CN102973583B - Compound gentamicin sulphate composition for treating poultry diarrhea and preparation method thereof - Google Patents
Compound gentamicin sulphate composition for treating poultry diarrhea and preparation method thereof Download PDFInfo
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- CN102973583B CN102973583B CN201210516233.8A CN201210516233A CN102973583B CN 102973583 B CN102973583 B CN 102973583B CN 201210516233 A CN201210516233 A CN 201210516233A CN 102973583 B CN102973583 B CN 102973583B
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Abstract
The invention relates to a compound gentamicin sulphate composition for treating poultry diarrhea. The compound gentamicin sulphate composition is characterized by being prepared by mixing the following components by weight part: 5-10 parts of gentamicin sulphate, 10-15 parts of ciprofloxacin, 10-20 parts of berberine hydrochloride, 5-9 parts of trimethoprim Lactate salt and 46-70 parts of glucosum anhydricum. The compound gentamicin sulphate composition has the beneficial effects of reasonable formula, simple preparation, extremely obvious curative effect and special effect on the treatment of poultry diarrhea through clinical proving.
Description
Technical field
The compound gentamicine sulphate composition and method of making the same that the present invention relates to treat poultry diarrhoea, belongs to animal field of medicaments, particularly a kind of compound gentamicine sulphate composition and method of making the same that is specifically designed to treatment poultry diarrhoea.
Background technology
Poultry diarrhoea is mainly a kind of more serious disease being caused by pathogenic bacterias such as escherichia coli and Salmonellas.Long-term serious diarrhoea, can make poultry body lose large quantity of moisture, salt and alkaline matter, and dehydration, salt deficiency and acidosis in various degree occur, the blood contracting that thickens, thus affect the normal circulation of body fluid, finally cause heart failure and cause death.The less sickness rate of poultry age in days is higher, and case fatality rate is also higher, is generally between 10%-40%.Primary disease all can occur throughout the year, is one of principal disease of harm poultry farming.
This kind of disease almost spreads all over the world all poultry farmings country, is widely distributed.At present, treat the most frequently used antimicrobial product of this disease, because prescription is unreasonable, easily produce drug resistance, it is not fine causing clinical effectiveness.
Therefore researching and developing a kind of specific medicament for the treatment of the difficult generation drug resistance of poultry diarrhoea is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, a kind of reasonable recipe, simple, the difficult compound gentamicine sulphate composition and method of making the same that produces effective treatment poultry diarrhoea of drug resistance of preparation are provided.
Implementation of the present invention is as follows for achieving the above object: a kind of compound gentamicine sulphate compositions for the treatment of poultry diarrhoea, by following component by weight mixed preparing form: gentamycin sulfate 5-10 part, ciprofloxacin 10-15 part, berberine hydrochloride 10-20 part, lactic acid trimethoprim 5-9 part, anhydrous glucose 46-70 part.
Described various component optimum ratio amount is: 7.5 parts of gentamycin sulfate, 12.5 parts of ciprofloxacins, 15 parts of berberine hydrochloride, 7 parts of lactic acid trimethoprims, 58 parts of anhydrous glucose.
Treat a preparation method for the compound gentamicine sulphate compositions of poultry diarrhoea, carry out as follows:
(1) take by weight gentamycin sulfate 5-10 part, ciprofloxacin 10-15 part and anhydrous glucose 15-25 part, mix 5-10 minute to even;
(2) take by weight berberine hydrochloride 10-20 part, lactic acid trimethoprim 5-9 part, anhydrous glucose 15-29 part, mix 5-10 minute to even;
(3) merge the mixture and residue anhydrous glucose that above-mentioned (1), (2) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Gentamycin sulfate: white or off-white powder, easily molten in water, for aminoglycosides broad ectrum antibiotic, multiple gram-negative bacteria and positive bacteria are all had to antibacterial and bactericidal action, oral absorption is poor, is mainly used in clinically the responsive microbial intestinal infection such as escherichia coli, dysentery bacterium, Salmonella and bacillary dysentery etc.
Ciprofloxacin: light yellow crystalline powder, soluble in water, fluoroquinolone antibacterial agent, has broad-spectrum antibacterial action, and oral absorption is good.Be applicable to the responsive microbial respiratory system such as escherichia coli, Salmonella, urinary system and intestinal infection etc.This product and other antibiotic be without cross resistance, still responsive to this product to beta-lactam, aminoglycoside, sulfonamides Resistant strain.
Berberine hydrochloride: yellow acicular crystal, water-soluble, has a broad antifungal spectrum, all has and kill or inhibitory action multiple gram positive bacteria and negative bacterium.This product oral absorption is poor, clinical intestinal infection and the bacillary dysentery etc. of being mainly used in.This product and penicillin, streptomycin etc. are without cross resistance.
Lactic acid trimethoprim: white or off-white color crystalline powder, water-soluble, during with sulfa drugs and other antibacterial coupling, there is notable synergistic effect, can increase by ten effects to decades of times.Do not use separately, generally by the ratio of 1: 5, use, can treat fowl and raise bacillary dysentery that escherichia coli, Salmonella etc. cause, enteritis, respiratory tract infection etc., also can be used for the control of coccidiosis of domestic fowls.
All medicines are according to antimicrobial susceptibility experimental result compatible combination above, and the paathogenic factor for poultry diarrhoea, has good clinical effectiveness.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Cost is low, is difficult for producing drug resistance, curative effect highly significant.The present invention, according to antimicrobial susceptibility experimental result compatible combination, optimizes this three kinds of medicines, and they is formed according to optimum ratio, and clinical practice proves that treatment poultry diarrhoea is had to specially good effect.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of compound gentamicine sulphate composition and method of making the same for the treatment of poultry diarrhoea: carry out as follows: (every part by 10g)
(1) take by weight 100 parts of 50 parts of gentamycin sulfate, ciprofloxacin and 150 parts of anhydrous glucose, mixes 5-10 minute to even;
(2) take by weight 100 parts of berberine hydrochloride, 50 parts of lactic acid trimethoprims, 150 parts of anhydrous glucose, mix 5-10 minute to even;
(3) merge the mixture and residue anhydrous glucose that above-mentioned (1), (2) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of compound gentamicine sulphate composition and method of making the same for the treatment of poultry diarrhoea: carry out as follows: (every part by 10g)
(1) take by weight 125 parts of 75 parts of gentamycin sulfate, ciprofloxacin and 200 parts of anhydrous glucose, mixes 5-10 minute to even;
(2) take by weight 150 parts of berberine hydrochloride, 70 parts of lactic acid trimethoprims, 220 parts of anhydrous glucose, mix 5-10 minute to even;
(3) merge the mixture and residue anhydrous glucose that above-mentioned (1), (2) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of compound gentamicine sulphate composition and method of making the same for the treatment of poultry diarrhoea: carry out as follows: (every part by 10g)
(1) take by weight 150 parts of 100 parts of gentamycin sulfate, ciprofloxacin and 25 parts of anhydrous glucose, mixes 5-10 minute to even;
(2) take by weight 200 parts of berberine hydrochloride, 90 parts of lactic acid trimethoprims, 290 parts of anhydrous glucose, mix 5-10 minute to even;
(3) merge the mixture and residue anhydrous glucose that above-mentioned (1), (2) step make, continue to mix 10-15 minute to even.
Clinical trial:
Clinical experiment animal selects 15 ages in days, body weight between 0.5kg-0.7kg, the ill broiler that Laboratory Diagnosed is salmonellosis of chicken.Ill chicken isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 30 every group, 3 groups of feeding environments are identical, and experimental period is carried out 5 days altogether; Blank group is left intact, and medicine matched group is used treatment with " dysentery is clear " by specification; Present composition group is by the ill poultry of product feeding of the present invention etc., and a day dose is: by the every 100g of the present invention 300kg that drinks water, every day 2-3 time, be used in conjunction 3-5 day; After oral, by gastrointestinal absorption, reach the object for the treatment of disease.Result (testing the 5th day) when following table is experiment end.
Table is the field applicable cases contrast of the present invention and other medicines treatment salmonellosis of chicken:
| Numbering | Group | Mortality rate % | Cure rate % | During end, there is symptom rate % |
| I | Blank group | 13.3 | 53.4 | 33.3 |
| II | Clear group of dysentery | 6.7 | 76.4 | 16.7 |
| III | Present composition group | 3.3 | 90.0 | 6.7 |
This clinical effectiveness statistical analysis, present composition group is being compared difference extremely significantly (P < 0.01) with " dysentery is clear " group aspect cure rate.
Above-mentioned detailed description of the compound gentamicine sulphate composition and method of making the same of this treatment poultry diarrhoea being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (2)
1. treat the compound gentamicine sulphate compositions that poultry is suffered from diarrhoea for one kind, it is characterized in that by following component by weight mixed preparing form: gentamycin sulfate 5-10 part, ciprofloxacin 10-15 part, berberine hydrochloride 10-20 part, lactic acid trimethoprim 5-9 part, anhydrous glucose 46-70 part
Concrete preparation method is as follows:
(1) take by weight gentamycin sulfate 5-10 part, ciprofloxacin 10-15 part and anhydrous glucose 15-25 part, mix 5-10 minute to even;
(2) take by weight berberine hydrochloride 10-20 part, lactic acid trimethoprim 5-9 part, anhydrous glucose 15-29 part, mix 5-10 minute to even;
(3) merge the mixture and residue anhydrous glucose that above-mentioned (1), (2) step make, continue to mix 10-15 minute to even.
2. the compound gentamicine sulphate compositions for the treatment of according to claim 1 poultry diarrhoea, it is characterized in that by following component by weight mixed preparing form: 7.5 parts of gentamycin sulfate, 12.5 parts of ciprofloxacins, 15 parts of berberine hydrochloride, 7 parts of lactic acid trimethoprims, 58 parts of anhydrous glucose.
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| CN201210516233.8A CN102973583B (en) | 2012-11-22 | 2012-11-22 | Compound gentamicin sulphate composition for treating poultry diarrhea and preparation method thereof |
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| CN201210516233.8A CN102973583B (en) | 2012-11-22 | 2012-11-22 | Compound gentamicin sulphate composition for treating poultry diarrhea and preparation method thereof |
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| CN102973583A CN102973583A (en) | 2013-03-20 |
| CN102973583B true CN102973583B (en) | 2014-11-12 |
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| CN109331034A (en) * | 2018-12-20 | 2019-02-15 | 江苏卓和药业有限公司 | A kind of pharmaceutical composition for treating diarrhea |
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| KR100423895B1 (en) * | 2001-02-19 | 2004-03-24 | 주식회사 엘지생명과학 | Compositions of suspensions of ceftiofur hydrochloride |
| CN101467999A (en) * | 2007-12-25 | 2009-07-01 | 郑州后羿制药有限公司 | Compound preparation of berberine hydrochloride |
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