CN102755553A - 用于过敏性紫癜的紫银赤柏汤 - Google Patents
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Abstract
本发明涉及一种药物配方领域，具体地说是一种用于过敏性紫癜的紫银赤柏汤，其特征是，各原料药组成以重量百分比计为，紫草5～8％、金银花8～11％、赤芍7～9％、侧柏叶5～7％、牡丹皮5～7％、生地黄4～6％、荆芥4～6％、防风3～6％、玄参3～6％、麦冬5～7％、茜草3～5％、白茅根8～11％、丹参4～7％、甘草2～4％、三七粉2～4％、徐长卿6～9％、苦参4～7％，首先将三七粉单包，余16味原料药用水浸泡、煎熬，去渣得滤液后再加入三七粉，即制得紫银赤柏汤。本发明成本低，治疗过敏性紫癜疗效高，无毒副作用，具有解毒透疹、清热消斑、凉散风热、凉血止血等功效，适用于单纯型、关节型、腹型、肾型及混合型过敏性紫癜。
Description
技术领域
本发明涉及一种中成药制剂，具体地说是一种用于过敏性紫癜的紫银赤柏汤。
背景技术
众所周知，过敏性紫癜是一种超敏反应性毛细血管和细小血管炎，其特征为非血小板减少的皮肤紫癜，可伴有关节痛，腹痛和肾脏病变。其病因复杂，细菌、病毒、食物和药物等均可导致发病，恶性肿瘤和自身免疫性疾病亦可为可能病因。发病机制可能为III型超敏反应，抗原抗体结合形成的循环免疫复合物在血管壁沉积，激活补体，导致毛细血管和小血管壁及其周围产生炎症，使血管壁通透性增加，从而产生各种临床表现。临床多见于儿童和青少年，男性多于女性，好发于下肢，以小腿伸侧为主，重者可波及上肢、躯干。发病前患者有上呼吸道感染、低热、全身不适等前驱症状，继而出现针尖样至黄豆大的可触及的瘀点或瘀斑，部分有融合倾向，常分批出现，病程长短不一，可数日或1～2年，易复发。严重者可有便血，甚至出现肠套叠、穿孔。如并发肾脏损害称为肾型，少数可出现程度不等的肾功能损害。临床治疗寻找原因非常困难，主要是对症处理及给予糖皮质激素，对身体伤害很大。
发明内容
本发明所要解决的技术问题是为了克服现有技术的不足，提供一种用于过敏性紫癜的紫银赤柏汤，成本低，治疗过敏性紫癜疗效高，无毒副作用，具有解毒透疹、清热消斑、凉散风热、凉血止血等功效，适用于单纯型、关节型、腹型、肾型及混合型过敏性紫癜。
本发明解决上述技术问题采用的技术方案是：一种用于过敏性紫癜的紫银赤柏汤，其特征是，各原料药组成以重量百分比计为，紫草5～8％、金银花8～11％、赤芍7～9％、侧柏叶5～7％、牡丹皮5～7％、生地黄4～6％、荆芥4～6％、防风3～6％、玄参3～6％、麦冬5～7％、茜草3～5％、白茅根8～11％、丹参4～7％、甘草2～4％、三七粉2～4％、徐长卿6～9％、苦参4～7％，首先将三七粉单包，余16味原料药用水浸泡、煎熬，去渣得滤液后再加入三七粉，即制得紫银赤柏汤。
本发明的有益效果是，成本低，治疗过敏性紫癜疗效高，无毒副作用，具有解毒透疹、清热消斑、凉散风热、凉血止血等功效，适用于单纯型、关节型、腹型、肾型及混合型过敏性紫癜。
具体实施方式
下面结合实施例对本发明作进一步的描述：
实施例1：采用紫草、金银花、赤芍、侧柏叶、牡丹皮、生地黄、荆芥、防风、玄参、麦冬、茜草、白茅根、丹参、甘草、三七粉、徐长卿、苦参为原料制备而成。其组分(重量％)每副为紫草6.8、金银花9.8、赤芍8.5、侧柏叶5.3、牡丹皮6.4、生地黄5.9、荆芥5.7、防风5.3、玄参4.8、麦冬6.1、茜草4.1、白茅根9.2、丹参5.5、甘草2.4、三七粉2.2、徐长卿7.1、苦参4.9。取上述17味原料总重量150克，首先将三七粉单包，在室温下将上述余16味加水1000～1200ml，浸泡3～4小时，然后用武火煮沸文火煎熬至60分钟，去渣得滤液250ml，药渣再加水250～300ml煎熬30分钟左右，去渣得滤液50ml，共得300ml药汁，装入无菌玻璃瓶内，再倒入单包三七粉，混合均匀，即制得紫银赤柏汤，密封瓶盖备用。每日1剂，每天分2次口服，每次空腹服100ml，余100ml药汁每日分2次，用无菌棉签蘸取药汁涂擦患处，口服与患部皮肤涂擦药汁同步进行。7天为一疗程，休息3～5天，再进行下一疗程，一般应用3～5个疗程。
本发明主药紫草煎剂有缓和的解热作用，有明显的抑制小鼠动情周期和生育力的效果，并有明显的抗垂体***及抗绒毛膜***作用。对絮状表皮癣菌、羊毛状小芽孢癣菌等皮肤真菌均有抑制作用。性味甘、咸、寒，归心、肝经。具有凉血、活血、解毒透疹功效，用于血热、毒盛、斑疹紫黑、麻疹不透、疮疡、湿疹、水火烫伤。金银花抑菌试验对金黄色葡萄球菌、白色葡萄球菌及乙型溶血性链球菌等均有抑制作用，能与胆固醇结合，从而减少肠道对胆固醇的吸收，有促进白细胞吞噬等。性味甘、寒，归肺、心、胃经。具有清热解毒、凉散风热功效，用于痈肿疔疮、喉痹、丹毒、热毒血痢，风热感冒，温病发热。赤芍性味苦、微寒、归肝经。具有清热、凉血、散瘀止痛功效，用于温毒发斑，吐血衄血、目赤肿痛、肝郁胁痛、经闭痛经、癓瘕腹痛、跌扑损伤、痈肿疮疡。侧柏叶性味苦、涩、寒，归肺、肝、脾经。具有凉血止血，生发乌发功效，用于吐血衄血、咯血、便血、崩漏下血、血热脱发、须发早白。牡丹皮性味苦、辛、微寒，归心、肝、肾经。具有清热凉血、活血化瘀功效，用于温毒发斑、吐血衄血、夜热早凉、无汗骨蒸、经闭痛经、痈肿疮毒等。生地黄性味甘、寒，归心、肝、肾经。具有清热凉血、养阴、生津功效，用于热病、舌绛烦渴、阴虚内热、骨蒸劳热、内热消渴、吐血衄血、发斑发疹。荆芥性味辛、微温，归肺、肝经，具有解表散风，透疹功效，用于感冒、头痛、麻疹、风疹、疮疡初起。防风性味辛、甘、温，归膀胱、肝、脾经。具有解表祛风、胜湿、止痉功效，用于感冒头痛、风湿痹痛、风疹瘙痒、破伤风。玄参性味甘、苦、咸、微寒，归肺、胃、肾经。具有凉血滋阴、泻火解毒功效。用于热病伤阳、舌绛烦渴、温毒发斑、津伤便秘、骨蒸劳嗽、目赤咽痛、瘰疬、白喉等。麦冬性味甘、微苦、微寒，归心、肺、胃经。具有养阴生津、润肺清心功效，用于肺燥干咳、虚痨咳嗽、津伤口渴、心烦失眠、内热消渴、肠燥便秘、咽白喉。茜草性味苦、寒、归肝经。具有凉血、止血、祛瘀、通经功效，用于吐血、衄血、崩漏、外伤出血、经闭瘀阻、关节痹痛、跌扑肿痛。白茅根性味甘、寒，归肺、胃、膀胱经。具有凉血止血、清热利尿功效。用于血热吐血、衄血、尿血、热病烦渴、黄疸、水肿、热淋涩痛等。丹参性味苦、微寒，归心、肝经。具有祛瘀止痛、活血通经、清心除烦功效。用于***、经闭痛经、热痹疼痛、心烦不眠、癓瘕积聚、疮疡肿痛等。甘草性味甘、平，归心、肺、脾、胃经。具有补脾益气、清热解毒、祛痰止咳、缓急止痛、调和诸药功效。用于脾、胃虚弱、倦怠乏力、心悸气短、咳嗽痰多、缓解药物毒性、烈性等。三七粉性味甘、微苦、温，归肝、胃经。具有散瘀止血、消肿定痛功效，用于咯血、吐血、衄血、便血、崩漏、外伤出血等。徐长卿性味辛、温，归肝、胃经。具有祛风化湿、止痛止痒功效，用于风湿痹痛、胃痛胀满、荨麻疹、湿疹等。苦参性味苦、寒，归心、肝、胃、大肠、膀胱经。具有清热燥湿等功效，用于热痢、便血、阴肿阴痒、湿疹、湿疮、皮肤瘙痒、疥癣、麻风等。17味中草药巧妙组方，合理配伍，增加主药及功能相同或相近似药物疗效，减轻或消失毒副作用，促进皮疹及早消退，改善毛细血管脆性，提高机体免疫及抗炎作用。
本发明各原料还可按下表所列比例(重量百分比)混合的实施例来实现。其加工工艺与实施例1相同。
下面结合我院即山东省威海市文登中心医院进行的临床试验对本发明作进一步详细的描述：
1.病例选择：选择符合张学军主编的《皮肤性病学》“过敏性紫癜”第七版诊断标准。随机选取64例，男39例，女25例，年龄13-39岁，其中单纯型19例，关节型14例，腹型18例，肾型6例，混合型7例，疗程5-60天，平均39天。
2.治疗方法：每日1剂分2次口服，每次空腹服100ml，余100ml药汁每日分2次，用无菌棉签蘸取药汁涂擦患处，口服汤汁与患部皮肤涂擦药汁同步进行。7天为一疗程。休息3～5天，再进行下一疗程，应用3个疗程。
3.疗效评价标准：显效：口服及患部涂擦汤药3个疗程，患部皮肤黄豆大小可触及瘀点或瘀斑，或有融合倾向及分批出现的皮疹完全消退，再未复发；周身皮肤、消化道及肾型等临床症状体征完全消失；束臂试验、尿常规及大便隐血试验均正常。
有效：口服及患部涂擦汤药3个疗程，患部皮肤黄豆大小可触及瘀点或瘀斑，或有融合倾向及分批出现的皮疹基本消退，偶尔复发少量；周身皮肤、消化道及肾型等临床症状体征基本消失；束臂试验、尿常规及大便隐血试验偶尔出现轻微异常。
无效：口服及患部涂擦汤药3个疗程，患部皮肤、临床症状体征及试验、化验等均无改变。
4.治疗效果：使用本发明治疗64例，应用疗效评价标准进行治疗效果评价：显效39例，有效19例，无效7例，总有效率90.1％。
Claims (1)
1.一种用于过敏性紫癜的紫银赤柏汤，其特征是：各原料药组成以重量百分比计为，紫草5～8％、金银花8～11％、赤芍7～9％、侧柏叶5～7％、牡丹皮5～7％、生地黄4～6％、荆芥4～6％、防风3～6％、玄参3～6％、麦冬5～7％、茜草3～5％、白茅根8～11％、丹参4～7％、甘草2～4％、三七粉2～4％、徐长卿6～9％、苦参4～7％，首先将三七粉单包，余16味原料药用水浸泡、煎熬，去渣得滤液后再加入三七粉，即制得紫银赤柏汤。
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| CN102988805B (zh) * | 2012-11-22 | 2014-12-10 | 郭红玉 | 一种治疗过敏性紫癜的中药组合物 |
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