CN102813935B - Non-woven fabrics is at the application prepared in treatment oral disease medicine and preparation - Google Patents
Non-woven fabrics is at the application prepared in treatment oral disease medicine and preparation Download PDFInfo
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- CN102813935B CN102813935B CN201210300235.3A CN201210300235A CN102813935B CN 102813935 B CN102813935 B CN 102813935B CN 201210300235 A CN201210300235 A CN 201210300235A CN 102813935 B CN102813935 B CN 102813935B
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Abstract
The invention discloses non-woven fabrics at the application prepared in treatment oral disease medicine and preparation.Made by non-woven fabrics and become small pieces, can be close to intraoral affected area for a long time, absorption cavity interior saliva, the antimicrobial factors of level in gingival sulcus fluid, hemostatic factor, when not using medicine, improve oral inflammation.Simultaneously, the small pieces that non-woven fabrics is made, be attached to the affected area of toothache, can by capillarity by the pus drain in pulp cavity out, reach the effect of pain relieving, to having an intense pain of can causing of self awareness (acute inflammation) toothache, the toothache of shake-up property (chronic inflammatory disease), pulpitis, all there is analgesic effect well.Use non-woven fabrics as pharmaceutical carrier, make medicine more fast direct ground connection can arrive focus, the utilization rate of medicine is high, can also make sustained release, reaches the object of long-time treatment.
Description
Technical field
The present invention relates to the new opplication of non-woven fabrics, the particularly application of non-woven fabrics in preparation treatment oral disease medicine, and the oral preparations prepared based on this application or medical apparatus and instruments.
Background technology
Oral cavity is an open organ, is easy to infect various disease.In oral disease, the disease relevant to tooth is the most common.
In various odontopathy, periodontal disease is the most common.According to statistics, China resident suffers from the prevalence of periodontal disease up to 80%, at middle-aged and elderly people especially up to more than 97%.The main manifestations of periodontal disease is red swelling of gingiva, hemorrhage, pyorrhea, gingival atrophy, odontoseisis, finally causes loss of tooth.Periodontal disease can bring toothache equally, has a strong impact on the daily life of patient.Meanwhile, periodontal disease can bring other complication equally, affects the health of patient.
But because oral cavity is open organ, the salivary a large amount of secretion of meeting, causes the effective ingredient of medicine to be difficult to be retained in oral cavity.And oral formulations, injection etc. need to carry out long transhipment and just can arrive focus, onset is slow, and in fact, the amount of blood supply of tooth is far fewer than other organs, and most of medicine can be fallen by metabolism, cannot play therapeutical effect.Existing medicine is invalid to the toothache caused because of pulpitis and periapical periodontitis substantially.
For alleviating the misery brought of having a toothache, present stage, most effective method was operative treatment, and as exodontia, or carry out root canal, costly, success rate is also only about 70 ~ 90%.
Non-woven fabrics is also known as adhesive-bonded fabric, be made up of orientation or random fiber, be environment-friendly materials of new generation, there is protection against the tide, ventilative, pliable and tough, light weight, not combustion-supporting, easy decomposition, nontoxic nonirritant, rich color, the feature such as to use again cheap, capable of circulation.As adopted polypropylene (PP material) pellet to be raw material more, batch continuous one-step produce through high-temperature fusion, spray webbing, paving guiding principle, hot pressing.A kind of industrialization goods of maturation.Non-woven fabrics is widely used in making agricultural film, shoemaking, process hides, mattress, child-mother-covering, decoration, chemical industry, printing, automobile, building materials, the industries such as furniture, and dress lining cloth, health care disposable surgical clothing, mask, cap, sheet, the disposable tablecloth in hotel, beauty treatment, the gift bag of Saunas and even current fashion, fine work bag, shopping bag, advertising bag etc., there are no being applied in the preparation of mouth cavity medicine or oral cavity medical apparatus.
Summary of the invention
One object of the present invention is to provide the application of non-woven fabrics in preparation treatment oral disease medical apparatus and instruments.
Another object of the present invention is the application providing non-woven fabrics as treatment oral disease pharmaceutical carrier.
Another object of the present invention is a kind of preparation for the treatment of oral disease.
The technical solution used in the present invention is:
Treat a preparation for oral disease, using non-woven fabrics as the carrier of effective ingredient.
Preferably, the thickness of preparation is 0.5 ~ 3mm.
Preferably, the effective ingredient of load on preparation is gel state, solid-state or liquid effective ingredient, and the best is gel state.Effective ingredient can be used for the treatment of medicine or the health product of oral disease for conventional Yazhoukang, fourth boron emulsifiable paste, toothache killer pill or oral rinse oral fluid etc.
Made by non-woven fabrics and become small pieces, can be close to intraoral affected area for a long time, absorption cavity interior saliva, the antimicrobial factors of level in gingival sulcus fluid, hemostatic factor, when not using medicine, improve oral inflammation.Simultaneously, the small pieces that non-woven fabrics is made, be attached to the affected area of toothache, can by capillarity by the pus drain in pulp cavity out, reach the effect of pain relieving, to having an intense pain of can causing of self awareness (acute inflammation) toothache, the toothache of shake-up property (chronic inflammatory disease), pulpitis, all there is analgesic effect well.
Use non-woven fabrics as pharmaceutical carrier, make medicine more fast direct ground connection can arrive focus, the utilization rate of medicine is high, can also make sustained release, reaches the object of long-time treatment.
Use non-woven fabrics load medicinal ingredient, be applied to oral disease afterwards, particularly the treatment of tooth relevant disease, greatly can improve the curative effect of medicine, reduce its use amount simultaneously, reduce the side effect that it brings.As fourth boron emulsifiable paste buccal bioadhesive tablet prepared by the present invention, good analgesic effect, can not cause mouth numbness simultaneously, can also greatly reduce the use amount of fourth boron emulsifiable paste.
Product of the present invention can treat the oral diseases such as gingivitis, periodontitis, pulpitis, red swelling of gingiva pyorrhea, toothache, gingival hemorrhage, oral ulcer, halitosis, hemodia effectively.
Detailed description of the invention
Treat a preparation for oral disease, using non-woven fabrics as the carrier of effective ingredient.
Preparation is thicker, and the load capacity of its medicine and absorbency are all stronger, but it is placed in oral cavity and has strong foreign body sensation, can cause the discomfort of patient.Preparation is thinner, and its comfort is naturally better, but accordingly, its load capacity and absorbency also can reduce.Preferably, the thickness of preparation is 0.5 ~ 3mm.Those skilled in the art can carry out suitable adjustment according to the load capacity of medicine and the form of medicine and the kind of oral disease.Produce as inflammation is attended by more pus, can use a little bit thicker, the preparation that absorbency is better, otherwise, then can select slightly thinner preparation.
Preferably, the effective ingredient of load on preparation is gel state, solid-state or liquid effective ingredient, and the best is gel state.
Effective ingredient can be used for the treatment of medicine or the health product of oral disease for conventional Yazhoukang, fourth boron emulsifiable paste, toothache killer pill or oral rinse oral fluid etc.
Preparation of the present invention, can by smearing effective ingredient, wrapping up, or the mode load such as infiltration is on non-woven fabrics, or use on double-deck or more layer non-woven fabrics and form.The effective ingredient of gel state, as emulsifiable paste etc. can more uniform load, also can more all even long-acting release medicinal composition in use procedure on non-woven fabrics, is preferred state.
As medicinal non-woven fabrics, especially for medical apparatus and instruments or the pharmaceutical carrier in oral cavity, the non-woven fabrics used at least should meet the requirement of product quality supervision selective examination implementation specification CCGF204.1-2008 tissue (containing wet tissue).Discharge effective ingredient in order to load better, non-woven fabrics also should have certain hygroscopicity.
Below in conjunction with experimental data, further illustrate the present invention.
Below in experiment, the non-woven fabrics of use is for pursuing progress the medical spun-laced nonwoven fabric that non-woven fabrics company limited produces in Hangzhou.
non-woven fabrics pastes the effect of having a toothache to self awareness (acute inflammation)
Experiment material: non-woven fabrics pastes, specification: 30mm × 13mm × 1mm.
Control drug: (Amoxicillin Capsules) refined come (Foshan) pharmaceutical Co. Ltd, specification: 125mg × 50, lot number: 1108714
Case is originated: self awareness (acute inflammation) patient with toothache 110 the not doing any treatment example of outpatient clinic, is divided into A and B two groups at random, is respectively 55 examples.
The diagnostic criteria that self awareness (acute inflammation) is had a toothache: local red swelling of gingiva, pyorrhea, heavier, the deep periodontal pocket 5-7mm of self awareness toothache.
Curative effect standards of grading:
Effective: medication 2-3 days, purulent discharge of pocket disappears, and conscious toothache symptom disappears completely;
Effective: medication 4-5 days abscess disappear, subjective symptoms disappears;
Invalid: symptom increases the weight of gradually, abscess is persistent, uses additive method treatment instead.
Therapeutic Method:
A group uses non-woven fabrics to paste, and gargles after meal and is affixed on affected part, keep removing for 1-2 hours, within every 8 hours, change subsides, totally three pastes for three times on the one;
B group oral amoxicillin capsule.An oral 0.5g, every 6 ~ 8 hours 1 time, a daily dose is no more than 4g.
Result: total number of cases 110 example, two kinds of therapies compare, and effective 51%, the A group obvious effective rate of effective 71%, the B group of A group is higher than B group, and P < 0.05, is listed as follows:
non-woven fabrics pastes the effect to shake-up property toothache (chronic inflammatory disease)
Experiment material: non-woven fabrics pastes, specification 30mm × 13mm × 1mm.
Control drug: metronidazole fenbufen capsule (Guangdong Taicheng Pharmaceutical Co., Ltd, specification: 175mg × 10, lot number: 20110901)
Case is originated: shake-up toothache (chronic inflammatory disease) patient 68 example not doing any treatment of outpatient clinic, being divided into A and B two groups at random, is respectively 34 examples.
The diagnostic criteria of shake-up property toothache (chronic inflammatory disease): press dental bed with hands, have tenderness, have no red and swollen pyorrhea, self awareness toothache is comparatively light, shows Chronic periodontal, gingivitis.
Curative effect standards of grading:
Effective: medication 5-7 days, dental bed is touched a tender spot and is disappeared, and subjective symptoms disappears completely;
Effective: medication is touched a tender spot and disappeared for 7-10 days, and subjective symptoms disappears;
Invalid: symptom increases the weight of gradually, touch a tender spot persistent, use additive method treatment instead.
Therapeutic Method:
A group uses non-woven fabrics to paste, and gargles after meal and is affixed on affected part, keep removing for 1-2 hours, totally three pastes for three times on the one;
B group Effect of Oral Metronidazole fenbufen capsule, every day three times, each two.
Result: total number of cases 68 example, two kinds of therapies compare, and effective 47.1%, the A group obvious effective rate of effective 61.8%, the B group of A group is higher than B group, and P < 0.05, is listed as follows:
non-woven fabrics pastes the effect to acute pulpitis
Experiment material:
Non-woven fabrics pastes, and specification 30mm × 13mm × 2mm, material is non-woven fabrics.
Control drug: (ibuprofen modified release capsule) (Sino-America Tianjin Shike Pharmaceutical Co., Ltd., specification: 300mg × 20, lot number: 12050852)
Case is originated: acute pulpitis patient 56 example not doing any treatment of outpatient clinic, is divided into A and B two groups at random, is respectively 28 examples.
The diagnostic criteria of acute pulpitis: have tooth body to damage and infect, cause spontaneous paroxysm to have a toothache, cold and hot toothache, night has a toothache, radioactivity toothache can not be located.
Curative effect standards of grading:
Effective: medication 12-24 hours, toothache disappears, and subjective symptoms disappears completely;
Effective: medication toothache in 24-48 hours is disappeared, and subjective symptoms disappears;
Invalid: symptom increases the weight of gradually, have a toothache persistent, use additive method treatment instead.
Therapeutic Method:
A group uses non-woven fabrics to paste, and gargles and is affixed on affected part, keep removing for 10 minutes, exchange cards containing all personal details and become sworn brothers and be used in conjunction three subsides during toothache, totally nine pastes for three times on the one;
B group oral ibuprofen slow releasing capsule, each one, every day twice.
Result: total number of cases 56 example, two kinds of therapies compare, and effective 57.1%, the A group obvious effective rate of effective 64.3%, the B group of A group is higher than B group, and P < 0.05, is listed as follows:
fourth boron emulsifiable paste tooth pastes the mitigation to toothache
Experiment material:
Fourth boron emulsifiable paste tooth pastes: 30mm × 13mm × 1.5mm, and specification 200mg often pastes, and patch is that intermediate loads has the two-layer nonwoven of fourth boron emulsifiable paste to form;
Control drug: fourth boron emulsifiable paste (Dandong Corning Pharmaceutical Co., Ltd, specification: 65 grams/, lot number: 20111103);
Case is originated: acute pulpitis patient 86 example not doing any treatment of outpatient clinic, is divided into A and B two groups at random, is respectively 43 examples.
The diagnostic criteria of acute pulpitis: have tooth body to damage and infect, cause spontaneous paroxysm to have a toothache, cold and hot toothache, night has a toothache, radioactivity toothache can not be located.
Curative effect standards of grading:
Effective: medication 12-24 hours, toothache disappears, and subjective symptoms disappears completely;
Effective: medication toothache in 24-48 hours is disappeared, and subjective symptoms disappears;
Invalid: symptom increases the weight of gradually, have a toothache persistent, use additive method treatment instead.
Therapeutic Method:
A group uses fourth boron emulsifiable paste tooth to paste, and gargles and be affixed on affected part during toothache, keeps removing after 1-2 hours, totally three pastes for three times on the one;
B group is coated with pudding boron emulsifiable paste in affected part, each 1 gram, is detained clear water after 5 minutes and gargles and wash away, every day 5 times.
Result: total number of cases 86 example, two kinds of therapies compare, and effective 67.4%, the A group obvious effective rate of effective 76.7%, the B group of A group is higher than B group, and P < 0.05, is listed as follows:
fourth boron emulsifiable paste tooth pastes the mitigation to oral ulcer
Experiment material:
Fourth boron emulsifiable paste tooth pastes: 30mm × 13mm × 1.5mm, and specification 200mg often pastes, and patch is that intermediate loads has the two-layer nonwoven of fourth boron emulsifiable paste to form;
Control drug: dexamethasone acetate plaster (Shenzhen Taitai Pharmaceutical Industry Co. Ltd., specification: 0.3mg × 5 slice, lot number: 11091997)
Case is originated: oral ulcer patient 62 example not doing any treatment of outpatient clinic, is divided into A and B two groups at random, is respectively 31 examples.
The diagnostic criteria of oral ulcer: send out in mucosas such as lip, cheek, soft palates, visible focal mucosa congestion and edema, the granular red point in foxtail millet, causalgia is obvious, then forms shallow table ulcer, circular or oval, diameter <5mm.
Curative effect standards of grading:
Effective: medication 24-36 hours, oral ulcer disappears, and subjective symptoms disappears completely;
Effective: medication 36-72 h oral ulcer disappears, subjective symptoms disappears;
Invalid: symptom increases the weight of gradually, oral ulcer is persistent, uses additive method treatment instead.
Therapeutic Method:
A group uses fourth boron emulsifiable paste tooth to paste, and gargles and is affixed on affected part, keeps removing after 1-2 hours, totally three pastes for three times on the one;
B group uses dexamethasone acetate plaster to be affixed on affected part, each 1, every day 3 times.
Result: total number of cases 62 example, two kinds of therapies compare, and effective 77.4%, the A group obvious effective rate of effective 74.2%, the B group of A group is suitable with B group, and P < 0.05, is listed as follows:
mica filled polypropylene tooth pastes the mitigation to gingival hemorrhage
Experiment material:
Mica filled polypropylene tooth pastes: 30mm × 13mm × 1.5mm, and specification 200mg often pastes, and patch is that intermediate loads has the two-layer nonwoven of mica filled polypropylene to form;
Control drug: mica filled polypropylene (Yunnan Paiyao Group Corp., Ltd, specification: 180 grams/, expiring date: 20141024);
Case is originated: dental pulp bleeding patients 46 example not doing any treatment of outpatient clinic, is divided into A and B two groups at random, is respectively 23 examples.
The diagnostic criteria of gingival hemorrhage: hemorrhage after gingiva feed, hemorrhage, spontaneous hemorrhage, adjoint halitosis of brushing teeth.
Curative effect standards of grading:
Effective: medication 5-7 days, gingival hemorrhage is alleviated, and eliminate halitosis, subjective symptoms disappears completely;
Effective: medication 7-15 days gingival hemorrhages improve, and halitosis alleviates, and subjective symptoms disappears;
Invalid: symptom increases the weight of gradually, gingival hemorrhage continues, and uses additive method treatment instead.
Therapeutic Method:
A group uses mica filled polypropylene tooth to paste, and gargles and is affixed on affected part, keeps removing after 1-2 hours, totally three pastes for three times on the one;
B group uses mica filled polypropylene to brush teeth, and brushes teeth 5 minutes for each 1.5 grams, every day three times morning, noon and afternoon.
Result: total number of cases 46 example, two kinds of therapies compare, and effective 43.4%, the A group obvious effective rate of effective 65.2%, the B group of A group is higher than B group, and P < 0.05, is listed as follows:
tooth doctor antiallergic sense toothpaste tooth pastes the mitigation to hemodia
Experiment material:
Tooth doctor antiallergic sense toothpaste tooth pastes: 30mm × 13mm × 1.5mm, and specification 200mg often pastes, and patch is that intermediate loads has the two-layer nonwoven of tooth doctor antiallergic sense toothpaste to form;
Control drug: tooth doctor antiallergic sense toothpaste (U.S. tooth doctor oral care implement (Hong Kong) company limited, specification: 120 grams/, expiring date: 2015020202)
Case is originated: hemodia patient 72 example not doing any treatment of outpatient clinic, is divided into A and B two groups at random, is respectively 36 examples.
The diagnostic criteria of hemodia: cold, sour food of taking food, or when brushing teeth, there is of short duration and sharp-pointed pain.
Curative effect standards of grading:
Effective: medication 5-7 days, hemodia is alleviated, and subjective symptoms disappears completely;
Effective: medication 7-15 days hemodias improve, and subjective symptoms disappears;
Invalid: symptom increases the weight of gradually, hemodia continues, and uses additive method treatment instead.
Therapeutic Method:
A group uses tooth doctor antiallergic sense toothpaste tooth to paste, and gargles and is affixed on affected part, keep removing after 1-2 hours, totally three paste for three times on the one;
B group uses tooth doctor antiallergic sense toothpaste to brush teeth, and brushes teeth 5 minutes for each 1.5 grams, every day three times morning, noon and afternoon.
Result: total number of cases 72 example, two kinds of therapies compare, and effective 63.9%, the A group obvious effective rate of effective 77.8%, the B group of A group is higher than B group, and P < 0.05, is listed as follows:
Visible, by medicinal ingredient load on non-woven fabrics, the oral diseases such as gingivitis, periodontitis, pulpitis, red swelling of gingiva pyorrhea, toothache, gingival hemorrhage, oral ulcer, halitosis, hemodia can be treated more cost-effectively.
Claims (4)
1. non-woven fabrics is directly affixed on the application in oral cavity troubles punishment treatment oral disease medical apparatus and instruments in preparation.
2. be directly affixed on the preparation that oral disease is treated in oral cavity troubles punishment, it is characterized in that: described preparation is using non-woven fabrics as the carrier of effective ingredient, and the effective ingredient of described preparation is Yazhoukang, fourth boron emulsifiable paste, toothache killer pill or oral rinse oral fluid.
3. preparation according to claim 2, is characterized in that: the thickness of described preparation is 0.5 ~ 3mm.
4. the preparation according to Claims 2 or 3, is characterized in that: the effective ingredient of described preparation is gel state, solid-state or liquid effective ingredient.
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| CN201210300235.3A CN102813935B (en) | 2012-03-29 | 2012-08-22 | Non-woven fabrics is at the application prepared in treatment oral disease medicine and preparation |
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| CN2012100986384 | 2012-03-29 | ||
| CN201210098638.4 | 2012-03-29 | ||
| CN201210098638 | 2012-03-29 | ||
| CN201210300235.3A CN102813935B (en) | 2012-03-29 | 2012-08-22 | Non-woven fabrics is at the application prepared in treatment oral disease medicine and preparation |
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| CN102813935A CN102813935A (en) | 2012-12-12 |
| CN102813935B true CN102813935B (en) | 2016-04-20 |
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| CN106267166A (en) * | 2016-09-29 | 2017-01-04 | 南京医科大学附属口腔医院 | A kind of dental pulp regeneration paste and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101023995A (en) * | 2006-02-24 | 2007-08-29 | 张琦慧 | Novel plaster for treating stamotocace |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101023995A (en) * | 2006-02-24 | 2007-08-29 | 张琦慧 | Novel plaster for treating stamotocace |
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