CN102827162A - Preparation method of 2-methyl-7-azaindole - Google Patents
Preparation method of 2-methyl-7-azaindole Download PDFInfo
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- CN102827162A CN102827162A CN2011101651650A CN201110165165A CN102827162A CN 102827162 A CN102827162 A CN 102827162A CN 2011101651650 A CN2011101651650 A CN 2011101651650A CN 201110165165 A CN201110165165 A CN 201110165165A CN 102827162 A CN102827162 A CN 102827162A
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Abstract
The invention relates to a preparation method of 2-methyl-7-azaindole. The method comprises the steps that: (1) 2-amino-3-methylpyridine is subjected to an acetic anhydride acylation reaction, such that 2-acetamido-3-methylpyridine is produced; and (2) 2-acetamido-3-methylpyridine is subjected to a cyclization reaction under the effects of sodium amide and N-methylaniline, such that 2-methyl-7-azaindole is produced. The method provided by the invention has the advantages of easy-to-obtain raw materials, relatively mild reaction conditions, easy control, high yield (wherein a total yield is higher than 60%), and low cost. The purity of the product 2-methyl-7-azaindole is high (wherein the purity is no lower than 99.5%). The product is suitable for industrialized productions.
Description
Technical field
The present invention relates to pharmaceutical chemistry, be specifically related to the preparation method of a kind of 2-methyl-7-azaindole.
Background technology
2-methyl-7-azaindole is in the synthetic at present new drug research-Dopamine Receptors suppressor factor class in midbody commonly used, its preparation method is mainly following:
Method one:
Sandham，David?A.et?al
Bioorganic&Medicinal?chemistry?Letter，19(16)，4794-4798；2009
Method two:
Armer，Richard?E.et?al.(GB?2422831)
Method three:
Estel，L.et?al.
Journal?of?Organic?Chemistry，53(12)，2740-4；1988
But above-mentioned these methods exist not enough, and like severe reaction conditions, temperature needs the very low temperature reaction, and raw material reagent costs an arm and a leg etc.Gao Shu etc. proposed following compound method (Gao, Shu et al.Organometallics, 17 (21), 4666-4674 in Organometallics in 1998; 1998):
But the reaction process of this method is fierce relatively, and working condition is harsh, and producing has certain risk; Reaction yield is quite low simultaneously.Therefore, need to seek better 2-methyl-7-azaindole preparation method.
Summary of the invention
Technical problem to be solved by this invention is to overcome above-mentioned weak point, and the research and design raw material is easy to get, reaction conditions is gentle relatively, is easy to control; The method for preparing 2-methyl-7-azaindole that reaction yield is high, cost is low.
The invention provides the preparation method of a kind of 2-methyl-7-azaindole.
The inventive method comprises the following steps:
(1) 2-amino-3-picoline generates 2-acetylaminohydroxyphenylarsonic acid 3-picoline through the aceticanhydride acylation reaction;
(2) ring-closure reaction generation 2-methyl-7-azaindole takes place in 2-acetylaminohydroxyphenylarsonic acid 3-picoline under the effect of sodium amide.
The inventive method reaction formula is following:
Acylation reaction described in the step (1) is carried out in toluene solvant, 20～110 ℃ of temperature, and the reaction times is 1～72h, wherein, the mol ratio of raw material 2-amino-3-picoline and aceticanhydride is 1: 1～3.Optimal reaction temperature is 60～80 ℃.
Ring-closure reaction carries out in the methylphenylamine solvent in the step (2).Temperature is 200～300 ℃, and the reaction times is 10～120min, and the mol ratio of 2-acetylaminohydroxyphenylarsonic acid 3-picoline and sodium amide is 1: 1～5.Mol ratio the best of 2-acetylaminohydroxyphenylarsonic acid 3-picoline and sodium amide is 1: 1～3.Optimal reaction temperature is 250～260 ℃.
Because adopt technique scheme, the present invention compared with prior art has following advantage:
The present invention is a raw material with 2-amino-3-picoline, obtains 2-methyl-7-azaindole through acidylate, ring-closure reaction successively.Reaction is the reaction of comparative maturity in the organic synthesis field, has that raw material is easy to get, reaction conditions is gentle relatively, is easy to control; Yield high (total recovery is greater than 60%) and the low advantage of cost; In addition, the present invention's operation is easier, the product 2-methyl that obtains-7-azaindole purity high (>=99.5%).Be suitable for suitability for industrialized production.
Embodiment
Below be specific embodiment of the present invention, technical scheme of the present invention is done further to describe, but the present invention be not limited to this embodiment.
Embodiment 1 2-methyl-7-azaindole preparation
(1) 2-amino-3-picoline generates 2-acetylaminohydroxyphenylarsonic acid 3-picoline through the aceticanhydride acylation reaction
In the 100L reaction kettle, add 2-amino-3-picoline 10Kg, toluene 40Kg and aceticanhydride 15Kg slowly are warming up to 60 ℃ of reactions, reaction 2h, HPLC Monitoring and Controlling raw material＜1%; Be cooled to 40 ℃, concentrating under reduced pressure reclaims toluene, and resistates is transferred to the 500L reaction kettle, adds the 100Kg shrend and goes out, and yellow soda ash transfers to pH10, dichloromethane extraction 50Kg * 3, united extraction liquid, saturated common salt water washing, anhydrous sodium sulfate drying, filtration; Filtrate decompression is concentrated into dried (recovery methylene dichloride), gets thick product 12.7Kg (92%).Thick product can directly drop into next step ring-closure reaction.Or slightly product is with 38.1Kg Virahol recrystallization, and temperature rising reflux dissolves clear, is cooled to 0 ± 2 ℃, keeps after 2 hours, filters, and drying gets product 10.1Kg and is 2-acetylaminohydroxyphenylarsonic acid 3-picoline, calculated yield 79.5%, purity (HPLC): 99.58%.
(2) ring-closure reaction generation 2-methyl-7-azaindole takes place in 2-acetylaminohydroxyphenylarsonic acid 3-picoline under the effect of sodium amide, methylphenylamine
In the 100L reaction kettle, add methylphenylamine 30Kg, sodium amide 6.4Kg slowly is warming up to backflow, reacted 0.5 hour, and 180 ℃ of controlled temperature, drip: the thick product 12Kg of 2-acetylaminohydroxyphenylarsonic acid 3-picoline is dissolved in the solution that is made in the 12KgN-monomethylaniline.200 ℃ of controlled temperature reacted 0.5 hour, heated up to steam methylphenylamine; Resistates is warming up to 250 ℃, reacts 0.5 hour, is cooled to 100 ℃; Drip 12Kg Glacial acetic acid min. 99.5/20Kg aqueous solution, in order to solubilizing reaction liquid, add stir half a hour after; Be cooled to room temperature, regulate pH＞10 with 5N sodium hydroxide; Dichloromethane extraction 50Kg * 3, united extraction liquid, saturated common salt water washing, anhydrous sodium sulfate drying, filtration; Filtrate decompression is concentrated into dried (recovery methylene dichloride), gets thick product 12Kg.Thick product is with activated carbon decolorizing, 36Kg ethyl alcohol recrystallization, and temperature rising reflux dissolves clear, is cooled to 0 ± 2 ℃, keeps after 2 hours, filters, and drying gets product 7.4Kg and is 2-methyl-7-azaindole, calculated yield 70.1%, purity (HPLC): 99.69%.
Claims (5)
1. the preparation method of 2-methyl-7-azaindole is characterized in that, this method comprises the following steps:
(1) 2-amino-3-picoline generates 2-acetylaminohydroxyphenylarsonic acid 3-picoline through the aceticanhydride acylation reaction;
(2) ring-closure reaction generation 2-methyl-7-azaindole takes place in 2-acetylaminohydroxyphenylarsonic acid 3-picoline under the effect of sodium amide, and reaction formula is following:
2. method according to claim 1 is characterized in that, said step (1) acylation reaction is carried out in toluene solvant, 20～110 ℃ of temperature, and the reaction times is 1～72h; The mol ratio of 2-amino-3-picoline and aceticanhydride is 1: 1～3.
3. method according to claim 2 is characterized in that, said step (1) acylation reaction temperature is 60～80 ℃.
4. method according to claim 1 is characterized in that, said step (2) ring-closure reaction carries out in the methylphenylamine solvent, and temperature is 200～300 ℃, and the reaction times is 10～120min; The mol ratio of 2-acetylaminohydroxyphenylarsonic acid 3-picoline and sodium amide is 1: 1～5.
5. method according to claim 4 is characterized in that, the mol ratio of said step (2) ring-closure reaction 2-acetylaminohydroxyphenylarsonic acid 3-picoline and sodium amide is 1: 1～3; Temperature of reaction is 250～260 ℃.
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| CN2011101651650A CN102827162A (en) | 2011-06-17 | 2011-06-17 | Preparation method of 2-methyl-7-azaindole |
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| CN2011101651650A CN102827162A (en) | 2011-06-17 | 2011-06-17 | Preparation method of 2-methyl-7-azaindole |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105646485A (en) * | 2016-03-01 | 2016-06-08 | 苏州艾缇克药物化学有限公司 | Synthesizing method of 7-azaindole |
| CN110343104A (en) * | 2019-08-27 | 2019-10-18 | 陈建江 | A kind of synthetic method of 2- methyl -7- azaindole |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998036035A1 (en) * | 1997-02-13 | 1998-08-20 | Queen's University At Kingston | Luminescent compounds and methods of making and using same |
| CN101704815A (en) * | 2009-11-27 | 2010-05-12 | 无锡好芳德药业有限公司 | Method for preparing azepine indole compounds |
-
2011
- 2011-06-17 CN CN2011101651650A patent/CN102827162A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998036035A1 (en) * | 1997-02-13 | 1998-08-20 | Queen's University At Kingston | Luminescent compounds and methods of making and using same |
| CN101704815A (en) * | 2009-11-27 | 2010-05-12 | 无锡好芳德药业有限公司 | Method for preparing azepine indole compounds |
Non-Patent Citations (2)
| Title |
|---|
| ERCULES E.S. TEOTONIO ET AL.: "Influence of the N-[methylpyridyl]acetamide ligands on the photoluminescent properties of Eu(III)-perchlorate complexes", 《POLYHEDRON》 * |
| SHU GAO ET AL.: "Highly Fluxional Blue Luminescent Aluminum Complexes: Al(CH3)(7-azain-2-Ph)2(7-azainH-2-Ph), Al3(í3-O)(CH3)3(7-azain-2-Ph)4, and Al3(í3-O)(CH3)3(7-azain-2-CH3)4 (7-azain ) 7-Azaindole Anion)", 《ORGANOMETALLICS》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105646485A (en) * | 2016-03-01 | 2016-06-08 | 苏州艾缇克药物化学有限公司 | Synthesizing method of 7-azaindole |
| CN110343104A (en) * | 2019-08-27 | 2019-10-18 | 陈建江 | A kind of synthetic method of 2- methyl -7- azaindole |
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Application publication date: 20121219 |