CN102727858B - Medical composition for treating headaches and migraine, preparation method and application thereof - Google Patents
Medical composition for treating headaches and migraine, preparation method and application thereof Download PDFInfo
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- CN102727858B CN102727858B CN2012102492020A CN201210249202A CN102727858B CN 102727858 B CN102727858 B CN 102727858B CN 2012102492020 A CN2012102492020 A CN 2012102492020A CN 201210249202 A CN201210249202 A CN 201210249202A CN 102727858 B CN102727858 B CN 102727858B
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Abstract
The invention provides a medical composition for treating headaches and migraine, which is prepared from the following raw drugs by weight: 20-40 parts of concha haliotidis, 20-40 parts of nacre, 20-40 parts of ossa draconis, 20-40 parts of concha ostreae, 12-24 parts of radix paeoniae alba, 8-16 parts of angelica sinensis, 8-16 parts of largehead atractylodes rhizome, 8-16 parts of radix bupleuri, 12-24 parts of tuckahoe, 20-30 parts of uncaria rhynchophylla, 8-16 parts of negundo chastetree fruit, 7-13 parts of chastetree fruit, 7-13 parts of mint, 7-13 parts of ginger and 4-8 parts of liquorice. The invention also provides a preparation method and application of the medical composition. The medical composition provided by the invention can be used for effectively eliminating or greatly relieving traditional Chinese medicine syndromes such as hyperaction of liver Yang, liver fire flaming, deficiency of liver-yin and kidney-yin, blood stasis and the like and symptoms of headaches and migraine caused by various diseases, and curing partial primary diseases of the headaches to a certain extent, therefore, a new approach is provided for the clinical medication.
Description
Technical field
The present invention relates to a kind of treatment headache, migrainous pharmaceutical composition and its production and use.
Background technology
Headache is one of common clinically symptom, typically refers to be confined to the head first half, comprises geisoma, helix upper limb and the outer knuckle line of the pillow pain with the upper part.Its concrete manifestation is often due to illness different because of the people, or superciliary ridge pain uneasiness, or the volume distending pain, or two temporo pain, or headache, or peck pain as chicken, or vexed pain is dizzy, or heaviness of the head as if it were tightly bandaged, or terrified, beat, or have the sense of the thing of subsides, worm to climb sense, or dizzy vexed muddle, or have a dull ache, or headache as split, or the like.Press clinical experience, headache can be divided into following a few class: migraine, tension-type headache, the half of headache of cluster headache and chronic paroxysmal, the headache of non-organic pathological changes, the headache that the head wound causes, the angiopathy headache, the headache that the vascular intracranial disease causes, the headache that the application of other article and machinery cause, non-cranium brain infects the headache that causes, the headache that metabolic disease causes, cranium, neck, eye, ear, nose, paranasal sinus, tooth, the oral cavity, headache that other structure illness of face or head cause or facial pain, the cranial nerve pain, nerve trunk afferent headache of pain and Cervicogenic Headache etc.Modern study finds that cause that the reason of headache is a lot, wherein some is serious fatal illness, but etiological diagnosis is often relatively more difficult.Not good enough or the other diseases of health states appears often being accompanied by in headache, and headache for a long time or frequent headache then may be the tendencys of severe disease.
At present, doctor trained in Western medicine there is no treatment headache, migrainous special-purpose specific medicament, must diagnosis cause that clearly what disease headache, migraine are, but just administration, cause that what disease headache, migraine are even sometimes diagnose out, also do not have active drug and give, can only use the general analgesic of somedon and so on.In addition, most Western medicine all have addiction and other toxic and side effects, can bring many-sided serious problems such as gastrointestinal tract as somedon, and it often do not have remarkable improvement to patient's headache, migraine.
And the traditional Chinese medical science focuses on determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, and behind the Chinese medicine reasonable compatibility, therefore little, the stable curative effect of its toxic and side effects, compares doctor trained in Western medicine in addition, and the traditional Chinese medical science has certain advantage when difficult diseases such as treatment headache, migraine., at present, the traditional Chinese medical science is divided into following a few class according to the pattern of syndrome of headache, migraine etc. with it: (1) headache that push up on the upper punch mountain peak with excessive rising of liver-YANG or flaming up of liver-fire; (2) hepatic and renal YIN deficiency, deficiency of YIN-blood and cause that venation is unsmooth and cause headache due to " stagnation of QI and blood may bring about pain "; (3) form the headache of brain arteries and veins inanition less because of cloudy anemia; (4) the blood stasis headache due to a variety of causes such as wound; Deng.
Summary of the invention
The object of the present invention is to provide a kind of drug effect good curing headache, migrainous pharmaceutical composition, and its production and use.
The invention provides a kind of treatment headache, migrainous pharmaceutical composition, it is the preparation that is prepared from by following materials of weight proportions medicine:
20 ~ 40 parts of Concha Haliotidis, 20 ~ 40 parts of Concha Margaritiferas, 20 ~ 40 parts of Os Draconis, 20 ~ 40 parts of Concha Ostreaes, 12 ~ 24 parts of the Radix Paeoniae Albas, 8 ~ 16 parts of Radix Angelicae Sinensis, 8 ~ 16 parts of the Rhizoma Atractylodis Macrocephalaes, 8 ~ 16 parts of Radix Bupleuri, 12 ~ 24 parts in Poria, 12 ~ 24 parts of Ramulus Uncariae Cum Uncis, 8 ~ 16 parts of Fructus Viticis Negundo, 7 ~ 13 parts of Fructus Viticises, 7 ~ 13 parts of Herba Menthaes, 7 ~ 13 parts in Rhizoma Zingiberis Recens, 4 ~ 8 parts in Radix Glycyrrhizae.
Further, it is the preparation that is prepared from by following materials of weight proportions medicine:
25 ~ 35 parts of Concha Haliotidis, 25 ~ 35 parts of Concha Margaritiferas, 25 ~ 35 parts of Os Draconis, 25 ~ 35 parts of Concha Ostreaes, 16 ~ 20 parts of the Radix Paeoniae Albas, 10 ~ 15 parts of Radix Angelicae Sinensis, 10 ~ 15 parts of the Rhizoma Atractylodis Macrocephalaes, 10 ~ 15 parts of Radix Bupleuri, 16 ~ 20 parts in Poria, 20 ~ 30 parts of Ramulus Uncariae Cum Uncis, 10 ~ 15 parts of Fructus Viticis Negundo, 8 ~ 12 parts of Fructus Viticises, 8 ~ 12 parts of Herba Menthaes, 8 ~ 12 parts in Rhizoma Zingiberis Recens, 4 ~ 8 parts in Radix Glycyrrhizae.
Further preferably, it is the preparation that is prepared from by following materials of weight proportions medicine:
30 parts of Concha Haliotidis, 30 parts of Concha Margaritiferas, 30 parts of Os Draconis, 30 parts of Concha Ostreaes, 18 parts of the Radix Paeoniae Albas, 12 parts of Radix Angelicae Sinensis, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts of Radix Bupleuri, 18 parts in Poria, 24 parts of Ramulus Uncariae Cum Uncis, 12 parts of Fructus Viticis Negundo, 10 parts of Fructus Viticises, 10 parts of Herba Menthaes, 10 parts in Rhizoma Zingiberis Recens, 6 parts in Radix Glycyrrhizae.
Wherein, described Os Draconis are Os Draconis, and described Concha Ostreae is a Concha Ostreae.
In the raw materials used medicine of the present invention, Os Draconis for ancient times mammal resemble the skeleton fossil of class, rhinoceros class, Hippocampal cortex, bovine, deer class etc.; Fructus Viticis Negundo is the fruit of Verenaceae Vitex plant five-leaved chaste tree; Other crude drug are referring to " 2010 editions first one of Chinese pharmacopoeia.
Wherein, it is to be active component by the water of the medical material powder of described crude drug or crude drug or extractive with organic solvent, adds the preparation that adjuvant pharmaceutically commonly used or complementary composition are prepared from.
Further, described preparation is oral formulations or ejection preparation.
Further, described oral formulations is granule, powder, pill, drop pill, capsule, soft capsule, tablet or oral liquid.
The present invention also provides the preparation method of aforementioned pharmaceutical compositions, and it comprises following operating procedure:
(1) by prescription weight proportion weighting raw materials;
(2) get Concha Haliotidis, Concha Margaritifera, Os Draconis, Concha Ostreae and be decocted first, add after the Radix Paeoniae Alba, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Radix Bupleuri, Poria, Fructus Viticis Negundo, Fructus Viticis, Rhizoma Zingiberis Recens, Radix Glycyrrhizae decoct again, the back is Herba Menthae and Ramulus Uncariae Cum Uncis down, collects decocting liquid; Medicinal residues decoct with water 2 times again, merge each time decocting liquid, after concentrating, add that pharmaceutically available adjuvant or complementary composition are prepared into conventional formulation.
The present invention also provides the purposes of aforementioned pharmaceutical compositions in the medicine of preparation treatment headache.
Further, described medicine is the treatment migraine, the headache of non-organic pathological changes, tension-type headache, cluster headache, the headache that the head wound causes, angiopathy headache, the headache that the vascular intracranial disease causes, the headache that the application of other article and machinery cause, non-cranium brain infects the headache that causes, the headache that metabolic disease causes, cranium, neck, eye, ear, nose, paranasal sinus, tooth, the oral cavity, the headache that other structure illness of face or head cause, the cranial nerve pain, the afferent headache of nerve trunk pain, Cervicogenic Headache, or the medicine of the half of headache of chronic paroxysmal.
Further, described medicine is treatment excessive rising of liver-YANG or flaming up of liver-fire and the headache on top, upper punch mountain peak; Or the hepatic and renal YIN deficiency, deficiency of YIN-blood and cause the unsmooth headache that causes of venation; Or because of cloudy anemia few due to headache; Or the headache due to the wound blood stasis.
Generally acknowledged that at present " organic conception ", " determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs ", " compound recipe use ", " the compound compatibility medication is as using military forces " are the most effective several big advantages of science of the traditional Chinese medical science, wherein " the compound compatibility medication is as using military forces " is the original theory of Chinese medicine of very science.Each medicine tight compatibility all linked with one another as arraying troops for battle in the traditional Chinese medical science prescription is its effective means that is better than the Western medicine prescription.The tcm prescription theory is thought, each prescription, not only need to select the suitable appropriate compatibility of medicine according to etiology and pathogenesis, the basic structure that also should meet prescription simultaneously, the i.e. prescription compatibility theory of " monarch, minister, help, make ", the prescription compatibility of so-called " monarch, minister, help, make " is exactly that it is based upon the scientific matching on the comprehensive judgement basis of disease pathogenesis.In medical square tube cross too many levels, many target spots and integrate the biological mechanism of regulating, disease or symptom to headache, the such cause of disease complexity of migraine, treatment difficulty are regulated and control, can obtain than better, the more persistent therapeutic effect of Western medicine, and this curative effect is to be based upon on the accurate instruction of the original theory of above-mentioned traditional Chinese medical science tradition, and prescription of the present invention is just being followed this principle.
In traditional Chinese medical science traditional theory, headache, migraine extensively relates to internal organs and meridians thereof such as liver, kidney, gallbladder, and the crown, two temporo (head partially) be the institute of channel course such as liver and gall especially.Excessive rising of liver-YANG or flaming up of liver-fire, the high sun of upper punch or the liver-fire that goes up inflammation can follow through on scurry the top, mountain peak, send out for have a headache, migraine.The hepatic and renal YIN deficiency, deficiency of YIN-blood, then cloudy anemia is few, and cloudy anemia is brain arteries and veins inanition at least, and brain arteries and veins inanition is then sent out headache, the migraine into " empty pain " property; The hepatic and renal YIN deficiency also can cause unsmooth, the hematogenous blockage of venation, and hematogenous blockage is venation block then, thereby sends out headache for " stagnation of QI and blood may bring about pain ", migraine (traditional Chinese medical science well-known saying has saying of " general rule not bitterly, pain is then obstructed ").A variety of causes such as wound can cause cranium brain blood stasis, and blood stasis is then obstructed, and " stagnation of QI and blood may bring about pain " is to be blood stasis headache, migraine.
Product with Concha Haliotidis, Concha Margaritifera, Os Draconis, Concha Ostreae four highly seasoned towns in the pharmaceutical composition of the present invention are monarch drug altogether, the liver-yang of subduing the hyperactivity of YANG upper punch, and the liver-fire of scurrying in the suppression at first solves main cause.The liver happiness is gentle, and Liver and kidney needs cloudy blood self-restraint, and the Radix Paeoniae Alba is easing the affected liver first product, and Radix Angelicae Sinensis is the hat that nourishes blood, so with the Radix Paeoniae Alba, Radix Angelicae Sinensis yin nourishing blood, nourishing yin for softening liver is demanded excessive rising of liver-YANG, this cause of flaming up of liver-fire, auxiliary principal agent plays a role from an aspect, is to be ministerial drug; Liver happiness bar reaches dredges freely, disperses logical dredging, in addition, liver-yang and liver-fire are except that subduing the hyperactivity of YANG, the heresy that leakage is scurried also need lead it to evacuate outward, and Radix Bupleuri is soothing the liver quality goods, and it is good that Herba Menthae is dredged an effect, so with Radix Bupleuri, Herba Menthae is soothing the liver, and evil after the evacuation rising, be that auxiliary principal agent plays a role from another aspect, be other one group of ministerial drug.Traditional Chinese medical science internal organs theory is thought " seeing the disease of liver; knowing the liver disease will be transmitted into the spleen, in the ban tonifying the spleen ", the trouble medication of promptly all Liver Channel, all should block the fraud of its " transmitting into the spleen " with the product of " tonifying the spleen ", could bring into play better treatment Liver Channel sufferer drug effect and unlikely again hurt he dirty (spleen), for this reason, select for use the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Zingiberis Recens to serve as " tonifying the spleen " task, can reach in liver by bar again, Rhizoma Zingiberis Recens also has dredging of Herba Menthae sample to send out effect, and assist a ruler in governing a country prodrug and play a greater role, be to be adjuvant drug; The Ramulus Uncariae Cum Uncis YANG hyperactivity suppressing is ended headache, and Fructus Viticis Negundo is specially controlled headache, and Fructus Viticis then is longer than and is ended two temporos (head partially) pain, relatively the front at disease this, this three flavor is the product that take stopgap measures for assisting a ruler in governing a country, so be another group adjuvant drug.Glycyrrhizin is apt to coordinating the actions of various ingredients in a prescription, often with for making, its property is slow in addition, can relax pain, thereby pharmaceutical composition of the present invention is also filled the post of messenger drug with Radix Glycyrrhizae, collaborative proving effective.
The caused headache of aforementioned multiple disease, cephalagra can effectively be eliminated or greatly alleviate to pharmaceutical composition of the present invention, can cure the part primary disease of headache to a certain extent, for clinical application provides a kind of new selection.
The specific embodiment
Embodiment 1 preparation of drug combination of the present invention
Get Concha Haliotidis 30g, Concha Margaritifera 30g, Os Draconis 30g, Concha Ostreae 30g, Radix Paeoniae Alba 18g, Radix Angelicae Sinensis 12g, Rhizoma Atractylodis Macrocephalae 12g, Radix Bupleuri 12g, Poria 18g, Ramulus Uncariae Cum Uncis 24g, Fructus Viticis Negundo 12g, Fructus Viticis 10g, Herba Menthae 10g, Rhizoma Zingiberis Recens 10g, Radix Glycyrrhizae 6g.Each flavour of a drug takes by weighing according to quantity, mix the water purification with capacity, intense fire be decocted first preceding Concha Haliotidis, Concha Margaritifera, Os Draconis, Concha Ostreae change slow fire and decoct more than 30 minutes again after boiling, surplus medicine except that Herba Menthae, Ramulus Uncariae Cum Uncis continues down, decocted again 10 minutes, and descended Herba Menthae and Ramulus Uncariae Cum Uncis at last again, continue to decoct 8 minutes to 10 minutes, after collecting decocting liquid, decoct with water again 2 times, merge each time decocting liquid, promptly get decoction.
Among the we, the consumption of Concha Haliotidis, Concha Margaritifera, Os Draconis, Concha Ostreae should be bigger, and Concha Haliotidis, two kinds of medicines of Concha Margaritifera all are Isodoses.Simultaneously, the stronger subduing the hyperactivity of YANG effect of product competence exertion of giving birth to of Os Draconis, Concha Ostreae, calcining product then has the astringent therapy effect, not only is unsuitable for the treatment of having a headache, and can increase the weight of the state of an illness on the contrary.Radix Paeoniae Alba consumption should not be too low, just can't bring into play " YANG hyperactivity suppressing " effect when hanging down consumption in this prescription.The Herba Menthae consumption is unsuitable too many, and the fraud of excessive diaphoresis is arranged too much.Rhizoma Zingiberis Recens is also unsuitable too many, the fraud of excessive diaphoresis is also arranged too much, and Rhizoma Zingiberis Recens can be worked in coordination with the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription on a small quantity.
Embodiment 2 preparation of drug combination of the present invention
Get the decoction of embodiment 1 preparation, after concentrating, granulate after adding proper starch, dextrin mixing.
Embodiment 3 preparation of drug combination of the present invention
Get Concha Haliotidis 40g, Concha Margaritifera 40g, Os Draconis 40g, Concha Ostreae 40g, Radix Paeoniae Alba 24g, Radix Angelicae Sinensis 12g, Rhizoma Atractylodis Macrocephalae 12g, Radix Bupleuri 12g, Poria 18g, Ramulus Uncariae Cum Uncis 30g, Fructus Viticis Negundo 16g, Fructus Viticis 13g, Herba Menthae 10g, Rhizoma Zingiberis Recens 10g, Radix Glycyrrhizae 8g.Each flavour of a drug takes by weighing according to quantity, mixes the water purification with capacity, intense fire be decocted first preceding Concha Haliotidis, Concha Margaritifera, Os Draconis, Concha Ostreae, change slow fire after boiling and decoct more than 30 minutes again, the surplus medicine except that Herba Menthae, Ramulus Uncariae Cum Uncis of continuing down decocted 10 minutes again, descend Herba Menthae and Ramulus Uncariae Cum Uncis at last again, continue to decoct 8 minutes to 10 minutes, behind the collection decocting liquid, decoct with water again 2 times, merge each time decocting liquid, after concentrating, dry, after adding an amount of dextrin, soluble starch granulation, tabletting promptly gets tablet.
Embodiment 4 preparation of drug combination of the present invention
Get Concha Haliotidis 35g, Concha Margaritifera 25g, Os Draconis 25g, Concha Ostreae 25g, Radix Paeoniae Alba 16g, Radix Angelicae Sinensis 10g, Rhizoma Atractylodis Macrocephalae 10g, Radix Bupleuri 10g, Poria 16g, Ramulus Uncariae Cum Uncis 22g, Fructus Viticis Negundo 10g, Fructus Viticis 8g, Herba Menthae 8g, Rhizoma Zingiberis Recens 8g, Radix Glycyrrhizae 4g.Each flavour of a drug takes by weighing according to quantity, mixes the water purification with capacity, intense fire be decocted first preceding Concha Haliotidis, Concha Margaritifera, Os Draconis, Concha Ostreae, change slow fire after boiling and decoct more than 30 minutes again, the surplus medicine except that Herba Menthae, Ramulus Uncariae Cum Uncis of continuing down decocted 10 minutes again, descend Herba Menthae and Ramulus Uncariae Cum Uncis at last again, continue to decoct 8 minutes to 10 minutes, merging filtrate concentrates, after the drying, add an amount of microcrystalline Cellulose, behind the mixing, encapsulated, promptly get capsule.
Below specify beneficial effect of the present invention by testing example.
Clinical (outpatient service) treatment situation of test example 1 pharmaceutical composition of the present invention
(1) accepts patient's situation for medical treatment
Patient's sex and the range of age: contain men and women, old and young, possess one of following symptom feature or more than, accept 269 examples altogether for medical treatment.
Symptom feature: or headache, or two temporo pain, or half of head (or temporo) is bitterly, or the temple pain, or supraorbital bone pain, or metopodynia, or pain behind the ear, or the back headache.Types of pain or distending pain, or peck pain, or empty pain, or vexed pain is dizzy, or nose heave pain, or have a dull ache, or headache as split as chicken, or terrified, beat, or have the sense of the thing of subsides, worm to climb sense, or dizzy vexed muddle etc.
Doctor trained in Western medicine medical diagnosis on disease: after the patient checked, determine to suffer from respectively among the above-mentioned 269 routine patients the half of headache of chronic paroxysmal, the headache of non-organic pathological changes, tension-type headache, cluster headache, the headache treated and that behind western medical treatment, still occur of head wound, the angiopathy headache, the headache that the vascular intracranial disease causes, the headache that other article and machinery cause, non-cranium brain infects the headache that causes, the headache that metabolic disease causes, cranium, neck, eye, ear, nose, paranasal sinus, tooth, the oral cavity, the headache that other structure illness of face or head cause, the cranial nerve pain, nerve trunk afferent headache of pain and Cervicogenic Headache, the headache of unknown cause, migraine or the like (also can referring to the headache International Classification ICHD-II).
With the theory of Chinese medical science differentiation of symptoms and signs for classification of syndrome, then above-mentioned patient belongs to excessive rising of liver-YANG or flaming up of liver-fire and top, upper punch mountain peak, or the hepatic and renal YIN deficiency, deficiency of YIN-blood and cause that venation is unsmooth to cause " stagnation of QI and blood may bring about pain ", or because of cloudy anemia forms headache, the migraine of brain arteries and veins inanition less, or the blood stasis headache pattern of syndrome such as (still being " stagnation of QI and blood may bring about pain ") due to a variety of causes such as wound.Wherein, with excessive rising of liver-YANG or flaming up of liver-fire and " yang-excess type " (the accounting for 55%) in the majority on top, upper punch mountain peak, secondly be " the few type of cloudy anemia " (the accounting for 30%) of the hepatic and renal YIN deficiency, deficiency of YIN-blood.
(2) treatment standard
Recovery from illness: the complete obiteration of above-mentioned symptom characteristics, check does not see that index of correlation is unusual.
Evident in efficacy: above-mentioned symptom obviously alleviates, and test rating has certain degree to improve simultaneously.
Curative effect is obvious: the above-mentioned one (patient's symptom and test rating) of getting.
Certain effect is arranged: patient's symptom alleviates to some extent, or index has improvement slightly.
Invalid: symptom remains unchanged, and index not to be improved.
(3) Therapeutic Method
1, embodiment 1 made decoction is a daily dose, take advantage of at every turn and take 200 to 400ml(8 years old following child time dosing of cutting down according to the circumstance when warm, but need to increase a day clothes number of times), 3 times on the one, take according to quantity on time, continue again to take after serveing on 7 with regard to drug withdrawal and having a rest 1, if also temporarily withdraw when having than heavy cold or other new trouble diseases.
2, notice that also science conditioning daily life (as not drinking, smoking, is not eaten or eaten less the food of pungent frying, delicious food savoury etc. " getting angry, it is hot to give birth to " " supporing yang rising ", eat fresh, light and more nutritious food more; Keep one's hair on, get angry, the self-closing cloudy gas or depressed of irritating, keep pleasant with happy; Greening, beautified habitat environment, and made its health clean and tidy, door and window ventilates, and the maintenance room air is fresh but can not room temperature too high or too low; Have a rest and movable appropriateness, and more regular.Or the like).
(4) therapeutic outcome
With embodiment 1 medicine composite for curing primary disease, men and women, old and young patient's 269 examples (in the majority with person in middle and old age) have obtained good curative effect.Treatment time, difference according to the difference of concrete conditions such as each conditions of patients weight, age size, physical strength and to some extent generally about 1 week～March, and is many about January to February.By above-mentioned treatment standard, among the 269 routine patients, 101 example recoveries from illness are arranged, cure rate reaches 37.5%; 112 routine effects are remarkable, reach 41.6%; 16 routine effects are obvious, account for 5.9%; 13 examples have certain effect, account for 4.8%; 27 routine DeGrains (invalid) account for 10.2%.Total effective rate reaches 89.8%.
Model case
The patient, the woman, 21 years old, unmarried, the doctor trained in Western medicine polytechnical student, patient right side migraine is about February, continuous more than, pain increases the weight of unbearably sometimes, when unhappy, when angry, when day hot, when tired, when edible frying savoury food or pick-me-up and before and after the menstruation for very.Irritated irritability, the time sense uncomfortable in chest rising, the time send out flushed face with red ears, thirst and drinking, clear when yellow during urine, even short red, stool is dry once in a while, and menstrual period, normal substantially (in advance but do not exceed a week) was on the low side through measuring, the piece silk is arranged during deep red menses, leucorrhea is normal substantially, fulminant leucorrhagia with yellowish discharge once in a while, wiry and frequent pulse, the tip of the tongue limit is red, yellow and thin fur.Doctor trained in Western medicine is not found the cause of disease, examines to be " migraine due to the unknown cause ", only gives oryzanol and so on conditioning, and symptom does not have and subtracts, and has a strong impact on patient's school work.
After move on to Chinese traditional treatment, the traditional Chinese medical science thinks that this patient belongs to excessive rising of liver-YANG or flaming up of liver-fire and headache due to the top, upper punch mountain peak, takes the embodiment of the invention 1 pharmaceutical composition, every day 3 times, only obeys 1 Zhou Eryu.Follow up a case by regular visits to and do not see recurrence.
In sum, the caused headache of aforementioned multiple disease, cephalagra can effectively be eliminated or greatly alleviate to pharmaceutical composition of the present invention, can cure the part primary disease of headache to a certain extent, for clinical application provides a kind of new selection.
Claims (1)
1. pharmaceutical composition for the treatment of headache, it is characterized in that: it is the preparation that is prepared from by following materials of weight proportions medicine:
20 ~ 40 parts of Concha Haliotidis, 20 ~ 40 parts of Concha Margaritiferas, 20 ~ 40 parts of Os Draconis, 20 ~ 40 parts of Concha Ostreaes, 12 ~ 24 parts of the Radix Paeoniae Albas, 8 ~ 16 parts of Radix Angelicae Sinensis, 8 ~ 16 parts of the Rhizoma Atractylodis Macrocephalaes, 8 ~ 16 parts of Radix Bupleuri, 12 ~ 24 parts in Poria, 20 ~ 30 parts of Ramulus Uncariae Cum Uncis, 8 ~ 16 parts of Fructus Viticis Negundo, 7 ~ 13 parts of Fructus Viticises, 7 ~ 13 parts of Herba Menthaes, 7 ~ 13 parts in Rhizoma Zingiberis Recens, 4 ~ 8 parts in Radix Glycyrrhizae.
2, pharmaceutical composition according to claim 1 is characterized in that: it is the preparation that is prepared from by following materials of weight proportions medicine:
25 ~ 35 parts of Concha Haliotidis, 25 ~ 35 parts of Concha Margaritiferas, 25 ~ 35 parts of Os Draconis, 25 ~ 35 parts of Concha Ostreaes, 16 ~ 20 parts of the Radix Paeoniae Albas, 10 ~ 15 parts of Radix Angelicae Sinensis, 10 ~ 15 parts of the Rhizoma Atractylodis Macrocephalaes, 10 ~ 15 parts of Radix Bupleuri, 16 ~ 20 parts in Poria, 22 ~ 26 parts of Ramulus Uncariae Cum Uncis, 10 ~ 15 parts of Fructus Viticis Negundo, 8 ~ 12 parts of Fructus Viticises, 8 ~ 12 parts of Herba Menthaes, 8 ~ 12 parts in Rhizoma Zingiberis Recens, 4 ~ 8 parts in Radix Glycyrrhizae.
3, pharmaceutical composition according to claim 2 is characterized in that: it is the preparation that is prepared from by following materials of weight proportions medicine:
30 parts of Concha Haliotidis, 30 parts of Concha Margaritiferas, 30 parts of Os Draconis, 30 parts of Concha Ostreaes, 18 parts of the Radix Paeoniae Albas, 12 parts of Radix Angelicae Sinensis, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts of Radix Bupleuri, 18 parts in Poria, 24 parts of Ramulus Uncariae Cum Uncis, 12 parts of Fructus Viticis Negundo, 10 parts of Fructus Viticises, 10 parts of Herba Menthaes, 10 parts in Rhizoma Zingiberis Recens, 6 parts in Radix Glycyrrhizae.
4, according to any described pharmaceutical composition of claim 1～3, it is characterized in that: described Os Draconis are Os Draconis, and described Concha Ostreae is a Concha Ostreae.
5, pharmaceutical composition according to claim 4 is characterized in that: described preparation is an oral formulations.
6, pharmaceutical composition according to claim 5 is characterized in that: described oral formulations is granule, powder, pill, capsule, tablet or oral liquid.
7, pharmaceutical composition according to claim 5 is characterized in that: described oral formulations is drop pill or soft capsule.
8, any described preparation of drug combination method of claim 1～3, it is characterized in that: it comprises following operating procedure:
(1) by prescription weight proportion weighting raw materials;
(2) get Concha Haliotidis, Concha Margaritifera, Os Draconis, Concha Ostreae and be decocted first, add after the Radix Paeoniae Alba, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Radix Bupleuri, Poria, Fructus Viticis Negundo, Fructus Viticis, Rhizoma Zingiberis Recens, Radix Glycyrrhizae decoct again, the back is Herba Menthae and Ramulus Uncariae Cum Uncis down, collects decocting liquid; Medicinal residues decoct with water 2 times again, merge each time decocting liquid, after concentrating, add that pharmaceutically available adjuvant or complementary composition are prepared into conventional formulation.
9, the purposes of any described pharmaceutical composition of claim 1～7 in the medicine of preparation treatment headache.
10, according to the described purposes of claim 9, it is characterized in that: described medicine is the treatment migraine, the headache of non-organic pathological changes, tension-type headache, cluster headache, the headache that the head wound causes, the angiopathy headache, non-cranium brain infects the headache that causes, the headache that metabolic disease causes, the cranial nerve pain, the medicine of nerve trunk afferent headache of pain or Cervicogenic Headache.
11, according to the described purposes of claim 9, it is characterized in that: described medicine is treatment excessive rising of liver-YANG or flaming up of liver-fire and the headache on top, upper punch mountain peak; Or the hepatic and renal YIN deficiency, deficiency of YIN-blood and cause the unsmooth headache that causes of venation; Or because of cloudy anemia few due to headache; Or the headache due to the wound blood stasis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102492020A CN102727858B (en) | 2012-07-18 | 2012-07-18 | Medical composition for treating headaches and migraine, preparation method and application thereof |
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| MY172207A (en) | 2012-12-21 | 2019-11-15 | Tasly Pharmaceutical Group Co | Pharmaceutical composition for treating headache, and preparation method thereof |
| CN103211998B (en) * | 2013-03-18 | 2014-08-20 | 赵霞 | Traditional Chinese medicine composition for treatment of yin deficiency and yang excess |
| CN103599325B (en) * | 2013-11-19 | 2016-03-16 | 太和县中医院 | One treats migrainous Chinese medicine |
| CN105363016A (en) * | 2015-12-28 | 2016-03-02 | 杨玲林 | Medicine for treating headache |
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| CN1260201A (en) * | 1999-09-10 | 2000-07-19 | 张发平 | Chinese preparatory medicine and its preparation method |
| CN101129864A (en) * | 2007-09-13 | 2008-02-27 | 尹克华 | Traditional Chinese medicine for treating tension headache |
| CN101385846A (en) * | 2007-09-14 | 2009-03-18 | 曾雄辉 | Preparation method of Jiawei Xiaoyao power preparation |
| CN102205033A (en) * | 2011-05-03 | 2011-10-05 | 王爱芹 | Preparation method of traditional Chinese medicine for treating headache-type influenza in children |
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| CN1260201A (en) * | 1999-09-10 | 2000-07-19 | 张发平 | Chinese preparatory medicine and its preparation method |
| CN101129864A (en) * | 2007-09-13 | 2008-02-27 | 尹克华 | Traditional Chinese medicine for treating tension headache |
| CN101385846A (en) * | 2007-09-14 | 2009-03-18 | 曾雄辉 | Preparation method of Jiawei Xiaoyao power preparation |
| CN102205033A (en) * | 2011-05-03 | 2011-10-05 | 王爱芹 | Preparation method of traditional Chinese medicine for treating headache-type influenza in children |
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