CN102813751B - Wound treatment agent - Google Patents
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- CN102813751B CN102813751B CN201210281625.0A CN201210281625A CN102813751B CN 102813751 B CN102813751 B CN 102813751B CN 201210281625 A CN201210281625 A CN 201210281625A CN 102813751 B CN102813751 B CN 102813751B
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- 206010052428 Wound Diseases 0.000 title claims abstract description 57
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- 230000029663 wound healing Effects 0.000 abstract description 13
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Abstract
The invention relates to a wound treatment agent prepared by using traditional Chinese medicine materials. The wound treatment agent is used for treating wounds and promoting wound healing. The wound treatment agent provided by the invention is prepared from Taiwan beautyberry leaf, dry or fresh longleaf garden burnet root, rosewood heart wood, dry or fresh bunge corydalis herb, myrrh, ligusticum, salvia chinensis, prepared rehmannia root, redroot gromwell, and licorice root. The medicine materials are decocted according to a certain ratio; the obtained mixture is filtered; and the filtrate is concentrated, such that a traditional Chinese medicine liquid with a certain concentration is prepared. The medicine liquid has disinfecting and sterilizing effects of common wound sterilizing liquids, and has a fast haemostatic effect which can not be provided by current wound sterilizing liquids. Also, the wound treatment agent provided by the invention also has a wound healing promoting effect. The wound treatment agent provided by the invention is prepared by using pure natural traditional Chinese medicine materials, and does not contain hormone. The preparation method is simple, and the cost is low.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of wound, relate in particular to and a kind ofly by raw material of Chinese medicine, be prepared from, for the treatment of wound, promote the wound treatment agent of wound healing.
Background technology
For the product of wound disinfection, be at present mainly to take ethanol and iodine tincture as main; But such disinfectant can only be killed antibacterial or microorganism that place is general, there is no anastalsis and the healing of wound is not had to direct effect yet.It is medical alcohol 20-50 part, trichloro hydroxyl diphenyl ether 6-15 part, Herba Clinopodii Polycephali 10-25 part, oils and fats Radix Hyperici Monogyni (Herba Hyperici Monogyni) extract 5-18 part that Chinese patent CN102462732A has announced " a kind of Wound disinfectant and preparation method thereof " its active substance.Trichloro hydroxyl diphenyl ether is wherein conventional antimicrobial activity agent, is usually used in disinfecting articles for use, as medicated soap, body lotion, handwashing liquid etc.; Herba Clinopodii Polycephali is wherein for hemostasis, oils and fats Radix Hyperici Monogyni (Herba Hyperici Monogyni) extract for blood circulation promoting and blood stasis dispelling, and this disinfectant solution is a kind of disinfectant solution that can promote wound healing.But due to Herba Clinopodii Polycephali, oils and fats Radix Hyperici Monogyni (Herba Hyperici Monogyni) extractive content very little, can only play the effect that makes the preliminary convergence of wound; After using this disinfectant solution to process wound, also need to smear the ointment that promotes wound healing.Therefore Chinese patent CN102462732A announces " a kind of Wound disinfectant and preparation method thereof " contained Chinese medicine ingredients is few, can only be as the disinfectant solution of processing wound, and do not there is the effect that has quick-acting haemostatic powder and promote wound healing.
Summary of the invention
The object of this invention is to provide and a kind ofly by natural Chinese medicines material, made, for clearing up wound quick-acting haemostatic powder, promote the wound treatment agent of wound healing.
Technical scheme of the present invention:
A wound treatment agent is that the raw material of Chinese medicine by following weight parts decocts with water, filter, the concentrated water extract forming; The weight of water extract is that 0.5-2.0 is doubly to the weight of medical material dry product; Folium Callicarpae Formosanae 10-30 part, Radix Sanguisorbae dry product 6-15 part or fresh goods 30-90 part, Lignum Dalbergiae Odoriferae 3-6 part, Herba Corydalis Bungeanae dry product 9-15 part or fresh goods 30-60 part, Myrrha 3-9 part, Radix Angelicae Sinensis 6-12 part, Herba Salviae Chinensis 6-12 part, Radix Rehmanniae Preparata 15-25 part, Radix Arnebiae (Radix Lithospermi) 6-12 part, Radix Glycyrrhizae 15-30 part.
Folium Callicarpae Formosanae: property is flat, and taste is micro-pungent, bitter; Hemostasis and anti-inflammation, dissipating blood stasis for subsidence of swelling.For traumatic hemorrhage, epistaxis, gingiva bleeding gingival hemorrhage, sprain swell and ache, suppurative skin ulcer, burn.
Radix Sanguisorbae: cold nature; Bitter in the mouth, acid, puckery; Return liver, large intestine channel; Cooling blood for hemostasis, removing toxic substances sore.For burn due to hot liquid or fire, carbuncle sore tumefacting virus.
Lignum Dalbergiae Odoriferae: warm in nature; Acrid in the mouth; Return liver, spleen channel; Promoting flow of QI and blood, pain relieving, hemostasis.For injury from falling down, traumatic hemorrhage.
Herba Corydalis Bungeanae: cold in nature; Bitter in the mouth, pungent; GUIXIN, spleen channel; Heat clearing away poison, subduing inflammation.
Myrrha: property is flat; Bitter in the mouth, pungent; GUIXIN, liver, spleen channel; Promoting blood circulation and stopping pain, detumescence and promoting granulation.For external wounds traumatic injury, skin infection carbuncle, all pain cards of stagnation of blood stasis.
Radix Angelicae Sinensis: warm in nature; Sweet in the mouth, pungent; Return liver, the heart, spleen channel; Enrich blood and invigorate blood circulation.For rheumatic arthralgia, traumatic injury.
Herba Salviae Chinensis: property is flat, bitter in the mouth, pungent; Heat-clearing and toxic substances removing, blood circulation promoting regulates qi pain relieving.
Radix Rehmanniae Preparata: slightly warm in nature; Sweet in the mouth; Return liver, kidney channel; The YIN nourishing of enriching blood, beneficial essence is filled out marrow.
Radix Arnebiae (Radix Lithospermi): cold in nature; Sweet in the mouth, salty; GUIXIN, Liver Channel; Removing heat from blood, invigorates blood circulation, removing toxic substances rash.For heat in blood poison, contain, macule purple is black, skin infection, eczema, burn due to hot liquid or fire.
Radix Glycyrrhizae: property is flat; Sweet; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, carbuncle sore tumefacting virus, cushion toxicity, strong.
Chinese medical discrimination: hinder stagnation of QI and blood, stagnation of QI and blood is obstructed, stagnation of QI and blood may bring about pain; General rule is wet not long-pending, wet long-pending mould corruption; Its rule for the treatment of is blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, control malicious damp eliminating, removing the necrotic tissue and promoting granulation.In we, Folium Callicarpae Formosanae, Lignum Dalbergiae Odoriferae, Radix Arnebiae (Radix Lithospermi), Herba Corydalis Bungeanae are monarch drug; Wherein Folium Callicarpae Formosanae, Lignum Dalbergiae Odoriferae are used for hemostasis and anti-inflammation, dissipating blood stasis for subsidence of swelling, and Radix Arnebiae (Radix Lithospermi), Herba Corydalis Bungeanae are used for heat-clearing and toxic substances removing, promoting blood circulation and cooling blood.Radix Sanguisorbae, Myrrha, Radix Angelicae Sinensis, Radix Rehmanniae Preparata are ministerial drug, and wherein Myrrha promoting blood circulation and stopping pain, Radix Rehmanniae Preparata are enriched blood, and auxiliary Folium Callicarpae Formosanae, Lignum Dalbergiae Odoriferae are with blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic; The dehumidifying of invigorating blood circulation of Radix Sanguisorbae cooling blood for hemostasis, Radix Angelicae Sinensis, auxiliary Radix Arnebiae (Radix Lithospermi), Herba Corydalis Bungeanae are with removing damp-heat, blood circulation promoting regulates qi.Radix Glycyrrhizae is with heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong.
In we, contain multi-flavor haemostatic medicament, there is good hemostasia effect; Therefore when cleaning bleeding wounds, can play the effect of quick-acting haemostatic powder; Be particularly useful for open air or family emergency.
In we, also contain the medicine of multi-flavor blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, anti-inflammatory analgetic, can promote the healing of wound; Therefore wound treatment agent of the present invention can be used as the drug use of healing of wound.Owing to containing the medicine that mostly is heat-clearing and toxic substances removing, removing heat from blood effect in wound treatment agent of the present invention; Therefore the present invention is applicable equally to burn and scald.
In order to improve the effect of above-mentioned wound treatment agent healing of wound, preferably, the weight portion of described raw material of Chinese medicine is: 10 parts of Folium Callicarpae Formosanaes, 6 parts of Radix Sanguisorbae dry products, 3 parts of Lignum Dalbergiae Odoriferaes, Herba Corydalis Bungeanae dry product 9-15 part, Myrrha 8-9 part, Radix Angelicae Sinensis 9-12 part, Herba Salviae Chinensis 8-12 part, Radix Rehmanniae Preparata 20-25 part, Radix Arnebiae (Radix Lithospermi) 6-9 part, Radix Glycyrrhizae 15-30 part; The weight of described water extract is that 0.5-0.8 is doubly to the weight of medicinal raw material.Wound treatment agent now, as the drug use of healing of wound, is applied in wound, every day 3-6 time.
Can be larger owing to clearing up the amount of the needed wound treatment agent of wound, but less demanding to its healing effect, therefore preferred, the weight portion of described raw material of Chinese medicine is: 30 parts of Folium Callicarpae Formosanaes, 15 parts of Radix Sanguisorbae dry products, 6 parts of Lignum Dalbergiae Odoriferaes, 12 parts of Herba Corydalis Bungeanae dry products, 3 parts of Myrrhas, 6 parts of Radix Angelicae Sinensis, 12 parts of Herba Salviae Chinensiss, 15 parts of Radix Rehmanniae Preparata, 12 parts of Radix Arnebiae (Radix Lithospermi)s, 20 parts, Radix Glycyrrhizae; The weight of described water extract is that 1.5-2.0 is doubly to the weight of medical material dry product.Now wound treatment agent is used as wound cleaning liquid, can not cause waste.
Preparation method: take raw material by above-mentioned weight portion, decoct with water, filter, concentrate and make water extract.The water extract of gained can be continued to the concentrated adjuvant that adds and make unguentum.
Bacteriostatic test:
Slant culture one ring of depletion Staphylococcus aureus, escherichia coli, Candida albicans, bacillus pyocyaneus is inoculated in respectively in broth bouillon, cultivate after 24 hours for 37 ℃, respectively get 0.2 milliliter and be inoculated in 3 plating mediums, get respectively wound treatment agent prepared in the embodiment 1-3 of equivalent, drip in 3 plating mediums respectively; After effect 3min, detect sterilization rate; Result is as table 1;
Table 1
| ? | Staphylococcus aureus | Escherichia coli | Candida albicans | Bacillus pyocyaneus |
| Embodiment 1 | 99.94 | 99.94 | 99.96 | 99.93 |
| Embodiment 2 | 99.94 | 99.95 | 99.95 | 99.94 |
| Embodiment 3 | 99.95 | 99.95 | 99.96 | 99.94 |
Animal experiment:
Mice is cut to the impact in tail bleeding time: 60 of healthy Kunming mouses, male and female half and half, body weight are suitable, are divided into 6 groups, test group 1-3 group, matched group 1-2 and blank group.Test 1-3 adopts respectively wound treatment agent prepared in embodiment 1-3; Wound disinfectant (hereinafter referred to as disinfectant solution), medical alcohol that matched group 1-2 adopts respectively Chinese patent CN102462732A to announce; Blank group is not carried out any processing to wound.
The about 1cm place quick shearing afterbody that makes progress in mouse tail tip with very sharp shears, and with stopwatch, clock immediately, with wound treatment agent, medical alcohol, the disinfectant solution of same dose, wound is cleaned respectively, every 1min once simultaneously.Constantly with filter paper, inhale the blood flowing out simultaneously.From cutting tail, start to be during this period of time mice to stopped bleeding and cut the tail bleeding time.
Result of the test is as table 2;
Table 2
| ? | Test group 1 | Test group 2 | Test group 3 | Matched group 1 | Matched group 2 | Blank group |
| Bleeding time | 522-615s | 469-518s | 465-517s | 967-1122s | Be greater than 1500s | Be greater than 1500s |
Table 2 explanation, the too late sterilizing effect that possesses medical alcohol of wound treatment agent of the present invention, and possess haemostatic effect; And its haemostatic effect is much larger than the haemostatic effect of disinfectant solution.
After the wound of mice is no longer hemorrhage, carry out suture operation, test group 1-3 and matched group 1 are carried out to wound healing viewing test; Wherein test group 1-3 continues to adopt prepared wound treatment agent in embodiment 1-3, smears wound every day 6 times; Matched group 1 adopts disinfectant solution to smear wound every day; Blank group is only carried out sterilizing processing to wound.Treat that it is healing that wound covers without edema pain phenomenon by epidermis completely.Result of the test is as table 3;
Table 3
| ? | Test group 1 | Test group 2 | Test group 3 | Matched group 1 | Blank group |
| Healing time | 16-19 days | 12-16 days | 12-16 days | Be greater than 21 days | Be greater than 21 days |
Table 3 explanation, wound treatment agent of the present invention also possesses the effect that promotes wound healing; And disinfectant solution does not have obvious facilitation to wound healing.
Beneficial effect of the present invention:
Wound treatment agent of the present invention adopts natural Chinese medicine material to be prepared from, and does not contain hormone.Its preparation method is simple, with low cost.When its concentration is lower, can be used for cleaning a wound, can sterilizing and can play anastalsis; When its concentration is higher, can be used as the drug use that promotes wound healing, can make wound healing.Therefore, wound treatment agent of the present invention is a kind of sterilization, sterilization, hemostasis, promotion wound healing function, wound treatment agent with low cost of integrating.
The specific embodiment
Embodiment 1
Get Folium Callicarpae Formosanae 30kg, Radix Sanguisorbae dry product 15kg, Lignum Dalbergiae Odoriferae 6kg, Herba Corydalis Bungeanae dry product 12kg, Myrrha 3kg, Radix Angelicae Sinensis 6kg, Herba Salviae Chinensis 12kg, Radix Rehmanniae Preparata 15kg, Radix Arnebiae (Radix Lithospermi) 12kg, Radix Glycyrrhizae 20kg, decoct with water, filter, be concentrated into 230kg; Cooling, encapsulation.
Embodiment 2
Get Folium Callicarpae Formosanae 10kg, Radix Sanguisorbae dry product 6kg, Lignum Dalbergiae Odoriferae 3kg, Herba Corydalis Bungeanae dry product 9kg, Myrrha 8kg, Radix Angelicae Sinensis 9kg, Herba Salviae Chinensis 8kg, Radix Rehmanniae Preparata 25kg, Radix Arnebiae (Radix Lithospermi) 6kg, Radix Glycyrrhizae 30kg, decoct with water, filter, be concentrated into 91kg; Cooling, encapsulation.
Embodiment 3
Get Folium Callicarpae Formosanae 10kg, Radix Sanguisorbae dry product 6kg, Lignum Dalbergiae Odoriferae 3kg, Herba Corydalis Bungeanae dry product 15kg, Myrrha 9kg, Radix Angelicae Sinensis 12kg, Herba Salviae Chinensis 12kg, Radix Rehmanniae Preparata 20kg, Radix Arnebiae (Radix Lithospermi) 9kg, Radix Glycyrrhizae 15kg, decoct with water, filter, be concentrated into 56kg; Cooling, encapsulation.
Claims (1)
1. a wound treatment agent, is characterized in that, be that the raw material of Chinese medicine by following weight parts decocts with water, filter, the concentrated water extract forming; The weight portion of described raw material of Chinese medicine is: 30 parts of Folium Callicarpae Formosanaes, 15 parts of Radix Sanguisorbae dry products, 6 parts of Lignum Dalbergiae Odoriferaes, 12 parts of Herba Corydalis Bungeanae dry products, 3 parts of Myrrhas, 6 parts of Radix Angelicae Sinensis, 12 parts of Herba Salviae Chinensiss, 15 parts of Radix Rehmanniae Preparata, 12 parts of Radix Arnebiae (Radix Lithospermi)s, 20 parts, Radix Glycyrrhizae; The weight of described water extract is that 1.5-2.0 is doubly to the weight of medical material dry product.
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| CN201210281625.0A CN102813751B (en) | 2012-08-09 | 2012-08-09 | Wound treatment agent |
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| CN103751543B (en) * | 2014-01-15 | 2016-04-20 | 薛晓晓 | A kind of Chinese herbal medicine for wound care and preparation method thereof |
| CN105560620A (en) * | 2015-12-25 | 2016-05-11 | 马真真 | Trauma treatment traditional Chinese medicine preparation |
| CN105770382A (en) * | 2016-05-30 | 2016-07-20 | 孙兆玲 | Traditional Chinese medicine composition for nursing wounds of middle-aged and elderly people |
| CN105902701A (en) * | 2016-06-29 | 2016-08-31 | 山东大学第二医院 | Traditional Chinese medicine composition for treating infection at outlet of peritoneal dialysis tube |
| CN109200220A (en) * | 2018-11-29 | 2019-01-15 | 吴斌 | A kind for the treatment of of wounds Chinese medicine composition and preparation method thereof |
| CN111467433B (en) * | 2020-05-27 | 2021-08-20 | 中国人民解放军空军军医大学 | A topical Chinese medicinal composition and paste for promoting wound healing, and its preparation method |
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