CN1029082C - Multipharmaceutical syringe - Google Patents

Abstract

A multiple cartridge syringe, especially useful for use in dispensing insulin, includes a body housing first and second pharmaceutical-filled cartridges. The cartridges are of the type with a septum at one end and a piston at the other end with the liquid pharmaceutical between the two. The body also defines an accumulator chamber within which an accumulator piston is slidably mounted. When the cartridges are mounted within the body, the septums are pierced by hollow spikes which are connected to a flow path opening into the accumulator chamber. Check valves are used at the distal ends of the spikes to prevent liquid flow back into the cartridges. Pressing on the cartridge pistons forces the liquids into the accumulator chamber. Once the desired amounts of both liquids are in the accumulator chamber, the needle assembly is moved to its extended position which fluidly couples the needle to the accumulator chamber. The injection is given by driving the accumulators piston using the stem.

Description

Multipharmaceutical syringe

The present invention relates to cartridge syringe, relate to one kind of multiple cartridge syringes particularly, be used for injecting particularly insulin mixture of multiple medicament mixed liquid.

Medical islets of langerhans have three kinds of fundamental types: fugitive, middle effect and long-acting.The mixed liquor that the insulin user usually adopts two types of insulins according to the suction situation and the predetermined activity schedule of its blood glucose amount, the Time of Administration of every day, nutrition.For example, when start insulin injection a working day, can use more short-acting insulin, and when the insulin injection just before going to bed that closed to an end in a day, then preferably use more middle effect or protamine zine insulin.

One of problem of common insulin syringe is can only inject one type insulin and the mixed liquor that can not inject multiple insulin.Though also can buy the mixed liquor of two types of insulins, the component of this mixed liquor is fixed often, for example imitate in 70% add 30% fugitive.Therefore, prior art is limiting the mixed liquor that the insulin user uses two kinds of predetermined insulins, perhaps must carry out double injection respectively.

The objective of the invention is to overcome the problem that prior art exists, a kind of syringe that uses common medication tube more than two is provided, it can allow usefulness person's amount and ratio in every kind of required medicine when a shot discharge medicinal liquid from common fluid reservoir.For example, it can make the insulin user select the amount and the ratio of two kinds of insulins injecting in the shot arbitrarily.

This multitube syringe contains a housing of settling first and second drug liquid tubes.Described liquid pipe is preferably a kind of at one end barrier film, and the other end has the piston of exposure, and the liquid pipe of medicinal liquid is arranged between this two.Also have a fluid reservoir in the housing, the liquid storage piston of a slip is arranged in the fluid reservoir.In one embodiment, the near-end of housing is an opening, so that respectively three pistons are pushed in the pipe with a bar.Then be that each liquid pipe piston and liquid storage piston respectively have its drive rod in another embodiment.Their barrier film is all pierced through by hollow minute hand respectively, and hollow needle is communicated with the runner that leads to the fluid reservoir far-end.The common the most handy check valve of far-end at minute hand is so that make the medicinal liquid in each liquid pipe by minute hand effluent pipe adverse current not take place.

Piston in the pushing liquid pipe makes liquid pipe inner liquid medicine by minute hand and check valve, and the longshore current road flows into fluid reservoir.The far-end that the increase of fluid reservoir internal pressure and amount of liquid medicine forces the liquid storage piston to leave fluid reservoir is shifted to the near-end of housing.Till liquid pipe piston is worked separately that two kinds of required medicinal liquids are pressed into fluid reservoir and is mixed in fluid reservoir.

Then, the nozzle needle assembly is communicated with fluid reservoir.In one embodiment, this point is to finish by the nozzle needle assembly is moved on to extended position from its common stored position or stowed position.So just make the far-end of fluid reservoir realize that with hollow nozzle needle fluid is communicated with.The bar that pushing is connected with the liquid storage piston forces the interior new blended medicinal liquid of fluid reservoir to flow through hollow nozzle needle.In case injection is finished, the nozzle needle assembly is just retracted its stowed position.This is not only nozzle needle is moved on to the intravital home of shell, and nozzle needle and fluid reservoir are isolated.

The most handy bar once promotes a piston.Can come cramp bar with an end cap that is installed to the near-end of housing slidably.When bar promoted each piston, end cap was carried out guiding to bar.After pulling out piston from housing, end cap can lateral sliding so that make the far-end of bar aim at another piston.

The medicinal liquid of the not commensurability and ratio of two or more that the present invention is characterized in that its available simple small syringe shot is required.In addition, the present invention is designed to adopt common drug liquid tube to reduce cost, and increases motility, for insulin provides a kind of flexible, light and compact syringe with the person, use this syringe, in a shot, can inject the insulin of required any ratio.

Though above-mentioned syringe is a kind of reusable design,, it also is easy to become disposable syringe, as long as do not take off end cap and do not change one or both consumptive drug liquid tubes with the person.

The fluid reservoir piston can be made and have a folding aseptic overskirt that is connected with the fluid reservoir near-end, and this will help guaranteeing that fluid reservoir in use or the aseptic between twice use.

The size of fluid reservoir preferably syringe not the time spent can put into whole bar fully, like this, add the liquid pipe and become several rows of row with fluid reservoir, can make syringe become very compact, and it can be put in the quite solid bag.The optimum configuration of this syringe has reduced or has eliminated shortcoming when using common hypodermic syringe and medicine bottle.

The present invention can make such structure, and promptly its check valve is removable with connecting adapter runner inner and fluid reservoir and hollow nozzle needle, and this just makes most of syringes reusable, thereby has increased aseptic degree for reduce expense with the person.In a most preferred embodiment, this point leans against on the housing installs a removable runner liquid pipe and realizes that this removable runner liquid pipe contains the runner element from minute hand, and described minute hand pierces through barrier film on the liquid pipe by fluid reservoir.

Another feature of the present invention is to be provided with a kind of medication dosing device.For this reason, be with externally threaded bar for the most handy one, it is driven by the hollow drive rod that an end has female thread, and hollow drive rod then can be by rotating with the person.Above-mentioned threaded drive rod is preferably with ratchet, can be braked, and distributes hearing and tactile information of next amount of liquid medicine so that provide from each liquid pipe.Be with externally threaded bar to reset (this is compulsory when changing the liquid pipe) with respect to tapped drive rod in order to make, the most handy locking collar will be so that will be with externally threaded bar to be fixed to tapped driving rod end selectively.Like this,, screw thread is thrown off, threaded bar is resetted in hollow drive rod by moving the locking collar.

The present invention also can make and use a kind of indicator clearly visually, is used for visual plunger the moving in drug liquid tube of measuring, and distributes the amount of liquid medicine of coming thereby measure from each liquid pipe.This most handy one sensing element that can experience the rotation of threaded drive rod and show the vision indication, for example, with a kind of can be with the successive loops of the mobile amplification of piston, in other words, if piston moves the medicinal liquid that 0.84mm distributes a pharmaceutical units, so the loop index strip removable should distance twice or more than the twice.This hyperplastic distance helps the relatively poor person of using of vision especially from indication.Injection can be reset dosage indicator with the person once or several times.

By describing most preferred embodiment in detail below in conjunction with accompanying drawing, other features and advantages of the present invention will be clearer, in the accompanying drawing:

Fig. 1 is the isometrical drawing of syringe of the present invention;

Fig. 2 is the side view of syringe of the present invention, shows the Position Control button of nozzle needle assembly;

Fig. 3 is the end-view of syringe of the present invention, and the finger pressure surface of push rod is shown;

Fig. 4 is the cross-sectional view along the 4-4 line of Fig. 2;

Fig. 5 is the cross-sectional view of Fig. 4 syringe, and its end cap is mobile, and plunger promoting the first piston of the first liquid pipe, forces first kind of medicinal liquid to enter fluid reservoir;

The end cap that Fig. 6 illustrates the syringe of Fig. 5 has moved on to another position, and bar is connected with second piston of the second liquid pipe, forces second kind of medicinal liquid to enter fluid reservoir, and mixes with first kind of medicinal liquid in fluid reservoir;

Fig. 7 is the zoomed-in view that Fig. 6 syringe is cut open along the 7-7 line;

The syringe tip cap of Fig. 8 presentation graphs 6 has been moved back into the position of Fig. 4, and the nozzle needle assembly is positioned at extended position and needle shield takes down, and bar begins to drive the liquid storage piston forces admixing medical solutions to flow out fluid reservoir also by hollow nozzle needle;

Fig. 9 illustrates the syringe of Fig. 8, and after admixing medical solutions was discharged, the nozzle needle assembly had been withdrawn and put the state behind the protective sleeve;

Figure 10 A and Figure 10 B are the front view of transparent meter label;

Figure 11 A and Figure 11 B show the sketch of the liquid storage piston of Fig. 4 of having aseptic overskirt and Fig. 5;

Figure 12 is the cross sections figure of another embodiment of Fig. 4 syringe, is in the preceding state that uses;

Figure 12 A is the outer end of Figure 12 syringe or the zoomed-in view of far-end;

Figure 12 B is the zoomed-in view of the near-end of Figure 12 syringe;

Figure 13～15 are respectively side, near-end and the distal end view of Figure 12 syringe; The finger pressure drive rod of expression fluid reservoir has forwarded hatched use location among Figure 13 to;

Figure 16 is the exploded cross section views of Figure 12 syringe;

Figure 17 is the manifold base of Figure 16 and the isometric drawing of fluid reservoir assembly;

Figure 18 is the isometric drawing of the manifold cap of Figure 16;

Figure 19 is the cutaway view along the 19-19 line of Figure 18, and for the sake of clarity, the degree of depth of passage has been exaggerated;

Figure 20 is the isometric drawing of the various check valves of Figure 16;

Figure 21 is the profile along the 21-21 line of Figure 20;

Figure 22 is the amplification cross-sectional view of the removable runner liquid pipe of Figure 12, and with the form of amplifying the manifold check valve is shown and moves to dotted line position from it at the solid line position of Figure 12 and 12A, thereby has opened relevant liquid pipe inside and the runner between the fluid reservoir;

Figure 23 is that the transparent meter label of Figure 13 A decomposes the isometric projection sketch with relevant drive rod part together;

Framework, indicator band and driven member that Figure 24 illustrates Figure 23 are in assembled state;

Figure 25 is the simplification cross-sectional view of structure of the relevant drive rod of connection of an expression Figure 24; With

Figure 26～28 are to use simplification front view, side view and the end-view of arrestment mechanism of the drive rod of Figure 16.

Referring to Fig. 1～3, multitube syringe 2 contains housing 4, and first and second Room 6,8 and the fluid reservoirs 10 are arranged in the housing.The housing 4 usefulness transparent plastic compatible with medicine for example polypropylene or acrylic plastics made.Its near-end 12 usefulness one slip end cap 14 covers, thereby has covered the open proximal 16,18 of chamber 6,8.End cap 14 has an opening 20 that allows bar 22 pass through.As shown in Figure 4, the far-end 24 of bar 22 is usually located near the position that is contained in the piston 26 in the fluid reservoir 10, and referring to Fig. 5, piston 26 is positioned at the far-end 28 of fluid reservoir 10.

The size of chamber 6,8 matches with the first and second common drug liquid tubes 30,32, and liquid pipe 30,32 has the cylinder 34,35 that has a kind of barrier film that pierces through 36 in its far-end 38 and open proximal 40 respectively.The first and second liquid pipes 30,32 have first and second pistons 42,44 respectively, and hold first and second medicinal liquids 46,48 between barrier film 36 and piston 42,44.

The far-end 38 of the first and second liquid pipes 30,32 leans against on the check valve support plate 50. Hollow minute hand 52,53 installs to and passes support plate 50, and they have sharp tip 54, and when liquid pipe 30,32 inserted first and second Room, needle point 54 was just worn out barrier film 36.Slit cone shaped one-way valve 58,59(sees clearly Chu at Fig. 7) be contained in the outer end 60 of minute hand 52. Check valve 58,59 has and can press that arrow 64,66 directions flow but not reversible mobile slit 62 for fluid.Valve body 58 the most handy solid elastomeric materials such as silicone rubber are made, the silicone rubber of for example using Michigan State (04765) Midland Dow chemical company to sell.

Support plate 50 and check valve 58,59 are located by the end cap 68 that permanently is contained on the housing 4 with for example adhesive.End cap 68 has a runner 70, and the fluid that it can be provided between the far-end 28 of check valve 58,59 and fluid reservoir 10 is communicated with.

Housing 4 also has a guide groove 72 that has a rectangular cross section, and nozzle needle assembly 74 is slidably mounted in this guide groove 72.Nozzle needle assembly 74 also comprises the needle holder 76 of settling hollow nozzle needle 78.Make a L shaped duct 80 in the needle holder 76, be used for the near-end 82 of nozzle needle 78 is connected to along the aperture 84 of the flat side 86 of needle holder 76.Nozzle needle assembly 74 also comprises protective sleeve 88, and it is contained in versatilely outside the needle holder 76 and holds 90, pollutes in order to prevent nozzle needle 78, and prevents that people are subjected to the injury of needle point accidentally.

Needle holder 76 comprises that a button 92(who has enlarged end 94 sees Fig. 2).The size of button 92 can move it along groove 96, and the size of enlarged 94 then can engage with the enlarged 98,100 of groove 96.For with enlarged 94 expansion section 98(such as Fig. 2 and shown in Figure 4 from groove) move to enlarged 100(as shown in Figure 8), but with person's press push button 92 and nozzle needle assembly 74 is slided along the direction of the arrow 102 of Fig. 8.(cross section at label 104 places reduces to make needle holder 76 to produce a suitable resilience by a part in needle holder.When needle holder 76 was positioned at the extended position of Fig. 8, the end 106(that just aims at duct 108 towards the aperture 84 in L shaped duct 80 saw Fig. 7), thus make the far-end 28 of elongated fluid reservoir 10 realize that with hollow nozzle needle 78 fluid is communicated with.

For bar 22 is moved on to the position of Fig. 5 from the position of Fig. 4, at first bar 22 is taken out as far as possible outward from fluid reservoir 10 with the person, when bar 22 moves to the rearmost position of fluid reservoir 19, coil spring 110 pressurizeds.Then end cap 14 is moved by arrow 112 directions.When bar 22 no longer with fluid reservoir 10 in line after, but usefulness person's unstick 22, in case that bar 22 becomes with 6 pairs of first Room is punctual, spring 110 just automatically forces bar 22 to enter first Room 6, thereby helps correct axially aligning.Then, force first piston 42 move along the direction of arrow 102 in finger pressure composition surface 114 once more with the person, this is with regard to making first medicinal liquid 46 and flowing through minute hand 52, check valve 58, runner 70 and enter the far-end 28 of fluid reservoir 10.The fluid pressure of the medicinal liquid 46 in fluid reservoir 10 makes piston 26 move along the direction of arrow 116, owing to used check valve 59, can not make first medicinal liquid 46 enter the second liquid pipe 32.

After first medicinal liquid 46 of q.s was introduced into the end 28 of fluid reservoir 10, pumping rod 22 once more, and end cap 14 slides along arrow 112 directions again, up to bar 22 with till second Room 8 is aimed at.Second medicinal liquid 48 is also repeated as mentioned above operation (shown in Fig. 6 and 7) to first medicinal liquid 46, so that form a kind of admixing medical solutions 118 at the far-end 28 of fluid reservoir 10.

Then, from second Room, 8 pull rods 22, end cap 14 moves on to the position of Fig. 8 along the direction of arrow 113.And button 92 is reduced, make nozzle needle assembly 74 shift the position of Fig. 8 onto from Fig. 6 position.Take off protective sleeve 88 then, and an end that will overlap inserts in the blind storage hole 120 that is located on the end cap 68.Inject on composition surface 144 by finger pressure bar 22, makes admixing medical solutions flow through duct 108, duct 80 and hollow nozzle needle 78.

Be forced to enter the amount of medicinal liquid 46,48 of the far-end 28 of fluid reservoir 10, measure with the transparent metering label 126,128 shown in Figure 10 A and the 10B.Label 126,128 has liquid storage scale 130.Except the labelling shown in Figure 10 A and the 10B, label 126,128th, transparent, see the liquid measure of drain pipe 30,32 and fluid reservoir 10 easily.Interval between each scale 130 equals a pharmaceutical units.Label 126 also has the first and second medicine scales 132,134.Be separated by the separately distance of half pharmaceutical units of scale 132,134.Therefore, if with the person with piston 42,44 from a scale 132,134 move on to next scale 132,134, so, (pharmaceutical units of respectively doing for oneself half) medicinal liquid 46,48 of equivalent just is forced into fluid reservoir 10, makes piston 26 move a distance that equals distance between adjacent two scales 130.

When the ratio of first medicinal liquid 46 and first medicinal liquid 48 is 7: 3, then use to be installed on the housing 4 label 128 relative with label 126.Distance between the first and second medicine scales 136,138 in succession is respectively corresponding to 70% and 30% of a pharmaceutical units.Notice that adjacent scale 138 is stagger arrangement, otherwise scale is too intensive, is difficult for reading.Label 126,128 is preferably dismountable, so that also can use the graduated label of other mixed proportions.

In case injection finishes, promptly 120 take off protective sleeve 88, and restore safely above nozzle needle 78 from the duct, fall button 92, unclamp bellend 94 from enlarged 100, nozzle needle 74 is got back to the stowed position shown in Fig. 4～6.Loosen button 92 bellend 94 is engaged with groove enlarged 98 once more, stretch out once in a while to prevent the nozzle needle assembly.

Fluid-tight is carried out in end 106 with 124 pairs of ducts 108 of O shape ring, as shown in Figure 7.When nozzle needle assembly 74 is in the stowed position of Fig. 4～6; O shape ring 124 engages with the outer surface of protective sleeve 88; when the nozzle needle assembly was in the extended position of Fig. 8, O shape ring 124 was just in the flat side 86 of pressing to needle holder 76 in the zone of position 84 and 80 ends, L shaped duct.O shape that need not be independent ring, and with the sealing of other patterns also can, for example, the outward extending sealing ring of mold pressing.In addition, aseptic in order to help to accomplish, near the available check valve in O shape ring place, this is particularly useful when using detachable nozzle needle assembly.

Use the benefit in the blind storage hole 120 temporarily lay protective sleeve 88 make protective sleeve in the device use from syringe side to overhanging.Therefore, if with the person accidental forgot before the nozzle needle assembly is withdrawn into guide groove 72 just protective sleeve is replaced, so, when wanting with the person syringe is stored in its pocket, bag or takes the thing bag, protective sleeve 88 will directly hinder.And, if when piston 42,44 is depressed, protective sleeve 88 not in position, medicinal liquid will be sewed through duct 108 and be spilt outside the guide groove 72.Therefore, must correctly keep protective sleeve 88 in its original position with the person.

For convenience, establish an open-work 122, be used for carrying syringe 2, for example, can go here and there key chain by end cap 68 in the person of using.

Figure 11 A and Figure 11 B schematically illustrate a fluid reservoir 144 of laying liquid storage piston 146 aseptic overskirts 148.Overskirt 148 is a for example silicone rubber of a kind of light-duty, impermeabilisation, flexible tubular material, and one end 150 is fixed on the piston 146, and the other end 154 is fixed to the near-end 152 of fluid reservoir 144.During extreme position in piston 146 is in fluid reservoir 144, overskirt 148 just is in elongation state (Figure 11 A), and when piston 146 approached near-end 152, overskirt just was in pressured state (Figure 11 B).Therefore, overskirt 148 and piston 146 help in use and use between keep the inwall of fluid reservoir 144 aseptic.Also available other method guarantees aseptic.

Figure 12～16 illustrate an alternative embodiment of the invention.Syringe 160 has a housing 162, and first, second and the 3rd Room 164,166,168 are arranged in it.First and second Room, 164,166 usefulness round flanges 178,180 are separated into far-end 170,172 and near-end 174,176.The size of far-end 170,172 can match with first and second drug liquid tubes 182,184.The diameter of liquid pipe 182 and volume ratio liquid pipe 184 are big, and usually, the former is 3ml, and the latter is 1.5ml.Liquid pipe 182,184 is fixed on manifold base and fluid reservoir assembly 186(sees Figure 17) on.Assembly 186 has sharp hollow needle 188, is used for puncturing the barrier film of liquid pipe 182,184.Liquid pipe 182,184 is fixed on the assembly 182 by the joint of the boss 192 that extends internally from jaw 194, and four jaws 194 surround each prong 188 with respect to the flange of closely facing 196 of collar 198.Assembly 186 also has a piston 200 that constitutes fluid reservoir 202, and this piston 200 is contained in the 3rd Room 168 of housing 162.

Assembly 186 has a cylindrical extension 204, and it is installed in the blind hole of the complementary shape of making on the elastomer manifold check valve 208 closely, sees Figure 17 and 22.Preferably a kind of hardness of check valve 208 is 50 rubber, silicone rubber for example, and it has a pair of extension 210 that respectively carries cylindrical outer surface and circular cone inner surface 212.The size of this extension 210 will make it and be located at tapered opening 214 complementary fit in the assembly 186.When load module 186 and manifold check valve 208, extension 210 and engaging of tapered opening 214 are played the effect of check valve, and cylindrical extension 204 then is contained in the blind hole 206 closely.

With adhesive or ultrasonic bond technology manifold cap 216 is fixed on the assembly 186 along its phase cross surface 218, sees Figure 22.This just is fixed on manifold check valve 208 between assembly 186 and the manifold cap 216 tightly, thereby makes on manifold check valve 208 the 220 pairs of assemblies 186 of annulus sealing that form that tightly sealing is provided.Manifold cap 216 has one to be generally the passage 222 that 3.2mm is wide, 0.38mm is dark.A piston 224 when liquid pipe 182,184,225 are driven along the length of liquid pipe and are moved, and force a kind of medicinal liquid 226,228 by forming the member 210 of check valve 230,214 o'clock, passage 222 allowed the manifold check valve to bend in the passage (as shown in phantom in Figure 22).Subsequently, medicinal liquid is between a face 234 of face 232 of manifold check valve 208 and assembly 186, and flow between cylindrical extension 204 and the blind hole 206, by the duct 236 that in extension 204, forms, flow into fluid reservoir 202, this just makes liquid storage piston 238 edges is that direction moves shown in the arrow 240 proximad.Piston 238 has an integrally formed year bacterium overskirt 242, and it has a fixed folded part 244, by the surface portion 200 relative (see Figure 16) of sealing ring 246 with assembly 186.

Manifold cap 216 has a threaded bearing 248, and a band female thread hub shape needle stand 250 is installed on it.With a suitable epoxy spare 254 vasiform nozzle needle 252 is fixed tightly on the needle stand 250.Needle guard 250, hollow nozzle needle 252 and epoxy spare 254 are formed nozzle needle assembly 262, are contained in the oversheath 264, and this nozzle needle assembly can be bought in Becton Dickenson company (New Jersey Lu Se good fortune).The detachable film band (not shown) that nozzle needle assembly 262 usefulness are a kind of to be fixed on the flange 266 of sheath 264 is sealed in the sheath 264.

It is one sharp inner 256 that nozzle needle 252 has, and when nozzle needle assembly 262 installed to bearing 248, it punctured that part of 258 of the manifold check valve 208 that covers blind hole 206 ends.This step is to carry out after needed medicinal liquid 226,228 mixed liquors have been stored in chamber 202, sees Figure 16.For the purpose of safety and health, pin 252 is overlapping with cover 260 usually.Nozzle needle assembly 262 and sheath 264 remove after each the use usually.Sheath 264 not only is used for protecting nozzle needle assembly 262 not to be damaged and pollutes, and is used for metering from liquid pipe 182,184 and the medicinal liquid 226,228 that enters fluid reservoir 202, and this point will describe in detail below.

Referring to Figure 16.Piston 224,225 is driven by the bar assembly 268,270 that is placed in the near-end 174,176.Bar assembly 268,270 is with externally threaded bar 272,274, and its size just in time matches with hollow drive rod 276,278.Drive rod 276,278 has female thread 280,282, cooperates with the external screw thread 284,286 that forms along bar 272,274 total lengths basically.The far-end 288,290 of drive rod 276,278 has 4 slits 292 establishing within it.This slit 292 can make far-end open in 288,290 minutes, so that make bar 272,274 rotate and move axially in drive rod 276,278 by cooperatively interacting of screw thread.Bar assembly 268,270 is locked the collar 294,296 in addition, and the outside of its size and drive rod 276,278 matches.Shown in Figure 13 B and 13C, the button 298 that the locking collar 294 usefulness one are installed in the opening 300 that forms on the housing 162 comes axial location.A pair ofly pass groove 304,306 from 298 pins that go out 302 of button and engage with the locking collar 294,296.By handling axially movable button 298, can make the locking collar 294,296 from topped far-end 288, the locked position of Figure 12 of 290 moves on to the position with respect to the right of Figure 12, thus at bar 272,274 from drive rod 276,278 pull out or push drive rod 276,, make far-end 288,290 expansions at 278 o'clock.

Drive rod 276,278 can freely rotate in near-end 174,176, but be clamped in their the insides by yoke 308, and yoke 308 usefulness screws 312 are fixed on the near-end 310 of housing 162, and it has a pair of arcuate openings 314, be in the scope of the circular trough 316 on the near-end 314 of drive rod 276,278.Near-end 318 has an outer surface 320 that ratchet is arranged.Spring wire 322,324 is contained in the hole 326 of groove 328,330 ends.Groove 328,330 has been made an angle, so that spring wire 322,324 compresses the outer surface that ratchet is arranged 320 of drive rod 276,278.

When usefulness person's rotating drive straight 276,278 o'clock, drive rod axis was to remaining on original position, but bar 272,274 clamping pistons 224,225 respectively.Do just making medicinal liquid 226,228 enter fluid reservoir 202 like this, and driving liquid storage piston 238 moves to the right of Figure 12.Then, nozzle needle assembly 262 is installed on the threaded bearing 248, so that make the inner 256 of sharpening pierce through the part 258 of manifold check valve 208.Piston 238 (promptly proximad) to the right moves, and just makes liquid storage bar 332 shift to Figure 12 the right.This makes the pressing driven unit 334 that is contained in near-end 336 also shift to the right of Figure 12.In order to inject, prop up part 336 along arrow 338 directions (Figure 13) rotation pivot pressing, remove cover 260 then, prop up part 336 with the thumb pressing, inject.

As shown in figure 12, use oversheath 264, can be usefulness person and provided an additional mechanical benefit at 276,278 o'clock in rotation of drive rod.Near-end 318 has the opening 340 of taper, its size be can with the conical outer surface frictional engagement of oversheath 264.

Referring to Figure 13 A, 23,24 and 25, can see that syringe 160 has a visual meter indication 346 that is installed in rotation on the housing 162 below, this indicator 346 has a framework 348 that has pair of openings 350.Bearing-surface 352 and the guide groove 354 that is limited in the guide groove extension 356 are arranged in each opening 350.Article one, the continuous loop line index strip 358 that has demarcation line 360 is centered around on the whole bearing-surface 352.A driven member 362 that has a pair of groove 364 in the top is contained in the groove 354 and moves along groove.Driven member 362 has an entrainment device 366, and it can tightly clamp index strip 358 along the bottom.

Driven member 362 has tooth 368, just in time with the outer surface of drive rod 276,278 on tooth 370 engagements.Figure 16 illustrates the framework 348 that has the transparent cover 372 that is fixed on the framework.As shown in FIG. 13A, numeral 374 is arranged on the lid 372.This just makes user can clearly measure the size (usually by pharmaceutical units) of drug dose by demarcation line 360 with respect to the position of numeral 374.Preferably make driven member 362(also make demarcation line 360) with one than corresponding piston 224,225 quickly linear velocity move.In most preferred embodiment, this ratio is 2: 1, and therefore, if external screw thread 284 is 20 teeth of per inch on the bar, 370 in tooth is 10 teeth of per inch, could amplify twice.Because the distance that moves is generally less, so said mechanism is very big help to what particularly vision weakened with the person with the person.

Under the situation of the scope of the present invention that does not deviate from following claim regulation, the foregoing description also can be done other change and improvement.For example, syringe 2 can improve, with common blank pipe as fluid reservoir 10.The nozzle needle assembly can be installed on the injector housing rotationally.The nozzle needle assembly also can permanently be installed on the appropriate location.Without check valve 58,59, but piston 42,44 is only moved along a direction towards far-end 38, to prevent the anti-liquid pipe that flow back into of medicinal liquid.Syringe can be made in the occasion more than two liquid pipes and use.The present invention also can have an additional liquid pipe or liquid chamber, and the splendid attire Sterile Saline is used for washing the runner exit of hollow nozzle needle and minute hand after injection.

Claims (5)

1, a kind of syringe, the drug liquid tube that has cylindrical shell with carrying liquid uses, this cylindrical shell has an opening and one can thrust end, in the tube piston is arranged, at the tube inner carrier and can thrust a kind of medicinal liquid is arranged between the end, described syringe comprises that its shape can lay the housing of the first and second liquid pipes within it; First mechanism that can close with the thrust termination of the first and second liquid pipes is used for the inner barrel of the first and second liquid pipes is realized that with fluid reservoir fluid is communicated with; Stop fluid to flow into the interior mechanism of tube of the first and second liquid pipes; With a hollow nozzle needle; It is characterized in that also comprising

An elongated fluid reservoir;

A movable liquid storage piston that is placed in the fluid reservoir;

Make the selectively mechanism that is communicated with of fluid of hollow nozzle needle and fluid reservoir;

Be installed to the piston drive of each drug liquid tube on the housing, piston drive comprises a movable bar actuator and a bar, the bar actuator comprises a bar driving element, this bar has a near-end and a far-end, far-end engages with piston, bar driving element and bar are done to drive to be connected and are made the motion decision of bar driving element be applied to the amount of axial movement on the bar, and by means of the bar driving element, piston determines how many medicinal liquids are pressed into fluid reservoir in drug liquid tube;

The bar assembly that can engage with the liquid storage piston, by this bar assembly, the admixing medical solutions in fluid reservoir can be flow through the mechanism of above-mentioned selectively fluid connection and flow through above-mentioned hollow nozzle needle by pressurized.

According to the syringe of claim 1, it is characterized in that 2, the mechanism of above-mentioned prevention fluid flow comprises the check valve of each described first and second liquid pipe.

According to the syringe of claim 1, it is characterized in that 3, described fluid reservoir has a far-end and a near-end, and the bar assembly comprises a liquid storage bar that stretches out from this near-end.

According to the syringe of claim 1, it is characterized in that 4, described housing has the structure division that can make user observe liquid pipe and fluid reservoir.

According to the syringe of claim 1, it is characterized in that 5, this syringe also contains the scale that is engraved on the above-mentioned housing, so that allow user tolerance be pressed into the amount of the medicinal liquid of fluid reservoir from the liquid pipe.

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