CN102813764B - Chinese herbal medicinal composition used for reducing blood viscosity and blood lipid and preparation method thereof - Google Patents
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Abstract
The invention discloses a Chinese herbal medicinal composition used for reducing blood viscosity and blood lipid. The Chinese herbal medicinal composition used for reducing blood viscosity and blood lipid mainly comprises the following raw materials in parts by weight: 10-60 parts of milk vetch, 5-30 parts of szechuan lovage rhizome, 3-18 parts of earthworm, 1.5-9 parts of leech, 10-30 parts of rhizome alismatis, 10-30 parts of hawthorn, 10-35 parts of salviae miltiorrhizae, 15-30 parts of herba siegesbeckiae, 10-30 parts of semen cassiae, 5-30 parts of seaweed and 5-30 parts of liquorice. Clinical results and experiments show that the Chinese herbal medicinal composition disclosed by the invention has the effects of tonifying qi, strengthening the body resistance, invigorating blood circulation to dredge vessels, reducing phlegm and discharging dirt, hemorheology of middle-aged patients can be improved, blood lipid can be regulated, occurrence and development of atherosclerosis can be prevented and delayed, blood supply and oxygen supply of important organs such as the heart and the brain can be improved, and the Chinese herbal medicinal composition disclosed by the invention is mainly used for treating hyperviscosity and hyperlipoidemia and can be used for preventing apoplexy diseases and heart diseases such as cerebral infarction, angina, cerebral ischemia, ischemia apoplexy and myocardial infarction.
Description
Technical field
The invention belongs to the field of Chinese medicines, more specifically, the present invention relates to a kind of Chinese medicine composition that reduces blood viscosity and blood fat and preparation method thereof.
Background technology
Along with the raising day by day of living standards of the people, that people pursue is higher fatty acid, the diet of high protein, hypokinesia, cause high blood viscosity and hyperlipidemia patient more and more, and blood viscosity to increase with Lipid increase be the important risk factor of cardiovascular and cerebrovascular disease morbidity, the clinical manifestation of high blood viscosity and hyperlipemia is fatigue and weakness, dizzy giddy, discomfort uncomfortable in chest, tinnitus limb fiber crops, body of the tongue lining is purple, greasy fur on tongue, Hemorheology shows as whole blood viscosity (height is cut, low cutting) and increases, and plasma viscosity raises, and platelet aggregation rate raises.In existing document, there is report to utilize prescriptions of Chinese medicine to treat high blood viscosity and hyperlipemia, have following defect: (1), based on patient's determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs prescription, does not catch basic pathogenesis, and effectiveness has to be tested; (2) deficiency course for the treatment of of intervening, is difficult to evaluate real curative effect, easily bounce-back after drug withdrawal; (3) safety of long-term taking does not have systematic science assessment.
Summary of the invention
Based on this, the invention provides a kind of new reduction blood viscosity and the Chinese medicine composition of blood fat.
Reduce a Chinese medicine composition for blood viscosity and blood fat, this Chinese medicine composition is mainly made up of the crude drug of following weight: Radix Astragali 10-60 part, Rhizoma Chuanxiong 5-30 part, Pheretima 3-18 part, Hirudo 1.5-9 part, Rhizoma Alismatis 10-30 part, Fructus Crataegi 10-30 part, Radix Salviae Miltiorrhizae 10-35 Fen, Herba Siegesbeckiae 15-30 part, Semen Cassiae 10-30 part, Sargassum 5-30 part, Radix Glycyrrhizae 5-30 part.Wherein the Radix Astragali is Radix Astragali or Radix Astragali Preparata.
In an embodiment, described Chinese medicine composition is mainly made up of the crude drug of following weight therein: 30 parts of the Radixs Astragali, 6 parts of Rhizoma Chuanxiongs, 6 parts of Pheretimas, 1.5 parts of Hirudos, 15 parts of Rhizoma Alismatis, 15 parts of Fructus Crataegis, Radix Salviae Miltiorrhizae 30 15 parts of Fen, Herba Siegesbeckiaes, 15 parts of Semen Cassiaes, 10 parts of Sargassums, 6 parts, Radix Glycyrrhizae.
In an embodiment, described Chinese medicine composition is mainly made up of the crude drug of following weight therein: 60 parts of the Radixs Astragali, 15 parts of Rhizoma Chuanxiongs, 12 parts of Pheretimas, 3 parts of Hirudos, 30 parts of Rhizoma Alismatis, 30 parts of Fructus Crataegis, Radix Salviae Miltiorrhizae 15 30 parts of Fen, Herba Siegesbeckiaes, 30 parts of Semen Cassiaes, 25 parts of Sargassums, 10 parts, Radix Glycyrrhizae.
In some embodiment, described Chinese medicine composition is pill, tablet, powder, capsule or granule therein.
The present invention also provides the preparation method of the Chinese medicine composition of above-mentioned reduction blood viscosity and blood fat, comprises the following steps:
(1) except Hirudo, by other 10 kinds of crude drug choppings, mix, decoct with water, filter, obtain medicinal liquid;
(2) negative pressure concentrated medicament, medicine liquid volume reduces to original 20-30%;
(3) by Hirudo levigation, join in the medicinal liquid in step (2), fully mix, obtain described Chinese medicine composition.
In some embodiment, in described step (1), add crude drug weight 40-60 water doubly therein, decoct 3-4 time, each 1.5-2.5 hour.
In some embodiment, in described step (2), negative pressure is concentrated, and medicine liquid volume is reduced to original 25% therein.
In some embodiment, get Chinese medicine composition therein, add conventional adjuvant, make tablet, pill, powder, capsule or granule.
Prescriptions of Chinese medicine 1-6 (the document 1: Hao Chuanzheng of the treated high blood viscosity of reporting in Chinese medicine composition of the present invention and existing document and hyperlipemia, Zhu Jianhua etc. two the loose impact [J] on high sticky blood rat falls. Chinese TCM basis medical journal, 2001, 7 (6): 25-26. document 2: Zhu Jianhua, Zhu Jianping. the Clinical and experimental study [J] of proved recipe " two fall loose " to hyperlipemia. Chinese Medicine journal, 2000, 15 (5): 33-35. document 3: Hao Chuanzheng, Gu Haiying. the two anticoagulation effect in vitros that fall apart that fall of proved recipe are inquired into [J]. Chinese Chinese medicine information magazine, 2000, 7 (4): 48-48. document 4: Zhu Jianhua, Hao Chuanzheng. the two clinical researches [J] of falling loose treatment high blood viscosity of proved recipe. Chinese TCM basis medical journal, 1999, 5 (11): 38-41. document 5: Hao Chuanzheng, Zhu Jianhua. " two fall loose " impact [J] on Experimental Hyperlipoidemia Rabbits. the Jiangsu traditional Chinese medical science, 1998, 19 (2): 45-45. document 6: Zhu Jianhua. insect medicine application performance [J]. Chinese Medicine journal, 1993, 8 (1): 46-48) each component is listed in table 1, wherein the prescriptions of Chinese medicine in existing document is not all reported dosage and concrete preparation method.
The Component comparison of the prescriptions of Chinese medicine of table 1 Chinese medicine composition of the present invention and bibliographical information
Chinese medicine composition of the present invention is all different from the prescriptions of Chinese medicine in document 1-6, and in existing document and dosage of unexposed prescriptions of Chinese medicine and preparation method thereof, according to theory of Chinese medical science, prescription is different, and its effect and main disease to be treated all have very big difference.Chinese medicine composition of the present invention is through clinical and experimental results show that, there is QI invigorating righting, blood circulation and channel invigorating, reduces phlegm and lets out the effects such as turbid, can improve hemorheology, the adjusting blood fat of middle-older patient, prevention and delay atherosclerotic generation, development, improve the blood supply oxygen supply of the vitals such as the heart, brain, be mainly used in treating high blood viscosity and hyperlipemia, can be used for prevention of stroke disease and heart disease, as cerebral infarction, angina pectoris, cerebral ischemia, Ischemic Apoplexy, angina pectoris, myocardial infarction etc.
Detailed description of the invention
Describe the present invention in detail by specific embodiment below.
1 one kinds of embodiment reduce the Chinese medicine composition (granule) of blood viscosity and blood fat
Reduce a Chinese medicine composition for blood viscosity and blood fat, this Chinese medicine composition is made up of the crude drug of following weight: Radix Astragali 30g, Rhizoma Chuanxiong 6g, Pheretima 6g, Hirudo 1.5g, Rhizoma Alismatis 15g, Fructus Crataegi 15g, Radix Salviae Miltiorrhizae 30g, Herba Siegesbeckiae 15g, Semen Cassiae 15g, Sargassum 10g, Radix Glycyrrhizae 6g.
The Chinese medicine composition of embodiment 1 makes by following preparation method:
(1) Radix Astragali, Rhizoma Chuanxiong, Pheretima, Rhizoma Alismatis, Fructus Crataegi, Radix Salviae Miltiorrhizae, Herba Siegesbeckiae, Semen Cassiae, Sargassum, Radix Glycyrrhizae are taken by weight, chopping, mixes;
(2) add the drinking water of 50 times, decoct 120 minutes;
(3) filter, obtain medicinal liquid;
(4) decoct again 2 times according to the method for (2), the medicinal liquid of three decoctions is mixed;
(5) negative pressure concentrated medicament, medicine liquid volume reduces to original 25%;
(6) add appropriate dextrin, spray, granulate, cross 100 mesh sieves;
(7) add the Hirudo of levigation, fully mix;
(8) sterilizing, packaging, to obtain final product.
2 one kinds of embodiment reduce the Chinese medicine composition (granule) of blood viscosity and blood fat
Reduce a Chinese medicine composition for blood viscosity and blood fat, this Chinese medicine composition is made up of the crude drug of following weight: Radix Astragali 60g, Rhizoma Chuanxiong 15g, Pheretima 12g, Hirudo 3g, Rhizoma Alismatis 30g, Fructus Crataegi 30g, Radix Salviae Miltiorrhizae 15g, Herba Siegesbeckiae 30g, Semen Cassiae 30g, Sargassum 25g, Radix Glycyrrhizae 10g.Preparation method is with embodiment 1.
3 one kinds of embodiment reduce the Chinese medicine composition (tablet) of blood viscosity and blood fat
Reduce a Chinese medicine composition for blood viscosity and blood fat, this Chinese medicine composition is mainly made up of the crude drug of following weight: Radix Astragali 10g, Rhizoma Chuanxiong 25g, Pheretima 15g, Hirudo 8g, Rhizoma Alismatis 20g, Fructus Crataegi 20g, Radix Salviae Miltiorrhizae 25g, Herba Siegesbeckiae 20g, Semen Cassiae 20g, Sargassum 5g, Radix Glycyrrhizae 25g.
The Chinese medicine composition of embodiment 3 makes by following preparation method:
(1) Radix Astragali, Rhizoma Chuanxiong, Pheretima, Rhizoma Alismatis, Fructus Crataegi, Radix Salviae Miltiorrhizae, Herba Siegesbeckiae, Semen Cassiae, Sargassum, Radix Glycyrrhizae are taken by weight, chopping, mixes;
(2) add the drinking water of 20 times, decoct 120 minutes;
(3) filter, obtain medicinal liquid;
(4) decoct again 2 times according to the method for (2), the medicinal liquid of three decoctions is mixed;
(5) negative pressure concentrated medicament, medicine liquid volume reduces to original 20%;
(6) add appropriate dextrin, spray, granulate, cross 100 mesh sieves;
(7) add the Hirudo of levigation, tabletting after fully mixing;
(8) sterilizing, packaging, to obtain final product.
Test example 1 adopts the routine clinical observation of traditional Chinese medicine composition for treating high blood viscosity 96 of embodiment 1
(1) basic condition
Treatment group: 96 examples, male 39 examples, female's 57 examples, 61 years old mean age.
Sick kind: 34 Cases of Hyperlipemia, coronary heart disease 24 examples, hypertensive patients coronary heart disease 12 examples, cerebral arterial insufficiency 35 examples, cerebral infarction 17 examples, apoplexy sequela 8 examples.
Blood viscous degree: slight (++) 9 examples, moderate (+++～++++) 63 examples, severe (> ++++) 24 examples.
Matched group: 85 examples, male's 37 examples, women's 48 examples.
Age: the right side of fifty 8 examples, 50 years old～70 years old 62 examples, 70 years old above 15 example, mean age 60.79;
Sick kind: hyperlipemia 27 examples, coronary heart disease 15 examples, hypertension 9 examples, cerebral arterial insufficiency 33 examples, cerebral infarction 10 examples, apoplexy sequela 6 examples.
Blood viscous degree: slight (++) 7 examples, moderate (+++～++++) 58 examples, severe (> ++++) 20 examples.
Treatment group and matched group on Gender, age, severity extent without significant difference (P > 0.05).
(2) Therapeutic Method
The granule of embodiment 1, the heavy 4g of every bag, each serving 2 bags, boiled water is taken after mixing it with water, each 1 time sooner or later (being equivalent to the Chinese medicine decocting dosage of clothes every day).Sooner or later each 1 time, take medicine continuously 1 month, be 1 course for the treatment of.
(3) see capsule index
3.1 blood are hidden ftheoloqical measurements
Whole blood viscosity, plasma viscosity: the LIANG--100 blood viscometer, the plasma viscosity meter that produce by Shanghai Medical Students.Shanghai Medical Univ produces biomedical data process computer.Beijing medical equipment repairing factory production centrifugation device.Measure whole blood contrast viscosity with blood capillary method, the centrifugal 5min of remaining turn/min of blood 3000, gets blood plasma and surveys its viscosity.
Erythrocyte sedimentation rate, hematocrit, erythrocyte aggregation index: with Wen's method mensuration erythrocyte sedimentation rate t; Measure packed cell volume with Hematocrit tube.The low high viscosity of cutting of viscosity/whole blood of cutting of erythrocyte aggregation index RE=whole blood.
3.2 symptoms and sign (comprising body weight, blood pressure, abdomen circle, body of the tongue, tongue fur, pulse condition)
(4) efficacy analysis
4.1 criterion of therapeutical effect
Effective: after treatment, clinical symptoms disappears substantially, and whole blood viscosity is down to person's normal range.
Effective: cardinal symptom disappears or obviously improves, and whole blood viscosity before drops to and approaches reference value.
Invalid: clinical symptoms is not improved, the blood viscosity not obvious person that declines.
4.2 therapeutic outcome
In treatment group 96 examples, effective 31 examples, account for 32.3%; Effective 55 examples, 57.3%; Invalid 10 examples, account for 10.4%; Total effective rate is 89.6%.Matched group 85 examples, effective 19 examples, account for 22.3%; Effective 48 examples, account for 56.5%; Invalid 18 examples, account for 21.2%; Total effective rate is 78.8%.Compare significant difference (P < 0.025) for two groups.
Treatment group was taken medicine after 1 course for the treatment of, patient's T-CHOL, triglyceride all have decline (P < 0.01, P < 0.001), hdl level improves (P < 0.001), compared with matched group, all there were significant differences.
Symptom and sign: the symptoms such as patient is dizzy, uncomfortable in chest after treatment, limb is numb, asthenia are all obviously improved or eliminate, compared with matched group, there is significant difference (P < 0.01, P < 0.05), dimly red tongue or light fat person transfer pink tongue to more, petechia, ecchymosis obviously improve, and greasy fur on tongue person transfers thin greasy or thin and whitish fur to more.Body weight, abdominal circumference have decline in various degree more, the most obvious person's weight loss 4Kg, and abdominal circumference reduces 6cm.
Test example 2 adopts the traditional Chinese medicine composition for treating high blood viscosity of embodiment 1
Lee × ×, female, 45 years old, teacher.Obesity 2 years, nearly May is dizzy increases the weight of gradually, have a blood test in certain hospital that viscosity is high and glue (++++), T-CHOL 8.7mmol/L, microcirculation severe obstacle.Patient is dizzy and weigh.Limbs fatigue, xerostomia, red tongue with thin fur, root are micro-greasy, and thready and hesitant pulse card belongs to deficiency of both vital energy and Yin, and the time of stasis of blood essential resistance of turbid, controls the Chinese medicine composition that gives embodiment 1.Take after 10 doses, patient feels that whole body is comfortable, and dizzy weight gradually released, take again 10 doses, the clear order of medicine aftersensation head is refreshing, and all diseases disappear, and conscious abdominal circumference before reduces, after 30 doses of the continuous Chinese medicine compositions that takes embodiment 1, drug withdrawal first quarter moon, check blood viscosity is normal, T-CHOL 3.6mmol/L, microcirculation normal, abdominal circumference reduces 4.5cm.The next day of advising patient, take 1 dose, after treatment.
Test example 3 adopts the traditional Chinese medicine composition for treating hyperlipemia of embodiment 2
King ×, female, 58 years old, obesity, previously had hypertension, diabetes medical history, hyperlipemia medical history.Patient's giddy, without very dizzy sense, right side limbs are weak, and red tongue tongue is greasy in vain.Have a medical check-up: T-CHOL 6.5mmol/L, triglyceride 3.5mmol/L, LDL-C 3.1mmol/L, stringy pulse card belongs to essential resistance of turbid phlegm, and the time of blood stasis due to qi deficiency, controls the Chinese medicine composition that gives embodiment 2.Take after 7 doses, patient is dizzy to take a turn for the better, and limbs are strong, after 90 doses of continuous Chinese medicine compositions that takes embodiment 2, and T-CHOL 5.0mmol/L, LDL-C 2.3mmol/L.Blood pressure, glycemic control are stablized.
Test example 4 adopts traditional Chinese medicine composition for treating hyperlipemia, the high blood viscosity of document 6 and the embodiment of the present invention 1
× ×, man, 65 years old, retired employees.Obesity, dizziness headache, has hypertension, cerebral infarction medical history 5 years, and diabetes 10 years, by insulin control blood glucose.Dizzyly over nearly 2 days increase the weight of gradually the viscosity of having a blood test high sticky (+++), T-CHOL 8.7mmol/L, microcirculation severe obstacle.Patient's hemiplegia, giddy and weigh.Xerostomia, lip is purple dark, and red tongue tongue is white thick greasy, stringy and rolling pulse.Card belongs to the time of stasis of blood essential resistance of turbid, controls to give document 6 and write out a prescription 10 doses, and symptom is not improved, and still has dizziness, headache, nausea and vomiting, hemiplegia, polyphagia polydipsia.Then change into after 60 doses of the Chinese medicine compositions of the embodiment of the present invention 1, check blood viscosity is normal, T-CHOL 3.1mmol/L, and microcirculation normal, limb adynamia takes a turn for the better, nervous basic disappearance uncomfortable in chest.The next day of advising patient, take 1 dose, after treatment.
The above embodiment has only expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (8)
1. one kind is reduced the Chinese medicine composition of blood viscosity and blood fat, it is characterized in that, this Chinese medicine composition is made up of the crude drug of following weight portion: Radix Astragali 10-60 part, Rhizoma Chuanxiong 5-30 part, Pheretima 3-18 part, Hirudo 1.5-9 part, Rhizoma Alismatis 10-30 part, Fructus Crataegi 10-30 part, Radix Salviae Miltiorrhizae 10-35 Fen, Herba Siegesbeckiae 15-30 part, Semen Cassiae 10-30 part, Sargassum 5-30 part, Radix Glycyrrhizae 5-30 part.
2. the Chinese medicine composition of reduction blood viscosity according to claim 1 and blood fat, it is characterized in that, this Chinese medicine composition is made up of the crude drug of following weight: 30 parts of the Radixs Astragali, 6 parts of Rhizoma Chuanxiongs, 6 parts of Pheretimas, 1.5 parts of Hirudos, 15 parts of Rhizoma Alismatis, 15 parts of Fructus Crataegis, Radix Salviae Miltiorrhizae 30 15 parts of Fen, Herba Siegesbeckiaes, 15 parts of Semen Cassiaes, 10 parts of Sargassums, 6 parts, Radix Glycyrrhizae.
3. the Chinese medicine composition of reduction blood viscosity according to claim 1 and blood fat, it is characterized in that, this Chinese medicine composition is made up of the crude drug of following weight: 60 parts of the Radixs Astragali, 15 parts of Rhizoma Chuanxiongs, 12 parts of Pheretimas, 3 parts of Hirudos, 30 parts of Rhizoma Alismatis, 30 parts of Fructus Crataegis, Radix Salviae Miltiorrhizae 15 30 parts of Fen, Herba Siegesbeckiaes, 30 parts of Semen Cassiaes, 25 parts of Sargassums, 10 parts, Radix Glycyrrhizae.
4. according to the reduction blood viscosity described in claim 1-3 any one and the Chinese medicine composition of blood fat, it is characterized in that, described Chinese medicine composition is pill, tablet, powder, capsule or granule.
5. a method of preparing the Chinese medicine composition of reduction blood viscosity described in claim 1-4 any one and blood fat, is characterized in that, comprises the following steps:
(1) except Hirudo, by other 10 kinds of crude drug choppings, mix, decoct with water, filter, obtain medicinal liquid;
(2) negative pressure concentrated medicament, medicine liquid volume reduces to original 20-30%;
(3) by Hirudo levigation, join in the medicinal liquid in step (2), fully mix, obtain described Chinese medicine composition.
6. preparation according to claim 5 reduces the method for the Chinese medicine composition of blood viscosity and blood fat, it is characterized in that, adds crude drug weight 40-60 water doubly in described step (1), decocts each 1.5-2.5 hour 3-4 time.
7. preparation according to claim 5 reduces the method for the Chinese medicine composition of blood viscosity and blood fat, it is characterized in that, in described step (2), negative pressure is concentrated, and medicine liquid volume is reduced to original 25%.
8. the method that reduces the Chinese medicine composition of blood viscosity and blood fat according to the preparation described in claim 5-7 any one, is characterized in that, gets Chinese medicine composition, adds conventional adjuvant, makes tablet, pill, powder, capsule or granule.
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| CN106266320A (en) * | 2015-06-11 | 2017-01-04 | 葛以东 | A kind of formula controlling high blood viscosity |
| CN105663794A (en) * | 2016-04-11 | 2016-06-15 | 烟台市蓝洋之草医药生物科技有限公司 | Application of traditional Chinese medicine composition in preparation of medicine for treating hyperlipidemia |
| CN105816696A (en) * | 2016-04-11 | 2016-08-03 | 烟台市蓝洋之草医药生物科技有限公司 | Traditional Chinese medicinal composition for treating hyperlipidemia |
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Non-Patent Citations (3)
| Title |
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| 国医大师朱良春教授治疗原发性高血压验案赏析;高尚社;《中国中医药现代远程教育》;20101208;第8卷(第23期);第8-9页 * |
| 米一鹗.双降汤.《首批国家级名老中医效验秘方精选(续集)》.1999,第109-110页. * |
| 高尚社.国医大师朱良春教授治疗原发性高血压验案赏析.《中国中医药现代远程教育》.2010,第8卷(第23期),第8-9页. |
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