CN102911976A - Method for preparing medium-purity lysine sulphate through fermentation - Google Patents
Method for preparing medium-purity lysine sulphate through fermentation Download PDFInfo
- Publication number
- CN102911976A CN102911976A CN2012104400818A CN201210440081A CN102911976A CN 102911976 A CN102911976 A CN 102911976A CN 2012104400818 A CN2012104400818 A CN 2012104400818A CN 201210440081 A CN201210440081 A CN 201210440081A CN 102911976 A CN102911976 A CN 102911976A
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- CN
- China
- Prior art keywords
- parts
- product
- acid
- lysine sulfate
- lysine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 238000000034 method Methods 0.000 title claims abstract description 31
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 title claims abstract description 28
- 238000000855 fermentation Methods 0.000 title claims abstract description 20
- 230000004151 fermentation Effects 0.000 title claims abstract description 20
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 title claims description 22
- 229910021653 sulphate ion Inorganic materials 0.000 title 1
- 235000018977 lysine Nutrition 0.000 claims abstract description 27
- VJDRZAPMMKFJEA-JEDNCBNOSA-N (2s)-2,6-diaminohexanoic acid;sulfuric acid Chemical compound OS(O)(=O)=O.NCCCC[C@H](N)C(O)=O VJDRZAPMMKFJEA-JEDNCBNOSA-N 0.000 claims abstract description 18
- 239000000047 product Substances 0.000 claims description 56
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 31
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 25
- 229940024606 amino acid Drugs 0.000 claims description 24
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- XUYPXLNMDZIRQH-LURJTMIESA-N N-acetyl-L-methionine Chemical compound CSCC[C@@H](C(O)=O)NC(C)=O XUYPXLNMDZIRQH-LURJTMIESA-N 0.000 claims description 17
- 238000002360 preparation method Methods 0.000 claims description 15
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 14
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- 239000006228 supernatant Substances 0.000 claims description 14
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- 230000000968 intestinal effect Effects 0.000 claims description 7
- 239000004475 Arginine Substances 0.000 claims description 6
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- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 6
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 6
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- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 6
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- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 6
- 150000001510 aspartic acids Chemical class 0.000 claims description 6
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 6
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- 229960000310 isoleucine Drugs 0.000 claims description 6
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 6
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- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 3
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- BVHLGVCQOALMSV-JEDNCBNOSA-N L-lysine hydrochloride Chemical compound Cl.NCCCC[C@H](N)C(O)=O BVHLGVCQOALMSV-JEDNCBNOSA-N 0.000 description 2
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- Fodder In General (AREA)
Abstract
Description
Claims (10)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
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CN 201210440081 CN102911976B (en) | 2012-11-07 | 2012-11-07 | Method for preparing medium-purity lysine sulphate through fermentation |
CN201310403725.0A CN103484493B (en) | 2012-11-07 | 2012-11-07 | Method of preparing lysine through fermentation salt and products thereof |
CN201310403491.XA CN103805626B (en) | 2012-11-07 | 2012-11-07 | Method of preparing lysine through fermentation salt and products thereof |
Applications Claiming Priority (1)
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CN 201210440081 CN102911976B (en) | 2012-11-07 | 2012-11-07 | Method for preparing medium-purity lysine sulphate through fermentation |
Related Child Applications (2)
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CN201310403491.XA Division CN103805626B (en) | 2012-11-07 | 2012-11-07 | Method of preparing lysine through fermentation salt and products thereof |
CN201310403725.0A Division CN103484493B (en) | 2012-11-07 | 2012-11-07 | Method of preparing lysine through fermentation salt and products thereof |
Publications (2)
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CN102911976A true CN102911976A (en) | 2013-02-06 |
CN102911976B CN102911976B (en) | 2013-10-16 |
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CN201310403725.0A Active CN103484493B (en) | 2012-11-07 | 2012-11-07 | Method of preparing lysine through fermentation salt and products thereof |
CN 201210440081 Active CN102911976B (en) | 2012-11-07 | 2012-11-07 | Method for preparing medium-purity lysine sulphate through fermentation |
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CN201310403725.0A Active CN103484493B (en) | 2012-11-07 | 2012-11-07 | Method of preparing lysine through fermentation salt and products thereof |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4393135A (en) * | 1979-12-10 | 1983-07-12 | Ajinomoto Company Incorporated | Method for producing L-glutamic acid by fermentation |
CN1142856A (en) * | 1993-12-08 | 1997-02-12 | 味之素株式会社 | Process for producing L-Lysine by fermentation |
CN1181785A (en) * | 1995-02-20 | 1998-05-13 | 味之素株式会社 | Stress-tolerant microorganism and method of the prodn. of fermentation product |
EP1064106B1 (en) * | 1998-03-18 | 2003-07-16 | Technologies Inc. Biosphere | Method for bio-refining organic waste material to produce denatured and sterile nutrient products |
CN1943392A (en) * | 2005-10-08 | 2007-04-11 | 德古萨股份公司 | Feedstuff additive containing l-lysine |
-
2012
- 2012-11-07 CN CN201310403725.0A patent/CN103484493B/en active Active
- 2012-11-07 CN CN 201210440081 patent/CN102911976B/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4393135A (en) * | 1979-12-10 | 1983-07-12 | Ajinomoto Company Incorporated | Method for producing L-glutamic acid by fermentation |
CN1142856A (en) * | 1993-12-08 | 1997-02-12 | 味之素株式会社 | Process for producing L-Lysine by fermentation |
CN1181785A (en) * | 1995-02-20 | 1998-05-13 | 味之素株式会社 | Stress-tolerant microorganism and method of the prodn. of fermentation product |
EP1064106B1 (en) * | 1998-03-18 | 2003-07-16 | Technologies Inc. Biosphere | Method for bio-refining organic waste material to produce denatured and sterile nutrient products |
CN1943392A (en) * | 2005-10-08 | 2007-04-11 | 德古萨股份公司 | Feedstuff additive containing l-lysine |
Non-Patent Citations (3)
Title |
---|
MANFRED KIRCHER ET AL: "The fermentative production of l-lysine as an animal feed additive", 《CHEMOSPHERE》, 31 December 2001 (2001-12-31), pages 27 - 31 * |
石现瑞 等: "65%赖氨酸硫酸盐物理性状的研究", 《新研究》, no. 7, 31 December 2006 (2006-12-31), pages 18 - 20 * |
邝声耀 等: "新型赖氨酸应用推广的研究进展", 《四川畜牧兽医》, no. 11, 31 December 2005 (2005-12-31) * |
Also Published As
Publication number | Publication date |
---|---|
CN103484493A (en) | 2014-01-01 |
CN103484493B (en) | 2016-02-17 |
CN102911976B (en) | 2013-10-16 |
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Denomination of invention: Method for preparing medium purity lysine sulfate by fermentation Effective date of registration: 20220323 Granted publication date: 20131016 Pledgee: Yongning County Branch of China Agricultural Development Bank Pledgor: NINGXIA EPPEN BIOTECH Co.,Ltd. Registration number: Y2022640000002 |
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Denomination of invention: Method for Preparation of Medium Purity Lysine Sulfate through Fermentation Granted publication date: 20131016 Pledgee: Yongning County Branch of China Agricultural Development Bank Pledgor: NINGXIA EPPEN BIOTECH Co.,Ltd.|INNER MONGOLIA EPPEN BIOTECH Co.,Ltd.|Heilongjiang Yipin Biotechnology Co.,Ltd. Registration number: Y2024640000005 |