CN102839115A - Fermentation tank air intake device with filter - Google Patents
Fermentation tank air intake device with filter Download PDFInfo
- Publication number
- CN102839115A CN102839115A CN2011103005060A CN201110300506A CN102839115A CN 102839115 A CN102839115 A CN 102839115A CN 2011103005060 A CN2011103005060 A CN 2011103005060A CN 201110300506 A CN201110300506 A CN 201110300506A CN 102839115 A CN102839115 A CN 102839115A
- Authority
- CN
- China
- Prior art keywords
- filter
- air intake
- inlet pipe
- air
- fermentation tank
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/26—Conditioning fluids entering or exiting the reaction vessel
Landscapes
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention discloses a fermentation tank air intake device with a filter, belonging to the technical field of fermentation and filtration. The fermentation tank air intake device with the filter is characterized by comprising an air inlet pipe, wherein the air inlet pipe is connected with a fermentation tank pipeline, the upper edge of the air inlet pipe is sequentially provided with a coarse filter and a precision filter along air intake direction, an air intake pipeline of the precision filter is connected with a steam filter, the steam filter is connected with an external steam source, and pipelines between the steam filter and the precision filter, between the coarse filter and the precision filter and between the precision filter and the fermentation tank are respectively provided with an air intake control valve. The invention aims at providing a fermentation tank air intake device with a compact structure and a good filtering effect, used for air filtering.
Description
Technical field
The present invention relates to a kind of diffuser, more particularly, relate in particular to a kind of diffuser with strainer.
Background technology
Kang Baiting, chemical name are (S)-2-Methyl Butyric Acid-(1S, 7S, 8S; 8aR)-1,2,3,7; 8,8a-six hydrogen-7-methyl-8-{2-[(2R, 4R)-4-hydroxyl-6-oxo-2H-THP trtrahydropyranyl]-ethyl }-1-naphthalene ester, it is a kind of blood lipid regulation medicine; Through suppress the HMG-CoA reductase enzyme competitively, reduce the effect of this enzyme in the SUV building-up process, thereby it is synthetic to suppress SUV, total cholesterol density of blood plasma is descended.Because the verivate pravastatin of Kang Baiting has the stronger property of medicine aspect reducing cholesterol, Kang Baiting is generally as the starting material of pravastatin.
Kang Baiting is the metabolic secondary metabolite of microbial fermentation, and its fermentation production process adopts the mode of second order fermentation or three grade fermemtation to produce usually.The health hundred spit of fland fermentative prodn of our company adopt the mode of second order fermentation, and through the good health hundred spit of fland mycelium of seed tank culture, culture transferring continues to cultivate in fermentor tank, makes it fermentative prodn and obtains Kang Baiting.In the health hundred spit of fland fermentation culture processes, need a large amount of air to feed in the fermentor tank,, feed the upgrowth situation that the interior Air quality of fermentor tank directly influences mycelia for mycelia normal growth in the fermentor tank provides sufficient dissolved oxygen.Yet,, maybe airborne mikrobe be brought in the fermentor tank, thereby cause the fermentor tank microbiological contamination if the purifying air that feeds in the fermentor tank is not thorough.The harm that the fermentation culture microbiological contamination possibly bring comprises: assorted bacterium consumes fermention medium, influence jar interior normal mycelial growth; Assorted bacterium metabolism is also discharged unknown impuritie (or even deleterious impurity) and is influenced quality product, brings potential safety hazard to the patient.Therefore, for medical production industry, waste treatment behind the high-temperature sterilization is generally adopted in the processing of microbiological contamination fermented liquid, finally causes enormous economic loss, has increased the weight of production cost.
Existing health hundred spit of fland fermentor tank inlet systems; Form by a common filter paper air filter and an air distribution pipe that stretches in the fermentor tank; Wherein, air filter be provided with through the filtering compressed air inlet of total filter, the outlet of steam-in, filtrated air and sewage draining exit; The fixing welding of air distribution pipe leading portion and fermentor walls; Air distribution pipe stage casing and back segment are distributed in the fermentor tank; And air distribution pipe stage casing is near the fermentor tank inwall and perpendicular at the bottom of the jar; Air distribution pipe back segment is bending, and the end of air distribution pipe rear end is positioned at nearly middle position at the bottom of the fermentor tank.Not enough below these health hundred spit of fland fermentor tank inlet systems exist:
At first, common filter paper air filter is thorough inadequately to airborne microbe filter, and the fermented liquid microbiological contamination takes place easily, causes the fermentation failure;
Secondly, for improving bacteria-eliminating efficacy, common filter paper air filter adopts the filter material number of plies and the mode of dwindling aperture of filter material of increasing usually; But can cause the air system resistance to increase; Total pressure drop is generally 0.05-0.07MPa, thereby increases the load of whole filtering system, has improved energy consumption cost;
At last, the bend pipe position of air distribution pipe forms the corner or spot as yet untouched by a clean-up campaign easily because of the inconvenient clean operation of angle of bend is arranged, and causes fermented feed liquid residual, causes the fermented liquid microbiological contamination, causes the fermentation failure.
Summary of the invention
The objective of the invention is to deficiency, the diffuser of the band strainer of a kind of compact construction, good filtration effect is provided to above-mentioned prior art.
Technical scheme of the present invention is achieved in that a kind of diffuser with strainer; Comprise inlet pipe; Inlet pipe is connected with the fermentor tank pipeline; Wherein said inlet pipe upper edge airintake direction is provided with coarse filter and accurate filter in regular turn, and the inlet mouth pipeline of accurate filter is connected with vapor filter, and vapor filter is connected with the external steam source; Between vapor filter and the accurate filter, be equipped with air intake control valve between coarse filter and the accurate filter and on the pipeline between accurate filter and the fermentor tank.
In the diffuser of above-mentioned band strainer, described inlet pipe end is connected with the air distribution pipe, and the air distribution pipe is along the parallel distribution of fermentor tank inwall.
In the diffuser of above-mentioned band strainer, described coarse filter and accurate filter bottom are equipped with wash water valve.
In the diffuser of above-mentioned band strainer, be equipped with tensimeter on described coarse filter and the accurate filter.
After the present invention adopts said structure, replace existing filter-paper filter, effectively improved degerming efficient, guarantee that filter back air reaches aseptic, accomplish double insurance, avoided crossed contamination, meet the GMP requirement of pharmaceutical production through fine filter and accurate filter; Further, through vapor filter is set, guarantee fine filter or prefilter to be carried out steam sterilizing with clean steam.
Description of drawings
Below in conjunction with the embodiment in the accompanying drawing the present invention is done further detailed description, but do not constitute any restriction of the present invention.
Fig. 1 is a structural representation of the present invention.
Among the figure: inlet pipe 1, fermentor tank 2, coarse filter 3, accurate filter 4, vapor filter 5, air intake control valve 6, air distribution pipe 7, wash water valve 8, tensimeter 9.
Embodiment
Consult shown in Figure 1; A kind of diffuser of the present invention with strainer; Comprise inlet pipe 1; Inlet pipe 1 is connected with fermentor tank 2 pipelines, is provided with coarse filter 3 and accurate filter 4 in regular turn at inlet pipe 1 upper edge airintake direction, is equipped with wash water valve 8 in coarse filter 3 and accurate filter 4 bottoms; On coarse filter 3 and accurate filter 4, be equipped with tensimeter 9; The inlet mouth pipeline of accurate filter 4 is connected with vapor filter 5, and vapor filter 5 is connected with the external steam source; Between vapor filter 5 and the accurate filter 4, be equipped with air intake control valve 6 between coarse filter 3 and the accurate filter 4 and on the pipeline between accurate filter 4 and the fermentor tank 2; Be connected with air distribution pipe 7 at inlet pipe 1 end, air distribution pipe 7 is along the parallel distribution of fermentor tank 2 inwalls.
During concrete the use,, at first handle through coarse filter 3 through the filtering pressurized air of air total filter; Handle through accurate filter 4 again, get in the fermentor tank 2 by air distribution pipe 7 backs at last, wherein after coarse filter 3 is handled; Pressurized air reaches aseptic index (100 grades) basically, and accurate filter 4 is the high precision ultimate filter, and pressurized air is further purified; Its effect is to guarantee that filter back air reaches aseptic, accomplishes double insurance.Twice filtration of native system all reaches aseptic, but total pressure drop is merely 0.015-0.02MPa, less than the 0.05-0.07MPa of traditional filter-paper filter, can reduce energy consumption to a certain extent thus.As required, prefilter 2 can separately be sterilized with fine filter 4, improves the service efficiency of strainer; Simultaneously, vapor filter 5 can carry out steam sterilizing to fine filter 4, also can carry out steam sterilizing to coarse filter 3; Wherein the filtration filter material of coarse filter 3 is a spun glass, and filtration efficiency 99.99% (0.5 μ m) has characteristics such as filtration efficiency height, dust containing capacity be big; The filtration filter material of accurate filter 4 is poly tetrafluoroethylene and poly tetrafluoroethylene, has that hydrophobicity is strong, filtering accuracy is high (0.01 μ m, 99.9999%), characteristics such as pressure drop is low, heatproof is high, long service life; Vapor filter 5 mainly is made up of housing and filter core, and the filter core material is tetrafluoroethylene (powder sintered), and filtering accuracy 1 μ m has advantages such as high temperature resistant, corrosion-resistant, renewable processing.
The present invention can improve degerming efficient, reduction air-purification system pressure falls, thereby effectively cuts down the consumption of energy, and does not have the corner or spot as yet untouched by a clean-up campaign.
Claims (4)
1. diffuser with strainer; Comprise inlet pipe (1); Inlet pipe (1) is connected with fermentor tank (2) pipeline, it is characterized in that, described inlet pipe (1) upper edge airintake direction is provided with coarse filter (3) and accurate filter (4) in regular turn; The inlet mouth pipeline of accurate filter (4) is connected with vapor filter (5), and vapor filter (5) is connected with the external steam source; Between vapor filter (5) and the accurate filter (4), be equipped with air intake control valve (6) between coarse filter (3) and the accurate filter (4) and on the pipeline between accurate filter (4) and the fermentor tank (2).
2. the diffuser of band strainer according to claim 1 is characterized in that, described inlet pipe (1) end is connected with air distribution pipe (7), and air distribution pipe (7) is along the parallel distribution of fermentor tank (2) inwall.
3. the diffuser of band strainer according to claim 1 and 2 is characterized in that, described coarse filter (3) and accurate filter (4) bottom are equipped with wash water valve (8).
4. the diffuser of band strainer according to claim 3 is characterized in that, is equipped with tensimeter (9) on described coarse filter (3) and the accurate filter (4).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103005060A CN102839115A (en) | 2011-10-09 | 2011-10-09 | Fermentation tank air intake device with filter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103005060A CN102839115A (en) | 2011-10-09 | 2011-10-09 | Fermentation tank air intake device with filter |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102839115A true CN102839115A (en) | 2012-12-26 |
Family
ID=47366835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011103005060A Pending CN102839115A (en) | 2011-10-09 | 2011-10-09 | Fermentation tank air intake device with filter |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102839115A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105032044A (en) * | 2015-08-19 | 2015-11-11 | 南通荣泰生物科技有限公司 | Reaction environment control system in amino acid production process |
| CN111662803A (en) * | 2020-06-11 | 2020-09-15 | 中农新科(苏州)有机循环研究院有限公司 | Gas-liquid circulation system of airlift fermentation tank |
| CN111979093A (en) * | 2020-08-28 | 2020-11-24 | 甘文涛 | Enzyme preparation apparatus for producing |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101543710A (en) * | 2009-03-27 | 2009-09-30 | 镇江科海生物工程设备有限公司 | Air filtering system of biological fermentation equipment |
| CN102206575A (en) * | 2011-03-30 | 2011-10-05 | 常州三高生物技术工程设备有限公司 | Fermenter |
| CN202089970U (en) * | 2011-06-20 | 2011-12-28 | 广东蓝宝制药有限公司 | Air inlet system of Compactin fermentation tank |
-
2011
- 2011-10-09 CN CN2011103005060A patent/CN102839115A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101543710A (en) * | 2009-03-27 | 2009-09-30 | 镇江科海生物工程设备有限公司 | Air filtering system of biological fermentation equipment |
| CN102206575A (en) * | 2011-03-30 | 2011-10-05 | 常州三高生物技术工程设备有限公司 | Fermenter |
| CN202089970U (en) * | 2011-06-20 | 2011-12-28 | 广东蓝宝制药有限公司 | Air inlet system of Compactin fermentation tank |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105032044A (en) * | 2015-08-19 | 2015-11-11 | 南通荣泰生物科技有限公司 | Reaction environment control system in amino acid production process |
| CN111662803A (en) * | 2020-06-11 | 2020-09-15 | 中农新科(苏州)有机循环研究院有限公司 | Gas-liquid circulation system of airlift fermentation tank |
| CN111979093A (en) * | 2020-08-28 | 2020-11-24 | 甘文涛 | Enzyme preparation apparatus for producing |
| CN111979093B (en) * | 2020-08-28 | 2023-11-17 | 北京盛拓达生物技术有限公司 | Enzyme preparation apparatus for producing |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102174395B (en) | Automation augmentation and culture system of induced pluripotent stem cells | |
| JP5893051B2 (en) | Alternating pneumatic membrane cell separation system | |
| CN104436815B (en) | The liquid continuous feeding device of Pneumatic constant pressure and method | |
| CN102839115A (en) | Fermentation tank air intake device with filter | |
| CN104004645A (en) | Two-phase system and method for organic wastewater hydrolytic acidification coupled microalgae culture | |
| CN202297588U (en) | Fermentation tank air intake device with filters | |
| CN108165481A (en) | A kind of public health preventive medicine collection bacterium detection device | |
| CN202089970U (en) | Air inlet system of Compactin fermentation tank | |
| CN209162055U (en) | A kind of microbe research culture apparatus | |
| CN107935656A (en) | Organic waste slurry fermentation vat | |
| CN101935614A (en) | Continuous fermentation and separation coupling bioreactor | |
| CN201962286U (en) | Barm liquid processing system | |
| CN206735839U (en) | A kind of biological wastewater inactivation treatment device | |
| CN101045905A (en) | Domesticated and selectively bred autoflocculating yeast mutant plant and its application | |
| CN103952306B (en) | A kind of fermentor tank using ultrasonic wave froth breaking | |
| CN103222538A (en) | Method for recycling low-threonine-content ceramic membrane dialysate | |
| CN202006066U (en) | Microporous ceramic air filter for biological fermentation | |
| CN204111735U (en) | A kind of fermentation system with thalli separation facility | |
| CN2675680Y (en) | Liquid bacterial preparing bank | |
| CN208791604U (en) | A kind of vinegar production installation for fermenting | |
| CN203842460U (en) | Improved aerobic fermentation air purification device | |
| CN109609354A (en) | A kind of illumination fermentation tank suitable for industrialized production | |
| CN108239599B (en) | Air bacteria sampling, culturing and detecting integrated device | |
| CN207632798U (en) | A kind of microorganism separation verifying attachment | |
| CN1277456C (en) | Method and apparatus for producing and inoculating liquid bacterial spawn in oxygenating mode |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20121226 |