CN102940583B - Thermosensitive hydrogel capable of being used as nutrition mask and preparation method of thermosensitive hydrogel - Google Patents
Thermosensitive hydrogel capable of being used as nutrition mask and preparation method of thermosensitive hydrogel Download PDFInfo
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- CN102940583B CN102940583B CN201210485804.6A CN201210485804A CN102940583B CN 102940583 B CN102940583 B CN 102940583B CN 201210485804 A CN201210485804 A CN 201210485804A CN 102940583 B CN102940583 B CN 102940583B
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Abstract
The invention provides a thermosensitive hydrogel capable of being used as a nutrition mask and a preparation method of the thermosensitive hydrogel and belongs to the field of natural polymer material biological application. According to the thermosensitive hydrogel, good-biocompatibility natural polymer materials of agar, gelatin, sodium carboxymethylcellulose, chitosan, derivatives of the chitosan, alginic acid, derivatives of the aloginic acid, collagen, hyaluronic acid, derivatives of the hyaluronic acid, glycerol and the like are used as hydrogel raw materials, proportionally dissolved in water, stirred to form a uniform solution or an emulsion, poured into a mask mold, and then placed in a 60Co-gamma industrial irradiation device to be irradiated with the adsorbed dose of 5kGy-60kGy to synthesize the thermosensitive hydrogel. The preparation method is simple, heating is not required, and the raw materials are not required to be specially treated before irradiation. The thermosensitive hydrogel is good in biocompatibility, water-soluble skin nutrition materials can be accordingly released, and good skin care effects are achieved.
Description
Technical field
The present invention relates to a kind of temperature-sensitive hydrogel that can be used as nourishing pack and preparation method thereof, is the synthetic hydrogel of natural macromolecular material, belongs to natural macromolecular material cosmetic applications field.
Background technology
At present, the beauty mask of market popularity is mainly taking non-woven fabrics, paper, cotton as base material, flood facial mask liquid and form, can directly use, when use, direct docile is in health a part, along with the osmosis of facial mask liquid, contained facial mask liquid acts on people's skin, promotes cutaneous circulation, strengthens epidermis cell vigor, moisten and skin nutrition, reach the effect that improves skin quality.But with non-woven fabrics, paper, cotton etc. be face mask substrate material, except playing carrier function, do not possess beauty functions.Because the base material adsorptivities such as non-woven fabrics, paper, cotton are not strong, in facial film, liquid content is not high.Meanwhile, contained facial mask liquid is easily fixed by base material, cannot all act on skin surface, and these base materials also exist and not docile, the problem such as uncomfortable of contact skin, causes this class facial film to be worth not high.
Hydrogel is that some high polymers or copolymer absorb the semisolid that large quantity of moisture, swell cross form, and has good physicochemical property and biological property.Hydrogel has good hydrophilic, has very strong swelling ability in water, but water insoluble.Hydrogel is in use located solvent swelling state, quite soft, and has caoutchouc elasticity, can reduce the machinery of peripheral cell and tissue is collided and stimulated, simultaneously to skin without adhesion, tear off without sense of discomfort, can be used as the raw material of desirable human body skin nursing.
Existing hydrogel preparation method mostly is chemical synthesis, and need under higher temperature, add cross-linking agent could synthetic water gel.But there is toxicity to human body and environment in conventional a lot of cross-linking agent.In hydrogel material choice, natural macromolecular material because of its good biocompatibility, wide material sources, can regenerate in a large number, can be by bacterial degradation, be difficult for causing the good characteristics such as white pollution to become study hotspot, but most natural macromolecular materials, as the chemical crosslinking such as polysaccharide, protide difficulty, are difficult to the synthetic stable cosmetic water gel of character.Synthetic polymer, because activity is strong, is easy to synthetic water gel under cross-linking agent effect, therefore multiselect synthetic polymer is hydrogel raw material, but synthetic polymer is toxic to human body and environment greatly, easily to human body and environment and injury.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of temperature-sensitive hydrogel that can be used as nourishing pack.
The technical problem to be solved in the present invention is to provide a kind of preparation method of the temperature-sensitive hydrogel that can be used as nourishing pack.
A kind of temperature-sensitive hydrogel that can be used as nourishing pack of the present invention, is characterized in that said composition is composed of the following components by weight percentage:
Agar 0%～15%
Gelatin 2%～20%
Sodium carboxymethyl cellulose 1%～15%
Chitosan and derivant 0.1%～5% thereof
Alginic acid and derivant 0%～20% thereof
Collagen protein 0.01%～10%
Hyaluronic acid and derivant 0.01%～5% thereof
Other natural macromolecular materials 0%～6%
Glycerol 0%～4%
All the other are water.
Described chitosan and derivant thereof are chitosan or using carboxyl chitosan.
Described alginic acid and derivant thereof are alginic acid, potassium alginate or sodium alginate.
Described alginic acid and derivant thereof are sodium alginate.
Described hyaluronic acid and derivant thereof are hyaluronic acid, hyaluronate sodium, Curiosin or calcium hyauronate.
Described hyaluronic acid and derivant thereof are hyaluronic acid or hyaluronate sodium.
Described other natural macromolecular materials are carrageenan, cyclodextrin or Rhizoma amorphophalli powder.
The preparation method of a kind of temperature-sensitive hydrogel that can be used as nourishing pack of the present invention, comprises the following steps successively:
(a) according to raw material composition and ratio by soluble in water to agar, gelatin, sodium carboxymethyl cellulose and derivant thereof, chitosan and derivant thereof, alginic acid and derivant thereof, collagen protein, hyaluronic acid and derivant thereof, glycerol, other natural macromolecular materials, stir, make homogeneous solution or emulsion;
(b) homogeneous solution of preparation or emulsion are filled with in cosmetics mould to encapsulated moulding; Put into
60in Co-γ industrial irradiation device, be under 5kGy～60kGy, to carry out irradiation, crosslinked synthetic water gel in absorbed dose.
Above-mentioned hydrogel feedstock composition, each component requires good water solubility.
In above-mentioned hydrogel feedstock composition, preferred chitosan and derivant thereof are selected from chitosan or using carboxyl chitosan.
In above-mentioned hydrogel feedstock composition, preferred alginic acid and derivant thereof are selected from alginic acid, potassium alginate or sodium alginate, wherein sodium alginate most preferably.
In above-mentioned hydrogel feedstock composition, hyaluronic acid and derivant thereof are selected from hyaluronic acid, hyaluronate sodium, Curiosin and calcium hyauronate.Wherein most preferably hyaluronic acid or hyaluronate sodium.
In above-mentioned hydrogel feedstock composition, preferably other natural macromolecular materials are carrageenan, cyclodextrin or Rhizoma amorphophalli powder.
A kind of temperature-sensitive hydrogel that can be used as nourishing pack of the present invention, with nontoxic, harmless, good biocompatibility, natural macromolecular material natural macromolecular material agar, gelatin, sodium carboxymethyl cellulose, chitosan and derivant, alginic acid and the derivant thereof with certain health care, skin-protecting function, collagen protein, hyaluronate sodium, glycerol, other natural macromolecular materials etc. as hydrogel raw material, irradiation synthetic water gel.This class hydrogel not only itself possesses good skin nursing effect, also has strong absorbability, can absorb moisture and load the more beautifying nourishing factor, and then being prepared into the multiclass product of the comprehensive restoration care of human body skin.Hydrogel provided by the invention is temperature-sensitive hydrogel, and in 10 DEG C～50 DEG C temperature ranges, such hydrogel is along with temperature raises, and its water suction saturation reduces, and moisture disengages from gel inside.Like this, the nutritional labeling in film, except acting on skin by the osmosis of film itself, can also be disengaged along with disengaging of moisture, and then acts on skin, has improved greatly the utilization rate of nutritional labeling, has played good skin care effect.
Preparation method utilization of the present invention
60co-gamma-rays effect synthetic water gel, synthesis and preparation process is simple, is easy to suitability for industrialized production.
60co-gamma-rays has strong penetrance, and preparative capacibility is strong,, when crosslinked synthetic water gel, can, to the hydrogel sterilizing that carries out disinfection, be the hydrogel synthetic method of a kind of safety, environmental protection.
Beneficial effect of the present invention has:
(a) such hydrogel synthesis technique is simple, strong operability, and energy consumption is low.Predose, raw material only need stir at normal temperatures, does not need extra other to process, and irradiation process does not need to do heat treated.
(b) synthetic hydrogel stable performance, the environmental change such as temperature, humidity in building-up process is minimum to the performance impact of hydrogel, also can not affect its combined coefficient and properties of product in the time that temperature is low.
(c) in preparation process, radiation sterilization completes together with crosslinked synthesizing.Because
60co-γ irradiation sterilization method is the sterilizing methods of existing very ripe, safety non-pollution, in synthetic water gel, has also completed the sterilization of hydrogel.
(d) hydrogel building-up process
60it is crosslinked that Co-gamma-rays causes hydrogel raw material, do not need to add any cross-linking agent, further reduced the impact of poisonous and harmful compound.
(e) raw material of selecting and synthesis technique are not introduced poisonous and harmful substance, and synthetic hydrogel good biocompatibility, is beneficial to environment sustainable development.
Brief description of the drawings
Fig. 1 is the photo of application examples of the present invention;
Fig. 2 is the photo of further application of the invention example.
Detailed description of the invention
Embodiment 1
Under room temperature and normal pressure, click respectively in table 1 each component of specifying gelatin, sodium carboxymethyl cellulose, using carboxyl chitosan, collagen protein is soluble in water, stir and form homogeneous solution or emulsion, according to needing, the mould of preparation difformity, different-thickness.Material solution is poured in mould, and encapsulated moulding, puts into radiation chamber irradiation 15 kGy～60 kGy, synthetic water gel.
Fig. 1 is the photo of application examples of the present invention, and a kind of temperature-sensitive hydrogel that can be used as nourishing pack prepared by the present invention sticks on photo on hand, and it is round that this hydrogel is made mould, and thickness is 3mm.
Fig. 2 is the photo of further application of the invention example.A kind of temperature-sensitive hydrogel that can be used as nourishing pack prepared by the present invention sticks on photo on hand.
Embodiment 2
Repeat the method for embodiment 1 by each constituent content of the appointment in following table 1, but selected component and weight content difference thereof.
Embodiment 3
Repeat the method for embodiment 1 by each constituent content of the appointment in following table 1, but selected component and weight content difference thereof.
Embodiment 4
Repeat the method for embodiment 1 by each constituent content of the appointment in following table 1, but selected component and weight content difference thereof.
Embodiment 5
Repeat the method for embodiment 1 by each constituent content of the appointment in following table 1, but selected component and weight content difference thereof.
Embodiment 6
Repeat the method for embodiment 1 by each constituent content of the appointment in following table 1, but selected component and weight content difference thereof.
Embodiment 7
Repeat the method for embodiment 1 by each constituent content of the appointment in following table 1, but selected component and weight content difference thereof.
Embodiment 8
Repeat the method for embodiment 1 by each constituent content of the appointment in following table 1, but selected component and weight content difference thereof.
Table 1
| Each constituent content (weight portion) and heavy metal adsorption | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | Embodiment 7 | Embodiment 8 |
| Agar | 1% | 2% | 0.3% | 0.3% | ||||
| Gelatin | 3% | 3.5% | 6% | 4% | 10% | 15% | 8% | 11% |
| Sodium carboxymethyl cellulose | 1.5% | 0.3% | 10% | 3% | 2% | 4% | 1% | |
| Chitosan and derivant thereof | 1% | 0.2% | 4% | 3% | 1% | |||
| Alginic acid and derivant thereof | 0.6% | 0.1% | 1% | 2% | 6% | |||
| Collagen protein | 0.1% | 0.1% | 0.2% | 0.2% | 0.2% | 2% | ||
| Hyaluronic acid and derivant thereof | 1% | 4% | 3% | 1% | 2% | |||
| Other natural macromolecular materials | 1% | 0.2% | 1% | |||||
| Glycerol | 0.1% | 0.2% | 0.01% |
Claims (2)
1. as a temperature-sensitive hydrogel for nourishing pack, it is characterized in that said composition is made up of following component by weight percentage:
Agar 0%～15%
Gelatin 2%～20%
Sodium carboxymethyl cellulose 1%～15%
Chitosan and derivant 0.1%～5% thereof
Alginic acid and derivant 0%～20% thereof
Collagen protein 0.01%～10%
Hyaluronic acid and derivant 0.01%～5% thereof
Other natural macromolecular materials 0%～6%
Glycerol 0%～4%
All the other are water;
Described chitosan and derivant thereof are chitosan or using carboxyl chitosan;
Described alginic acid and derivant thereof are alginic acid, potassium alginate or sodium alginate;
Described hyaluronic acid and derivant thereof are hyaluronic acid, hyaluronate sodium, Curiosin or calcium hyauronate;
Described other natural macromolecular materials are carrageenan, cyclodextrin or Rhizoma amorphophalli powder;
Temperature-sensitive hydrogel as nourishing pack is made by the preparation method comprising the following steps:
(a) according to raw material composition and ratio by soluble in water to agar, gelatin, sodium carboxymethyl cellulose, chitosan and derivant thereof, alginic acid and derivant thereof, collagen protein, hyaluronic acid and derivant thereof, glycerol, other natural macromolecular materials, stir, make homogeneous solution or emulsion;
(b) homogeneous solution of preparation or emulsion are filled with in cosmetics mould to encapsulated moulding; Put into
60in Co-γ industrial irradiation device, be under 5kGy～60kGy, to carry out irradiation, crosslinked synthetic water gel in absorbed dose.
2. the temperature-sensitive hydrogel as nourishing pack according to claim 1, is characterized in that: described alginic acid and derivant thereof are sodium alginate.
3. the temperature-sensitive hydrogel as nourishing pack according to claim 1, is characterized in that: described hyaluronic acid and derivant thereof are hyaluronic acid or hyaluronate sodium.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210485804.6A CN102940583B (en) | 2012-11-26 | 2012-11-26 | Thermosensitive hydrogel capable of being used as nutrition mask and preparation method of thermosensitive hydrogel |
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| CN201210485804.6A CN102940583B (en) | 2012-11-26 | 2012-11-26 | Thermosensitive hydrogel capable of being used as nutrition mask and preparation method of thermosensitive hydrogel |
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| CN102940583A CN102940583A (en) | 2013-02-27 |
| CN102940583B true CN102940583B (en) | 2014-10-08 |
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Inventor after: Yang Guixia Inventor after: Li Xiaoyan Inventor after: Wu Xiaoli Inventor after: An You Inventor after: Liu Xuqiang Inventor after: Yu Xiangzhong Inventor after: Zeng Fansong Inventor after: Pang Yuanlong Inventor after: Huang Wei Inventor after: Li Zongjun Inventor after: Jiang Shubin Inventor before: Yang Guixia Inventor before: Li Xiaoyan Inventor before: Wu Xiaoli Inventor before: An You Inventor before: Liu Xuqiang Inventor before: Yu Xiangzhong Inventor before: Zeng Fansong Inventor before: Pang Yuanlong Inventor before: Huang Wei Inventor before: Li Zongjun Inventor before: Jiang Shubin |
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