CN102755493B - External use drug for treating climacteric syndrome and preparation method thereof - Google Patents
External use drug for treating climacteric syndrome and preparation method thereof Download PDFInfo
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Abstract
The invention provides an external use drug for treating climacteric syndrome and further discloses a preparation method of the external use drug. The external use drug for treating the climacteric syndrome is good in therapeutic effect and convenient to take. The technical point is that the external use drug for the treating climacteric syndrome is composed, by weight, of 3%-6% of angelica sinensis, 1%-3% of ligusticum, 1%-3% of ligusticum wallichii, 3%-6% of Chinese yam, 1%-3% of veratrum album, 2%-5% of chasteberry, 3%-6% of soybean, 3%-7% of polyethylene glycol, 1%-3% of twain-80, 1%-3% of potassium hydroxide, 2%-4% of carbomer 2020,1%-3% of hydroxyethylcellulose, 10%-18% of ethanol,1%-3% of jiema bp and 30%-45% of deionized water. The external use drug belongs to the technical field of traditional Chinese medicine preparation.
Description
Technical field
The present invention discloses a kind of climacteric syndrome medicine for the treatment of, and specifically, is the external used medicine for the treatment of climacteric syndrome, belongs to Chinese drug preparation technique field.
Background technology
Climacteric syndrome is the series of symptoms being caused by decrease in estrogen.Minority women is because body can not adapt to very soon, and symptom is obvious, but does not generally need special treatment.Only a few serious symptom, the person that even affects live and work, needs to use the treatment of Chinese medicine kidney tonifying climacteric health.It is generally acknowledged, after women enters into the climacteric period, the variation of family and social environment all can increase the weight of its body & mind burden, makes climacteric syndrome be easy to occur or original existing some symptom is increased the weight of.The unsettled women of some mental status own, climacteric syndrome is just more obvious, even being happy and angry uncertainly.Although climacteric syndrome is due to due to property physiological change, sickness rate height has direct relation with personal story and psychological burden.Concerning psychology, than more sensitive climacteric women, physiological discomfort more easily causes psychological variation, so there are various menopause syndrome.Therefore, notice that mental adjustment is very important.
Climacteric syndrome (climacteric syndrome) means due to climacteric spirit psychology, neuroendocrine and metabolic alterations, the symptom of caused each tract and the comprehensive syndrome of body sheet.The aging of human longevity is the important development trend of modern society.Therefore climacteric and postmenopausal women's health care and diseases prevention and treatment, be the vital task that gynecologist and even entire society face.Climacteric syndrome also has title " menopausal syndrome " in Chinese medicine.How because women is by disconnected year of a warp, congenital kidney qi degradation, conception vessel is empty, and taichong channel declines, and menses will exhaust, and cause body negative and positive to be lost rare, or deficiency of kidney yin, and sun mistake is hidden; Or kidney yang deficiency, passages through which vital energy circulates loses the disease that occurs a series of function disorders in replenishing vital QI with drugs of warm nature.Disease is seen menoxenia, Blushing, and irritated irritability or melancholy, dizziness and tinnitus, xerostomia is just dry etc., is syndrome of deficiency of kidney yin; If disease is seen menoxenia, pallor Mental fatigue, aversion to cold and cold limbs, ache of the spinal column, pudendum heavily falls, and indigestion and loss of appetite loose stool is deficiency of kidney-YANG syndrome; If menoxenia, is doublely shown in flushed cheeks flushed complexion, fidgets due to deficiency is slept less, hectic fever night sweat, and soreness of the waist and knees, dizzy cardiopalmus, hypertension etc., be kidney deficiency in both YIN and YANG; In addition kidney two empty persons etc. intentionally still.
Common hypochondriacal performance: the clinical manifestation of involutional melancholia can be divided into two aspects: 1. physically differently show as that headache, giddy, cardiopalmus, chest pain, uncomfortable in chest, insomnia, hyperhidrosis, facial a burst of flushing, numb limbs and tense tendons, foot centre of the palm Tidal fever with perspiration, cold and heat double as, loss of appetite, gastrointestinal dysfunction, constipation, menoxenia and sexual hypofunction etc.Psychological problem Early manifestation for responsive, suspicious, irritated, irritability, fragility easily cry, depressed, absent minded etc.Along with the course of disease extends, the state of an illness increases the weight of gradually, occur being in a very depressed state, feel restless, rub hands stamp foot, in a constant state of anxiety, have a sense that A great misfortune has come.Trickle minor matter is too haggled over, too responsive to Self-variation, repeatedly recall offending thing in the past, and then occur from guilty idea, blame oneself and do not do one's duty, sorry relatives; Or regret deeply oneself and become disabled person, or think and oneself obtained " incurable disease ".It is very uncomfortable on body that patient often feels, very painful mentally, thinks that to live is no better than to die.In order to break away from misery, patient Chang Hui takes concealed manner to commit suiside by fair means or foul, is difficult to take precautions against.
The harm of disease: 1. hyposexuality: pubes and axillary trichomadesis, hyposexuality, vaginal secretions reduces, and occurs pain during sexual intercourse, has then caused the minimizing of sexual life number of times or has detested the generation of the emotion of sexual life.2. vegetative nerve function wadding is disorderly: have a dizzy spell, and xerostomia, there is burn feeling in throat, and thought is difficult for concentrating, and nervous exciting, and emotion is complicated and changeable, irascible temperament, insomnia key is forgotten, and skin is numb itches, and sometimes has formication.3. vascular dysfunctions: the hazard ratio of climacteric syndrome more typically shows as hectic fever, sometimes hot and sometimes cold, goes out profuse sweating, sometimes has dizziness, can occur several times or tens every day, and how at night-time attack, even occurs stuffy, the symptom such as breathe hard.4. osteoporosis: bone strength weakens, fracture susceptibility increases, bone metabolism negative balance, lose 50mg calcium average every day, often has lumbago and skelalgia, backache, height attenuating etc., slightly firmly i.e. fracture.5. menoxenia: this is one of harm of modal climacteric syndrome, often shows as menstrual blood volume and reduces gradually, and the cycle extends gradually, shorten menstrual period, so that menolipsis gradually.But sometimes also there will be hyper-menorrhea, and occur with situations such as a large amount of clots.6. obesity: generally surpassing normal type 15～20% be obesity, and climacteric is that the fat that the main period that women gets fat, especially abdominal part and buttocks etc. are located is the most easily piled up.
The disease that climacteric syndrome causes is such as 1, chronic pharyngolaryngitis, oral ulcer; 2, irritable bowel syndrome, colitis, chronic gastritis; 3, nervous headache, dizziness, giddy, insomnia, dreaminess; 4, depression, anxiety, fear, force, hypochondria; 5, hyperhidrosis, sweating due to debility, night sweat, fear of cold, aversion to wind; 6, heart neurosis, stomach neurosis; 7, neck muscle rigidity, joint migration pain, phantom pain; 8, poor memory, bradykinesia, neurasthenia; 9, easy catching a cold, hypoimmunity.
On market, use now as: external hormone pastes, the first, due to plaster be take package therapy skin ulceration and allergic phenomena of common occurrence; Two, hormone Replacement Therapy remains in many weak points at present, as increases the weight of liver load, increases the morbidity risk rate of carcinoma of endometrium, breast carcinoma, thrombotic disease, cholelithiasis etc., docks subject women and causes certain risk; Three, it is poor that rubber unguentum exists breathability, the stimulation to skin, easily irritated shortcoming; Four, the shortcoming such as the plaster of gel is not easy to control hardening time, and adhesion is poor, and mastic is excessive.
Summary of the invention
For the problems referred to above, the invention provides the external used medicine that a kind of therapeutic effect is good, climacteric syndrome is treated in medication easily.
For achieving the above object, last technical scheme of the present invention is such: a kind of external used medicine for the treatment of climacteric syndrome, is comprised of the raw material of following weight ratio: Radix Angelicae Sinensis 3%-6%, Rhizoma Chuanxiong 1%-3%, Fructus Citri Sarcodactylis 1%-3%, Rhizoma Dioscoreae 3%-6%, white hellebore 1%-3%, holy and pure certain kind of berries 2%-5%, Semen sojae atricolor 3%-6%, Polyethylene Glycol 3%-7%, tween 80 1%-3%, potassium hydroxide 1%-3%, card ripple 20202%-4%, hydroxyethyl-cellulose 1%-3%, ethanol 10%-18%, germall bp1%-3%, deionized water 30-45%.
Further, the external used medicine of above-mentioned treatment climacteric syndrome, is comprised of the raw material of following weight parts: Radix Angelicae Sinensis 4%-5%, Rhizoma Chuanxiong 2%, Fructus Citri Sarcodactylis 2%, Rhizoma Dioscoreae 4%-5%, white hellebore 2%, holy and pure certain kind of berries 3%-4%, Semen sojae atricolor 4%-5%, Polyethylene Glycol 4%-6%, tween 80 2%, potassium hydroxide 2%, card ripple 20203%, hydroxyethyl-cellulose 2%, ethanol 13%-15%, germall bp2%, deionized water 35-40%.
After of the present invention, a technical scheme is such: comprise the steps: successively 1) by taking raw material by following weight ratio: Radix Angelicae Sinensis 3%-6%, Rhizoma Chuanxiong 1%-3%, Fructus Citri Sarcodactylis 1%-3%, Rhizoma Dioscoreae 3%-6%, white hellebore 1%-3%, holy and pure certain kind of berries 2%-5%, Semen sojae atricolor 3%-6%, Polyethylene Glycol 3%-7%, tween 80 1%-3%, potassium hydroxide 1%-3%, card ripple 20202%-4%, hydroxyethyl-cellulose 1%-3%, ethanol 10%-18%, germall bp1%-3%, deionized water 30-45%; 2) Radix Angelicae Sinensis 3%-6% step 1) being taken, Rhizoma Chuanxiong, Fructus Citri Sarcodactylis, Rhizoma Dioscoreae, white hellebore, the holy and pure certain kind of berries, the broken coarse powder of making of Semen sojae atricolor is put in extractor, then adds dimethyl sulfoxide moistening, after adding water to add a cover 48 hours, carry out hot reflux extraction, adding activated carbon to adopt centrifuge to carry out solid-liquid separation decolouring the extracting solution extracting removes dimethyl sulfoxide, removes the starch of extracting solution the inside, pectin at membrane filtration; 3) adding Polyethylene Glycol, temperature-80, potassium hydroxide, card ripple 2020, hydroxyethyl-cellulose, ethanol, germall bp static 12 hours, high-speed stirred in high speed scissors blender then, the decolouring of centrifugalize at normal temperatures, obtains.
Further, the external used medicine preparation method of above-mentioned treatment climacteric syndrome, the methyl sulfoxide addition described in step 1) was for just soaking crude drug.
Further, the external used medicine preparation method of above-mentioned treatment climacteric syndrome, the heart separation described in step 3) is that the high-power Chinese medicine centrifuge that 105 types 2300 turn carries out solid-liquid separation decolouring.
Compared with prior art, the external used medicine for the treatment of climacteric syndrome provided by the invention, taked with compound non-woven fabrics soaking medicated liquid, only need when nursing, heat by needs the ventral groove portion that sticks, the integrated operation time only needs 20 minutes can reach curative effect, because of this product, taked advanced extraction and ultrafiltration technology and made the as clear as crystal fishy smell without Chinese medicine of traditional herb liquid color, can on skin, not dye, because done without thermal source PROCESS FOR TREATMENT, so reduce greatly the stimulation of Chinese medicine agent to skin, using non-woven fabrics to invade the method that bubble medicinal liquid heats simultaneously can enter fast subcutaneous by medicinal liquid under the effect of efficient transdermal agent, add the characteristic of using the natural plant two-ways regulation hormone of rational Chinese medicine, collocation can improve the permeability of Skin Cell, chafe body of gland opening increases, improve microcirculation and body hemodynamics and be easy to be penetrated absorption by medicine, disease is controlled.The untoward reaction of oral medicine and untoward reaction and the drawback of external use plaster product have been solved.
The specific embodiment
Below in conjunction with the specific embodiment, the present invention is described in further detail, but do not form any limitation of the invention, and the change of the limited number of time that anyone does within the scope of the claims in the present invention, still in claim protection domain of the present invention.
Embodiment 1
Treat an external used medicine for climacteric syndrome, by the raw material of following weight ratio, formed: Radix Angelicae Sinensis 3%, Rhizoma Chuanxiong 1%, Fructus Citri Sarcodactylis 3%, Rhizoma Dioscoreae 3%, white hellebore 1%, the holy and pure certain kind of berries 2%, Semen sojae atricolor 6%, Polyethylene Glycol 7%, tween 80 3%, potassium hydroxide 1%, card ripple 20204%, hydroxyethyl-cellulose 2%, ethanol 18%, germall bp1%, deionized water 45%.
Embodiment 2
Treat an external used medicine for climacteric syndrome, by the raw material of following weight ratio, formed: Radix Angelicae Sinensis 3%, Rhizoma Chuanxiong 1%, Fructus Citri Sarcodactylis 1%, Rhizoma Dioscoreae 6%, white hellebore 3%, the holy and pure certain kind of berries 5%, Semen sojae atricolor 4%, Polyethylene Glycol 3%, tween 80 1%, potassium hydroxide 1%, card ripple 20202%, hydroxyethyl-cellulose 3%, ethanol 10%%, germall bp3%, deionized water 55%.
Embodiment 3
Treat an external used medicine for climacteric syndrome, by the raw material of following weight ratio, formed: Radix Angelicae Sinensis 5%, Rhizoma Chuanxiong 2%, Fructus Citri Sarcodactylis 2%, Rhizoma Dioscoreae 4%, white hellebore 2%, the holy and pure certain kind of berries 4%, Semen sojae atricolor 5%, Polyethylene Glycol 5%, tween 80 2%, potassium hydroxide 2%, card ripple 20203%, hydroxyethyl-cellulose 2%, ethanol 12%, germall bp2%, deionized water 48%.
Implement to treat in 1 to 3 the preparation method of the external used medicine of climacteric syndrome, Chinese medicine pulverizing is made to coarse powder puts in extractor, putting into dimethyl sulphoxide solution adds solvent to cover Chinese medicine coarse powder after Chinese medicine coarse powder is moistening again, add a cover and within 48 hours, then carry out hot reflux extraction, extractor flow export place heating 1 minute antibacterial (because dimethyl sulfoxide boiling point is 189 ° of C) is killed various microorganisms in extracting solution and antibacterial moment, adding activated carbon to use the high-power Chinese medicine centrifuge that 105 types 2300 turn to carry out solid-liquid separation decolouring, after carry out 5000da membrane filtration by the starch in medical material, pectin, the macromolecular substances such as vegetable protein activated carbon filter this product aqueous solution adding Polyethylene Glycol, tween 80, potassium hydroxide, card ripple 2020, hydroxyethyl-cellulose, ethanol, static 12 hours of germall bp, then in high speed scissors blender, high-speed stirred 180 minutes (room temperature) obtains this product.
During use, with compound non-woven fabrics soaking medicated liquid, only need when needs are nursed, heat the ventral groove portion that sticks, the integrated operation time only needs 20 minutes can reach curative effect
Test example
300 climacteric syndrome patients have been carried out to medication experiment, and concrete curative effect can be divided following three grades: cure, climacteric syndrome phenomenon disappears; Take a turn for the better, climacteric syndrome phenomenon takes a turn for the better; Invalid, the same with original situation after medication, without any change.
Effect: medication two weeks healing person accounts for 76%, medication two weeks improvement person accounts for 93.6%; A medication healing in month accounts for 95%, and a month improvement person of medication accounts for 96%; Medication after three months healing person account for 100%.
Claims (5)
1. an external used medicine for the treatment of climacteric syndrome, is characterized in that, consists of: Radix Angelicae Sinensis 3%-6% the raw material of following weight ratio, Rhizoma Chuanxiong 1%-3%, Fructus Citri Sarcodactylis 1%-3%, Rhizoma Dioscoreae 3%-6%, white hellebore 1%-3%, holy and pure certain kind of berries 2%-5%, Semen sojae atricolor 3%-6%, Polyethylene Glycol 3%-7%, tween 80 1%-3%, potassium hydroxide 1%-3%, card ripple 20202%-4%, hydroxyethyl-cellulose 1%-3%, ethanol 10%-18%, germall bp1%-3%, deionized water 45-55%.
2. the external used medicine for the treatment of climacteric syndrome according to claim 1, is characterized in that, consists of: Radix Angelicae Sinensis 4%-5% the raw material of following weight ratio, Rhizoma Chuanxiong 2%, Fructus Citri Sarcodactylis 2%, Rhizoma Dioscoreae 4%-5%, white hellebore 2%, holy and pure certain kind of berries 3%-4%, Semen sojae atricolor 4%-5%, Polyethylene Glycol 4%-6%, tween 80 2%, potassium hydroxide 2%, card ripple 20203%, hydroxyethyl-cellulose 2%, ethanol 13%-15%, germall bp2%, deionized water 48-52%.
3. the external used medicine preparation method for the treatment of climacteric syndrome claimed in claim 1, is characterized in that, comprises the steps: successively 1) by weight ratio claimed in claim 1, take each raw material; 2) Radix Angelicae Sinensis 3%-6% step 1) being taken, Rhizoma Chuanxiong, Fructus Citri Sarcodactylis, Rhizoma Dioscoreae, white hellebore, the holy and pure certain kind of berries, the broken coarse powder of making of Semen sojae atricolor is put in extractor, then adds dimethyl sulfoxide moistening, after adding water to add a cover 48 hours, carry out hot reflux extraction, adding activated carbon to adopt centrifuge to carry out solid-liquid separation decolouring the extracting solution extracting removes dimethyl sulfoxide, removes the starch of extracting solution the inside, pectin at membrane filtration; 3) adding Polyethylene Glycol, temperature-80, potassium hydroxide, card ripple 2020, hydroxyethyl-cellulose, ethanol, germall bp static 12 hours, high-speed stirred in high speed scissors blender then, the decolouring of centrifugalize at normal temperatures, obtains.
4. according to the external used medicine preparation method of the treatment climacteric syndrome described in right 3, it is characterized in that step 2) described methyl sulfoxide addition was for just soaking crude drug.
5. according to the external used medicine preparation method of the treatment climacteric syndrome described in right 3, it is characterized in that, the heart separation described in step 3) is that the high-power Chinese medicine centrifuge that 105 types 2300 turn carries out solid-liquid separation decolouring.
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| CN1515251A (en) * | 2003-08-25 | 2004-07-28 | 莉 马 | Composition with function of beautifying face and its application |
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| CN1515251A (en) * | 2003-08-25 | 2004-07-28 | 莉 马 | Composition with function of beautifying face and its application |
Non-Patent Citations (2)
| Title |
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| 王光辉等.近10年来中医治疗更年期综合征研究进展.《中国中医基础医学杂志》.2006,第12卷(第10期),792-796. |
| 近10年来中医治疗更年期综合征研究进展;王光辉等;《中国中医基础医学杂志》;20061028;第12卷(第10期);792-796 * |
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