CN102850233A - Method for preparing tyrosine nitrate - Google Patents
Method for preparing tyrosine nitrate Download PDFInfo
- Publication number
- CN102850233A CN102850233A CN 201110174952 CN201110174952A CN102850233A CN 102850233 A CN102850233 A CN 102850233A CN 201110174952 CN201110174952 CN 201110174952 CN 201110174952 A CN201110174952 A CN 201110174952A CN 102850233 A CN102850233 A CN 102850233A
- Authority
- CN
- China
- Prior art keywords
- tyrosine
- nitrate
- preparation
- water
- nitric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses a method for preparing tyrosine nitrate. The preparation method includes: dissolving tyrosine in water, uniformly stirring, dripping nitric acid, controlling temperature at 20-60 DEG C., completing dripping in 30 min, keeping the temperature, stirring for 20 min to until the solution is gradually clear, vacuum dewatering at 50-65 DEG C., cooling the dewatered material solution less than or equal to 10 DEG C., separating out solid, filtering, and drying to obtain the tyrosine nitrate product with few impurities, good quality and high purity above 99% without recrystallization. The invention adopts mother liquor for cycling utilization, improves yield, saves valuable water source, and simultaneously has no by-product and almost no three-waste generation in production; and the preparation method of the invention has reasonable and simple process, and environmental protection, and is suitable for industrial production.
Description
Technical field
The present invention relates to a kind of preparation method of amino acid salts, specifically a kind of preparation method of tyrosine nitrate.
Background technology
Amino acid is the base substance that consists of the Animal nutrition desired protein.General people self generate or can obtain to satisfy by food each seed amino acid of somagenic need.But in the situation that special as human infantile period, in the situation that sick, injured or large amount of exercise is taken exercise, for growth needs, recover the balance of various metabolism in the body, strengthening immunity and sportsmen regain one's strength as early as possible, increase muscle strength, just need extra each seed amino acid that replenishes.
The tyrosine chemical name is: 2-amino-3-is to hydroxyphenylpropionic acid.And the common heat of carbohydrate can produce the reaction between aminocarboxyl, and produces a kind of special spices.Non-essential amino acid.
Tyrosine is the catalytic substrate of tyrosine oxidase list phenolase function, is the final main raw material that forms excellent melanocyte and pheomelanin.Patients with vitiligo is eaten the food that contains tyrosine can promote melanic formation, alleviates the vitiligo symptom.Other aspect tyrosine can be used as hyperthyroidism aspect medical; Foodstuff additive.It is the main raw material of the medicines such as synthetic peptide hormone, microbiotic, L-3,4 dihydroxyphenylalanine.Also as drink additive and the artificial insect feedstuff of preparation.
Because amino acid salts analogy amino acid easily is dissolved in the water, it is transformed into amino acid at last through effects such as oxydase in vivo, compare and take directly that amino acid is easier to be absorbed by health, take so amino acid is all made amidates usually, generally make the amino acid salts hydrochlorate more.Recently U.S. parties concerned research discovery, amino acid whose nitrate more is conducive to Amino Acid Absorption, therefore tyrosine is made into tyrosine nitrate and takes, and will more easily change into tyrosine, is absorbed by health.Dosage can be less when it used, and oral absorption efficient can be higher.
Summary of the invention
The present invention provides a kind of preparation method of tyrosine nitrate for obtaining the systemic tyrosine of body more preferably.
The present invention is that the technical scheme that the technical problem that exists in the above-mentioned technology of solution is taked is:
The preparation method of a kind of tyrosine nitrate of the present invention is as follows: tyrosine is dissolved in the water, rear dropping nitric acid stirs, temperature is controlled at 20 ℃～60 ℃, dropwise in 30 minutes, continued insulated and stirred 20 minutes, solution is clarified gradually, vaccum dewatering under 50 ℃～65 ℃ conditions subsequently, feed liquid after dewatering is cooled to≤10 ℃, separate out solid, filter, after the drying tyrosine nitrate finished product.The liquid of separating out behind the solid recycles aborning as mother liquor.
The mol ratio of described tyrosine and nitric acid is 1: 1～1.1.
The ratio of described tyrosine and water is 1g: 2ml.
Advantage and positively effect that the present invention has are: the raw material that the present invention adopts is the tyrosine of food grade and the nitric acid of chemical reagent-grade, so the tyrosine nitrate product impurity of producing is few, quality is good, just reach more than 99% without recrystallization purity, both guaranteed quality, save again operation and production time, improved production efficiency.The present invention utilizes Recycling Mother Solution to use, and has improved yield, has reduced cost.Saved valuable water resources.Simultaneously the present invention is no coupling product aborning, produces hardly the three wastes.Preparation method's technique of the present invention is reasonable, simple, and environmental protection is fit to industrialized production.
Embodiment
Solubleness among the present invention in the tyrosine water is less, need add a certain amount of water during reaction, and water is deionized water, to guarantee the quality of product.Below just no longer repeating water in the narration is deionized water.
The mol ratio of tyrosine and nitric acid should be 1: 1 among the present invention, but for tyrosine is reacted completely, nitric acid dosage should be more bigger than tyrosine.Scope is between 1～1.1 mole.
Temperature of reaction of the present invention should be controlled at below 60 ℃, and the temperature of vaccum dewatering should be controlled at below 65 ℃, otherwise can exert an adverse impact to product.
Liquid after the present invention will filter carries out recycle as mother liquor.Owing to filtering out the tyrosine nitrate that does not have in addition crystallization in the liquid after the crystallization, when it was used for next step production, the crystallization that produces can both be separated out more than 95%, has greatly improved actual recovery.
For further understanding summary of the invention of the present invention, Characteristic, hereby exemplify following examples:
Embodiment 1
Take by weighing tyrosine 18.2g(0.1 mole) put into reaction flask, add 36.4ml water, stir, while stirring the nitric acid 10g(0.1 mole that drips 65% concentration), 55 ℃ of control temperature dropwised in 20 minutes, continued insulated and stirred 20 minutes, solution is clarified gradually.Be warming up to subsequently 60 ℃, vaccum dewatering, the feed liquid after dewatering is cooled to 5 ℃, separates out solid, gets tyrosine nitrate finished product after filtration, the drying.Liquid after the filtration recycles aborning as mother liquor.
Embodiment 2
Take by weighing tyrosine 18.2g(0.1 mole) put into reaction flask, add mother liquor 36.4ml, stir, while stirring the nitric acid 10g(0.1 mole that drips 65% concentration), the control temperature dropwised at 40 ℃ in 10 minutes, continued insulated and stirred 20 minutes, solution is clarified gradually.Be warming up to subsequently 55 ℃, vaccum dewatering, the feed liquid after dewatering is cooled to 10 ℃, separates out solid, gets tyrosine nitrate finished product after filtration, the drying.Liquid after the filtration recycles aborning as mother liquor.
Embodiment 3
Take by weighing tyrosine 18.2g(0.1 mole) put into reaction flask, add the 36.4ml mother liquor, stir, while stirring the nitric acid 10g(0.1 mole that drips 65% concentration), 25 ℃ of control temperature dropwised in 30 minutes, continued insulated and stirred 20 minutes, solution is clarified gradually.Be warming up to subsequently 50 ℃, vaccum dewatering, the feed liquid after dewatering is cooled to 0 ℃, separates out solid, gets tyrosine nitrate finished product after filtration, the drying.Liquid after the filtration recycles aborning as mother liquor.
Claims (3)
1. the preparation method of a tyrosine nitrate, it is characterized in that the preparation method is as follows: tyrosine is dissolved in the water, the rear dropping nitric acid that stirs, temperature is controlled at 20 ℃～60 ℃, dropwise in 30 minutes, continued insulated and stirred 20 minutes, solution is clarified gradually, subsequently vaccum dewatering under 50 ℃～65 ℃ conditions, feed liquid after dewatering is cooled to≤and 10 ℃, separate out solid, filter, after the drying tyrosine nitrate finished product, the liquid of separating out behind the solid recycles aborning as mother liquor.
2. the preparation method of tyrosine nitrate according to claim 1, the mol ratio that it is characterized in that tyrosine and nitric acid is 1: 1～1.1.
3. the preparation method of tyrosine nitrate according to claim 1, the ratio that it is characterized in that tyrosine and water is 1g: 2ml.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110174952 CN102850233A (en) | 2011-06-27 | 2011-06-27 | Method for preparing tyrosine nitrate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110174952 CN102850233A (en) | 2011-06-27 | 2011-06-27 | Method for preparing tyrosine nitrate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102850233A true CN102850233A (en) | 2013-01-02 |
Family
ID=47397271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110174952 Pending CN102850233A (en) | 2011-06-27 | 2011-06-27 | Method for preparing tyrosine nitrate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102850233A (en) |
-
2011
- 2011-06-27 CN CN 201110174952 patent/CN102850233A/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101508658A (en) | Method of preparing taurine | |
| CN101508657A (en) | Synthesis of taurine | |
| CN101508659A (en) | Method for preparing taurine | |
| CN105601542A (en) | Method for crystallizing N-carbamylglutamic acid with mixed acid | |
| CN108191688A (en) | A kind of method synthesized and crystallize D-VB5 calcium | |
| CN107337618A (en) | It is a kind of while improve Metformin hydrochloride purity and the production method of yield | |
| CN104016888A (en) | Method for preparing 2-taurine | |
| CN102408347A (en) | Method for preparing monopotassium L-aspartate dihydrate by separation process | |
| CN103167872B (en) | For the production of the method for VBT tartrate | |
| CN102351790B (en) | Method for synthesizing 7-bromo-6-chloro-4-quinazolinone | |
| CN107778202A (en) | A kind of preparation method of Metformin hydrochloride | |
| CN107445869A (en) | A kind of synthetic method of Metformin hydrochloride | |
| CN102838512A (en) | Preparation method of creatine nitrate | |
| CN101844992B (en) | Preparation process of Beta lactamine | |
| CN102718833A (en) | Preparation method of glycyl-tyrosine | |
| CN102850233A (en) | Method for preparing tyrosine nitrate | |
| CN102850232A (en) | Preparation method of L-serine nitrate | |
| CN102850241A (en) | Preparation method of guanidine acetic acid nitrate | |
| CN101844991B (en) | Preparation method of L-leucine nitrate | |
| CN101811991A (en) | Method for preparing L-arginine nitrate | |
| CN102838502A (en) | Preparation method of L-phenylalanine nitrate | |
| CN102838499A (en) | Preparation method of betaine nitrate | |
| CN102850242A (en) | Preparation method of guanidine propionic acid nitrate | |
| CN106365980A (en) | Method for preparing anhydrous sodium acetate | |
| CN102850250A (en) | Preparation method of proline nitrate |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130102 |