CN102949571B - Medicine for treating chronic osteomyelitis - Google Patents

Abstract

The invention discloses a medicine for treating the chronic osteomyelitis, belonging to the field of traditional Chinese medicines. The medicine comprises the effective components in parts by weight: 40-45 parts of asparagus cochinchinensis, 40-60 parts of rehmanniae vaporata, 40-55 parts of rhizoma anemarrhenae, 40-55 parts of small purple flowersherba violae, 40-50 parts of parasitic loranthus, 40-50 parts of dry radix puerariae, 35-55 parts of rhizoma atractylodis, 35-50 parts of barbary wolfberry fruit, 30-50 parts of pawpaw, 25-45 parts of myrrh, 25-45 parts of golden cypress, 25-45 parts of divaricate saposhnikovia root, 25-40 parts of radix angelicae, 20-40 parts of cuttle bone, 15-35 parts of lumbricus, 15-35 parts of scutellaria baicalensis, 15-30 parts of endothelium corneum gigeriae galli, 10-15 parts of borneol, 5-10 parts of cortex cinnamomi and 5-10 parts of corn cervi pantotrichum. The medicine disclosed by the invention has the advantages that traditional Chinese medicines are adopted, the compatibility of material selection is excellent, all the components dependences are prepared according to the properties, the function of treating both principal and secondary aspectmanifestation and root cause of disease is achieved, and the effects of improving the blood circulation, regulating vital energy, dispersing blood stasis and toxicity; the absorbing effect is good, the treating effect is obvious, the safe and reliable effects are achieved, no toxic and side effects and clinical adverse reaction are caused; and by clinical verification, the treating effect for chronic osteomyelitis is excellent.

Description

A kind of medicine for the treatment of chronic osteomyelitis

Affiliated technical field

The present invention relates to the field of Chinese medicines, relate in particular to a kind of medicine for the treatment of chronic osteomyelitis.

Background technology

Osteomyelitis is a kind of infection and destruction of bone, by aerobic or anaerobe, mycobacteria, fungus, is caused.The penetrance bone injury position that osteomyelitis is apt to occur in the foot of vertebra, diabetics or causes due to wound or operation, the common site of child is that blood is for good long bone, as the metaphysis of tibia or femur.

The traditional Chinese medical science is referred to as pyogenic infection of the bone, and its origin cause of formation is commonly considered as " traumatic injury, qi depression to blood stasis infect poison evil, and the ecchymosis knot of fighting, disturbs bone marrow deeply, and corrupt suppuration forms ", is conventionally divided into again acute osteomyelitis and chronic osteomyelitis.To be suppuration bacterium enter blood flow by the focus of infection at other position of health to acute osteomyelitis propagates and be positioned osseous tissue and the inflammation that causes, can pass through the processing of Western medicine emergency injection anti-inflammation infection, and that chronic suppurative osteomyelisis there is no is time qualified, children's, mostly by Acute osteomyelitis, developed; Adult, it mostly is secondary infection after wound and forms.Some cases, because bacterial virulence is low, are just chronic osteomyelitis performance at the beginning.Chronic suppurative osteomyelisis, according to its clinical manifestation and x-ray sign, is generally not difficult to diagnose.

At present clinically to myelitic treatment, general method You Chuan island formula continual rinsing art, sequestrum retains and implants, Papineau modus operandi, bone peeling modus operandi, Wicresoft's External technique, and other conventional surgical hands art, such as puncture suction, the drainage of windowing, sequestrum removal surgery, eliminate bone cavity art, amputation, the sick sacrectomy of bulk, patient's indwelling medicine chain method etc., these operative treatment means are implemented according to the concrete needs of the state of an illness, but no matter be to adopt which kind of operation method, all mean that osteomyelitis has developed into comparatively serious degree.

Theory of Chinese medical science is thought, pyogenic infection of the bone have its inherent pathogenesis, no matter be the inflammation that traumatic injury causes, or pathogenic infection, reality be all cause that body negative and positive are become estranged, space between skin and muscles imbalance, good and evil are unbalance, diagnosis and treatment be targetedly consolidate radically reform, strengthening vital QI to eliminate pathogenic factors, gas is patted and, muscle arteries and veins dredging.

Existing for myelitic Chinese medicinal formulae, for a certain specific passages through which vital energy circulates, allocate often, do not have osteomyelitis prevention effect widely, especially need a kind of proved recipe that can prevent and treat many places meridians pyogenic infection of the bone at present.

Summary of the invention

The invention provides a kind of medicine for the treatment of chronic osteomyelitis, have nourshing Yin and drynsessmoistening prescription, lung heat clearing pathogenic fire reducing, meridians and collaterals dredging, antiphlogistic antibacterial, the broken carbuncle of erosion cellulitis, granulation promoting is filled out the effect of marrow, the chronic osteomyelitis that a variety of causes is caused has good curative effect.

For achieving the above object, technical scheme of the present invention is implemented as follows:

Treat a medicine for chronic osteomyelitis, raw material composition and the parts by weight of making described effective ingredient are:

40～55 parts of 40～55 parts of Herba Violaes of 40～60 parts of Rhizoma Anemarrhenaes of 40～65 parts of Radix Rehmanniaes Preparata of Radix Asparagi

35～50 parts of 35～55 parts of Fructus Lycii of 40～50 parts of Rhizoma Atractylodis of 40～50 parts of Radix puerariae of Herba Taxilli

25～40 parts of 25～45 parts of Radix Saposhnikoviaes of 25～45 portions of Cortex Phellodendris of 30～50 parts of Myrrhas of Fructus Chaenomelis

15～35 parts of 15～35 parts of Radix Scutellariaes of 20～40 parts of Pheretimas of 25～40 parts of Os Sepiae of the Radix Angelicae Dahuricae

5～10 parts, 5～10 parts of Cornu Cervi Pantotrichums of 10～15 portions of Cortex Cinnamomis of 15～30 parts of Borneolum Syntheticums of Endothelium Corneum Gigeriae Galli

Raw material composition and the parts by weight of making described effective ingredient are:

45～50 parts of 45～50 parts of Herba Violaes of 45～55 parts of Rhizoma Anemarrhenaes of 45～60 parts of Radix Rehmanniaes Preparata of Radix Asparagi

38～45 parts of 40～50 parts of Fructus Lycii of 42～48 parts of Rhizoma Atractylodis of 42～48 parts of Radix puerariae of Herba Taxilli

28～35 parts of 30～40 parts of Radix Saposhnikoviaes of 30～40 portions of Cortex Phellodendris of 35～45 parts of Myrrhas of Fructus Chaenomelis

20～30 parts of 20～30 parts of Radix Scutellariaes of 25～35 parts of Pheretimas of 28～35 parts of Os Sepiae of the Radix Angelicae Dahuricae

6～8 parts, 6～8 parts of Cornu Cervi Pantotrichums of 10～13 portions of Cortex Cinnamomis of 20～25 parts of Borneolum Syntheticums of Endothelium Corneum Gigeriae Galli

Raw material composition and the parts by weight of making described effective ingredient are:

48 parts of 48 parts of Herba Violaes of 46 parts of Rhizoma Anemarrhenaes of 52 parts of Radix Rehmanniaes Preparata of Radix Asparagi

42 parts of 45 parts of Fructus Lycii of 45 parts of Rhizoma Atractylodis of 45 parts of Radix puerariae of Herba Taxilli

32 parts of 35 parts of Radix Saposhnikoviaes of 35 portions of Cortex Phellodendris of 40 parts of Myrrhas of Fructus Chaenomelis

25 parts of 25 parts of Radix Scutellariaes of 30 parts of Pheretimas of 32 parts of Os Sepiae of the Radix Angelicae Dahuricae

6 parts, 6 parts of Cornu Cervi Pantotrichums of 11 portions of Cortex Cinnamomis of 22 parts of Borneolum Syntheticums of Endothelium Corneum Gigeriae Galli

Treat a preparation method for the medicine of chronic osteomyelitis, comprise following processing step:

(1) Endothelium Corneum Gigeriae Galli is cleaned and dried, slow fire is ground into powder after slightly frying, and crosses 120 order fine powders, standby.

(2) Radix Asparagi, Radix Rehmanniae Preparata, the Rhizoma Anemarrhenae, Herba Violae, Herba Taxilli, Radix puerariae, Rhizoma Atractylodis, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Pheretima, Borneolum Syntheticum, Cortex Cinnamomi and Cornu Cervi Pantotrichum are blown to skin anti-dandruff, grind into powder, cross 100 order fine powders, standby.

(3) Fructus Lycii, Fructus Chaenomelis, Myrrha, Cortex Phellodendri, Os Sepiae, Radix Scutellariae are added in container, add the water of 8 times of amounts of Six-element medicine gross weight, extract 3～4 hours, filter taking liquid; In remaining residue, add again the water of 4 times of amounts, extract 1～2 hour, filter taking liquid; Merge medicinal liquid twice, be condensed into the thick paste of relative density 1.22～1.24 at 60 ℃.

(4) gained fine powder in step (1) and step (2) is added to mix homogeneously in the thick paste that step (3) makes, in 50～60 ℃ dry after, be ground into 120 object fine powders, incapsulate middle sterilization and make capsule product.

The property of medicine of the present invention's Chinese medicine used is as follows:

Radix Asparagi: sweet in the mouth; Bitter; Cold in nature; Enter lung; Kidney channel.Nourshing Yin and drynsessmoistening prescription; Lung heat clearing pathogenic fire reducing.Cough caused by dryness-heat; Deficiency of YIN chronic cough; Consumption of YIN caused by febrile disease; Interior-heat is quenched one's thirst; Dryness of the intestine constipation; Laryngopharynx swelling and pain.< < book on Chinese herbal medicine converges says that > > carries: " except inclined to one side numbness, bone strengthening marrow person, because lung-heat becomes flaccidity, kidney-heat marrow is withered, and the inclined to one side numbness person of the withered not Rong Ercheng of muscle also." modern medicine study confirmation; Radix Asparagi all has bacteriostasis in various degree to anthrax bacillus, A type and beta hemolytic streptococcus, diphtheria corynebacterium, diphtheroid, Diplococcus pneumoniae, staphylococcus aureus, Staphylococcus citreus, Staphylococcus albus and bacillus subtilis; acute lymphoblastic type leukemia, chronic myelocytic leukemia and the leukocytic dehydrogenase of acute monocyte type leukaemic are had to certain inhibitory action, and can suppress the leukocytic breathing of acute lymphoblastic type leukaemic.

Radix Rehmanniae Preparata: sweet in the mouth; Warm in nature; Return liver; Kidney channel.Enrich blood moist; Benefit essence is filled out marrow.Cure mainly blood tiger sallow; Dizzy cardiopalmus; Hepatic and renal YIN deficiency; Soreness of the waist and knees; The dyspnea with rapid and short breath of suffering from a deficiency of the kidney.< < book on Chinese herbal medicine converges says that > > carries: " the cloudy wound of prolonged illness, newly produces blood and lose, the essential person of institute also." modern medicine study confirmation, Radix Rehmanniae Preparata can strengthen the active content with reducing LPO in serum of GSH-Px, improves plasma A D concentration, also has closely-related effect with medulla hematopoietic system.

The Rhizoma Anemarrhenae: bitter in the mouth; Cold in nature; Enter lung; Stomach; Kidney channel.Clearing away heat-fire; Nourshing Yin and drynsessmoistening prescription; The relieving restlessness of quenching the thirst.Cure mainly epidemic febrile disease; High hot excessive thirst; Cough and asthma; Cough caused by dryness; Constipation; Osteopyrexia and fever; Restlessness of asrhenia type and insomnia; The stranguria with turbid discharge of quenching one's thirst.< < property of medicine opinion > > carries: " cure mainly vexed hot-tempered vexed, the hot labor contact of bone, raw general debility during puerperium, kidney qi labor, the loathing of cold is deficient, suffers from people's void and xerostomia, adds and uses it." modern medicine study confirmation, the Rhizoma Anemarrhenae can suppress the catabolism of liver to hydrocortisone, and multiple pathogenic microorganisms is had to inhibitory action, reduces in addition in addition the effect of blood glucose, inhibition tumor growth and platelet aggregation.

Herba Violae: bitter in the mouth; Pungent; Cold in nature; GUIXIN; Liver Channel.Heat-clearing and toxic substances removing; Removing heat from blood detumescence.Cure mainly jaundice, dysentery, mastitis, conjunctival congestion and swelling pain, pharyngitis, traumatic injury, carbuncle, furuncle swelling toxin, carbuncle carbuncle on the back, erysipelas, venom.< < herbal classic meets former > > to carry: " control the swollen malignant boil of furuncle, hold concurrently and treat carbuncle carbuncle on the back, innominate toxic swelling." modern medicine study confirmation, Herba Violae has the effect that suppresses growth of bacillus tubercle in vitro, and its ethanol extract has inhibitory action to leptospira, and trichophyton is had to inhibitory action, still has in addition the effects such as heat clearing away, detumescence, antiinflammatory.

Herba Taxilli: bitter in the mouth; Sweet; Property is put down; Enter liver; Kidney channel.Invigorating the liver and kidney; Bone and muscle strengthening; Wind-damp dispelling; Antiabortive.Cure mainly soreness of waist and knee joint; A little less than muscles and bones flaccidity; Limbs are hemiplegia; Rheumatic arthralgia; Have a dizzy spell; Frequent fetal movement, metrostaxis.The < < book on Chinese herbal medicine > > that looks for the truth carries: " edge kidney governing bones, sends out blood main, bitter man's kidney, and kidney must mend that muscles and bones is strong, unlikely hemorrhoid repeatly and sensation of aching.Sweet enriching blood, blood must mend send out be subject to its fill with shady and not Fructus Citri tangerinae come off.Therefore in all and lumbago, the sincere disease of muscles and bones, tire are fallen, outer and incised wound, skin rheumatism." modern medicine study confirmation; Herba Taxilli has blood pressure lowering, arrhythmia, increase coronary flow, improves coronary circulation, strengthens cardiac contractile force, reduces myocardial oxygen consumption, anticoagulant, and antithrombotic forms, improves many effects such as microcirculation, antitumor action, treatment hepatitis.

Radix puerariae: sweet in the mouth; Pungent; Property is put down.Enter spleen; Stomach; Lung; Urinary bladder channel.Expelling pathogenic factors from muscles for reducing heat; Deliver and examine; Promoting the production of body fluid to quench thirst; Yang invigorating antidiarrheal.Cure mainly fever caused by exogenous pathogens; Rigidity pain on the head and nape; Measles from the beginning of; Rash goes out not smooth; Epidemic febrile disease is thirsty; Diabetes; Have loose bowels; Dysentery; Hypertension; Coronary heart disease.< < Bencao Jingshu > > carries: " dismiss the key medicine of positive bright epidemic febrile disease pathogenic heat also, therefore main, quench one's thirst, high fever of the body, heat is stopped up septum pectorale and is vomitted.Disperse and rise, the property of wind medicine also, is put main all numbness." modern medicine study shows, is rich in puerarin, 13 kinds of osajins nearly in Radix Puerariae, the isoflavonoid puerarin in Radix puerariae has certain curative effect to hypertension, hyperlipidemia, hyperglycemia and cardiovascular and cerebrovascular disease.

Rhizoma Atractylodis: acrid in the mouth; Bitter; Warm in nature.Return spleen; Stomach; Liver Channel.Drying damp and strengthening spleen; Wind-damp dispelling; Improving eyesight.Cure mainly the spleen and stomach being stranded by dampness; Asthenia drowsiness; Born of the same parents' painful abdominal mass abdominal distention; Inappetence; Vomiting is had loose bowels; Phlegm retention; Damp-edema; Exterior syndrome folder is wet; Heavy sensation of the body pain; Arthromyodynia warm nature; Podomere is ached and is being weighed; Flaccidity folds in a garment; Nyctalopia.The beautiful Chinese catalpa medicine of < < solution > > carries: " dry native diuretic, lets out drink expectorant, clots absorbing, dissipating depression of QI; go Lou, changes addiction, except disease, and reason acid regurgitation removing the necrotic tissue; ward off mountains and rivers communicable subtropical diseases, the flaccidity that returns muscles and bones is soft, the excessive muddiness of urinating clearly." modern medicine study confirmation; the contained volatile oil of Rhizoma Atractylodis has dispelling-wind invigorating stomach effect; contained bitterness also has stomach invigorating, appetitive effect; the enterospasm that has obvious anti-parasympathetic nervous medium acetylcholine to cause; heart is had to slight inhibitory action; blood vessel is had to slight dilating effect, make in addition the hyperfunction effect of spinal reflex.

Fructus Lycii: sweet in the mouth; Property is put down.Return liver; Kidney; Lung meridian.Nourishing the liver; Nourishing kidney; Lung moistening.Cure mainly caused by liver and kidney deficiency; Have a dizzy spell; Visual one clear; Soreness of the waist and knees; The expensive essence of sexual impotence; Cough due to consumptive disease; The taking fluids profusely of quenching one's thirst.The positive > > of < < book on Chinese herbal medicine carries: " improve visual and auditory acuity, adds the solid marrow of essence, strengthens the muscle and bone, and the kind impairment caused by overstrain of mending, especially only quenches one's thirst." modern medicine study confirms, Fructus Lycii scalable body's immunity, can effectively suppress tumor growth and cell mutation, there is slow down aging, the effect of the aspect such as anti-fatty liver, adjusting blood fat and blood glucose, promotion hemopoietic function.

Fructus Chaenomelis: sour in the mouth; Warm in nature.Enter liver; Lung; Kidney; Spleen channel.Relaxing muscles and tendons and activating QI and blood in the collateral; Stomach function regulating removing dampness.Cure mainly rheumatic arthralgia, vague aching of limbs, the contracture of muscle arteries and veins, the convulsion of vomiting and diarrhoea, beriberi edema.The positive > > of < < book on Chinese herbal medicine carries: " treat weakness of the waist and knees, beriberi, tying-in institute is indispensable, the stagnation of QI can and, QI prostration can be admittedly.With the flat stomach of energy, therefore except vomiting, cramp caused by acute vomiting and diarrhea, fall expectorant, dry, row water." modern medicine study confirmation, Fructus Chaenomelis is containing carpaine, papain, Chymosin, carotene etc.; And be rich in 17 kinds with upper amino acid and various nutrient elements, have hepatoprotective fall enzyme, antiinflammatory antibacterial, reduce the effects such as blood fat, stop in addition the synthetic effect of human carcinogen's material nitrosamine.

Myrrha: bitter in the mouth; Pungent; Property is put down; Enter liver; Spleen; The heart; Kidney channel.< < Bencao Jingshu > > carries: " ulna arthralgia and husband's breast abdomen side of body costalgia ", cure mainly traumatic injury, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, ulcer sore pain, loose blood blood stasis removing, reducing swelling and alleviating pain.Modern medicine study confirms, like hormone, scalable thyroid, to have powerful antiinflammatory, sterilization, pain relieving and resist viral effect.

Cortex Phellodendri: bitter in the mouth; Cold in nature.Enter kidney; Urinary bladder channel.Heat clearing and damp drying; Eliminating fire and detoxication.Cure mainly hygropyretic dysentery, have loose bowels, jaundice; Nocturnal emission, stranguria with turbid discharge, leukorrhagia; Hectic fever due to YIN-deficiency consumptive fever; And aphtha of the mouth and tongue; Conjunctival congestion and swelling pain; Skin sore; Skin eczema.< < medicineization justice > > carries: " pathogenic fire reducing can be capit ad calcem, and the thorough marrow of the skin that falls is invariably thoughtful, specially rushes down the fire of kidney and bladder." modern medicine study confirms, Cortex Phellodendri is containing main components such as berberine, obacunone, has the effect of antibacterial, convergence, antiinflammatory, and to symptoms such as various skin noxious dampness, skin infection, effect is good.

Radix Saposhnikoviae: acrid in the mouth; Micro-sweet; Slightly warm in nature.Return lung; Bladder; Liver; Spleen channel.Deliver; Dispel the wind; Victory is wet; Pain relieving.Cure mainly anemofrigid cold; Flu folder is wet; Headache; Giddy; Cold-damp stomachache; Have loose bowels; Rheumatic arthralgia; Spasm of the limbs; Tetanus; Conjunctival congestion; Skin infection; Hernia abdominal mass; Scabies; Rubella.< < Japan hanako materia medica > > carries: " arresting lacrimation and paralysis are slow; tonneau the five internal organs GUAN-pulse; five kinds of strain and seven kinds of impairment, thin damage night sweat, vexed body weight; energy tranquilizing the mind, even gaseous pulse for wind as controlling 36; all labor of man are bad; invigorating middle warmer benefit god, blepharitis marginalis." modern medicine study confirmation, anti-wind energy significantly improves the hypoxia-bearing capability of acute cerebral hypoxia, significantly suppresses the formation of external lipid peroxide of bringing out, and has antioxidant activity, and neurocyte is shielded.

The Radix Angelicae Dahuricae: acrid in the mouth; Warm in nature.Return lung; Spleen; Stomach warp.Expelling wind and removing dampness; Logical surreptitiously pain relieving; Detumescence and apocenosis.Cure mainly headache due to common cold; Supraorbital bone pain; Toothache; Nasal obstruction; Nasal sinusitis; Domination of damp pathogen chronic diarrhea; Women leucorrhea; Ulcer sores; Venom.< < detailed outline > > carries: " control nasal sinusitis, epistaxis, toothache, supraorbital bone pain, large intestine constipation due to pathogenic wind, bleeding urine, married woman's blood dizziness due to wind pathogen fortune, regurgitation of food from the stomach is told food; Solution arsenic poison, snakebite, cutter arrow incised wound." modern medicine study closes, the Radix Angelicae Dahuricae has excitation to central nervous system, can suppress hepatic drug metabolizing enzyme system, has in addition the effects such as antipyretic-antalgic, antiinflammatory, antibacterial, blood pressure lowering, can activate sympathetic system hormone, suppresses lipogenesis.

Os Sepiae: salty in the mouth; Puckery; Warm in nature.Enter liver; Kidney channel.Astringing to arrest bleeding; Treating spontaneous emission and leukorrhagia; Relieving gastric hyperacidity to alleviate stomachache; Removing dampness sore.Cure mainly haematemesis; Hematemesis; Metrorrhagia; Have blood in stool; Epistaxis; Wound hemorrhage; Emission due to deficiency of the kidney spermatorrhea, leucorrhea with red and white discharge, has a stomachache noisy; Belch pantothenic acid; Eczema ulcer.< < Bencao Jingshu > > carry ": enter liver and gall, Shu Yingqi, therefore also main it.Temperature and dampness, therefore the many pus of main skin ulcer are also again." modern medicine study confirms, Os Sepiae can promote ulcer surface inflammation to absorb, and stops hemorrhagely, alleviates local pain, has the effect of obvious promotion bone defect repair, also has in addition the effect of radioprotective and antitumor.

Pheretima: salty in the mouth; Cold in nature.Return liver; Spleen; Urinary bladder channel.Clear gesture relieving convulsion; Suppressing the hyperactive liver to relieve the wind syndrome; Dredge the meridian passage; The diuresis of relievining asthma.Cure mainly calentura heating mad dry; Infantile convulsion is twitched; Headache due to hyperactivity of liver-YANG; Apoplectic hemiplegia; Rheumatic arthralgia; Dyspnea and cough due to lung-heat; Urinary obstruction.< < Compendium of Materia Medica > > carries: " cold in nature and descending, cold in nature therefore can separate all hot diseases, descending former energy diuresis, control sufficient disease and the meridian dredging also." " main typhoid fever malaria, large fanatical tired, and children's's adult urinary obstruction, anxious chronic infantile convulsion, severe and migratory arthralgia pain." modern medicine study proves, Pheretima contains the compositions such as ground LONGSU, lumbrofebrin, vitamin B complex complex, has diuresis, eases pain, relievings asthma, the effect such as blood pressure lowering, antipyretic, convulsion.

Radix Scutellariae: acrid in the mouth; Bitter; Cold in nature.Return lung; Liver; Kidney channel.Heat-clearing and toxic substances removing; Dissipating blood stasis hemostasis; Inducing diuresis to remove edema.Cure mainly pyretic toxicity carbuncle; Have sore throat; Lung abscess; Intestinal carbuncle; Scrofula; Venom; Traumatic injury; Spit blood; Epistaxis; Stranguria with blood; Edema; Ascites and cancer.< < Quanzhou book on Chinese herbal medicine > > carries: " heat clearing away, removing toxic substances, method wind, loose blood, circulation of qi promoting, diuretic, dredging collateral, removing blood stasis with potent drugs, pain relieving.Main stranguria with blood for oral administration, spits blood, epistaxis; External smelting venom, carbuncle, furuncle, innominate toxic swelling." modern medicine study confirmation, Radix Scutellariae has broad-spectrum antibacterial action, also has in addition the effect of antiplatelet aggregation, anticoagulant and blood fat reducing.

Endothelium Corneum Gigeriae Galli: sweet in the mouth; Property is put down.Return spleen; Stomach; Kidney; Urinary bladder channel.Strengthening the spleen to promote digestion; Arresting seminal emission; Xiao Disorder fossil.Cure mainly dyspepsia; Eating accumulation; Vomiting regurgitation; The dysentery of having loose bowels; Infantile malnutrition; Seminal emission; The enuresis; Frequent micturition; Urinary system calculus and cholelithiasis; Mass in the abdomen amenorrhea; Sore throat tonsillitis; Ulcerative gingivitis aphtha.< < Compendium of Materia Medica > > carries: " control children's's intermittent fever due to retention of food, treatment adult (urine) is dripping, regurgitation, and the wine that disappears is long-pending, main inflammation of the throat, tonsillitis, all aphthas, all skin ulcers of ulcerative gingivitis." the clinical confirmation of modern medicine, Endothelium Corneum Gigeriae Galli is used for the treatment of the various diseases such as dyspepsia, chronic gastritis, cholelithiasis, cystitis, vesical calculus, oral ulcer, the seminal emission enuresis, gastric cancer, liver cirrhosis, has good curative effect.

Borneolum Syntheticum: acrid in the mouth; Bitter; Cool in nature.Enter the heart; Lung meridian.The refreshment of having one's ideas straightened out; Heat radiation pain relieving; Improving eyesight removing nebula.Cure mainly apoplexy locked mouth; Calentura coma; Infantile convulsion expectorant fan; Deafness with qi stagnation; Conjunctivitis; Sore throat; Aphtha; Carbuncle; Hemorrhoid; Enterobiasis.The positive > > of < < book on Chinese herbal medicine carries: " the micro-sweet great Xin of taste, it is cool to ice to apply user, and the male power of gas is sharp.This is non-thermal, has the moon also in sun.Kind loose gas, loose blood, loose fire, loose stagnant, sensible, ward off evil, by trusted subordinate's pathogen." modern medicine study confirms; Borneolum Syntheticum can suppress or kill 5 kinds of common bacterias such as staphylococcus aureus, B-mode bacteriolyze streptococcus; Borneolum Syntheticum is learned and can effectively be promoted the effect of other drug Transdermal absorption to be conducive to the control of coronary spasm, can alleviate the myocardial damage due to ischemia.

Cortex Cinnamomi: acrid in the mouth; Bitter; Hot in nature.Enter kidney; Spleen; The heart; Liver Channel.Mend fire supporing yang; Let the fire back to its origin; Dispersing cold for relieving pain; Warming the meridian and promoting blood circulation.Cure mainly insufficiency of kidney-YANG; Gate of vitality's fire aversion to cold and cold limbs; Soreness of the waist and knees; Impotence and seminal emission; Dysuria or frequency; The dyspnea with rapid and short breath of losing heart; The all cards of edema oliguria; Decline of the fire from the gate of life; Fire is Gui Yuan not; Floating YANG; Refusing yang; And heat in the upper and cold in the lower; Flushed complexion cold foot; Dizziness and tinnitus; Dispute is rotten broken; Spleen-kidney vacuity cold; Coldness and pain in the epigastrium; Decreased food intake loose stool; Lumbago due to renal deficiency; Arthralgia due to cold-dampnes; Colic of cold type pain; Cold womb is infertile; Dysmenorrhea amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Carbuncle of yin nature multiple abscess; Or deficiency and coldness carbuncle and ulcer difficulty in discharging of pus; Or do not hold back after bursting.< < property of medicine opinion > > carries: " cure mainly nine types of precordial pain, kill three worms, main removing blood stasis; the tonneau moon closes; control weak foot, numbness, meciless, retention of placenta; except cough with dyspnea; stagnation of QI, gather around numbness, only cold air in abdomen, unbearably painful; main dysentery, nasal polyp.Herbicide wood poison." modern medicine study confirmation, Cortex Cinnamomi contains the compositions such as cinnamic aldehyde, cinnamyl acetate, acetoxyphenyl group the third cheese, has the effect of fragrant stomach invigorating, antipyretic-antalgic, anti-inflammation.

Cornu Cervi Pantotrichum: sweet in the mouth; Salty; Warm in nature.Enter kidney; Liver Channel.Invigorating kidney-YANG; Benefiting essence-blood; Bone and muscle strengthening; Holder sore.Cure mainly kidney yang deficiency; Sexual impotence spermatorrhea; Cold womb is infertile; Asthenia is won thin; Mental fatigue fear of cold; Dizzy; Hiccough and deaf; Aching pain in waist and back; Muscles and bones flaccidity is soft; Children's's five kinds of growth retardation; Woman's bleeding not during menses; Carbuncle of yin nature.< < Bencao Jingshu > > carries: " treat the voluminous symptoms like malaria of asthenia, weakness and emaciation, painful limbs, pain along the spinal column; normal urination, let out essence, hematuria, and broken stagnant blood is at abdomen; loose stranguria caused by urinary stone, carbuncle, heat in bone, cellulitis is itched." modern medicine study confirms; Cornu Cervi Pantotrichum contains abundant aminoacid, lecithin, vitamin and trace element; can improve cellular immunization and the humoral immune function of body; promote lymphocytic conversion; have the effect of immunopotentiating agent; can also increase body defence capability to external world, the immunologic balance in control agent and avoid disease to occur and promote wound healing, sick body rehabilitation.

The present invention compared with prior art, has following beneficial effect:

The present invention adopts Chinese medicine, and selection compatibility is superior, concocts respectively according to the property of medicine, and in the hope of the merit for the treatment of both the principal and secondary aspects of a disease, logical blood is regulated the flow of vital energy, the loose poison of blood stasis dispelling; Good absorbing effect, evident in efficacy, safe and reliable, have no side effect and clinical adverse, through clinical verification, chronic osteomyelitis is had to fabulous curative effect.

The specific embodiment

Below in conjunction with specific embodiment, the present invention is further elaborated.

Embodiment 1

Raw material composition and the weight of effective ingredient of the present invention are:

Radix Asparagi 60g Radix Rehmanniae Preparata 58g Rhizoma Anemarrhenae 52g Herba Violae 52g

Herba Taxilli 48g Radix puerariae 48g Rhizoma Atractylodis 45g Fructus Lycii 46g

Fructus Chaenomelis 46g Myrrha 42g Cortex Phellodendri 42g Radix Saposhnikoviae 38g

Radix Angelicae Dahuricae 38g Os Sepiae 36g Pheretima 32g Radix Scutellariae 32g

Endothelium Corneum Gigeriae Galli 28g Borneolum Syntheticum 13g Cortex Cinnamomi 8g Cornu Cervi Pantotrichum 8g

The processing step of process for preparing medicine of the present invention is:

(1) Endothelium Corneum Gigeriae Galli is cleaned and dried, slow fire is ground into powder after slightly frying, and crosses 100 order fine powders, standby.

(2) Radix Asparagi, Radix Rehmanniae Preparata, the Rhizoma Anemarrhenae, Herba Violae, Herba Taxilli, Radix puerariae, Rhizoma Atractylodis, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Pheretima, Borneolum Syntheticum, Cortex Cinnamomi and Cornu Cervi Pantotrichum are blown to skin anti-dandruff, grind into powder, cross 100 order fine powders, standby.

(3) Fructus Lycii, Fructus Chaenomelis, Myrrha, Cortex Phellodendri, Os Sepiae, Radix Scutellariae are added in container, add the water of 8 times of amounts of Six-element medicine gross weight, extract 3～4 hours, filter taking liquid; In remaining residue, add again the water of 4 times of amounts, extract 1～2 hour, filter taking liquid; Merge medicinal liquid twice, be condensed into the thick paste of relative density 1.22～1.24 at 60 ℃.

(4) add step (3) to make mix homogeneously in thick paste gained fine powder in step (1) and step (2), in 50～60 ℃ dry after, be ground into 120 object medicated powder, incapsulate middle sterilization and make capsule product.

Usage and dosage: every day 3 times, each 6～12g, one hour after meal warm water delivery service, 9 days is a course for the treatment of, and common 1～2 course for the treatment of is effective, and pertinacious disease needs 3～4 courses for the treatment of.

Embodiment 2

Raw material composition and the weight of effective ingredient of the present invention are:

Radix Asparagi 55g Radix Rehmanniae Preparata 50g Rhizoma Anemarrhenae 46g Herba Violae 46g

Herba Taxilli 46g Radix puerariae 48g Rhizoma Atractylodis 46g Fructus Lycii 45g

Fructus Chaenomelis 42g Myrrha 38g Cortex Phellodendri 38g Radix Saposhnikoviae 34g

Radix Angelicae Dahuricae 35g Os Sepiae 32g Pheretima 28g Radix Scutellariae 28g

Endothelium Corneum Gigeriae Galli 23g Borneolum Syntheticum 12g Cortex Cinnamomi 7g Cornu Cervi Pantotrichum 7g

Process for preparing medicine processing step and the usage and dosage of the present embodiment are identical with embodiment 1.

Embodiment 3

Raw material composition and the weight of effective ingredient of the present invention are:

Radix Asparagi 52g Radix Rehmanniae Preparata 46g Rhizoma Anemarrhenae 48g Herba Violae 48g

Herba Taxilli 45g Radix puerariae 45g Rhizoma Atractylodis 45g Fructus Lycii 42g

Fructus Chaenomelis 40g Myrrha 35g Cortex Phellodendri 35g Radix Saposhnikoviae 32g

Radix Angelicae Dahuricae 32g Os Sepiae 30g Pheretima 25g Radix Scutellariae 25g

Endothelium Corneum Gigeriae Galli 22g Borneolum Syntheticum 11g Cortex Cinnamomi 6g Cornu Cervi Pantotrichum 6g

Process for preparing medicine processing step and the usage and dosage of the present embodiment are identical with embodiment 1.

Clinical data:

1, case selection

The routine clinical observation of osteomyelitis (co) 67 of selecting my institute or outer court to make a definite diagnosis, patient is divided into two groups at random, treatment group 34 examples, wherein male's 23 examples, women's 11 examples, 27～66 years old age, 43.6 years old mean age, the shortest person of the course of disease 6 months, elder 17 years, average 7.8 years.Matched group 33 examples, wherein male's 21 examples, women's 12 examples, 26～71 years old age, 46.2 years old mean age, the shortest person of the course of disease 7 months, elder 14 years, average 6.3 years.Two groups of qualifications and record of service are basically identical, without significant difference, have comparability.

2, treatment group patient takes medicine of the present invention, adult every day 3 times, and each 6～12g, warm water delivery service in a hour after meal, 9 days is a course for the treatment of, and common 1～2 course for the treatment of is effective, and pertinacious disease needs 3～4 courses for the treatment of.Random one of the following sample medicine of selecting of matched group, in strict accordance with package insert, take:

Fosfomycin calcium capsule, powerful amoxicillin, victory Chinese mugwort, flucloxacillin sodium capsule, amoxycillin-potassium clavulanate tablets (7:1), spiramycin sheet, osteitis spirit sheet, happy clean, Kang Ni, cefalexin Tablet, peace are strange, clindamycin Hydrochloride capsule, tinidazole tablets

3, efficacy determination:

(1) recovery from illness: affected part swelling disappears, tenderness sense disappears, and the heating paresthesia that goes cold all over disappears, and X-ray film demonstration bone destruction is disappeared.

(2) take a turn for the better: affected part swelling alleviates, and tenderness sense alleviates, and the heating paresthesia that goes cold all over disappears, X-ray film shows bone destruction improving situation.

(3) invalid: symptom and X-ray film show that bone destruction situation is front without significant change with treatment.

4, result

Take in the treatment group of medicine of the present invention, cure 21 examples, 9 examples that take a turn for the better, invalid 4 examples, cure rate 62%, total effective rate 88%.

In matched group, cure 2 examples, 19 examples that take a turn for the better, invalid 12 examples, cure rate 6%, total effective rate 64%.

Above result demonstration, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.

Model case is given an example:

1, old × ×, man, 61 years old, peasant.Patient's readme arm, leg joint swell and ache, left lower limb knee joint bottom redness, and slightly ulceration causes the prolonged ulcer not healing, and broken skin ulcer is suppurated, and tenderness sense is strong, long-term disunion.Repeatedly attempt drug for diminishing inflammation and antibiosis treatment, outbreak, once dropped out fritter sequestrum in 2010 repeatedly, and swollen joint increases slightly, existing lopsided symptom, and walking sitting and lying has lost capacity of will.After taking 2 courses for the treatment of of capsule of the present invention, the symptom that swells and ache is alleviated to some extent, and the open sore part phenomenon of suppurating alleviates, and tenderness sense thaws; Continue to take after 3 courses for the treatment of of capsule of the present invention, open sore part granulation promoting, joint still has enlargement phenomenon, but this disappearance of tenderness sensillary base; Carrying out at present the treatment of the 7th course for the treatment of.

2, state × ×, female, 28 years old, secondary school teachers.This patient, because of unexpected traumatic injury on school sports, causes elbow joint congestion and swelling pain, does not prolongedly heal.By X-ray film, be diagnosed as subperiosteal abscess, Soft Tissue Abscess: An Experimental.Through antibacterial therapy after a while, effect is not remarkable, pain aggravation.During Lai Wo institute diagnosis and treatment, find that there is the probability that fistula hole occurs, then at it, continue, on the basis of intravenous injection anti-inflammation, to be aided with capsule of the present invention, every day three times, each oral 8g, through the treatment of 2 courses for the treatment of, X-ray film shows that its subperiosteal abscess and Soft Tissue Abscess: An Experimental all disappear, red and swollen phenomenon disappears, pain disappears, and follows up a case by regular visits to half a year, not recurrence.

Claims (4)

1. a medicine for the treatment of chronic osteomyelitis, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:

40～55 parts of 40～55 parts of purple DIHUA fourths of 40～60 parts of Rhizoma Anemarrhenaes of 40～65 parts of Radix Rehmanniaes Preparata of Radix Asparagi

35～50 parts of 35～55 parts of Fructus Lycii of 40～50 parts of Rhizoma Atractylodis of 40～50 parts of Radix puerariae of Herba Taxilli

25～40 parts of 25～45 parts of Radix Saposhnikoviaes of 25～45 portions of Cortex Phellodendris of 30～50 parts of Myrrhas of Fructus Chaenomelis

15～35 parts of 15～35 parts of Radix Scutellariaes of 20～40 parts of Pheretimas of 25～40 parts of Os Sepiae of the Radix Angelicae Dahuricae

5～10 parts, 5～10 parts of Cornu Cervi Pantotrichums of 10～15 portions of Cortex Cinnamomis of 15～30 parts of Borneolum Syntheticums of Endothelium Corneum Gigeriae Galli.

2. a kind of medicine for the treatment of chronic osteomyelitis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:

45～50 parts of 45～50 parts of purple DIHUA fourths of 45～55 parts of Rhizoma Anemarrhenaes of 45～60 parts of Radix Rehmanniaes Preparata of Radix Asparagi

38～45 parts of 40～50 parts of Fructus Lycii of 42～48 parts of Rhizoma Atractylodis of 42～48 parts of Radix puerariae of Herba Taxilli

28～35 parts of 30～40 parts of Radix Saposhnikoviaes of 30～40 portions of Cortex Phellodendris of 35～45 parts of Myrrhas of Fructus Chaenomelis

20～30 parts of 20～30 parts of Radix Scutellariaes of 25～35 parts of Pheretimas of 28～35 parts of Os Sepiae of the Radix Angelicae Dahuricae

6～8 parts, 6～8 parts of Cornu Cervi Pantotrichums of 10～13 portions of Cortex Cinnamomis of 20～25 parts of Borneolum Syntheticums of Endothelium Corneum Gigeriae Galli.

3. a kind of medicine for the treatment of chronic osteomyelitis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:

48 parts of 48 parts of purple DIHUA fourths of 46 parts of Rhizoma Anemarrhenaes of 52 parts of Radix Rehmanniaes Preparata of Radix Asparagi

42 parts of 45 parts of Fructus Lycii of 45 parts of Rhizoma Atractylodis of 45 parts of Radix puerariae of Herba Taxilli

32 parts of 35 parts of Radix Saposhnikoviaes of 35 portions of Cortex Phellodendris of 40 parts of Myrrhas of Fructus Chaenomelis

25 parts of 25 parts of Radix Scutellariaes of 30 parts of Pheretimas of 32 parts of Os Sepiae of the Radix Angelicae Dahuricae

6 parts, 6 parts of Cornu Cervi Pantotrichums of 11 portions of Cortex Cinnamomis of 22 parts of Borneolum Syntheticums of Endothelium Corneum Gigeriae Galli.

4. a preparation method for the medicine of the treatment chronic osteomyelitis as described in claim 1-3 any one, is characterized in that: comprise following processing step:

(1) Endothelium Corneum Gigeriae Galli is cleaned and dried, slow fire is ground into powder after slightly frying, and crosses 120 order fine powders, standby;

(2) Radix Asparagi, Radix Rehmanniae Preparata, the Rhizoma Anemarrhenae, purple DIHUA fourth, Herba Taxilli, Radix puerariae, Rhizoma Atractylodis, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Pheretima, Borneolum Syntheticum, Cortex Cinnamomi and Cornu Cervi Pantotrichum are blown to skin anti-dandruff, grind into powder, cross 100 order fine powders, standby;

(3) Fructus Lycii, Fructus Chaenomelis, Myrrha, Cortex Phellodendri, Os Sepiae, Radix Scutellariae are added in container, add Six-element medicine

The water of 8 times of amounts of gross weight, extracts 3～4 hours, filters taking liquid; In remaining residue, add again the water of 4 times of amounts, extract 1～2 hour, filter taking liquid; Merge medicinal liquid twice, be condensed into the thick paste of relative density 1.22～1.24 at 60 ℃;

(4) add step (3) to make mix homogeneously in thick paste gained fine powder in step (1) and step (2), in 50～60 ℃ dry after, be ground into 120 object fine powders, incapsulate middle sterilization and make capsule product.