CN102927787B - The apparatus and method of quick-frozen blood plasma - Google Patents
The apparatus and method of quick-frozen blood plasma Download PDFInfo
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- CN102927787B CN102927787B CN201110226681.XA CN201110226681A CN102927787B CN 102927787 B CN102927787 B CN 102927787B CN 201110226681 A CN201110226681 A CN 201110226681A CN 102927787 B CN102927787 B CN 102927787B
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- refrigeration
- liquid refrigerant
- canister
- module
- blood plasma
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Abstract
The invention discloses a kind of apparatus and method of quick-frozen blood plasma.Described device comprises: refrigeration shell, the liquid refrigerant being built in the canister in refrigeration shell and being put in canister, wherein: described liquid refrigerant is liquid ethanol or dimethyl sulfoxide (DMSO).Technical scheme of the present invention can realize frozen plasma rapidly.
Description
Technical field
The present invention relates to the technical field preparing refrigerated plasma, particularly relate to a kind of apparatus and method of quick-frozen blood plasma.
Background technology
Human plasma is commonly used to replace whole blood to export to the wounded or patient, with timely replenishment of blood content as Blood Preparations.
The current blood plasma for Clinical practice has refrigerated plasma, and refrigerated plasma can the seasoning several years.
The preparation process of conventional refrigerated plasma is that packed blood plasma is directly put into refrigerator or refrigerator-freezer, freezes to be shaped after a few hours.Such as packed blood plasma is directly put into the refrigerator-freezer of-30 DEG C (degrees Celsius), general 12 hours that need could fully charge.
But the scheme of above-mentioned direct employing refrigerator or refrigerator-freezer frozen plasma, it is long that its blood plasma freezes the required time, is unfavorable for integrality and the stability of guaranteeing various active ingredient and active material in blood plasma.
Summary of the invention
The invention provides a kind of device of quick-frozen blood plasma, utilize a kind of method of the method for this device quick-frozen blood plasma and quick-frozen blood plasma.Technical scheme of the present invention can realize frozen plasma rapidly.
For achieving the above object, technical scheme of the present invention is achieved in that
The invention discloses a kind of device of quick-frozen blood plasma, this device comprises: refrigeration shell, the liquid refrigerant being built in the canister in refrigeration shell and being put in canister, wherein:
Described liquid refrigerant is liquid ethanol or dimethyl sulfoxide (DMSO).
In said apparatus, described refrigeration shell comprises: control module, power module, refrigeration module and display panels;
Control module, sends cooling signals for the control instruction inputted according to user to refrigeration module;
Refrigeration module, freezes for the cooling signals sent according to control module;
Display panels, for the cryogenic temperature of display translation refrigeration module;
Power module, for providing power supply for control module, refrigeration module and display panels.
In said apparatus, described canister is aluminium vessel or stainless steel container.
In said apparatus, described canister comprises: multiple cancellate sub-container, and often a sub-container has the lid of oneself.
In said apparatus, described multiple cancellate sub-container layer distributed is in refrigeration shell.
In said apparatus, described refrigeration shell and canister are the inseparable structures be integrally formed.
The invention also discloses and a kind ofly utilize above-mentioned device to carry out the method for quick-frozen to blood plasma, the method comprises:
Refrigeration shell is utilized to carry out precooling to the liquid refrigerant in canister;
When liquid refrigerant reaches predetermined low temperature, packed blood plasma is put into liquid refrigerant and carries out quick-frozen.
The invention also discloses a kind of method of quick-frozen blood plasma, the method comprises:
Precooling treatment is carried out to liquid refrigerant, makes the low temperature that the temperature of liquid refrigerant reaches predetermined; Wherein, described liquid refrigerant is liquid ethanol or dimethyl sulfoxide (DMSO);
Packed blood plasma is put into liquid refrigerant.
In the above-mentioned methods, describedly precooling treatment is carried out to liquid refrigerant comprise: liquid refrigerant is put into canister, then canister is put into refrigerator, refrigerator-freezer or specific refrigerating plant and carry out precooling.
In the above-mentioned methods, described canister is aluminium vessel or stainless steel container.
From above-mentioned, the present invention is this carries out precooling treatment to liquid refrigerant, make the low temperature that the temperature of liquid refrigerant reaches predetermined, wherein, described liquid refrigerant is liquid ethanol or dimethyl sulfoxide (DMSO), then packed blood plasma is put into the technical scheme that liquid refrigerant carries out fast frozen, owing to make use of liquid ethanol or dimethyl sulfoxide (DMSO) as liquid refrigerant, therefore, it is possible to make packed blood plasma can freeze rapidly to be shaped, thus guarantee integrality and the stability of various active ingredient and active material in blood plasma.
Accompanying drawing explanation
Fig. 1 is the structural representation of the device of a kind of quick-frozen blood plasma in the present invention;
Fig. 2 is the composition structural representation of the refrigeration shell in the present invention;
Fig. 3 is another structural representation of the canister in the present invention;
Fig. 4 is the flow chart of the method for a kind of quick-frozen blood plasma in the embodiment of the present invention.
Detailed description of the invention
In order to make the object, technical solutions and advantages of the present invention clearly, describe the present invention below in conjunction with the drawings and specific embodiments.
Fig. 1 is the structural representation of the device of a kind of quick-frozen blood plasma in the present invention.As shown in Figure 1, this device comprises: refrigeration shell 101, the liquid refrigerant 103 being built in the canister 102 in refrigeration shell 101 and being put in canister.Wherein, liquid refrigerant 103 can be liquid ethanol, or is liquid dimethyl sulfoxide (DMSO) (DMSO).In inventive embodiments, liquid ethanol and liquid dimethyl sulfoxide (DMSO) can be all the aqueous solution of certain purity, also can be the liquid of 100% purity.
In Fig. 1 shown device, refrigeration shell 101 is the refrigerating plants being similar to refrigerator or refrigerator-freezer etc., and canister 102 is the containers for contain fluid cold-producing medium.In use, first utilize refrigeration shell to carry out precooling to the liquid refrigerant in canister, when liquid refrigerant reaches certain low temperature, packed blood plasma is put into liquid refrigerant and carries out quick-frozen.Here canister can be heat transfer aluminium vessel or stainless steel container faster.
In the present invention, what liquid ethanol and liquid dimethyl sulfoxide (DMSO) adopted is the ethanol water or dimethyl sulphoxide aqueous solution that purity is higher, its concentration its freezing point higher is lower, still can keep liquid when carrying out precooling, such as, the freezing point of the ethanol water of 70% is-48 DEG C, and concentration is that the freezing point of the dimethyl sulphoxide aqueous solution of 60% can be down to-80 DEG C.The concentration of ethanol water or dimethyl sulphoxide aqueous solution can be selected according to actual conditions.
Fig. 2 is the composition structural representation of the refrigeration shell in the present invention.As shown in Figure 2, the refrigeration shell 101 shown in Fig. 1 comprises: control module 201, power module 202, refrigeration module 203 and display panels 204; Wherein:
Control module 201, sends cooling signals for the control instruction inputted according to user to refrigeration module 203;
Refrigeration module 203, freezes for the cooling signals sent according to control module 201;
Display panels 204, for the cryogenic temperature of display translation refrigeration module 203;
Power module 202, for providing power supply for control module 201, refrigeration module 203 and display panels 204.
In other embodiments of the invention, described canister 102 can also comprise: multiple cancellate sub-container, and wherein every individual sub-container has the lid of oneself.Fig. 3 is another structural representation of the canister in the present invention.As shown in Figure 3, this canister is made up of multiple cancellate sub-container.Described multiple cancellate sub-container layer distributed, in refrigeration shell, in order to show multiple sub-container, does not draw the lid of sub-container here.
In one embodiment of the invention, the refrigeration shell 101 shown in Fig. 1 and canister 102 can be the inseparable structures be integrally formed.
Fig. 4 is the flow chart of the method for a kind of quick-frozen blood plasma in the embodiment of the present invention.As shown in Figure 4, the method comprises:
Step 401, carries out precooling treatment to liquid refrigerant, makes the low temperature that the temperature of liquid refrigerant reaches predetermined; Wherein, described liquid refrigerant is liquid ethanol or dimethyl sulfoxide (DMSO).
In this step, liquid refrigerant is put into canister, the refrigerating plant then canister being put into refrigerator, refrigerator-freezer or feature carries out precooling.Canister can be aluminium vessel or stainless steel container.
Step 402, puts into liquid refrigerant by packed blood plasma.After waiting for the shorter time, blood plasma can freeze to be shaped.
In technical scheme of the present invention, creatively using liquid ethanol and dimethyl sulfoxide (DMSO) as liquid refrigerant, for refrigerated plasma, packed blood plasma is directly directly put into refrigerator or refrigerator-freezer carries out freezing scheme relative to traditional by this, can greatly shorten blood plasma freeze to be shaped needed for time.To this, applicant has carried out the quick-frozen test of raw blood plasma in certain blood station:
Adopt aluminium vessel to load liquid ethanol, and put into refrigerator-freezer and carry out precooling, when ethanol temperature reaches-35 DEG C, put into the raw blood plasma 14 bags of first 600ml/ bag, take out after 20 minutes, now ethanol temperature is-12 DEG C, and raw blood plasma is down to about 0 DEG C from body temperature.First raw blood plasma is proceeded to other refrigerator-freezers preserve, and in the ethanol in refrigerator-freezer, put into the raw blood plasma 14 bags of second batch 600ml/ bag, take out after 30 minutes, now ethanol temperature is 4 DEG C, raw blood plasma is also down to about 0 DEG C from body temperature, and quick-frozen effect is also fine.
In order to as a comparison, equally the raw blood plasma 10 bags of the 600ml/ bag of collection is directly put into the refrigerator-freezer of-30 DEG C, result blood plasma needs 12 hours ability fully charges.
From above-mentioned test, during with cold ethanol as cold-producing medium, blood plasma clearly, can freeze to be shaped by quick-frozen effect in a short period of time.
Also precooling treatment has been carried out to the liquid ethanol as cold-producing medium in the present invention, this measure further shorten blood plasma freeze be shaped needed for time.Table 1 is respectively using the cold ethanol after precooling treatment and the normal temperature ethanol result of the test as cold-producing medium:
Table 1
As can be seen from Table 1, precooling treatment is carried out to liquid ethanol, after making its temperature reach subzero two, 30 degree, can blood plasma be made more rapidly to freeze.
In sum, the present invention is this carries out precooling treatment to liquid refrigerant, make the low temperature that the temperature of liquid refrigerant reaches predetermined, wherein, described liquid refrigerant is liquid ethanol or dimethyl sulfoxide (DMSO), then packed blood plasma is put into the technical scheme that liquid refrigerant carries out fast frozen, owing to make use of liquid ethanol or dimethyl sulfoxide (DMSO) as liquid refrigerant, therefore, it is possible to make packed blood plasma can freeze rapidly to be shaped, thus guarantee integrality and the stability of various active ingredient and active material in blood plasma.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment made, equivalent replacement, improvement etc., all should be included within the scope of protection of the invention.
Claims (3)
1. a device for quick-frozen blood plasma, is characterized in that, this device comprises: refrigeration shell, the liquid refrigerant being built in the canister in refrigeration shell and being put in canister, wherein:
Described liquid refrigerant is liquid ethanol or dimethyl sulfoxide (DMSO);
Described canister comprises multiple cancellate sub-container, and often a sub-container has the lid of oneself;
Described multiple cancellate sub-container layer distributed is in refrigeration shell;
Described canister is aluminium vessel or stainless steel container;
Described refrigeration shell and canister are the inseparable structures be integrally formed;
Described refrigeration shell comprises: control module, power module, refrigeration module and display panels;
Control module, sends cooling signals for the control instruction inputted according to user to refrigeration module;
Refrigeration module, freezes for the cooling signals sent according to control module;
Display panels, for the cryogenic temperature of display translation refrigeration module;
Power module, for providing power supply for control module, refrigeration module and display panels.
2. utilize the device described in claim 1 blood plasma to be carried out to a method for quick-frozen, it is characterized in that, the method comprises:
Refrigeration shell is utilized to carry out precooling to the liquid refrigerant in canister;
When liquid refrigerant reaches predetermined low temperature, packed blood plasma is put into liquid refrigerant and carries out quick-frozen.
3. a method for quick-frozen blood plasma, is characterized in that, the method comprises:
Precooling treatment is carried out to liquid refrigerant, makes the low temperature that the temperature of liquid refrigerant reaches predetermined; Wherein, described liquid refrigerant is liquid ethanol or dimethyl sulfoxide (DMSO);
Packed blood plasma is put into liquid refrigerant;
Describedly precooling treatment is carried out to liquid refrigerant comprise: liquid refrigerant is put into canister, then canister is put into refrigerator, refrigerator-freezer or specific refrigerating plant and carry out precooling; Wherein, described canister comprises multiple cancellate sub-container, and often a sub-container has the lid of oneself;
Described multiple cancellate sub-container layer distributed is in refrigeration shell;
Described canister is aluminium vessel or stainless steel container;
Described refrigeration shell and canister are the inseparable structures be integrally formed;
Described refrigeration shell comprises: control module, power module, refrigeration module and display panels;
Control module, sends cooling signals for the control instruction inputted according to user to refrigeration module;
Refrigeration module, freezes for the cooling signals sent according to control module;
Display panels, for the cryogenic temperature of display translation refrigeration module;
Power module, for providing power supply for control module, refrigeration module and display panels.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110226681.XA CN102927787B (en) | 2011-08-09 | 2011-08-09 | The apparatus and method of quick-frozen blood plasma |
| HK13104607.2A HK1177492A1 (en) | 2011-08-09 | 2013-04-16 | Device and method for quick-freezing blood plasma |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110226681.XA CN102927787B (en) | 2011-08-09 | 2011-08-09 | The apparatus and method of quick-frozen blood plasma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102927787A CN102927787A (en) | 2013-02-13 |
| CN102927787B true CN102927787B (en) | 2015-08-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110226681.XA Expired - Fee Related CN102927787B (en) | 2011-08-09 | 2011-08-09 | The apparatus and method of quick-frozen blood plasma |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN102927787B (en) |
| HK (1) | HK1177492A1 (en) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993013372A1 (en) * | 1991-12-24 | 1993-07-08 | Kensett, John, Hinton | Apparatus for cooling or chilling beverage containers |
| US5408845A (en) * | 1993-09-08 | 1995-04-25 | Microchill Int Ltd | Cooling or chilling apparatus |
| JP2005192533A (en) * | 2004-01-09 | 2005-07-21 | Technican:Kk | Method and device for rapidly freezing food by liquid surface contact |
| CN201637214U (en) * | 2010-04-12 | 2010-11-17 | 贾富忠 | Plasma quick-freezing device |
| CN202209844U (en) * | 2011-08-09 | 2012-05-02 | 马建川 | Device quickly freezing blood plasma |
-
2011
- 2011-08-09 CN CN201110226681.XA patent/CN102927787B/en not_active Expired - Fee Related
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2013
- 2013-04-16 HK HK13104607.2A patent/HK1177492A1/en not_active IP Right Cessation
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| Publication number | Publication date |
|---|---|
| HK1177492A1 (en) | 2013-08-23 |
| CN102927787A (en) | 2013-02-13 |
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