CN102813896B - Preparation method of traditional Chinese medicine for treating cold sensitivity-type acute glomerulonephritis - Google Patents

Abstract

The invention discloses a preparation method of a traditional Chinese medicine for treating cold sensitivity-type acute glomerulonephritis and belongs to the technical field of traditional Chinese medicine preparation. Amoxicillin used for treating cold sensitivity-type acute glomerulonephritis at present can cause rash and a large amount of amoxicillin also can cause nausea, epigastric discomfort and diarrhea after being orally taken. The preparation method comprises the following steps of immersing 26 traditional Chinese medicines of semen hyoscyami, mongollian thyme herb, pepper, long pepper, mountain spicy fruit, fennel, Chinese chives, lesser galangal rhizome, common cnidium fruit, hot pepper, caraway, rhizoma kaempferiae, common monkshood mother root, radix aconiti lateralis preparata, sabia japonica, kadsura pepper stem, Chinese starjasmine stem, dutchmanspipe vine, Geranium wilfordii Maxim., peach kernel, safflower, red sage root, moutan bark, twig and leaf of silvervine actinidia, dried ginger and liquorice root in water, and carrying out decoction by a slow fire to obtain a decoction, wherein the decoction is the traditional Chinese medicine for treating cold sensitivity-type acute glomerulonephritis. The traditional Chinese medicine for treating cold sensitivity-type acute glomerulonephritis has small side effects and a high cure rate, and realizes just right utilization of the monarch drugs, the minister drugs, the assistant drugs and the guide drugs. The traditional Chinese medicine for treating cold sensitivity-type acute glomerulonephritis utilizes traditional Chinese medicines as raw materials, and prevents adverse reactions and anaphylactic reactions caused by western medicines.

Description

A kind of Chinese medicinal preparation method for the treatment of cold responsive type acute glomerulonephritis

Technical field

The present invention relates to the Chinese medicinal preparation method technical field, more specifically a kind of Chinese medicinal preparation method for the treatment of cold responsive type acute glomerulonephritis.

Background technology

The current cold responsive type acute glomerulonephritis for the treatment of, the general employing: 1, amoxicillin: accidental erythra, oral can have nauseating, epigastric discomfort, diarrhoea etc. after a large amount of; Pseudomembranous colitis.2, penicillin: allergy easily occurs in this product, anaphylactic shock (the most dangerous anaphylactic shock particularly, can occur in and do tuerculoderma at that time, only a few can occur in the continuous use process, Delayed Hypersensitivity shock), as rescued not in time, can critical life, therefore all will improve protection before, during and after medication, so as to avoid an accident.Attention: before application, must ask and have or not clearly anaphylactic disease, with having or not the allergy such as erythra, heating to occur after penicillin, must first do penicillin skin test.3, hydrochlorothiazide: the low blood chlorine of 1. hypokalemia, and normal companion, hypomagnesemia, hypokalemia can bring out hepatic coma and Folium Digitalis Purpureae institute proarrhythmia, needs timely kalium replenishment or add to stay the potassium diuretic; 2. hyperglycemia reduces carbohydrate tolerance; 3. hyperuricemia, can bring out or increase the weight of symptom to the goat image; 4. azotemia, because reducing glomerular filtration rate, increase the weight of azotemia and renal function further worsened the renal insufficiency patient, and this product diuretic effect is poor, therefore the renal failure patient is cautious use of or forbids; 5. ammonirrhea reduces, and may the H+ secretion be reduced because suppressing carbonic anhydrase, and the ammonia secretion also reduces.During hepatic disfunction, can bring out hepatic coma; 6. parathyroid gland effect: long-term taking can cause hypercalcemia, low serum p disease and parathyroid hyperplasia; 7. other: skin erythema, photoallergic dermatitis, pancreatitis, intrahepatic cholestasis, bone marrow depression, especially thrombocytopenia can cause the announcements that all appear in the newspapers such as purpura, neutrophilic granulocyte minimizing, hemolytic anemia of newborn, the serum antinuclear antibody positive.4, reserpine: nasal obstruction, gastric acid secretion increase, times of defecation increases and aroused in interest slack-off etc., even long-term extensive application can occur that apathetic expression, drowsiness, spirit depressing cause extrapyramidal symptoms, the performance muscular tremor.1. to activeness Peptic Ulcers and dysthymia person's forbidding; 2. reserpine can enter fetal tissue by Placenta Hominis, if the antenatal application of anemia of pregnant woman can cause neonate nasal obstruction, respiratory tract obstruction, should need not as far as possible.5, carbenicillin: various types of allergy can occur.May cause neural poison reaction, pulmonary edema after heavy dose of administration, may occur during medication that the transience transaminase raises and granulocytopenia.6, captopril: important side effect is Toxicity of Kidney and granulocytopenia, is secondly erythra, dysgeusia and cough.Heavy dose can cause hemodynamic change, symptomatic hypotension etc.

Summary of the invention

For overcoming above-mentioned shortcoming, the objective of the invention is to invent a kind of Chinese medicinal preparation method for the treatment of cold responsive type acute glomerulonephritis.Acute glomerulonephritis, be called for short acute nephritis, is one group of common glomerule illness.Onset is anxious, and take hematuria, oliguria, albuminuria, edema and hypertension etc. is its Clinical symptoms.Acute nephritis can be because of due to Different types of etiopathogenises, and wherein modal is post-streptococcal infection nephritis, and other causes of disease still have antibacterial (as staphylococcus), virus (as hepatitis B virus), protozoon (as plasmodium) etc.Primary disease belongs to " edema due to wind pathogen ", the category of " YANG edema " and " hematuria " in Chinese medicine " edema ".

etiology and pathogenesis:it is main clinical manifestation that acute glomerulonephritis be take hematuria, edema,proteinuria,hypertension.Human liquid's metabolism, rely on the logical of lung qi to adjust, the transferring of temper, and opening of kidney qi is entire, thereby makes three warmers bring into play the duty that it is certainly shown disrespect on.Ailment said due to cold or exposure, water are wet in order to experience for the primary disease cause of disease, noxious dampness, damp and hot heresy, invasion and attack flesh table, and internal injury is in lung, impairment of dispersing and descending function of the lung; Or in be attributed to spleen, spleen loses transporting; Under injure kidney, kidney loses folding, disturbance in water passage, and be edema.In the acute nephritis edema stage, inhibited pulmonary QI, at lung, spleen, be take as main in the main diseases position.If hematuria is obvious, how by the damp-heat accumulation bladder, injury of blood collaterals by heat, due to venation is impaired.If the intenseness of heat wind symptom, disturb sun clearly on wind-fire, the evil card of violating conscience such as convulsions, coma dizziness headache appears, even.Spleen-QI failing to rise up, deficiency of kidney-QI, essence is closed not solid, and albuminuria, appear in the separating clear and excreting turbid dereliction of duty.Therefore the sick position of primary disease is dirty at lung, spleen, kidney three, syndrome develop be from table and, by the part of the body cavity above the diaphragm housing the heart and lungs, in Jiao and reach the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, from real, to simulataneous insufficiency and excessive, develop.Due to too responsive to cold, " obtain Wen Zehang, meet cold solidifying ", QI-blood circulation is not smooth, and sends out primary disease.

clinical manifestation:suffer the heresy of cold with the passing of time, cold and bring out primary disease whenever.Onset is more anxious, and state of an illness weight does not wait.Most of patients has clear and definite streptococcal infection history, as upper respiratory tract infection, pharyngitis, tonsillitis and skin infection etc.Sudden onset, onset symptoms mostly is edema and hematuria.1, edema: the lighter only plays blepharoedema morning, and complexion is paler, is " nephritis face ".Severe one is prolonged and whole body, and finger pressure skin can be without significant depressions, and body weight also increases thereupon.2, hypertension: see 80% case, mostly be light moderate hypertension, diastolic pressure is less than 14kpa.The hypertension of acute nephritis mostly is a property crossed, and the generation reason is mainly water, sodium retention makes due to the blood volume expansion.3, urine is abnormal: 1. oliguria: the most of patients onset has oliguria often, as every day the urine amount be less than 500ml person, slight azotemia can appear.2. hematuria: see all acute nephritis patients, can be gross hematuria, or muddy coffee-like, general persistence is not long, transfers microscopic hematuria to.3. albuminuria: most of patients all has 4. whole body performance of albuminuria in various degree: tired, lumbago, anorexia, feel sick, vomiting, the person of being in a bad way can have headache, dizziness, drowsiness, blurred vision etc.Pale tongue, tongue is white, slow pulse.

its technical scheme is:get Semen Hyoscyami 9 weight portions, Herba Thymi 1 weight portion, Fructus Piperis 6 weight portions, Fructus Piperis Longi 9 weight portions, Fructus Litseae 12 weight portions, Fructus Foeniculi 12 weight portions, Folium Allii tuberosi 12 weight portions, Rhizoma Alpiniae Officinarum 6 weight portions, Fructus Cnidii 9 weight portions, Fructus Capsici 6 weight portions, Fructus cari carvi 9 weight portions, Rhizoma Kaempferiae 6 weight portions, Radix Aconiti 6 weight portions, Radix Aconiti 6 weight portions, Caulis Sinomenii 6 weight portions, Caulis Piperis Kadsurae 12 weight portions, Caulis Trachelospermi 6 weight portions, Herba Aristolochiae 9 weight portions, Herba Erodii (Herba Geranii) 6 weight portions, Semen Persicae 12 weight portions, Flos Carthami 6 weight portions, Radix Salviae Miltiorrhizae 12 weight portions, Cortex Moutan 12 weight portions, Ramulus et Folium Actinidiae Polygamae 6 weight portions, Rhizoma Zingiberis 9 weight portions and Radix Glycyrrhizae 9 weight portions, above 26 flavor Chinese medicines are put into to 1800 ml waters, soak 35 minutes, then slow fire is fried 30 minutes, boil medicine altogether 390 milliliters of liquid of filter and remove residue, fried medicinal liquid is the Chinese medicine of the cold responsive type acute glomerulonephritis for the treatment of.

the advantage of this invention is:we's 26 flavor Chinese medicines, all can buy in pharmacy, makes simply, and the herb liquid toxic and side effects of making is little, short treating period, and cure rate is high.Monarch, just right.In the time of application Chinese medicine, untoward reaction, anaphylaxis and the toxic reaction of having avoided Western medicine to cause.Semen Hyoscyami, Herba Thymi, Fructus Piperis, Fructus Piperis Longi, Fructus Litseae, Fructus Foeniculi, Folium Allii tuberosi, Rhizoma Alpiniae Officinarum, Fructus Cnidii, Fructus Capsici, Fructus cari carvi, Rhizoma Kaempferiae, Radix Aconiti, the above 14 flavor medical instruments of Radix Aconiti dispel the wind by numbness, subduing swelling and detoxicating, relieving the exterior syndrome with drugs of pungent in flavor and warm in nature, dispersing cold for relieving pain, Xin Xiang is sensible, the effect of expelling cold to relieve vomiting, promoting the flow of QI-blood by warming the meridian, promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion, warming the kidney to activate YANG.In the process of the cold responsive type acute glomerulonephritis for the treatment of, play the primary treatment effect, therefore be monarch drug.Caulis Sinomenii, Caulis Piperis Kadsurae, Caulis Trachelospermi, Herba Aristolochiae, Herba Erodii (Herba Geranii), Semen Persicae, Flos Carthami, Radix Salviae Miltiorrhizae, Cortex Moutan, above 9 flavor medical instruments have the effect of the wind prevailing over dampness of searching, arthralgia relieving by relaxing muscles and tendons, wind-damp dispelling, the meridian dredging, removing blood stasis with potent drugs promoting the circulation of blood, stasis-dispelling and pain-killing.In the process of the cold responsive type acute glomerulonephritis for the treatment of, can assist principal agent performance therapeutical effect, therefore be ministerial drug.Ramulus et Folium Actinidiae Polygamae: suffering, temperature, slightly poisonous.Enter liver, kidney two warps.Hard masses softening and resolving, the cold tonify deficiency of temperature, wind expelling stagnation removing.Rhizoma Zingiberis: hot, hot.Enter spleen, stomach, lung three warps.Warming middle-JIAO is by cold, and recuperating depleted YANG is promoted blood circulation, the expectorant therapeutic method to keep the adverse QI flowing downwards, warming the lung to resolve fluid-retention, warming the meridian for stopping bleeding, control carbuncle from the beginning of.The through focus of all medicines of above 2 flavor medicine energy rate, therefore be adjuvant drug.Radix Glycyrrhizae: sweet, flat.Enter 12 warps.The spleen reinforcing lung moistening, Yiqi and vein recovery, relieving spasm to stop pain, heat-clearing and toxic substances removing, the mediation property of medicine.Can entangle the bias of all medicines, can alleviate again the toxicity of all medicines, therefore for making medicine.Semen Hyoscyami, Herba Thymi, Fructus Piperis, Fructus Piperis Longi, Fructus Litseae, Fructus Foeniculi, Folium Allii tuberosi, Rhizoma Alpiniae Officinarum, Fructus Cnidii, Fructus Capsici, Fructus cari carvi, Rhizoma Kaempferiae, Radix Aconiti, Caulis Sinomenii, Caulis Piperis Kadsurae, Caulis Trachelospermi, Herba Aristolochiae, Herba Erodii (Herba Geranii), Semen Persicae, Flos Carthami, Radix Salviae Miltiorrhizae, Cortex Moutan, Ramulus et Folium Actinidiae Polygamae, Rhizoma Zingiberis, Radix Glycyrrhizae, above 26 flavor medical instruments dispel the wind by numbness, subduing swelling and detoxicating, relieving the exterior syndrome with drugs of pungent in flavor and warm in nature, dispersing cold for relieving pain, expelling cold to relieve vomiting, promoting the flow of QI-blood by warming the meridian, promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion, the effect that wind prevailing over dampness, arthralgia relieving by relaxing muscles and tendons, wind-damp dispelling were enriched blood, searched to warming the kidney to activate YANG, loose blood.Monarch, compatibility is proper, is the optimum formula of the cold responsive type acute glomerulonephritis for the treatment of.Semen Hyoscyami: bitter, hot, temperature, poisonous.The spasmolytic sedate, promoting the circulation of QI to relieve pain, expelling cold and freeing bi, dampness removing to stop itchin.Herba Thymi: hot, warm, poisonous.Enter lung, spleen two warps.Warming spleen and stomach for dispelling cold, wind-expelling pain-stopping.Fructus Piperis: suffering, heat.Enter stomach, large intestine channel.Warming the middle warmer and descending qi, the treatment puerperal abdonimal pain, the toothache for the treatment of superficial heat, the treatment tumbling down swells and ache, and separates bromatotoxin.Fructus Piperis Longi: suffering, heat.Enter spleen, stomach, large intestine channel.Warming spleen and stomach for dispelling cold, promoting the circulation of QI to relieve pain.Fructus Litseae: hot, bitter, temperature.Enter spleen, stomach, kidney, urinary bladder channel.Warming spleen and stomach for dispelling cold, promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion, warming the kidney to activate YANG.Fructus Foeniculi: hot, bitter, temperature.Enter liver,kidney,spleen, stomach warp.Dispersing cold for relieving pain, the kidney warming reducing urination, regulating qi-flowing for harmonizing stomach, the damp eliminating profit is turbid.Folium Allii tuberosi: suffering, temperature.Enter liver, stomach, kidney channel.Warming middle-JIAO to promote flow of QI, loose blood is enriched blood, subduing swelling and detoxicating.Rhizoma Alpiniae Officinarum: suffering, temperature.Enter spleen, stomach warp.Warming spleen and stomach for dispelling cold, the logical pain relieving of temperature, stomach function regulating is flat contrary, the circulation of qi promoting intestinal stasis relieving.Fructus Cnidii: hot, bitter, temperature, nontoxic.Enter kidney, spleen channel.Warming the kidney to invigorate YANG, expelling cold and dampness.Fructus Capsici: suffering, heat.Enter the heart, spleen channel.Warming spleen and stomach for dispelling cold, treatment chilblain, digesting and appetizing.Fructus cari carvi: sweet, micro-suffering, temperature.Enter kidney, spleen, stomach warp.Warming middle-JIAO and strengthening the spleen, the wind dispelling cold relieving.Rhizoma Kaempferiae: suffering, temperature.Spleen, stomach.Warming middle-JIAO helps digestion, wind-expelling pain-stopping, and removing blood stasis to reduce swelling, ward off immoral conduct gas.Radix Aconiti: hot, hot, poisonous.Enter the heart, liver,kidney,spleen warp.Expelling wind and removing dampness, antalgic.Radix Aconiti: suffering, heat, poisonous.Enter spleen, kidney channel.Expelling wind and cold.Benefiting the fire of the gate of life to invigorate YANG, adjust the blood repercussive, kidney-tonifying health-care.Caulis Sinomenii: hot, bitter, temperature.Enter liver, spleen channel.Search wind prevailing over dampness, arthralgia relieving by relaxing muscles and tendons.Caulis Piperis Kadsurae: hot, bitter, tepor.Enter liver, spleen channel.Wind-damp dispelling, the meridian dredging.Caulis Trachelospermi: hardship is slightly cold.Enter the heart, Liver Channel.Dispelling wind and removing obstruction in the collateral, the removing heat from blood detumescence.Herba Aristolochiae: suffering, temperature.Enter the heart, lung, spleen, kidney channel.The removing dampness of dispeling the wind, the capable water of promoting the circulation of QI and blood.Herba Erodii (Herba Geranii): hardship, micro-suffering, flat.Enter liver, kidney channel.Expelling wind and removing dampness, dredge the meridian passage.Semen Persicae: bitter, sweet, flat.Enter the heart, liver, large intestine channel.The removing blood stasis with potent drugs promoting the circulation of blood, moisturize laxation.Flos Carthami: suffering, temperature.Enter the heart, Liver Channel.Promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing.Radix Salviae Miltiorrhizae: hardship is slightly cold.Enter the heart, Liver Channel.Blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, relieving restlessness is calmed the nerves.Cortex Moutan: bitter, hot, be slightly cold.Enter the heart, liver, kidney channel.Clearing away heat and cooling blood, removing heat from the liver to lower the high blood pressure, activating blood circulation and dissipating blood stasis.Ramulus et Folium Actinidiae Polygamae: suffering, temperature, slightly poisonous.Enter liver, kidney two warps.Hard masses softening and resolving, the cold tonify deficiency of temperature, wind expelling stagnation removing.Rhizoma Zingiberis: hot, hot.Enter spleen, stomach, lung three warps.Warming middle-JIAO is by cold, and recuperating depleted YANG is promoted blood circulation, the expectorant therapeutic method to keep the adverse QI flowing downwards, warming the lung to resolve fluid-retention, warming the meridian for stopping bleeding, control carbuncle from the beginning of.Radix Glycyrrhizae: sweet, flat.Enter 12 warps.The spleen reinforcing lung moistening, Yiqi and vein recovery, relieving spasm to stop pain, heat-clearing and toxic substances removing, the mediation property of medicine.

The specific embodiment

Get Semen Hyoscyami 9g, Herba Thymi 1g, Fructus Piperis 6g, Fructus Piperis Longi 9g, Fructus Litseae 12g, Fructus Foeniculi 12g, Folium Allii tuberosi 12g, Rhizoma Alpiniae Officinarum 6g, Fructus Cnidii 9g, Fructus Capsici 6g, Fructus cari carvi 9g, Rhizoma Kaempferiae 6g, Radix Aconiti 6g, Radix Aconiti 6g, Caulis Sinomenii 6g, Caulis Piperis Kadsurae 12g, Caulis Trachelospermi 6g, Herba Aristolochiae 9g, Herba Erodii (Herba Geranii) 6g, Semen Persicae 12g, Flos Carthami 6g, Radix Salviae Miltiorrhizae 12g, Cortex Moutan 12g, Ramulus et Folium Actinidiae Polygamae 6g, Rhizoma Zingiberis 9g and Radix Glycyrrhizae 9g, above 26 flavor medicines are put into 1800 ml waters together, soak 35 minutes, then slow fire is fried 30 minutes, filter and remove residue, fried medicinal liquid is the Chinese medicine of the cold responsive type acute glomerulonephritis for the treatment of.Boil medicine altogether 390 milliliters of liquid, when the client need treatment of cold responsive type acute glomerulonephritis, making fluid temperature is 36 ℃, each 130 milliliters, oral, every day three times, within 2nd, be a course for the treatment of, if symptom is still deposited, then took for second course for the treatment of, so that recovery from illness.

In 376 routine cold responsive type acute glomerulonephritis patients, male's 215 examples, account for 57.18%; Women's 161 examples, account for 42.82%.The male is more than the women.

The range of age of table one, 376 routine cold responsive type acute glomerulonephritis patients

Age (year)	18～20	21～30	31～50	51～55
					Number of cases	5	276	92	3
Percentage ratio	1.33%	73.4%	24.47%	0.8%

Table two, 376 routine cold responsive type acute glomerulonephritis patient curative effect tables

Curative effect	Cure	Take a turn for the better	Invalid
				Number of cases	371	5	Nothing
Percentage ratio	98.67%	1.33%	Nothing

Table three, 376 routine cold responsive type acute glomerulonephritis patients show the course for the treatment of

The treatment natural law	3～5	6～9	10～15	16～21
					Number of cases	8	274	89	5
Percentage ratio	2.13%	72.87%	23.67%	1.33%

Information slip before and after table four, 376 routine cold responsive type acute glomerulonephritis patient treatments

Claims (1)

1. a Chinese medicinal preparation method for the treatment of cold responsive type acute glomerulonephritis, it is characterized in that: get Semen Hyoscyami 9 grams, Herba Thymi 1 gram, Fructus Piperis 6 grams, Fructus Piperis Longi 9 grams, Fructus Litseae 12 grams, Fructus Foeniculi 12 grams, Folium Allii tuberosi 12 grams, Rhizoma Alpiniae Officinarum 6 grams, Fructus Cnidii 9 grams, Fructus Capsici 6 grams, Fructus cari carvi 9 grams, Rhizoma Kaempferiae 6 grams, Radix Aconiti 6 grams, Radix Aconiti 6 grams, Caulis Sinomenii 6 grams, Caulis Piperis Kadsurae 12 grams, Caulis Trachelospermi 6 grams, Herba Aristolochiae 9 grams, Herba Erodii 6 grams, Semen Persicae 12 grams, Flos Carthami 6 grams, Radix Salviae Miltiorrhizae 12 grams, Cortex Moutan 12 grams, Ramulus et Folium Actinidiae Polygamae 6 grams, Rhizoma Zingiberis 9 grams and Radix Glycyrrhizae 9 grams, above 26 flavor Chinese medicines are put into to 1800 ml waters, soak 35 minutes, then slow fire is fried 30 minutes, boil medicine altogether 390 milliliters of liquid of filter and remove residue, fried medicinal liquid is the Chinese medicine of the cold responsive type acute glomerulonephritis for the treatment of.

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