CN102784359A

CN102784359A - Medicine for treating senile dementia and preparation method of medicine

Info

Publication number: CN102784359A
Application number: CN2012102802169A
Authority: CN
Inventors: 冯安华
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-08-08
Filing date: 2012-08-08
Publication date: 2012-11-21

Abstract

The invention relates to a medicine for treating senile dementia and a preparation method of the medicine. According to the preparation method, dangshen, angelica sinensis, prepared rehmannia root, fructus lycii, eucommia ulmoides, salviae miltiorrhizae, rhizoma acori graminei, ligusticum wallichii, astragalus mongholicus, fructus alpiniae oxyphyllae, walnut, polygala tenuifolia, arisaema cum bile, cistanche, cortex albiziae, radix ophiopogonis, ligustrum lucidum ait, radix paeoniae alba, semen raphani, dogwood fruit, semen cuscutae, trichosanthes kirilowii maxim, polygonum multiflorum, curcuma zedoary, peach kernel, tenodera aridifolia stoll and the like are cleaned and are then added with water to be decocted, decoction liquid is obtained, ordinary auxiliary materials are added after concentration, purified water is added until the crude medicine content is 1g/ml, the filling encapsulation and the sterilization are carried out, and an oral liquid preparation is prepared. The medicine can tonify the spleen, clear the damp, flush phlegm and remove stasis, and a good curative effect is realized on treating the senile dementia. Through clinical observation, the efficiency of the medicine is 96 percent. Side effects such as injury on human visceral organs caused by western medicine preparations are avoided.

Description

A kind of medicine of treating alzheimer disease and preparation method thereof

Technical field

The present invention relates to a kind of medicine of treating alzheimer disease, particularly a kind of is the Chinese medicine of the treatment alzheimer disease of crude drug preparation with Chinese medicine.The invention still further relates to the method for preparing of this medicine.

Background technology

Alzheimer disease is the one group of syndrome that causes owing to multiple reasons such as neurodegeneration, cerebrovascular disease, infection, wound, tumor, Nutrition and Metabolism obstacles; It is the persistent comprehensive hypophrenia that patient occurs under the state of Consciousness; Showing as memory, computing power, judgment, attention, abstract thinking ability, language function goes down; Emotion and behavior disorder are lived on one's own life and the ability to work forfeiture.

Doctor trained in Western medicine is thought: alzheimer disease is to be a kind of chronic progressive external mental sickness of pathological characters with the cerebral tissue diffuse atrophy; Because the cerebral tissue atrophy narrows down gyrus, the broadening of brain ditch; Brain cortex cell reduces; The neurocyte inner lipid increases in addition, neural no fibre matting and granulovacuolar degeneration, thereby cause comprehensive infringement to acquired intelligence, memory and personality.

The traditional Chinese medical science thinks that alzheimer disease belongs to traditional Chinese medical science ancient books contained " forgetful ", " literary composition is silly ", " strongly fragrant disease " category.The cause of disease of alzheimer disease is a deficiency in origin and excess in superficiality, and deficiency in origin is meant the void of kidney spleen, the real stagnation of QI, blood stasis, the expectorant knot of being meant of mark.Kidney storing essence, the smart marrow of giving birth to fills on the marrow in brain, and then the people's is resourceful.The people declines withered to old kidney essense, be difficult to give birth to marrow, to spiritually barren; Gods dereliction and primary disease takes place, insufficiency of the spleen then dysfunction of the spleen in transportation and transformation, the stagnation of QI is satisfied and is given birth to; The stagnation of QI causes that body fluid cloth is defeated freely not to be prone to become expectorant, and thrombosis and cause the stasis of blood is because the internal resistance of the expectorant stasis of blood; QI and blood is difficult to annotate in head, and brain is become homeless foster, and with the passing of time brains are withered and send out and be primary disease.

Aspect the treatment alzheimer disease, the traditional Chinese medical science is that the principle of treatment prescription is sent medicine with kidney tonifying, essence replenishing benefit marrow, comes slow down aging, prevents and treats alzheimer disease at present; Doctor trained in Western medicine Acetylcholinesterase (AchE) inhibitor then commonly used comprises tacrine, aricept, and Exelon, galantamine, through improving choline neurotransmission medicine, perhaps agent of brain metabolic activation and cerebral circulation improving agent reach therapeutic purposes.But this type of medicine often contains hormone.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine of treating alzheimer disease, natural pure, the safety non-toxic of this medicine does not have dependency, is free from side effects.

The method for preparing that this medicine is provided in addition is an another object of the present invention.

Medicine of the present invention is that crude drug prepares by following parts by weight of traditional Chinese medicines:

Radix Codonopsis 45-55 Radix Angelicae Sinensis 25-35 Radix Rehmanniae Preparata 25-35

Fructus Lycii 30-40 Cortex Eucommiae 25-35 Radix Salviae Miltiorrhizae 25-35

Rhizoma Acori Graminei 15-25 Rhizoma Chuanxiong 20-30 Radix Astragali 30-40

Fructus Alpiniae Oxyphyllae 25-35 semen juglandis 25-35 Radix Polygalae 25-35

Arisaema Cum Bile 15-25 Herba Cistanches 15-25 Cortex Albiziae 15-25

Radix Ophiopogonis 25-35 Fructus Ligustri Lucidi 15-25 Radix Paeoniae Alba 20-30

Semen Raphani 15-25 Fructus Corni 20-30 Semen Cuscutae 20-30

Fructus Trichosanthis 20-30 Radix Polygoni Multiflori 20-30 Rhizoma Curcumae 15-25

Semen Persicae 15-25 Ootheca Mantidis 15-25.

Can said medicine be processed on the pharmaceutics any dosage form such as tablet, pill, powder, capsule, the present invention is oral liquid preferably.

The concrete method for preparing of above-mentioned each component being processed oral liquid according to the invention is:

Above-mentioned medicaments in part by weight is cleaned up the back mix homogeneously, add two times of weight parts waters, decoct each 20 minutes 2～4 times; Collecting decoction filters, and filtrating is condensed into the clear paste of 70 ℃ of relative densities 1.15～1.18; Cold preservation is left standstill, and gets supernatant and filters, and adds conventional adjuvant in the filtrating; Mixing, adding purified water is 1g/ml to containing the crude drug amount, oral liquid formulations is processed in embedding, sterilization.

Method for using: oral, each 1 bag, every bag of 500ml, every day three times.

The traditional Chinese medical science claims that alzheimer disease is a deficiency in origin and excess in superficiality, and deficiency in origin is meant the void of kidney spleen, the real stagnation of QI, blood stasis, the expectorant knot of being meant of mark.The parties to the kidney and spleen, Ditan Huayu based, Fang Codonopsis sweet nature into Insufficiency classics, spleen and lung, blood and fluid, blood deficiency; sweet wet hepatic Angelica Heart classics, blood to regulate menstruation, Huoxuezhitong, laxative; Rehmannia sweet and tepid owned by the liver and spleen, nourishing yin, essence and fill the marrow; medlar sweet nature normalized lung and kidney, nourishing the liver and kidney, lungs and eyesight; Eucommia sweet and warm into the The liver and kidney, liver or kidney strong bones; Salvia bitter and slightly cold heartless go through, blood to regulate menstruation, blood eliminate pain; Shichangpu spicy tepid into the heart through the liver and spleen, resuscitation Phlegm, qi and blood chills; Chuanxiong spicy tepid into the gallbladder through the gas line Gloomy, expelling dampness, Huoxuezhitong; Astragalus sweet and tepid into Insufficiency classics, fill in the spleen, Sun cite depression, Yi Wei solid form diuretic; Yizhiren spicy and warm Guishen spleen, kidney Gujing reduction of urine warm, warm the spleen appetizer; walnuts sweet and warm heat into the kidney lung, kidney tonic, warm the lung and intestines official Yin; far Le Pungent and warm normalized kidneys lung, nerves s2 arriving in , expectorant resuscitation, dissipate carbuncles; bile Southern Star gung bitter slightly acrid and cool normalized Qiu gall bladder, phlegm, Xifeng be scared; Cistanche sweet tepid Guishen colon, Bushenyijing moistening Hua Chang; acacia Jiao taste Gan Jian Ping owned by darling, stagnation nerves, blood carbuncle, continued bones; Radix sweet and bitter heart lungs stomach, clearing the lungs and stomach Chufan; Ligustrum taste joys of cool normalized by the liver and kidney, nourishing the liver kidney, Ukraine shall eyesight, Qingxudong heat; Radish Weixin Gan Xing into the stomach through, digestion in addition to inflation, lower gas phlegm; potato meat into the liver and kidney acidic tepid cup, liver and kidney tonic? grab grabbing solid vortex, liver Renal losses; rabbit wire sweet Sim natured charge kidney spleen, Bushenyijing? Liver eyesight; Gualou sweet bitter cold normalization stomach large intestine, heat expectorant, Chest relieves congestion; Polygonum sweet After normalization of tepid astringent kidney, liver or kidney essence and blood, Gushen Ukraine must; Curcuma Bitterpungent owned by the liver and spleen, expelling gas line, consumer product analgesic; peach bitter freewill large intestine through the liver, blood expectorant, laxative; Sang cuttlebone sweet and salty Pinggan classics, kidney yang, solid minified urinary Indications kidney yang decline.

More than all medicines share, the blood stasis dispelling of can kidney and spleen invigorating eliminating the phlegm, being used to treat alzheimer disease has good curative effect.No Western medicine prepn is to side effect such as human internal organ infringements.

For further investigating the clinical efficacy and the safety of medicine of the present invention, select 136 routine alzheimer disease patients that the curative effect of medicine of the present invention is carried out clinical observation.

For using the treatment statistical conditions of the present invention to 136 routine alzheimer disease patients, curative effect is following after 1-2 course of therapy below:

1, cures (cardinal symptom disappears basically, and look clear-headed, and directed sound, answer is correct, is quick on the draw, and life can be taken care of oneself, and can participate in the mass society activity) 79 examples, account for 58%;

2, effectively (cardinal symptom partly disappears and alleviates, and life can be taken care of oneself basically, and answer is in the main true, but bradykinesia, intelligence still has partial impairment) 51 examples, account for 38%;

3, invalid (cardinal symptom does not have improvement, and life can not be handled) 6 examples account for 4%.

The present invention has no side effect and untoward reaction.

The specific embodiment

Embodiment: get Radix Codonopsis 30kg, Radix Angelicae Sinensis 25kg, Radix Rehmanniae Preparata 20kg, Fructus Lycii 20kg, Cortex Eucommiae 20kg, Radix Salviae Miltiorrhizae 25kg, Rhizoma Acori Graminei 15kg, Rhizoma Chuanxiong 15kg, Radix Astragali 30kg, Fructus Alpiniae Oxyphyllae 25kg, semen juglandis 20kg, Radix Polygalae 20kg, Arisaema Cum Bile 15kg, Herba Cistanches 15kg, Cortex Albiziae 15kg, Radix Ophiopogonis 25kg, Fructus Ligustri Lucidi 20kg, Radix Paeoniae Alba 20kg, Semen Raphani 15kg, Fructus Corni 25kg, Semen Cuscutae 25kg, Fructus Trichosanthis 15kg, Radix Polygoni Multiflori 20kg, Rhizoma Curcumae 15kg, Semen Persicae 15kg, Ootheca Mantidis 15kg, clean, add two times of weight parts waters and decoct 3 times with clear water; Each 20 minutes; Collecting decoction filters, and filtrating is condensed into the clear paste of 70 ℃ of relative densities 1.15～1.18; Cold preservation is left standstill; Get supernatant and filter, add conventional adjuvant, mixing in the filtrating; Adding purified water is 1g/ml to containing the crude drug amount, and oral liquid formulations is processed in embedding, sterilization.

Advantage of the present invention and effect:

1, medicine time short treating period, curative effect is long, effect is fast;

2, take this side's medicine, clothes are fried in shallow oil certainly certainly, and are convenient and swift;

3, spend to lack, curative effect is high, and the common people can accept, and does not have bounce-back, does not have and recurs.

Claims

1. medicine of treating alzheimer disease is characterized in that:

Medicine according to the invention is that feedstock production obtains by following parts by weight of traditional Chinese medicines:

Fructus Lycii 30-40 Cortex Eucommiae 25-35 Radix Salviae Miltiorrhizae 25-35

Rhizoma Acori Graminei 15-25 Rhizoma Chuanxiong 20-30 Radix Astragali 30-40

Fructus Alpiniae Oxyphyllae 25-35 semen juglandis 25-35 Radix Polygalae 25-35

Arisaema Cum Bile 15-25 Herba Cistanches 15-25 Cortex Albiziae 15-25

Semen Raphani 15-25 Fructus Corni 20-30 Semen Cuscutae 20-30

Semen Persicae 15-25 Ootheca Mantidis 15-25.

2. the medicine of treatment alzheimer disease according to claim 1, its characteristic is being that described medicine is processed oral liquid.

3. the method for preparing of the medicine of the described treatment alzheimer disease of claim 2 is: above-mentioned medicaments in part by weight is cleaned up the back mix homogeneously, add two times of weight parts waters, decoct each 20 minutes 2～4 times; Collecting decoction filters, and filtrating is condensed into the clear paste of 70 ℃ of relative densities 1.15～1.18; Cold preservation is left standstill, and gets supernatant and filters, and adds conventional adjuvant in the filtrating; Mixing, adding purified water is 1g/ml to containing the crude drug amount, oral liquid formulations is processed in embedding, sterilization.