CN102908391B - Chinese medicinal composition for treating dermatosis and preparation method and application thereof - Google Patents
Chinese medicinal composition for treating dermatosis and preparation method and application thereof Download PDFInfo
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- CN102908391B CN102908391B CN201210437900.3A CN201210437900A CN102908391B CN 102908391 B CN102908391 B CN 102908391B CN 201210437900 A CN201210437900 A CN 201210437900A CN 102908391 B CN102908391 B CN 102908391B
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Abstract
The invention discloses a Chinese medicinal composition for treating dermatosis. The Chinese medicinal composition comprises the following raw materials in parts by weight: 30-60 parts of vernonia anthelmintica, 30-60 parts of malaytea scurfpea fruit, 15-30 parts of Chinese angelica, 10-20 parts of Chinese magnoliavine fruit (alcohol-treated) and 10-20 parts of plumbago zeylanica. The invention further provides a preparation method and an application of the Chinese medicinal composition. The medicament is easy to prepare, is prepared from vernonia anthelmintica and malaytea scurfpea fruit serving as major raw materials and other medicinal components, and has the effects of activating blood, cooling blood, expelling wind, clearing away cold, dissipating blood stasis, killing parasites and curing ringworms; and pathogenesis of vitligo and psoriasis are eliminated fundamentally, focuses of infection are eliminated directly, and the aim of curing is fulfilled.
Description
Technical field
The present invention relates to one and treat dermopathic medicine, be specifically related to one and treat vitiligo and psoriatic Chinese medicine composition, belong to medical art.
Background technology
Vitiligo (vitiligo) is a kind of posteriority melanin depigmentation dermatoses, show as clinically differ in size, depigmentation speckle that form differs, number is indefinite, clear-cut margin, and some white maculas peripheral normal skin place pigment increases.Leukodermic white macula can betide any position of whole body, but it is common with the fold place such as exposure portion and external genitalia skins such as face, cervical region, the back of the hand, because white macula is exposed to the appearance that visual position can affect patient, and then also can have influence on the orthobiosis of patient, cause very large mental pressure, therefore the person that do not seek medical advice is a lot, and all very urgent.
Psoriasis is commonly called as psoriasis, and sickness rate is high, and the course of disease is longer, and pathogenesis relates to the factors such as heredoimmunity, inflammatory mediator, neurotransmitter, Cell apoptosis and proliferation, microcirculation disturbance.Psoriatic's throughout world various places, all can fall ill at different nationalities, sex, age.According to domestic literature, China's psoriatic's sickness rate accounts for 0.5% ~ 2% of total population, the psoriatic of nearly 10% ~ 30% has family history, this disease has a strong impact on the social life of patient due to reasons such as it are chronic, touching repeatedly, obstinate difficulty heals, relapse rate is high, causes great health and psychological misery.Meanwhile, due to this sick recurrent exerbation, often repeatedly need treat, also bring heavy financial burden to patient.
Have a lot for the treatment of vitiligo and psoriatic medicine now, existing Chinese medicine also has Western medicine, although can play a role, can not effect a radical cure, easily recur, drug dependence is strong.How treating a great problem that vitiligo and psoriasis have been world medicine field, is one of disease of domestic and international dermal region primary study control.
Summary of the invention
In order to overcome the deficiencies in the prior art, the invention provides one and treating dermopathic Chinese medicine composition, this Chinese medicine composition has to vitiligo and psoriasis the advantage that stability is high, therapeutic effect is good.
The invention also discloses the preparation method and application of said composition, its preparation is simple, evident in efficacy, is convenient to the large application of industrialization.
The present invention is achieved by the following technical solutions:
One treats dermopathic Chinese medicine composition, comprises the raw material of following weight portion: Caulis Vernoniae andersonii 30 ~ 60 parts, Fructus Psoraleae 30 ~ 60 parts, Radix Angelicae Sinensis 15 ~ 30 parts, Fructus Schisandrae Chinensis (processed with wine) 10 ~ 20 parts, Radix Plumbaginis Zeylanicae 10 ~ 20 parts.
In above-mentioned Chinese medicine composition, preferably include the raw material of following weight portion: Caulis Vernoniae andersonii 36 parts, Fructus Psoraleae 36 parts, Radix Angelicae Sinensis 18 parts, Fructus Schisandrae Chinensis (processed with wine) 18 parts, Radix Plumbaginis Zeylanicae 12 parts.
Main formula raw material of the present invention is Caulis Vernoniae andersonii, Fructus Psoraleae, Radix Angelicae Sinensis, Fructus Schisandrae Chinensis, Radix Plumbaginis Zeylanicae, and each crude drug effect is as follows:
Caulis Vernoniae andersonii, the mature fruit of feverfew Caulis Vernoniae andersonii Vernonia anthelmintica Willd.Autumn, picking fruit, dried.Mainly originate in the Keshen in Xinjiang, Aksu Prefecture, Uygur's name Aunar lira, have heat clearing and inflammation relieving, blood circulation promoting and blood stasis dispelling, the function of parasite killing, is used for the treatment of dermatosis.
Fructus Psoraleae, the dry mature fruit of legumes psoraleae Psoralea corylifolia L., has warming the kidney to activate YANG, helping inspiration to relieve asthma, the function of wet spleen antidiarrheal, for insufficiency of kidney-YANG, impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffer from a deficiency of the kidney and breathe heavily, Diarrhoea, external curing vitiligo, alopecia areata.
Radix Angelicae Sinensis, the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels, having enriches blood invigorates blood circulation, the function of menstruction regulating and pain relieving, loosening bowel to relieve constipation, for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, dryness of the intestine constipation.
Fructus Schisandrae Chinensis, the dry mature fruit of magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill., practises and claims " Radix Schisandrae Bicoloris ", has the function of astringent or styptic treatment for spontaneous sweating, the supplementing QI for promoting the production of body fluid of convergence, kidney calming, for chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous sweating, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, palpitation and insomnia.
Radix Plumbaginis Zeylanicae, the dry stem branch of Plumbaginaceae plant Radix Plumbaginis Zeylanicae Plumbago zeylanis L. not with leaf, the whole year can adopt, and has the function of the dissipating blood stasis that dispels the wind, removing toxic substances parasite killing, for controlling toxic swelling malignant boil, scabies.
The present invention, based on Caulis Vernoniae andersonii, Fructus Psoraleae, is aided with other drug composition, and promoting blood circulation and cooling blood, expelling wind and cold, dissipating blood stasis blood stasis dispelling, parasite killing treat tinea, fundamentally solve vitiligo and psoriatic pathogenic factor, directly except focus, reach the object of radical cure.
On the basis of original formula, some other potentiation raw material can also be added and strengthen curative effect, such as can add the Radix Astragali further, Rhizoma Chuanxiong, play dissipating blood stasis poison holding, the effect of invigorating QI to consolidate the body surface resistance, the new side formed is (weight portion): Caulis Vernoniae andersonii 30 ~ 60 parts, Fructus Psoraleae 30 ~ 60 parts, Radix Angelicae Sinensis 15 ~ 30 parts, Fructus Schisandrae Chinensis (processed with wine) 10 ~ 20 parts, Radix Plumbaginis Zeylanicae 10 ~ 20 parts, the Radix Astragali 10 ~ 40 parts, Rhizoma Chuanxiong 9 ~ 18 parts, preferred weight part is: Caulis Vernoniae andersonii 36 parts, Fructus Psoraleae 36 parts, Radix Angelicae Sinensis 18 parts, Fructus Schisandrae Chinensis (processed with wine) 18 parts, Radix Plumbaginis Zeylanicae 12 parts, the Radix Astragali 25 parts, Rhizoma Chuanxiong 12 parts.
On the basis of original formula, Rhizoma Bistortae can also be added, Radix Saposhnikoviae, Rhizoma Chuanxiong, Rhizoma Dioscoreae Hypoglaucae forms new sub-side, Rhizoma Bistortae heat-clearing and toxic substances removing, detumescence hemostasis, Radix Saposhnikoviae inducing diaphoresis to dispel wind, pain relieving relieving convulsion, Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping, Rhizoma Dioscoreae Hypoglaucae dampness removing goes turbid, wind expelling stagnation removing, new sub-side is (weight portion): Caulis Vernoniae andersonii 30 ~ 60 parts, Fructus Psoraleae 30 ~ 60 parts, Radix Angelicae Sinensis 15 ~ 30 parts, Fructus Schisandrae Chinensis (processed with wine) 10 ~ 20 parts, Radix Plumbaginis Zeylanicae 10 ~ 20 parts, Rhizoma Bistortae 8 ~ 20 parts, Radix Saposhnikoviae 9 ~ 18 parts, Rhizoma Chuanxiong 9 ~ 18 parts, Rhizoma Dioscoreae Hypoglaucae 16 ~ 32 parts, preferred weight part is: Caulis Vernoniae andersonii 36 parts, Fructus Psoraleae 36 parts, Radix Angelicae Sinensis 18 parts, Fructus Schisandrae Chinensis (processed with wine) 18 parts, Radix Plumbaginis Zeylanicae 12 parts, Rhizoma Bistortae 10 parts, Radix Saposhnikoviae 10 parts, Rhizoma Chuanxiong 12 parts, Rhizoma Dioscoreae Hypoglaucae 20 parts.
On the basis of original formula, Rhizoma Alpiniae Officinarum can also be added, the Radix Angelicae Dahuricae, the Fructus Kochiae forms new sub-side, Rhizoma Alpiniae Officinarum stomach warming preventing or arresting vomiting, dispersing cold for relieving pain, the Radix Angelicae Dahuricae induces sweat cold expelling, wind-expelling pain-stopping, detumescence and apocenosis, Fructus Kochiae clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching, new sub-side is (weight portion): Caulis Vernoniae andersonii 30 ~ 60 parts, Fructus Psoraleae 30 ~ 60 parts, Radix Angelicae Sinensis 15 ~ 30 parts, Fructus Schisandrae Chinensis (processed with wine) 10 ~ 20 parts, Radix Plumbaginis Zeylanicae 10 ~ 20 parts, Rhizoma Alpiniae Officinarum 5 ~ 30 parts, the Radix Angelicae Dahuricae 20 ~ 30 parts, the Fructus Kochiae 10 ~ 20 parts, preferred weight part is: Caulis Vernoniae andersonii 36 parts, Fructus Psoraleae 36 parts, Radix Angelicae Sinensis 18 parts, Fructus Schisandrae Chinensis (processed with wine) 18 parts, Radix Plumbaginis Zeylanicae 12 parts, Rhizoma Alpiniae Officinarum 18 parts, the Radix Angelicae Dahuricae 25 parts, the Fructus Kochiae 15 parts.
On the basis of original formula, Concha Ostreae can also be added, Concha Ostreae has effect of YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving, all right trace element supplement, new sub-side is (weight portion): Caulis Vernoniae andersonii 30 ~ 60 parts, Fructus Psoraleae 30 ~ 60 parts, Radix Angelicae Sinensis 15 ~ 30 parts, Fructus Schisandrae Chinensis (processed with wine) 10 ~ 20 parts, Radix Plumbaginis Zeylanicae 10 ~ 20 parts, Concha Ostreae 5 ~ 30 parts, and preferred weight part is: Caulis Vernoniae andersonii 36 parts, Fructus Psoraleae 36 parts, Radix Angelicae Sinensis 18 parts, Fructus Schisandrae Chinensis (processed with wine) 18 parts, Radix Plumbaginis Zeylanicae 12 parts, Concha Ostreae 10 parts.
On the basis of original formula, Rhizoma Smilacis Glabrae can also be added, Cortex Dictamni, Herba Taraxaci, Herba Portulacae, Rhizoma Smilacis Glabrae is the dry rhizome of liliaceous plant smilacis glabra Smilax glabra Roxb., another name Limonitum, thorn Polyporus, Cortex Ampelopsis Aconitifoliae Radicis, there is effect of removing toxic substances dehumidifying, Cortex Dictamni has heat clearing and damp drying, dispel the wind removing toxic substances effect, Herba Taraxaci has heat-clearing and toxic substances removing, effect of dispersing swelling and dissipating binds, Herba Portulacae has heat-clearing and toxic substances removing, effect of cooling blood for hemostasis, new sub-side is (weight portion): Caulis Vernoniae andersonii 30 ~ 60 parts, Fructus Psoraleae 30 ~ 60 parts, Radix Angelicae Sinensis 15 ~ 30 parts, Fructus Schisandrae Chinensis (processed with wine) 10 ~ 20 parts, Radix Plumbaginis Zeylanicae 10 ~ 20 parts, Rhizoma Smilacis Glabrae 30 ~ 40 parts, Cortex Dictamni 10 ~ 25 parts, Herba Taraxaci 20 ~ 25 parts, Herba Portulacae 10 ~ 20 parts, preferred weight part is: Caulis Vernoniae andersonii 36 parts, Fructus Psoraleae 36 parts, Radix Angelicae Sinensis 18 parts, Fructus Schisandrae Chinensis (processed with wine) 18 parts, Radix Plumbaginis Zeylanicae 12 parts, Rhizoma Smilacis Glabrae 35 parts, Cortex Dictamni 15 parts, Herba Taraxaci 22 parts, Herba Portulacae 15 parts.
On the basis of original formula, Lignum Dalbergiae Odoriferae can also be added, Radix Notoginseng, Semen Persicae, Flos Carthami, Lignum Dalbergiae Odoriferae promoting flow of QI and blood, regulating QI to relieve pain, Radix Notoginseng dissipating blood stasis stops blooding, subduing swelling and relieving pain, Semen Persicae blood circulation promoting and blood stasis dispelling, Flos Carthami promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, new sub-side is (weight portion): Caulis Vernoniae andersonii 30 ~ 60 parts, Fructus Psoraleae 30 ~ 60 parts, Radix Angelicae Sinensis 15 ~ 30 parts, Fructus Schisandrae Chinensis (processed with wine) 10 ~ 20 parts, Radix Plumbaginis Zeylanicae 10 ~ 20 parts, Lignum Dalbergiae Odoriferae 5 ~ 10 parts, Radix Notoginseng 10 ~ 25 parts, 15 ~ 20 parts, Semen Persicae (stir-fry), 5 ~ 10 parts, Flos Carthami, preferred weight part is: Caulis Vernoniae andersonii 36 parts, Fructus Psoraleae 36 parts, Radix Angelicae Sinensis 18 parts, Fructus Schisandrae Chinensis (processed with wine) 18 parts, Radix Plumbaginis Zeylanicae 12 parts, Lignum Dalbergiae Odoriferae 6 parts, Radix Notoginseng 12 parts, 20 parts, Semen Persicae (stir-fry), 8 parts, Flos Carthami.
On the basis of original formula, Radix Rehmanniae can also be added, Radix Cynanchi Atrati, Cortex Moutan, Radix Rehmanniae clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, Radix Cynanchi Atrati clearing away heat and cooling blood, detoxification sore treatment, Cortex Moutan clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, new sub-side is (weight portion): Caulis Vernoniae andersonii 30 ~ 60 parts, Fructus Psoraleae 30 ~ 60 parts, Radix Angelicae Sinensis 15 ~ 30 parts, Fructus Schisandrae Chinensis (processed with wine) 10 ~ 20 parts, Radix Plumbaginis Zeylanicae 10 ~ 20 parts, Radix Rehmanniae 25 ~ 30 parts, Radix Cynanchi Atrati 5 ~ 10 parts, Cortex Moutan 15 ~ 30 parts, preferred weight part is: Caulis Vernoniae andersonii 36 parts, Fructus Psoraleae 36 parts, Radix Angelicae Sinensis 18 parts, Fructus Schisandrae Chinensis (processed with wine) 18 parts, Radix Plumbaginis Zeylanicae 12 parts, Radix Rehmanniae 28 parts, Radix Cynanchi Atrati 8 parts, Cortex Moutan 20 parts.
On the basis of original formula, Semen Cuscutae can also be added, Fructus Ligustri Lucidi, Radix Polygoni Multiflori, Semen Cuscutae, Fructus Ligustri Lucidi liver and kidney tonifying, Radix Polygoni Multiflori removing toxicity for eliminating carbuncles, new sub-side is (weight portion): Caulis Vernoniae andersonii 30 ~ 60 parts, Fructus Psoraleae 30 ~ 60 parts, Radix Angelicae Sinensis 15 ~ 30 parts, Fructus Schisandrae Chinensis (processed with wine) 10 ~ 20 parts, Radix Plumbaginis Zeylanicae 10 ~ 20 parts, Semen Cuscutae 20 ~ 30 parts, Fructus Ligustri Lucidi 10 ~ 15 parts, Radix Polygoni Multiflori 15 ~ 25 parts, preferred weight part is: Caulis Vernoniae andersonii 36 parts, Fructus Psoraleae 36 parts, Radix Angelicae Sinensis 18 parts, Fructus Schisandrae Chinensis (processed with wine) 18 parts, Radix Plumbaginis Zeylanicae 12 parts, Semen Cuscutae 25 parts, Fructus Ligustri Lucidi 12 parts, Radix Polygoni Multiflori 20 parts.
On the basis of original formula, box fruit rattan can also be added, Fructus Mume, Fructus Tribuli, box fruit rattan (convolvulaceous plant box fruit rattan Operculina turpethum (L.) S.Manso dry rhizome) inducing diuresis to remove edema, relaxing muscles and tendons and activating QI and blood in the collateral, Fructus Mume is astringed the lung, astringing intestine to stop diarrhea, promote the production of body fluid, Fructus Tribuli suppressing the hyperactive liver resolving depression, promoting blood circulation by removing wind, improving eyesight is antipruritic, new sub-side is (weight portion): Caulis Vernoniae andersonii 30 ~ 60 parts, Fructus Psoraleae 30 ~ 60 parts, Radix Angelicae Sinensis 15 ~ 30 parts, Fructus Schisandrae Chinensis (processed with wine) 10 ~ 20 parts, Radix Plumbaginis Zeylanicae 10 ~ 20 parts, box fruit 12 ~ 20 parts, rattan, Fructus Mume 10 ~ 20 parts, Fructus Tribuli (stir-fry) 15 ~ 20 parts, preferred weight part is: Caulis Vernoniae andersonii 36 parts, Fructus Psoraleae 36 parts, Radix Angelicae Sinensis 18 parts, Fructus Schisandrae Chinensis (processed with wine) 18 parts, Radix Plumbaginis Zeylanicae 12 parts, box fruit 18 parts, rattan, Fructus Mume 15 parts, Fructus Tribuli (stir-fry) 18 parts.
as from the foregoing,the basis of original formula adds different synergistic components and can be derived multiple son side, each sub-Fang Junneng plays treatment vitiligo and psoriatic effect, and therapeutic effect is increasing in varying degrees.The each group of synergistic component added in above-mentioned each son side can also use mutually in mixing superposition, form new sub-side, such as, the basis of original formula can add Lignum Dalbergiae Odoriferae, Radix Notoginseng, Semen Persicae (stir-fry), Flos Carthami, Radix Rehmanniae, Radix Cynanchi Atrati, Cortex Moutan composition simultaneously, form new sub-side, other synergistic components also can be used with.
Chinese medicine composition of the present invention can be made into capsule, also can add corresponding adjuvant and make tablet, pill, granule etc.Prepare different dosage form adjuvant only used different, effective ingredient or the same, therapeutic effect is also identical or approximate.The adjuvant of tablet is starch, microcrystalline Cellulose, pregelatinized Starch, lactose, carboxymethylstach sodium, Extra Sodium Carboxylmethyl Starch, low-substituted hydroxypropyl cellulose, hypromellose, Pulvis Talci, magnesium stearate; The adjuvant of pill is starch, microcrystalline Cellulose, carboxymethylstach sodium, hypromellose; The adjuvant of granule is multitudinous Icing Sugar, dextrin; The adjuvant of capsule is starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethylstach sodium, Extra Sodium Carboxylmethyl Starch, hypromellose, Pulvis Talci, silicon dioxide, magnesium stearate.
The preparation method of Chinese medicine composition, is characterized in that comprising the following steps:
(1) Caulis Vernoniae andersonii is ground into fine powder, for subsequent use;
(2) remaining crude drug is mixed, with the ethanol extraction 2 ~ 3 times of 6 ~ 12 quality, 65 ~ 80vol% doubly, merge extractive liquid;
(3) extracting solution is condensed into clear paste or the thick paste that 60-80 DEG C of relative density is 1.20 ~ 1.40;
(4) clear paste, Caulis Vernoniae andersonii fine powder are mixed with the adjuvant of survival dose, make the Chinese medicine composition of required dosage form.
In above-mentioned steps (2), when extracting for 2 times, each 2h; When extracting for 3 times, 2 hours first times, second time 1 hour, second time 1 hour.
The present invention prepares simply, based on Caulis Vernoniae andersonii, Fructus Psoraleae, is aided with other drug composition, there is effect of promoting blood circulation and cooling blood, expelling wind and cold, dissipating blood stasis blood stasis dispelling, parasite killing treatment tinea, fundamentally solve vitiligo and onset of psoriasis reason, directly except focus, reach the object of radical cure.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described, it is to be understood that following explanation is only to explain the present invention, do not limit its content.If following crude drug consumption, without specified otherwise, is weight portion.
embodiment 1
Get Caulis Vernoniae andersonii 36 parts, Fructus Psoraleae 36 parts, Radix Angelicae Sinensis 18 parts, Fructus Schisandrae Chinensis (processed with wine) 18 parts, Radix Plumbaginis Zeylanicae 12 parts, make capsule according to following method:
(1) Caulis Vernoniae andersonii is ground into fine powder, for subsequent use;
(2) all the other medical materials ethanol extraction 3 times of 8 times amount 75vol%, 2 hours first times, second time 1 hour, second time 1 hour, merge extractive liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.20 ~ 1.30 (70 DEG C);
(3) Caulis Vernoniae andersonii fine powder and above-mentioned thick paste are mixed, dry, get dry extract;
(4) dried cream powder is broken into fine powder, adds appropriate pharmaceutic adjuvant, mixing, granulate, dry, add the magnesium stearate of 1%, mixing, encapsulated, to obtain final product, every dress 0.5g.
embodiment 2
Get Caulis Vernoniae andersonii 30 parts, Fructus Psoraleae 60 parts, Radix Angelicae Sinensis 15 parts, Fructus Schisandrae Chinensis (processed with wine) 20 parts, Radix Plumbaginis Zeylanicae 10 parts, make capsule according to following method:
(1) Caulis Vernoniae andersonii is ground into fine powder, for subsequent use;
(2) all the other medical materials 6 times amount 80vol% ethanol extraction 2 times, each 2 hours, merge extractive liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25 ~ 1.35 (60 DEG C);
(3) fine medicinal material powder and above-mentioned thick paste are mixed, dry, get dry extract;
(4) dried cream powder is broken into fine powder, adds appropriate pharmaceutic adjuvant, mixing, granulate, dry, add the magnesium stearate of 0.5%, mixing, encapsulated, to obtain final product, every dress 0.5g.
embodiment 3
Get Caulis Vernoniae andersonii 60 parts, Fructus Psoraleae 30 parts, Radix Angelicae Sinensis 30 parts, Fructus Schisandrae Chinensis (processed with wine) 10 parts, Radix Plumbaginis Zeylanicae 20 parts, make capsule according to following method:
(1) Caulis Vernoniae andersonii is ground into fine powder, for subsequent use;
(2) all the other medical materials 12 times amount 65vol% ethanol extraction 2 times, each 2 hours, merge extractive liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.30 ~ 1.35 (80 DEG C);
(3) fine medicinal material powder and above-mentioned thick paste are mixed, dry, get dry extract;
(4) dried cream powder is broken into fine powder, adds appropriate pharmaceutic adjuvant, mixing, granulate, dry, add the magnesium stearate of 0.8%, mixing, encapsulated, to obtain final product, every dress 0.5g.
embodiment 4
Get Caulis Vernoniae andersonii 36 parts, Fructus Psoraleae 36 parts, Radix Angelicae Sinensis 18 parts, Fructus Schisandrae Chinensis (processed with wine) 18 parts, Radix Plumbaginis Zeylanicae 12 parts, the Radix Astragali 25 parts, Rhizoma Chuanxiong 12 parts, make capsule according to following method:
(1) Caulis Vernoniae andersonii is ground into fine powder, for subsequent use;
(2) all the other medical materials 10 times amount 70vol% ethanol extraction 2 times, each 2 hours, merge extractive liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25 ~ 1.35 (75 DEG C);
(3) fine medicinal material powder and above-mentioned thick paste are mixed, dry, get dry extract;
(4) dried cream powder is broken into fine powder, adds appropriate pharmaceutic adjuvant, mixing, granulate, dry, add the magnesium stearate of 1.5%, mixing, encapsulated, to obtain final product, every dress 0.5g.
embodiment 5
Get Caulis Vernoniae andersonii 36 parts, Fructus Psoraleae 36 parts, Radix Angelicae Sinensis 18 parts, Fructus Schisandrae Chinensis (processed with wine) 18 parts, Radix Plumbaginis Zeylanicae 12 parts, Rhizoma Bistortae 10 parts, Radix Saposhnikoviae 10 parts, Rhizoma Chuanxiong 12 parts, Rhizoma Dioscoreae Hypoglaucae 20 parts, make capsule according to following method:
(1) Caulis Vernoniae andersonii is ground into fine powder, for subsequent use;
(2) all the other medical materials 8 times amount 80vol% ethanol extraction 2 times, each 2 hours, merge extractive liquid, filter, filtrate is concentrated into the clear paste that relative density is 1.20 ~ 1.25 (80 DEG C);
(3) one-step palletizing in fluidized drying pelletizer by fine medicinal material powder and above-mentioned clear paste, dry, add the magnesium stearate of 0.8%, mixing, encapsulated, to obtain final product, every dress 0.5g.
embodiment 6
Get Caulis Vernoniae andersonii 36 parts, Fructus Psoraleae 36 parts, Radix Angelicae Sinensis 18 parts, Fructus Schisandrae Chinensis (processed with wine) 18 parts, Radix Plumbaginis Zeylanicae 12 parts, Rhizoma Alpiniae Officinarum 18 parts, the Radix Angelicae Dahuricae 25 parts, the Fructus Kochiae 15 parts, make capsule according to the method for embodiment 1.
embodiment 7
Get Caulis Vernoniae andersonii 36 parts, Fructus Psoraleae 36 parts, Radix Angelicae Sinensis 18 parts, Fructus Schisandrae Chinensis (processed with wine) 18 parts, Radix Plumbaginis Zeylanicae 12 parts, Concha Ostreae 10 parts, make capsule according to the method for embodiment 2.
embodiment 8
Get Caulis Vernoniae andersonii 36 parts, Fructus Psoraleae 36 parts, Radix Angelicae Sinensis 18 parts, Fructus Schisandrae Chinensis (processed with wine) 18 parts, Radix Plumbaginis Zeylanicae 12 parts, Rhizoma Smilacis Glabrae 35 parts, Cortex Dictamni 15 parts, Herba Taraxaci 22 parts, Herba Portulacae 15 parts, make capsule according to the method for embodiment 3.
embodiment 9
Get Caulis Vernoniae andersonii 36 parts, Fructus Psoraleae 36 parts, Radix Angelicae Sinensis 18 parts, Fructus Schisandrae Chinensis (processed with wine) 18 parts, Radix Plumbaginis Zeylanicae 12 parts, Lignum Dalbergiae Odoriferae 6 parts, Radix Notoginseng 12 parts, 20 parts, Semen Persicae (stir-fry), 8 parts, Flos Carthami, make capsule according to the method for embodiment 4.
embodiment 10
Get Caulis Vernoniae andersonii 36 parts, Fructus Psoraleae 36 parts, Radix Angelicae Sinensis 18 parts, Fructus Schisandrae Chinensis (processed with wine) 18 parts, Radix Plumbaginis Zeylanicae 12 parts, Radix Rehmanniae 28 parts, Radix Cynanchi Atrati 8 parts, Cortex Moutan 20 parts, make capsule according to the method for embodiment 5.
embodiment 11
Get Caulis Vernoniae andersonii 36 parts, Fructus Psoraleae 36 parts, Radix Angelicae Sinensis 18 parts, Fructus Schisandrae Chinensis (processed with wine) 18 parts, Radix Plumbaginis Zeylanicae 12 parts, Semen Cuscutae 25 parts, Fructus Ligustri Lucidi 12 parts, Radix Polygoni Multiflori 20 parts, make capsule according to the method for embodiment 1.
embodiment 12
Get Caulis Vernoniae andersonii 36 parts, Fructus Psoraleae 36 parts, Radix Angelicae Sinensis 18 parts, Fructus Schisandrae Chinensis (processed with wine) 18 parts, Radix Plumbaginis Zeylanicae 12 parts, box fruit 18 parts, rattan, Fructus Mume 15 parts, Fructus Tribuli (stir-fry) 18 parts, make capsule according to the method for embodiment 1.
embodiment 13
Get Caulis Vernoniae andersonii 36 parts, Fructus Psoraleae 36 parts, Radix Angelicae Sinensis 18 parts, Fructus Schisandrae Chinensis (processed with wine) 18 parts, Radix Plumbaginis Zeylanicae 12 parts, Rhizoma Bistortae 10 parts, Radix Saposhnikoviae 10 parts, Rhizoma Chuanxiong 12 parts, Rhizoma Dioscoreae Hypoglaucae 20 parts, Radix Rehmanniae 28 parts, Radix Cynanchi Atrati 8 parts, Cortex Moutan 20 parts, make capsule according to the method for embodiment 3.
embodiment 14
Get Caulis Vernoniae andersonii 36 parts, Fructus Psoraleae 36 parts, Radix Angelicae Sinensis 18 parts, Fructus Schisandrae Chinensis (processed with wine) 18 parts, Radix Plumbaginis Zeylanicae 12 parts, Rhizoma Smilacis Glabrae 35 parts, Cortex Dictamni 15 parts, Herba Taraxaci 22 parts, Herba Portulacae 15 parts, Semen Cuscutae 25 parts, Fructus Ligustri Lucidi 12 parts, Radix Polygoni Multiflori 20 parts, Concha Ostreae 10 parts, make capsule according to the method for embodiment 2.
embodiment 15
Get Caulis Vernoniae andersonii 60 parts, Fructus Psoraleae 30 parts, Radix Angelicae Sinensis 30 parts, Fructus Schisandrae Chinensis (processed with wine) 10 parts, Radix Plumbaginis Zeylanicae 20 parts, Rhizoma Bistortae 8 parts, Radix Saposhnikoviae 18 parts, Rhizoma Chuanxiong 9 parts, Rhizoma Dioscoreae Hypoglaucae 32 parts, make capsule according to the method for embodiment 1.
embodiment 16
Get Caulis Vernoniae andersonii 30 parts, Fructus Psoraleae 60 parts, Radix Angelicae Sinensis 15 parts, Fructus Schisandrae Chinensis (processed with wine) 20 parts, Radix Plumbaginis Zeylanicae 10 parts, Rhizoma Bistortae 20 parts, Radix Saposhnikoviae 9 parts, Rhizoma Chuanxiong 18 parts, Rhizoma Dioscoreae Hypoglaucae 16 parts, make capsule according to the method for embodiment 1.
embodiment 17
Get Caulis Vernoniae andersonii 60 parts, Fructus Psoraleae 30 parts, Radix Angelicae Sinensis 30 parts, Fructus Schisandrae Chinensis (processed with wine) 10 parts, Radix Plumbaginis Zeylanicae 20 parts, the Radix Astragali 40 parts, Rhizoma Chuanxiong 9 parts, make capsule according to the method for embodiment 2.
embodiment 18
Get Caulis Vernoniae andersonii 30 parts, Fructus Psoraleae 60 parts, Radix Angelicae Sinensis 15 parts, Fructus Schisandrae Chinensis (processed with wine) 20 parts, Radix Plumbaginis Zeylanicae 10 parts, Rhizoma Alpiniae Officinarum 5 parts, the Radix Angelicae Dahuricae 30 parts, the Fructus Kochiae 10 parts, make capsule according to the method for embodiment 4.
embodiment 19
Get Caulis Vernoniae andersonii 60 parts, Fructus Psoraleae 30 parts, Radix Angelicae Sinensis 30 parts, Fructus Schisandrae Chinensis (processed with wine) 10 parts, Radix Plumbaginis Zeylanicae 20 parts, Rhizoma Alpiniae Officinarum 30 parts, the Radix Angelicae Dahuricae 20 parts, the Fructus Kochiae 20 parts, make capsule according to following method.
embodiment 20
Get Caulis Vernoniae andersonii 60 parts, Fructus Psoraleae 30 parts, Radix Angelicae Sinensis 30 parts, Fructus Schisandrae Chinensis (processed with wine) 10 parts, Radix Plumbaginis Zeylanicae 20 parts, Concha Ostreae 5 parts, Lignum Dalbergiae Odoriferae 10 parts, Radix Notoginseng 25 parts, 15 parts, Semen Persicae (stir-fry), 5 parts, Flos Carthami, make capsule according to the method for embodiment 5.
embodiment 21
Get Caulis Vernoniae andersonii 36 parts, Fructus Psoraleae 36 parts, Radix Angelicae Sinensis 18 parts, Fructus Schisandrae Chinensis (processed with wine) 18 parts, Radix Plumbaginis Zeylanicae 12 parts, box fruit 12 parts, rattan, Fructus Mume 20 parts, Fructus Tribuli (stir-fry) 15 parts, make capsule according to the method for embodiment 4.
embodiment 22
Get Caulis Vernoniae andersonii 36 parts, Fructus Psoraleae 36 parts, Radix Angelicae Sinensis 18 parts, Fructus Schisandrae Chinensis (processed with wine) 18 parts, Radix Plumbaginis Zeylanicae 12 parts, Semen Cuscutae 30 parts, Fructus Ligustri Lucidi 10 parts, Radix Polygoni Multiflori 25 parts, make capsule according to the method for embodiment 4.
embodiment 23
Get Caulis Vernoniae andersonii 30 parts, Fructus Psoraleae 60 parts, Radix Angelicae Sinensis 15 parts, Fructus Schisandrae Chinensis (processed with wine) 20 parts, Radix Plumbaginis Zeylanicae 10 parts, Radix Rehmanniae 25 parts, Radix Cynanchi Atrati 10 parts, Cortex Moutan 15 parts, box fruit 20 parts, rattan, Fructus Mume 10 parts, Fructus Tribuli (stir-fry) 10 parts, make capsule according to the method for embodiment 3.
embodiment 24
Get Caulis Vernoniae andersonii 30 parts, Fructus Psoraleae 60 parts, Radix Angelicae Sinensis 15 parts, Fructus Schisandrae Chinensis (processed with wine) 20 parts, Radix Plumbaginis Zeylanicae 10 parts, Rhizoma Alpiniae Officinarum 5 parts, the Radix Angelicae Dahuricae 30 parts, the Fructus Kochiae 10 parts, Concha Ostreae 30 parts, Lignum Dalbergiae Odoriferae 5 parts, Radix Notoginseng 10 parts, 20 parts, Semen Persicae (stir-fry), 10 parts, Flos Carthami, make capsule according to the method for embodiment 1.
Except the compositions in above-described embodiment, those skilled in the art can also obtain the formula of other raw materials composition according to foregoing description, above-described embodiment not limits content of the present invention.In addition, except conventionally making except capsule by compositions, disclosed in prior art, conventional method the present composition can also be made tablet, pill, granule.
Compositions of the present invention has no side effect, and can effect a radical cure vitiligo and psoriasis, and treatment cycle is short, rapid-action, carries out clinical experiment below to medicine of the present invention, proves its effect.
one, vitiligo clinical experiment is treated
1, case source
600 routine patients with vitiligo are chosen, wherein man 330 example, female 270 example at each large Dermatology of this city; 15 ~ 53 years old age, average 26.8 years old; The course of disease 2 months ~ 18 years, average course of disease 2.0 years; Progressive stage 190, is routine, stable phase 410 example.Its diagnosis all meets the fixed diagnostic criteria of national combination of Chinese and Western medicine Society of Dermatology and Venereology pigment disease length of schooling.
2, test method
Patient is equally divided into 10 groups, respectively organizes no difference of science of statistics, often organize the medicine that patient uses the embodiment of the present invention respectively, every day 3 times, each 2, surrounding is a course for the treatment of, takes 3 months continuously.
3, criterion of therapeutical effect
Effective: white macula partial remission or reduce, the area recovering normal skin tone accounts for skin lesion area >=50%;
Effective: white macula partial remission or reduce, the area recovering normal skin tone accounts for skin lesion area >=10% and < 50%;
Invalid: the area that white macula recovers normal skin tone accounts for skin lesion area < 10%.
4, therapeutic outcome is respectively organized patient treatment situation and is seen the following form 1.
two, psoriasis clinical experiment is treated
1, case source
Select outpatient service psoriatic 522 example, wherein man 302 example, female 220 example; 20 ~ 65 years old age, average (40.5 ± 10.8) year; Course of disease March ~ 18 year, average (12.4 ± 6.9) year; All patients all meet psoriasis vulgaris diagnostic criteria, and psoriasis area severity score (PASI) is all greater than 1O and divides.
2, test method
Patient is equally divided into 9 groups, Gender, age, the course of disease, the equal no difference of science of statistics of PASI diversity of values (P>0.05) between group, there is comparability, often organize the medicine that patient uses the embodiment of the present invention respectively, every day 3 times, each 2, surrounding is a course for the treatment of, takes 3 months continuously.
3, criterion of therapeutical effect
Using psoriatic skin injury area and psoriasis severity score (PASI) as standard, evaluate the clinical symptoms of patient and sign (squama, infiltration, erythema), PASI decline index is the percent value of marking before difference and the treatment of scoring before and after treatment.With the foundation of PASI scoring decline index as efficacy determination.
effective: PASI marks decline index more than 60%;
effectively: PASI scoring decline index is 30% ~ 59%;
invalid: PASI scoring decline index is less than 30%.
4, therapeutic outcome
Each group of patient treatment situation sees the following form 2.
Above-mentioned vitiligo and the psoriatic overwhelming majority when treating shows good effect, and rapid-action, through further taking this medicine, patient cures substantially, and during drug administration, have no adverse reaction generation, illustrates that medicine of the present invention has no side effect substantially to human body.Above-mentioned patient continues to take medicine of the present invention, and most of patient fully recovered 7-12 the course for the treatment of, and follow-up investigation display, the relapse rate of recovery from illness patient in 2 years is lower than 3%.
Claims (6)
1. treat a dermopathic Chinese medicine composition, it is characterized in that being made up of the raw material of following weight portion: Caulis Vernoniae andersonii 30 ~ 60 parts, Fructus Psoraleae 30 ~ 60 parts, Radix Angelicae Sinensis 15 ~ 30 parts, processed with wine Fructus Schisandrae Chinensis 10 ~ 20 parts, Radix Plumbaginis Zeylanicae 10 ~ 20 parts, Rhizoma Bistortae 8 ~ 20 parts, Radix Saposhnikoviae 9 ~ 18 parts, Rhizoma Chuanxiong 9 ~ 18 parts, Rhizoma Dioscoreae Hypoglaucae 16 ~ 32 parts.
2. Chinese medicine composition according to claim 1, is characterized in that being made up of the raw material of following weight portion: Caulis Vernoniae andersonii 36 parts, Fructus Psoraleae 36 parts, Radix Angelicae Sinensis 18 parts, processed with wine Fructus Schisandrae Chinensis 18 parts, Radix Plumbaginis Zeylanicae 12 parts, Rhizoma Bistortae 10 parts, Radix Saposhnikoviae 10 parts, Rhizoma Chuanxiong 12 parts, Rhizoma Dioscoreae Hypoglaucae 20 parts.
3. Chinese medicine composition according to claim 1 and 2, is characterized in that: dosage form is tablet, capsule, pill, granule.
4. treat a dermopathic Chinese medicine composition, it is characterized in that being made up of the raw material of following weight portion: Caulis Vernoniae andersonii 36 parts, Fructus Psoraleae 36 parts, Radix Angelicae Sinensis 18 parts, processed with wine Fructus Schisandrae Chinensis 18 parts, Radix Plumbaginis Zeylanicae 12 parts, Rhizoma Bistortae 10 parts, Radix Saposhnikoviae 10 parts, Rhizoma Chuanxiong 12 parts, Rhizoma Dioscoreae Hypoglaucae 20 parts, Radix Rehmanniae 28 parts, Radix Cynanchi Atrati 8 parts, Cortex Moutan 20 parts.
5. a preparation method for the dermopathic Chinese medicine composition for the treatment of according to claim 1, is characterized in that comprising the following steps:
(1) Caulis Vernoniae andersonii is ground into fine powder, for subsequent use;
(2) remaining crude drug is mixed, with the ethanol extraction 2 ~ 3 times of 6 ~ 12 quality, 65 ~ 80vol% doubly, merge extractive liquid;
(3) extracting solution is condensed into clear paste or the thick paste that 60-80 DEG C of relative density is 1.20 ~ 1.40;
(4) clear paste, Caulis Vernoniae andersonii fine powder are mixed with the adjuvant of survival dose, make the Chinese medicine composition of required dosage form.
6. the application of the dermopathic Chinese medicine composition for the treatment of according to claim 1 in preparation treatment vitiligo and psoriasis.
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| CN103830379A (en) * | 2014-03-03 | 2014-06-04 | 新疆吐鲁番地区维吾尔医医院 | Blood purifying mixture for treating skin diseases |
| CN106063870A (en) * | 2016-08-17 | 2016-11-02 | 施泽晶 | A kind of Chinese medicine composition treating damp abundance due to splenic asthenia type dermatitis and preparation method thereof |
| CN117618318B (en) * | 2023-12-07 | 2024-05-24 | 广东尤发生物科技有限公司 | Disposable massage cream and preparation method thereof |
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| 中药激活黑素细胞作用和治疗白癜风有效性的机理探讨;马建龙;《内蒙古中医药》;20080223(第04期);32 * |
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