CN102764408B - Dealcoholic preparation - Google Patents
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- CN102764408B CN102764408B CN201210015234.4A CN201210015234A CN102764408B CN 102764408 B CN102764408 B CN 102764408B CN 201210015234 A CN201210015234 A CN 201210015234A CN 102764408 B CN102764408 B CN 102764408B
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Abstract
The invention relates to a dealcoholic preparation, specifically to a dealcoholic preparation which can make drinkers get rid of symptoms of headache and nausea and make them recover in a short period of time. The dealcoholic preparation is characterized by comprising the following substances of: 400-800 mg of lactose, 80-300 mg of starch, 50-150 mg of maltose, 50-100 mg of turmeric powder, 10-20 mg of curcumin, 100-250 mg of inositol, 30-70 mg of citric acid, 10-40 mg of nicotinic acid, 50-150 mg of vitamin C, 4-8 mg of vitamin E, 5-15 mg of vitamin B6, 30-70 mg of flavouring composition and 50-250 mg of a flavouring agent. In comparison with the prior art, the dealcoholic preparation can be taken to make drinkers rapidly get rid of symptoms of headache and nausea and make them recover in a short period of time, and has an effect of protecting liver.
Description
[technical field]
The present invention relates to a kind of sobering preparation, a kind of alcohol user of making breaks away from headache very soon specifically, nauseating symptom, and the sobering preparation that can recover in the short period of time.
[background technology]
Spirits culture is as a kind of special form of culture, especially unique status in traditional Chinese culture.In the civilized history of several thousand, wine is almost penetrated into the every field in society.Then acutely drink and can cause nausea, vomiting, absent minded, liver cell is impaired, and emotional instability can cause lethargy when serious, stupor, circulatory function dies of exhaustion and dies.Drink for a long time and can cause digestion, nerve, the many pathological changes of system such as circulation.Ethanol has minute quantity in vivo directly through urine, and antiperspirant or lung excrete, and most ethanol, mainly at liver metabolism, is converted into acetaldehyde through ethanol dehydrogenase by ethanol, then is oxidized to acetic acid through liver aldehyde dehydrogenase, finally becomes water and carbon dioxide excretes.Long-term heavy drinking, can cause alcoholic liver disease, alcoholic encephalopathy, brain atrophy, alcoholic dementia, Alcoholic osteopathia, the loose and femur head necrosis of sclerotin, also can cause alcoholic cardiomyopathy, prevalence and the case fatality rate of coronary heart disease are increased, impotence, pregnancy period infant development defect.
Rhizoma Curcumae Longae (Curcuma longa Linn) derives from the dry rhizome of plant Rhizoma Curcumae Longae, has the effect of removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia, and Chinese Traditional Medicine is used for the treatment of the multiple diseases such as the twinge of the breast side of body, rheumatism shoulder arm pain, treating swelling and pain by traumatic injury, amenorrhea, leprosy abdominal mass.The chemical composition of Rhizoma Curcumae Longae is mainly curcumin and Rhizoma Curcumae Longae volatile oil, and curcumin is mainly containing curcumin (curcumin), demethoxycurcumin (demefhoxvcurcumin) and bisdemethoxycurcumin (bisdemefhoxycurcumin).Wherein curcumin is the most important chemical composition of Rhizoma Curcumae Longae performance pharmacological action, has pharmacological action widely and the important economic worths such as antiinflammatory, antioxidation, antitumor, protection hepatic and renal function.
Rhizoma Curcumae Longae is because plucking time difference can be divided into spring Rhizoma Curcumae Longae, autumn Rhizoma Curcumae Longae and purple Rhizoma Curcumae Longae (summer Rhizoma Curcumae Longae).Spring Rhizoma Curcumae Longae and purple Rhizoma Curcumae Longae take Rhizoma Curcumae Longae essential oil as Main Ingredients and Appearance, autumn Rhizoma Curcumae Longae is in the majority with curcumin (curcumin).
In Japan, with autumn Rhizoma Curcumae Longae, relieve the effect of alcohol and have the history of centuries, the autumn Rhizoma Curcumae Longae of wherein producing with area, Okinawa is the most famous.The functions such as its folk remedy confirms, autumn Rhizoma Curcumae Longae has nourishing the liver, protects stomach, solution is still drank after a night, can eliminate the liver function that causes because drinking lowly, have a headache after drinking, the discomfort of vomiting, chest and stomach and inappetence etc. are not suitable with symptom.
The special bitterness of Rhizoma Curcumae Longae affects it and is widely used, and in order to reduce bad mouthfeel and to improve the content of effective ingredient curcumin, Japanese Ryukyu agricultural college of university develops the patented technology of Rhizoma Curcumae Longae fermentation technology.At present, domestic existing fermentation Rhizoma Curcumae Longae (wherein curcumin content is 60%) Ji Duojia curcumin manufacturer.
Antialcoholic drug totally can be divided into three kinds of chemical drugss, Chinese medicine preparation, health product.
Chemical drugs: be mostly the compositions such as analeptic, vitamin and aminoacid, can play fast relieve the effect of alcohol, sobering-up functions, but most chemical drugs relieving mechanism is only to promote ethanol to decompose, and plays temporary mitigation, is difficult to play liver protection effect.As the RU21 of KGB antialcoholic drug, the powerful Soboring-up liver-protecting ball of companion of wine, the kind such as wine is bottomless.
Chinese medicine preparation: composition mostly is Japanese raisintree fruit, flower of Radix Puerariae, the Radix Paeoniae Alba, Semen Myristicae, these Chinese medicines can play fine relieving the effect of alcohol and the effect of whole body conditioning, but effect is slow a little.Be free from side effects, at Dealcoholic sobering-up, also liver and gall diseases had to good curative effect simultaneously.As: relieving alcoholism and protecting the liver ball, relieving alcoholic intoxication king sheet, the Chinese medicine preparation such as flower of Radix Puerariae, Fructus Tsaoko, Rhizoma Alpiniae Officinarum, Flos Chrysanthemi, Caulis Bambusae In Taenia, Radix Sophorae Flavescentis, Semen Myristicae also can finely relieve the effect of alcohol.
Health product: the health product of the relieving alcoholism and protecting the liver of selling on market are now a lot, should say that these effects are limited.Relieving alcoholism and protecting the liver medicine mostly is Chinese patent medicine, and composition is Flos puerariae lobatae, Radix Puerariae, the Radix Paeoniae Alba, Radix Bupleuri, Semen Hoveniae (Fructus Hoveniae), Fructus Mori and rich selenium wild camellia etc., and these Chinese medicines truly have relieving alcoholism and protecting the liver effect.It should be noted that somebody is deficiency of liver-YIN, somebody is hot-tempered, and medication effect is just different.Also have part producer to add diuretic, analeptic, hormone etc. inside at antialcoholic drug, these compositions people eaten in the later short time can feel to regain consciousness, excited, appetite holds greatly, but long-term taking will injure health.As: wine calabash, extra large Wang Jin cup, strong Lingshui Spring threose, wine younger sister relieving alcoholic intoxication buccal tablet etc.Three kinds of antialcoholic drugs all do not include successfully, but disintoxicating product sales volume is whole decline in the situation that, and the fermentation curcumin of take of Japan is that the sales volume that main imperial wine ball and wine gulp down team is all the steady liter that has, and imperial wine ball has entered the ranks of first three especially.
[summary of the invention]
The present invention, in order to overcome the deficiencies in the prior art, provides a kind of and has felt sick to dizzy after drinking, and frequent micturition etc. have the Medicament for Alcoholism of good result.
To achieve these goals, the present invention has designed a kind of sobering preparation, it is characterized in that: by following material, be prepared from, lactose 400-800mg, starch 80-300mg, maltose 50-150mg, sucrose 50-250mg, curcuma powder 50-100mg, curcumin 10-20mg, inositol 100-250mg, citric acid 30-70mg, nicotinic acid 10-40mg, vitamin C 50-150mg, vitamin E 4-8mg, vitamin B6 5-15mg, edible essence 30-70mg, correctives 50-250mg.
Described sobering preparation adopts following processing step;
A) by starch 80-300mg, lactose 400-800mg adds purified water 1000-2000ml, stirs, and is heated to 100 ℃;
B) get fermentation curcumin 10-20mg, curcuma powder 50-100mg, sucrose 50-250mg, vitamin C 50-150mg, vitamin E 4-8mg, vitamin B6 5-15mg, inositol 100-250mg, citric acid 30-70mg, nicotinic acid 10-40mg, edible essence 30-70mg, maltose 50-150mg evenly mixes;
C) will in the mixture in step B, add the purified water of 1000-2000ml and evenly mix;
D) mixture in steps A is carried out cooling, the mixture obtaining after cooling evenly mixes with the mixture in step C;
E) mixture obtaining in step 4 is first divided and is filled to every bag of 200ml, then autoclaving, is finished product.
Described sobering preparation is used for making capsule, tablet, granule, oral liquid and beverage.
The present invention compared with the existing technology, is to take curcumin as primary raw material, and with pharmaceutically acceptable adjuvant, can be made into capsule, tablet, granule, oral liquid or beverage.After taking, can make alcohol user break away from very soon headache, nauseating symptom, and can recover in the short period of time, and there is the effect of hepatoprotective.
[specific embodiment]
Below in conjunction with embodiment, the invention will be further described.
Embodiment mono-:
The present invention includes above-mentioned raw materials forms according to weight configuration:
A) by starch 300mg, lactose 800mg adds purified water 1000ml, stirs, and is heated to 100 ℃.
B) get fermentation curcumin 20mg, curcuma powder 100mg, sucrose 100mg, vitamin C 100mg, vitamin E 5mg, vitamin B6 10mg, inositol 250mg, citric acid 70mg, nicotinic acid 20mg, edible essence 50mg, maltose 100mg evenly mixes.
C) will in the mixture in step B, add the purified water of 1000-2000ml and evenly mix;
D) mixture in steps A is carried out cooling, the mixture obtaining after cooling evenly mixes with the mixture in step C;
E) mixture obtaining in step 4 is first divided and is filled to every bag of 200ml, then autoclaving, is finished product.
Embodiment bis-:
The present invention includes above-mentioned raw materials forms according to weight configuration:
A) by starch 200mg, lactose 600mg adds purified water 1000ml, stirs, and is heated to 100 ℃.
B) get fermentation curcumin 20mg, curcuma powder 80mg, sucrose 80mg, vitamin C 80mg, vitamin E 4mg, vitamin B6 8mg, inositol 200mg, citric acid 60mg, nicotinic acid 15mg, edible essence 40mg, maltose 80mg evenly mixes.
C) will in the mixture in step B, add the purified water of 1000-2000ml and evenly mix;
D) mixture in steps A is carried out cooling, the mixture obtaining after cooling evenly mixes with the mixture in step C;
E) mixture obtaining in step 4 is first divided and is filled to every bag of 200ml, then autoclaving, is finished product.
Embodiment tri-:
The present invention includes above-mentioned raw materials forms according to weight configuration:
A) by starch 100mg, lactose 400mg adds purified water 1000ml, stirs, and is heated to 100 ℃.
B) get fermentation curcumin 15mg, curcuma powder 50mg, sucrose 60mg, vitamin C 70mg, vitamin E 4mg, vitamin B6 6mg, inositol 180mg, citric acid 50mg, nicotinic acid 12mg, edible essence 30mg, maltose 80mg evenly mixes.
C) will in the mixture in step B, add the purified water of 1000-2000ml and evenly mix;
D) mixture in steps A is carried out cooling, the mixture obtaining after cooling evenly mixes with the mixture in step C;
E) mixture obtaining in step 4 is first divided and is filled to every bag of 200ml, then autoclaving, is finished product.
The present invention is used as disintegrating agent by starch, and disintegrating agent is to make tablet in gastro-intestinal Fluid, split rapidly the material that is broken into fine particle, except slow (control) releases the tablet of sheet and some specific use, in general tablet, all should add disintegrating agent.Because they have very strong water swellability, can disintegrate the adhesion of tablet, make tablet split and be broken into many tiny granules from a whole tablet, realize the disintegrate of tablet, so be extremely conducive to dissolving and the absorption of principal agent in tablet.Dried starch is most preferred disintegrating agent, water content is below 8%, water absorption is strong and have certain dilatancy, be applicable to the tablet of water-insoluble or microsolubility medicine, but the disintegration to soluble drug is poor, this is to produce concentration difference because soluble drug is met water dissolution, makes the difficult inside that penetrates into tablet by solution aspect of water of tablet outside, has hindered the imbibition of tablet internal starch.Aborning, the general disintegrate effect that adopts outer addition, interior addition or inside and outside addition to reach expection.
The present invention adopts curcuma powder and curcumin as principal agent, and the Main Function of its Rhizoma Curcumae Longae is:
1, effect for reducing blood fat curcumol or ether extract, curcumin and volatile oil gavage, experimental atherosclerosis rats and rabbit are had to the effect of significantly falling total plasma cholesterol and B-lipoprotein, and can reduce liver cholesterol, correct a-and B-lipoprotein out of proportion, but on endogenous cholesterol without impact; More remarkable to falling the effect of plasma triglyceride, can make triglyceride in blood plasma be reduced to below normal level.Effect of high sucrose food can cause that rat produces hyperlipemia, and curcumin can resist this hyperlipemia and produce.It is heavy that gavage curcumin can reduce liver, reduce triglyceride, free fatty, content of phospholipid and the total triglyceride of serum, VLDL+LDL triglyceride in liver, the content of HDL triglyceride, VLDL+LDL cholesterol and blood free fatty acid, also can improve serum total cholesterol and HDL cholesterol level.With the external thermal-insulating method of liver homogenate, take 14C-acetic acid as substrate test, PRELIMINARY RESULTS shows, curcumin can suppress the synthetic of fatty acid.
2, antitumor action, carries out tissue culture and tests at body with Mus DaltonShi lymphoid ascites oncocyte, the growth of curcumol extract energy anticancer.When 0.4mg/ml, can suppress Chinese hamster ovary cell growth, and lymphocyte and DaltonShi lymphocyte are had to cytotoxic effect, and can reduce the growth of animal tumor, its active component is mainly curcumin.Under Oleum Tiglii promotes, 7,12-DMBA can bring out mice and produce papillary carcinoma, and curcumin can obviously reduce the chance that papillary carcinoma produces in the case, also can suppress to be formed by the tumor of 2O-methyl chrloroanthracene induction.Curcumin can also reduce the carcinogenic probability of Mutagen.Curcumin can also suppress TPA(12-O-Tetradecanoylphorbol-13-acetate) Carcinogenesis.When topical application 10 μ mol/L curcumin, the suppression ratio of the guanyl decarboxylase being brought out by 5nmol/L TPA is reached to 91%; 10 curcumins of μ mol/L and the TPA-of 2nmol/L play topical application, and the suppression ratio in the chimeric epidermis DNA of entering of 3H-thymus pyrimidine that TPA is excited is 49%, and its suppression ratio is relevant with concentration.Therefore, usining curcumin can also be as a kind of anticarcinogen as principal agent.
3, antiinflammatory action, curcumin can resist the rat toe swelling that angle justice dish glue brings out, and have dose dependent, and dosage is when 60mg/kg, suppresses this antiinflammatory action within the scope of 30mg/kg.Curcumin sodium reversibly suppresses the isolated guinea pig ileum contraction that nicotine, acetylcholine, 5-hydroxy tryptamine, barium chloride and histamine bring out, and is similar to nonsteroidal anti inflammatory drugs.
4, resisting pathogenic microbes effect, in vitro tests, during one of curcumin percentage concentration, has inhibitory action to micrococcus (Micrococuspyogenesvar. Aureus).Volatile oil has powerful antifungic action.Rhizoma Curcumae Longae can extend the life span of virus inoculation mice.
5, on cardiovascular system without impact, curcumin intravenous injection has no significant effect blood pressure, the blood pressure that epinephrine, histamine and acetylcholine are caused also has no significant effect.By curcumin gavage, can resist Rat Ecg S-T, the variation of T ripple that pituitrin intravenous injection causes, gavage can also increase mice's myocardial nutritional blood flow.Curcumin has a significant effect to platelet aggregation and blood viscosity, and normal person's experiment in vitro curcumin concentration is 1 * 10
-4mol/L, remarkable anticoagulant, suppression ratio is 35.4%(P<0.01).After rat oral gavage 5 days, dosage is respectively 20,40,60,80mg/(kg days).Compare with matched group, platelet aggregation weakens, and plasma viscosity and whole blood viscosity reduce.Wherein with 40mg/(kg days) group anticoagulant effect is the strongest, suppression ratio is 34.6%(P<0.05).Continuing increases dosage, and inhibitory action has no the enhancing of carrying out property.Under low shear rate (37.5 seconds-1) condition, reduce blood and plasma viscosity effect remarkable, and during high shear rate (150 seconds-1), there was no significant difference.
6, choleretic effect, Rhizoma Curcumae Longae extract, curcumin, volatile oil, turmerone and zingiberene, Borneolum Syntheticum and sesquiterpenoid etc., have choleretic effect, and generation and the secretion of bile can be increased, and gallbladder contraction can be promoted, and the strongest with acting as of curcumin.
7, antioxidation, with organs such as NIH mouse brain, the heart, liver,kidney,spleens, make finite concentration homogenate, while being oxidized to lipid peroxide with unsaturated fatty acid, lipid peroxide is transformed into again malonaldehyde very soon, under heating condition, the principle of malonaldehyde and thiobarbituric acid reaction generation red compound detects, and result curcumin has obvious antagonism to the lipid peroxidation of five large internal organs.Each internal organs homogenate concentration is respectively, brain 3.39%, the heart 1.16%, liver (1) 3.97%, liver (2) 3.94%, kidney 2.08%, spleen 1.67%; Curcumin dosage (mg/100ml) is respectively, brain 0.31-0.123, heart 20.4-0.8, liver (1) 20.4-0.8, liver (2) 0.8-0.128, kidney 20.4-0.8, spleen 0.8-0.123, with blank comparison, except dosage 0.32, low dosage 0.123P>0.005 in spleen, outside brain high dose 0.32 P<0.01, all the other are P<0.001.
Experiment one:
A) rat peroral acute toxicity test
40 of SD rats, male and female half and half, stable raising three days, fasting 12h before administration, is diluted to respectively 1% solution with the dosage gavage of 2ml/100g by Chinese medicine stock solution with distilled water after weighing, and four hours repeat once, observe 30 days, experimental animal all occurs without untoward reaction such as diarrhoea and the phenomena of mortality.Sobering preparation LD510 of the present invention is greater than 20000mg/kg accordingly, according to food toxicity grading, belongs to avirulence.
B) its mouse oral administration pharmacological testing that relieves the effect of alcohol
8 weeks 60 of SD mices are divided into two groups (model control group, of the present invention group), male and female half and half, stable raising three days, fasting 12h before administration, after weighing, gavage gives 60% ethanol 15ml/kg respectively,, difference gastric infusion after 30 minutes, model group, with isopyknic distilled water gavage, is observed it and is righted disappearance and recovery situation.
Table one: for the Medicament for Alcoholism of compound turmeric element preparation rights and disappears and recovery situation the mice of drinking
| Group name | Right extinction time (minute) | Right the recovery time that disappears (minute) |
| Model control group | 28.5 | 180 |
| The present invention | 27 | 55.7 |
Experiment conclusion: experimental result shows that compound turmeric element preparation has obvious sober-up function.
Experiment two:
The personage after drinking that Medicament for Alcoholism of the present invention is applicable to any age bracket uses, the result of use analysis of data that following data are Medicament for Alcoholism of the present invention:
Take object: 350 persons of being still drank after a night, its age is in 25-35 year, 150 of men, 50 of female, carry out result of use analysis.
A) 200 experiencers first drink same brand Chinese liquor 200ml, use the compound turmeric element tablet that relieves the effect of alcohol after half an hour, take the Rhizoma Curcumae Longae sobering preparation 200ml making in embodiment 1.
B) another 150 experiencers first quote same brand Chinese liquor 200ml, are divided into three groups after after half an hour, Rhizoma Curcumae Longae sobering preparation 200ml, a certain producer in market that gives respectively to make in boiled water, embodiment two tablet that relieves the effect of alcohol.
Result contrast:
One, adopt own control, symptom variation before and after self medication, carries out paired observation.
Two, adopt grouping controlled trial, placebo is that boiled water, the compound turmeric element tablet person that is not still drank after a night of relieving the effect of alcohol of a certain producer of tablet and market of relieving the effect of alcohol uses simultaneously, carries out paired observation.
Curative effect judging standard:
Effective standard: the sign of being still drank after a night is obviously improved, it is normal that physical examination result is recovered substantially.
Effective standard: the sign of being still drank after a night is more obviously improved or alleviated, and it is normal that physical examination result is recovered substantially.
Invalid standard: the sign of being still drank after a night is without improvement, unchanged before and after medication.
Feedback result: have 120 people to feel for 10 minutes after taking the present invention and drug effect have 45 people to arrive drug effect at 20 minutes aftersensations, 35 people arrive drug effect at 30 minutes aftersensations.
Efficacy result: effective 175 examples, effective 17 examples, invalid 8 examples.
Grouping controlled trial:
Table two: be the impact of compound turmeric element preparation on the person's of being still drank after a night sign
| Group name | The sign of being still drank after a night recovery time (minute) |
| Placebo | 150 |
| The present invention | 26.5 |
| The sobering preparation of certain producer on the market | 43.7 |
For 350 experimenters chemical examination check before and after test, blood, routine urinalysis, liver function analysis is all without abnormal, and there is not other toxicities and untoward reaction in viewing duration, proves the direct safety non-toxic that relieves the effect of alcohol of the present invention.
From above-mentioned experimental data, can find out, sobering preparation of the present invention can make alcohol user break away from very soon headache after taking, nauseating symptom, and can recover in the short period of time, and there is the effect of hepatoprotective.
Claims (4)
1. a sobering preparation, is characterized in that: by following material, be prepared from lactose 400-800mg, starch 80-300mg, maltose 50-150mg, curcuma powder 50-100mg, curcumin 10-20mg, inositol 100-250mg, citric acid 30-70mg, nicotinic acid 10-40mg, vitamin C 50-150mg, vitamin E 4-8mg, vitamin B6 5-15mg, edible essence 30-70mg, correctives 50-250mg; And described correctives is sucrose.
2. sobering preparation according to claim 1, is characterized in that: in described sobering preparation,
Lactose is 800mg, and starch is 300mg, and maltose is 100mg, and curcuma powder is 100mg, and curcumin is 20mg, inositol is 250mg, and citric acid is 70mg, nicotinic acid 20mg, vitamin C 100mg, vitamin E 5mg, vitamin B6 10mg, edible essence 50mg, correctives 100mg; Or
Lactose is 600mg, and starch is 200mg, and maltose is 80mg, and curcuma powder is 80mg, and curcumin is 20mg, and inositol is 200mg, and citric acid is 60mg, nicotinic acid 15mg, vitamin C 80mg, vitamin E 4mg, vitamin B6 8mg, edible essence 40mg, correctives 80mg; Or
Lactose is 400mg, and starch is 100mg, and maltose is 60mg, and curcuma powder is 50mg, and curcumin is 15mg, and inositol is 180mg, and citric acid is 50mg, nicotinic acid 12mg, vitamin C 70mg, vitamin E 4mg, vitamin B6 6mg, edible essence 30mg, correctives 60mg.
3. a kind of sobering preparation according to claim 1, is characterized in that: described sobering preparation is used for making capsule, tablet, granule, oral liquid and beverage.
4. sobering preparation according to claim 1, is characterized in that: described sobering preparation adopts following processing step;
A) by starch 80-300mg, lactose 400-800mg adds purified water 1000-2000ml, stirs, and is heated to 100 ℃;
B) get curcumin 10-20mg, curcuma powder 50-100mg, correctives 50-250mg, vitamin C 50-150mg, vitamin E 4-8mg, inositol 100-250mg, citric acid 30-70mg, vitamin B6 5-15mg, nicotinic acid 10-40mg, edible essence 30-70mg, maltose 50-150mg, evenly mixes; Wherein, described curcumin is fermentation curcumin;
C) will in the mixture in step B, add the purified water of 1000-2000ml and evenly mix;
D) mixture in steps A is carried out cooling, the mixture obtaining after cooling evenly mixes with the mixture in step C;
E) mixture obtaining in step 4 is first divided and is filled to every bag of 200ml, then autoclaving, is finished product.
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| CN201210015234.4A CN102764408B (en) | 2012-01-18 | 2012-01-18 | Dealcoholic preparation |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103535742B (en) * | 2013-09-27 | 2016-01-27 | 应博 | Anti-alcohol liver protection composition |
| CN104012972A (en) * | 2014-06-17 | 2014-09-03 | 广东奇灵制药有限公司 | Health-care capsule containing curcumin composition, and preparing method thereof |
| CN104382009A (en) * | 2014-10-24 | 2015-03-04 | 青岛科技大学 | Health care tablets using VC and curcumin as components of main drugs |
| CN104306885A (en) * | 2014-10-24 | 2015-01-28 | 青岛科技大学 | Buccal tablets with main drug components of VE, VC and curcumin |
| CN104928120A (en) * | 2015-05-29 | 2015-09-23 | 尹治民 | Curcumin health care wine and preparation method thereof |
| CN113423407A (en) * | 2018-05-15 | 2021-09-21 | 青木勇 | Prophylactic and/or therapeutic agent for alcohol dependence or nicotine dependence |
| US20220280507A1 (en) * | 2019-08-02 | 2022-09-08 | Lianyungang Jinkang Hexin Pharmaceutical Co., Ltd. | Uses of 5-methyltetrahydrofolate and its composition |
| CN116114763B (en) * | 2023-01-12 | 2024-01-16 | 四川省食品发酵工业研究设计院有限公司 | Application of Pediococcus acidilactici brew R036 as anti-alcohol agent |
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| TW201117821A (en) * | 2009-09-24 | 2011-06-01 | House Foods Corp | Composition comprising curcuma longa extract together with curcuma zedoaria extract |
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