, 15 parts of bafillus nattos, 20 parts of saccharomyces cerevisiaes, 3 parts of lactobacillus bulgaricus, 3 parts of lactobacillus acidophilus, 3 parts of Lactobacillus caseis, 3 parts of lactobacillus reuteris, 8 parts of acetobacter xylinums, 5 parts of bifidobacterium adolescentises, 10 parts of bifidobacterium infantises, 30 parts of white granulated sugars, 30 parts in brown sugar, 10 parts of defatted soy flours, 15 parts of honey, 2 parts of fructose oligosaccharides, 2 parts of inulin, 2 parts in sodium chloride, 800 parts of deionized waters.

The preparation method of this composite probiotics ferment Chinese herbal medicine active health liquid may further comprise the steps:

⑴ the preliminary treatment of, ginkgo leaf: 8 parts of ginkgo leaf powders are broken to the 20-40 order, and deionized water 60 degree that add 20 times were precooked 5 minutes, dewatered with 8 layers of filtered through gauze;

⑵, in fermentation tank, add through pretreated ginkgo leaf powder, add 800 parts of deionized waters, 100 degree insulations are after 30 minutes, under 100 degree, be incubated 20 minutes again after adding 12 parts of matrimony vines, 4 parts of black teas, 30 parts of white granulated sugars, 30 parts in brown sugar, 15 parts of honey, 10 parts of defatted soy flours, 2 parts of fructose oligosaccharides, 2 parts of inulin, sodium chloride 2-4 part, mixing, then be cooled to 80 degree, add 2 parts of gingko pollens, be incubated 20 minutes, be down to rapidly 40 degree;

⑶, the cooling fluid of producing at step ⑵ add 20 parts of saccharomyces cerevisiaes, 8 parts of acetobacter xylinums, the logical filtrated air of 28-33 degree stirs (rotating speed 120r/min) and cultivated 12-48 hour, treat that saccharomycete content surpasses 100,000,000 CFU/ml in the zymotic fluid, flavonoid of ginkgo biloba is not less than 0.2mg/ml, emits bacterium liquid and obtain fermentation filtrate with four layer of 100 purpose filter-cloth filtering under aseptic condition;

⑷, in the resulting fermentation filtrate of step ⑶, add 15 parts of bafillus nattos, 3 parts of lactobacillus bulgaricus, 3 parts of lactobacillus acidophilus, 3 parts of Lactobacillus caseis, 3 parts of lactobacillus reuteris, 5 parts of bifidobacterium adolescentises, 10 parts of bifidobacterium infantises, the 25-35 degree was cultivated 240-300 hour, opened every 48 hours and stirred 5min(rotating speed 120r/min); Treat that pH is down to 2.9-3.2, can stop fermentation, put tank, sterile filling, packed products behind the stirring 30min.

Embodiment 2

The raw material for preparing this composite probiotics ferment Chinese herbal medicine active health liquid is by weight: 1 part of gingko pollen, 6 parts of matrimony vines, 10 parts of ginkgo leaves, 6 parts of green teas, 15 parts of bafillus nattos, 20 parts of saccharomyces cerevisiaes, 3 parts of lactobacillus bulgaricus, 3 parts of lactobacillus acidophilus, 3 parts of Lactobacillus caseis, 3 parts of lactobacillus reuteris, 8 parts of acetobacter xylinums, 5 parts of bifidobacterium adolescentises, 10 parts of bifidobacterium infantises, 30 parts of white granulated sugars, 30 parts in brown sugar, 10 parts of defatted soy flours, 15 parts of honey, 2 parts of GOSs, 2 parts of inulin, 2 parts in sodium chloride, 800 parts of deionized waters.

⑴ the preliminary treatment of, ginkgo leaf: 10 parts of ginkgo leaf powders are broken to the 20-40 order, and deionized water 60 degree that add 20 times were precooked 5 minutes, dewatered with 8 layers of filtered through gauze;

⑵, in fermentation tank, add through pretreated ginkgo leaf powder, add 800 parts of deionized waters, 100 degree insulations are after 30 minutes, under 100 degree, be incubated 20 minutes again after adding 6 parts of matrimony vines, 6 parts of green teas, 30 parts of white granulated sugars, 30 parts in brown sugar, 15 parts of honey, 10 parts of defatted soy flours, 2 parts of GOSs, 2 parts of inulin, sodium chloride 2-4 part, mixing, then be cooled to 80 degree, add 1 part of gingko pollen, be incubated 20 minutes, be down to rapidly 40 degree;

Embodiment 3

The raw material for preparing this composite probiotics ferment Chinese herbal medicine active health liquid is by weight: 1 part of gingko pollen, 6 parts of matrimony vines, 12 parts of ginkgo leaves, 6 parts of oolongs, 15 parts of bafillus nattos, 20 parts of saccharomyces cerevisiaes, 5 parts of lactobacillus bulgaricus, 5 parts of lactobacillus acidophilus, 5 parts of lactobacillus reuteris, 6 parts of acetobacter xylinums, 5 parts of bifidobacterium adolescentises, 10 parts of bifidobacterium infantises, 20 parts of white granulated sugars, 20 parts in brown sugar, 10 parts of defatted soy flours, 15 parts of honey, 2 parts of GOSs, 2 parts of inulin, 2 parts in sodium chloride, 800 parts of deionized waters.

⑴ the preliminary treatment of, ginkgo leaf: 12 parts of ginkgo leaf powders are broken to the 20-40 order, and deionized water 60 degree that add 20 times were precooked 5 minutes, dewatered with 8 layers of filtered through gauze;

⑵, in fermentation tank, add through pretreated ginkgo leaf powder, add 800 parts of deionized waters, 100 degree insulations are after 30 minutes, under 100 degree, be incubated 20 minutes again after adding 6 parts of matrimony vines, 6 parts of oolongs, 20 parts of white granulated sugars, 20 parts in brown sugar, 15 parts of honey, 10 parts of defatted soy flours, 2 parts of GOSs, 2 parts of inulin, sodium chloride 2-4 part, mixing, then be cooled to 80 degree, add 1 part of gingko pollen, be incubated 20 minutes, be down to rapidly 40 degree;

⑶, the cooling fluid of producing at step ⑵ add 20 parts of saccharomyces cerevisiaes, 6 parts of acetobacter xylinums, the logical filtrated air of 28-33 degree stirs (rotating speed 120r/min) and cultivated 12-48 hour, treat that saccharomycete content surpasses 100,000,000 CFU/ml in the zymotic fluid, flavonoid of ginkgo biloba is not less than 0.2mg/ml, emits bacterium liquid and obtain fermentation filtrate with four layer of 100 purpose filter-cloth filtering under aseptic condition;

⑷, in the resulting fermentation filtrate of step ⑶, add 15 parts of bafillus nattos, 5 parts of lactobacillus bulgaricus, 5 parts of lactobacillus acidophilus, 5 parts of lactobacillus reuteris, 5 parts of bifidobacterium adolescentises, 10 parts of bifidobacterium infantises, the 25-35 degree was cultivated 240-300 hour, opened every 48 hours and stirred 5min(rotating speed 120r/min); Treat that pH is down to 2.9-3.2, can stop fermentation, put tank, sterile filling, packed products behind the stirring 30min.

Claims

1. composite probiotics ferment Chinese herbal medicine active health liquid and preparation method thereof, it is characterized in that the raw material for preparing this health promoting liquid is by weight: 800 parts of gingko pollen 1-3 parts, matrimony vine 4-20 part, ginkgo leaf 5-20 part, tealeaves 2-10 part, bafillus natto 10-20 part, saccharomyces cerevisiae 10-40 part, lactobacillus 5-15 part, acetobacter xylinum 5-10 part, Bifidobacterium 10-20 part, white granulated sugar 20-40 part, brown sugar 10-40 part, defatted soy flour 10-20 part, honey 10-20 part, compound sugar 2-10 part, sodium chloride 2-4 part, deionized water.

2. the preparation method of composite probiotics ferment Chinese herbal medicine active-fermented broth according to claim 1 is characterized in that, comprises the steps:

⑶, the cooling fluid of producing at step ⑵ add saccharomyces cerevisiae 10-40 part, acetobacter xylinum 5-10 part, the logical filtrated air of 28-33 degree stirs (rotating speed 120r/min) and cultivated 12-48 hour, treat that saccharomycete content surpasses 100,000,000 CFU/ml, flavonoid of ginkgo biloba is not less than 0.2mg/ml, emits bacterium liquid and obtain fermentation filtrate with four layer of 100 purpose filter-cloth filtering under aseptic condition;

⑷, in the resulting fermentation filtrate of step ⑶, add bafillus natto 10-20 part, lactobacillus 5-15 part, Bifidobacterium 10-20 part, the 25-35 degree was cultivated 240-300 hour, opened every 48 hours and stirred 5min(rotating speed 120r/min); Treat that pH is down to 2.9-3.2, can stop fermentation, put tank, sterile filling, packed products behind the stirring 30min.

3. the preparation method of composite probiotics ferment Chinese herbal medicine active-fermented broth according to claim 1 is characterized in that, lactobacillus is lactobacillus bulgaricus, lactobacillus acidophilus, Lactobacillus casei, lactobacillus reuteri, Lactobacillus plantarum, streptococcus thermophilus, at least three kinds of equal proportion Mixed Microbes in the Lactobacillus rhamnosus etc., preferred lactobacillus bulgaricus, lactobacillus acidophilus, Lactobacillus casei, lactobacillus reuteri equal proportion Mixed Microbes.

4. the preparation method of composite probiotics ferment Chinese herbal medicine active-fermented broth according to claim 1, it is characterized in that, Bifidobacterium is bifidobacterium adolescentis, bifidobacterium infantis, bifidobacterium bifidum, at least two kinds of equal proportion Mixed Microbes in the bifidobacterium longum, preferred bifidobacterium adolescentis, bifidobacterium infantis equal proportion Mixed Microbes.

5. the preparation method of composite probiotics ferment Chinese herbal medicine active-fermented broth according to claim 1, it is characterized in that, compound sugar is fructose oligosaccharides, soyabean oligosaccharides, lactulo-oligosaccharide, the isomaltose compound sugar, GOS, mannan-oligosaccharides, gentian oligose, the wood sugar compound sugar, one or more in the inulin.

6. the preparation method of composite probiotics ferment Chinese herbal medicine active-fermented broth according to claim 1 is characterized in that, tealeaves is oolong tea, black tea, one or more in the green tea.