CN102846700B - Traditional Chinese medicine composition used for preventing and treating mixed infection of poultry coccidiosis and necrotic enteritis - Google Patents
Traditional Chinese medicine composition used for preventing and treating mixed infection of poultry coccidiosis and necrotic enteritis Download PDFInfo
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Abstract
The invention relates to traditional Chinese medicine composition used for preventing and treating mixed infection of poultry coccidiosis and necrotic enteritis. The traditional Chinese medicine composition takes common cephalanoplos herb used for cooling blood and hemostasis, removing stasis and dispersing swellings as monarch drug, and takes sweet wormwood herb used for clearing deficiency-heat, cooling blood and removing steam as minister drug. Moreover, the traditional Chinese medicine composition is additionally provided with astragalus used for tonifying qi, strengthening exterior, eliminating sores and promoting granulation, and white atractylodes rhizome used for invigorating spleen, supplementing qi, eliminating dampness, and alleviating water retention as the assistant drug and liquorice used for tonifying spleen and qi and clearing away heat and toxic materials is used for coordinating the drugs. The traditional Chinese medicine composition has the functions of cooling blood, removing stasis, clearing heat and toxic materials, and consolidating basis of the human body, and can meets the prevention and cure requirements of different paroxysm stages of the mixed infection of poultry coccidiosis and necrotic enteritis. The clinical application of a large amount of poultry diseases proves that the traditional Chinese medicine composition has the advantages of precise effects, no toxic and side effects, no drug residue and the like.
Description
A?composition?of?Chinese?traditional?medicine?preventing?polyinfection?of?cidiosis?and?Necrotic?Enteritis?of?poultry
Technical field
The invention belongs to veterinary drug preparation production and application, relate to a kind of Chinese prescription, especially relate to a kind of Chinese medicine composition of preventing and treating coccidiosis of domestic fowls and necrotic enteritis mixed infection.
Background technology
Coccidiosis is the most serious and the most normal the protozoacide of current harm poultry husbandry.Find in the clinical practice that the case that most coccidiosis infect often forms mixed infection with necrotic enteritis.On pathogeny, when coccidium infection occurs, lose barrier action owing to the integrity of intestinal mucosa is damaged, for door has been opened wide in the invasion of pathogenic entero becteria such as bacillus perfringens, clostridieum welchii, and be the diffusion of the breeding of pathogenic bacterium and the toxin condition of providing convenience.Thereby the infection of coccidiosis is the main infection inducement of necrotic enteritis often.On the other hand, when necrosing enteritis, the toxin that pathogenic bacterium discharge causes the damage of intestinal mucosa, also can cause poultry that the susceptibility of coccidiosis is strengthened.In addition, the diarrhoea that enteritis causes has strengthened pouity dwelling place bedding and padding humidity, has also further promoted the hatching of coccidium infection gamogenetic egg capsule, has increased the chance of coccidium infection.Thereby veterinary clinic often forms circulation secondary and the concurrent infection of coccidiosis and necrotic enteritis, brings the tremendous economic loss.
Chinese veterinarian's theory thinks, the diarrhoea that is caused by coccidiosis, necrotic enteritis, dysentery etc. all belong to the categories such as hemorrhoidal hamorrhage dysentery, epidemic febrile disease blood-retention.The poultry internal organs are tender and lovely, and hedge is loose, and yin and yang 2 Qi is all more childish and tender, and it is weak to defend outer function, poor to the resistance of exopathogen.Especially heat-damp in summer in season when, damp and hot malicious heresy is pented up the intestinal internal organs, so that small intestinal dereliction of duty, functional activity of QI being not smooth is logically fallen unfavorablely, clear QI being mixed up with turbid QI, injury of blood collaterals by heat, the absurd row of blood gesture, blood internal organs overflow in intestinal and send out and be primary disease.The Therapeutic Principle that this is sick should fully take into account the tender characteristics of poultry internal organs, in removing heat from blood removing blood stasis, heat-clearing and toxic substances removing, notices that Bao Jin deposits the moon, vital base and primordial QI consolidating.
To the control of coccidiosis, necrotic enteritis, although reported that some are antibiotic, the therapeutic scheme of anticoccidial, the report of some Chinese prescriptions is also arranged, but still there are the following problems at present:
1. the Chinese prescription of reporting mainly biases toward the principle of parasite killing, anthelmintic on the principles of formulating prescriptions, do not consider the concertedness of coccidiosis and necrotic enteritis morbidity, thereby is difficult to effectively control the bounce-back of disease after the treatment.2. because coccidiosis and necrotic enteritis are highly similar on clinical symptoms, and very easily occur the circulation secondary between the two, thereby single coccidiostat or antibacterials are difficult to obtain satisfactory effect.3. anticoccidial commonly used, antibacterial Western medicine preparation are often cut owing to chemical sproof generation causes uncertain therapeutic efficacy.
Summary of the invention
In view of the deficiencies in the prior art, the object of the invention is to provides a kind of Chinese medicine composition of preventing and treating coccidiosis of domestic fowls and necrotic enteritis mixed infection by prescription again after the Chinese medicine pharmacology is studied.Said composition is as a kind of pure Chinese medicinal preparation, to effective control coccidiosis of domestic fowls and necrotic enteritis mixed infection, and reduce antibacterials in the poultry farming process use, to reduce drug residue etc. significant.
In order to solve the existing problem of background technology, the present invention is by the following technical solutions:
A kind of Chinese medicine composition for control coccidiosis of domestic fowls and necrotic enteritis mixed infection is formed by the active fraction preparation of following weight portion: Herba Cirsii 30-60 part, Herba Artemisiae Annuae 30-50 part, Radix Astragali 15-30 part, Rhizoma Atractylodis Macrocephalae 15-30 part, Radix Glycyrrhizae 10-25 part.
Preferably, described Chinese medicine composition for control coccidiosis of domestic fowls and necrotic enteritis mixed infection is formed by the active fraction preparation of following weight portion: Herba Cirsii 40-50 part, Herba Artemisiae Annuae 30-45 part, Radix Astragali 15-25 part, Rhizoma Atractylodis Macrocephalae 15-25 part, Radix Glycyrrhizae 10-20 part.
Further preferably, described Chinese medicine composition for control coccidiosis of domestic fowls and necrotic enteritis mixed infection is formed by the active fraction preparation of following weight portion: Herba Cirsii 40-50 part, Herba Artemisiae Annuae 30-40 part, Radix Astragali 20-25 part, Rhizoma Atractylodis Macrocephalae 20-25 part, Radix Glycyrrhizae 15-20 part.
The present invention presses the Chinese powder medicine of the general production technology manufacture of veterinary drug powder, feeds or boiled water punching is stewing, the poultry of feeding after decocting by spice, in case manage a household avian coccidiosis and necrotic enteritis mixed infection.
The present invention becomes oral liquid by the general production technology manufacture of veterinary drug oral liquid, also can become Chinese medicine granules according to veterinary drug granule technological process of production manufacture.
Therefore, described Chinese medicine composition for control coccidiosis of domestic fowls and necrotic enteritis mixed infection, it is powder, granule or oral liquid.Described poultry is laying hen, broiler, turkey, goose and Carnis Coturnicis japonicae etc.
According to the Chinese medicine Historical Data Data About, above-mentioned 5 flavor Chinese crude drugs have following pharmacologically active and function cures mainly:
Herba Cirsii: be the aerial parts of feverfew field thistle Cephalanoplos segetum (Bunge) Kitam..Property is sweet, bitter, cold.GUIXIN, Liver Channel.The function cooling blood for hemostasis, removing blood stasis to reduce swelling.Be used for epistaxis, spit blood, hematuria, the disease such as have blood in stool.
Herba Artemisiae Annuae: feverfew Herba Artemisiae annuae Artemisia annua L. dry aerial parts.The property bitter, suffering, cold.Return liver, gallbladder meridian, three warmers, kidney channel.The clear thoroughly deficiency-heat of function, removing heat from blood is except steaming preventing the attack (or recurrence) of malaria.
The Radix Astragali: be the root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.).Property is sweet, tepor.Return lung, spleen, liver, kidney channel.Has the effect that benefiting QI for strengthening the superficies, arresting sweating take off, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema admittedly.It is weak to be used for the treatment of the deficiency of vital energy, sinking of QI of middle-JIAO, and the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and bursts for a long time and the disease such as does not hold back.
The Rhizoma Atractylodis Macrocephalae: the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..The property bitter, sweet, temperature.Return spleen, stomach warp.Effect invigorating the spleen and benefiting QI, dampness diuretic.Be used for insufficiency of the spleen lack of appetite, the abdominal distention disease such as have loose bowels.
Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Select the Fisch. for dicotyledon pulse family Leguminosae Radix Glycyrrhizae Glycyrrhiza uralensis, Glycyrrhiza inflata Bat. G. inflata Bat., or the root and rhizome of Glycyrrhiza glabra L. G. glabra L..
Compared with prior art, the Chinese medicine composition that is used for control coccidiosis of domestic fowls and necrotic enteritis mixed infection that the present invention relates to has following advantage and marked improvement: 1. prescription of the present invention belongs to hemorrhoidal hamorrhage dysentery, epidemic febrile disease blood-retention disease according to coccidiosis of domestic fowls and necrotic enteritis mixed infection, and the tender and lovely dialectical relationship of poultry internal organs, take removing heat from blood removing blood stasis, heat-clearing and toxic substances removing as the basic rule for the treatment of, take into account vital base and primordial QI consolidating, thereby realize the target for the treatment of both the principal and secondary aspects of a disease.2. Chinese medicine composition disclosed by the invention is prepared from by 5 flavor Chinese crude drugs, and raw material is simple and easy to, and cost is lower, economic and practical.3. this prescription is take the Herba Cirsii of cooling blood for hemostasis, removing blood stasis to reduce swelling as monarch, remove the Herba Artemisiae Annuae of steaming as minister take clear thoroughly deficiency-heat, removing heat from blood, assistant is with the Rhizoma Atractylodis Macrocephalae of benefiting QI for strengthening the superficies, the Radix Astragali that holds in the palm the skin ulcer granulation promoting and invigorating the spleen and benefiting QI, dampness diuretic, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription with invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, gather altogether the effect of removing heat from blood removing blood stasis, heat-clearing and toxic substances removing, vital base and primordial QI consolidating, be adapted to coccidiosis of domestic fowls and necrotic enteritis separately or the control needs in mixed infection different onset stage.4. the present invention is pure Chinese medicinal preparation, and to the effectively antibiotic use of minimizing in the poultry farming process, and it is significant to reduce drug residue.
Summary of the invention
Below be specific embodiments of the invention, technical scheme of the present invention is done further the description, but protection scope of the present invention is not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
Embodiment one: the preparation of Chinese powder medicine
Chinese medicine composition is by 30 parts of Herba Cirsiis, 50 parts of Herba Artemisiae Annuaes, 15 parts of the Radixs Astragali, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of compositions of Radix Glycyrrhizae.The described Chinese medicine of respectively distinguishing the flavor of is the prepared slices of Chinese crude drugs that meet " Chinese veterinary pharmacopoeia " related standards, and each ratio is weight portion.With each Chinese medicine co-grinding, cross 60 order spin vibration sieves, thicker Chinese medicinal granule is pulverized again, and always mixed Chinese medicine fine powder is packed as the 1kg/ bag, and get final product.Chinese powder medicine by this method production, the mode of generally feeding by spice is used for the control of the coccidiosis of domestic fowls such as broiler, laying hen and necrotic enteritis, when being used for the treatment of, this powder can also be boiled in a covered pot over a slow fire 30 minutes with the boiled water punching of 8-10 times of weight portion, supernatant drinking-water, the medicinal residues spice is for the total effective rate of coccidiosis and necrotic enteritis mixed infection more than 97%.
Embodiment two: the preparation of Chinese medicine oral liquid
Chinese medicine composition is by 60 parts of Herba Cirsiis, 30 parts of Herba Artemisiae Annuaes, 30 parts of the Radixs Astragali, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 25 parts of compositions of Radix Glycyrrhizae.The described Chinese medicine of respectively distinguishing the flavor of is the prepared slices of Chinese crude drugs that meet " Chinese veterinary pharmacopoeia " related standards, and each ratio is weight portion.Each Chinese medicine is added 10 times of amounts (weight ratio) purified water soaked 5 hours, be heated to boiling, be incubated 1 hour, wait the cold supernatant that leaches, add again 8 times of amounts (weight ratio) purified water and be heated to boiling, be incubated 1 hour, filter, merge filtrate twice, heating is concentrated into crude drug than being 0.5kg/L, add ethanol to the 75%(volume ratio), precipitate 12 hours, supernatant heating recovery ethanol, and medicinal liquid is concentrated into crude drug than for 1kg/L, it is anticorrosion to add 0.3% sodium benzoate, fill, gland and get final product.By the Chinese medicine oral liquid that this method is produced, can directly use by drinking-water, because Chinese medicine has rapidly characteristics of onset through extraction process.
Embodiment three: the preparation of Chinese medicine granules
Chinese medicine composition is by 50 parts of Herba Cirsiis, 40 parts of Herba Artemisiae Annuaes, 25 parts of the Radixs Astragali, 25 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of compositions of Radix Glycyrrhizae.The described Chinese medicine of respectively distinguishing the flavor of is the prepared slices of Chinese crude drugs that meet " Chinese veterinary pharmacopoeia " related standards, and each ratio is weight portion.Each Chinese medicine is added 10 times of amounts (weight ratio) purified water to be soaked 2 hours, be heated to boiling, be incubated 1 hour, wait the cold supernatant that leaches, add again 8 times of amounts (weight ratio) purified water and be heated to boiling, be incubated 1 hour, filter, merge filtrate twice, heating is concentrated into crude drug than for 0.5kg/L, adds ethanol to the 75%(volume ratio), precipitate 12 hours, supernatant heating recovery ethanol, and medicinal liquid is concentrated into crude drug than for 5kg/L, add an amount of sucrose or glucose, granulate, the granule that crude drug content is 1kg/kg is made in oven dry, packing and get final product.The characteristics such as by the Chinese medicine granules of this method preparation, the aquation of can heating during application is opened, and feeds by drinking-water, and it is rapid to have an onset, and accumulating is convenient.
Embodiment four: the clinical practice example of traditional Chinese medicine composition for treating chicken coccidiosis of the present invention and necrotic enteritis
In order to verify that further Chinese medicine composition of the present invention is to the clinical efficacy of coccidiosis of domestic fowls and necrotic enteritis mixed infection, select the broiler chicken of natural infection morbidity, provide anticoccidial drug and antimicrobial drug for oneself as the positive control medicine with plant, carried out contrast test.
1. materials and methods
1.1 test material
Chinese powder medicine is pressed embodiment 1 described method preparation; Chinese medicine oral liquid is pressed embodiment 2 described method preparations; Chinese medicine granules is pressed embodiment 3 described method preparations.
The positive control medicine: anticoccidial drug toltrazuril solution, antimicrobial drug lincomycin hydrochloride soluble powder by plant available from western Shandong veterinary drug limited company.
Laboratory animal: clinical symptoms is arranged, 20 Day-old Broiler Chickens of coccidiosis and necrotic enteritis are arranged through the natural infection of the excrement certificate of inspection.
1.2 test method
White plumage broiler 24634 plumages of Luo Si 308 commercial generations of 23 age in days natural infections morbidity are diagnosed as coccidiosis, necrotic enteritis through cuing open inspection, are divided at random 4 groups.
1 hen house of positive controls, totally 2943 plumages, toltrazuril solution, the administration of lincomycin hydrochloride soluble powder by specification drinking-water, every day 1 time, being used in conjunction 5 days is a course for the treatment of.
1 hen house 3500 plumage of Chinese powder medicine group are pressed the 1.5g/kg body weight and are calculated dosage.Chinese medicine is directly admixed feedstuff and is fed, and every day 1 time, being used in conjunction 5 days is a course for the treatment of.
Each 1 hen house of Chinese medicine oral liquid group and Chinese medicine granules group, amount of livestock on hand is respectively 3096 plumages and 2987 plumages, with the crude drug cubage, presses the 1.5g/kg body weight and calculates dosage.Every day 1 time, being used in conjunction 5 days is a course for the treatment of.
2. result of the test
2.1 morbidity chicken public sentiment condition and diagnosis
Therapeutic test is the white plumage broiler of 23 age in days Luo Si, 308 commercial generations that Shandong Jimo Animal Raising Zone is raised with animal.This Animal Raising Zone has 7 hen houses.Raising to 14 age in days carries out a little less than the fabricius bursa after the malicious Seedling immunity, and wherein material reducing, lack of appetite material appears increasing slowly or in 4 hen houses successively, and lassitude is arranged thin excrement, and the incidence of mucus, the blood streak (piece) is arranged in the feces subsequently.Adopt sulfa drugs control course for the treatment of (7 days), fail effectively to improve advancing of disease.Death is increased to about 2% suddenly during to 23 age in days.After the chicken that dies of illness was cutd open inspection and as seen cuts the abdominal cavity open, the remarkable enlargement of pathological changes intestinal segment had gas, has the canescence circular spot that differs in size to be mixed with mutually with the purple petechia; Cut the local small intestinal of pathological changes, see that intestinal wall thickens, coarse, ulcer and necrosis, and form the gangrenosum acne pseudomembrane, easily peel off; A large amount of rufous blood sample things are arranged in the enteric cavity or contain the fraction of blood clot.The saturated common salt solution floating method a large amount of coccidian oocysts in the chicken group feces of can finding to fall ill; Aseptic scraping pathological changes intestinal mucosa position smear, the Gram-positive bacillus of the blunt round tubbiness in the visible two ends of microscopy behind the Gram’s staining, independent or one-tenth way double-line.According to chicken group's incidence and cut open the inspection symptom, in conjunction with laboratory diagnosis, meet the performance of chicken coccidiosis, necrotic enteritis mixed infection.
2.2 contrast test
This type of disease is also multiple habitually in the past in this plant, adopts traditionally antibiotics and chemosynthesis class comprehensive drug treatment, can control to a certain extent dead continuing to increase, but easily produce drug resistance and drug residue, and the later stage death rate is high.Through consulting with the technical staff of plant, the hen house of falling ill is carried out the curative effect contrast test.Wherein, 1 hen house adopts toltrazuril solution and lincomycin hydrochloride soluble powder, as positive controls; Because toltrazuril solution adds water with lincomycin hydrochloride soluble powder and mixes rear appearance precipitation, separates out, the Consult drug operation instruction, matched group taked to use first toltrazuril solution 2 days, re-used 3 days therapeutic scheme of lincomycin hydrochloride.Other 3 hen houses are selected to use respectively Chinese powder medicine, Chinese medicine granules and Chinese medicine oral liquid as experimental group at random.The mortality rate that matched group and each experimental group were all added up in the course for the treatment of (5 days) is as shown in table 1.
Table 1 herbal mixture and antibacterial therapy result (5 days statistical datas)
| Group | Sample number (plumage) * | Death toll (plumage) | Mortality rate (%) |
| Positive controls | 2943 | 215 | 7.3% |
| Chinese powder medicine | 3500 | 70 | 2.0% |
| Chinese medicine oral liquid | 3096 | 40 | 1.3% |
| Chinese medicine granules | 2987 | 45 | 1.5% |
* each experimental group sample number system is advanced young number by each hen house, deducts the dead number of washing in a pan of accumulative total and calculates and get
After positive controls adopted the anticoccidial treatment, mortality rate descended to some extent, and up to medication the 5th day, hen house is ill chicken death phenomenon still.Chinese powder medicine experimental group, medication death substantially occurs after the 4th day again, and Chinese medicine oral liquid, the medication of Chinese medicine granules experimental group substantially occur dead after the 3rd day.Show that Chinese drug-treated group of the present invention can effectively be controlled advancing of disease, and Chinese medicine is after extracting, onset is very fast.
After answer plant's requirement, positive controls also adopts Chinese powder medicine treatment, is used in conjunction 3 days and has effectively controlled afterwards death.When after this raising to 35 age in days, other hen houses of plant prevent with the Chinese powder medicine spice, and dosage reduces by half, and is used in conjunction 5 days, delivers for sale to 45 days similar conditions not occur, has further verified the effect of this Chinese medicine.
Claims (5)
1. Chinese medicine composition that is used for control coccidiosis of domestic fowls and necrotic enteritis mixed infection, it is characterized in that: this Chinese medicine composition is formed by the active fraction preparation of following weight portion: Herba Cirsii 30-60 part, Herba Artemisiae Annuae 30-50 part, Radix Astragali 15-30 part, Rhizoma Atractylodis Macrocephalae 15-30 part, Radix Glycyrrhizae 10-25 part.
2. the Chinese medicine composition for control coccidiosis of domestic fowls and necrotic enteritis mixed infection according to claim 1, it is characterized in that: this Chinese medicine composition is formed by the active fraction preparation of following weight portion: Herba Cirsii 40-50 part, Herba Artemisiae Annuae 30-45 part, Radix Astragali 15-25 part, Rhizoma Atractylodis Macrocephalae 15-25 part, Radix Glycyrrhizae 10-20 part.
3. the Chinese medicine composition for control coccidiosis of domestic fowls and necrotic enteritis mixed infection according to claim 2, it is characterized in that: this Chinese medicine composition is formed by the active fraction preparation of following weight portion: Herba Cirsii 40-50 part, Herba Artemisiae Annuae 30-40 part, Radix Astragali 20-25 part, Rhizoma Atractylodis Macrocephalae 20-25 part, Radix Glycyrrhizae 15-20 part.
4. each described Chinese medicine composition for control coccidiosis of domestic fowls and necrotic enteritis mixed infection according to claim 1-3, it is characterized in that: this Chinese medicine composition is powder, granule or oral liquid.
5. each described Chinese medicine composition for control coccidiosis of domestic fowls and necrotic enteritis mixed infection according to claim 1-3, it is characterized in that: described poultry is laying hen, broiler, turkey, goose and Carnis Coturnicis japonicae.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1223882A (en) * | 1998-01-20 | 1999-07-28 | 曹丽文 | Immunization powder |
| CN1391826A (en) * | 2002-07-02 | 2003-01-22 | 王跃庆 | Formula of Chinese herbal medicine for chicken |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1223882A (en) * | 1998-01-20 | 1999-07-28 | 曹丽文 | Immunization powder |
| CN1391826A (en) * | 2002-07-02 | 2003-01-22 | 王跃庆 | Formula of Chinese herbal medicine for chicken |
Non-Patent Citations (4)
| Title |
|---|
| 中草药防治鸡、兔球虫病的研究进展;卢福庄等;《浙江农业学报》;20070531;第19卷(第03期);253-257 * |
| 中草药防治鸡球虫常见方剂;舒刚;《动物保健》;20070131(第01期);32 * |
| 卢福庄等.中草药防治鸡、兔球虫病的研究进展.《浙江农业学报》.2007,第19卷(第03期), |
| 舒刚.中草药防治鸡球虫常见方剂.《动物保健》.2007,(第01期), |
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