CN102940548A - Device for continuous low-temperature lung surface cooling of no-heart heating donor - Google Patents
Device for continuous low-temperature lung surface cooling of no-heart heating donor Download PDFInfo
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- CN102940548A CN102940548A CN2012104026980A CN201210402698A CN102940548A CN 102940548 A CN102940548 A CN 102940548A CN 2012104026980 A CN2012104026980 A CN 2012104026980A CN 201210402698 A CN201210402698 A CN 201210402698A CN 102940548 A CN102940548 A CN 102940548A
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Abstract
The invention belongs to the technical field of assistant medical devices, and specifically provides a device for continuous low-temperature lung surface cooling of a no-heart heating donor. The device provided by the invention comprises a circulating water tank, a cold air blower, a circulating water temperature controller, a water pump, a semiconductor cooling module, a reversing valve, a peristaltic pump, a lung preservation solution container, a blowing circulating water pipe heat exchanger, an inlet and an outlet, which are connected with one another through pipelines. The device provided by the invention is the device used for filling low-temperature lung preservation solution into the chest before opening the chest to take the lung. The device has the advantages of automation in operation, high cooling speed and controllable temperature range, and can fill the low-temperature lung preservation solution into the chest, cool the lung surface continuously at low temperature and resist against no-heart heating donor lung ischemia injury.
Description
Technical field
The invention belongs to medical assistance device technology field, be specifically related to a kind of being applied in the transplanting of Lungs from Non-Heart-Beating donor lung, the preservation of in-situ low-temperature lung the surface-cooled device of lungs consecutive low temperature lung.
Background technology
Latter stage at end, unique effective Therapeutic Method of pulmonary disease was lung transplant.Clinical lung transplant operation quantity increases less at present, stagnation, main cause is that the brain death donor (has the heart beating donor, heart heating donor, HBD) critical shortage, therefore numerous scholars invest sight the research of Lungs from Non-Heart-Beating donor (non heart heating donor, NHBD).Yet there is the heartbeat blood supply in HBD, and the NHBD donor is opposite, and there is Warm ischemia injury in various degree in the acardia blood supply, As time goes on and gradually loses function, is not suitable for carrying out lung transplant again.Warm ischemia injury time length determines the quality for the lung quality, and cooling, the shortening heat Ischemia Time of carrying out as early as possible lungs is requisite measures that lungs are preserved.In clinical lung was transplanted, low temperature was one of important measures of preserving in internal organs, can reduce cellular metabolism, and enzymatic activity and energy consumption are slowed down cell death, was the necessary component that organ is preserved.The classical mode that employing is soaked through the cold protection liquid merging of lung vascular perfusion low temperature can reach the rapid cooling of HBD donor lung the effect of cryopreservation.In NHBD, because Ethical factors, before authorizing, family members can not get lung exsomatize hypothermia perfusion, immersion by traditional breast of opening, can only be Wicresoft, non-stripped state, we are referred to as in-situ low-temperature lung store method.Opening before breast gets lung; at present adopt the intrathoracic pipe of Wicresoft to pour into cold protection liquid for lung in-situ low-temperature lung Techniques of preserving in the external clinical NHBD lung transplantation more, carry out the lungs surface cool, cooling that can fast speed; alleviate Warm ischemia injury, obtained confirmation.But technique adopts manual operations, wastes time and energy, and cooling rate is subjected to external temperature influence larger, use inconvenience, demand a kind of automation mechanized operation urgently, simple and convenient, the device that cooling rate is very fast, temperature range is controlled is realized the perfusion of low temperature lung preserving liquid in the thoracic cavity, improves for the lung quality.
Summary of the invention
The object of the present invention is to provide a kind of automation mechanized operation, simple and convenient, cooling rate is very fast, temperature range is controlled is applied to the surface-cooled device of Lungs from Non-Heart-Beating donor consecutive low temperature lung, to realize the perfusion of low temperature lung preserving liquid in the thoracic cavity, consecutive low temperature carries out the lungs surface cool.
The surface-cooled device of Lungs from Non-Heart-Beating donor consecutive low temperature lung that is applied to provided by the invention, its structure specifically comprises as shown in Figure 1: cyclic water tank 1, cold blowing blower fan 2, circulating water temperature controller 3, water pump 4, semiconductor refrigerating module 5, reversal valve 6, peristaltic pump 7, lungs are preserved liquid container 8, blow circulating water pipe heat exchanger 9, inflow entrance 10, flow export 11; Wherein:
Lungs are preserved liquid container 8 and are used for depositing lungs and preserve liquid, and peristaltic pump 7 is connected to lungs and preserves a side of liquid container 8 (being the left side among Fig. 1), mobilely provide the power support for what lungs were preserved liquid; Peristaltic pump 7 connects the hot junction of semiconductor refrigerating module 5 by pipeline, semiconductor refrigerating module 5 is preserved liquid for the lungs that flow and proposed the processing of lowering the temperature; The cold junction of semiconductor refrigerating module 5 is preserved between liquid container 8 opposite sides (being the right side among Fig. 1) with lungs and is connected by pipeline, reversal valve 6 is set on this pipeline, this reversal valve 6 connects inflow entrances 10, the switching of reversal valve 6 so that the flow direction lungs preserve liquid container 8 or flow to inflow entrance 10; The described opposite side (being the right side among Fig. 1) of preserving liquid container 8 at the lungs lungs also connects flow export 11; Wherein inflow entrance 10 provides the low temperature lungs to preserve pouring into of liquid by the thoracic cavity of device for cleaning pipeline toward Lungs from Non-Heart-Beating donor lungs, and flow export 11 is drawn from the thoracic cavity of Lungs from Non-Heart-Beating donor lungs, preserves the outflow of liquid for lungs in the thoracic cavity, flows to lungs and preserves liquid container 8.
Semiconductor refrigerating module 5 connects water-cooled and wind-cooling heat dissipating system, its objective is that the heat that the semiconductor refrigerating module is produced leaves, so that the running of semiconductor refrigerating module consecutive low temperature is preserved the cooling that liquid continues to the lungs in quasiconductor refrigeration module 5, reversal valve 6, peristaltic pump 7, the flow direction cyclic water tank 8.Described water-cooled and wind-cooling heat dissipating system are constructed as follows: connect successively circulating water temperature controller 3 and water pump 4 in the left side of cyclic water tank 1; Cyclic water tank 1 provides cold water source, and circulating water temperature controller 3 and water pump 4 provide respectively the adjustable control of temperature and the power support that cold water flows; Blow circulating water pipe heat exchanger 9 in the connection of the right side of cyclic water tank 1, carry out exchange heat, heat is discharged; Blow circulating water pipe heat exchanger 9 and connect cold blowing blower fan 2 by pipeline, in order to accelerate heat radiation.
Compared with prior art, the surface-cooled device of Lungs from Non-Heart-Beating donor consecutive low temperature lung that is applied to provided by the invention, a kind ofly to open breast and be used for before getting lung the device of perfusion low temperature lung preserving liquid in the thoracic cavity, possess operation automation, cooling rate is very fast, temperature range is controlled advantage, can realize the perfusion of low temperature lung preserving liquid in the thoracic cavity, consecutive low temperature carries out the lungs surface cool, and the antagonism Lungs from Non-Heart-Beating is for the lung-heat ischemic injuries.
Description of drawings
Fig. 1 is apparatus of the present invention structural diagrams.
Number in the figure: 1 is cyclic water tank, and 2 are the cold blowing blower fan, and 3 is the circulating water temperature controller, and 4 is water pump, 5 is the semiconductor refrigerating module, and 6 is reversal valve, and 7 is peristaltic pump, and 8 are lungs preservation liquid container, 9 for blowing the circulating water pipe heat exchanger, and 10 is inflow entrance, and 11 is flow export.
The specific embodiment
Apparatus of the present invention are taken away heat so that low temperature Lung protection liquid flows through continuously and healthily the thoracic cavity, reach the surface-cooled purpose of lungs, the antagonism Warm ischemia injury.This technical scheme is expected to Lungs from Non-Heart-Beating donor lung original position is implemented fast cooling, farthest protects clinical transplantation to use the lung source.
Further set forth the present invention below in conjunction with accompanying drawing:
Fig. 1 is the structural diagrams of apparatus of the present invention.The workflow of apparatus of the present invention is:
1, lungs are preserved and are filled with lungs preservation liquid in the liquid container 8, switch to liquid cold cycle stream state (without inflow entrance 10 and flow export 11 thoracic cavity of namely not flowing through) by reversal valve 6, open semiconductor refrigerating module 5 and peristaltic pump 7, the circular treatment so that lungs preservation liquid is lowered the temperature in semiconductor refrigerating module 5, reversal valve 6, peristaltic pump 7, flow direction cyclic water tank 8.
2, treat that liquid reaches predetermined temperature in the lungs preservation liquid container 8, and in the time of need to carrying out cooling off in the thoracic cavity to Lungs from Non-Heart-Beating donor lungs, reversal valve 6 switches to the thoracic cavity state of cooling (through inflow entrance 10 and flow export 11 thoracic cavity of namely flowing through), just can carry out fast cooling to the lung surface, take away the lungs heat.
3, the low temperature lungs are preserved liquid and after entering the thoracic cavity through inflow entrance 10 lungs are produced cooling effect, take away simultaneously heat, cause lungs to preserve the rise of temperature of liquid.The liquid of temperature recovery is got back to cyclic water tank 8 by flow export 11, again flow in the semiconductor refrigerating module 5 by peristaltic pump 7, the processing of lowering the temperature, and then process inflow entrance 10 enters into the thoracic cavity, the circulation of formation consecutive low temperature reduces Lungs from Non-Heart-Beating donor lungs surface temperature effectively.
4, semiconductor refrigerating module 5 itself can be taken away the heat that lungs are preserved liquid when refrigeration is provided, and finally distributing by water-cooled and wind-cooling heat dissipating facility of these heats finished.Cyclic water tank 1 provides the circulating water source, water pump 4 provides power, circulating water temperature controller 3 carries out temperature adjusting, so that circulating water flows to semiconductor refrigerating module 5, take away lungs and preserve the heat that contains in the liquid, carry out exchange heat in blowing circulating water pipe heat exchanger 9, heat is discharged, cold blowing blower fan 2 can accelerate heat radiation.
Claims (1)
1. one kind is applied to the surface-cooled device of Lungs from Non-Heart-Beating donor consecutive low temperature lung, it is characterized in that: by cyclic water tank (1), cold blowing blower fan (2), circulating water temperature controller (3), water pump (4), semiconductor refrigerating module (5), reversal valve (6), peristaltic pump (7), lungs preserve liquid container (8), blow circulating water pipe heat exchanger (9), inflow entrance (10), flow export (11) connect to form by the road; Wherein:
Lungs are preserved liquid containers (8) and are used for depositing lungs and preserve liquid, and peristaltic pump (7) is connected to the side that lungs are preserved liquid containers (8), mobilely provide the power support for what lungs were preserved liquid; Peristaltic pump (7) connects the hot junction of semiconductor refrigerating module (5) by pipeline, semiconductor refrigerating module (5) is preserved liquid for the lungs that flow and proposed the processing of lowering the temperature; The cold junction of semiconductor refrigerating module (5) is preserved between liquid container (8) opposite side with lungs and is connected by pipeline, reversal valve (6) is set on this pipeline, this reversal valve (6) connects inflow entrance (10), the switching of reversal valve (6) so that the flow direction lungs preserve liquid container (8) or flow to inflow entrance (10); The described opposite side of preserving liquid container (8) at the lungs lungs also connects flow export (11); Wherein inflow entrance (10) is by the thoracic cavity of device for cleaning pipeline toward Lungs from Non-Heart-Beating donor lungs, provide the low temperature lungs to preserve pouring into of liquid, flow export (11) is drawn from the thoracic cavity of Lungs from Non-Heart-Beating donor lungs, preserves the outflow of liquid for lungs in the thoracic cavity, flows to lungs and preserves liquid container (8);
Semiconductor refrigerating module (5) connects water-cooled and wind-cooling heat dissipating system, and described water-cooled and wind-cooling heat dissipating system comprise: connect successively circulating water temperature controller (3) and water pump (4) in the left side of cyclic water tank (1); Cyclic water tank (1) provides cold water source, and circulating water temperature controller (3) and water pump (4) provide respectively the adjustable control of temperature and the power support that cold water flows; Right side at cyclic water tank (1) connects circulating water pipe heat exchanger (9), carries out exchange heat, and heat is discharged; Circulating water pipe heat exchanger (9) connects cold blowing blower fan (2) by pipeline, in order to accelerate heat radiation.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104026980A CN102940548A (en) | 2012-10-22 | 2012-10-22 | Device for continuous low-temperature lung surface cooling of no-heart heating donor |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012104026980A CN102940548A (en) | 2012-10-22 | 2012-10-22 | Device for continuous low-temperature lung surface cooling of no-heart heating donor |
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| CN102940548A true CN102940548A (en) | 2013-02-27 |
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| CN2012104026980A Pending CN102940548A (en) | 2012-10-22 | 2012-10-22 | Device for continuous low-temperature lung surface cooling of no-heart heating donor |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108489179A (en) * | 2018-03-27 | 2018-09-04 | 北京华信佳音医疗科技发展有限责任公司 | A kind of human body temperature-controlling system and device |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1130347A (en) * | 1994-07-12 | 1996-09-04 | 伊莱亚斯有限公司 | Method to refrigerate a jacket for keeping a transplant organ cold |
| JP2001104362A (en) * | 1999-10-13 | 2001-04-17 | Yukio Kuniyoshi | Sinus node cooling device and heart beat restraint system using it |
| US20070162097A9 (en) * | 2004-03-16 | 2007-07-12 | Rojas Arturo R | Patient cooling system and method |
| US20110040359A1 (en) * | 2007-09-27 | 2011-02-17 | Harris Steve B | Portable apparatus and method for the administration of heat exchange in the lungs of a mammal |
| CN202908927U (en) * | 2012-10-22 | 2013-05-01 | 同济大学附属上海市肺科医院 | Device applied to continuous low-temperature lung surface cooling of non heart heating donor |
-
2012
- 2012-10-22 CN CN2012104026980A patent/CN102940548A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1130347A (en) * | 1994-07-12 | 1996-09-04 | 伊莱亚斯有限公司 | Method to refrigerate a jacket for keeping a transplant organ cold |
| JP2001104362A (en) * | 1999-10-13 | 2001-04-17 | Yukio Kuniyoshi | Sinus node cooling device and heart beat restraint system using it |
| US20070162097A9 (en) * | 2004-03-16 | 2007-07-12 | Rojas Arturo R | Patient cooling system and method |
| US20110040359A1 (en) * | 2007-09-27 | 2011-02-17 | Harris Steve B | Portable apparatus and method for the administration of heat exchange in the lungs of a mammal |
| CN202908927U (en) * | 2012-10-22 | 2013-05-01 | 同济大学附属上海市肺科医院 | Device applied to continuous low-temperature lung surface cooling of non heart heating donor |
Non-Patent Citations (2)
| Title |
|---|
| STIG STEEN, TRYGVE SJOBERG, LEIF PIERRE, ET AL.: "Transplantation of lungs from a non-heart-beating donor", 《THE LANCET》 * |
| 彭富裕，胥义，赵晓刚，等.: "无心跳供体肺原位降温保护***的研究", 《制冷学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108489179A (en) * | 2018-03-27 | 2018-09-04 | 北京华信佳音医疗科技发展有限责任公司 | A kind of human body temperature-controlling system and device |
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Application publication date: 20130227 |