CN102940839B

CN102940839B - Traditional Chinese medicine composition for treating chronic atrophic gastritis

Info

Publication number: CN102940839B
Application number: CN201210347287.6A
Authority: CN
Inventors: 孙红霞; 柳晖
Original assignee: Individual
Current assignee: Sun Hongxia
Priority date: 2012-09-19
Filing date: 2012-09-19
Publication date: 2014-06-25
Anticipated expiration: 2032-09-19
Also published as: CN102940839A

Abstract

The invention relates to a traditional Chinese medicine composition for treating chronic atrophic gastritis. The medicine is composed of the following Chinese medicinal materials, by weight: 10-40 parts of Fructus Trichosanthis, 5-20 parts of Rhizoma Pinelliae, 3-15 parts of Rhizoma Coptidis, 5-25 parts of Fructus Aurantii Immaturus, 5-20 parts of Poria cocos, 5-25 parts of bighead atractylodes rhizome, 5-20 parts of szechwan Chinaberry fruit, 3-15 parts of Radix Aucklandiae, 5-25 parts of the root of red-rooted salvia, 3-15 parts of Fructus Amomi, 5-20 parts of Angelica sinensis, 5-20 parts of raw pollen typhae, and 3-10 parts of liquorice. The traditional Chinese medicine composition provided by the invention has effects of tonifying spleen, appetizing, tretching liver to smooth qi, resolving dampness, dredging stasis, clearing heat, nourishing yin, promoting blood circulation and dispersing blood stasis, and has advantages of obvious curative effect on chronic atrophic gastritis, reliable function, wide medicinal source, simple preparation, and no toxic or side effect.

Description

A kind of Chinese medicine composition for the treatment of chronic atrophic gastritis

Technical field

The present invention relates to a kind of medicinal preparation of not determining structure of traditional herbal medicines, especially a kind of Chinese medicine composition for the treatment of chronic atrophic gastritis.

Background technology

A kind of common digestive system disease of chronic atrophic gastritis take the atrophy of gastric mucosa body of gland as feature is digestive system common disease.It is reported: in China, chronic atrophic gastritis sickness rate accounts for the crowd's of being examined 13.8%.Clinical manifestation be abdominal distention, upper abdominal pain or epigastric discomfort, early full sense, a little polyphagia abdominal distention is more obvious, even there is belch, nauseating, dyspepsia, tired, become thin, poor appetite, the symptoms such as anemia, Most patients can have epigastrium causalgia, distending pain, dull pain or distension, painful abdominal mass vexed, especially with after eating for very, the symptoms such as inappetence, nauseating, belch, constipation or diarrhoea.Pathogenic factor has a lot, as the hobby of arteriosclerosis, stomach Insufficience of blood flow, cigarette,wine and tea etc. all easily damages the barrier function of gastric mucosa and causes chronic atrophic gastritis.Show according to epidemiology, the incidence rate of Chronic Atrophic Gastritis Patients gastric cancer is apparently higher than general population.Treatment chronic atrophic gastritis is to stop chronic atrophic gastritis to develop to reduce the effective means of gastric cancer incidence rate to gastric cancer.Modern medicine still lacks desirable Therapeutic Method, can only carry out symptomatic treatment and the treatment of protection gastric mucosa.For example upper abdomen distending pain, can take the Chinese medicine preparation that the spleen invigorating such as SANJIU WEITAI are regulated the flow of vital energy; Abdeminal pain, feel sick, belch can use cisapride, motilium etc.; As gastric mucosa has course inflammatory activity, the helicobacter pylori positive, can take the preparation of bismuth-containing as tripotassium dicitratobismuthate etc.The Chinese medicine of A, E, C, vitamin B group and QI invigorating nourishing the stomach recovers favourable to gastric mucosa.But there is the undesirable deficiency of curative effect.

Chronic atrophic gastritis is equivalent to the categories such as motherland's medical science " gastric abscess ", and its sick position is at stomach.In recent years, extensive and fruitful research has also been carried out in the aspect such as dialectical, the rule for the treatment of side's medicine of the diagnosis of traditional Chinese medical science bound pair chronic atrophic gastritis, infrastest.

The traditional Chinese medical science thinks, primary disease is many because cold-evil stagnates, due to the factor such as unsuccessful, the infection at a slow speed of diet damage, feelings will, medicine and heredity.Stomach is positive internal organs, the many blood of many gas, with lead to reduce to suitable, preferring moisture to dryness, if cold-evil stagnates, eating and drinking without temperance, feelings will are unsuccessful, infection, medicine etc., all can damage stomach internal organs, cause stomach-QI being unable to descend normally, the stagnation of QI is not all right, and metabolite is constantly put aside, burnt in Yu Yu, strongly fragrant heat-transformation of a specified duration, pathogen usually intruding into collateral in protracted disease, cloudy blood consumption wound, weakness of the spleen and stomach, QI and blood scarcity, the deficiency of vital energy is difficult promoting the circulation of blood.

For the pathogeny of chronic atrophic gastritis, take benefiting qi and removing blood stasis as the rule for the treatment of, carry out dialectical composition of prescription, to reach the object for the treatment of both the principal and secondary aspects of a disease.

Summary of the invention

In order to overcome prior art Chinese patent medicine and the doctor trained in Western medicine deficiency undesirable to chronic atrophic gastritis therapeutic effect, the invention provides a kind ofly prepare conveniently, medicine source is wide, cost is low, the Chinese medicine composition of evident in efficacy, reliable effect, the treatment chronic atrophic gastritis that has no side effect.

The technical solution adopted for the present invention to solve the technical problems is: a kind of Chinese medicine composition for the treatment of chronic atrophic gastritis, is characterized in that: its raw material of Chinese medicine by following weight portion proportioning forms: 10～40 parts of Fructus Trichosanthis, 5～20 parts of the Rhizoma Pinelliaes, 3～15 parts of Rhizoma Coptidis, 5～25 parts of Fructus Aurantii Immaturuss, 5～20 parts, Poria, 5～25 parts of the Rhizoma Atractylodis Macrocephalaes, 5～20 parts of Fructus Toosendans, 3～15 parts of the Radix Aucklandiae, 5～25 parts of Radix Salviae Miltiorrhizaes, 3～15 parts of Fructus Amomis, 5～20 parts of Radix Angelicae Sinensis, 5～20 parts of Pollen Tyjphae, 3～10 parts, Radix Glycyrrhizae.

The preferred technical solution of the present invention is: a kind of Chinese medicine composition for the treatment of chronic atrophic gastritis, is characterized in that: its raw material of Chinese medicine by following weight portion proportioning forms: 30 parts of Fructus Trichosanthis, 12 parts of the Rhizoma Pinelliaes, 6 parts of Rhizoma Coptidis, 15 parts of Fructus Aurantii Immaturuss, 10 parts, Poria, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Fructus Toosendans, 6 parts of the Radix Aucklandiae, 15 parts of Radix Salviae Miltiorrhizaes, 6 parts of Fructus Amomis, 10 parts of Radix Angelicae Sinensis, 10 parts of Pollen Tyjphae, 6 parts, Radix Glycyrrhizae.

Chinese medicine composition of the present invention is under Traditional Chinese medical theory and clinical experience guidance, selected medicament composing prescription.In Chinese medicine composition of the present invention: Fructus Trichosanthis has clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, moisturizes effect of laxation; The Rhizoma Pinelliae has drying dampness to eliminate phlegm, effect of stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass; Rhizoma Coptidis has effect of heat clearing and damp drying, eliminating fire and detoxication; Fructus Aurantii Immaturus has effect of the loose painful abdominal mass of reducing phlegm, dispelling the stagnated QI removing food stagnancy; Poria has effect of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming; The Rhizoma Atractylodis Macrocephalae has effect of invigorating the spleen and benefiting QI, dampness diuretic; Fructus Toosendan have soothing the liverly expel the heat-evil, effect of promoting the circulation of QI to relieve pain, parasite killing; The Radix Aucklandiae has effect of intestinal stasis relieving in promoting the circulation of QI to relieve pain, tune; Radix Salviae Miltiorrhizae has effect of promoting blood flow to regulate menstruation, blood stasis dispelling eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind; Fructus Amomi has removing dampness appetizing, warming spleen and stopping diarrha, the antiabortive effect of regulating the flow of vital energy; Radix Angelicae Sinensis have enrich blood invigorate blood circulation, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation; Pollen Tyjphae has hemostasis, blood stasis dispelling, treating stranguria effect; Radix Glycyrrhizae has effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, coordinating the actions of various ingredients in a prescription.Drug component in the present composition is through dialectical compatibility, complement each other using, there is synergism, play altogether effect of spleen benefiting and stimulating the appetite, depressed liver-energy dispersing and QI regulating, removing dampness intestinal stasis relieving, clearing away heat and nourishing YIN, blood circulation promoting and blood stasis dispelling, chronic atrophic gastritis is reached to the object for the treatment of both the principal and secondary aspects of a disease.

The component of the present composition all adopts natural raw material of Chinese medicine, and its preparation is easy, medicine source is wide, cost is low.It follows the prescriptions principle of the traditional Chinese medical science, and various component drug adopt the use that is decocted in water for oral dose.Through clinical practice checking, it is evident in efficacy, reliable effect, and the property of medicine is gentle, does not occur toxic and side effects, total effective rate 93.7%, cure rate reaches 62.5%.

The specific embodiment

Below in conjunction with embodiment, the present invention will be further described.

Embodiment 1

Treat a Chinese medicine composition for chronic atrophic gastritis, its raw material of Chinese medicine by following weight proportion forms: Fructus Trichosanthis 30g, Rhizoma Pinelliae 12g, Rhizoma Coptidis 6g, Fructus Aurantii Immaturus 15g, Poria 10g, Rhizoma Atractylodis Macrocephalae 15g, Fructus Toosendan 10g, Radix Aucklandiae 6g, Radix Salviae Miltiorrhizae 15g, Fructus Amomi 6g, Radix Angelicae Sinensis 10g, Pollen Tyjphae 10g, Radix Glycyrrhizae 6g.

Embodiment 2

Treat a Chinese medicine composition for chronic atrophic gastritis, its raw material of Chinese medicine by following weight proportion forms: Fructus Trichosanthis 40g, Rhizoma Pinelliae 10g, Rhizoma Coptidis 3g, Fructus Aurantii Immaturus 20g, Poria 15g, Rhizoma Atractylodis Macrocephalae 5g, Fructus Toosendan 12g, Radix Aucklandiae 15g, Radix Salviae Miltiorrhizae 5g, Fructus Amomi 10g, Radix Angelicae Sinensis 20g, Pollen Tyjphae 8g, Radix Glycyrrhizae 10g.

Embodiment 3

Treat a Chinese medicine composition for chronic atrophic gastritis, its raw material of Chinese medicine by following weight proportion forms: Fructus Trichosanthis 20g, Rhizoma Pinelliae 15g, Rhizoma Coptidis 5g, Fructus Aurantii Immaturus 25g, Poria 5g, Rhizoma Atractylodis Macrocephalae 10g, Fructus Toosendan 20g, Radix Aucklandiae 3g, Radix Salviae Miltiorrhizae 10g, Fructus Amomi 15g, Radix Angelicae Sinensis 15g, Pollen Tyjphae 5g, Radix Glycyrrhizae 8g.

Embodiment 4

Treat a Chinese medicine composition for chronic atrophic gastritis, its raw material of Chinese medicine by following weight proportion forms: Fructus Trichosanthis 10g, Rhizoma Pinelliae 20g, Rhizoma Coptidis 15g, Fructus Aurantii Immaturus 5g, Poria 20g, Rhizoma Atractylodis Macrocephalae 25g, Fructus Toosendan 5g, Radix Aucklandiae 10g, Radix Salviae Miltiorrhizae 20g, Fructus Amomi 3g, Radix Angelicae Sinensis 8g, Pollen Tyjphae 12g, Radix Glycyrrhizae 5g.

Embodiment 5

Treat a Chinese medicine composition for chronic atrophic gastritis, its raw material of Chinese medicine by following weight proportion forms: Fructus Trichosanthis 25g, Rhizoma Pinelliae 5g, Rhizoma Coptidis 10g, Fructus Aurantii Immaturus 10g, Poria 12g, Rhizoma Atractylodis Macrocephalae 20g, Fructus Toosendan 15g, Radix Aucklandiae 12g, Radix Salviae Miltiorrhizae 25g, Fructus Amomi 8g, Radix Angelicae Sinensis 5g, Pollen Tyjphae 20g, Radix Glycyrrhizae 3g.

Chinese medicine composition in embodiment of the present invention decocting method is routinely produced medicament.Concrete grammar is as follows: the raw material of Chinese medicine of prescription is put into container, adds cold water and cover powder, soak 15～20 minutes, then add water and do not have approximately 8 centimetres of powder, decoct for the first time, adopt intense fire to decoct before at a simmer, after boiling with slow fire boiling 20～30 minutes; While decoction for the second time, add water and do not have approximately 6 centimetres of powder, after water boils, decoct 15～20 minutes.Twice decoction extracting juice that removes slag, merges.

Treat a Chinese medicine composition for chronic atrophic gastritis, clinical efficacy is summed up:

One, general data: this Chinese medicine composition is applied to observation 80 cases, male 48 examples, female's 32 examples, 24～80 years old age, the course of disease 2～10 years, wherein simple atrophy gastritis 65 examples, atrophic gastritis accompanied intestinal epithelial metaplasia 15 examples.

Two, diagnosis basis:

(1), gastral cavilty portion pain, often accompany the diseases such as the vexed or distension of painful abdominal mass, belch, pantothenic acid, noisy, nausea and vomiting;

(2), morbidity normal with feelings will not freely, eating and drinking without temperance, fatigue, the factor such as catch cold be relevant;

(3), upper digestive tract barium meal x-ray inspection, fibergastroscope and histopathology biopsy etc. are as auxiliary examination foundation.

Three, usage and dosage: when clinical practice, the amounts of components in compositions is taken the circumstances into consideration increase and decrease according to patient's body weight, age and symptom.Within seven days, be a course for the treatment of, one day potion, the about 400ml of twice extracting juice of decocting, point morning, late warm taking.

Four, efficacy evaluation:

(1), recovery from illness: clinical symptoms and sign disappear, and gastroscope shows that mucosa form is recovered or recovery substantially, and pathologic finding atrophic gastritis is changed into superficial gastritis, and intestinal epithelial metaplasia disappears;

(2), take a turn for the better: clinical symptoms and sign are clearly better, and gastroscope and pathologic finding show gastric mucosa atrophy, and inflammation, intestinal epithelial metaplasia degree alleviate;

(3), invalid: clinical symptoms and sign are not improved, and gastroscope and pathologic finding gastric mucosa are without change.

Four, therapeutic effect: in this clinical observation case, take medicine 2-20 the course for the treatment of, recovery from illness 50 examples, 25 examples that take a turn for the better, invalid 5 examples.During treatment, there is not toxic and side effects.

Five, model case:

Case 1:

Rectify certain, female, 56 years old.Gastralgia, accompanies heartburn, belch, acid regurgitation, happiness temperature aversion to cold, constipation to have more than half a year, is diagnosed as chronic atrophic gastritis through gastroscopy, companion's intestinal epithelial metaplasia.Take 4 courses for the treatment of of medicament prepared by Chinese medicine composition of the present invention, gastralgia obviously alleviates, heartburn, acid regurgitation is also good, and stool can day row.Change into superficial gastritis through gastroscope check diagnosis atrophic gastritis, intestinal epithelial metaplasia disappears.

Case 2:

Zhang, female, 60 years old.Medical private prosecution causes gastral cavilty portion uncomfortable 2 years without obvious inducement, accompany noisy, mild pain, time heartburn pantothenic acid.Be chronic atrophic gastritis through gastroscopy, companion's intestinal epithelial metaplasia.Take 5 courses for the treatment of of medicament prepared by Chinese medicine composition of the present invention, gastralgia malaise symptoms disappears, the not noisy pain of stomach, and check gastroscope is superficial gastritis, has no intestinal.

Claims

1. a Chinese medicine composition for the treatment of chronic atrophic gastritis, is characterized in that: its raw material of Chinese medicine and weight proportion are: Fructus Trichosanthis 30g, Rhizoma Pinelliae 12g, Rhizoma Coptidis 6g, Fructus Aurantii Immaturus 15g, Poria 10g, Rhizoma Atractylodis Macrocephalae 15g, Fructus Toosendan 10g, Radix Aucklandiae 6g, Radix Salviae Miltiorrhizae 15g, Fructus Amomi 6g, Radix Angelicae Sinensis 10g, Pollen Tyjphae 10g, Radix Glycyrrhizae 6g.