CN102973241A - Laser diffracted ray scanning confocal ophthalmoscope system based on adaptive optics - Google Patents
Laser diffracted ray scanning confocal ophthalmoscope system based on adaptive optics Download PDFInfo
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- CN102973241A CN102973241A CN2012105239664A CN201210523966A CN102973241A CN 102973241 A CN102973241 A CN 102973241A CN 2012105239664 A CN2012105239664 A CN 2012105239664A CN 201210523966 A CN201210523966 A CN 201210523966A CN 102973241 A CN102973241 A CN 102973241A
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Abstract
The invention discloses a laser diffracted ray scanning confocal ophthalmoscope system based on the adaptive optics. The laser diffracted ray scanning confocal ophthalmoscope system based on the adaptive optics comprises a linear light beam generation module, a light splitting module, a scanning module, an imaging module, an output module and a wavefront detection and correction module. A light beam emitted from a beacon is subjected to collimation and beam expansion by a collimating lens into parallel light beams; after successively passing through a beam splitter, a first beam contraction and expansion element group, a wavefront corrector and a second beam contraction and expansion element group, the light beam is emitted from the wavefront detection and correction module and is then transmitted into human eyes via the scanning module so as to be gathered into one point on the retina; entering light is reflected by the retina of the human eye, and human eye aberration information is carried; the entering light is returned along the original route and is subjected to deflection reflection by the light splitting module; the entering light enters a wavefront detector via a third beam contraction and expansion element group after being reflected by the beam splitter; the received human eye aberration information is transferred to a wavefront processor by the wavefront detector; the wavefront processor generates control voltage used for controlling the wavefront corrector; the control voltage is transferred to the wavefront corrector to correct the human eye aberration in real time; and the resolution and the contrast ratio of an image are increased.
Description
Technical field
The present invention is a kind of confocal ophthalmoscope of laser diffraction line sweep system based on adaptive optics, relates to self adaptation Wavefront detecting and alignment technique field, belongs to human eye retina's imaging armarium manufacturing technology field.
Background technology
Among Chinese patent " the confocal ophthalmoscope system and method for a kind of line sweep based on laser diffraction " the grant number ZL201010595587.7, introduce the confocal ophthalmoscope of a kind of line sweep based on laser diffraction system, comprised Line beam generation module, spectral module, scan module, image-forming module and output module.This system utilizes grating and cylindrical lens that collimated light beam is transformed to Line beam, so that the Line beam light intensity that generates is the even distribution of non-Gaussian, adopt a slice scanning galvanometer that Line beam is carried out one-dimensional space scanning illumination optical fundus retina, use simultaneously the non-scanning line light beam imaging of line detector to returning from the optical fundus retinal reflex, system only uses a scanning galvanometer and a line detector, and the movable part number is few; Simultaneously, confocal slit and optical fundus retinal plane conjugation have been got rid of non-retinal plane veiling glare to the impact of image quality, have realized the high-resolution of confocal imaging principle.The present invention has that ray beam quality is good, system structure is simple, it is easy to make, light path is shortly suitablely regulated, the advantage of small and exquisite applicable, good stability and high imaging frame frequency.But, human eye itself as optics of ophthalmoscope system important component part is not a perfect optical system, it brings various aberrations to imaging system, seriously be lowered into image quality, so that the image resolution ratio that real system obtains is often lower, thereby be difficult to observe the amphiblestroid fine structure of living human eye.
Adaptive optical technique is just to begin the new optical technique that grows up the external seventies, it is by the dynamic wavefront error of real-time detection-control-correcting optical system, thereby make optical system have the ability that automatic adaptation change of external conditions remains optimum Working, can proofread and correct dynamic aberration in real time, thereby greatly improve imaging resolution.Adaptive optical technique is applied to eyes imaging, can correction time and the space on living human eye dynamic aberrations of change at random all, thereby can realize the amphiblestroid high resolution imaging of living human eye.
Summary of the invention
The objective of the invention is to overcome the deficiency of above-mentioned prior art, improving the confocal ophthalmoscope of laser diffraction line sweep system is subjected to the human eye dynamic aberration to affect the lack of resolution that causes, by adding adaptive optical technique human eyes wave-front optical aberration is carried out real-time detection and correction, thereby improve the optical fundus retinal images quality of the confocal ophthalmoscope of line sweep system.
A kind of confocal ophthalmoscope of laser diffraction line sweep system based on adaptive optics of the present invention, mainly comprise Line beam generation module, spectral module, scan module, image-forming module, output module and Wavefront detecting and correction module, it is characterized in that: Wavefront detecting and correction module comprise beacon, collimating lens, beam splitter, wave front detector, wave-front corrector, wave front processor and a series of contracting bundle beam-expanding element group.It is collimated light beam through the collimating lens collimator and extender that described beacon sends light beam, pass through successively beam splitter, contracting bundle beam-expanding element group one, wave-front corrector, contracting bundle beam-expanding element group two is rear from Wavefront detecting and correction module outgoing, then spread into human eye through scan module, and pool a point at retina, after the light that enters is reflected by the human eye retina, carrier's aberration information, return along former road, by the spectral module deflecting reflection, after the beam splitter reflection, enter wave front detector through contracting bundle beam-expanding element group three, wave front detector passes to wave front processor with the human eye aberration information that receives, and wave front processor produces the control voltage of control wave-front corrector, and will control voltage and pass to wave-front corrector, proofread and correct in real time human eye aberration, increase resolution and the contrast of image.
Described beacon can be LASER Light Source or light emitting diode or super-radiance light emitting diode.
Described Wavefront sensor can be grating shearing interference wave front sensor, Hartmann wave front sensor, wavefront curvature sensor, heterodyne point-diffraction interference sensor or rectangular pyramid Wavefront sensor.
Described wave-front corrector can be the discrete Piezoelectric Driving distorting lens of continuous surface, discrete surface Piezoelectric Driving distorting lens, microelectromechanical systems discrete surface distorting lens, membrane deformable mirror, bimorph deformable mirror or LCD space light modulator.
Described wave front processor can be analog control circuit or digital computer.
The transmission-type contracting bundle beam-expanding system that described contracting bundle beam-expanding element group can be comprised of two lens, or the reflective contracting bundle beam-expanding system that is formed by the two sides spherical reflector.
Described beam splitter can be dichroic beam splitting plain film or dichroic beam splitter prism.
The present invention compared with prior art has following advantage:
Adaptive optical technique is introduced in the confocal ophthalmoscope of laser diffraction line sweep, the dynamic wave front aberration of wave front detector real-time detection human eye, wave front aberration control wave-front corrector after wave front processor is processed carries out real time correction to the incident wavefront with wave front aberration, so that the wavefront that line detector is surveyed is not for containing the wavefront of human eye aberration, thereby obtain than the confocal ophthalmoscope of laser diffraction line sweep of the aberrationless calibration capability retinal images of high-resolution and contrast more.
Description of drawings
Fig. 1 is the confocal ophthalmoscope system construction drawing of a kind of laser diffraction line sweep based on adaptive optics of the present invention;
Fig. 2 is the light path sketch map of a kind of confocal ophthalmoscope of laser diffraction line sweep system based on adaptive optics of the present invention;
Fig. 3 is that the wave front aberration of a kind of confocal ophthalmoscope of laser diffraction line sweep system based on adaptive optics of the present invention is surveyed and correcting process figure.
Specific embodiments
Introduce in detail the present invention below in conjunction with the drawings and the specific embodiments.
As shown in Figure 1, for the confocal ophthalmoscope system construction drawing of a kind of laser diffraction line sweep based on adaptive optics of the present invention, mainly comprise Line beam generation module 1, spectral module 2, scan module 3, image-forming module 5, output module 6 and Wavefront detecting and correction module 7.
Wavefront detecting and correction module 7 comprise beacon 700, collimating lens 710, beam splitter 720-1 and 720-2, contracting bundle beam-expanding element group 1, wave-front corrector 740, plane mirror 750, contracting bundle beam-expanding element group 2 760, contracting bundle beam-expanding element group 3 770, wave front detector 780 and wave front processor 790.The light beam that beacon 700 sends is used for wave front aberration and surveys, the light beam that beacon 700 sends is transformed to collimated light beam behind collimating lens 710 collimations, collimated light beam is propagated by spectral module 2 direct transmissions through beam splitter 720-1 reflection, successively through contracting bundle beam-expanding element group 1, wave-front corrector 740, plane mirror 750, the 2 760 rear outgoing of contracting bundle beam-expanding element group, then spread into human eye 4 through scan module 3, and pool a point at retina, the light that enters by human eye 4 retinal reflexs after, carrier's aberration information, return along former road, by spectral module 2 deflecting reflections, after beam splitter 720-2 reflection, enter wavefront detector 780 through reducing and expansion bundle element group 3 770 is laggard, wave front detector 780 passes to wave front processor 790 with the human eye aberration information that receives, wave front processor 790 produces the control voltage of control wave-front corrector, and will control voltage and pass to wave-front corrector 740.
Figure 2 shows that the light path sketch map of a kind of confocal ophthalmoscope of laser diffraction line sweep system based on adaptive optics of the present invention.Dotted line is depicted as system's primary optical axis, and all elements are all arranged along primary optical axis, and clear aperture is contour with one heart, and light beam is all propagated along system's primary optical axis, is illustrative nature among the figure, does not represent real optical design parameter.
Beacon is LASER Light Source or light emitting diode or super-radiance light emitting diode, and what adopt in the present embodiment is LASER Light Source, and wavelength is the near infrared light of 680nm.
Collimating lens is single convex lens or is cemented doublet that present embodiment adopts the single convex lens that focal length is 20mm.
Beam splitter is dichroic beam splitting plain film or dichroic beam splitter prism, adopts dichroic beam splitting plain film in the present embodiment.
Contracting bundle beam-expanding element group is the transmission-type contracting bundle beam-expanding system that is comprised of two lens, or the reflective contracting bundle beam-expanding system that is formed by the two sides spherical reflector, adopt the transmission-type contracting bundle beam-expanding system that is formed by two lens in the present embodiment, contracting bundle beam-expanding element group is used for changing beam size, makes it to mate with the optical element aperture.
Wavefront sensor is grating shearing interference wave front sensor or Hartmann wave front sensor or wavefront curvature sensor or heterodyne point-diffraction interference sensor or rectangular pyramid Wavefront sensor, adopts Hartmann wave front sensor in the present embodiment.
Wave-front corrector is the discrete Piezoelectric Driving distorting lens of continuous surface or discrete surface Piezoelectric Driving distorting lens or microelectromechanical systems discrete surface distorting lens or membrane deformable mirror or bimorph deformable mirror or LCD space light modulator, adopts microelectromechanical systems discrete surface distorting lens in the present embodiment.
Wave front processor can be analog control circuit or digital computer, adopts digital computer in the present embodiment.
As shown in Figure 3, survey and correcting process figure for the wave front aberration of a kind of confocal ophthalmoscope of laser diffraction line sweep system based on adaptive optics of the present invention.The scattered light of carrier's wavefront aberration information returns along original optical path and arrives wave front detector 780, the signal that comprises human eyes wave-front optical aberration information that wave front detector 780 will detect passes to wave front processor 790, calculate human eyes wave-front optical aberration through wave front restoration, calculate the required control signal of compensated wave front-distortion by control algolithm again, again control signal is exported to respectively wave-front corrector 740, can the real time correction human eye aberration.
The present invention does not limit to and above-mentioned example, and persons skilled in the art can adopt numerous embodiments to realize the present invention according to content disclosed by the invention.
Claims (7)
1. the confocal ophthalmoscope of the laser diffraction line sweep system based on adaptive optics is characterized in that comprising: Line beam generation module, spectral module, scan module, image-forming module, output module and Wavefront detecting and correction module; Described Wavefront detecting and correction module comprise beacon, collimating lens, beam splitter, wave front detector, wave-front corrector, wave front processor and three groups of contracting bundle beam-expanding element groups; It is collimated light beam through the collimating lens collimator and extender that described beacon sends light beam, pass through successively beam splitter, contracting bundle beam-expanding element group one, wave-front corrector, contracting bundle beam-expanding element group two is rear from Wavefront detecting and correction module outgoing, then spread into human eye through scan module, and pool a point at retina, after the light that enters is reflected by the human eye retina, carrier's aberration information, return along former road, by the spectral module deflecting reflection, after the beam splitter reflection, enter wave front detector through contracting bundle beam-expanding element group three, wave front detector passes to wave front processor with the human eye aberration information that receives, and wave front processor produces the control voltage of control wave-front corrector, and will control voltage and pass to wave-front corrector, proofread and correct in real time human eye aberration, increase resolution and the contrast of image.
2. the described confocal ophthalmoscope of laser diffraction line sweep system based on adaptive optics according to claim 1, it is characterized in that: described beacon is LASER Light Source or light emitting diode or super-radiance light emitting diode.
3. the described confocal ophthalmoscope of laser diffraction line sweep system based on adaptive optics according to claim 1, it is characterized in that: described Wavefront sensor is grating shearing interference wave front sensor, Hartmann wave front sensor, wavefront curvature sensor, heterodyne point-diffraction interference sensor or rectangular pyramid Wavefront sensor.
4. the described confocal ophthalmoscope of laser diffraction line sweep system based on adaptive optics according to claim 1, it is characterized in that: described wave-front corrector is the discrete Piezoelectric Driving distorting lens of continuous surface, discrete surface Piezoelectric Driving distorting lens, microelectromechanical systems discrete surface distorting lens, membrane deformable mirror, bimorph deformable mirror or LCD space light modulator.
5. the described confocal ophthalmoscope of laser diffraction line sweep system based on adaptive optics according to claim 1, it is characterized in that: described wave front processor is analog control circuit or digital computer.
6. the described confocal ophthalmoscope of laser diffraction line sweep system based on adaptive optics according to claim 1, it is characterized in that: described every group of contracting bundle beam-expanding element group restrainted beam-expanding system by the transmission-type contracting that two lens form, or the reflective contracting bundle beam-expanding system that is comprised of the two sides spherical reflector.
7. the described confocal ophthalmoscope of laser diffraction line sweep system based on adaptive optics according to claim 1, it is characterized in that: described beam splitter is dichroic beam splitting plain film or dichroic beam splitter prism.
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| CN104127169A (en) * | 2014-08-11 | 2014-11-05 | 中国科学院光电技术研究所 | Device for testing contrast response function (CRF) based on human eye aberration correction |
| CN106338818A (en) * | 2015-07-07 | 2017-01-18 | 中国科学院理化技术研究所 | Microsecond pulsed sodium beacon-based adaptive optical tomography correction device |
| WO2018228354A1 (en) * | 2017-06-16 | 2018-12-20 | 成都安的光电科技有限公司 | Parfocal control system for emitted laser and target detection light |
| CN111928960A (en) * | 2020-08-19 | 2020-11-13 | 深圳元戎启行科技有限公司 | Wavefront detection device and imaging system based on wavefront detection |
| CN114748034A (en) * | 2022-05-05 | 2022-07-15 | 中国科学院光电技术研究所 | Self-adaptive confocal ophthalmoscope based on multiple scattered light imaging |
| CN115553711A (en) * | 2022-10-14 | 2023-01-03 | 中国科学院苏州生物医学工程技术研究所 | Self-adaptive optics and wavefront detection system based on mask modulation |
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| CN114748034A (en) * | 2022-05-05 | 2022-07-15 | 中国科学院光电技术研究所 | Self-adaptive confocal ophthalmoscope based on multiple scattered light imaging |
| CN114748034B (en) * | 2022-05-05 | 2023-09-19 | 中国科学院光电技术研究所 | Self-adaptive confocal ophthalmoscope based on multiple scattered light imaging |
| CN115553711A (en) * | 2022-10-14 | 2023-01-03 | 中国科学院苏州生物医学工程技术研究所 | Self-adaptive optics and wavefront detection system based on mask modulation |
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