CN1028400C - Smoking giving up chewing gum preparing process - Google Patents
Smoking giving up chewing gum preparing process Download PDFInfo
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- CN1028400C CN1028400C CN 92100464 CN92100464A CN1028400C CN 1028400 C CN1028400 C CN 1028400C CN 92100464 CN92100464 CN 92100464 CN 92100464 A CN92100464 A CN 92100464A CN 1028400 C CN1028400 C CN 1028400C
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- nicotine
- complex compound
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Abstract
The present invention relates to the preparation of oral gum for smoking cessation. On the basis of nicotine substitution therapy, the present invention adds additives so as to mitigate the burning sensation of nicotine for throats, and the smell of cigarettes is changed into insipidity and astringent taste so as to reinforce the determination of the smoking cessation of smokers from psychology; nicotine contents in each candy are the same as those of one cigarette, the absorption speed and the release speed of each candy are different from those of one cigarette, and thus, compared with the gradient of a peak value of nicotine concentration during smoking, the gradient of a peak value of nicotine concentration in blood is greatly reduced. The oral gum only plays the pharmacologic therapeutic effect on the block of abstinence syndromes without addiction. The present invention combines cationic resin of which the granularity is large and nicotine so as to prepare the oral gum; when people chew the oral gum, the release speed of the nicotine is accelerated, and thus, the present invention enhances the pleasant sensation of simulating the smoking, and is more favourable for the smoking cessation.
Description
The present invention relates to the smoking give-up chewing gum preparation field.
Smoking is not only harmful to the smoker, and endangers other people health, and therefore smoking cessation is advocated by national governments and health composition always.China is a smoking big country, and smoking population 2.4～2.7 hundred million add the involuntary smoker, up to 700,000,000 more than, China has multiple smoking cessation articles for use on the market at present, but effect is all undesirable, its reason is the basic theory of smoking addiction is understood very few, therefore is difficult to make desirable smoking cessation product.Abroad the reason to smoking addiction has been carried out extensive studies at the beginning of 1970's.The later stage seventies begins to form complete tobacco addiction theory, think the smoking cessation difficulty be because: 1. social psychology factor.2. pharmacology factor-promptly to nicotine dependence.Long-term smoking makes the smoker rely on cigarette psychologically, simultaneously nicotine has been produced physical dependence.In case smoking stops, the excitement and the inhibitory action of brain stem ascending reticular activing system all weaken, and therefore produce, distraction, insomnia fidgety such as anxiety, constrain, symptom such as indigestion, are called withdrawal syndrome, and it is lasting that smoking cessation is difficult to, and recurrence rate is high.
Just proposed to substitute cigarette with the nicotine chewing-gum as far back as the Fernce of Sweden in 1974, he proposes the pH of chewing-gum is adjusted to more than 7 to alleviate nicotine to pharyngeal burn feeling.Next year (1975) he propose a chewing-gum pH again and be adjusted to about 5 and alleviate pharyngeal burn feeling, and drum in this point.In fact all fail to solve the burn feeling of eater in pharyngeal generation.Britain tobacco research association is in the eighties a large amount of animals of process and human trial, and the data that drawn think that chewing-gum pH should be between 8.5～10.
Since the eighties, carried out Nicotine replacement therapy abroad, made smoking cessation obtain remarkable effect.But the shortcoming of Nicotine replacement therapy is not have psychologic therapeutic action, and the ES is when smoking cessation, and is also very strong to the temptation of cigarette psychologically.
The objective of the invention is to, on the basis of Nicotine replacement therapy, develop a kind of safe, convenient, effective, be easy to accept and the smoking cessation product that combines with pharmacology of the psychology that also tallies with the national condition of price into the ES.
The measure that the present invention taked is: 1, buffering is to selecting sodium carbonate and sodium acid carbonate for use; Or sodium phosphate and sodium hydrogen phosphate; Or sodium phosphate and sodium acid carbonate; Or calcium hydroxide and sodium acid carbonate composition, weight ratio accounts for 2～8% of chewing-gum, makes the pH value remain on 8.5～10, improves 150% so that nicotine discharges absorptivity.2, use Radix Glycyrrhizae and two kinds of compositions of peppermint, to alleviate pharyngeal burn feeling.3, make that nicotine content is 2mg in the every chewing gum, be equivalent to nicotine content in the cigarette, and absorb, rate of release is 10～20 minutes (sucking a cigarette is 7 minutes).Reach the blood level peak value and be 30 minutes, nicotine concentration peak value gradient only is 20% of smoking in (smoking is 5 minutes) blood.Therefore this chewing-gum is safe, and only plays the pharmacological treatment effect of blocking-up withdrawal syndrome, can habituation.4, with reference to the prescription that does not use clearly zhigancao decoction treatment meconism, the present invention selected for use Radix Glycyrrhizae, cassia twig, the tuber of dwarf lilyturf, peppermint totally four kinds of compositions as the additive of chewing gum for giving-up smoking.They play two kinds of effects, the alkaloidal corticoid effect of Radix Glycyrrhizae can be strengthened the effect of Nicotine replacement therapy treatment withdrawal syndrome on the one hand, the nourishing yin effect of the tuber of dwarf lilyturf also can make canker sore, sense of discomfort when smoking cessation such as getting angry alleviates, and Radix Glycyrrhizae, peppermint can alleviate in the chewing-gum nicotine to pharyngeal burn feeling.Smoke was thin out when in addition, the comprehensive function of four kinds of compositions also can make smoking, change is puckery.Thereby the pleasant sensation when making the smoker lose smoking makes the smoker strengthen the resolution of giving up smoking psychologically.5, selecting granularity for use is that 100 orders～200 purpose resin cations combine with nicotine, and the chewing-gum of making release of nicotine when chewing speeds up, and has strengthened the pleasant sensation of smoking-simulating.
The composition of chewing gum for giving-up smoking and proportioning (by weight percentage) are:
Matrix 15～19
Icing Sugar 57.4～58
Corn syrup 8～12
Nicotine ionic complex 0.4
Buffering is to 2～8
Additive 10
The preparation technology of chewing gum for giving-up smoking:
One, nicotine ion-exchange complex compound.
The resin that we select for use is: nontoxic, do not contain peculiar smell, be insoluble to the cationic ion-exchange resin of saliva, as have the weak-acid cation-exchange resin of acrylic functional group; The storng-acid cation exchange resin that has the sulphur base; The middle strong acidity cationic ion-exchange resin that has phosphate.Resin size requires between 100 orders～200 orders, with commercial resins (granularity is mostly more than 0.3mm), to smash with tissue refiner, temperature must not be above 100 ℃ in the process, and after peracid, alkali, ethanol processing processing, can come into operation, concrete preparation method is as follows:
1. commercial resins is removed supernatant with 75～95% alcohol immersion hypsokinesis in 24 hours, do not distinguish the flavor of to there being ethanol with water rinse, with resin transfer to exchange column, NaOH solution flushing with 2～8% is alkalescence to flowing out liquid, soaking after 3～4 hours, is neutral with deionized water rinsing to flowing out liquid, and the hydrochloric acid flushing that washed resin is continued with 2～8% is acid to flowing out liquid, soak after 3～4 hours, be neutral to flowing out liquid with deionized water rinsing.
2. behind above-mentioned acid, the alkali operation triplicate, put into tissue refiner and add water and blend, dried 100 mesh sieve, the resin after sieving continues with alcohol immersion 24 hours, the supernatant that inclines, with deionized water rinsing to not having the ethanol smell, repetitive operation one time, dry, cross 100 mesh sieve.Can use through the resin after the above-mentioned processing.
Above-mentioned preparation technology's effect is the impurity and the residue of sneaking in the resin in order to clean.
Contain nicotine 20%(weight ratio) the preparation technology of complex compound: take by weighing the 80g resin, it is pure heavy to add 20g() nicotine, the 500ml deionized water stirred 1 hour on magnetic stirrer at least, this complex compound is filtered, and it is dry in 20 ℃ of drying boxes, cross 100 mesh sieve, promptly obtain 20% nicotine ion-exchange complex compound.
In four kinds of plant compositions: Radix Glycyrrhizae accounts for 20～30%, and peppermint accounts for 60～40%, and cassia twig accounts for 10～15%, accounts for 10～15% the tuber of dwarf lilyturf, and above-mentioned percentage is weight percentage.
Two, the preparation method of four kinds of compositions:
1. the Radix Glycyrrhizae chopping is soaked, and adds sulfuric acid (analyzing pure) and to the pH1.8 precipitation separation, removes clear water.Use running water and wash repeatedly, after sulfuric acid is removed, with 20～30% ammoniacal liquor be neutralized to the pH7.0 heating, concentrated, drying is ground into 100 orders～200 order fine powders.
2. peppermint, cassia twig, the tuber of dwarf lilyturf, clean back oven dry under 55 °～65 ℃ and be ground into 100 orders～200 order fine powders.
Three, the embodiment of chewing gum for giving-up smoking preparation:
Example 1:
1. 434g nature matrix is added and have in the mixing kettle that has the hot jacket bag of agitator mixing kettle water Steam Heating, 15 pounds of (1.05kg/cm approximately per square inch
2) water vapour, matrix is interrupted upset, stir.After the complete melting of matrix, logical cold water is cooled to 85 ℃.
2. be added in the matrix of melting with 840g Icing Sugar (100 order) and 276g corn syrup (45 ° of Baumes), mixed about 15 minutes, this moment, whole mixture temperature was reduced to 60 ℃.
3. use the 610g Icing Sugar, 10g nicotine ion-exchange complex compound, the 250g additive, 60g sodium carbonate and 20g sodium acid carbonate (being 100 orders) mix as powder and are added in the mixture of melting in the pot, stirred 5 minutes, nicotine ion-exchange complex compound and buffer uniformity are distributed in the mixture, and temperature is 75 ℃ when adding complex compound.
4. with 2,3 two mixing, the time is approximately 20 minutes, and temperature is reduced to 40 ℃ in the mixing kettle at this moment.
5. moulding and packing:
(1) the hot temperature of shaping extruder is applied mechanically the heating of 45～50 ℃ of hot water, and the matrix that is extruded will be smeared one deck in case cling feeder cylinder and cutting machine with starch or candy sugar powder or the two mixture.Cylinder is pressed into certain thickness with matrix, and cutting machine keeps 20 ℃～30 ℃ work down.
(2) the thick 2mm of the every length of a film 70mm of packing
Wide 20mm
Weight 2.5g/ sheet
5 of every inner wrappings whenever close totally 100 of 20 inner wrappings.
(3) storage temperature is preferably in 18 °～20 ℃ relative humidity 45～50%.
Example 2
1.(with example 1)
2. be added in the matrix of melting with 830g Icing Sugar (100 order) and 276g corn syrup (45 ° of Baumes), mixed about 15 minutes, this moment, whole mixture temperature was reduced to 70 ℃.
3. use the 620g Icing Sugar, 10g nicotine ion-exchange complex compound, the 250g additive, 62.5g sodium phosphate and 25g sodium hydrogen phosphate (being 100 orders) mix as powder and are added in the mixture of melting in the pot, stir about 5 minutes, the temperature when adding complex compound is 70 ℃.
4. the temperature in the mixing kettle is reduced to 50 ℃, and all the other are with example 1.
5. with example 1.
Example 3,
1. with example 1.
2. be added in the matrix of melting with 822.5g Icing Sugar (100 order) and 276g corn syrup (45 ° of Baumes), mixed about 15 minutes, this moment, whole mixture temperature was reduced to 75 ℃.
3. use the 625g Icing Sugar, 10g nicotine ion-exchange complex compound, 250g additive, 50g calcium hydroxide and 25g sodium acid carbonate, (being 100 orders) mixes as powder and is added in the mixture of melting in the pot, stir about 5 minutes, and the temperature when adding complex compound is 68 ℃.
4. the temperature in the mixing kettle is reduced to 60 ℃ all the other is with example 1.
5. with example 1.
Advantage of the present invention:
1. all adopt domestic raw materials, low price, cost only are 1/10th of imported product, and price is suitable with general chewing gum.
2. the smoking-simulating mouthfeel is strong because the additive that adds has alleviated pharyngeal burn feeling, and the smoke when making smoking thin out, become puckery, like this, the smoker does not like smoking psychologically, is conducive to smoking cessation.
3. because the pH value is 8.5～10, the release that is conducive to nicotine absorbs, the nicotine level is higher in the blood, withdrawal syndrome when being conducive to block smoking cessation, simultaneously, the effect of additive can be strengthened again the effect of Nicotine replacement therapy treatment withdrawal syndrome, so this chewing-gum has the double action of pharmacology smoking cessation and psychology smoking cessation.
Claims (13)
1, the preparation technology of chewing gum for giving-up smoking, comprise and selecting materials, the melting matrix, the preparation of nicotine ion-exchange complex compound, with complex compound, buffering adds, chewing gum batching, stir, cooling, extrusion modling, packing makes finished product, it is characterized in that: additive is joined in the matrix of melting with the Icing Sugar that mixes, corn syrup after being uniformly mixed into powder with nicotine ion-exchange complex compound, buffering, mix and form, the composition of obtained chewing-gum and proportioning (by weight percentage) are:
Matrix 15～19
Icing Sugar 57.4～58
Corn syrup 8～12
Nicotine ion-exchange complex compound 0.4
Buffering is to 2～8
Additive 10
The preparation method of additive is:
The Radix Glycyrrhizae chopping is soaked, add analytical pure sulfuric acid, separate and form sediment to pH1.8, remove clear water, and wash repeatedly with running water, after sulfuric acid is removed, be neutralized to pH7.0 with ammoniacal liquor, heating, concentrate, drying is ground into 100 orders～200 order fine powders, again with peppermint, cassia twig, the tuber of dwarf lilyturf, the oven dry of washing back, be ground into 100 orders～200 order fine powders, with four kinds of compositions by weight percentage: Radix Glycyrrhizae 20～30, peppermint 60～40, cassia twig 10～15, mix the tuber of dwarf lilyturf 10～15, and the preparation technology of nicotine ion-exchange complex compound is:
Select for use nontoxic, do not contain peculiar smell, be insoluble to the acidic cationic resin of saliva, supernatant is removed in the hypsokinesis in 24 hours of alcohol immersion with 75～95%, do not distinguish the flavor of to there being ethanol with water rinse, with resin transfer to exchange column, NaOH solution flushing with 2～8% is alkalescence to flowing out liquid, soak after 3～4 hours, is neutral with deionized water rinsing to flowing out liquid, the hydrochloric acid flushing that washed resin is continued with 2～8% is acid to flowing out liquid, soaks after 3～4 hours, is neutral with deionized water rinsing to flowing out liquid, above-mentioned acid, behind the alkali operation triplicate, put into tissue refiner and add water, stir, dry, cross 100 mesh sieve, get the resin 80g that makes by weight percentage, add the pure heavy 20g of nicotine, the 500ml deionized water stirred 1 hour on magnetic stirrer at least, and this complex compound is filtered, and is dry in 20 ℃ of drying boxes, cross 100 mesh sieve, promptly obtain 20 percent nicotine ion-exchange complex compound.
2, by the said preparation technology of claim 1, it is characterized in that: buffering is to being that sodium carbonate and sodium acid carbonate add the chewing-gum mouth by 3: 1 mixing backs, and in every chewing-gum, its weight ratio is 2～8%.
3, by the said preparation technology of claim 1, it is characterized in that: buffering is to being sodium phosphate and sodium hydrogen phosphate, and its weight ratio is 2.5: 1.
4, by the said preparation technology of claim 1, it is characterized in that: buffering is to being calcium hydroxide and sodium acid carbonate, and its weight ratio is 2: 1.
5, by the said preparation technology of claim 1, it is characterized in that: with granularity be 100 purposes bufferings to Icing Sugar, nicotine ion-exchange complex compound, additive is uniformly mixed into powder, be added to Icing Sugar, corn syrup, in the mixture of melting matrix, stir after 20 minutes, the temperature of mixture is 40 °-60 ℃, and the temperature when adding complex compound is 68 °-75 ℃.
6, by the said preparation technology of claim 1, it is characterized in that: with the matrix moulding on shaping extruder that mixes, the hot temperature of extruder is applied mechanically 45～50 ℃ of hot water heating, matrix is smeared one deck with starch or candy sugar powder or the mixture of the two, be pressed into thick in the chewing-gum of 2mm, cut and grow into 70mm, wide is the sheet of 20mm, every heavy 2.5 grams.
7, by the said preparation technology of claim 1, it is characterized in that: the concentration of used ammoniacal liquor is 20～30%.
8, by the said preparation technology of claim 1, it is characterized in that: bake out temperature is 55 °～65 ℃.
9,, it is characterized in that by the said preparation technology of claim 1: selected resin cation also can be the storng-acid cation exchange resin that has the sulphur base or have phosphate in strong.Acid cation exchange resin or have the weak-acid cation-exchange resin of acrylic functional group.
10, by the said preparation technology of claim 1, it is characterized in that: in the nicotine complex compound, the granularity of resin is 100 orders～200 orders.
11, by the said preparation technology of claim 5, it is characterized in that: add nicotine ion-exchange complex compound, it is right to cushion, and additive mixes in the stirring, and the time of stirring is no less than 5 minutes.
12, by the said preparation technology of claim 5, it is characterized in that: the temperature when adding nicotine ion-exchange complex compound should be controlled at 68 °～75 ℃.
13, by claim 1 or 6 said preparation technologies, it is characterized in that: storage temperature is 18 °～20 ℃, and relative humidity is 45～50%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92100464 CN1028400C (en) | 1992-01-25 | 1992-01-25 | Smoking giving up chewing gum preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92100464 CN1028400C (en) | 1992-01-25 | 1992-01-25 | Smoking giving up chewing gum preparing process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1074583A CN1074583A (en) | 1993-07-28 |
| CN1028400C true CN1028400C (en) | 1995-05-17 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 92100464 Expired - Fee Related CN1028400C (en) | 1992-01-25 | 1992-01-25 | Smoking giving up chewing gum preparing process |
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| Country | Link |
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| CN (1) | CN1028400C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972256A (en) * | 2010-10-08 | 2011-02-16 | 同济大学 | Smoking cessation chewing gum capable of protecting oral mucosa |
| CA3061122C (en) * | 2013-07-11 | 2023-10-17 | Alexza Pharmaceuticals, Inc. | Nicotine salt with meta-salicylic acid |
| CN106974252B (en) * | 2016-01-18 | 2020-12-01 | 北京平和利科技有限公司 | Chewing salt threshold tablet and manufacturing method thereof |
| CN106578316A (en) * | 2016-12-20 | 2017-04-26 | 大连丹特生物技术有限公司 | Nicotine and xylitol chewing gum and preparation method thereof |
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1992
- 1992-01-25 CN CN 92100464 patent/CN1028400C/en not_active Expired - Fee Related
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| Publication number | Publication date |
|---|---|
| CN1074583A (en) | 1993-07-28 |
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