CN102988665B - 一种妇科调经片的制备方法及应用 - Google Patents
一种妇科调经片的制备方法及应用 Download PDFInfo
- Publication number
- CN102988665B CN102988665B CN201210378259.0A CN201210378259A CN102988665B CN 102988665 B CN102988665 B CN 102988665B CN 201210378259 A CN201210378259 A CN 201210378259A CN 102988665 B CN102988665 B CN 102988665B
- Authority
- CN
- China
- Prior art keywords
- extraction
- preparation
- tablets
- fuke tiaojing
- ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title abstract description 11
- 230000005906 menstruation Effects 0.000 title abstract description 6
- 230000001105 regulatory effect Effects 0.000 title abstract description 5
- 238000002360 preparation method Methods 0.000 claims abstract description 25
- 239000003814 drug Substances 0.000 claims abstract description 24
- 235000021419 vinegar Nutrition 0.000 claims abstract description 19
- 239000000052 vinegar Substances 0.000 claims abstract description 19
- 238000000874 microwave-assisted extraction Methods 0.000 claims abstract description 11
- 238000000194 supercritical-fluid extraction Methods 0.000 claims abstract description 10
- 208000002454 Nasopharyngeal Carcinoma Diseases 0.000 claims abstract description 8
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims abstract description 8
- 201000011216 nasopharynx carcinoma Diseases 0.000 claims abstract description 8
- 241000218176 Corydalis Species 0.000 claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 55
- 238000000605 extraction Methods 0.000 claims description 19
- 239000000284 extract Substances 0.000 claims description 17
- 229940079593 drug Drugs 0.000 claims description 13
- 239000007788 liquid Substances 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 6
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 6
- 229920002472 Starch Polymers 0.000 claims description 5
- 230000000274 adsorptive effect Effects 0.000 claims description 5
- 229940126678 chinese medicines Drugs 0.000 claims description 5
- 230000006837 decompression Effects 0.000 claims description 5
- 239000003480 eluent Substances 0.000 claims description 5
- 238000010828 elution Methods 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 5
- 238000004064 recycling Methods 0.000 claims description 5
- 229920005989 resin Polymers 0.000 claims description 5
- 239000011347 resin Substances 0.000 claims description 5
- 239000008107 starch Substances 0.000 claims description 5
- 235000019698 starch Nutrition 0.000 claims description 5
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 abstract description 9
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 abstract description 9
- 229940114124 ferulic acid Drugs 0.000 abstract description 9
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 abstract description 9
- 235000001785 ferulic acid Nutrition 0.000 abstract description 9
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 abstract description 9
- 230000002401 inhibitory effect Effects 0.000 abstract description 3
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 241000132012 Atractylodes Species 0.000 abstract 1
- 240000004670 Glycyrrhiza echinata Species 0.000 abstract 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 abstract 1
- 241000212322 Levisticum officinale Species 0.000 abstract 1
- 241000736199 Paeonia Species 0.000 abstract 1
- 244000236658 Paeonia lactiflora Species 0.000 abstract 1
- 235000008598 Paeonia lactiflora Nutrition 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 244000126002 Ziziphus vulgaris Species 0.000 abstract 1
- 239000001645 levisticum officinale Substances 0.000 abstract 1
- 229940010454 licorice Drugs 0.000 abstract 1
- 229960004756 ethanol Drugs 0.000 description 21
- 238000002474 experimental method Methods 0.000 description 8
- 239000000243 solution Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 6
- 239000000047 product Substances 0.000 description 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- 239000013558 reference substance Substances 0.000 description 4
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 230000010261 cell growth Effects 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 239000012531 culture fluid Substances 0.000 description 3
- 229960000935 dehydrated alcohol Drugs 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- WEEMDRWIKYCTQM-UHFFFAOYSA-N 2,6-dimethoxybenzenecarbothioamide Chemical compound COC1=CC=CC(OC)=C1C(N)=S WEEMDRWIKYCTQM-UHFFFAOYSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 229920002334 Spandex Polymers 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000010165 autogamy Effects 0.000 description 1
- 238000010009 beating Methods 0.000 description 1
- FCPVYOBCFFNJFS-LQDWTQKMSA-M benzylpenicillin sodium Chemical compound [Na+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1 FCPVYOBCFFNJFS-LQDWTQKMSA-M 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010219 correlation analysis Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000012738 dissolution medium Substances 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000004900 laundering Methods 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- JWHHANVGNNWIRI-UHFFFAOYSA-N methanol phosphoric acid hydrate Chemical compound O.OC.OP(O)(O)=O JWHHANVGNNWIRI-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- YTJSFYQNRXLOIC-UHFFFAOYSA-N octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[SiH3] YTJSFYQNRXLOIC-UHFFFAOYSA-N 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000004759 spandex Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 229960002385 streptomycin sulfate Drugs 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210378259.0A CN102988665B (zh) | 2012-10-08 | 2012-10-08 | 一种妇科调经片的制备方法及应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210378259.0A CN102988665B (zh) | 2012-10-08 | 2012-10-08 | 一种妇科调经片的制备方法及应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102988665A CN102988665A (zh) | 2013-03-27 |
CN102988665B true CN102988665B (zh) | 2014-01-08 |
Family
ID=47918096
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201210378259.0A Expired - Fee Related CN102988665B (zh) | 2012-10-08 | 2012-10-08 | 一种妇科调经片的制备方法及应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102988665B (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103705683A (zh) * | 2013-12-22 | 2014-04-09 | 青岛琴诚医药技术有限公司 | 一种四消丸的制备方法及应用 |
CN103656600B (zh) * | 2013-12-22 | 2016-03-23 | 李梅 | 一种十二温经丸的制备方法及应用 |
CN103656016B (zh) * | 2013-12-22 | 2016-03-23 | 李梅 | 一种苏子降气丸的制备方法及应用 |
CN104324339B (zh) * | 2014-11-29 | 2015-09-09 | 江志慧 | 一种用于治疗和护理***的药物及制备方法 |
CN104888086A (zh) * | 2015-06-16 | 2015-09-09 | 广东恒诚制药有限公司 | 一种复方春砂颗粒的制备方法及应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101057926A (zh) * | 2005-11-04 | 2007-10-24 | 北京奇源益德药物研究所 | 治疗妇科疾病的妇科调经制剂及其制法和质量控制方法 |
CN102397461A (zh) * | 2011-11-27 | 2012-04-04 | 苏州派腾生物医药科技有限公司 | 一种妇康宁片的制备方法 |
-
2012
- 2012-10-08 CN CN201210378259.0A patent/CN102988665B/zh not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101057926A (zh) * | 2005-11-04 | 2007-10-24 | 北京奇源益德药物研究所 | 治疗妇科疾病的妇科调经制剂及其制法和质量控制方法 |
CN102397461A (zh) * | 2011-11-27 | 2012-04-04 | 苏州派腾生物医药科技有限公司 | 一种妇康宁片的制备方法 |
Non-Patent Citations (4)
Title |
---|
喻定开.妇科调经颗粒的制剂研究.《中国优秀博硕士学位论文全文数据库(硕士) 医药卫生科技辑》.2006,(第11期),E057-234. * |
国家药典委员会.妇科调经片.《中华人民共和国药典一部》.化学工业出版社,2010,(第2010年版),729. * |
用均匀设计CO2超临界混合萃取当归、川芎、香附中挥发性成分及提取物β-CD包合的研究;阿古拉等;《现代中药研究与实践》;20050228;第19卷(第1期);57-58、64 * |
阿古拉等.用均匀设计CO2超临界混合萃取当归、川芎、香附中挥发性成分及提取物β-CD包合的研究.《现代中药研究与实践》.2005,第19卷(第1期),57-58、64. |
Also Published As
Publication number | Publication date |
---|---|
CN102988665A (zh) | 2013-03-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102988723B (zh) | 一种中成药的制备方法及应用 | |
CN102988526B (zh) | 一种白灵片的制备方法及应用 | |
CN102988667B (zh) | 一种调经活血片的制备方法及应用 | |
CN102973667A (zh) | 一种感冒退烧片的制备方法及应用 | |
CN102988577B (zh) | 一种清脑降压片的制备方法及应用 | |
CN102988665B (zh) | 一种妇科调经片的制备方法及应用 | |
CN102988612B (zh) | 一种清火片的制备方法及应用 | |
CN102988502B (zh) | 一种得生片的制备方法及应用 | |
CN102988545B (zh) | 一种萸连片的制备方法及应用 | |
CN103028005B (zh) | 一种腰痛片的制备方法及应用 | |
CN102988489B (zh) | 一种利鼻片在制备抑制人黑色素瘤细胞m14细胞增殖药物中的应用 | |
CN102988550B (zh) | 一种芩连片的制备方法及应用 | |
CN102988479B (zh) | 一种清眩片的制备方法及应用 | |
CN102988509B (zh) | 一种接骨片的制备方法及应用 | |
CN102836381A (zh) | 一种安中片的制备方法及应用 | |
CN102988611B (zh) | 一种降压片的制备方法及应用 | |
CN102988614A (zh) | 一种消炎片的制备方法及应用 | |
CN102988501B (zh) | 一种痢必灵片的制备方法及应用 | |
CN102988500B (zh) | 一种复方胆通片的制备方法及应用 | |
CN102988881B (zh) | 一种通脉灵片的制备方法及应用 | |
CN102988522B (zh) | 一种脑得生片的制备方法及应用 | |
CN102988748B (zh) | 一种养阴降糖片的制备方法及应用 | |
CN102988749B (zh) | 一种中成药的制备方法及应用 | |
CN102988691B (zh) | 一种健肝片的制备方法及应用 | |
CN102988576B (zh) | 一种九味羌活片的制备方法及应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: ZHANGQIU MATERNAL AND CHILD CARE SERVICE CENTRE Free format text: FORMER OWNER: BIAN YUPING Effective date: 20131125 |
|
C41 | Transfer of patent application or patent right or utility model | ||
C53 | Correction of patent for invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Zhang Zhiguo Inventor after: Yu Qingwen Inventor after: Zhang Xia Inventor before: The inventor has waived the right to be mentioned |
|
COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: REQUEST NOT TO RELEASE THE NAME TO: ZHANG ZHIGUO YU QINGWEN ZHANG XIA Free format text: CORRECT: ADDRESS; FROM: 211224 NANJING, JIANGSU PROVINCE TO: 250200 JINAN, SHANDONG PROVINCE |
|
TA01 | Transfer of patent application right |
Effective date of registration: 20131125 Address after: 250200 Shandong city of Ji'nan province Zhangqiu Tang Road No. 1281 Applicant after: Zhangqiu Maternal and Child Care Service Centre Address before: Lishui County of Nanjing City, Jiangsu province 211224 Jing Qiao Zhen Chen Biancun Applicant before: Bian Yuping |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140108 Termination date: 20191008 |
|
CF01 | Termination of patent right due to non-payment of annual fee |