CN102988470A - 一种治疗母畜产后感染的长效混悬子宫灌注剂及制备工艺 - Google Patents
一种治疗母畜产后感染的长效混悬子宫灌注剂及制备工艺 Download PDFInfo
- Publication number
- CN102988470A CN102988470A CN2012105884423A CN201210588442A CN102988470A CN 102988470 A CN102988470 A CN 102988470A CN 2012105884423 A CN2012105884423 A CN 2012105884423A CN 201210588442 A CN201210588442 A CN 201210588442A CN 102988470 A CN102988470 A CN 102988470A
- Authority
- CN
- China
- Prior art keywords
- injection
- long
- female animal
- extract
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241001465754 Metazoa Species 0.000 title claims abstract description 27
- 230000010412 perfusion Effects 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- 208000015181 infectious disease Diseases 0.000 title abstract description 4
- 230000007774 longterm Effects 0.000 title abstract 5
- 239000000725 suspension Substances 0.000 title abstract 5
- 238000002347 injection Methods 0.000 claims abstract description 44
- 239000007924 injection Substances 0.000 claims abstract description 44
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000000284 extract Substances 0.000 claims abstract description 19
- GSDSWSVVBLHKDQ-UHFFFAOYSA-N 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=C2)=O)=C3N2C(C)COC3=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims abstract description 18
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 18
- MGCCHNLNRBULBU-WZTVWXICSA-N flunixin meglumine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.C1=CC=C(C(F)(F)F)C(C)=C1NC1=NC=CC=C1C(O)=O MGCCHNLNRBULBU-WZTVWXICSA-N 0.000 claims abstract description 18
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229960000282 metronidazole Drugs 0.000 claims abstract description 18
- 229960001699 ofloxacin Drugs 0.000 claims abstract description 18
- 239000008215 water for injection Substances 0.000 claims abstract description 18
- 229960000469 flunixin meglumine Drugs 0.000 claims abstract description 17
- 208000020264 Puerperal Infection Diseases 0.000 claims description 19
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 17
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 17
- 229920003081 Povidone K 30 Polymers 0.000 claims description 17
- 239000009188 angelicae sinensis extract Substances 0.000 claims description 17
- 239000002994 raw material Substances 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
- 239000000243 solution Substances 0.000 claims description 7
- 239000000084 colloidal system Substances 0.000 claims description 6
- 238000005516 engineering process Methods 0.000 claims description 6
- 239000003643 water by type Substances 0.000 claims description 6
- 210000003022 colostrum Anatomy 0.000 claims description 3
- 235000021277 colostrum Nutrition 0.000 claims description 3
- 210000005224 forefinger Anatomy 0.000 claims description 3
- 238000007689 inspection Methods 0.000 claims description 3
- 238000004898 kneading Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000004576 sand Substances 0.000 claims description 3
- 239000011265 semifinished product Substances 0.000 claims description 3
- 210000003813 thumb Anatomy 0.000 claims description 3
- 238000009395 breeding Methods 0.000 abstract description 3
- 230000001488 breeding effect Effects 0.000 abstract description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract description 3
- 230000036541 health Effects 0.000 abstract description 2
- 210000004291 uterus Anatomy 0.000 abstract description 2
- 229960001484 edetic acid Drugs 0.000 abstract 2
- 241000382455 Angelica sinensis Species 0.000 abstract 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract 1
- 241000207925 Leonurus Species 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 230000012173 estrus Effects 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 8
- 230000000694 effects Effects 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 238000005457 optimization Methods 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 241000283690 Bos taurus Species 0.000 description 3
- 241001494479 Pecora Species 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 206010025482 malaise Diseases 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 241000193830 Bacillus <bacterium> Species 0.000 description 2
- 208000004145 Endometritis Diseases 0.000 description 2
- 206010046914 Vaginal infection Diseases 0.000 description 2
- 201000008100 Vaginitis Diseases 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000011020 pilot scale process Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 208000031504 Asymptomatic Infections Diseases 0.000 description 1
- 241000304886 Bacilli Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000606153 Chlamydia trachomatis Species 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 241000588921 Enterobacteriaceae Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000589248 Legionella Species 0.000 description 1
- 208000007764 Legionnaires' Disease Diseases 0.000 description 1
- 108060004795 Methyltransferase Proteins 0.000 description 1
- 241000204031 Mycoplasma Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 241000543821 Oestrus Species 0.000 description 1
- 206010058674 Pelvic Infection Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 206010037651 Pyometra Diseases 0.000 description 1
- 208000007893 Salpingitis Diseases 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 201000004171 acute endometritis Diseases 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229940038705 chlamydia trachomatis Drugs 0.000 description 1
- 208000030373 chronic endometritis Diseases 0.000 description 1
- 210000004246 corpus luteum Anatomy 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000000509 infertility Diseases 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 231100000535 infertility Toxicity 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 201000002765 pyometritis Diseases 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 239000000273 veterinary drug Substances 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
主要成份 | 处方1 | 处方2 | 处方3 | 处方4 | 处方5 |
氧氟沙星 | 2.5kg | 1.5 | 2 | 3 | 3.5 |
氟尼辛葡甲胺 | 0.5kg | 0.125 | 0.25 | 0.75 | 1.0 |
甲硝唑 | 0.25kg | 0.125 | 0.25 | 0.5 | 0.75 |
益母草提取物(注射级) | 0.5kg | 0.125 | 0.25 | 0.75 | 1.0 |
当归提取物(注射级) | 0.5kg | 0.125 | 0.25 | 0.75 | 1.0 |
PVP-K30 | 0.75kg | 0.25 | 0.5 | 1.0 | 1.25 |
PEG-400 | 10kg | 2 | 5 | 12 | 15 |
EDTA-2Na | 0.03kg | 0.03 | 0.03 | 0.03 | 0.03 |
注射用水 | 加至10万ml | 加至10万ml | 加至10万ml | 加至10万ml | 加至10万ml |
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210588442.3A CN102988470B (zh) | 2012-12-29 | 2012-12-29 | 一种治疗母畜产后感染的长效混悬子宫灌注剂及制备工艺 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210588442.3A CN102988470B (zh) | 2012-12-29 | 2012-12-29 | 一种治疗母畜产后感染的长效混悬子宫灌注剂及制备工艺 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102988470A true CN102988470A (zh) | 2013-03-27 |
CN102988470B CN102988470B (zh) | 2014-11-05 |
Family
ID=47917896
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201210588442.3A Active CN102988470B (zh) | 2012-12-29 | 2012-12-29 | 一种治疗母畜产后感染的长效混悬子宫灌注剂及制备工艺 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102988470B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103356690A (zh) * | 2013-06-09 | 2013-10-23 | 四川英格瑞生物科技有限公司 | 一种治疗母猪子***的注射剂及其制备方法 |
CN103385919A (zh) * | 2013-07-19 | 2013-11-13 | 福建奥姆龙动物药业有限公司 | 一种母猪产后消炎药物及其制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101310734A (zh) * | 2007-05-22 | 2008-11-26 | 史义林 | 用于治疗奶牛子***的中西药复方子宫灌注液 |
CN102698045A (zh) * | 2012-06-21 | 2012-10-03 | 武汉长江巨龙药业有限公司 | 一种治疗产后便秘的中药制剂 |
-
2012
- 2012-12-29 CN CN201210588442.3A patent/CN102988470B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101310734A (zh) * | 2007-05-22 | 2008-11-26 | 史义林 | 用于治疗奶牛子***的中西药复方子宫灌注液 |
CN102698045A (zh) * | 2012-06-21 | 2012-10-03 | 武汉长江巨龙药业有限公司 | 一种治疗产后便秘的中药制剂 |
Non-Patent Citations (1)
Title |
---|
李素华等: "益母草冲剂联合酚磺乙胺 氧氟沙星防治药物流产后出血的临床观察", 《中国药物与临床》 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103356690A (zh) * | 2013-06-09 | 2013-10-23 | 四川英格瑞生物科技有限公司 | 一种治疗母猪子***的注射剂及其制备方法 |
CN103356690B (zh) * | 2013-06-09 | 2015-02-25 | 四川英格瑞生物科技有限公司 | 一种治疗母猪子***的注射剂及其制备方法 |
CN103385919A (zh) * | 2013-07-19 | 2013-11-13 | 福建奥姆龙动物药业有限公司 | 一种母猪产后消炎药物及其制备方法 |
CN103385919B (zh) * | 2013-07-19 | 2015-07-15 | 福建奥姆龙生物工程有限公司 | 一种母猪产后消炎药物及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN102988470B (zh) | 2014-11-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103211997B (zh) | 一种抗菌抗病毒的中药组合物及其制备方法 | |
CN106727849A (zh) | 一种妇科凝胶 | |
CN102552769B (zh) | 一种治疗***炎的药物及其制备方法 | |
CN102988470B (zh) | 一种治疗母畜产后感染的长效混悬子宫灌注剂及制备工艺 | |
CN102000145B (zh) | 防治母畜子***的中西药复方灌注液及其制备方法 | |
CN106109587A (zh) | 一种修复女性***微生态平衡的药物组合物 | |
CN101606992B (zh) | 一种防治奶牛子***的复方中药灌注液及其制备方法 | |
CN104288222A (zh) | 一种治疗奶牛子***的纳米药物及其制备方法 | |
CN100369618C (zh) | 一种中药组合物在制备治疗妇科炎症药物中的应用 | |
CN110393768A (zh) | 一种母猪子宫消炎的组合中药灌注药物及其制备方法和应用 | |
CN102836120B (zh) | 一种兽用乳酸环丙沙星栓剂及其制备方法 | |
CN110227094B (zh) | 合欢花水提取物在制备防治妇科炎症性疾病外用药物中的应用 | |
CN106138369A (zh) | 一种防治动物子***的药物组合物及其制备方法 | |
CN103356690B (zh) | 一种治疗母猪子***的注射剂及其制备方法 | |
CN108261440B (zh) | 一种治疗母猪产后子***的软胶囊剂及其制备方法 | |
CN102552366B (zh) | 中药提取物组合的母畜子宫清洗液 | |
CN103463564B (zh) | 一种外用莪术油温敏凝胶及其制备方法 | |
CN104840420A (zh) | 一种用于奶牛的硫酸头孢喹肟子宫注入剂及其制备方法 | |
CN104815095A (zh) | 一种具有修复和恢复***微生态平衡的组合物 | |
CN104798727B (zh) | 一种保持蓝耳病整体抗体水平的中药组合物及引种方法 | |
CN104491222A (zh) | 一种治疗牛卵泡囊肿的中药及其制备方法 | |
CN103599437A (zh) | 一种治疗***炎的中药药液 | |
CN111588773B (zh) | 通过母猪服药防治新生仔猪腹泻的中药组合物及其应用 | |
CN101190181B (zh) | 单体纳米银卫生栓及其制作方法 | |
CN107496905A (zh) | 一种提高母畜生殖能力的中药组合物及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Long-term suspension uterine perfusion agent for treating female animal postpartum infection and preparation process Effective date of registration: 20180424 Granted publication date: 20141105 Pledgee: Anqiu Shandong rural commercial bank Limited by Share Ltd. Pledgor: WEIFANG FUBANG PHARMACEUTICAL Co.,Ltd. Registration number: 2018980000053 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20181017 Granted publication date: 20141105 Pledgee: Anqiu Shandong rural commercial bank Limited by Share Ltd. Pledgor: WEIFANG FUBANG PHARMACEUTICAL Co.,Ltd. Registration number: 2018980000053 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Long-term suspension uterine perfusion agent for treating female animal postpartum infection and preparation process Effective date of registration: 20181105 Granted publication date: 20141105 Pledgee: Anqiu Shandong rural commercial bank Limited by Share Ltd. Pledgor: WEIFANG FUBANG PHARMACEUTICAL Co.,Ltd. Registration number: 2018980000208 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20191107 Granted publication date: 20141105 Pledgee: Anqiu Shandong rural commercial bank Limited by Share Ltd. Pledgor: WEIFANG FUBANG PHARMACEUTICAL Co.,Ltd. Registration number: 2018980000208 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Long-term suspension uterine perfusion agent for treating female animal postpartum infection and preparation process Effective date of registration: 20191213 Granted publication date: 20141105 Pledgee: Anqiu Shandong rural commercial bank Limited by Share Ltd. Pledgor: WEIFANG FUBANG PHARMACEUTICAL Co.,Ltd. Registration number: Y2019370000120 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20210122 Granted publication date: 20141105 Pledgee: Anqiu Shandong rural commercial bank Limited by Share Ltd. Pledgor: WEIFANG FUBANG PHARMACEUTICAL Co.,Ltd. Registration number: Y2019370000120 |
|
CP03 | Change of name, title or address | ||
CP03 | Change of name, title or address |
Address after: 262199 South Neighborhood of Qingyun Mountain in Anqiu City, Weifang City, Shandong Province (Lijiabu, Dawenhe Tourism Development Zone) Patentee after: Shandong Yuanda Fubang Biotechnology Co.,Ltd. Country or region after: China Address before: 262100 Lijiabu, Dawenhe Tourism Development Zone, south of Qingyun Mountain, Anqiu City, Weifang City, Shandong Province Patentee before: WEIFANG FUBANG PHARMACEUTICAL Co.,Ltd. Country or region before: China |