CN102944500B - For the lane device of tracer liquid viscosity and system and application thereof - Google Patents
For the lane device of tracer liquid viscosity and system and application thereof Download PDFInfo
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- CN102944500B CN102944500B CN201210441254.8A CN201210441254A CN102944500B CN 102944500 B CN102944500 B CN 102944500B CN 201210441254 A CN201210441254 A CN 201210441254A CN 102944500 B CN102944500 B CN 102944500B
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Abstract
The invention belongs to bioengineering field, in particular to checkout equipment and the technology of micro-fluidic viscosity, for the lane device of tracer liquid viscosity, the functional unit of described lane device comprises measures main channel and buffer channel, described buffer channel connects with described measurement main channel and parallel, the diameter of described buffer channel is greater than the diameter measuring main channel, and the length of described buffer channel is less than the length measuring main channel, and described measurement main channel and buffer channel are right cylinder passage; Described lane device contains at least one functional unit, preferably the multiple described functional unit of set; The assay method of viscosity is tried to achieve based on the formula of Poiseuille law; This device is micro updating device, and accuracy and precision is high; This method repeatability is high, and the reagent of employing is few, can be used for the mensuration of Newton and non-Newton fluid.
Description
Technical field
The invention belongs to apparatus field, particularly the checkout equipment of micro-fluidic viscosity and technology.
Background technology
Viscosity and measurement thereof all have a wide range of applications in many departments of national economy, such as oil (oil extraction with transport, the grade estimation of petroleum products, the mixing etc. of oil product), chemical industry (paint, coating, bonding agent, three large synthetic material---plastics, rubber, synthon etc.), light industry (weaving, papermaking, cosmetics etc.), food (cream, chocolate, jam etc.), building materials (glass, pottery, cement etc.), coal, fields such as metallurgical (motlten metal and slags etc.), viscosity measurement is related to production control flow process, ensure safety in production, control and evaluate the aspects such as product quality, special in field of medicaments, hemorheological property (comprises blood viscosity, plasma viscosity etc.) directly have influence on the resistance of blood flow, closely related with the multiple pathological processes of human body, that the cardiovascular and cerebrovascular diseases such as headstroke, coronary heart disease, hypertension, high fat of blood, artery sclerosis commonly use one of clinical detection index, one of viscosity measurements important means becoming medical diagnosis at present.
In recent years, along with the rise of microfluidic chip technology, the application of viscosity measurement in scientific research is also more and more subject to people's attention.Micro-fluidic chip (microfluidicchip) refers to: by Micrometer-Nanometer Processing Technology by function element such as microchannel, Micropump, micro-valve, micro-reservoir, microelectrode, micro-detecting element window and connectors as integrated circuit, make them be integrated on chip material; Be intended to by the sample preparation involved by the fields such as biological and chemical, biological with chemical reaction, be separated and the basic operation unit such as detect and be integrated on the chip of a piece several square centimeters, in order to complete different biological or chemical reactions, and its product is analyzed.Fluid flowing in research chip is one of key factor of the design affecting micro-fluidic chip, and the viscosity relationship of fluid is to the precise hard_drawn tuhes of the flowing of inner fluid passage, and therefore, viscosity measurement technology is one of emphasis becoming researcher also.
Tradition method for detecting viscosity mainly contains capillary tube technique and rotary process two kinds of main stream approach, capillary tube technique Main Basis Poiseuille law is measured, conventional is gravity-type capillary tube technique (being mainly used in petroleum products), and compression type capillary tube technique etc.It is also measure the important method of polymer substance molecular weight that capillary tube technique measures Viscosity of Polymer Solutions.Rotary process viscosity measurement is also a kind of measuring method of relative maturity, and the rotating speed difference of the viscosity moment or object that act on object by test fluid determines the viscosity of fluid.Have many famous brand name companies to develop a series of rotary rheometer to be in the world widely used in various industrial trade.
For the measurement requirement of different material, also have falling ball method, vibratory drilling method, flat band method, viscosity agar diffusion method and various modification methods on this basis.Along with the development of science and technology, Viscosity Measurement Methods is also towards microminiaturized and quick, accurate future development, in recent years, many emerging microviscometer designs are studies have reported that, these microviscometer consumptions only need microlitre and even receive upgrading not, and even can measure the rheological properties of Bacterial biofilm, even the viscosity of cell liquid also becomes possibility.
Summary of the invention
The object of the present invention is to provide a kind of viscosity apparatus, described viscosity apparatus is the micro updating viscosity detecting device and system that design based on Poiseuille law, and degree of accuracy is high, and configuration is simple.
For achieving the above object, technical scheme of the present invention is:
For the lane device of tracer liquid viscosity, the functional unit of described lane device comprises measures main channel and buffer channel, one end of described buffer channel connects with described measurement main channel and parallel, the diameter of described buffer channel is greater than the diameter measuring main channel, the length of described buffer channel is less than the length measuring main channel, and described measurement main channel and buffer channel are right cylinder passage.Described lane device contains at least one functional unit, preferably the multiple described functional unit of set.
Preferably, described lane device is micro fluidic device, and described measurement main channel length is no less than 4 centimetres, and diameter is 0.15-1 millimeter; The diameter of described buffer channel is 10-20 times of described measurement main channel.Described lane device is prepared from transparent material, selects transparent material to be convenient to observe.When the length measuring main channel is less than 4 centimetres, the result precision step-down of test; The diameter of described main channel selects 0.15-1 millimeter, embodies the advantage of " trace "; But when diameter is less than 0.15 millimeter, the result precision step-down of test.
Preferably, described measurement main channel and buffer channel are horizontal channel.Horizontal channel can reduce the error that liquid potential difference is brought.But even so, the error brought of the liquid potential difference of trace level itself is less.
Preferably, the other end of described measurement main channel is connected with tension force and offsets passage.
Preferably, the diameter of described tension force counteracting passage is 0.9-1.1 times of the diameter of buffer channel, and the length of described tension force counteracting passage is 0.9-1.1 times of the length of buffer channel.
Preferably, the other end of described buffer channel is connected with feed tube.In the utility appliance that the setting of feed tube can avoid liquid to omit outside micro-fluidic viscosity apparatus.
Preferably, described lane device is made up of transparent material.Transparent material is convenient to observation.
System containing described lane device, described system comprises thermostat and is placed in the lane device of thermostat, and the buffer channel of described lane device or feed tube are connected with constant voltage drive unit, and the top of described buffer channel is provided with video-unit.
Two of object of the present invention is the detection method providing liquid viscosity, and the method is based on Poiseuille law, and the method error is little, expends reagent little, has very high repeatability and high precision.
Measure the method for liquid viscosity based on described lane device, specifically comprise the following steps:
The parameter measurement of A titer and testing sample
Add in described lane device by the titer of known-viscosity with constant pressure p, described titer flows to described measurement main channel from described buffer channel, and observe described titer flow through the time t of described buffer channel distance l and needs, wherein, distance l is designated as l
mark, the time, t was designated as t
mark; Add in described lane device by testing sample with constant pressure p, described testing sample flows to described measurement main channel from described buffer channel, and observe described titer flow through the time t of described buffer channel distance l and needs, wherein, distance l is designated as l
survey, the time, t was designated as t
survey;
The viscosity calculations of B testing sample
The l that steps A is recorded
mark, t
mark, l
surveyand t
surveysubstitute in formula I, try to achieve the viscosity number of testing sample; In described formula I, η
markfor the viscosity number of described titer, for known; η
surveyfor the viscosity number η of described testing sample;
I。
Or
Measure the method for liquid viscosity based on described lane device, specifically comprise the following steps:
The parameter measurement of A titer and testing sample
Add in described lane device by the titer of known-viscosity with constant pressure p, described titer flows to described measurement main channel from described buffer channel, and observe described titer in official hour t flow through described buffer channel distance l, wherein, distance l is designated as l
mark; Add in described lane device by testing sample with constant pressure p, described testing sample flows to described measurement main channel from described buffer channel, and observe described titer in official hour t flow through described buffer channel distance l, wherein, distance l is designated as l
survey;
The viscosity calculations of B testing sample
The l that steps A is recorded
markand l
surveysubstitute in formula II, try to achieve the viscosity number of testing sample; In described formula II, η
markfor the viscosity number of described titer, for known; η
surveyfor the viscosity number η of described testing sample;
II。
Further, in steps A, above described buffer channel, install the video-unit for catching liquid flow, described video-unit is provided with video recording software, described l
markand l
surveymonitored by video-unit and compare the fluid mobility status pixel of different time sections and calculate and obtain.
Further, described method is carried out under constant temperature.
Beneficial effect of the present invention is: 1) the detection reagent of micro fluidic device employing is few; 2) this method accuracy is high; 3) this method favorable repeatability; 3) because drive unit can give constant pressure, in pressure one timing, flowing velocity is certain, and shear rate is also certain, so, the viscosity of the fluid under specific shear rate can be detected, can be used for the detection of Newton and non-Newton fluid; 4) little by the data error of shooting acquisition equipment measurement; 5) this device manufacture craft is simple, without the need to by exact instrument; 6) this installation cost is low; 7) this device is suitable for multisample detection, can reduce the error that space, time and temperature are brought to greatest extent.
Accompanying drawing explanation
Fig. 1 is the structural representation of this lane device.
Fig. 2 is the system architecture schematic diagram of lane device.
Embodiment
Illustrated embodiment is to be described content of the present invention better, but is not that content of the present invention is only limitted to illustrated embodiment.So those of ordinary skill in the art carry out nonessential improvement and adjustment according to foregoing invention content to embodiment, still belong to protection scope of the present invention.
Micro fluidic device: biological, chemistry, medical analysis process the basic operation unit such as sample preparation, reaction, separation, detection is integrated on the chip of one piece of micro-meter scale, automatically completes analysis overall process.
Part I is based on the formula of Poiseuille law
Poiseuille law: when fluid does laminar motion in horizontal pipe, pressure difference Δ p (p) at its volume flow Q and pipe two ends, measure the radius r of main channel, (described measurement main channel) length L, and the viscosity number η of fluid there is following relation:
(formula III);
(formula IV);
(formula V)
(formula VI)
(formula I)
When t survey=t timestamp, have formula II as follows:
In above-mentioned formula, S is the sectional area of described buffer channel 2, v is liquid (Newtonian fluid or the non-Newtonian fluid) average flow velocity in described buffer channel 2, t is for liquid is in the time of flowing required for certain distance in described buffer channel 2, and l is that liquid flows the distance of t time in described buffer channel 2.
The preparation of the micro-fluidic viscosity apparatus of Part I embodiment 1-8
Embodiment 1 is for the lane device of tracer liquid viscosity, the functional unit of described lane device 5 comprises measures main channel 1 and buffer channel 2, described buffer channel 2 and described measurement main channel 1 level connection joint, the diameter of described buffer channel 2 is greater than the diameter measuring main channel 1, the length of described buffer channel 2 is less than the length measuring main channel 1, and described measurement main channel 1 and buffer channel 2 are right cylinder passage.
Embodiment 2 is as the preferred embodiment of embodiment 1, and described lane device 5 is micro fluidic device, and described measurement main channel 1 length is no less than 4 centimetres, and diameter is 0.15-1 millimeter; The diameter of described buffer channel 2 is 10-20 times of described measurement main channel 1.The micro fluidic device of the present embodiment, main channel 1 length is not 6.5 centimetres, and diameter is 0.2 millimeter; The diameter of described buffer channel 2 is 12 times of described measurement main channel 1.
Embodiment 3 is as the preferred embodiment of embodiment 2, and described measurement main channel 1 and buffer channel 2 are horizontal channel.
Embodiment 4 is as the preferred embodiment of embodiment 3, and the other end of described measurement main channel 1 is connected with tension force and offsets passage 3.
Embodiment 5 is as the preferred embodiment of embodiment 4, and diameter and the length of described tension force counteracting passage 3 are respectively the diameter of buffer channel 2 and 0.9-1.1 times of length.The counteracting of tension force described in the present embodiment passage 3 is identical with length with the diameter of buffer channel 2.
Embodiment 6 is as the preferred embodiment of embodiment 5, and described buffer channel 2 is connected with feed tube 4.
Embodiment 7 is as the preferred embodiment of embodiment 6, and described lane device is made up of transparent material, and the present embodiment selects dimethyl silicone polymer (PDMS).
Embodiment 8
System containing described lane device, described system comprises thermostat 6 and is placed in the lane device 5 (lane device of embodiment 7) of thermostat 6, buffer channel 2 or the feed tube 4 of described lane device 5 are connected with constant voltage drive unit, described constant voltage drive unit is U-shaped pipe pressure device, and its use principle can refer to " the manometric analysis of uncertainty in measurement of U-shaped and the improvement " of Ma Shilong etc.; The top of described buffer channel 2 is provided with catches the video-unit 7 of liquid at buffer channel mobility status, and described screen device 7 has video recording software.Light source 8 is equipped with in the top of video-unit 7.
The application of Part II lane device
Embodiment 9
(1) method step
Prepare the method for the systematic survey water viscosity containing described lane device based on embodiment 8, specifically comprise the following steps:
The parameter measurement of A titer and testing sample
The titer of known-viscosity is added in described lane device 5 with constant pressure p, described titer flows to described measurement main channel (1) from described buffer channel 2, observation described titer (water under 20 DEG C of conditions in official hour t, its viscosity number is 1.002mPas) flow through described buffer channel 2 apart from l, wherein, distance l is designated as l
mark;
By the testing sample (water under condition of different temperatures, refer to table 1) add in described lane device with constant pressure p, described testing sample flows to described measurement main channel 1 from described buffer channel 2, observation described titer in official hour t flows through described buffer channel 2 apart from l, wherein, distance l is designated as l
survey.When with shooting acquisition equipment to l
surveyand l
markwhen measuring, distance l is converted by pixel, writes " the process application of MATLAB image/video and example " book with reference to Yang Gaobo etc.Except with shooting acquisition equipment, conventional distance measurement tools all can be used for measuring distance l.
The viscosity calculations of B testing sample
The l that steps A is recorded
markand l
surveysubstitute in formula II, try to achieve the viscosity number of testing sample; In described formula II, η
markfor the viscosity number of described titer, for known; η
surveyfor the viscosity number of described testing sample;
II。
(2) screen device is used to measure l
markand l
surveyvalue
Refer to " the process application of MATLAB image/video and example " book that Yang Gaobo etc. writes.Or Yu Songyu, perigene China, Zhang Rui etc. write " Digital Image Processing " book.
(3) result
Table 1 testing result
Compared with the practical viscosity value announced, the measuring error of this chip is less than 1%, and relative error is 0.8986%.
Embodiment 10
(1) method step
Measure the method for liquid viscosity based on lane device according to claim 1, specifically comprise the following steps:
The parameter measurement of A titer and testing sample
The titer of known-viscosity is added in described lane device with constant pressure p, described titer flows to described measurement main channel 1 from described buffer channel 2, observe the described titer (water under 20 DEG C of conditions, its viscosity number is 1.002mPas) flow through the time t of described buffer channel 2 apart from l and needs, wherein, distance l is designated as l
mark, the time, t was designated as t
mark; Add in described lane device by testing sample with constant pressure p, described testing sample flows to described measurement main channel 1 from described buffer channel 2, and observe described titer flow through the time t of described buffer channel 2 apart from l and needs, wherein, distance l is designated as l
survey, the time, t was designated as t
survey;
The viscosity calculations of B testing sample
The l that steps A is recorded
mark, t
mark, l
surveyand t
surveysubstitute in formula I, try to achieve the viscosity number of testing sample; In described formula I, η
markfor the viscosity number of described titer, for known; η
surveyfor the viscosity number of described testing sample;
I。
(2) screen device is used to measure l
markand l
surveyvalue
Refer to " the process application of MATLAB image/video and example " book that Yang Gaobo etc. writes.
(3) result
Use this method to test DMEM high glucose medium under 37 DEG C of conditions, its viscosity number η is 0.7439 milli handkerchief second (mPas).
What finally illustrate is, above embodiment is only in order to illustrate technical scheme of the present invention and unrestricted, although with reference to preferred embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that, can modify to technical scheme of the present invention or equivalent replacement, and not departing from aim and the scope of technical solution of the present invention, it all should be encompassed in the middle of right of the present invention.
Claims (11)
1. containing the system for the lane device of tracer liquid viscosity, it is characterized in that, described lane device (5) comprises measures main channel (1) and buffer channel (2), one end and one end level connection joint measuring main channel (1) of described buffer channel (2), the diameter of described buffer channel (2) is greater than the diameter measuring main channel (1), the length of described buffer channel (2) is less than the length measuring main channel (1), described measurement main channel (1) and buffer channel (2) are right cylinder passage, described system comprises thermostat (6) and is placed in the lane device (5) of thermostat (6), buffer channel (2) or the feed tube (4) of described lane device (5) are connected with constant voltage drive unit, the top of described buffer channel (2) is provided with video-unit (7).
2. system according to claim 1, is characterized in that, described measurement main channel (1) length is no less than 4 centimetres, and diameter is 0.15-1 millimeter; The diameter of described buffer channel (2) is 10-20 times of described measurement main channel (1).
3. system according to claim 1, is characterized in that, described measurement main channel (1) and buffer channel (2) are horizontal channel.
4. system according to claim 1, is characterized in that, the other end of described measurement main channel (1) is connected with tension force and offsets passage (3).
5. system according to claim 4, it is characterized in that, the diameter of described tension force counteracting passage (3) is 0.9-1.1 times of the diameter of buffer channel (2), and the length of described tension force counteracting passage (3) is 0.9-1.1 times of the length of buffer channel (2).
6. system according to claim 1, is characterized in that, the other end connection of described buffer channel (2) is provided with feed tube (4).
7. system according to claim 1, is characterized in that, described lane device is made up of transparent material.
8., based on the method for systematic survey liquid viscosity according to claim 1, it is characterized in that, specifically comprise the following steps:
The parameter measurement of A titer and testing sample
The titer of known-viscosity is added in described lane device with constant pressure p, described titer flows to described measurement main channel (1) from described buffer channel (2), described titer is observed to flow through the time t of described buffer channel (2) distance l and needs, wherein, distance l is designated as l
mark, the time, t was designated as t
mark; Testing sample is added in described lane device with constant pressure p, testing sample flows to described measurement main channel (1) from described buffer channel (2), observation testing sample is through the time t of described buffer channel (2) distance l and needs, and wherein, distance l is designated as l
survey, the time, t was designated as t
survey;
The viscosity calculations of B testing sample
The l that steps A is recorded
mark, t
mark, l
surveyand t
surveysubstitute in formula I, try to achieve the viscosity number of testing sample; In described formula I, η
markfor the viscosity number of described titer, for known; η
surveyfor the viscosity number η of described testing sample,
9. measure the method for liquid viscosity based on lane device according to claim 1, it is characterized in that, specifically comprise the following steps:
The parameter measurement of A titer and testing sample
The titer of known-viscosity is added in described lane device (5) with constant pressure p, described titer flows to described measurement main channel (1) from described buffer channel (2), observation described titer in official hour t flows through described buffer channel (2) distance l, wherein, distance l is designated as l
mark; Testing sample is added in described lane device with constant pressure p, testing sample flows to described measurement main channel (1) from described buffer channel (2), in official hour t, testing sample is through described buffer channel (2) distance l in observation, and wherein, distance l is designated as l
survey;
The viscosity calculations of B testing sample
The l that steps A is recorded
markand l
surveysubstitute in formula II, try to achieve the viscosity number of testing sample; In described formula II, η
markfor the viscosity number of described titer, for known; η
surveyfor the viscosity number η of described testing sample
10. method according to claim 8 or claim 9, is characterized in that: in steps A, and the described distance l video-unit (7) of catching liquid flow is measured, and described video-unit is provided with video recording software.
11. methods according to claim 10, is characterized in that: described method is carried out under constant temperature.
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| CN105547922A (en) * | 2015-12-11 | 2016-05-04 | 清华大学 | Microviscosimeter based on micro/nano channel |
| CN106680148A (en) * | 2017-03-10 | 2017-05-17 | 钦州学院 | Viscosity testing device and testing method thereof |
| CN108872019B (en) * | 2017-05-11 | 2021-02-05 | 中国石化仪征化纤有限责任公司 | Online detection device and detection method for PPTA molecular weight in aramid solution |
| CN108872016B (en) * | 2018-07-13 | 2020-10-16 | 燕山大学 | Liquid dynamic viscosity measuring platform based on electroosmosis principle |
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