CN102805769B

CN102805769B - Emergency medicine for treating nasal hemorrhage

Info

Publication number: CN102805769B
Application number: CN2012102803049A
Authority: CN
Inventors: 辛丽丽
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-08-08
Filing date: 2012-08-08
Publication date: 2013-09-04
Anticipated expiration: 2032-08-08
Also published as: CN102805769A

Abstract

The invention discloses an emergency medicine for treating nasal hemorrhage, which solves the problem of treating nasal hemorrhage. The invention is characterized in that the emergency medicine is processed by the following traditional Chinese medicines in parts by weight: 6-10 parts of anchusa azurea, 8-15 parts of astragalus mongholicus, 2-4 parts of lasiosphaera seu calvatia, 6-10 parts of eggshells, 6-10 parts of angelica sinensis, 8-15 parts of radix paeoniae alba, 6-10 parts of garden burnet root, 8-15 parts of rhizoma nelumbinis and 3-6 parts of radix glycyrrhiza. The clinical experiments prove that the emergency medicine provided by the invention has the characteristics of good efficacy and high safety, thereby being worthy of clinical application and popularization.

Description

A kind of first aid medicine for the treatment of epistaxis

Technical field

The present invention relates to the field of Chinese medicines, be specifically related to treat the first aid medicine of epistaxis.

Background technology

Epistaxis is common emergency treatment prescription on individual diagnosis disease; especially child; about 3/4 all suffered from epistaxis; its reason can be the nose part and general disease and causing; reason in the nose part is the wound of nose; hands digs the nostril; cause angiorrhexis under the mucosa; hemorrhage, the bending of diaphragm is thin at bent partially convex surface mucosa in the nose in addition, is subject to the air influence of cold air drying; make the dry angiorrhexis of mucosa hemorrhage; also some inflammation such as nasal sinuses nasal sinusitis can make the congested swelling of nasal mucosa, firmly blow one's nose, and nasal mucosa vessels breaks hemorrhage through regular meeting.Present first aid process is exactly that hemostasis by compression is carried out in packing of anterior naris, but also often runs into some epistaxiss clinically, does not particularly have the patient of clear and definite petechia, and is after the said method treatment, still hemorrhage repeatedly.And due to illness the hypertension gerontal patient often is positioned at the nasal cavity posterior segment in the special and epistaxis position of Li Shengli, still hemorrhage common especially repeatedly after above-mentioned doctor trained in Western medicine method treatment.And the blood vessel of sclerosis is subjected to hypertensive impact and breaks hemorrhagely, and amount is many when hemorrhage, and the blood vessel that breaks is difficult for healing voluntarily, often breaks with tremendous force, and causes patient's fear, and is anxious, increases the weight of hypertension.

Summary of the invention

Technical assignment of the present invention is at the deficiencies in the prior art, and the first aid medicine of the sure treatment epistaxis of a kind of curative effect is provided.

The technical scheme that the present invention solves its technical problem is: a kind of first aid medicine for the treatment of epistaxis, it is characterized in that being processed by plurality of Chinese, its composition of raw materials and weight proportion are: 6 ~ 10 parts of Folium Fumicis Dentatis, 8 ~ 15 parts of the Radixs Astragali, 2 ~ 4 parts of Lasiosphaera Seu Calvatia, 6 ~ 10 parts of Ovum Gallus domesticus crustas, 6 ~ 10 parts of Radix Angelicae Sinensis, 8 ~ 15 parts of the Radix Paeoniae Albas, 6 ~ 10 parts of Radix Sanguisorbaes, 8 ~ 15 parts of Nodus Nelumbinis Rhizomatis, 3 ~ 6 parts in Radix Glycyrrhizae.

Its optimum weight proportioning is: 8 parts of Folium Fumicis Dentatis, 10 parts of the Radixs Astragali, 3 parts of Lasiosphaera Seu Calvatia, 8 parts of Ovum Gallus domesticus crustas, 8 parts of Radix Angelicae Sinensis, 10 parts of the Radix Paeoniae Albas, 8 parts of Radix Sanguisorbaes, 10 parts of Nodus Nelumbinis Rhizomatis, 5 parts in Radix Glycyrrhizae.

Wherein said: Folium Fumicis Dentati is the leaf of polygonaceae plant rumex dentatus Rumex dentatus L..The nature and flavor hardship; Cold in nature.But merit heat-clearing and toxic substances removing; Killing parasites for relieving itching.

The Radix Astragali is the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..Nature and flavor are sweet, temperature.Return lung, spleen channel.But the merit invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.

Lasiosphaera Seu Calvatia is the nearly mature sporophore of the lasiosphaera fenzlii Reics platymiscium lasiosphaera fenzlii Reics Lasiosphaera fenzlii Reich. of ash bag section, Lycoperdon plant calvatia gigantea Calvatia gigantea (Batach. ex Pers.) Lloyd. and purple Lasiosphaera Seu Calvatia C. lilacina Lloyd..The nature and flavor suffering, flat.But the merit heat clearing away, sore-throat relieving, hemostasis.

Ovum Gallus domesticus crusta is for being the hard coat of the ovum of the chicken Gallus gallus domesticus Brisson of Phasianidae animal man.Nature and flavor are lightly seasoned; Property is put down.Return stomach; Kidney channel.Merit can restrain; Antacid; Bone strengthening; Hemostasis; Make eye bright.

Radix Angelicae Sinensis is the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor are sweet, hot, temperature.Return liver, the heart, spleen channel.Merit can be enriched blood and be invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.

The Radix Paeoniae Alba is the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..Nature and flavor hardship, acid are slightly cold.Return liver, spleen channel.But the pain relieving of merit suppressing the hyperactive liver, nourishing blood for regulating menstruation, astringing YIN to stop sweating.

Radix Sanguisorbae is the dry root of rosaceous plant Radix Sanguisorbae Sanguisorba officinalis L. or Radix Sanguisorbae Sanguisorba off icinalis L.var.longifolia (Bert.) the Yu et Li that comes into leaves.Nature and flavor hardship, acid, puckery are slightly cold.Return liver, large intestine channel.But the merit cooling blood for hemostasis, skin ulcer is held back in detoxifcation.

Nodus Nelumbinis Rhizomatis is the dry root stipes portion of nymphaeaceae plant lotus Nelumbo nucifera Gaertn..Nature and flavor are sweet, puckery, and are flat.Return liver, lung, stomach warp.Merit can be stopped blooding, repercussive.

Radix Glycyrrhizae is the dry root of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..Nature and flavor are sweet, and are flat.GUIXIN, lung, spleen, stomach warp.But the merit invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.

Composition principle: the reason that epistaxis produces can be divided into local factor and systemic factor.Local factor person is as wound, foreign body, active chronic inflammation, nasal septum pathological changes, nasal cavity or the tumor of sinus of nose etc. of nose and nasal sinuses.Systemic factor person, the systemic disease that allly cause that arterial pressure and venous pressure increase, disturbances of blood coagulation or antiotasis changes, as chronic diseases such as acute infectious disease, cardiovascular disease, hematopathy, malnutrition or vitamin deficiency and liver, kidney and rheumatic fever, poisoning, hereditary hemorrhagic telangiectasia, endocrine disturbance etc., all can bring out epistaxis.During epistaxis, nasal cavity angiorrhexis, mucosa drying, telangiectasis, coarse, rotten to the corn, ulcer and dry crusts adhere to etc.And epistaxis is equivalent to the epistaxis of traditional medicine record, and " Ling Shu Miraculous Pivot or Divine Axis all kinds of diseases and ailments beginning is given birth to a piece of writing " said: " injury of YANG-collateral leading to outwards bleeding, the excessive then epistaxis of blood." generation of epistaxis also is the result that a variety of causes causes the damage of nose yang collaterals.Clinical application at present mostly is cooling blood for hemostasis and astringing to arrest bleeding is main, but in the practical application, the epistaxis that hemostasis by compression is difficult to prove effective is intenseness of heat often, or be excess-heat, the perhaps high Sheng of liver-yang is so reuse the Folium Fumicis Dentati heat-clearing and toxic substances removing in the prescription of the present invention, the Lasiosphaera Seu Calvatia clearing away heat to stop bleeding, the Radix Sanguisorbae cooling blood for hemostasis; Be aided with the Ovum Gallus domesticus crusta astringing to arrest bleeding, Chinese angelica blood supplementing is invigorated blood circulation, Radix Astragali QI invigorating, and the Radix Paeoniae Alba is nourished blood, Nodus Nelumbinis Rhizomatis hemostasis repercussive, the stasis of blood, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription are not stayed in hemostasis.

Modern pharmacological research shows: the Folium Fumicis Dentati water decoction can make human body myocardium vessel bar shrink tension improve 428.84 ± 58.42mg and 500 ± 80.80mg, can shorten the mice bleeding time 4.5 ± 3.9, with matched group apparent property difference is arranged relatively.The Folium Fumicis Dentati water decoction has activation to thrombin, can make clotting time shorten 5 ~ 6 minutes than normal value.

The specific embodiment

Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.

Embodiment 1, the crude drug weight proportion: Folium Fumicis Dentati 6g, Radix Astragali 8g, Lasiosphaera Seu Calvatia 2g, Ovum Gallus domesticus crusta 6g, Radix Angelicae Sinensis 6g, Radix Paeoniae Alba 8g, Radix Sanguisorbae 6g, Nodus Nelumbinis Rhizomatis 8g, Radix Glycyrrhizae 3g.

Embodiment 2, the crude drug weight proportion: Folium Fumicis Dentati 10g, Radix Astragali 15g, Lasiosphaera Seu Calvatia 4g, Ovum Gallus domesticus crusta 10g, Radix Angelicae Sinensis 10g, Radix Paeoniae Alba 15g, Radix Sanguisorbae 10g, Nodus Nelumbinis Rhizomatis 15g, Radix Glycyrrhizae 6g.

Embodiment 3, the crude drug weight proportion: Folium Fumicis Dentati 8g, Radix Astragali 10g, Lasiosphaera Seu Calvatia 3g, Ovum Gallus domesticus crusta 8g, Radix Angelicae Sinensis 8g, Radix Paeoniae Alba 10g, Radix Sanguisorbae 8g, Nodus Nelumbinis Rhizomatis 10g, Radix Glycyrrhizae 5g.

Exterior-applied formulation preparation and the using method of embodiment 1 ~ 3 are: Chinese medicine Folium Fumicis Dentati of the present invention, the Radix Astragali, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Sanguisorbae, Radix Glycyrrhizae and Nodus Nelumbinis Rhizomatis are decocted with water twice, filtrate concentrates, cold preservation is standby, during use, Lasiosphaera Seu Calvatia, Ovum Gallus domesticus crusta are pulverized, call in the standby cold preservation concentrated filtrate, coat on the kpetrolatum gauze, insert nasal cavity.

Peroral dosage form preparation and the using method of embodiment 1 ~ 3 are: get Chinese medicine Folium Fumicis Dentati of the present invention, the Radix Astragali, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Sanguisorbae, Radix Glycyrrhizae, Nodus Nelumbinis Rhizomatis, Ovum Gallus domesticus crusta and Lasiosphaera Seu Calvatia and decoct with water twice, get filtrate, be divided into twice oral taking sooner or later.

When emergency treatment was used, the first day adopted exterior-applied formulation to insert nasal cavity, cooperates oral above-mentioned peroral dosage form 7 days simultaneously.

Effective combination of said medicine is coordinated mutually, can effectively reach the purpose for the treatment of epistaxis, and side effect is less.The above results is that clinical data proves that fully interrelated data is as follows, wherein studies drug use and is the crude drug weight proportion among the embodiment 3.

1 object and method.

1.1 object: case is selected from January, 2010 to 2011 year 12 moon gate emergency treatment patients, 288 examples, and going into the group standard is 5 minutes bad persons of effect of epistaxis hemostasis by compression.

1.2 method.

1.2.1 grouping: be divided into two groups immediately: 144 examples are organized in treatment, male 76 examples, women 68 examples.10 ~ 42 years old age, average 33 years old.Matched group 144 examples, male 78 examples, women 66 examples, 11 ~ 40 years old age, average 32 years old.Two groups of ages, sex, extent of hemorrhage comparing differences do not have significance.

1.2.2 Therapeutic Method: matched group first day vaseline gauze is filled nasal cavity, the oral vitamin K4 sheet 4mg that continues, VITAMIN C TABLET 0.2g, every day 3 times, conventional therapy 7d.Day embodiment of the invention 3 gained exterior-applied formulations are filled nasal cavity headed by the treatment prescription case, the oral embodiment of the invention 3 gained Chinese medicine decoction that continue, once a day, conventional therapy 7d.

1.2.3 observation index: amount of bleeding and times of bleeding situation of change and tolerance level index.Tolerance level index: adopt patient from marking scales: will not have significant discomfort, well-tolerated is decided to be 10 fens, and have a strong impact on life, can not tolerate and be decided to be 0 fen, and given a mark according to the impression of oneself by the patient.

1.2.4 curative effect determinate standard: produce effects: epistaxis stops fully.Effectively: amount of bleeding and number of times obviously reduce.Invalid: nasal cavity continues hemorrhage repeatedly.

1.2.5 statistical analysis carries out statistical analysis with SPSS 13.0, P＜0.05 expression has the significance meaning.

2 results.

2.1 treatment back tolerance level index relatively: the treatment group is 7 ± 3.8 minutes, and matched group is 4 ± 2.3 minutes, and the treatment group is apparently higher than matched group (P＜0.05).

2.2 the curative effect of two groups of cases relatively: see the following form, obvious effective rate and total effective rate treatment group obviously are better than matched group (P＜0.05).

2.3 untoward reaction situation: two groups there is no the obvious adverse reaction report.

3. conclusion.

This result of study shows that the present invention treats the epistaxis determined curative effect, is worthy of promotion and application.

Claims

1. first aid medicine for the treatment of epistaxis, it is characterized in that being processed by plurality of Chinese, its composition of raw materials and weight proportion are: 6 ~ 10 parts of Folium Fumicis Dentatis, 8 ~ 15 parts of the Radixs Astragali, 2 ~ 4 parts of Lasiosphaera Seu Calvatia, 6 ~ 10 parts of Ovum Gallus domesticus crustas, 6 ~ 10 parts of Radix Angelicae Sinensis, 8 ~ 15 parts of the Radix Paeoniae Albas, 6 ~ 10 parts of Radix Sanguisorbaes, 8 ~ 15 parts of Nodus Nelumbinis Rhizomatis, 3 ~ 6 parts in Radix Glycyrrhizae.

2. a kind of first aid medicine for the treatment of epistaxis according to claim 1 is characterized in that its weight proportion is: 8 parts of Folium Fumicis Dentatis, 10 parts of the Radixs Astragali, 3 parts of Lasiosphaera Seu Calvatia, 8 parts of Ovum Gallus domesticus crustas, 8 parts of Radix Angelicae Sinensis, 10 parts of the Radix Paeoniae Albas, 8 parts of Radix Sanguisorbaes, 10 parts of Nodus Nelumbinis Rhizomatis, 5 parts in Radix Glycyrrhizae.