CN102772777B - Medicine for treating infantile pneumonia and preparation method thereof - Google Patents

Abstract

The invention discloses a medicine for treating infantile pneumonia and a preparation method thereof. The medicine is mainly prepared from ginseng, honeysuckle, radix salviae miltiorrhizae, bamboo leaf, prepared radix licorice, rhizoma zingiberis, fructus forsythiae and monkshood which are proportioned according to a certain weight ratio, the medicine disclosed by the invention has excellent effect on the symptoms of eupyrexia or hectic fever, obvious asthma and slight sweating or hypohidrosis, and the medicine has quick-acting treatment effect on infantile pneumonia without relapse and the treatment course is short.

Description

A kind of medicine for the treatment of infantile pneumonia and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of infantile pneumonia and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Infantile pneumonia is common clinical, and the four seasons all easily occur, and take winter-spring season as many.As not thorough in treatment, easily outbreak repeatedly, affects child and grows.At present, the Therapeutic Principle of pneumonia is application anti-inflammation drugs, kills pathogen.According to different pathogen, select responsive medicine, to severe pneumonia, should to hospital, carry out corresponding hospitalization in time.Children's too much takes antiinflammatory antibiotic medicine, and side effect is large, and therefore, people exist very large demand to the Chinese medicine of effective treatment infantile pneumonia.

Summary of the invention

The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the medicine of effective treatment infantile pneumonia, thereby has completed the present invention.

Object of the present invention is just to provide a kind of composition of medicine that can treat infantile pneumonia.

Another object of the present invention has just been to provide the preparation method of this composition of medicine.

Medicine of the present invention selects Radix Ginseng, Flos Lonicerae, Radix Salviae Miltiorrhizae, Folium Bambusae, Gypsum Fibrosum, Radix Ophiopogonis, the Rhizoma Pinelliae, Radix Glycyrrhizae Preparata, Rhizoma Zingiberis, Fructus Forsythiae, Radix Trichosanthis, Radix Angelicae Sinensis and Radix Aconiti Lateralis Preparata medicine to combine, make each efficacy of drugs produce synergism these drug regimens, thus recurrence that can fast treating infantile pneumonia.Wherein select Radix Ginseng to be because its nature and flavor are sweet micro-sweet, temperature, enters spleen, lung meridian, has strongly invigorating primordial QI, Gu de-, promote the production of body fluid, the function of calming the nerves, controls impairment caused by overstrain deficient, lack of appetite, asthenia, food is told in regurgitation, stool lingering diarrhea, empty cough with asthma is short, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition, quenches one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency are not multiple, the disease of all qi-blood-body fluid deficiencies.Select Flos Lonicerae to be because its nature and flavor are sweet, cold, enter lung, stomach warp, there is heat clearing away, the function of removing toxic substances, controls epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.Select Radix Salviae Miltiorrhizae to be because its nature and flavor are bitter, tepor, enters the heart, Liver Channel, has blood circulation and promoting silt, calming heart and tranquilizing mind, and evacuation of pus, the function of pain relieving, controls angina cordis, menoxenia, dysmenorrhea, to close, metrorrhagia leukorrhagia ， mass in the abdomen, gathers, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling.Select Folium Bambusae to be because its property slightly sweet flavor is cold, enter the heart, lung, gallbladder, stomach warp, have clearing heat and relieving fidgetness, the function of the diuresis of promoting the production of body fluid, controls calentura excessive thirst, and little youngster shies Epilepsy, and cough with dyspnea is told nosebleed, flushed complexion, oliguria with reddish urine, erosion of the oral mucosa tongue boil.Select Gypsum Fibrosum to be because its property acrid-sweet flavor is cold, enter lung, stomach warp, raw with there being expelling pathogenic factors from muscles for clearing heat, the function that relieving restlessness is quenched the thirst, controls calentura high fever and does not move back, vexed coma, delirium is gone mad, thirsty and dry pharynx, lung-heat dyspnea with rapid respiration, heatstroke spontaneous perspiration, stomach-fire headache, toothache, hyperactivity of toxic heat, send out speckle dermexanthesis, aphtha of the mouth and tongue, forges deposited promoting tissue regeneration and ulcer healing, external treatment ulcer sores, bursts and does not regain, the burning hot wound of soup.Select be Radix Ophiopogonis because its property sweet and slightly bitter taste is cold, enter lung, stomach, heart channel, have nourishing YIN and moistening the lung, the relieving restlessness that clears away heart-fire, the function of reinforcing stomach reg fluid, controls dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung abscess, asthenia dysphoria with smothery sensation, thirsty clearly, calentura Tianjin wound, dry mouth and throat, constipation.Select the Rhizoma Pinelliae to be because its nature and flavor are pungent, temperature, poisonous, enter spleen, stomach warp, there is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the function of dissolving lump and resolving mass, controls damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm headache, dizzy sleeplessness, outer subduing inflammation.Select Radix Glycyrrhizae to be because its nature and flavor are sweet, flat, enter spleen, stomach, lung meridian, there are and middle emergency lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription; Process use, control taste lack of appetite, stomachache loose stool, overstrain heating, consumptive lung disease cough, cardiopalmus ， Jing Epilepsy; Raw use, controls laryngopharynx swelling and pain, peptic ulcer, and carbuncle subcutaneous ulcer skin infection, separates poison of drug and alimentary toxicosis.Select Rhizoma Zingiberis to be because its nature and flavor are pungent, heat, enters spleen, stomach, lung meridian, has warming middle-JIAO by cold, and the function that recuperating depleted YANG is promoted blood circulation, controls trusted subordinate's cold type of pain, vomit and diarrhoea, and cold extremities faint pulse, cold fluid-retention is breathed with cough, anemofrigid-damp arthralgia, yang deficiency is told, nosebleed, hematochezia.Select Fructus Forsythiae to be because its nature and flavor are bitter, cool, enter the heart, liver, gallbladder meridian, have heat clearing away, removing toxic substances, eliminating stagnation, the function of detumescence, control warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.Select Radix Trichosanthis to be because its nature and flavor sweetness and bitterness acid is cool, enter lung, stomach warp, have and promote the production of body fluid, quench the thirst, pathogenic fire reducing, moisturizes, evacuation of pus, and the function of detumescence, controls calentura thirsty, quenches one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid complicated by anal fistula.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm enters the heart, liver, spleen channel, have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, the function of moisturizing laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Selecting Radix Aconiti Lateralis Preparata is because of its property acrid-sweet flavor, and heat is poisonous, enter the heart, spleen, kidney channel, have recuperating depleted YANG to mend fire, the function of dispelling cold and removing dampness, control excessive YIN keeping YANG externally, loss of YANG due to profuse perspiration, vomiting and diarrhea is fainted contrary, trusted subordinate's cold type of pain, the splenic diarrhea cold-dysentery, beriberi edema, children's's intermittent infantile convulsion, the contracture of anemofrigid-damp arthralgia ， Wei lame, the disease of the leakage of carbuncle of yin nature skin ulcer and all chronic diseaseses.

The specific embodiment

The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Radix Ginseng 5-13 gram of Flos Lonicerae 8-20 gram of Radix Salviae Miltiorrhizae 8-14 gram

Folium Bambusae 1-5 gram Gypsum Fibrosum 4-18 gram Radix Ophiopogonis 2-8 gram

Rhizoma Pinelliae 3-10 gram of Radix Glycyrrhizae Preparata 1-5 gram of Rhizoma Zingiberis 2-6 gram

Fructus Forsythiae 10-20 gram of Radix Trichosanthis 12-23 gram of Radix Angelicae Sinensis 5-15 gram

Radix Aconiti Lateralis Preparata 5-15 gram

Wherein, be preferably

10 grams of 15 grams of Radix Salviae Miltiorrhizaes of 10 grams of Flos Loniceraes of Radix Ginseng

4.5 grams of 3 grams of Gypsum Fibrosum of Folium Bambusae 9 grams of Radix Ophiopogonis

3 grams of 3 grams of Rhizoma Zingiberiss of 4.5 grams of Radix Glycyrrhizae Preparatas of the Rhizoma Pinelliae

10 grams of 15 grams of Radix Angelicae Sinensis of 15 grams of Radix Trichosanthis of Fructus Forsythiae

10 grams of Radix Aconiti Lateralis Preparatas

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Radix Ginseng: except removing LU, cutting;

2, Flos Lonicerae: sieve removes silt, chooses clean impurity;

3, Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;

4, Folium Bambusae: choose clean impurity, except destemming leaf, dry;

5, Gypsum Fibrosum: remove assorted stone, clean earth, be broken into fritter;

6, Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, pump the heart after running through, then clean and dry;

7, the Rhizoma Pinelliae: choose decontamination, sieve dedust bits;

8, Radix Glycyrrhizae Preparata: extracting liquorice sheet add cooked Mel and boiled water a little, mix thoroughly, slightly vexed, put in pot and fry to becoming buff with slow fire, tack-free till, taking-up cools, 100 jin, every Radix Glycyrrhizae, with refined honey 25-30 jin;

9, Rhizoma Zingiberis: choose clean impurity, be soaked in water 3-6 hours, pull out, cut into slices after moistening or dice, dry;

10, Fructus Forsythiae: choose clean impurity, stranding is opened, except discarding stalk;

11, Radix Trichosanthis: choose decontamination, size block separately, saturating with blister approximately sixty percent, pulls out, and moistening is even to inside and outside humidity, and section, dries, or wash, and pulls out, shines extremely dryly, smashes into fritter;

12, Radix Angelicae Sinensis: choose roguing and sanction, clean, moistening, slightly dries in the air when suitable to inside and outside humidity, and section is dried;

13, Radix Aconiti Lateralis Preparata: be soaked in water, pull out, section, dries.

Two, preparation

1, the Radix Ginseng of described weight, Flos Lonicerae, Radix Salviae Miltiorrhizae, Folium Bambusae, Gypsum Fibrosum, Radix Ophiopogonis, the Rhizoma Pinelliae, Radix Glycyrrhizae Preparata, Rhizoma Zingiberis, Fructus Forsythiae, Radix Trichosanthis, Radix Angelicae Sinensis, Radix Aconiti Lateralis Preparata being added to four times of amounts of water soaks, first with little fire, decoct 20 minutes, intense fire decocts boiling, use again slow fire boiling 15 minutes, obtain decoction liquor for the first time.

2, will filter for the first time rear medicinal residues and add water qdx, and decoct boiling, then within 10 minutes, obtain decoction liquor for the second time with slow fire boiling.

3, twice decoction liquor mixed, medicinal liquid is divided into 2 doses.

Medicine of the present invention has heat clearing away, removing toxic substances, and eliminating stagnation, the function of detumescence, treatment infantile pneumonia instant effect, short treating period, do not recur.While taking, avoid cold and uncooked food, the thing of pungent, polysaccharide.

By test example, further set forth below the beneficial effect of medicine of the present invention, these tests comprise animal toxicity test and the clinical observation test of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention:

Get 30 of rabbit, male and female dual-purpose, body weight 2.0-2.5kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day twice, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention:

1, physical data:

Accept out-patient's 190 examples for medical treatment, light-duty class 135 examples wherein, heavy class 55 examples.

2, diagnostic criteria:

Light-duty parapneumonia: start as irritating property dry cough frequently, rale sound appears in bottleneck throat thereupon, can be with vomiting, the milk of choking during cough.Hypopnea speeds, and infant is with lethargy, dysphoria, and inappetence, trembles, diarrhoea waits General Symptoms.

Heavy parapneumonia: Respiratory symptoms: hypopnea, rapid, per minute reaching more than 80 times, flaring of alaenasi, Expiratory sigh, the obvious cyanosis of facial area and limb end, very person's pale complexion or steel gray.

3, Therapeutic Method

Select above-mentioned medicament, to pediatric patient, take, 2 doses of 2 years old above every days, every dose minute 2 times clothes; 1 dose of every day in 1-2 year, every dose minute 4 times clothes.Within 7 days, be a course for the treatment of, light-duty parapneumonia is taken two courses for the treatment of continuously, and heavy parapneumonia contact is taken four courses for the treatment of.

4, efficacy assessment standard

Effective: clinical symptom disappearance after treatment, it is normal that body constitution is recovered, and observes half a year without recidivist;

Take a turn for the better: clinical symptoms is obviously improved, and body constitution is progressively recovered;

Invalid: clinical partial symptoms disappears or without change, do not reach improvement standard person.

5, therapeutic outcome

In above-mentioned treatment, by Drug therapy infantile pneumonia patient of the present invention 190 examples, light-duty parapneumonia 135 examples wherein, effective 130 examples of the light-duty parapneumonia of result, obvious effective rate is 96.3%, 4 examples that take a turn for the better, improvement rate is 2.96%, invalid 1 example, total effective rate is 99.26%.Treat heavy parapneumonia 55 examples, effective 52 examples of heavy parapneumonia, obvious effective rate is 94.55%, 1 example that takes a turn for the better, improvement rate is 1.82%, invalid 2 examples, total effective rate is 96.37%.

Claims (3)

1. a medicine for the treatment of infantile pneumonia, is characterized in that: it is to be made by the crude drug within the scope of following weight:

Radix Ginseng 5-13 gram of Flos Lonicerae 8-20 gram of Radix Salviae Miltiorrhizae 8-14 gram

Folium Bambusae 1-5 gram Gypsum Fibrosum 4-18 gram Radix Ophiopogonis 2-8 gram

Rhizoma Pinelliae 3-10 gram of Radix Glycyrrhizae Preparata 1-5 gram of Rhizoma Zingiberis 2-6 gram

Fructus Forsythiae 10-20 gram of Radix Trichosanthis 12-23 gram of Radix Angelicae Sinensis 5-15 gram

Radix Aconiti Lateralis Preparata 5-15 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

10 grams of 15 grams of Radix Salviae Miltiorrhizaes of 10 grams of Flos Loniceraes of Radix Ginseng

4.5 grams of 3 grams of Gypsum Fibrosum of Folium Bambusae 9 grams of Radix Ophiopogonis

3 grams of 3 grams of Rhizoma Zingiberiss of 4.5 grams of Radix Glycyrrhizae Preparatas of the Rhizoma Pinelliae

10 grams of 15 grams of Radix Angelicae Sinensis of 15 grams of Radix Trichosanthis of Fructus Forsythiae

10 grams of Radix Aconiti Lateralis Preparatas.

3. according to the preparation method of medicine described in claim 1 or 2, it is characterized in that: it comprises the following steps:

(1) get the raw materials ready

(1) Radix Ginseng: except removing LU, cutting;

(2) Flos Lonicerae: sieve removes silt, chooses clean impurity;

(3) Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;

(4) Folium Bambusae: choose clean impurity, except destemming leaf, dry;

(5) Gypsum Fibrosum: remove assorted stone, clean earth, be broken into fritter;

(6) Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, pump the heart after running through, then clean and dry;

(7) Rhizoma Pinelliae: choose decontamination, sieve dedust bits;

(8) Radix Glycyrrhizae Preparata: extracting liquorice sheet add cooked Mel and boiled water a little, mix thoroughly, slightly vexed, put in pot and fry to becoming buff with slow fire, tack-free till, taking-up cools, 100 jin, every Radix Glycyrrhizae, with refined honey 25-30 jin;

(9) Rhizoma Zingiberis: choose clean impurity, be soaked in water 3-6 hours, pull out, cut into slices after moistening or dice, dry;

(10) Fructus Forsythiae: choose clean impurity, stranding is opened, except discarding stalk;

(11) Radix Trichosanthis: choose decontamination, size block separately, saturating with blister approximately sixty percent, pulls out, and moistening is even to inside and outside humidity, and section, dries, or wash, and pulls out, shines extremely dryly, smashes into fritter;

(12) Radix Angelicae Sinensis: choose decontamination, clean, moistening, slightly dries in the air when suitable to inside and outside humidity, and section is dried;

(13) Radix Aconiti Lateralis Preparata: be soaked in water, pull out, section, dries;

(2) preparation

(1) Radix Ginseng of described weight, Flos Lonicerae, Radix Salviae Miltiorrhizae, Folium Bambusae, Gypsum Fibrosum, Radix Ophiopogonis, the Rhizoma Pinelliae, Radix Glycyrrhizae Preparata, Rhizoma Zingiberis, Fructus Forsythiae, Radix Trichosanthis, Radix Angelicae Sinensis, Radix Aconiti Lateralis Preparata being added to four times of amounts of water soaks, first with little fire, decoct 20 minutes, intense fire decocts boiling, use again slow fire boiling 15 minutes, obtain decoction liquor for the first time;

(2) will filter for the first time rear medicinal residues and add water qdx, and decoct boiling, then within 10 minutes, obtain decoction liquor for the second time with slow fire boiling;

(3) twice decoction liquor mixed, medicinal liquid is divided into 2 doses.