CN102988424A - Spraying agent capable of accelerating animal wound healing, relieving pain and promoting tissue regeneration and preparation process of spraying agent - Google Patents
Spraying agent capable of accelerating animal wound healing, relieving pain and promoting tissue regeneration and preparation process of spraying agent Download PDFInfo
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- CN102988424A CN102988424A CN2012105888015A CN201210588801A CN102988424A CN 102988424 A CN102988424 A CN 102988424A CN 2012105888015 A CN2012105888015 A CN 2012105888015A CN 201210588801 A CN201210588801 A CN 201210588801A CN 102988424 A CN102988424 A CN 102988424A
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- wound healing
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- purified water
- sodium phosphate
- ethanol
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Abstract
The invention discloses a spraying agent capable of accelerating animal wound healing, relieving pain and promoting tissue regeneration and a preparation process of the spraying agent. The spraying agent comprises, by weight, 0.5-1kg of natural propolis, 2-5kg of povidone iodine, 0.5-2kg of borneol, 2-10kg of glycerol, 50kg of 98% alcohol, 0.04kg of dexamethasone sodium phosphate and a proper amount of purified water. By the aid of the scheme, the spraying agent is applicable to adjuvant treatment of herpes, variola, foot-and-mouth fester, hoof shell falling, blisters of lips and hoofs and the like for animals such as pigs, cattle, sheep, foxes and marten, local infection caused by hilum breakage, tail breakage, tail biting, ear tag marking, castration and traumas and dermatitis caused by various bacteria, parasites and the like, and simultaneously, the spraying agent can accelerate wound healing.
Description
Technical field
The present invention relates to a kind ofly to treat that animal skin festers, the new prescription of spraying and the preparation technology of wound healing, pain relieving granulation promoting, belong to the veterinary drug technical field.
Background technology
Animal mouth hoof festers, accident trauma, mutually the disease such as to bait common in breeding process, and often by due to many reasons such as antibacterial, virus, parasite, external factor, the lighter creates the district and enlarges and worsen the severe one threat to life.In order to reduce the secondary infection in later stage, accelerating wound healing plays the effect of pain relieving granulation promoting, impels the body quick recovery, improves the fertility performance of animal.Therefore, the fester medicine of wound of the rapid healing body surface of seeking a kind of the best has become a difficult problem in the animal and veterinary cultivation.The present invention is easy to use, has avoided other inconvenient route of administration, makes medicine directly act on wound face, can play rapidly the effect of anti-inflammation, pain relieving, granulation promoting, healing.
Summary of the invention
The problem to be solved in the present invention provides a kind of quick reparation wound, reduces secondary infection, pain relieving granulation promoting, finally reaches the Chinese and Western compound recipe spray agent of quick recovery and lifting fertility performance.
In order to address the above problem, the present invention by the following technical solutions:
A kind of spray that accelerates animal wound healing, pain relieving granulation promoting, this prescription is made by the raw material of following weight proportion:
Natural propolis 0.5-1kg; Povidone iodine 2-5kg; Borneolum Syntheticum 0.5-2kg; Glycerol 2-10kg; 98% ethanol 50kg; Dexamethasone sodium phosphate; 0.04kg; Purified water is an amount of.
Below be the present invention to the further optimization of such scheme:
Natural propolis 1kg; Povidone iodine 5kg; Borneolum Syntheticum 2kg; Glycerol 10kg; 98% ethanol 50kg; Dexamethasone sodium phosphate; 0.04kg; Purified water is an amount of.
Another kind of optimization:
Natural propolis 0.5kg; Povidone iodine 2kg; Borneolum Syntheticum 0.5-2kg; Glycerol 2-10kg; 98% ethanol 50kg; Dexamethasone sodium phosphate; 0.04kg; Purified water is an amount of.
Another kind of optimization:
Natural propolis 0.5kg; Povidone iodine 3kg; Borneolum Syntheticum 1kg; Glycerol 4kg; 98% ethanol 50kg; Dexamethasone sodium phosphate; 0.04kg; Purified water is an amount of.
Another kind of optimization:
Natural propolis 0.75kg; Povidone iodine 4kg; Borneolum Syntheticum 1.5kg; Glycerol 6kg; 98% ethanol 50kg; Dexamethasone sodium phosphate; 0.04kg; Purified water is an amount of.
Another kind of optimization: natural propolis 0.75kg; Povidone iodine 5kg; Borneolum Syntheticum 1.5kg; Glycerol 8kg; 98% ethanol 50kg; Dexamethasone sodium phosphate; 0.04kg; Purified water is an amount of.
The present invention also provides the preparation technology of the new prescription of a kind of above-mentioned spraying, and this technique may further comprise the steps:
A. add the natural propolis that crushes in advance with 98% ethanol 5kg first, form solution after soaking 24h, for subsequent use.
B. the surplus of recipe quantity ethanol is joined in the reserve liquid preparation A liquid.
C. load weighted povidone iodine, join in the glycerol of in advance load weighted recipe quantity, stir while adding, preparation B liquid.
D. the Borneolum Syntheticum of load weighted recipe quantity, add in the A liquid for preparing, stir while adding, preparation C liquid.
E. C liquid is slowly added in the B liquid of making, stir while adding, preparation D liquid.
F. the purified water that takes a morsel adds the dexamethasone sodium phosphate of recipe quantity, and it is fully dissolved.
G. dexamethasone sodium phosphate solution is slowly poured in the D liquid for preparing.
H. add to the 100L standardize solution with purified water at last, after the inspection of semifinished product was qualified, directly fill need not sterilized.
In the above-mentioned prescription:
1, natural propolis: be rich in flavone compound, acid, alcohol, phenol, aldehyde, ester, ethers and alkene, terpene, steroid and several amino acids, fatty acid, enzyme, vitamin, various trace elements etc., be described as " purple gold ", make it have the several functions such as antibiotic, antiinflammatory, antipruritic, antioxidation, enhancing immunity, convergence, granulation promoting, reparation wound mucosa and tissue.
2, povidone iodine: disinfection preservative, be used for suppurative dermatitis, cutaneous fungal infection, the slight burn and scald of small size, also be used for the sterilization of small size skin, mucosa wound.After its mechanism of action is this product contact wound surface or affected part, can depolymerization discharge contained iodine performance bactericidal action.Characteristics are little to tissue irritation, are applicable to skin, mucosa infection.
3, Borneolum Syntheticum: be rich in the sesquiterpenes such as Borneolum Syntheticum, Humuleno, beta-elemene, caryophyllene, the triterpenoids such as oleanolic acid, alphitolic acid, asiatic acid, dipterocarpol, dryobalanone, erythrodiol; Logical all keys, loose stagnated fire, removing nebula makes eye bright, reducing swelling and alleviating pain.
4, glycerol: the quickly-healing wound face also has the effect that slow release is protected cosolvent.
5,98% ethanol: organic solvent, the dissolving natural propolis discharges active ingredient fully; Be combined the effect that plays sterilizing with iodine.
6, dexamethasone sodium phosphate: use together with propolis, can make propolis produce stronger antibacterial and anti-inflammation functions; Reduce again simultaneously irritated effect.
7, purified water adds to 100L: excipient.
The present invention adopts such scheme, and herpes, variola, a mouthful hoof that is applicable to the animals such as pig, cattle, sheep, Vulpes ermine festers, coffin comes off and blister etc. appears in lip, hoof.The auxiliary treatment of the dermatitis that the local infection that disconnected umbilicus, docking, tail biting, labelling ear tag, castrating castration and wound cause and each bacterioid, parasite etc. cause simultaneously can accelerating wound healing.
The invention will be further described below by specific embodiment, but the present invention is not limited by following examples.
The specific embodiment
Embodiment, a kind of spray that accelerates animal wound healing, pain relieving granulation promoting, this prescription is made by the raw material of following weight proportion:
Because company is type of production company, make things convenient for company technique to transform, company's prescription all carries out with the pattern of large production, lab scale is 10:1, and pilot scale is 10:5, and more than prescription is pilot-scale experiment, prescription 1～5 is process of the test, finally filters out prescription 1 according to result of the test and is best prescription.
The preparation technology of above-mentioned prescription 1, this technique may further comprise the steps:
A. add the natural propolis 1kg that crushes in advance with 98% ethanol 5kg first, form solution after soaking 24h, for subsequent use.
B. the surplus of recipe quantity ethanol is joined in the reserve liquid preparation A liquid.
C. load weighted povidone iodine 5 kg, join among glycerol 10 kg of in advance load weighted recipe quantity, stir while adding, preparation B liquid.
D. the Borneolum Syntheticum 2kg of load weighted recipe quantity, add in the A liquid for preparing, stir while adding, preparation C liquid.
E. C liquid is slowly added in the B liquid of making, stir while adding, preparation D liquid.
F. the purified water that takes a morsel adds the dexamethasone sodium phosphate 0.04kg of recipe quantity, and it is fully dissolved.
G. dexamethasone sodium phosphate solution is slowly poured in the D liquid for preparing.
H. add to the 100L standardize solution with purified water at last, after the inspection of semifinished product was qualified, directly fill need not sterilized.
The present invention adopts best prescription 1, carries out following test:
(1) skin ulceration case 350 examples, random packet, and set up the blank group: 240 of morbidity pigs choosing 2 pig farms, 1 sick cattle of cattle farm 30 hairs, 2 sick sheep of sheep field 80 hairs, difference by specification after concentrating, infect the order of severity and size depending on affected part, pull out protective cover flicking nozzle, medicinal liquid is sprayed directly on to the affected part, spray 3～5 sprays at every turn; Moistening getting final product; Every day 2～3 times, be used in conjunction 3～5.
Result of the test is as follows: form 1
(2) exopathogenic factor wound 122 examples, docking piglet 40 examples, ablactational baby pig tail biting 12 examples, labelling ear tag 50 examples, castrating castration 20 examples, random packet, and set up the blank group, difference by specification after concentrating, infect the order of severity and size depending on affected part, pull out protective cover flicking nozzle, medicinal liquid is sprayed directly on to the affected part, spray 3～5 sprays at every turn; Moistening getting final product; Every day 2～3 times, be used in conjunction 3～5.
Result of the test: form 2
(3) skin problem 20 examples that cause of antibacterial and parasitic infection: antibacterial 8 examples, the parasites such as acarid 12 examples, random packet, and set up the blank group, the difference by specification infects the order of severity and size depending on affected part after concentrating, and pulls out protective cover flicking nozzle, medicinal liquid is sprayed directly on to the affected part, sprays 3～5 sprays at every turn; Moistening getting final product; Every day 2～3 times, be used in conjunction 3～5.
Result of the test: form 3
The present invention shakes up, gently so that inner composition is more even before using! Determine that depending on its affected part area and the order of severity spray is inferior! Infect the order of severity and size depending on affected part, medicinal liquid is sprayed directly on to the affected part, spray 3～5 sprays at every turn; Moistening getting final product; Every day 2～3 times, be used in conjunction 3～5.
Above-described embodiment be used for explaining inventive concept of the present invention and actual the use allly utilize this design and actual the use that the present invention is carried out the change of unsubstantiality, all should fall into protection scope of the present invention.
Claims (7)
1. spray that accelerates animal wound healing, pain relieving granulation promoting, it is characterized in that: this prescription is made by the raw material of following weight proportion:
Natural propolis 0.5-1kg; Povidone iodine 2-5kg; Borneolum Syntheticum 0.5-2kg; Glycerol 2-10kg; 98% ethanol 50kg; Dexamethasone sodium phosphate; 0.04kg; Purified water is an amount of.
2. a kind of spray that accelerates animal wound healing, pain relieving granulation promoting according to claim 1, it is characterized in that: this prescription is made by the raw material of following weight proportion:
Natural propolis 1kg; Povidone iodine 5kg; Borneolum Syntheticum 2kg; Glycerol 10kg; 98% ethanol 50kg; Dexamethasone sodium phosphate; 0.04kg; Purified water is an amount of.
3. a kind of spray that accelerates animal wound healing, pain relieving granulation promoting according to claim 1, it is characterized in that: this prescription is made by the raw material of following weight proportion:
Natural propolis 0.5kg; Povidone iodine 2kg; Borneolum Syntheticum 0.5-2kg; Glycerol 2-10kg; 98% ethanol 50kg; Dexamethasone sodium phosphate; 0.04kg; Purified water is an amount of.
4. a kind of spray that accelerates animal wound healing, pain relieving granulation promoting according to claim 1, it is characterized in that: this prescription is made by the raw material of following weight proportion:
Natural propolis 0.5kg; Povidone iodine 3kg; Borneolum Syntheticum 1kg; Glycerol 4kg; 98% ethanol 50kg; Dexamethasone sodium phosphate; 0.04kg; Purified water is an amount of.
5. a kind of spray that accelerates animal wound healing, pain relieving granulation promoting according to claim 1, it is characterized in that: this prescription is made by the raw material of following weight proportion:
Natural propolis 0.75kg; Povidone iodine 4kg; Borneolum Syntheticum 1.5kg; Glycerol 6kg; 98% ethanol 50kg; Dexamethasone sodium phosphate; 0.04kg; Purified water is an amount of.
6. a kind of spray that accelerates animal wound healing, pain relieving granulation promoting according to claim 1, it is characterized in that: this prescription is made by the raw material of following weight proportion:
Natural propolis 0.75kg; Povidone iodine 5kg; Borneolum Syntheticum 1.5kg; Glycerol 8kg; 98% ethanol 50kg; Dexamethasone sodium phosphate; 0.04kg; Purified water is an amount of.
7. preparation technology such as the spray of the arbitrary described acceleration animal of claim 1-6 wound healing, pain relieving granulation promoting, it is characterized in that: this technique may further comprise the steps:
A. add the natural propolis that crushes in advance with 98% ethanol 5kg first, form solution after soaking 24h, for subsequent use;
B. the surplus of recipe quantity ethanol is joined in the reserve liquid preparation A liquid;
C. load weighted povidone iodine, join in the glycerol of in advance load weighted recipe quantity, stir while adding, preparation B liquid;
D. the Borneolum Syntheticum of load weighted recipe quantity, add in the A liquid for preparing, stir while adding, preparation C liquid;
E. C liquid is slowly added in the B liquid of making, stir while adding, preparation D liquid;
F. the purified water that takes a morsel adds the dexamethasone sodium phosphate of recipe quantity, and it is fully dissolved;
G. dexamethasone sodium phosphate solution is slowly poured in the D liquid for preparing;
H. add to the 100L standardize solution with purified water at last, after the inspection of semifinished product was qualified, directly fill need not sterilized.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012105888015A CN102988424A (en) | 2012-12-29 | 2012-12-29 | Spraying agent capable of accelerating animal wound healing, relieving pain and promoting tissue regeneration and preparation process of spraying agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012105888015A CN102988424A (en) | 2012-12-29 | 2012-12-29 | Spraying agent capable of accelerating animal wound healing, relieving pain and promoting tissue regeneration and preparation process of spraying agent |
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| CN102988424A true CN102988424A (en) | 2013-03-27 |
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| CN2012105888015A Pending CN102988424A (en) | 2012-12-29 | 2012-12-29 | Spraying agent capable of accelerating animal wound healing, relieving pain and promoting tissue regeneration and preparation process of spraying agent |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3243503A1 (en) * | 2016-05-09 | 2017-11-15 | Petros Panagiotou | Therapeutic product for the treatment of pressure ulcers through the creation of a wound-healing crust upon spraying |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1535711A (en) * | 2003-04-11 | 2004-10-13 | 卫 肖 | Medicine composition for curing burn, scald and mucocutaneous ulcer |
| CN101400355A (en) * | 2006-03-14 | 2009-04-01 | Cls制药公司 | Ophthalmic compositions comprising povidone-iodine |
| CN101584715A (en) * | 2009-06-10 | 2009-11-25 | 中国人民解放军第三○二医院 | Spray for preventing and treating skin damnification and resisting infection |
| CN102333444A (en) * | 2009-02-27 | 2012-01-25 | 前瞻生物治疗公司 | Be used to treat mammiferous interior ear and use composition with external ear infection |
-
2012
- 2012-12-29 CN CN2012105888015A patent/CN102988424A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1535711A (en) * | 2003-04-11 | 2004-10-13 | 卫 肖 | Medicine composition for curing burn, scald and mucocutaneous ulcer |
| CN101400355A (en) * | 2006-03-14 | 2009-04-01 | Cls制药公司 | Ophthalmic compositions comprising povidone-iodine |
| CN102333444A (en) * | 2009-02-27 | 2012-01-25 | 前瞻生物治疗公司 | Be used to treat mammiferous interior ear and use composition with external ear infection |
| CN101584715A (en) * | 2009-06-10 | 2009-11-25 | 中国人民解放军第三○二医院 | Spray for preventing and treating skin damnification and resisting infection |
Non-Patent Citations (1)
| Title |
|---|
| 胡芳: "蜂胶治疗复发性口腔溃疡临床分析", 《广东牙病防治》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3243503A1 (en) * | 2016-05-09 | 2017-11-15 | Petros Panagiotou | Therapeutic product for the treatment of pressure ulcers through the creation of a wound-healing crust upon spraying |
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Application publication date: 20130327 |