CN102920876A - External Chinese medicinal composition for treating knee osteoarthritis - Google Patents
External Chinese medicinal composition for treating knee osteoarthritis Download PDFInfo
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- CN102920876A CN102920876A CN2012104980160A CN201210498016A CN102920876A CN 102920876 A CN102920876 A CN 102920876A CN 2012104980160 A CN2012104980160 A CN 2012104980160A CN 201210498016 A CN201210498016 A CN 201210498016A CN 102920876 A CN102920876 A CN 102920876A
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- 239000000203 mixture Substances 0.000 title claims abstract description 13
- 208000003947 Knee Osteoarthritis Diseases 0.000 title abstract description 6
- 201000008482 osteoarthritis Diseases 0.000 title abstract description 6
- 239000003814 drug Substances 0.000 claims abstract description 16
- 241001180876 Saposhnikovia Species 0.000 claims abstract description 6
- 241001506304 Kadsura japonica Species 0.000 claims abstract 2
- 210000000629 knee joint Anatomy 0.000 claims description 28
- 206010003246 arthritis Diseases 0.000 claims description 12
- 241001604597 Pyrestini Species 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 8
- 239000009286 sanguis draxonis Substances 0.000 claims description 8
- 229940079593 drug Drugs 0.000 claims description 7
- 230000000694 effects Effects 0.000 abstract description 12
- 210000003734 kidney Anatomy 0.000 abstract description 4
- 210000004185 liver Anatomy 0.000 abstract description 3
- 210000002784 stomach Anatomy 0.000 abstract description 3
- 230000004936 stimulating effect Effects 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 235000002566 Capsicum Nutrition 0.000 abstract 1
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 1
- 241000218671 Ephedra Species 0.000 abstract 1
- 244000223060 Erythrina herbacea Species 0.000 abstract 1
- 235000005280 Erythrina herbacea Nutrition 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 239000006002 Pepper Substances 0.000 abstract 1
- 235000016761 Piper aduncum Nutrition 0.000 abstract 1
- 235000017804 Piper guineense Nutrition 0.000 abstract 1
- 244000203593 Piper nigrum Species 0.000 abstract 1
- 235000008184 Piper nigrum Nutrition 0.000 abstract 1
- 239000009136 dragon's blood Substances 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 1
- 235000011477 liquorice Nutrition 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 description 15
- 239000004744 fabric Substances 0.000 description 12
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 8
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 6
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 241001506371 Kadsura Species 0.000 description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 4
- 229910052782 aluminium Inorganic materials 0.000 description 4
- 229910052742 iron Inorganic materials 0.000 description 4
- 238000012856 packing Methods 0.000 description 4
- 238000000746 purification Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 206010023232 Joint swelling Diseases 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 210000003127 knee Anatomy 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 206010002027 Amyotrophy Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 206010005963 Bone formation increased Diseases 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010065564 Floating patella Diseases 0.000 description 1
- 206010017577 Gait disturbance Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
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- 238000005481 NMR spectroscopy Methods 0.000 description 1
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- 210000004204 blood vessel Anatomy 0.000 description 1
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- 230000035602 clotting Effects 0.000 description 1
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- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000005065 subchondral bone plate Anatomy 0.000 description 1
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- 230000008736 traumatic injury Effects 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the field of Chinese medicaments, and in particular relates to an external Chinese medicinal composition for treating knee osteoarthritis. The external Chinese medicinal composition is prepared from cassia twig, divaricate saposhnikovia root, dragon blood, caulis sinomenii, kadsura pepper stem, oriental variegated coralbean bark, ephedra and liquorice. The external Chinese medicinal composition is low in cost, simple in prescription, reasonable and effective in component compatibility and convenient to use, prevents the medicament from stimulating stomach and intestinal tracts and damaging liver and kidney, does not have toxic or side effect to a human body, and has remarkable curative effect in treating knee osteoarthritis.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate in particular to a kind of Traditional Chinese Medicine for external application compositions for the treatment of knee joint osseous arthritis.
Background technology
Knee joint osseous arthritis is that kneed degenerative becomes, and belongs to the category of the traditional Chinese medical science " rheumatism involving the bone ".Pathogenesis belongs to that strain cold is attacked, wet poly-blood clotting, phlegm and blood stasis, the blood vessels stasis of blood stagnate, qi depression to blood stasis, impatency meridians, stagnation of QI and blood may bring about pain, swollen, joint stuffiness then.Pathogeny is summarised as constitutional and suffers from a deficiency of the kidney and the Secondary cases blood stasis.This disease is relevant with factors such as age, chronic strain, obesity, heredity, endocrine regulation, inflammation, dysbolismus.Multiple knee joint one side of being born in of knee joint osseous arthritis also may be fallen ill the knee joint both sides simultaneously.According to the document statistics, the knee osteoarthritis person is suffered from the whole nation at present 9,000 ten thousand people.Account for below 45 years old and account for 80% more than 5%, 75 years old, as seen this sick multiple crowd who is born between 50-60 years old.
The primary disease sickness rate is very high, and modern medicine can carry out joint replacement surgery, but most people not wish accept and can't bear the huge cost of operation.Chinese medicine and western medicine is at present without the method for radically treating, and medicine mostly is oral medicine, causes damage when stimulating stomach, intestinal and to Liver and kidney, and toxic and side effects is larger.
Summary of the invention
The Traditional Chinese Medicine for external application compositions that the purpose of this invention is to provide a kind of evident in efficacy and treatment knee joint osseous arthritis of having no side effect.
For solving the problems of the technologies described above, the technical solution used in the present invention is as follows:
A kind of Traditional Chinese Medicine for external application compositions for the treatment of knee joint osseous arthritis is to be made by the raw material of following weight portion: Ramulus Cinnamomi 10-25 part, Radix Saposhnikoviae 5-20 part, Sanguis Draxonis 15-30 part, Caulis Sinomenii 15-30 part, Caulis Piperis Kadsurae 15-30 part, Cortex erythrinae 15-30 part, Herba Ephedrae 5-20 part and Radix Glycyrrhizae 5-10 part.
Described a kind of Traditional Chinese Medicine for external application compositions for the treatment of knee joint osseous arthritis, preferred weight part of its raw material is: 7 parts in 18 parts of Ramulus Cinnamomi, 15 parts of Radix Saposhnikoviaes, 25 parts of Sanguis Draxonis, 20 parts of Caulis Sinomeniis, 18 parts of Caulis Piperis Kadsuraes, 23 parts of Cortex erythrinaes, 15 parts in Herba Ephedrae and Radix Glycyrrhizae.
Below be the pharmacology analysis of this Chinese medicine composition component:
Herba Ephedrae, Ramulus Cinnamomi, Radix Saposhnikoviae: Xin Wen disperses, energy cold-dispelling damp, temperature three-way meridian, alleviating pain.Sanguis Draxonis: the promoting blood circulation to remove blood stasis pain relieving is used for the treatment of traumatic injury and swells and ache.Caulis Sinomenii, Caulis Piperis Kadsurae, Cortex erythrinae: wind-damp dispelling, removing obstruction in the collateral to relieve pain.The compositions curative effect: dispel the wind, cold expelling, invigorate blood circulation, collateral dredging, pain relieving.
With the raw material of the described weight proportion cloth bag of packing into, place iron pan or aluminum pot, boil 30-40 minute after, pull cloth bag out, squeeze water purification, be placed on while hot the knee joint site of disease, keeping the cloth bag temperature is 40-45 ℃, external application 20-30 minute, a twice-daily, midfeather 5-6 hour.
The present invention compared with prior art has following advantage: with low cost, prescription is simple, and the component collocation rationally effectively, easy to use, avoided medicine to the stimulation of stomach, intestinal with to the infringement of Liver and kidney, without any side effects to human body, treatment knee joint osseous arthritis evident in efficacy.
The specific embodiment
Embodiment 1
Get 5 parts in 10 parts of Ramulus Cinnamomi, 5 parts of Radix Saposhnikoviaes, 15 parts of Sanguis Draxonis, 15 parts of Caulis Sinomeniis, 15 parts of Caulis Piperis Kadsuraes, 15 parts of Cortex erythrinaes, 5 parts in Herba Ephedrae and Radix Glycyrrhizae.With the raw material of the above-mentioned weight proportion cloth bag of packing into, place iron pan or aluminum pot, boil 30-40 minute after, pull cloth bag out, squeeze water purification, be placed on while hot the knee joint site of disease, keeping the cloth bag temperature is 40-45 ℃, external application 20-30 minute, a twice-daily, midfeather 5-6 hour.
Embodiment 2
Get 10 parts in 25 parts of Ramulus Cinnamomi, 20 parts of Radix Saposhnikoviaes, 30 parts of Sanguis Draxonis, 30 parts of Caulis Sinomeniis, 30 parts of Caulis Piperis Kadsuraes, 30 parts of Cortex erythrinaes, 20 parts in Herba Ephedrae and Radix Glycyrrhizae.With the raw material of the above-mentioned weight proportion cloth bag of packing into, place iron pan or aluminum pot, boil 30-40 minute after, pull cloth bag out, squeeze water purification, be placed on while hot the knee joint site of disease, keeping the cloth bag temperature is 40-45 ℃, external application 20-30 minute, a twice-daily, midfeather 5-6 hour.
Embodiment 3
Get 7 parts in 18 parts of Ramulus Cinnamomi, 15 parts of Radix Saposhnikoviaes, 25 parts of Sanguis Draxonis, 20 parts of Caulis Sinomeniis, 18 parts of Caulis Piperis Kadsuraes, 23 parts of Cortex erythrinaes, 15 parts in Herba Ephedrae and Radix Glycyrrhizae.With the raw material of the above-mentioned weight proportion cloth bag of packing into, place iron pan or aluminum pot, boil 30-40 minute after, pull cloth bag out, squeeze water purification, be placed on while hot the knee joint site of disease, keeping the cloth bag temperature is 40-45 ℃, external application 20-30 minute, a twice-daily, midfeather 5-6 hour.
The effect example
1. diagnostic criteria
1.1 have a dull ache joint stuffiness from the beginning of common knee joint.Light activity is slightly alleviated, and climate change increases the weight of, and does not repeatedly touchingly heal;
1.2 insidious onset, morbidity slowly is more common in person in middle and old age;
1.3 but local joint mild swelling, activity has noise made in coughing or vomiting thorn sound or grating often.The visible amyotrophy of severe patient, joint deformity;
1.4 the X sheet checks: show osteoporosis, articular surface is irregular, and the joint space is narrow, the sclerosis of subchondral bone matter, and edge lip sample changes hyperosteogeny formation.
Efficacy assessment standard
2.1 recovery from illness: knee joint swelling, pain disappear substantially, it is normal that joint movement function recovers; 2.2 produce effects: the knee joint swelling pain obviously alleviates, the joint movement function normal; 2.3 effectively: the knee joint swelling pain alleviates, and joint movement function partly recovers; 2.4 invalid: as not improve before clinical symptoms and function of joint are treated.
Experimental result
Be diagnosed as 100 patients of knee joint osseous arthritis, carry out continued treatment according to the technical scheme that embodiment 3 provides, schedule to last half a year, 92 of cured persons, 6 of produce effects persons, 2 of nonresponders, total effective rate is 98%.
Model case
4.1 pay certain, the woman, 60 years old, on August 12nd, 2008 was medical.
The continuous pain of patient's both legs knee joint, tired postemphasis.Joint deformity enlargement, the walking for a long time equal pain of standing for a long time, upward downstairs pain increases the weight of.The difficulty of squatting down, knee joint is stretched dysfunction in the wrong, impact life and work.Clapping the X-ray film report shows: occur bony spur between condyle, the joint space narrows down.Be diagnosed as: knee joint osseous arthritis.It is successively treated to Beijing San Jia hospital, and therapeutic effect is not obvious, takes afterwards the technical scheme among the embodiment 1 to treat, after continuously around the treatment, twoly move forward on one's knees away, upper downstairs all without pain, squat down activity freely, recover daily life and work, make a definite diagnosis state of an illness recovery from illness through hospital.
4.2 Yan, the woman, 59 years old, in August, 2012 was medical.
Patient's limping of walking, left knee joint pain is heavier, and deformity can not be stretched the joint of going down on one's knees, the difficulty of squatting down, sometimes suddenly twinge, lower limb is soft to be wanted to fall, and hospital is diagnosed as two knee osteoarthritiss.Ill more than 1 year, once at Beijing hospitalize, unsatisfactory curative effect.Taked afterwards among the embodiment 2 scheme to treat, treatment is made a definite diagnosis through hospital after two months continuously, and this patient cures fully, recovers to work.
4.3 the Wang, the man, 58 years old, in May, 2011 was medical.
The swelling of the right knee joint unknown cause of patient, pain, joint stuffiness, pain during crouching can not be squatted down, fatigue, pain increases the weight of when upward going downstairs.Impact sleep at night.The impact work.Floating patella test is positive, through nuclear magnetic resonance check of knee joint, is diagnosed as: right knee osteoarthritis, arthroedema.Taked afterwards among the embodiment 3 scheme to treat, treated continuously for 3 weeks after, the disappearance of swelling and ache of right knee joint, upper walking downstairs freely.Can participate in field labour, make a definite diagnosis through hospital, this patient cures fully.
Claims (2)
1. Traditional Chinese Medicine for external application compositions for the treatment of knee joint osseous arthritis, it is characterized in that, be to be made by the raw material of following weight portion: Ramulus Cinnamomi 10-25 part, Radix Saposhnikoviae 5-20 part, Sanguis Draxonis 15-30 part, Caulis Sinomenii 15-30 part, Caulis Piperis Kadsurae 15-30 part, Cortex erythrinae 15-30 part, Herba Ephedrae 5-20 part and Radix Glycyrrhizae 5-10 part.
2. a kind of Traditional Chinese Medicine for external application compositions for the treatment of knee joint osseous arthritis as claimed in claim 1, it is characterized in that, be to be made by the raw material of following weight portion: 7 parts in 18 parts of Ramulus Cinnamomi, 15 parts of Radix Saposhnikoviaes, 25 parts of Sanguis Draxonis, 20 parts of Caulis Sinomeniis, 18 parts of Caulis Piperis Kadsuraes, 23 parts of Cortex erythrinaes, 15 parts in Herba Ephedrae and Radix Glycyrrhizae.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210498016.0A CN102920876B (en) | 2012-11-29 | 2012-11-29 | External-application Chinese medicinal composition for treating knee osteoarthritis |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210498016.0A CN102920876B (en) | 2012-11-29 | 2012-11-29 | External-application Chinese medicinal composition for treating knee osteoarthritis |
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| Publication Number | Publication Date |
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| CN102920876A true CN102920876A (en) | 2013-02-13 |
| CN102920876B CN102920876B (en) | 2015-03-25 |
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| CN201210498016.0A Active CN102920876B (en) | 2012-11-29 | 2012-11-29 | External-application Chinese medicinal composition for treating knee osteoarthritis |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104324096A (en) * | 2014-09-24 | 2015-02-04 | 长春中医药大学 | External-use traditional Chinese medicine composition for treating knee osteoarthritis (wind-cold-dampness arthralgia syndrome) |
| CN104784452A (en) * | 2015-04-24 | 2015-07-22 | 王敬侠 | Externally-used traditional Chinese medicine composition for treating arthritis |
| CN105560662A (en) * | 2015-12-18 | 2016-05-11 | 邢健昆 | External-use traditional Chinese medicine composition for treating knee osteoarthritis |
| CN105770734A (en) * | 2016-03-17 | 2016-07-20 | 邢健昆 | Traditional Chinese medicine composition for treating joint sore symptoms of osteoarthritis through external use |
| CN108853390A (en) * | 2018-08-20 | 2018-11-23 | 广西中医药大学 | The Chinese materia medica preparation and preparation method thereof for treating gonitis |
| CN108853219A (en) * | 2017-05-11 | 2018-11-23 | 郜金元 | The Chinese medicinal ointment and preparation method thereof for treating neck, shoulder, waist and leg osteoproliferation |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1695682A (en) * | 2005-06-08 | 2005-11-16 | 昆明滇虹药业有限公司 | External use preparation for treating rheumatisma and bone injuries |
-
2012
- 2012-11-29 CN CN201210498016.0A patent/CN102920876B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1695682A (en) * | 2005-06-08 | 2005-11-16 | 昆明滇虹药业有限公司 | External use preparation for treating rheumatisma and bone injuries |
Non-Patent Citations (1)
| Title |
|---|
| 张金良等: "中医治疗膝关节骨性关节炎回顾", 《中国中医药现代远程教育》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104324096A (en) * | 2014-09-24 | 2015-02-04 | 长春中医药大学 | External-use traditional Chinese medicine composition for treating knee osteoarthritis (wind-cold-dampness arthralgia syndrome) |
| CN104784452A (en) * | 2015-04-24 | 2015-07-22 | 王敬侠 | Externally-used traditional Chinese medicine composition for treating arthritis |
| CN105560662A (en) * | 2015-12-18 | 2016-05-11 | 邢健昆 | External-use traditional Chinese medicine composition for treating knee osteoarthritis |
| CN105770734A (en) * | 2016-03-17 | 2016-07-20 | 邢健昆 | Traditional Chinese medicine composition for treating joint sore symptoms of osteoarthritis through external use |
| CN108853219A (en) * | 2017-05-11 | 2018-11-23 | 郜金元 | The Chinese medicinal ointment and preparation method thereof for treating neck, shoulder, waist and leg osteoproliferation |
| CN108853390A (en) * | 2018-08-20 | 2018-11-23 | 广西中医药大学 | The Chinese materia medica preparation and preparation method thereof for treating gonitis |
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| Publication number | Publication date |
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| CN102920876B (en) | 2015-03-25 |
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