CN102940699A - Medicine composition for treating dyspepsia - Google Patents
Medicine composition for treating dyspepsia Download PDFInfo
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- CN102940699A CN102940699A CN2012104287660A CN201210428766A CN102940699A CN 102940699 A CN102940699 A CN 102940699A CN 2012104287660 A CN2012104287660 A CN 2012104287660A CN 201210428766 A CN201210428766 A CN 201210428766A CN 102940699 A CN102940699 A CN 102940699A
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- poria
- fructus
- radix glycyrrhizae
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- herba pogostemonis
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Abstract
The invention discloses a medicine composition for treating dyspepsia, comprising agastache rugosa, phyllanthus emblica, jujube, poria cocos and liquorice. The medicine composition disclosed herein can strengthen spleen and stomach, promote digestion, help digestion and stop diarrhea, and can treat abdominal discomfort or pain, meteorism, heartburn (sour regurgitation), no desire to sleep and eat, etc. caused by dyspepsia.
Description
Technical field
The present invention relates to a kind of dyspeptic pharmaceutical composition for the treatment of, specifically Herba Pogostemonis, Fructus Phyllanthi, Fructus Jujubae, Poria, Radix Glycyrrhizae are the pharmaceutical composition that raw material is made.
Background technology
Dyspepsia is a kind of common internal medicine digestive system disease, the morbidity crowd is many, its symptom main manifestations is for having by spells epigastric discomfort or pain, glutted, heartburn (acid regurgitation), belch, often be reluctant to take food or as far as possible few feed because of discomforts such as sense uncomfortable in chest, early full, abdominal distention, at night also be difficult to sleep peacefully, sleep rear often with nightmare.Also have some patient's abdominal distention obvious, the abdominal part borborygmus, aerofluxus increases, even the indigested food debris of Chang Kejian in the stool.
The Western medicine kind for the treatment of dyspepsia disease is numerous at present, such as motilium, metoclopramide etc., although instant effect, good effect, but certain side effect is arranged, Chinese medicine is little with its toxic and side effects, the occupancy volume of the market share enlarges year by year, but usually has the problems such as curative effect is rapid not, effective ingredient is not obvious, medication dose is large.
Summary of the invention
Purpose of the present invention just provides a kind of instant effect, and dosage is little, the dyspeptic pharmaceutical composition of the treatment that has no side effect.
The technical scheme that solution of the present invention adopts is: a kind ofly treating dyspeptic pharmaceutical composition, is that raw material forms by Herba Pogostemonis, Fructus Phyllanthi, Fructus Jujubae, Poria and Radix Glycyrrhizae.
Medicine of the present invention raw materials used weight proportion can be Herba Pogostemonis 5-20 part, Fructus Phyllanthi 1-18 part, Fructus Jujubae 1-20 part, Poria 1-15 part, Radix Glycyrrhizae 1-6 part.
The raw materials used optimum ratio of medicine of the present invention is: Herba Pogostemonis 5-18 part, Fructus Phyllanthi 5-15 part, Fructus Jujubae 5-18 part, Poria 1-12 part, Radix Glycyrrhizae 2-5 part.
The raw materials used more preferably proportioning of medicine of the present invention is: Herba Pogostemonis 10-14 part, Fructus Phyllanthi 8-10 part, Fructus Jujubae 10-14 part, Poria 5-7 part, Radix Glycyrrhizae 3-4 part.
The raw materials used best proportioning of medicine of the present invention is: 12 parts of Herba Pogostemoniss, 9 parts of Fructus Phyllanthis, 12 parts in Fructus Jujubae, 6 parts in Poria, 3 parts in Radix Glycyrrhizae.
The dosage form of medicine of the present invention can be any existing pharmaceutical dosage form in drop pill, tablet, capsule, soft capsule, the granule.
Pharmaceutical composition of the present invention can adopt but be not limited to following methods:
(1) gets the Herba Pogostemonis medical material, add 55 ℃ of lixiviates of ethanol of 75% 3 times of 8-10 times of volume, each 1.5 hours.Collect merge extractive liquid, and concentrated, drying gets Herba Pogostemonis extract.
(2) get the Fructus Phyllanthi medical material, the water reflux, extract, of 8-12 times of volume of adding 10 hours is collected extracting solution, and concentrated, drying gets Fructus Phyllanthi extract.
(3) get the Fructus Jujubae medical material by formula proportion, with the 60-95% alcohol reflux of 8-10 times of volume 3 times, each 1.5h, extracting liquid filtering, merging filtrate, concentrating under reduced pressure, drying gets Fructus Jujubae extract.
(4) get the Poria medical material, the decocting that adds 8-12 times of volume boiled 2 hours, again added the water of 8 times of volumes of water behind the collection solution, decocted 1 hour, filtered merging filtrate.Extracting solution after merging is joined in the dual-effect concentrator, be concentrated into relative density 1.13-1.17g/mL.Concentrated solution is changed in the Alcohol-settling tank, add 75% ethanol and make pure content reach 40%.Supernatant behind the precipitate with ethanol is changed in the single-action concentration tank, and Recycled ethanol reaches 1.24-1.28g/ml to the extracting solution relative density, and the vacuum drying extracting solution namely gets Poria extract.
(5) extracting liquorice medical material adds the water boiling and extraction 2 times of 8-10 times of volume, each 1.5-2h, and merge extractive liquid,, concentrated, dry, get Radix Glycyrrhizae extract.
(6) above-mentioned Herba Pogostemonis, Fructus Phyllanthi, Fructus Jujubae, Poria and Radix Glycyrrhizae extract are mixed, make acceptable various pharmaceutical dosage form.
The used various raw medicinal materials of the present invention are the Chinese crude drug that meets country or provincial standard regulation.
In the pharmaceutical composition of the present invention, Herba Pogostemonis acrid in the mouth, slightly warm in nature.Return spleen, stomach, lung meridian.Removing dampness by means of aromatics, stomach function regulating preventing or arresting vomiting, dispelling summer-heat from superficies of the body.Cure mainly: gastral cavity abdomen painful abdominal mass Min of main retention of dampness in middle-JIAO; Inappetence; Vomiting; Have loose bowels; The cold and heat headache of diseases caused by exogenous pathogenic factor heat-damp in summer; Hygropyrexia from the beginning of the heating body be stranded; Feel sick in breast Min; Nasal sinusitis; Tinea manus and pedis.
The Fructus Phyllanthi bitter but sweet flavor, cold in nature.Attach to the lung and stomach meridians.Relieving sore-throat by clearing away heat, moistening the lung and resolving phlegm, promoting the production of body fluid to quench thirst." Traditional Chinese Medicine in Sichuan will ": " enter spleen, the stomach paralysis is reduced phlegm, and promotes the production of body fluid cough-relieving, detoxifcation.The heating that cures cold, cough pharyngalgia, diphtheria, restlessness and fever with thirst.”
The Fructus Jujubae sweet in the mouth, warm in nature.Return spleen, stomach, heart channel.Invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.Be used for insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.
Poria sweet in the mouth, light, property is flat.GUIXIN warp, lung meridian, spleen channel, kidney channel.Function: diuretic medicine; Diuretics with the action of eliminating dampness.Cure mainly: dysuria; The edema distension; The phlegm retention cough with dyspnea; Vomiting; Insufficiency of the spleen lack of appetite; Have loose bowels; Palpitation and restlessness; Insomnia forgetfulness; The seminal emission nebulousurine.
The Radix Glycyrrhizae nature and flavor are sweet, flat, and GUIXIN, lung, spleen, stomach warp have the QI invigorating invigorating middle warmer, the function of heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the mediation property of medicine.
The used various raw medicinal materials of the present invention are the Chinese crude drug that meets country or provincial standard regulation.The dyspeptic pharmaceutical composition for the treatment of of the present invention, as the basis take theory of Chinese medical science, in conjunction with clinical practice, from Chinese medicine material treasure-house, filter out have invigorating the stomach and promoting digestion, invigorating the spleen and benefiting QI, regulating QI to relieve pain, digestive pure purification of tcm form, but latent heat in the clearing stomach, let out the fire of liver taste, transfer the liver QI of the spleen and stomach, the symptoms such as the abdominal discomfort that causes for the treatment dyspepsia or pain, glutted, heartburn (acid regurgitation), belch have good curative effect.
The specific embodiment
The present invention is described in further detail below in conjunction with the specific embodiment.
Embodiment 1
The dyspeptic pharmaceutical composition of the treatment that the present embodiment is enumerated is comprised of the medicinal raw material of following weight: Herba Pogostemonis 12g, Fructus Phyllanthi 9g, Fructus Jujubae 12g, Poria 6g, Radix Glycyrrhizae 3g.
Above-mentioned medicinal raw material is prepared into soft capsule, and preparation method is as follows:
(1) gets the Herba Pogostemonis medical material by embodiment 1 formula proportion, add 55 ℃ of lixiviates of ethanol of 75% 3 times of 8 times of volumes, each 1.5 hours.Collect merge extractive liquid, and concentrated, drying gets Herba Pogostemonis extract.
(2) get the Fructus Phyllanthi medical material by embodiment 1 formula proportion, the water reflux, extract, of 10 times of volumes of adding 10 hours is collected extracting solution, and concentrated, drying gets Fructus Phyllanthi extract.
(3) get the Fructus Jujubae medical material by embodiment 1 formula proportion, with 80% alcohol reflux of 10 times of volumes 3 times, each 1.5h, extracting liquid filtering, merging filtrate, concentrating under reduced pressure, drying gets Fructus Jujubae extract.
(4) get the Poria medical material by embodiment 1 formula proportion, the decocting that adds 10 times of volumes boiled 2 hours, again added the water of 8 times of volumes of water behind the collection solution, decocted 1 hour, filtered merging filtrate.Extracting solution after merging is joined in the dual-effect concentrator, be concentrated into relative density 1.13-1.17g/ml.Concentrated solution is changed in the Alcohol-settling tank, add 75% ethanol and make pure content reach 40%.Supernatant behind the precipitate with ethanol is changed in the single-action concentration tank, and Recycled ethanol reaches 1.24-1.28g/ml to the extracting solution relative density, and the vacuum drying extracting solution namely gets Poria extract.
(5) press embodiment 1 formula proportion extracting liquorice medical material, add the water boiling and extraction 2 times of 10 times of volumes, each 1.5h, merge extractive liquid,, concentrated, dry, get Radix Glycyrrhizae extract.
(6) above-mentioned Herba Pogostemonis, Fructus Phyllanthi, Fructus Jujubae, Poria, Radix Glycyrrhizae extract are mixed.
(7) with said mixture and vegetable oil 25g, mixing is made capsule casing material with gelatin, adopts existing soft capsule preparation technology, is pressed into soft capsule.
Embodiment 2
The dyspeptic pharmaceutical composition of the treatment that the present embodiment is enumerated is comprised of the medicinal raw material of following weight: Herba Pogostemonis 20g, Fructus Phyllanthi 10g, Fructus Jujubae 18g, Poria 10g, Radix Glycyrrhizae 5g.
Above-mentioned medicinal raw material is prepared into tablet, and preparation method is as follows:
(1) gets the Herba Pogostemonis medical material by embodiment 2 formula proportion, add 55 ℃ of lixiviates of ethanol of 75% 3 times of 8 times of volumes, each 1.5 hours.Collect merge extractive liquid, and concentrated, drying gets Herba Pogostemonis extract.
(2) get the Fructus Phyllanthi medical material by embodiment 2 formula proportion, the water reflux, extract, of 10 times of volumes of adding 10 hours is collected extracting solution, and concentrated, drying gets Fructus Phyllanthi extract.
(3) get the Fructus Jujubae medical material by embodiment 2 formula proportion, with 80% alcohol reflux of 10 times of volumes 3 times, each 1.5h, extracting liquid filtering, merging filtrate, concentrating under reduced pressure, drying gets Fructus Jujubae extract.
(4) get the Poria medical material by embodiment 2 formula proportion, the decocting that adds 10 times of volumes boiled 2 hours, again added the water of 8 times of volumes of water behind the collection solution, decocted 1 hour, filtered merging filtrate.Extracting solution after merging is joined in the dual-effect concentrator, be concentrated into relative density 1.13-1.17g/ml.Concentrated solution is changed in the Alcohol-settling tank, add 75% ethanol and make pure content reach 40%.Supernatant behind the precipitate with ethanol is changed in the single-action concentration tank, and Recycled ethanol reaches 1.24-1.28g/ml to the extracting solution relative density, and the vacuum drying extracting solution namely gets Poria extract.
(5) press embodiment 2 formula proportion extracting liquorice medical materials, add the water boiling and extraction 2 times of 10 times of volumes, each 1.5h, merge extractive liquid,, concentrated, dry, get Radix Glycyrrhizae extract.
(6) above-mentioned Herba Pogostemonis, Fructus Phyllanthi, Fructus Jujubae, Poria, Radix Glycyrrhizae extract are mixed.
(7) with said mixture and 100g starch, the 20g polyvidone mixes, and adopts existing pressed-disc technique, makes tablet.
Embodiment 3
The dyspeptic pharmaceutical composition of the treatment that the present embodiment is enumerated is comprised of the medicinal raw material of following weight: Herba Pogostemonis 6g, Fructus Phyllanthi 3g, Fructus Jujubae 2g, Poria 6g, Radix Glycyrrhizae 1g.
Above-mentioned medicinal raw material is prepared into capsule, and preparation method is as follows:
(1) gets the Herba Pogostemonis medical material by embodiment 3 formula proportion, add 55 ℃ of lixiviates of ethanol of 75% 3 times of 10 times of volumes, each 1.5 hours.Collect merge extractive liquid, and concentrated, drying gets Herba Pogostemonis extract.
(2) get the Fructus Phyllanthi medical material by embodiment 3 formula proportion, the water reflux, extract, of 10 times of volumes of adding 10 hours is collected extracting solution, and concentrated, drying gets Fructus Phyllanthi extract.
(3) get the Fructus Jujubae medical material by embodiment 3 formula proportion, with 80% alcohol reflux of 8 times of volumes 3 times, each 1.5h, extracting liquid filtering, merging filtrate, concentrating under reduced pressure, drying gets Fructus Jujubae extract.
(4) get the Poria medical material by embodiment 3 formula proportion, the decocting that adds 10 times of volumes boiled 2 hours, again added the water of 8 times of volumes of water behind the collection solution, decocted 1 hour, filtered merging filtrate.Extracting solution after merging is joined in the dual-effect concentrator, be concentrated into relative density 1.13-1.17g/ml.Concentrated solution is changed in the Alcohol-settling tank, add 75% ethanol and make pure content reach 40%.Supernatant behind the precipitate with ethanol is changed in the single-action concentration tank, and Recycled ethanol reaches 1.24-1.28g/ml to the extracting solution relative density, and the vacuum drying extracting solution namely gets Poria extract.
(5) press embodiment 3 formula proportion extracting liquorice medical materials, add the water boiling and extraction 2 times of 8 times of volumes, each 1.5h, merge extractive liquid,, concentrated, dry, get Radix Glycyrrhizae extract.
(6) above-mentioned Herba Pogostemonis, Fructus Phyllanthi, Fructus Jujubae, Poria, Radix Glycyrrhizae extract are mixed.
(7) with said mixture and starch 100g mix homogeneously, adopt capsules preparation technique, make the pharmaceutical composition of capsule.
The curative effect of medicine of the present invention and advantage thereof are proved by following clinical trial:
1, experiment crowd:
Be divided into A, B, three experimental grouies of C by disease symptom:
2, drug administration method:
The dyspeptic medicine for the treatment of that the oral embodiment of the invention 1 makes, every day is early, middle and late respectively to take 2 after the meal, serve on 5 days.
3, efficacy evaluation:
Symptom is invalid without alleviation or DeGrain; Symptom disappears substantially or complete obiteration is effectively.
4, therapeutic effect:
。
Claims (4)
1. treat dyspeptic pharmaceutical composition for one kind, it is characterized in that: the medicament that it is mainly made by the raw material of following weight parts proportioning:
Herba Pogostemonis 5-20 part, Fructus Phyllanthi 1-18 part, Fructus Jujubae 1-20 part, Poria 1-15 part, Radix Glycyrrhizae 1-6 part.
2. pharmaceutical composition according to claim 1, it is characterized in that: the weight portion proportioning of described each crude drug is:
Herba Pogostemonis 5-18 part, Fructus Phyllanthi 5-15 part, Fructus Jujubae 5-18 part, Poria 1-12 part, Radix Glycyrrhizae 2-5 part.
3. pharmaceutical composition according to claim 2, it is characterized in that: the weight portion proportioning of described each crude drug is:
Herba Pogostemonis 10-14 part, Fructus Phyllanthi 8-10 part, Fructus Jujubae 10-14 part, Poria 5-7 part, Radix Glycyrrhizae 3-4 part.
4. pharmaceutical composition according to claim 3, it is characterized in that: the weight portion proportioning of described each crude drug is:
12 parts of Herba Pogostemoniss, 9 parts of Fructus Phyllanthis, 12 parts in Fructus Jujubae, 6 parts in Poria, 3 parts in Radix Glycyrrhizae.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104398956A (en) * | 2014-11-06 | 2015-03-11 | 成都果睿医药科技有限公司 | Pharmaceutical composition for treating dyspepsia |
| CN104398957A (en) * | 2014-11-06 | 2015-03-11 | 成都果睿医药科技有限公司 | Pharmaceutical composition for treating dyspepsia |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04169533A (en) * | 1990-10-29 | 1992-06-17 | Shintoku Rin | Medicine and food composition |
| KR20070000594A (en) * | 2005-06-28 | 2007-01-03 | (주)함소아 | Method for preparing kyungohkgo with enhanced texture and taste, and kyungohkgo prepared thereby |
| CN1903334A (en) * | 2006-07-28 | 2007-01-31 | 解备卿 | Traditional Chinese medicine prepn. for preventing infantile respiratory tract infection repeatedly and treating hypopepsia |
| AU2007100050A4 (en) * | 2007-01-19 | 2007-02-15 | G & W Aust Pty Ltd | Herbal compositions and uses for vitality-boosting in aging and sub-optimal health |
| CN101069551A (en) * | 2007-06-15 | 2007-11-14 | 胡耀辉 | Method for preparing ageratum and elsholtzia type roasting jam |
| CN101613652A (en) * | 2009-07-31 | 2009-12-30 | 湖北美公生物科技有限公司 | Tuckahoe health care white spirit and preparation method thereof |
| WO2012137223A1 (en) * | 2011-04-04 | 2012-10-11 | Mahakul Jogi | A synergistic herbal extract composition for use in treating bloating |
-
2012
- 2012-10-31 CN CN201210428766.0A patent/CN102940699B/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04169533A (en) * | 1990-10-29 | 1992-06-17 | Shintoku Rin | Medicine and food composition |
| KR20070000594A (en) * | 2005-06-28 | 2007-01-03 | (주)함소아 | Method for preparing kyungohkgo with enhanced texture and taste, and kyungohkgo prepared thereby |
| CN1903334A (en) * | 2006-07-28 | 2007-01-31 | 解备卿 | Traditional Chinese medicine prepn. for preventing infantile respiratory tract infection repeatedly and treating hypopepsia |
| AU2007100050A4 (en) * | 2007-01-19 | 2007-02-15 | G & W Aust Pty Ltd | Herbal compositions and uses for vitality-boosting in aging and sub-optimal health |
| CN101069551A (en) * | 2007-06-15 | 2007-11-14 | 胡耀辉 | Method for preparing ageratum and elsholtzia type roasting jam |
| CN101613652A (en) * | 2009-07-31 | 2009-12-30 | 湖北美公生物科技有限公司 | Tuckahoe health care white spirit and preparation method thereof |
| WO2012137223A1 (en) * | 2011-04-04 | 2012-10-11 | Mahakul Jogi | A synergistic herbal extract composition for use in treating bloating |
Non-Patent Citations (1)
| Title |
|---|
| 崔同寅: "《中药调剂指南》", 30 April 1998, 中国中医药出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104398956A (en) * | 2014-11-06 | 2015-03-11 | 成都果睿医药科技有限公司 | Pharmaceutical composition for treating dyspepsia |
| CN104398957A (en) * | 2014-11-06 | 2015-03-11 | 成都果睿医药科技有限公司 | Pharmaceutical composition for treating dyspepsia |
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| CN102940699B (en) | 2014-04-23 |
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