CN103004897A - Efficient biological bactericide - Google Patents

Abstract

The present invention relates to an efficient biological bactericide, which is mainly provided for general-purpose sterilization and disinfection of medical institution air, object surfaces, and skin, and can be widely used for disinfection in homes, hotels, shopping malls, schools and other public places. The efficient biological bactericide has the following characteristics that: the efficient biological bactericide has a significant disinfection and sterilization effect, and provides significant killing effects for common pathogenic bacteria in hospitals; a use rang is wide, and the efficient biological bactericide is suitable for skin sterilization and disinfection of all areas, various environmental sites and various people; the efficient biological bactericide has characteristics of no toxicity, no stimulation, no corrosion, no harm on human body, stable chemical property, and strong sterilization persistence, and can be filled into a small bottle to be carried so as to easy wash; and the efficient biological bactericide is a biological agent and further has a green environmental protection characteristic.

Description

Efficient biologic germicide

Technical field

The present invention relates to a kind of efficient biologic germicide, its effective sterilization component is that polyhexamethylene guanide, double-chain quaternary ammonium salt, N-trimethyl chitin, dna unwinding enzyme and Chinese herbal medicine coptis root, bitter leaves root elite liquid phase are composite, the efficient biologic germicide that is prepared from through special process.Be mainly used in the general sterilizing of medical institutions' air, body surface, skin, but also extensive use aspect the sterilization of the public places such as family, hotel, market, school.Along with people's growth in the living standard, the development of science and technology, people also have higher requirement to environmental sanitary quality when enjoying material life.The various pathogenic bacteria that distributing in people's the living environment, thus the health of harm humans propagated by approach such as air, body surface, contacts.In medical institutions, be that a patient assembles, the pathogenic microorganisms breeding is local rapidly especially.The contact that the contact of pathogenic bacteria by air, body surface, medical personnel's hand, patient use Public Goods and fast, infect widely.Therefore, the sterilization of living environment is paid much attention to by people.In order effectively to control the propagation of pathogenic bacteria, the sanitary cleaning of living environment, the health of people's health, a kind of bactericide efficient, nontoxic, non-stimulated, that have no side effect, conveniently use without burn into is the eager demands of people.

Background technology

In recent years, the outburst of the acute epidemic situations such as SARS and first type HINI makes people to the sterilization of living environment darker understanding arranged; Cause the rising of the direct death straight line of patient along with hospital infection, the sterilization of hospital has caused people's fear.Statistics according to Center for Disease Control and Prevention, the U.S. has 2～300 ten thousand patient that hospital infection occurs every year, directly cause annual 88000 routine deaths, be used for the treatment of hospital infection and annual hospital need spend 4,500,000,000, effectively controlling hospital infection has become very urgent and important problem.Therefore, started the again peak of using the disinfection product.The kind of existing bactericide is a lot of on the market, and bactericidal property differs, and active ingredient mostly is chlorine, iodine, aldehyde, alcohol, acids etc.Wherein use most often chlorine-containing disinfectant, the favor that it is wide because of fungicidal spectrum, effect is rapid, bactericidal effect reliably is subject to people, but in use character is unstable, be corrosive, available chlorine is easily lost, on fabric discoloration arranged, be subject to the machine thing, the shortcoming of pH impact, brought inconvenience to the user.In hospital, air, body surface can adopt ultraviolet ray, ozone to carry out sterilization, but can only be in the situation that unmanned, airtight carrying out not only use inconvenience, and secondary pollution can damage to patient, old young colony.Therefore, people wish always a kind of easy to use, to the birth of bactericide of human body without injury, noresidue.The object of the present invention is to provide a kind of efficient, nontoxic, easy to use, all spendable general-purpose highly effective biological bactericide in each place.

Summary of the invention

Main points of the present invention are to select biological prescription, with the synergy that Chinese herbal medicine elite liquid phase is composite various pathogenic bacteria are carried out quick killing action, effectively kill and control the propagation of pathogenic microorganisms; And contained active ingredient does not have toxicity, is breathed absorption by people in air, can play the effect that improves resistance.

The prescription following (component and percentage by weight % thereof) that the present invention selects: polyhexamethylene guanide 8.0-10.0, double-chain quaternary ammonium salt 6.0-8.0, N-trimethyl chitin 3.0-5.0, dna unwinding enzyme 6.0-7.0, coptis root Essence 4.0-5.0, bitter leaves root Essence 3.0-4.0, purify waste water to 100.

Polyhexamethylene guanide becomes electropositive, therefore be easy to usually be electronegative each bacterioid, viral absorption, thereby the splitting function that has suppressed bacterial virus, make bacterial virus lose fecundity and add that the thin polymer film that forms with other material polymerizations has stopped up the respiration channel of microorganism, is choked to death rapidly microorganism.Have has a broad antifungal spectrum, all effective to Gram-positive and negative bacterium and mould, have efficient, to skin nonirritant, avirulence, non-corrosive characteristics.

Double-chain quaternary ammonium salt adopts a connection base that two traditional quaternary ammonium salt molecules are linked up, so that each compound molecule contains two hydrophilic groups and two hydrophobic groups, and the N ion of two positive charges.Have larger surface-active, owing in the molecule two positively charged N being arranged, more be conducive to biocide molecules in the absorption of bacterium surface, thereby change the permeability of cell wall, thalline is broken; After bactericide is adsorbed onto the thalline surface, be conducive to lipoid layer and albumin layer that hydrophobic group and hydrophilic group go deep into respectively somatic cells, cause enzyme to lose activity; In addition, introduce the atoms such as s, N in chain bridge, synergy makes the bi-quaternary ammonium salt compounds have stronger sterilizing ability.Organic diammonium compound and traditional mono-quaternaries Compound Phase ratio have stronger anti-microbial property and lower toxicity.

The N-trimethyl chitin is the derivative of shitosan, interacts with the electronegative side chain of the large biological molecule of pathogen cell surface, forms polymer, can affect the growth of pathogen and then inhibition pathogen; Also can directly enter the cell nucleus of pathogen, what be combined mRNA by affecting pathogen and protein with DNA synthesizes to suppress its breeding.

Dna unwinding enzyme acts on hydrogen bond between two dna single chains, accelerates the dna double chain and becomes two independent chains, and the dna replication dna of bacterium does not but have enough ligases to copy, and affects the normal replication of DNA of bacteria, and the anti-bacteria breeding loses activity.

The pure Chinese herbal medicine Essence that extracts from coptis root, bitter leaves root all has broad-spectrum antibacterial action, various bacteria, tubercle bacillus, virus, fungi, protozoon etc. is had suppress or killing action.Coptis root can destroy bacterial structure, anti-bacteria glycometabolism, suppress the synthetic of nucleic acid, protein, thus kill bacteria.The trace elements such as several amino acids, vitamin and zinc, manganese, rubidium that contain needed by human in the bitter leaves to not injury of human body, the bitter leaves Essence of trace is breathed absorption by people in air after, have the effect that improves body immunity.

The preparation method of product of the present invention is:

(1) by proportioning polyhexamethylene guanide and double-chain quaternary ammonium salt are added in the aqueous solution, stir, form even mixed liquor;

(2) the N-trimethyl chitin is dissolved in proportion purifies waste water, mix and add in the mentioned solution;

(3) add dna unwinding enzyme by proportioning, deionized water adds to 100, stirs to make biological fluids;

(4) respectively coptis root, bitter leaves are obtained Essence through cleaning, dry, pulverize, extracting;

(5) two kinds of Chinese herbal medicine Essences are composite in proportion, join in the biological fluids, mix;

(6) leave standstill, packing, warehouse-in.

The present invention has the following advantages: (1) sterilization effect is remarkable, and is particularly remarkable to killing of common pathogen in the hospital; (2) scope of application is wide, is suitable for the disinfection of every field, various environment place and various crowds' skin; (3) nontoxic, non-stimulated, non-corrosiveness, harmless; (4) this product chemical property is very stable, and the sterilization continuation is strong; (5) can fill with bottle and carry, be convenient to flushing.(6) biologic product, environmental protection.

Embodiment

The present invention is described in further detail below in conjunction with embodiment:

Be configured according to following table institute column data (percentage by weight %) and affiliated step thereof:

Prescription one: polyhexamethylene guanide 8.0-10.0, double-chain quaternary ammonium salt 6.0-8.0, N-trimethyl chitin 3.0-5.0, dna unwinding enzyme 6.0-7.0, coptis root Essence 4.0-5.0, bitter leaves root Essence 3.0-4.0, purify waste water to 100.

Prescription two:

Polyhexamethylene guanide 8.0-9.0, double-chain quaternary ammonium salt 6.0-7.0, N-trimethyl chitin 3.0-4.0, dna unwinding enzyme 6.0-6.5, coptis root Essence 4.0-4.5, bitter leaves root Essence 3.0-3.5, purify waste water to 100.

Prescription three:

Polyhexamethylene guanide 9.0-10.0, double-chain quaternary ammonium salt 7.0-8.0, N-trimethyl chitin 4.0-5.0, dna unwinding enzyme 6.5-7.0, coptis root Essence 4.5-5.0, bitter leaves root Essence 3.5-4.0, purify waste water to 100.

Claims (2)

1. the present invention relates to a kind of efficient biologic germicide, it is characterized in that having following prescription (component and percentage by weight % thereof): polyhexamethylene guanide 8.0-10.0; Double-chain quaternary ammonium salt 6.0-8.0; N-trimethyl chitin 3.0-5.0; Dna unwinding enzyme 6.0-7.0; Coptis root Essence 4.0-5.0; Bitter leaves root Essence 3.0-4.0; Purify waste water to 100.

2. the preparation method of the described efficient biologic germicide of claim 1 is characterized in that having following steps:

(1) by proportioning polyhexamethylene guanide and double-chain quaternary ammonium salt are added in the aqueous solution, stir, form even mixed liquor;

(2) the N-trimethyl chitin is dissolved in proportion purifies waste water, mix and add in the mentioned solution;

(3) add dna unwinding enzyme by proportioning, deionized water adds to 100, stirs to make biological fluids;

(4) respectively coptis root, bitter leaves are obtained Essence through cleaning, dry, pulverize, extracting;

(5) two kinds of Chinese herbal medicine Essences are composite in proportion, join in the biological fluids, mix;

(6) leave standstill, packing, warehouse-in.