CN103007343B - Hard tissue repair and substitute material and preparation method thereof - Google Patents
Hard tissue repair and substitute material and preparation method thereof Download PDFInfo
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- CN103007343B CN103007343B CN201310015917.4A CN201310015917A CN103007343B CN 103007343 B CN103007343 B CN 103007343B CN 201310015917 A CN201310015917 A CN 201310015917A CN 103007343 B CN103007343 B CN 103007343B
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Abstract
The invention belongs to the technical field of a biological material and provides a hard tissue repair and substitute material and a preparation method thereof. The hard tissue repair and substitute material comprises biphasic calcium phosphate (BCP) in which polyamino acid (PAA) is added. The hard tissue repair and substitute material with good biological activity and enough mechanical strength is obtained by adding the polyamino acid to improve the mechanical strength of the biphasic calcium phosphate, thereby the problem that the single biphasic calcium phosphate has lower mechanical strength, is difficult to serve as the bone repair and substitute material to play a role in a structural support and is largely restricted in clinical application is solved. The preparation method is simple and lower in cost and has stronger practical applicability and higher popularization and application value.
Description
Technical field
The invention belongs to technical field of biological materials, relate in particular to a kind of hard tissue repair and substitution material and preparation method thereof.
Background technology
At present hard tissue repair and alternative biomaterial are various in style, but can successfully apply to clinical seldom, main cause is to make the biological activity of biomaterial and mechanical strength reach good balance, particularly on mechanical strength, does not often reach the requirement of clinical practice.Biphase calcium phosphor pottery (biphasic calcium phosphate, BCP) bioactive materials being formed by hydroxyapatite and bata-tricalcium phosphate, combine hydroxyapatite (hydroxyapatite, HA) high strength, high bioactivity, stability and bata-tricalcium phosphate (β-tricalcium phosphate, β-TCP) absorption degradation characteristic, BCP has obtained a large amount of further investigations and extensive use for a long time as bone renovating material.BCP has good osteoinductive and bone conductibility, can be processed into loose structure, and can regulate by loose structure degradation property and the mechanical strength of material.But the mechanical strength of single biphase calcium phosphor pottery (BCP) is lower, only 0.5 ~ 5MPa, is difficult to play as bone reparation and substitution material the effect of structural support, makes its clinical practice be subject to very big restriction.
Summary of the invention
The invention provides a kind of hard tissue repair and substitution material and preparation method thereof, the mechanical strength that is intended to solve single biphase calcium phosphor pottery is lower, is difficult to play the effect of structural support and clinical practice is subject to the greatly problem of restriction as bone reparation and substitution material.
The object of the present invention is to provide a kind of hard tissue repair and substitution material, this hard tissue repair and substitution material are made up of the biphase calcium phosphor pottery (BCP) that has added polyamino acid (PAA).
Another object of the present invention is to provide the preparation method of a kind of hard tissue repair and substitution material, this preparation method comprises the following steps:
Step 1, joins 63.16g 6-aminocaprolc acid, 2.76g proline, 2.68g alanine, 2.96g phenylalanine, 1.8g lysine, 3.00g hydroxyproline and 100ml water in the three-necked bottle of 250ml with agitating device and nitrogen protection device;
Step 2, opens nitrogen protection and stirring, is progressively warming up to 200 DEG C, is warming up to 210 DEG C after having dewatered, and reactant is all melt into bright orange transparent melt at this temperature;
Step 3; after molten monomer, be warming up to 220 DEG C and start polyreaction 3 hours; and to add 49.89g content be 40% biophasic calcium phosphate ceramic, be warming up to 230 DEG C of reactions 3 hours, after reaction finishes, under nitrogen protection, cool to room temperature obtains block hard tissue repair and substitution material.
Hard tissue repair provided by the invention and substitution material and preparation method thereof, by adding the mechanical strength of polyamino acid improvement biphase calcium phosphor pottery, the hard tissue repair and the substitution material that have the active and enough mechanical strengths of good biological concurrently are obtained, the mechanical strength that has solved single biphase calcium phosphor pottery is lower, be difficult to play the effect of structural support and clinical practice is subject to the greatly problem of restriction as bone reparation and substitution material, this preparation method is simple, cost is lower, practical, there is stronger propagation and employment and be worth.
Brief description of the drawings
Fig. 1 is the realization flow figure of the preparation method of the hard tissue repair that provides of the embodiment of the present invention and substitution material.
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearer, below in conjunction with drawings and Examples, the present invention is described in further detail.Should be appreciated that specific embodiment described herein is only in order to explain the present invention, and be not used in restriction invention.
The object of the present invention is to provide a kind of hard tissue repair and substitution material, this hard tissue repair and substitution material are made up of the biphase calcium phosphor pottery (BCP) that has added polyamino acid (PAA).
Fig. 1 shows the realization flow of the preparation method of hard tissue repair that the embodiment of the present invention provides and substitution material.
This preparation method comprises the following steps:
In step S101,63.16g 6-aminocaprolc acid, 2.76g proline, 2.68g alanine, 2.96g phenylalanine, 1.8g lysine, 3.00g hydroxyproline and 100ml water are joined in the three-necked bottle of 250ml with agitating device and nitrogen protection device;
In step S102, open nitrogen protection and stirring, be progressively warming up to 200 DEG C, after having dewatered, be warming up to 210 DEG C, reactant is all melt into bright orange transparent melt at this temperature;
In step S103; after molten monomer, be warming up to 220 DEG C and start polyreaction 3 hours; and to add 49.89g content be 40% biophasic calcium phosphate ceramic, be warming up to 230 DEG C of reactions 3 hours, after reaction finishes, under nitrogen protection, cool to room temperature obtains block hard tissue repair and substitution material.
Below in conjunction with drawings and the specific embodiments, application principle of the present invention is further described.
The present invention intends the mechanical strength by adding polyamino acid (PAA) improvement biphase calcium phosphor pottery, becomes the hard tissue repair and the substitution material that have the active and enough mechanical strengths of good biological concurrently
Fig. 1 shows the realization flow of the preparation method of hard tissue repair that the embodiment of the present invention provides and substitution material; by 63.16g 6-aminocaprolc acid; 2.76g proline; 2.68g alanine; 2.96g phenylalanine; 1.8g lysine; 3.00g hydroxyproline and 100ml water join in the three-necked bottle of 250ml with agitating device and nitrogen protection device; open nitrogen protection and stirring; progressively be warming up to 200 DEG C; after having dewatered, be warming up to 210 DEG C, all meltings of reactant at this temperature, become bright orange transparent melt.After molten monomer, be warming up to 220 DEG C and start polyreaction 3h.Now, add 49.89g content to be about the biophasic calcium phosphate ceramic of 40 %, be warming up to 230 DEG C of reaction 3h, after reaction finishes, under nitrogen protection, cool to room temperature obtains block composite.
The hard tissue repair that the embodiment of the present invention provides and substitution material and preparation method thereof, by adding the mechanical strength of polyamino acid improvement biphase calcium phosphor pottery, the hard tissue repair and the substitution material that have the active and enough mechanical strengths of good biological concurrently are obtained, the mechanical strength that has solved single biphase calcium phosphor pottery is lower, be difficult to play the effect of structural support and clinical practice is subject to the greatly problem of restriction as bone reparation and substitution material, this preparation method is simple, cost is lower, practical, there is stronger propagation and employment and be worth.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any amendments of doing within the spirit and principles in the present invention, be equal to and replace and improvement etc., within all should being included in protection scope of the present invention.
Claims (1)
1. a preparation method for hard tissue repair and substitution material, is characterized in that, this hard tissue repair and substitution material are made up of the biphase calcium phosphor pottery (BCP) that has added polyamino acid (PAA);
The preparation method of this hard tissue repair and substitution material comprises the following steps:
Step 1, joins 63.16g6-aminocaproic acid, 2.76g proline, 2.68g alanine, 2.96g phenylalanine, 1.8g lysine, 3.00g hydroxyproline and 100ml water in the three-necked bottle of 250ml with agitating device and nitrogen protection device;
Step 2, opens nitrogen protection and stirring, is progressively warming up to 200 DEG C, is warming up to 210 DEG C after having dewatered, and reactant is all melt into bright orange transparent melt at this temperature;
Step 3; after molten monomer, be warming up to 220 DEG C and start polyreaction 3 hours; and to add 49.89g content be 40% biophasic calcium phosphate ceramic, be warming up to 230 DEG C of reactions 3 hours, after reaction finishes, under nitrogen protection, cool to room temperature obtains block hard tissue repair and substitution material.
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| CN105288748B (en) * | 2015-12-03 | 2018-01-16 | 广东省微生物研究所 | A kind of anti-infective calcium phosphate composite bone cement material and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20080102097A1 (en) * | 2006-10-31 | 2008-05-01 | Zanella John M | Device and method for treating osteolysis using a drug depot to deliver an anti-inflammatory agent |
| CN101342384A (en) * | 2008-08-25 | 2009-01-14 | 四川国纳科技有限公司 | Composite polymer bone-renovation material containing ceramic component and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20080102097A1 (en) * | 2006-10-31 | 2008-05-01 | Zanella John M | Device and method for treating osteolysis using a drug depot to deliver an anti-inflammatory agent |
| CN101342384A (en) * | 2008-08-25 | 2009-01-14 | 四川国纳科技有限公司 | Composite polymer bone-renovation material containing ceramic component and preparation method thereof |
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