CN102895600A - Pharmaceutical composition for treatment of varicosity and preparation method thereof - Google Patents
Pharmaceutical composition for treatment of varicosity and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a pharmaceutical composition for treatment of varicosity and a preparation method thereof. The pharmaceutical composition comprises 3-80 parts of saffron crocus by weight, 3-80 parts of olibanum by weight, 3-80 parts of myrrh by weight, 3-60 parts of radix rehmanniae by weight, 3-60 parts of radix sophorae flavescentis by weight, 6-100 parts of sangusis draconis by weight, 6-100 parts of leech by weight, 3-80 parts of leonurus by weight, 3-80 parts of waxgourd peel by weight, 3-100 parts of eupolyphaga by weight, 80-200 parts of murraya paniculata by weight, 3-80 parts of ligusticum wallichii by weight, 3-80 parts of pyrola by weight, 3-50 parts of teucrium viscidum by weight, 3-60 parts of curcuma zedoary by weight, 1-30 parts of madder, 30-80 parts of buddleja asiatica by weight, 3-60 parts of radix angelicae pubescentis by weight, 3-60 parts of cinnamon by weight, 3-100 parts of lysimachia nummularia by weight, 3-100 parts of tetrapanax papyriferus by weight, 3-80 parts of codonopsis pilosula by weight, 3-30 parts of angelica sinensis by weight, 1-30 parts of pseudo-ginseng and optional pharmaceutically acceptable excipients.
Description
Technical field
The present invention relates to a kind of pure Chinese medicinal preparation, relate in particular to a kind of cirsoid Chinese medicine preparation for the treatment of.
Background technology
Varicosis is a kind of frequently-occurring disease of common veins of lower extremity projection, and sickness rate is high, shows according to Chinese disease surveillance center monitors, and 11.6% Chinese suffer from angiopathy around in various degree varicosis, vasculitis, the phlebitis etc.At China's Hospital: per hour because suffering from varicosis, have 3 teachers will take leave of the dais; Have 350 sales counter shop-assistants will lose the job post because suffering from vasculitis, phlebitis every day; There are 1600 soldiers, police, security personnel more to change jobs because suffering from varicosis per month; In China, there are every year 3800000 labourers that stand to suffer from " foul disease " that varicosis, vasculitis, phlebitis etc. often are considered to " amputation " signal; It is high that numeral shows that China's peripheral angiopathy enters particularly 28 years old-55 years old outbreak period age bracket sickness rate in advance, and mostly be the good men and women of at life's full flowering sign, in case morbidity gently then impact is physically and mentally healthy, heavy then cause pain, swelling, the sense of heaviness difficulty of walking, skin blackout, vasculitis, phlebothrombosis, limbs fester, and treat to cause amputation untimely late period, cause the great economy burden to have a strong impact on quality of life to the patient; Not only China is like this, and peripheral angiopathy also is a world-famous puzzle that allows the medical expert feel simply helpless in the world.According to WHO(World Health Organization (WHO)) up-to-date " global peripheral vascular disease report " disclosure: wreak havoc in the whole world in recent years as main peripheral angiopathy take thromboangiitis obliterans and varicosis, seize 500,000 human lives and 3,000,000 shanks every year.The home and abroad there is no specific drug and the technology for the treatment of varicosis, vasculitis and complication non-operative treatment at present;
The cirsoid method of existing treatment mainly contains:
1, oral drugs have greatly side effect to gastric irritation, and cure rate is low that recurrence arranged more;
2, injection sealing differential hardening agent injection, sealing blood vessels, this way relapse rate of clinical proof is high, and complication is many;
3, folk prescription among the people--have some patient to take folk prescription in clinical and fail to respond to any medical treatment, the best treatment of result is missed period, the middle and advanced stage that the state of an illness is incured loss through delay the poling refractory and healed;
4, operative treatment, generally be to utilize modern technologies, operation to destroy merely or extract original vein at present, clinical proof operative treatment misery is larger, lower limb had sense of heaviness when walking appearred in the 2-3 most of patients after the operation, minority is with pain, and relapse rate is high, expense is high, make the patient endlessly sad;
5, cirsoid other Chinese medicine preparation for the treatment of is also arranged, and method is comparatively complicated; At present the home and abroad yet there are no with the pure Chinese powder medicine external application special for treating varicosis report of rehabilitation at short notice.
Therefore, for cirsoid treatment, also need more safely and effectively medicine and method.
Summary of the invention
The object of the invention is to provide a kind of powder of pure Chinese medicine, is used for the treatment of varicosis, and application method is external application, the zero distance medication, and directly to focus, no pain, zero injures, repairing performance is strong, cure rate is high, environmental protection is not recurred.
The invention provides a kind of cirsoid pharmaceutical composition that is used for the treatment of, comprising:
Stigma Croci 3-80 weight portion, Olibanum 3-80 weight portion, Myrrha 3-80 weight portion, Radix Rehmanniae 3-60 weight portion, Radix Sophorae Flavescentis 3-60 weight portion, Sanguis Draxonis 6-100 weight portion, Hirudo 6-100 weight portion, Herba Leonuri 3-80 weight portion, Exocarpium Benincasae 3-80 weight portion, Eupolyphaga Seu Steleophaga 3-100 weight portion, Folium Et Cacumen Murrayae 80-200 weight portion, Rhizoma Chuanxiong 3-80 weight portion, Herba Pyrolae 3-80 weight portion, Herba Chenopodii Hybridi 3-50 weight portion, Rhizoma Curcumae 3-60 weight portion, Radix Rubiae 1-30 weight portion, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 30-80 weight portion, Radix Angelicae Pubescentis 3-60 weight portion, Cortex Cinnamomi 3-60 weight portion, Herba Lysimachiae 3-100 weight portion, Medulla Tetrapanacis 3-100 weight portion, Radix Codonopsis 3-80 weight portion, Radix Angelicae Sinensis 3-30 weight portion and Radix Notoginseng 1-30 weight portion, and optional pharmaceutically useful adjuvant.This pharmaceutical composition can effectively be treated varicosis, no pain, and through affected part, cure rate is high.
In preferred embodiment, described pharmaceutical composition comprises Stigma Croci 15-30 weight portion, Olibanum 15-30 weight portion, Myrrha 15-30 weight portion, Radix Rehmanniae 15-25 weight portion, Radix Sophorae Flavescentis 15-25 weight portion, Sanguis Draxonis 25-35 weight portion, Hirudo 25-35 weight portion, Herba Leonuri 15-30 weight portion, Exocarpium Benincasae 15-30 weight portion, Eupolyphaga Seu Steleophaga 40-60 weight portion, Folium Et Cacumen Murrayae 80-90 weight portion, Rhizoma Chuanxiong 15-30 weight portion, Herba Pyrolae 15-30 weight portion, Herba Chenopodii Hybridi 10-20 weight portion, Rhizoma Curcumae 15-30 weight portion, Radix Rubiae 5-10 weight portion, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 30-50 weight portion, Radix Angelicae Pubescentis 15-30 weight portion, Cortex Cinnamomi 15-30 weight portion, Herba Lysimachiae 20-50 weight portion, Medulla Tetrapanacis 20-50 weight portion, Radix Codonopsis 15-30 weight portion, Radix Angelicae Sinensis 15-25 weight portion and Radix Notoginseng 5-10 weight portion, and optional pharmaceutically acceptable auxiliaries.For different patients, according to the concrete condition of its four methods of diagnosis, can finely tune medicament contg, but not exceed in above-mentioned content and the proportion.
In preferred embodiment, the described medicinal residues of Folium Et Cacumen Murrayae described in the cirsoid pharmaceutical composition for obtaining after the above Chinese liquor of bubble 55 degree that are used for the treatment of.Those skilled in the art can rule of thumb soak Folium Et Cacumen Murrayae according to this area conventional means.Folium Et Cacumen Murrayae: the immersion part by weight of Chinese liquor can be preferably 1:1 to 1:6, more preferably 1:4.
In preferred embodiment, further comprise the medicated wine that obtains by soaking Folium Et Cacumen Murrayae.
In further preferred embodiment, the described amount that is used for the treatment of medicated wine described in the cirsoid pharmaceutical composition is 60 to 70 weight portions.
The present invention also provides a kind of cirsoid pharmaceutical composition that is used for the treatment of, and is prepared as raw material by the compositions that comprises the following traditional Chinese medicines material and pharmaceutically useful adjuvant:
Stigma Croci 3-80 weight portion, Olibanum 3-80 weight portion, Myrrha 3-80 weight portion, the Radix Rehmanniae-60 weight portion, Radix Sophorae Flavescentis 3-60 weight portion, Sanguis Draxonis 6-100 weight portion, Hirudo 6-100 weight portion, Herba Leonuri 3-80 weight portion, Exocarpium Benincasae 3-80 weight portion, Eupolyphaga Seu Steleophaga 3-100 weight portion, Folium Et Cacumen Murrayae 80-200 weight portion, Rhizoma Chuanxiong 3-80 weight portion, Herba Pyrolae 3-80 weight portion, Herba Chenopodii Hybridi 3-50 weight portion, Rhizoma Curcumae 3-60 weight portion, Radix Rubiae 1-30 weight portion, the little 30-80 weight portion of reviving after death, Radix Angelicae Pubescentis 3-60 weight portion, Cortex Cinnamomi 3-60 weight portion, Herba Lysimachiae 3-100 weight portion, Medulla Tetrapanacis 3-100 weight portion, Radix Codonopsis 3-80 weight portion, Radix Angelicae Sinensis 3-30 weight portion, Radix Notoginseng 1-30 weight portion.For different patients, according to the concrete condition of its four methods of diagnosis, can finely tune medicament contg, but not exceed in above-mentioned content and the proportion.
One preferred embodiment in, described raw material comprises Stigma Croci 15-30 weight portion, Olibanum 15-30 weight portion, Myrrha 15-30 weight portion, Radix Rehmanniae 15-25 weight portion, Radix Sophorae Flavescentis 15-25 weight portion, Sanguis Draxonis 25-35 weight portion, Hirudo 25-35 weight portion, Herba Leonuri 15-30 weight portion, Exocarpium Benincasae 15-30 weight portion, Eupolyphaga Seu Steleophaga 40-60 weight portion, Folium Et Cacumen Murrayae 80-90 weight portion, Rhizoma Chuanxiong 15-30 weight portion, Herba Pyrolae 15-30 weight portion, Herba Chenopodii Hybridi 10-20 weight portion, Rhizoma Curcumae 15-30 weight portion, Radix Rubiae 5-10 weight portion, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 30-50 weight portion, Radix Angelicae Pubescentis 15-30 weight portion, Cortex Cinnamomi 15-30 weight portion, Herba Lysimachiae 20-50 weight portion, Medulla Tetrapanacis 20-50 weight portion, Radix Codonopsis 15-30 weight portion, Radix Angelicae Sinensis 15-25 weight portion and Radix Notoginseng 5-10 weight portion, and optional pharmaceutically acceptable auxiliaries.
Preferably, describedly be used for the treatment of cirsoid pharmaceutical composition, further comprise the medicated wine that obtains by soaking Folium Et Cacumen Murrayae.Described medicated wine is preferably 60 to 70 weight portions.
The present invention also provides a kind of method for the preparation of the cirsoid pharmaceutical composition for the treatment of, comprising:
Adopt Stigma Croci 3-80 weight portion, Olibanum 3-80 weight portion, Myrrha 3-80 weight portion, Radix Rehmanniae 3-60 weight portion, Radix Sophorae Flavescentis 3-60 weight portion, Sanguis Draxonis 6-100 weight portion, Hirudo 6-100 weight portion, Herba Leonuri 3-80 weight portion, Exocarpium Benincasae 3-80 weight portion, Eupolyphaga Seu Steleophaga 3-100 weight portion, Folium Et Cacumen Murrayae 80-200 weight portion, Rhizoma Chuanxiong 3-80 weight portion, Herba Pyrolae 3-80 weight portion, Herba Chenopodii Hybridi 3-50 weight portion, Rhizoma Curcumae 3-60 weight portion, Radix Rubiae 1-30 weight portion, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 30-80 weight portion, Radix Angelicae Pubescentis 3-60 weight portion, Cortex Cinnamomi 3-60 weight portion, Herba Lysimachiae 3-100 weight portion, Medulla Tetrapanacis 3-100 weight portion, Radix Codonopsis 3-80 weight portion, Radix Angelicae Sinensis 3-30 weight portion and Radix Notoginseng 1-30 weight portion are as raw material
By above-mentioned weight proportion powder is made in various Chinese crude drug Preparation process grindings, then fully mixed;
Wherein said Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) soaks to dry afterwards with Chinese liquor and grinds; And
Wherein said Folium Et Cacumen Murrayae is that the medicinal residues after steeping in wine dry and grind.These treatment process of steeping in wine have guaranteed the shelf-life of medicine.Wherein the weight ratio of Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) and Chinese liquor can rule of thumb be determined by those skilled in the art, and preferably soaking the Chinese liquor of Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) and the weight ratio of Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) is 1:1 to 1:6, preferred 1:4.
Preferably, the weight ratio of described Folium Et Cacumen Murrayae and Chinese liquor is 1:1 to 1:6, preferred 1:4.
In preferred embodiment, described method further comprises the step of the medicated wine modulation that described powder is obtained with the immersion Folium Et Cacumen Murrayae.With powder of the present invention with described medicated wine according to 1:1 to 1:6, preferred 1:1 to 1:4, more preferably the part by weight furnishing thick paste of 1:1.2.
The present invention also provides the pharmaceutical composition of aforesaid method preparation.
The present invention be record prescription reach the treatment varicosis of grasping 777 after effective outside coating method, the present invention is through groping, studying for many years, through clinical verification, therapeutic process is simple, no pain zero injury, the special effect cure rate is high, does not recur the low pure Chinese medicinal preparation of expense.
Designing requirement the present invention reaches following therapeutic effect: qi and blood circulation promotion, the meridian dredging, and hard masses softening and resolving, Xuemaitong need not additional any treatment means, safety and environmental protection pure Chinese medicinal preparation; Therapeutic process is simple, and do not have an injection and do not take medicine, do not affect work, study, life, zero distance medication directly to focus, no pain zero injury, one-time cure does not recur.
Patent clinical therapeutic efficacy of the present invention is as follows: this preparation have repair because of pachylosis that varicosis, vasculitis, phlebothrombosis cause, fester, cicatrix, a medication 3-7 days pain symptom disappears substantially, medication on foot sense of heaviness disappearance in 15 days to 30 days, the basic recovery from illness in 30 days of common disease, the heavier patient's medication of the state of an illness was fully recovered in 45 days to 60 days, did not recur to have no side effect.
The specific embodiment
The following term that uses in this description has implication hereinafter described.Except as otherwise noted, all scientific and technical terminologies used herein have the implication identical with the common understanding of those of ordinary skills.
For realizing the object of the invention, technical solution of the present invention is as follows:
The present invention contains 24 kinds of Chinese crude drug preparations and makes external pulvis, forms with adjuvant, it is characterized in that this external preparation contains the pure Chinese medicine of the drug weight percentage ratio of 40%-70%, and the outer time spent adds medicine ethanol in this powder; 24 kinds of Chinese crude drugs are as follows: Stigma Croci, Olibanum, Myrrha, the Radix Rehmanniae (Radix Rehmanniae), Radix Sophorae Flavescentis, Sanguis Draxonis, Hirudo, Herba Leonuri, Exocarpium Benincasae, Eupolyphaga Seu Steleophaga, Folium Et Cacumen Murrayae, Rhizoma Chuanxiong, Herba Pyrolae (Pyrola rotundifolia ssp.chinensis), Herba Chenopodii Hybridi, Rhizoma Curcumae, Radix Rubiae, little reviving after death (Herba Gendarussae (Caulis et Folium Gendarussae vulgaris)), Radix Angelicae Pubescentis, Cortex Cinnamomi, Herba Lysimachiae (BIANDIXIANG), Medulla Tetrapanacis, Radix Codonopsis, Radix Angelicae Sinensis, Radix Notoginseng; By said ratio powder is made in various Chinese crude drug Preparation process grindings, with medicated wine furnishing paste dormant various compositions are activated, directly spread on the affected part and wrap up with gauze bandage, 15 days drug effect phases.
The clinical good effect of the present invention:
Have through clinical verification preparation of the present invention and to attack long-pending, reparation, infiltration, Yin Yang balancing, enter the strong characteristics of inner absorbability, can promote local cells to organize new old generation to let out, can dissolve rapidly and remove phlebothrombosis and venous blood tube wall deposition residues, can activate cells of vascular wall reparation wall film, can repair and protrude Superficial veins, life, recovery skin true qualities by Yin Yang balancing, varicosis and complication are had magical curative effect.
Clinical therapeutic efficacy of the present invention is as follows: this preparation have repair because of pachylosis that varicosis, vasculitis, phlebothrombosis cause, fester, cicatrix, a medication 3-7 days pain symptom disappears substantially, medication on foot sense of heaviness disappearance in 15 days to 30 days, the basic recovery from illness in 30 days of common disease, the heavier patient's medication of the state of an illness was fully recovered in 45 days to 60 days, did not recur to have no side effect.
Stigma Croci, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain are warm in nature in the preparation of the present invention, enter the heart, Liver Channel; Olibanum, Myrrha, detumescence life invigorates blood circulation, loose blood, blood stasis dispelling, chase after poison, damp-clearing pain-relieving, " acrid in the mouth, hot in nature, little poison.Acrid in the mouth, warm in nature nontoxic ", enter the heart, liver, spleen channel.Enter spleen, kidney channel; Sanguis Draxonis, blood circulation promoting and blood stasis dispelling circulation of qi promoting, reducing swelling and alleviating pain, astringing to arrest bleeding, the effects such as hard masses softening and resolving, promoting tissue regeneration and ulcer healing.Modern medicine study confirms, Sanguis Draxonis has the body of improvement microcirculation, endocrine regulation, the increase body intravascular coagulation factor remarkable anastalsis is arranged, have the Yin Yang balancing dual regulation aspect the Chinese traditional treatment mass formed by blood stasis, adjusting the body metabolism, have powerful anti-inflammatory and antalgic putrefaction-removing granulation-promoting and accelerate lymphatic return and improve the effects such as body's immunity.Warm in nature, flat, sweet in the mouth, salty, nontoxic, enter lung, spleen, kidney three warps; Hirudo, salty in the mouth, hardship, property is flat, and is nontoxic.Return Liver Channel.Kind removing blood stasis divides the stasis of blood to stagnate and detumescence removing blood stasis antithrombotic; Herba Leonuri, promoting blood circulation to restore menstrual flow diuretic removing heat from blood antithrombotic, acrid in the mouth, little hardship is slightly cold.GUIXIN, liver, urinary bladder channel; Rhizoma Chuanxiong, acrid in the mouth, little perfume (or spice), warm in nature.Enter the heart, liver, gallbladder meridian.Blood circulation promoting and blood stasis dispelling antiinflammatory collateral dredging, wind-expelling pain-stopping; Herba Pyrolae (Pyrola rotundifolia ssp.chinensis), antibiotic, heart tonifying, blood vessel dilating, wind-damp dispelling invigorating the liver and kidney.Bitter in the mouth, warm in nature enters liver, kidney channel; Rhizoma Curcumae, the pain relieving of circulation of qi promoting removing blood stasis removing food stagnancy.Acrid in the mouth, hardship, warm in nature enter liver, spleen channel; Folium Et Cacumen Murrayae (pharmacy wine, slag external application), promoting flow of QI and blood, expelling wind and removing dampness, the detumescence poison ends skin and itches promoting blood circulation to remove blood stasis, wind-expelling pain-stopping.Acrid in the mouth, hardship, warm in nature enter the heart, liver, lung meridian; Herba Chenopodii Hybridi, bitter in the mouth, little suffering, property is flat, enters Liver Channel.Heat-clearing and toxic substances removing; Expelling wind and removing dampness; Promoting blood circulation and hemostasis; Eupolyphaga Seu Steleophaga, cold in nature, salty in the mouth, poisonous, enter the heart, liver, spleen channel.Have removing blood stasis, removing mass, collateral dredging, reason wound, reducing swelling and alleviating pain, stimulating milk secretion is stimulated the menstrual flow and can thrombolytic; Radix Codonopsis, invigorating the spleen and replenishing QI, the spleen invigorating lung benefiting, QI invigorating is enriched blood again and the effect of antiulcer is arranged.Nature and flavor are sweet flat, enter spleen, lung meridian; The Radix Rehmanniae (Radix Rehmanniae), nature and flavor, sweet, bitter, cold, enter the heart, liver, kidney channel.Clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting; Radix Sophorae Flavescentis. bitter in the mouth, cold in nature.Enter the heart, liver, large intestine, small intestinal, stomach warp.Heat clearing and damp drying, diuretic, anti-inflammation; Little reviving after death (Herba Gendarussae (Caulis et Folium Gendarussae vulgaris)), acrid in the mouth, hardship, property is flat.Enter liver, kidney, lung meridian.Wind-damp dispelling, dissipating blood stasis blood; Radix Rubiae, bitter in the mouth, cold in nature.Enter Liver Channel.The effect that cooling blood for hemostasis, blood stasis dispelling are arranged; Exocarpium Benincasae. sweet in the mouth, cold nature enters lung, spleen, small intestine meridian.Clearing away heat and promoting diuresis, damp eliminating chase after wind, profit skin; Radix Angelicae Pubescentis, flavor, hot, bitter, warm in nature, enter bladder, liver, kidney channel.Have that dispersing wind and cold is wet, the effect of pain relieving, blood vessel dilating; Cortex Cinnamomi, warming spleen and stomach for dispelling cold, promoting the flow of QI-blood by warming the meridian.Flavor, hot, sweet, hot in nature.Enter kidney, spleen, the heart, Liver Channel; Herba Lysimachiae (BIANDIXIANG), slightly cool in nature, sweet in the mouth perfume.Suppressing the hyperactive liver fire, clearing heat in QI system are warm, diuretic, treating stranguria, the meridian dredging; Radix Angelicae Sinensis, sweet in the mouth, suffering, warm in nature.Enter liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, inducing menstruation to relieve menalgia, loosening bowel to relieve constipation; Radix Notoginseng has and seeks hemostasis, the clots absorbing of promoting blood circulation, and antithrombotic promotes hemopoietic, and antiinflammatory protects the liver, and antitumor expands blood vessel, blood pressure lowering, resists myocardial ischemia, the effects such as anti-cerebral ischemia, arrhythmia, atherosclerosis, analgesia; Medulla Tetrapanacis, sweet in the mouth, light, cold nature enters lung, stomach warp.Clearing away heat and promoting diuresis is arranged, promote qi circulation opening feeling pulse effect.
Select medicine, select the measured pharmacopoeia of original producton location matter, medical material is cleaned dried oven dry, accurately make up a prescription according to percentage by weight, pulverize and grind, bottle for subsequent use.
2, adopt the present invention to treat varicosis clinical treatment standard as follows:
Cure: used preparation of the present invention 30 days-60 days, transference cure, check there is not recurrence after 11 months.
Effectively: used preparation of the present invention 30 days-45 days, transference cure, check after 11 months, very light symptoms appears in former scope of medication periphery.
Invalid: as to use preparation of the present invention 30 days-60 days, and had no the nonresponder.
Points for attention: this preparation is external only, please don't be oral, and anemia of pregnant woman's forbidding; There are no the skin allergy person; 3 years lower effect duration of finished product preparation air-proof condition.
The preparation method of pharmaceutical composition of the present invention is characterized in that described pharmaceutical composition comprises 24 kinds of Chinese crude drug mixed powders, medicated wine, and described powder of the present invention adopts following manufacture method to make:
Raw material: Stigma Croci 3-80 weight portion, Olibanum 3-80 weight portion, Myrrha 3-80 weight portion, Radix Rehmanniae 3-60 weight portion, Radix Sophorae Flavescentis 3-60 weight portion, Sanguis Draxonis 6-100 weight portion, Hirudo 6-100 weight portion, Herba Leonuri 3-80 weight portion, Exocarpium Benincasae 3-80 weight portion, Eupolyphaga Seu Steleophaga 3-100 weight portion, Folium Et Cacumen Murrayae 80-200 weight portion (is steep in wine, slag is used as medicine) Rhizoma Chuanxiong 3-80 weight portion, Herba Pyrolae 3-80 weight portion, Herba Chenopodii Hybridi 3-50 weight portion, Rhizoma Curcumae 3-60 weight portion, Radix Rubiae 1-30 weight portion, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 30-80 weight portion, Radix Angelicae Pubescentis 3-60 weight portion, Cortex Cinnamomi 3-60 weight portion, Herba Lysimachiae 3-100 weight portion, Medulla Tetrapanacis 3-100 weight portion, Radix Codonopsis 3-80 weight portion, Radix Angelicae Sinensis 3-30 weight portion, Radix Notoginseng 1-30 weight portion;
By above-mentioned weight proportion powder is made in various Chinese crude drug Preparation process grindings, then fully mixed bottling for subsequent use.
With Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 30-80 weight portion, soak to dry to grind with Chinese liquor and be used as medicine.
Folium Et Cacumen Murrayae 80-200 gram, 55 spend 500 milliliters of above Chinese liquor, Folium Et Cacumen Murrayae is immersed in the Chinese liquor soaked 48 hours, and then filtering bottling wine for subsequent use is medicated wine; The Folium Et Cacumen Murrayae medicinal residues dry to grind and are used as medicine.
With medicated wine powder furnishing paste of the present invention is activated dormant various compositions when giving patient's external application, directly spread on the affected part and wrap up with gauze bandage, 15 days drug effect phases.
Compared with prior art, the advantage of this patent is as follows:
1, safety: it is three minutes poison of medicine that oral medicine all has sense of discomfort, operative treatment has destroyed microcirculation and the misery of diseased region, and the present invention " a kind of treat cirsoid pure Chinese powder medicine " preparation has no side effect, therapeutic process is not simply had an injection and is not taken medicine, a drug medicine 15 days action periods is directly to focus, no pain zero injury, the special effect cure rate is high, does not recur, pure Chinese medicinal preparation, safety and environmental protection.
2, convenient: remove the patient from and go to hospital to see doctor, have an injection, perform an operation, making up the prescription boils medicine waits the complex treatment process, can oneself use with powder treatment patient of the present invention, and the treatment works well.
3, save time economical: treatment varicosis and complication mostly need several courses for the treatment of, several thousand yuan at least of expenses, ten thousand yuan at most, and relapse rate is high; Preparation a drug of the present invention (external application) drug effect can reach 15 days, and 4 costs of changing dressings two courses for the treatment of only need more than 1,000 yuan, and do not affect work and study.
4, evident in efficacy: general patient only needs medication 30 days just can fully recover to 45 days, heavier patient's vasculitis, and skin ulceration, pain, the serious skin blackout of vein projection also only need medication just can be fully recovered to 60 days in 45 days, and the special effect cure rate is high, does not recur.
5, pure Chinese medicinal preparation therapeutic modality design of the present invention has novelty, practicality, and the inner disease outer treat process is simple, domestic initiation is advanced in the world, has excited patient's resist the disease spirit and resistance against diseases.
The below is with specific embodiment description technical scheme of the present invention and technique effect.
Embodiment 1: take by weighing Stigma Croci 3 gram, Olibanum 3 grams, Myrrha 3 grams, the Radix Rehmanniae 3 grams, Radix Sophorae Flavescentis 3 grams, Sanguis Draxonis 6 grams, Hirudo 6 grams, Herba Leonuri 3 grams, Exocarpium Benincasae 3 grams, Eupolyphaga Seu Steleophaga 3 grams, Folium Et Cacumen Murrayae 80 grams (steep in wine, slag be used as medicine), Rhizoma Chuanxiong 3 grams, Herba Pyrolae 3 grams, Herba Chenopodii Hybridi 3 grams, Rhizoma Curcumae 3 grams, Radix Rubiae 1 gram, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 30 grams, Radix Angelicae Pubescentis 3 grams, Cortex Cinnamomi 3 grams, Herba Lysimachiae 3 grams, Medulla Tetrapanacis 3 grams, Radix Codonopsis 3 grams, Radix Angelicae Sinensis 3 grams and Radix Notoginseng 1 gram, these Chinese crude drug Preparation process that take by weighing are ground to form powder, then repeat to mix, bottle for subsequent use.Wherein, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 30 grams are soaked with Chinese liquor, dry rear grinding and be used as medicine; Folium Et Cacumen Murrayae is immersed in the Chinese liquor 48 hours, filters, the filtrate bottling is for subsequent use, i.e. medicated wine; The Folium Et Cacumen Murrayae medicinal residues dry to grind and are used as medicine.
Usage: described powder is modulated with the medicated wine that the immersion Folium Et Cacumen Murrayae obtains: use medicated wine according to the part by weight furnishing thick paste of 1:1.2 part this powder, the affected part is cleaned, spread on affected part thickness 3-5 millimeter, area is limited with projection or swelling scope, it is suitable around wrapping, elasticity to hold with gauze bandage with the gauze shawl first again, changed dressings in 15th one time 30 days be a course for the treatment of.
Embodiment 2
Stigma Croci 15 gram, Olibanum 15 grams, Myrrha 15 grams, the Radix Rehmanniae 15 grams, Radix Sophorae Flavescentis 15 grams, Sanguis Draxonis 25 grams, Hirudo 25 grams, Herba Leonuri 15 grams, Exocarpium Benincasae 15 grams, Eupolyphaga Seu Steleophaga 40 grams, Folium Et Cacumen Murrayae 80 grams (steep in wine, slag be used as medicine), Rhizoma Chuanxiong 15 grams, Herba Pyrolae 15 grams, Herba Chenopodii Hybridi 10 grams, Rhizoma Curcumae 15 grams, Radix Rubiae 5 grams, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 30 grams, Radix Angelicae Pubescentis 15 grams, Cortex Cinnamomi 15 grams, Herba Lysimachiae 20 grams, Medulla Tetrapanacis 20 grams, Radix Codonopsis 15 grams, Radix Angelicae Sinensis 15 grams, Radix Notoginseng 5 grams, these Chinese crude drug Preparation process that take by weighing are ground to form powder, then repeat to mix, bottle for subsequent use.
Note: Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 30 grams are soaked with 30 milliliters of 55 degree Chinese liquor, dry rear grinding and be used as medicine;
With Folium Et Cacumen Murrayae 80 gram, get 320 milliliters of 55 degree Chinese liquor, Folium Et Cacumen Murrayae is immersed in the Chinese liquor 48 hours, to filter, the filtrate bottling is for subsequent use, i.e. medicated wine; The Folium Et Cacumen Murrayae medicinal residues dry to grind and are used as medicine.
Usage: give patient's external application get it filled 160 milliliters of wine, will dormant various compositions activation with medicated wine furnishing pastes with powder 130 grams of the present invention, the affected part is cleaned, spread on affected part, thickness 3-5 millimeter, area is limited with projection or swelling scope, it is suitable around wrapping, elasticity to hold with gauze bandage with the gauze shawl first again, changed dressings in 15th one time 30 days be a course for the treatment of;
With medicated wine 40%-60% powder furnishing paste of the present invention is activated dormant various compositions when giving patient's external application, directly spread on the affected part and wrap up with gauze bandage, 15 days drug effect phases.
Embodiment 3: Stigma Croci 80 gram, Olibanum 80 grams, Myrrha 80 grams, the Radix Rehmanniae 60 grams, Radix Sophorae Flavescentis 60 grams, Sanguis Draxonis 100 grams, Hirudo 100 grams, Herba Leonuri 80 grams, Exocarpium Benincasae 80 grams, Eupolyphaga Seu Steleophaga 100 grams, Folium Et Cacumen Murrayae 200 grams (steep in wine, slag be used as medicine), Rhizoma Chuanxiong 80 grams, Herba Pyrolae 80 grams, Herba Chenopodii Hybridi 50 grams, Rhizoma Curcumae 60 grams, Radix Rubiae 30 grams, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 80 grams, Radix Angelicae Pubescentis 60 grams, Cortex Cinnamomi 60 grams, Herba Lysimachiae 100 grams, Medulla Tetrapanacis 100 grams, Radix Codonopsis 80 grams, Radix Angelicae Sinensis 30 grams, Radix Notoginseng 30 grams.
Usage is identical with embodiment 1.
Embodiment 4,
Stigma Croci 30 grams, Olibanum 30 grams, Myrrha 30 grams, the Radix Rehmanniae 25 grams, Radix Sophorae Flavescentis 25 grams, Sanguis Draxonis 35 grams, Hirudo 35 grams, Herba Leonuri 30 grams, Exocarpium Benincasae 30 grams, Eupolyphaga Seu Steleophaga 60 grams, Folium Et Cacumen Murrayae 90 grams, Rhizoma Chuanxiong 30 grams, Herba Pyrolae 30 grams, Herba Chenopodii Hybridi 20 grams, Rhizoma Curcumae 10 grams, Radix Rubiae 10 grams, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 50 grams, Radix Angelicae Pubescentis 30 grams, Cortex Cinnamomi 30 grams, Herba Lysimachiae 50 grams, Medulla Tetrapanacis 50 grams, Radix Codonopsis 30 grams, Radix Angelicae Sinensis 25 grams and Radix Notoginseng 10 grams, these Chinese crude drug Preparation process that take by weighing are ground to form powder, then repeat to mix, bottle for subsequent use.
Note: Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 50 grams are soaked with 40 milliliters of 61 degree Chinese liquor, dry rear grinding and be used as medicine;
With Folium Et Cacumen Murrayae 90 gram, get 350 milliliters of 55 degree Chinese liquor, Folium Et Cacumen Murrayae is immersed in the Chinese liquor 48 hours, to filter, the filtrate bottling is for subsequent use, i.e. medicated wine; The Folium Et Cacumen Murrayae medicinal residues dry to grind and are used as medicine.
Give patient's external application get it filled 180 milliliters of wine, will dormant various compositions activation with medicated wine furnishing pastes with powder 160 grams of the present invention, the affected part is cleaned, spread on affected part, thickness 3-5 millimeter, area is limited with projection or swelling scope, it is suitable around wrapping, elasticity to hold with gauze bandage with the gauze shawl first again, changed dressings in 15th one time 30 days be a course for the treatment of;
Embodiment 5:
Stigma Croci 23 grams, Olibanum 23 grams, Myrrha 23 grams, the Radix Rehmanniae 20 grams, Radix Sophorae Flavescentis 20 grams, Sanguis Draxonis 30 grams, Hirudo 30 grams, Herba Leonuri 23 grams, Exocarpium Benincasae 23 grams, Eupolyphaga Seu Steleophaga 50 grams, Folium Et Cacumen Murrayae 85 grams, Rhizoma Chuanxiong 23 grams, Herba Pyrolae 23 grams, Herba Chenopodii Hybridi 15 grams, Rhizoma Curcumae 23 grams, Radix Rubiae 8 grams, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 40 grams, Radix Angelicae Pubescentis 23 grams, Cortex Cinnamomi 23 grams, Herba Lysimachiae 35 grams, Medulla Tetrapanacis 35 grams, Radix Codonopsis 23 grams, Radix Angelicae Sinensis 20 grams and Radix Notoginseng 7 grams, these Chinese crude drug Preparation process that take by weighing are ground to form powder, then repeat to mix, bottle for subsequent use.
Note: Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 40 grams are soaked with 40 milliliters of 55 degree Chinese liquor, dry rear grinding and be used as medicine;
With Folium Et Cacumen Murrayae 85 gram, get 340 milliliters of 55 degree Chinese liquor, Folium Et Cacumen Murrayae is immersed in the Chinese liquor 48 hours, to filter, the filtrate bottling is for subsequent use, i.e. medicated wine; The Folium Et Cacumen Murrayae medicinal residues dry to grind and are used as medicine.
Give patient's external application get it filled 260 milliliters of wine, will dormant various compositions activation with medicated wine furnishing pastes with powder 200 grams of the present invention, the affected part is cleaned, spread on affected part, thickness 3-5 millimeter, area is limited with projection or swelling scope, it is suitable around wrapping, elasticity to hold with gauze bandage with the gauze shawl first again, changed dressings in 15th one time 30 days be a course for the treatment of;
The medicine for preparing in above-described embodiment is used for the treatment of following patient, and effect is as described below.
See table 1,218 people such as Fu (man), Lee (woman) are peripheral angiopathy varicosis through hospital diagnosis above county level, from triennial treatment clinical observation of passing through 218 people such as Fu (man), Lee (woman) in 2009 to 2011, the clinical experiment result is: always effectively be 218 people, total effective rate 100%, curing number is 216 people, cure rate 99.1%, and invalid number is 0.
Table 1
| Total number of persons | Efficiently individual quantity | Effective percentage | The healing number | Cure rate |
| 218 | 218 | 100% | 216 | 99.7% |
Model case: Fu, man, 82 years old, beautiful people from residential quarter in Nangong City, two varicose veins of the lower extremity medical histories had operative treatment history in 1975 53 years more, and the spring in 2009 was used the prescription treatment of the embodiment of the invention 5, the varicosis disease do not occur again.
Lee, man, 48 years old, the bannerman of Inner Mongol Oroqen, left lower extremity was suffered from varicosis more than 15 years, was afraid of to have a pain in the leg pain unbearably cool autumn and winter, and the sense of heaviness of walking is serious, use embodiments of the invention 2 treatments from early winter in 2009, just obtain two days later alleviating medication recovery from illness in 45 days, the varicosis disease do not occur so far.
The Wang, man, 50 years old, the Xu Zhuan village people of Jizhou City, right lower extremity varicosis medical history more than 20 years, the vein projection is serious at one's knees, and pars affecta skin is black, and the cicatrix of festering is arranged, use embodiments of the invention 3 treatments recovery from illness in 60 days, fester disappearance, Hyperplastic Scars, so far not recurrence from the winter in 2010.
Lee, the woman, 73 years old, family members people from institute of Jizhou City government, existing more than 30 years of two varicose veins of the lower extremity used embodiments of the invention 4 treatments recovery from illness in 60 days in the early spring in 2011, so far not recurrence.
By above-mentioned case as can be known, pharmaceutical composition of the present invention can effectively be treated varicosis, and have easy to use, do not recur, with low cost, the painless advantage of waiting bitterly for of patient.
Although with reference to above-mentioned each embodiment and case aforementioned embodiments of the present invention has been described, the present invention is not limited to these embodiments and can various form implements.It will be understood by those skilled in the art that in description, specify, under the condition that does not change technical spirit of the present invention or basic feature, the present invention can embodied in other realize technique effect of the present invention.Therefore, should understand these embodiments be interpreted as in every respect illustrative, should with the restriction mode not consider.Scope of the present invention should be limited by claims.
Claims (11)
1. one kind is used for the treatment of cirsoid pharmaceutical composition, comprising:
Stigma Croci 3-80 weight portion, Olibanum 3-80 weight portion, Myrrha 3-80 weight portion, Radix Rehmanniae 3-60 weight portion, Radix Sophorae Flavescentis 3-60 weight portion, Sanguis Draxonis 6-100 weight portion, Hirudo 6-100 weight portion, Herba Leonuri 3-80 weight portion, Exocarpium Benincasae 3-80 weight portion, Eupolyphaga Seu Steleophaga 3-100 weight portion, Folium Et Cacumen Murrayae 80-200 weight portion, Rhizoma Chuanxiong 3-80 weight portion, Herba Pyrolae 3-80 weight portion, Herba Chenopodii Hybridi 3-50 weight portion, Rhizoma Curcumae 3-60 weight portion, Radix Rubiae 1-30 weight portion, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 30-80 weight portion, Radix Angelicae Pubescentis 3-60 weight portion, Cortex Cinnamomi 3-60 weight portion, Herba Lysimachiae 3-100 weight portion, Medulla Tetrapanacis 3-100 weight portion, Radix Codonopsis 3-80 weight portion, the powder that Radix Angelicae Sinensis 3-30 weight portion and Radix Notoginseng 1-30 weight portion form, and
Optional pharmaceutically useful adjuvant.
2. as claimed in claim 1ly be used for the treatment of cirsoid pharmaceutical composition, comprise Stigma Croci 15-30 weight portion, Olibanum 15-30 weight portion, Myrrha 15-30 weight portion, Radix Rehmanniae 15-25 weight portion, Radix Sophorae Flavescentis 15-25 weight portion, Sanguis Draxonis 25-35 weight portion, Hirudo 25-35 weight portion, Herba Leonuri 15-30 weight portion, Exocarpium Benincasae 15-30 weight portion, Eupolyphaga Seu Steleophaga 40-60 weight portion, Folium Et Cacumen Murrayae 80-90 weight portion, Rhizoma Chuanxiong 15-30 weight portion, Herba Pyrolae 15-30 weight portion, Herba Chenopodii Hybridi 10-20 weight portion, Rhizoma Curcumae 15-30 weight portion, Radix Rubiae 5-10 weight portion, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 30-50 weight portion, Radix Angelicae Pubescentis 15-30 weight portion, Cortex Cinnamomi 15-30 weight portion, Herba Lysimachiae 20-50 weight portion, Medulla Tetrapanacis 20-50 weight portion, Radix Codonopsis 15-30 weight portion, the powder of Radix Angelicae Sinensis 15-25 weight portion and Radix Notoginseng 5-10 weight portion, and
Optional pharmaceutically acceptable auxiliaries.
3. as claimed in claim 1 or 2ly be used for the treatment of cirsoid pharmaceutical composition, the medicinal residues of wherein said Folium Et Cacumen Murrayae for obtaining after the above Chinese liquor of bubble 55 degree.
4. as claimed in claim 3ly be used for the treatment of cirsoid pharmaceutical composition, wherein further comprise the medicated wine that obtains by soaking Folium Et Cacumen Murrayae.
5. as claimed in claim 4ly be used for the treatment of cirsoid pharmaceutical composition, the weight ratio of wherein said medicated wine and described powder in the scope of 1:1 to 1:6, preferred 1:1 to 1:4, more preferably 1:1.2.
6. one kind is used for the treatment of cirsoid pharmaceutical composition, is prepared as raw material by the compositions that comprises the following traditional Chinese medicines material and pharmaceutically useful adjuvant:
Stigma Croci 3-80 weight portion, Olibanum 3-80 weight portion, Myrrha 3-80 weight portion, the Radix Rehmanniae-60 weight portion, Radix Sophorae Flavescentis 3-60 weight portion, Sanguis Draxonis 6-100 weight portion, Hirudo 6-100 weight portion, Herba Leonuri 3-80 weight portion, Exocarpium Benincasae 3-80 weight portion, Eupolyphaga Seu Steleophaga 3-100 weight portion, Folium Et Cacumen Murrayae 80-200 weight portion, Rhizoma Chuanxiong 3-80 weight portion, Herba Pyrolae 3-80 weight portion, Herba Chenopodii Hybridi 3-50 weight portion, Rhizoma Curcumae 3-60 weight portion, Radix Rubiae 1-30 weight portion, the little 30-80 weight portion of reviving after death, Radix Angelicae Pubescentis 3-60 weight portion, Cortex Cinnamomi 3-60 weight portion, Herba Lysimachiae 3-100 weight portion, Medulla Tetrapanacis 3-100 weight portion, Radix Codonopsis 3-80 weight portion, Radix Angelicae Sinensis 3-30 weight portion, Radix Notoginseng 1-30 weight portion.
7. as claimed in claim 6ly be used for the treatment of cirsoid pharmaceutical composition, further comprise the medicated wine that obtains by soaking Folium Et Cacumen Murrayae, the weight ratio of described medicated wine and described powder in the scope of 1:1 to 1:6, preferably 1:1 to 1:4, more preferably 1:1.2.
One kind for the preparation of the treatment cirsoid pharmaceutical composition method, comprising:
Adopt Stigma Croci 3-80 weight portion, Olibanum 3-80 weight portion, Myrrha 3-80 weight portion, Radix Rehmanniae 3-60 weight portion, Radix Sophorae Flavescentis 3-60 weight portion, Sanguis Draxonis 6-100 weight portion, Hirudo 6-100 weight portion, Herba Leonuri 3-80 weight portion, Exocarpium Benincasae 3-80 weight portion, Eupolyphaga Seu Steleophaga 3-100 weight portion, Folium Et Cacumen Murrayae 80-200 weight portion, Rhizoma Chuanxiong 3-80 weight portion, Herba Pyrolae 3-80 weight portion, Herba Chenopodii Hybridi 3-50 weight portion, Rhizoma Curcumae 3-60 weight portion, Radix Rubiae 1-30 weight portion, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 30-80 weight portion, Radix Angelicae Pubescentis 3-60 weight portion, Cortex Cinnamomi 3-60 weight portion, Herba Lysimachiae 3-100 weight portion, Medulla Tetrapanacis 3-100 weight portion, Radix Codonopsis 3-80 weight portion, Radix Angelicae Sinensis 3-30 weight portion and Radix Notoginseng 1-30 weight portion are as raw material
By above-mentioned weight proportion powder is made in various Chinese crude drug Preparation process grindings, then fully mixed;
Wherein said Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) soaks to dry with Chinese liquor and grinds afterwards the rear described pharmaceutical composition that adds again;
Wherein said Folium Et Cacumen Murrayae is dried the medicinal residues that obtain with after the soaking in Chinese liquor, adds described pharmaceutical composition after grinding again.
9. method as claimed in claim 8, the weight ratio of wherein said Folium Et Cacumen Murrayae and Chinese liquor be 1: 1 to 1:6, preferred 1:4, described Chinese liquor are the above Chinese liquor of 55 degree.
10. method as claimed in claim 8 or 9 further comprises the step of the medicated wine modulation that described powder is obtained with the immersion Folium Et Cacumen Murrayae.
11. the pharmaceutical composition such as each described method preparation among the claim 8-10.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210423982.6A CN102895600B (en) | 2012-10-30 | 2012-10-30 | Pharmaceutical composition for treatment of varicosity and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142884A (en) * | 2013-03-11 | 2013-06-12 | 高怀玉 | Traditional Chinese medicine for treating varicosis |
| CN104274744A (en) * | 2014-10-27 | 2015-01-14 | 哈尔滨金玉科技开发有限公司 | Pharmaceutical composition for treating varicosity and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1444952A (en) * | 2002-03-16 | 2003-10-01 | 王守卷 | Wiping and spreading tincture with wide effect and its preparing method |
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| CN1444952A (en) * | 2002-03-16 | 2003-10-01 | 王守卷 | Wiping and spreading tincture with wide effect and its preparing method |
Non-Patent Citations (1)
| Title |
|---|
| 王翠莲等: "血栓性静脉炎的中医药治疗概况", 《内蒙古中医药》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142884A (en) * | 2013-03-11 | 2013-06-12 | 高怀玉 | Traditional Chinese medicine for treating varicosis |
| CN104274744A (en) * | 2014-10-27 | 2015-01-14 | 哈尔滨金玉科技开发有限公司 | Pharmaceutical composition for treating varicosity and preparation method thereof |
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