CN102813953B - Warming agent clathrate compound applied to absorbent products and preparation method for warming agent clathrate compound - Google Patents
Warming agent clathrate compound applied to absorbent products and preparation method for warming agent clathrate compound Download PDFInfo
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- CN102813953B CN102813953B CN201210294493.5A CN201210294493A CN102813953B CN 102813953 B CN102813953 B CN 102813953B CN 201210294493 A CN201210294493 A CN 201210294493A CN 102813953 B CN102813953 B CN 102813953B
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- clathrate
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- clathrate compound
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- 239000002250 absorbent Substances 0.000 title claims abstract description 26
- 230000002745 absorbent Effects 0.000 title claims abstract description 26
- 238000010792 warming Methods 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 150000001875 compounds Chemical class 0.000 title claims abstract description 8
- 239000003795 chemical substances by application Substances 0.000 title abstract description 9
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229920000858 Cyclodextrin Polymers 0.000 claims abstract description 16
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 8
- 239000000243 solution Substances 0.000 claims description 8
- 239000007864 aqueous solution Substances 0.000 claims description 7
- 229920006395 saturated elastomer Polymers 0.000 claims description 7
- 238000001556 precipitation Methods 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 230000006837 decompression Effects 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 238000004321 preservation Methods 0.000 claims description 5
- 230000008961 swelling Effects 0.000 claims description 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 3
- -1 vanillyl ether compound Chemical class 0.000 abstract description 13
- 230000035807 sensation Effects 0.000 abstract description 11
- 230000009286 beneficial effect Effects 0.000 abstract description 8
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract description 7
- 235000012141 vanillin Nutrition 0.000 abstract description 3
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 abstract description 3
- NLDDIKRKFXEWBK-AWEZNQCLSA-N gingerol Chemical compound CCCCC[C@H](O)CC(=O)CCC1=CC=C(O)C(OC)=C1 NLDDIKRKFXEWBK-AWEZNQCLSA-N 0.000 abstract description 2
- JZLXEKNVCWMYHI-UHFFFAOYSA-N gingerol Natural products CCCCC(O)CC(=O)CCC1=CC=C(O)C(OC)=C1 JZLXEKNVCWMYHI-UHFFFAOYSA-N 0.000 abstract description 2
- 235000002780 gingerol Nutrition 0.000 abstract description 2
- 239000003921 oil Substances 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- 229910052799 carbon Inorganic materials 0.000 description 8
- 125000004432 carbon atom Chemical group C* 0.000 description 8
- VLDFMKOUUQYFGF-UHFFFAOYSA-N 4-(butoxymethyl)-2-methoxyphenol Chemical compound CCCCOCC1=CC=C(O)C(OC)=C1 VLDFMKOUUQYFGF-UHFFFAOYSA-N 0.000 description 7
- 229940078465 vanillyl butyl ether Drugs 0.000 description 7
- 125000000217 alkyl group Chemical group 0.000 description 6
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 125000003342 alkenyl group Chemical group 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 4
- 210000004400 mucous membrane Anatomy 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 235000017663 capsaicin Nutrition 0.000 description 3
- 229960002504 capsaicin Drugs 0.000 description 3
- XJQPQKLURWNAAH-UHFFFAOYSA-N dihydrocapsaicin Chemical compound COC1=CC(CNC(=O)CCCCCCC(C)C)=CC=C1O XJQPQKLURWNAAH-UHFFFAOYSA-N 0.000 description 3
- RBCYRZPENADQGZ-UHFFFAOYSA-N dihydrocapsaicin Natural products COC1=CC(COC(=O)CCCCCCC(C)C)=CC=C1O RBCYRZPENADQGZ-UHFFFAOYSA-N 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
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- 230000000638 stimulation Effects 0.000 description 3
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- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 description 3
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 2
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 2
- 150000001241 acetals Chemical class 0.000 description 2
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- 210000004877 mucosa Anatomy 0.000 description 2
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- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 239000008347 soybean phospholipid Substances 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 239000003981 vehicle Substances 0.000 description 2
- 229940015975 1,2-hexanediol Drugs 0.000 description 1
- BPIUIOXAFBGMNB-UHFFFAOYSA-N 1-hexoxyhexane Chemical compound CCCCCCOCCCCCC BPIUIOXAFBGMNB-UHFFFAOYSA-N 0.000 description 1
- AOPDRZXCEAKHHW-UHFFFAOYSA-N 1-pentoxypentane Chemical compound CCCCCOCCCCC AOPDRZXCEAKHHW-UHFFFAOYSA-N 0.000 description 1
- QGKBSGBYSPTPKJ-UZMKXNTCSA-N 2,6-di-o-methyl-β-cyclodextrin Chemical compound COC[C@H]([C@H]([C@@H]([C@H]1OC)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COC)[C@H]([C@@H]([C@H]3OC)O)O[C@H]3O[C@H](COC)[C@H]([C@@H]([C@H]3OC)O)O[C@H]3O[C@H](COC)[C@H]([C@@H]([C@H]3OC)O)O[C@H]3O[C@H](COC)[C@H]([C@@H]([C@H]3OC)O)O3)[C@H](O)[C@H]2OC)COC)O[C@@H]1O[C@H]1[C@H](O)[C@@H](OC)[C@@H]3O[C@@H]1COC QGKBSGBYSPTPKJ-UZMKXNTCSA-N 0.000 description 1
- LSKFRYMLGSVAPL-UHFFFAOYSA-N 4-[(4-hydroxy-3-methoxyphenyl)methoxymethyl]-2-methoxyphenol Chemical compound C1=C(O)C(OC)=CC(COCC=2C=C(OC)C(O)=CC=2)=C1 LSKFRYMLGSVAPL-UHFFFAOYSA-N 0.000 description 1
- 229920001450 Alpha-Cyclodextrin Polymers 0.000 description 1
- 206010006784 Burning sensation Diseases 0.000 description 1
- 206010012444 Dermatitis diaper Diseases 0.000 description 1
- 208000003105 Diaper Rash Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 244000273928 Zingiber officinale Species 0.000 description 1
- 235000006886 Zingiber officinale Nutrition 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 description 1
- 229940043377 alpha-cyclodextrin Drugs 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000008365 aqueous carrier Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
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- 238000007598 dipping method Methods 0.000 description 1
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- 239000003974 emollient agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 description 1
- 229940080345 gamma-cyclodextrin Drugs 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
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Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a warming agent clathrate compound applied to absorbent products. The clathrate compound is prepared by performing clathration on cyclodextrin or cyclodextrin derivatives for a warming agent. The warming agent comprises any one of a vanillyl ether compound, an amide compound and vanillin acetal or gingerol. The invention also discloses a preparation method for the warming agent clathrate compound. The invention has the beneficial effects that the absorbent products are warm and dry but are not scorching by using the warming agent clathrate compound disclosed by the invention, thus, the comfortable sensations of people using the absorbent products are enhanced.
Description
Technical field
The present invention relates to bag and thing that absorbing products is used, especially relate to a kind of clathrate that makes absorbent article user there is warmth sensation.
Background technology
The absorbing structure of most of kinds of now having designed not only for absorb body fluids as blood, urine, menstruation etc. be effectively, and sanitory while using.This based article generally comprises the primer of quilting material, absorbent cores and a kind of impermeable liquid of certain permeable body fluid.Now aspect the various shapes of this based article, size, thickness, improving, so that comfort and convenient more when their are used.
The known disposable absorbent article with the top flat that applies lotion, as diaper, sanitary towel, protective pad etc.Known polytype lotion can provide various skin beneficial effect, profit as prevention or treatment diaper rash.These lotions can be administered to as on the top flat of absorbent article, and can transfer in use on wearer's skin.
The wearer of disposable absorbent article likes the product that sensation beneficial effect can also be provided except fluid absorbency beneficial effect can be provided.The sensation beneficial effect of some wearer's expectations is to transmit warm dry and comfortable sensation to wearer.Therefore the absorbent article such as catamenial device is developed in expectation.
Attempted in the past mixing such as Rhizoma Zingiberis Recens quintessence oil in as catamenial device and transmitting a kind of warm sense at absorbent article, patent application CN201010281753.8 for example, in CN201010523910.X, CN201020582099.8.During for absorbent article, these materials are generally loaded into the top flat of product.But Rhizoma Zingiberis Recens quintessence oil has volatility highly, make this type of material in absorbent article be difficult to keep stable when transportation and storage, especially when when transporting and duration of storage is exposed to high temperature.In addition,, because Rhizoma Zingiberis Recens quintessence oil Odor stimulation is stronger, many consumers do not accept this abnormal smells from the patient.
Known in addition have many materials that warm sensation is provided when using and be called as warm dose or warm dose, the vanillyl ether compound being shown below:
Wherein R7 represents hydrogen atom or has 1-10 carbon atom, is the direct-connected of 1 ~ 6 carbon atom or collateralization alkyl or alkenyl in line with expectations.As example as Vanillyl butyl ether, vanillyl amyl ether, vanillyl ether, vanillyl hexyl ether etc.
The R7 that is preferably vanillyl ether compound is-C
4h
9butyl, be Vanillyl butyl ether.
-as shown in the formula generation the amides compound that shows:
Wherein R8 represents the alkyl or alkenyl of direct-connected or branching.As capsaicin ((E)-N-(4-hydroxyl-3-methoxybenzy)-8-methyl-6-nonenamide),
As dihydrocapsaicin (N-(4-hydroxyl-3-methoxybenzy)-8-methyl pelargonamide),
-as shown in the formula described vanillin acetal
In formula, R represents hydrogen atom, have the straight or branched alkyl of 1-9 carbon atom or have the straight or branched alkoxyl of 1-8 carbon atom.As example patent application 200680024516.3, be incorporated herein by reference in full.
-as shown in the formula described gingerol
As example as Rhizoma Zingiberis Recens extract, oil of ginger.
But these warm dose because zest is larger, cannot directly or simply by dilution, be applied to absorbing products.
Therefore, still expectation exploitation can provide to wearer the absorbent article product of warm dry and comfortable sensation beneficial effect, and described beneficial effect can not suffer stability problem when the transportation of absorbent article product and storage, and can be delivered to wearer's skin.
Summary of the invention
The present invention is based on this discovery, the wearing article contacting with skin and/or mucous membrane surface, comprises warm dose, not needing to change under the condition of ambient temperature, to user, provides warmth sensation and dry feeling.For a long time, wear this goods, to user, providing comfortable warm sense and dry feeling, and without any skin irritation sense or burning sensation.Object of the present invention is achieved by the following scheme: a kind of warm dose of being applied to absorbent article wraps and thing, and described bag and thing are that warm dose is made with cyclodextrin or cyclodextrin derivative enclose,
Described warm dose is selected from:
-vanillyl the ether compound that is shown below:
（1）
Wherein R7 represents hydrogen atom or has 1-10 carbon atom, is the direct-connected of 1 ~ 6 carbon atom or collateralization alkyl or alkenyl in line with expectations;
-as shown in the formula generation the amides compound that shows:
（2）
Wherein R8 represents the alkyl or alkenyl of direct-connected or branching;
(3) as shown in the formula described vanillin acetal
In formula, R represents hydrogen atom, have the straight or branched alkyl of 1-9 carbon atom or have the straight or branched alkoxyl of 1-8 carbon atom
-(4) gingerol;
Preferably, vanillyl etherate is Vanillyl butyl ether, i.e. 2-methoxyl group-4-(fourth oxygen methyl) phenol;
Preferably, amides compound is capsaicin or dihydrocapsaicin;
Capsaicin: (E)-N-(4-hydroxyl-3-methoxybenzy)-8-methyl-6-nonenamide
Dihydrocapsaicin: N-(4-hydroxyl-3-methoxybenzy)-8-methyl pelargonamide
Preferably, described warm dose is 1:1-1:10 with the ratio of weight and number of cyclodextrin, and described cyclodextrin is any in beta-schardinger dextrin-or alpha-cyclodextrin or gamma-cyclodextrin.
Preferably, described warm dose is 1:1-1:10 with the ratio of weight and number of cyclodextrin derivative, and described cyclodextrin derivative is any preferred in 2-hydroxy propyl-Beta cyclodextrin or 2,6-dimethyl-beta cyclodextrin or glucosyl group cyclodextrin;
The present invention also comprises the preparation method of warm dose of cyclodextrin clathrate, comprises the steps:
Cyclodextrin or cyclodextrin derivative are placed in to reactor and are heated to 50 ℃ and make above saturated aqueous solution; With warm dose of organic solvent dissolution, make warm agent solution, warm agent solution is slowly joined in reactor, continue heated and stirred 1-24h, filtered while hot or cooling standing rear filtration, obtain clathrate after being dried;
Described organic solvent is any in ethanol, propylene glycol, glycerol, PEG400.
Gained bag of the present invention and thing, can make an addition to various substrate and form bag and thing according to required appearance form, and described substrate includes but not limited to the forms such as cream frost, emulsion, gel, powder, dispersion.
In preparation bag of the present invention and thing, in described substrate, can comprise any composition that is applicable to the type bag and thing that is generally used for this area.As example, comprise emollient, plants essential oil, antibacterial, anti-sensitizer, plant extract etc.
Bag of the present invention can be applied to thing the disposable absorbent article contacting with skin and/or mucous membrane surface.The structure of disposable absorbent article is unimportant for reality of the present invention, typically comprises: the intransitable egative film of top flat, fluid that absorbent cores, fluid can pass through.This goods are preferably disposable absorbent article as diaper, urine pants, sanitary towel, protective pad, dry or wet wipes etc.
Warm dose of clathrate of the present invention is incorporated into absorbing products to be enough to send the amount of required warming sense.The goods of invention comprise that the amount of warm dose is enough to the temperature receptor in chafe and/or mucous membrane surface region, and the Surface Contact of these goods and skin and/or mucosa also transmits required warmth sensation thus.Because warm sense degree and the life-span difference with compound changes, thus with body skin with or every kind of goods contacting of mucous membrane surface wear amount of reagent and will change widely.Typically, goods of the present invention as disposable hygienic absorbent article at least a portion goods with every goods 0.01g/m
2to 300g/m
2, be preferably 0.05g to 200g/m
2, 0.08g/m more preferably
2to 100g/m
2.
The object of this invention is to provide warm dose of improvement, can or even improve skin and/or mucosa to skin and/or the lasting warm dry feeling of mucosal delivery, and entail dangers to security feature not.
Warm dose of bag of the present invention and thing can be incorporated in disposable absorbent article releasedly with diverse ways, be preferably bag and thing are incorporated in topsheet structures, and described method will be readily apparent to persons skilled in the art.For example warm dose of bag and thing can be present in aqueous carrier or volatile vehicle, as water, ethanol or analog or cream frost, washing liquid, microemulsion, gel, powder, by spraying, dipping, printing, soak or other modes contact absorbent material with thing and are applied on absorbent article with wrapping.
The invention has the beneficial effects as follows:
In warm dose of bag of the present invention and thing, typically can pass on warming sense to user, dry feeling, and without changing warm dose of bag and the applied extraneous local surfaces temperature of thing.
Warm dose of the present invention can be caused warm sense subjective sensation.This sensation is owing to the stimulation to cutaneous thermoreceptor.That is, can stimulate body temp sensor with chemical mode, and warming sense/dry feeling is provided thus, and without the temperature that changes body surface.
By the clathrate of cyclodextrin or cyclodextrin derivative, make warm sense send controlled carrying out, can not cause stimulations, scorching hot etc. uncomfortablely feel.Caused optimized warming sense, dry feeling, and the more lasting warming sense of transmissibility.
By cyclodextrin or cyclodextrin derivative enclose, make warm dose can exist with more stable form, warm dose of bag and the more application form of thing are provided, compatibility stability widely, also strengthen especially warm dose for heat treated stability in the absorbing products course of processing, also strengthened the stability that the absorbing products after application bag and thing is stored simultaneously.
The specific embodiment
Embodiment 1
Prepare clathrate, take beta-schardinger dextrin-10g and be placed in reactor, add 200ml water heated and stirred to beta-schardinger dextrin-all to dissolve, continue to be warming up to 55 ℃, make saturated aqueous solution; The Rhizoma Zingiberis Recens quintessence oil that takes 5g dissolves with 5ml propylene glycol, under stirring condition, slowly join in the reactor that beta-schardinger dextrin-is housed, continue heated and stirred 2h, solution decompression is concentrated into 50ml, 4 ℃ of cold preservations are spent the night, and filter out precipitation, then are placed in dry 1h at 90 ℃ of temperature, can obtain Rhizoma Zingiberis Recens quintessence oil cyclodextrin clathrate, product is white powder;
Embodiment 2
Prepare clathrate, take 2-hydroxy propyl-Beta cyclodextrin 15g and be placed in reactor, add 200ml water heated and stirred to 2-HP-BETA-CD all to dissolve, continue to be warming up to 70 ℃, make saturated aqueous solution; Take the Vanillyl butyl ether 5ml dissolve with ethanol of 5g, under stirring condition, slowly join in the reactor that 2-hydroxy propyl-Beta cyclodextrin is housed, continue heated and stirred 7h, filtered while hot goes out precipitation, be placed in again dry 1h at 90 ℃ of temperature, can obtain Vanillyl butyl ether cyclodextrin clathrate, product is white powder.
Embodiment 3
Prepare clathrate, take beta-schardinger dextrin-10g and be placed in reactor, add 200ml water heated and stirred to beta-schardinger dextrin-all to dissolve, continue to be warming up to 75 ℃, make saturated aqueous solution; Take 2g vanillin-1,2-hexanediol acetal dissolves with 5ml PEG400, under stirring condition, slowly join in the reactor that beta-schardinger dextrin-is housed, continue heated and stirred 1h, solution decompression is concentrated into 50ml, 4 ℃ of cold preservations are spent the night, filter out precipitation, be placed in dry 1h at 90 ℃ of temperature again, can obtain Rhizoma Zingiberis Recens quintessence oil cyclodextrin clathrate, product is white powder.
Embodiment 4
Prepare clathrate, take beta-schardinger dextrin-10g and be placed in reactor, add 200ml water heated and stirred to beta-schardinger dextrin-all to dissolve, continue to be warming up to 65 ℃, make saturated aqueous solution; Taking 3g vanillin-1-butanediol acetal dissolves with 5ml propylene glycol, under stirring condition, slowly join in the reactor that beta-schardinger dextrin-is housed, continue heated and stirred 1h, solution decompression is concentrated into 50ml, 4 ℃ of cold preservations are spent the night, and filter out precipitation, then are placed in dry 1h at 90 ℃ of temperature, can obtain Rhizoma Zingiberis Recens quintessence oil cyclodextrin clathrate, product is white powder.
Embodiment 5
Prepare clathrate, take beta-schardinger dextrin-10g and be placed in reactor, add 200ml water heated and stirred to beta-schardinger dextrin-all to dissolve, continue to be warming up to 70 ℃, make saturated aqueous solution; Taking 5g vanillin-1-butoxy glycerine acetal dissolves with 5ml propylene glycol, under stirring condition, slowly join in the reactor that beta-schardinger dextrin-is housed, continue heated and stirred 1.5h, solution decompression is concentrated into 50ml, 4 ℃ of cold preservations are spent the night, and filter out precipitation, then are placed in dry 1h at 90 ℃ of temperature, can obtain Rhizoma Zingiberis Recens quintessence oil cyclodextrin clathrate, product is white powder.
Embodiment 6
Warm dose of gel pack and thing, make by following method: get by mass percentage the Rhizoma Zingiberis Recens quintessence oil clathrate of 10% embodiment 1 preparation, 5% gel mechanism sodium carboxymethyl cellulose is scattered in swelling in 85% water, and mix homogeneously is made a kind of warm dose of gel pack and thing.
Embodiment 7
Warm dose of gel pack and thing, by following method, make: the Vanillyl butyl ether clathrate of getting by mass percentage 10% embodiment, 2 preparations, 5% gel-type vehicle sodium carboxymethyl cellulose is scattered in swelling in 85% water, and mix homogeneously is made a kind of warm dose of gel pack and thing.
Embodiment 8
Warm dose of gel pack and thing, make by following method: take by mass percentage 5% Vanillyl butyl ether clathrate, 2% gelled matrix hydroxypropyl emthylcellulose is scattered in swelling in 93% water, and mix homogeneously is made a kind of gel pack and thing.
Embodiment 9
Take by mass percentage the vanillyl acetal clathrate 20% of embodiment 3 preparations, the soybean phospholipid of concentration 5g/100ml and the alcoholic solution of cholesterol 80%, the mass ratio 10:1 of described soybean phospholipid and cholesterol, prepares a kind of liposome bag and thing by thin film-dispersion method.
Embodiment 10
Take by mass percentage the vanillyl acetal clathrate 10% of embodiment 4 preparations, propylene glycol: 10% ethanol 10% triclosan 0.3%, castor oil hydrogenated polyoxyethylene ether 13%, water surplus, heated and stirred is even, obtains a kind of emulsion bag and thing.
Claims (1)
1. be applied to a warm dose of clathrate of absorbent article, it is characterized in that comprising the steps preparation:
(1) prepare clathrate, take beta-schardinger dextrin-10g and be placed in reactor, add 200ml water heated and stirred to beta-schardinger dextrin-all to dissolve, continue to be warming up to 55 ℃, make saturated aqueous solution; The Rhizoma Zingiberis Recens quintessence oil that takes 5g dissolves with 5ml propylene glycol, under stirring condition, slowly join in the reactor that beta-schardinger dextrin-is housed, continue heated and stirred 2h, solution decompression is concentrated into 50ml, 4 ℃ of cold preservations are spent the night, and filter out precipitation, then are placed in dry 1h at 90 ℃ of temperature, can obtain Rhizoma Zingiberis Recens quintessence oil cyclodextrin clathrate, product is white powder;
(2) 10% get Rhizoma Zingiberis Recens quintessence oil clathrate prepared by step (1) by mass percentage, get 5% gel mechanism sodium carboxymethyl cellulose and be scattered in swelling in 85% water, mix homogeneously is made a kind of warm dose of gel pack compound.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1275403A1 (en) * | 2001-07-10 | 2003-01-15 | Lin I. Shan | Additive for a sanitary napkin and a method of adding the same |
| CN101829300A (en) * | 2010-04-13 | 2010-09-15 | 刘仁杰 | Hyperthermia agent with high thermal efficiency and multiple functions |
| CN101927031A (en) * | 2010-09-03 | 2010-12-29 | 云南清逸堂实业有限公司 | Sanitary towel heat sensitizer |
| CN101947163A (en) * | 2010-09-28 | 2011-01-19 | 山东益母妇女用品有限公司 | Warming sanitary napkin |
| CN102090950A (en) * | 2011-02-28 | 2011-06-15 | 河南省宛西制药股份有限公司 | Female sanitary article capable of relieving dysmenorrhea |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1275403A1 (en) * | 2001-07-10 | 2003-01-15 | Lin I. Shan | Additive for a sanitary napkin and a method of adding the same |
| CN101829300A (en) * | 2010-04-13 | 2010-09-15 | 刘仁杰 | Hyperthermia agent with high thermal efficiency and multiple functions |
| CN101927031A (en) * | 2010-09-03 | 2010-12-29 | 云南清逸堂实业有限公司 | Sanitary towel heat sensitizer |
| CN101947163A (en) * | 2010-09-28 | 2011-01-19 | 山东益母妇女用品有限公司 | Warming sanitary napkin |
| CN102090950A (en) * | 2011-02-28 | 2011-06-15 | 河南省宛西制药股份有限公司 | Female sanitary article capable of relieving dysmenorrhea |
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