CN102974025A - Disposable cervical dilator attached with medicine film - Google Patents
Disposable cervical dilator attached with medicine film Download PDFInfo
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- CN102974025A CN102974025A CN2012105328827A CN201210532882A CN102974025A CN 102974025 A CN102974025 A CN 102974025A CN 2012105328827 A CN2012105328827 A CN 2012105328827A CN 201210532882 A CN201210532882 A CN 201210532882A CN 102974025 A CN102974025 A CN 102974025A
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- CN
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- Prior art keywords
- medicine film
- dilator
- cervix
- cervical dilator
- lignocaine
- Prior art date
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- 239000003814 drug Substances 0.000 title claims abstract description 48
- 229960005015 local anesthetics Drugs 0.000 claims abstract description 8
- 210000003679 cervix uteri Anatomy 0.000 claims description 36
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims description 19
- 229960004194 lidocaine Drugs 0.000 claims description 19
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 14
- 229960004393 lidocaine hydrochloride Drugs 0.000 claims description 14
- YECIFGHRMFEPJK-UHFFFAOYSA-N lidocaine hydrochloride monohydrate Chemical compound O.[Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=CC=C1C YECIFGHRMFEPJK-UHFFFAOYSA-N 0.000 claims description 14
- -1 polyoxyethylene stearate Polymers 0.000 claims description 14
- 150000002148 esters Chemical class 0.000 claims description 13
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 claims description 11
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 5
- 239000000661 sodium alginate Substances 0.000 claims description 5
- 235000010413 sodium alginate Nutrition 0.000 claims description 5
- 229940005550 sodium alginate Drugs 0.000 claims description 5
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 229920000609 methyl cellulose Polymers 0.000 claims description 3
- 239000001923 methylcellulose Substances 0.000 claims description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 3
- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 claims description 2
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
- 229960003150 bupivacaine Drugs 0.000 claims description 2
- 229960002023 chloroprocaine Drugs 0.000 claims description 2
- VDANGULDQQJODZ-UHFFFAOYSA-N chloroprocaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1Cl VDANGULDQQJODZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000013256 coordination polymer Substances 0.000 claims description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 2
- 229960004288 levobupivacaine Drugs 0.000 claims description 2
- LEBVLXFERQHONN-INIZCTEOSA-N levobupivacaine Chemical compound CCCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-INIZCTEOSA-N 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 229960004919 procaine Drugs 0.000 claims description 2
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 claims description 2
- 229960001549 ropivacaine Drugs 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 229960002372 tetracaine Drugs 0.000 claims description 2
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 claims description 2
- 229940079593 drug Drugs 0.000 abstract description 5
- 230000036407 pain Effects 0.000 abstract description 4
- 238000002360 preparation method Methods 0.000 abstract description 4
- 230000008901 benefit Effects 0.000 abstract description 3
- 230000036760 body temperature Effects 0.000 abstract description 3
- 239000000546 pharmaceutical excipient Substances 0.000 abstract description 3
- 206010067484 Adverse reaction Diseases 0.000 abstract 1
- 230000006838 adverse reaction Effects 0.000 abstract 1
- 239000003589 local anesthetic agent Substances 0.000 abstract 1
- 210000004400 mucous membrane Anatomy 0.000 abstract 1
- 239000010408 film Substances 0.000 description 24
- 238000000034 method Methods 0.000 description 20
- 238000005303 weighing Methods 0.000 description 11
- 238000007605 air drying Methods 0.000 description 10
- 238000000465 moulding Methods 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 238000002156 mixing Methods 0.000 description 9
- 230000008569 process Effects 0.000 description 9
- 206010000210 abortion Diseases 0.000 description 7
- 231100000176 abortion Toxicity 0.000 description 7
- 230000036592 analgesia Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 239000010409 thin film Substances 0.000 description 4
- 210000004291 uterus Anatomy 0.000 description 4
- 206010002091 Anaesthesia Diseases 0.000 description 3
- 230000037005 anaesthesia Effects 0.000 description 3
- 229940035676 analgesics Drugs 0.000 description 3
- 239000000730 antalgic agent Substances 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 230000000916 dilatatory effect Effects 0.000 description 3
- 230000005284 excitation Effects 0.000 description 3
- 238000002690 local anesthesia Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 2
- 208000007502 anemia Diseases 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 230000007480 spreading Effects 0.000 description 2
- 238000003892 spreading Methods 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 230000001515 vagal effect Effects 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- 206010011409 Cross infection Diseases 0.000 description 1
- 235000009161 Espostoa lanata Nutrition 0.000 description 1
- 240000001624 Espostoa lanata Species 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- 206010071229 Procedural haemorrhage Diseases 0.000 description 1
- 208000036029 Uterine contractions during pregnancy Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
- 229960004373 acetylcholine Drugs 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 230000036471 bradycardia Effects 0.000 description 1
- 208000006218 bradycardia Diseases 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
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- 210000005036 nerve Anatomy 0.000 description 1
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- 230000035515 penetration Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 210000001186 vagus nerve Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides a disposable cervical dilator attached with a medicine film, and a preparation method of the disposable cervical dilator with the medicine film. The cervical dilator is attached with the medicine film of local anesthetics; when the disposable cervical dilator is used, the medicine film is swollen and dissolved under body temperature; and medicines in the medicine film are released out, and are absorbed by a cervical mucous membrane, so that pain of patients is relieved, and occurrences of adverse reactions are reduced. The disposable cervical dilator with the medicine film is convenient to use, and simple and feasible in preparation process; the related pharmaceutic adjuvants are all easy to purchase and are low in cost; and the disposable cervical dilator has good social and economic benefits.
Description
Technical field
The present invention relates to the medical apparatus and instruments that cervix dilating that a kind of department of obstetrics and gynecology often use is clinically used, be specifically related to a kind of one-off cervix dilator with the medicine film.
Background technology
Usually need to carry out cervical dilatation during intrauterine surgical, with inspection and the treatment that makes things convenient for the doctor.Cervical dilator is widely used in the department of obstetrics and gynecology clinical operation at present, such as artificial abortion, hysteroscopy, placement and taking-up intrauterine device, diagnostic curettage etc.
Existing cervical dilatation is a lot of with the apparatus kind, and commonly used is one-off cervix dilator clinically, is comprised of one group of diameter dilator bar from fine to coarse, its diameter of section is constant, during use, because the special physiological function that cervical orifice shrinks, must be begun by the thinner dilator bar of diameter, constantly change until reach till the requirement, its deficiency is, repeatedly inserts dilator bar, the patient suffering is larger, easily produce the feared state of mind, and operation is more loaded down with trivial details, also causes easily cross infection.Use in addition the gelatin rod, the gelatin rod needed 24 hours just can reach required cervix uteri mouth width, and operating time is long, patient's easy infection.
Chinese patent ZL201020124138.X discloses a kind of replacement-free dilating bar in addition, during use, the barred body front end is inserted in the cervix uteri mouth, then slowly swivel bolt, promote expansion gear and progressively advance, the barred body of cervix uteri port part is expanded gradually, the cervix uteri mouth is opened, after reaching requirement barred body is extracted out, avoided repeatedly changing the injury that dilator bar causes patient body.
Chinese patent ZL200620009381.0 discloses a kind of swelling formula palace neck spreader, formed by conduit, thin film air bag, inflation/deflation air bag, sebific duct, around the catheter proximal end outer wall, be fixed wtih the thin film air bag, be provided with a plurality of air-filled pores that communicate with thin film air bag inner chamber at the catheter proximal end tube wall, inflation/deflation air bag is connected on the rear end of conduit by the glue pipe socket load.By inflation, make the chap of thin film air bag external diameter, cervical orifice is also extended.
Chinese patent ZL200820017137.8 a kind of expansion type Uterus expanding stick for drug injection of openly knowing clearly, record first in use the length of cervix uteri, by push rod the barred body in the trocar sheath is pushed in the cervix uteri mouth, with being about to infusion of medicine in the hollow ram afterbody plastic bottle body at barred body, remove trocar sheath and push rod, barred body is met the liquid that contains analgesic drug product and slowly can be expanded, and the analgesic drug product in the barred body also can discharge and absorb by mucosa, play analgesia and expand the effect in palace, and the patient can not agonize.The undeclared barred body material of this patent, the barred body speed of expansion is indefinite when chance contains the liquid of analgesic drug product, and expanding the palace time may be longer.
Chinese patent ZL201020632911.3 discloses a kind of cervical dilator with the anesthetis storage chamber, comprise main body, rotating adjustment ring, tensioner ring, be provided with the anesthetis storage chamber in the inside of main body, regulate the flexible of tensioner ring by rotating adjustment ring, promote simultaneously the push rod in the anesthesia storage chamber, discharge anesthetis.
Although above-mentioned with mechanical system and airing form expansion cervix uteri mouth, easy and simple to handle, alleviated doctor's workload, this mode is difficult to the size of suitable control cervical dilatation apparatus, can cause patient's pain, and the expansion palace time is longer.
Without the conceived women of plan, fear operation owing to worrying pain, many women are subjected to pregnant women to wish to adopt painless surgical operation especially for the first time, and the syndromic generation of the pain in the artificial abortion and artificial abortion, because the expansion official, cervix uteri and uterus are subject to mechanical irritation and cause vagal excitation when inhaling the palace, discharge a large amount of acetylcholine, due to cardiovascular effect.Bradycardia, cardiac arrhythmia, blood pressure drops, pale complexion, perspiration, dizziness, uncomfortable in chest occur, even faint and twitch.These and anemia of pregnant woman's psychentonia, can not tolerate cervical dilatation, tractive and cross high negative pressure direct relation is arranged.
In order to alleviate the patient suffering, generally in cervix dilating, need to carry out local anesthesia to the patient clinically, the doctor often injects lignocaine, has increased medical expense and operation easier.Carry out local anesthesia after also having the doctor to infiltrate lignocaine with medical cotton ball, but the method dosage is inaccurate, and the risk of certain generation untoward reaction is arranged.
Lignocaine belongs to acyl Ammonia local anaesthetics, have rapid-action, penetrance is strong, disperse is wide, to the characteristics such as anemia of pregnant woman's main organs function is harmless, the generation of the other nerve block anesthesia cervix uteri capable of blocking of temporary dwelling palace neck and the impulsion of palace somesthesia teleneuron and spreading out of, and minimizing vagal excitation, alleviate because tractive and expansion are played analgesia and reduced the syndromic generation of artificial abortion the stimulation of uterus and cervix uteri, reduce intraoperative hemorrhage, shorten operating time, simple to operate, safety, do not affect again uterine contraction, and make the operation receiveing person at Consciousness and undergo surgery under the local painless situation.
Should be noted when using lignocaine that injection pumpback depletion of blood can inject, namely can not annotate people's vein, in order to avoid central nervous system and cardiovascular system are exerted an influence, emphasize that simultaneously local anaesthetics is to eliminate than mode by weighing in blood, its half-life and original blood drug level are irrelevant, increase drug level or increase equal extra-inning anaesthetic time of keeping in proportion of dose.
When carrying out Therapeutic Abortion, use the analgesia, it is painful to reduce the operation receiveing person, is the problem that current doctors should pay attention to, but there not being condition to carry out basic hospital and the community sanitary institute of general anesthesia painless surgical operation, but has been subject to very large puzzlement.In order to alleviate patient's misery, the capable paracervical block anesthesia of 2% lignocaine is used in the generation of prevention artificial abortion combined reaction, is basic hospital artificial abortion analgesia commonly used, satisfactory effect.
Summary of the invention
The present invention relates to a kind of one-off cervix dilator with lignocaine medicine film, the lignocaine medicine film that will contain effective dosage is attached on the suitable one-off cervix dilator, and medicine film swelling under body temperature is melted and the release medicine during use.The lignocaine produce effects is fast, and tissue penetration is good, and action time is short, can block the conduction of various neural impulses.The generation of cervical canal local anesthesia cervix uteri capable of blocking and palace somesthesia teleneuron impulsion and spreading out of, and minimizing vagus nerve, the conduction of impulse of excitation, thereby alleviate because tractive and the expansion to uterus and Cervical stimulation, play analgesic activity, and lax uterine smooth muscle makes cervical dilatation.
The purpose of this invention is to provide a kind of cervical dilator with the medicine film, solved when being cervical dilatation in the prior art because repeatedly inserting cervical dilator, the problem that the patient suffering is larger is characterized in that described cervical dilator comprises one-off cervix dilator and lignocaine medicine film.One-off cervix dilator of the present invention is the 5-7 cervical dilator, contain lidocaine hydrochloride and the applicable pharmaceutic adjuvant of pharmacy of effective dose in the described lignocaine medicine film, the consumption of lidocaine hydrochloride is 4mg～40mg/ in the described lignocaine medicine film.
Another object of the present invention is exactly to contain water-soluble high-molecular material in the medicine film, this water-soluble high-molecular material is met water and can be dissolved rapidly, form the good film of one deck lubricity on surface, cervical dilator tip, thereby make dilator can insert more smoothly the cervix uteri mouth, reduce to greatest extent patient's misery, and once get final product.
One-off cervix dilator with the medicine film of the present invention is characterized in that described local anaesthetics comprises lignocaine, chloroprocaine, procaine, bupivacaine, levobupivacaine, tetracaine, ropivacaine and salt thereof.
Described one-off cervix dilator with the medicine film of the present invention is characterized in that described local anaesthetics is lignocaine or its hydrochlorate.
Described one-off cervix dilator with the medicine film of the present invention is characterized in that the consumption of lidocaine hydrochloride in the described lignocaine medicine film is 4mg～40mg.
Described one-off cervix dilator with the medicine film of the present invention, it is characterized in that described water-soluble high-molecular compound comprises sodium alginate, sodium carboxymethyl cellulose, a kind of or its mixture in methylcellulose, hydroxypropyl cellulose, CP, Polyethylene Glycol and polyoxyethylene stearate (40) ester.
Polyethylene Glycol has another name called polymer, the polyethylene glycol oxide (PEO-LS) of α-hydrogen-ω-hydroxyl (oxygen-1,2-second two bases).Mean molecule quantity in the general name of about 200 at least 6000 ethylene glycol high polymer.
Described one-off cervix dilator with the medicine film of the present invention is characterized in that described water-soluble high-molecular compound consumption is 30%～80% of medicine film weight.
Described one-off cervix dilator with the medicine film of the present invention is characterized in that contained PEG-4000 in the described medicine film, polyoxyethylene stearate (40) ester.
One-off cervix dilator with lignocaine medicine film of the present invention is characterized in that preparation process comprises the steps:
After taking by weighing polymer substance in the prescription, lidocaine hydrochloride and being dissolved in water, add PEG-4000, the mixing of polyoxyethylene stearate (40) ester, after 40 ℃-50 ℃ of water-baths are stirred 10 minutes, use picks technique, cervical dilator is stained with is inserted into about 5cm height in the mentioned solution, take out the cold air drying molding.
One-off cervix dilator with lignocaine medicine film of the present invention in use, medicine film on the cervical dilator is the swelling dissolving under body temperature, drug release in the medicine film out, and absorb by mucosa, the effect of play analgesia, expanding the palace, simple to operation, alleviate patient's misery, alleviate medical and nursing work personnel workload, reduce the operation cost.And preparation technology is simple and easy to do, related pharmaceutic adjuvant all be easy to buy and cost lower, have good Social benefit and economic benefit.
The specific embodiment
The present invention will be further described below in conjunction with embodiment, but the present invention is not limited to these embodiment.
Embodiment 1
Specific operation process: after taking by weighing PEG-4000,60 ℃ of meltings of polyoxyethylene stearate (40) ester water-bath, add the lidocaine hydrochloride insulated and stirred after 10 minutes, use picks technique, cervical dilator is inserted into about 5cm height in the upper solution, takes out the cold air drying molding, the skim of smooth in appearance, toughness is bad, more crisp, uniformity is not so good, is limited to when dissolving about 3 minutes.
Embodiment 2
Specific operation process: after taking by weighing sodium alginate, lidocaine hydrochloride and being dissolved in water, add PEG-4000, the mixing of polyoxyethylene stearate (40) ester, after 40 ℃ of water-baths are stirred 10 minutes, use picks technique, cervical dilator is stained with is inserted into about 5cm height in the upper solution, take out the cold air drying molding, smooth in appearance, good toughness was limited to when dissolving about 1 minute.
Embodiment 3
Specific operation process: after taking by weighing sodium alginate, lidocaine hydrochloride and being dissolved in water, add again PEG-4000, S-40 water-bath in 40 ℃ of mixing, after the insulated and stirred 10 minutes, use picks technique, cervical dilator is stained with is inserted into about 5cm height in the upper solution, take out the cold air drying molding, smooth in appearance, good toughness was limited to when dissolving about 1 minute.
Embodiment 4:
Specific operation process: after taking by weighing sodium alginate, lidocaine hydrochloride and being dissolved in water, add PEG-4000, the mixing of polyoxyethylene stearate (40) ester, after 40 ℃ of water-baths are stirred 10 minutes, use picks technique, cervical dilator is stained with is inserted into about 5cm height in the upper solution, take out the cold air drying molding, smooth in appearance, good toughness was limited to when dissolving about 1 minute.
Embodiment 5:
Specific operation process: after taking by weighing xanthan gum, lidocaine hydrochloride and being dissolved in water, add PEG-4000, the mixing of polyoxyethylene stearate (40) ester, after 40 ℃ of water-baths are stirred 10 minutes, use picks technique, cervical dilator is stained with is inserted into about 5cm height in the upper solution, take out the cold air drying molding, smooth in appearance, good toughness was limited to when dissolving about 1 minute.
Embodiment 6:
Specific operation process: after taking by weighing PVP, lidocaine hydrochloride and being dissolved in water, add PEG-4000, the mixing of polyoxyethylene stearate (40) ester, after 40 ℃ of water-baths are stirred 10 minutes, use picks technique, cervical dilator is stained with is inserted into about 5cm height in the upper solution, take out the cold air drying molding, smooth in appearance, good toughness was limited to when dissolving about 1 minute.Embodiment 7:
Specific operation process: after taking by weighing methylcellulose, lidocaine hydrochloride and being dissolved in water, add PEG-4000, the mixing of polyoxyethylene stearate (40) ester, after 40 ℃ of water-baths are stirred 10 minutes, use picks technique, cervical dilator is stained with is inserted into about 5cm height in the upper solution, take out the cold air drying molding, smooth in appearance, good toughness was limited to when dissolving about 1 minute.
Embodiment 8:
Specific operation process: after taking by weighing crosslinked acrylic resin, lidocaine hydrochloride and being dissolved in water, add PEG-4000, the mixing of polyoxyethylene stearate (40) ester, after 40 ℃ of water-baths are stirred 10 minutes, use picks technique, cervical dilator is stained with is inserted into about 5cm height in the upper solution, take out the cold air drying molding, smooth in appearance, good toughness was limited to when dissolving about 1 minute.
Embodiment 9:
Specific operation process: after taking by weighing sodium carboxymethyl cellulose, lidocaine hydrochloride and being dissolved in water, add PEG-4000, the mixing of polyoxyethylene stearate (40) ester, after 40 ℃ of water-baths are stirred 10 minutes, use picks technique, cervical dilator is stained with is inserted into about 5cm height in the upper solution, take out the cold air drying molding, smooth in appearance, good toughness was limited to when dissolving about 1 minute.
Claims (7)
1. the one-off cervix dilator with the medicine film is characterized in that described cervical dilator tip with the medicine film, and it contains the combination of at least a local anaesthetics and at least a water-soluble high-molecular compound.
2. the one-off cervix dilator with the medicine film according to claim 1 is characterized in that described local anaesthetics comprises lignocaine, chloroprocaine, procaine, bupivacaine, levobupivacaine, tetracaine, ropivacaine and salt thereof.
According to claim 1 with 2 described one-off cervix dilators with the medicine film, it is characterized in that described local anaesthetics is lignocaine or its hydrochlorate.
According to claim 1 with 3 described one-off cervix dilators with the medicine film, it is characterized in that the consumption of lidocaine hydrochloride in the described lignocaine medicine film is 4mg～40mg.
5. the one-off cervix dilator with the medicine film according to claim 1, it is characterized in that described water-soluble high-molecular compound comprises sodium alginate, sodium carboxymethyl cellulose, a kind of or its mixture in methylcellulose, hydroxypropyl cellulose, CP, Polyethylene Glycol and polyoxyethylene stearate (40) ester.
6. the one-off cervix dilator with the medicine film according to claim 1 is characterized in that described water-soluble high-molecular compound consumption is 30%～80% of medicine film weight.
7. the one-off cervix dilator with the medicine film according to claim 1 is characterized in that containing in the described medicine film PEG-4000, polyoxyethylene stearate (40) ester.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210532882.7A CN102974025B (en) | 2012-12-11 | 2012-12-11 | A kind of one-off cervix dilator with medicine film |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210532882.7A CN102974025B (en) | 2012-12-11 | 2012-12-11 | A kind of one-off cervix dilator with medicine film |
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| Publication Number | Publication Date |
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| CN102974025A true CN102974025A (en) | 2013-03-20 |
| CN102974025B CN102974025B (en) | 2015-09-30 |
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| CN201210532882.7A Expired - Fee Related CN102974025B (en) | 2012-12-11 | 2012-12-11 | A kind of one-off cervix dilator with medicine film |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104434885A (en) * | 2014-11-12 | 2015-03-25 | 天津大学 | Water-soluble polymeric membrane capable of quickly releasing drugs and preparation method thereof |
| CN107198814A (en) * | 2016-03-18 | 2017-09-26 | 天津和杰医疗器械有限公司 | Disposable pastille cervical dilator bar |
| CN112773317A (en) * | 2020-12-25 | 2021-05-11 | 深圳市人民医院 | Soft hysteroscope guiding device |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1091041A (en) * | 1993-12-04 | 1994-08-24 | 中国人民解放军优生优育研究中心 | Analgesic dilator for cervix and production technology thereof |
| CN1846703A (en) * | 2006-02-13 | 2006-10-18 | 程定超 | Vagina administration mifepristone prepn and its composition and prepn process |
| CN101116762A (en) * | 2006-07-31 | 2008-02-06 | 何东方 | Disposable active cervical dilator bar |
| CN101357121A (en) * | 2008-09-03 | 2009-02-04 | 宋信平 | Preparation of arilin slow-release medicine-membrane for tooth |
-
2012
- 2012-12-11 CN CN201210532882.7A patent/CN102974025B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1091041A (en) * | 1993-12-04 | 1994-08-24 | 中国人民解放军优生优育研究中心 | Analgesic dilator for cervix and production technology thereof |
| CN1846703A (en) * | 2006-02-13 | 2006-10-18 | 程定超 | Vagina administration mifepristone prepn and its composition and prepn process |
| CN101116762A (en) * | 2006-07-31 | 2008-02-06 | 何东方 | Disposable active cervical dilator bar |
| CN101357121A (en) * | 2008-09-03 | 2009-02-04 | 宋信平 | Preparation of arilin slow-release medicine-membrane for tooth |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104434885A (en) * | 2014-11-12 | 2015-03-25 | 天津大学 | Water-soluble polymeric membrane capable of quickly releasing drugs and preparation method thereof |
| CN107198814A (en) * | 2016-03-18 | 2017-09-26 | 天津和杰医疗器械有限公司 | Disposable pastille cervical dilator bar |
| CN112773317A (en) * | 2020-12-25 | 2021-05-11 | 深圳市人民医院 | Soft hysteroscope guiding device |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102974025B (en) | 2015-09-30 |
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